Python Script To Rename Bones In Armature
This will replace &quot;Skel123:&quot;, etc. with just &quot;Skel:&quot; in the names of bones (edit: and their armature, and their armature's object). Select the armature you want to do it to and make sure you are in Object mode before running it.
import bpy, re
ob = bpy.context.active_object
assert ob.type == &quot;ARMATURE&quot;
assert bpy.context.mode == 'OBJECT'
for thing in [ob, ob.data, *ob.data.bones]:
    thing.name = re.sub(r'Skel[0-9]+:', 'Skel:', thing.name)

If you want to remove all numbers instead of just the ones from the &quot;Skel:&quot; part, you can use re.sub(r'[0-9]', '', thing.name) instead.