Installing blender on another drive other than C:
The anwser is YES you can! You can install any software on any of the drive you have. I have my 2nd harddisk on partition. So that means I have my physical harddisk virtually cut up into 3 portion. I have D:,E: and X:. I install all my program on X: and save all my data on E: , as my C: is an SSD with only 120GB of disk space.

As it happens Blender is no exception. In fact blender comes in Zip format flavor which does not even require any conventional installation at all.

Note Change your title to "Installing blender on another drive other than C:" at least it makes the question not sound like an OS one :) cheers.