Is it possible to disable the mouse wheel?
It should be doable by removing (or changing) the Key Bindings in Blender. Go to File -> User Preferences -> Input and look for any Key Binding which is connected to the Wheel of the mouse. Like this:



In the example I'm deleting the binding for the Zoom in 3D View only. So in 2D Editors, you could still use it if you like. Otherwise, you'd need to remove it section by section.

To get it back, use the Restore button that shows up after you change or delete a binding (it will stay there as long as your keymap is different to the Defaults). If you want to keep your Blender Prefs this way, click Save User Settings