2D animating a simple image with simple movement
For a simple animation, start with the object in it's &quot;starting position&quot; with the timeline at 0. Press N to bring up the transform tools window, and press I over both the location and scale boxes to insert a keyframe (one press of I works for all three axis boxes).

Then, move your timeline forward, move and scale the object accordingly, and then again, press I over the rotation and scale, to set a new keyframe at the new time position with the new transforms applied. You should now be able to play your animation and watch the object move and scale accordingly.