Blender wont find python in usr/local/bin
On OSX, open a terminal session.
In your user directory (e.g. mac/users/doeke) make sure you have a file named .bash_profile If it is not there then create one.

Open terminal.

sudo nano .bash_profile

add:

export PYTHONHOME=/usr/local/bin/python_whatever_the_fing_path_is

press ctrl + x to quit and hit y to save the file.

Now log in and out or reboot. Hopefully it is fixed now.