Many shortcuts don't work in Blender 2.8. Are these bugs?
CRTL(or CMD) + ALT + 0 shortcut does not work


Edit > Preferences window > Input tab : check Emulate Numpad


  Many shortcuts don't work in Blender 2.8. Are these bugs?


Not bugs.You can find the new shortcuts in,

Edit > Preferences window > Keymap

Annoying at first but I get used to it quickly. 

Blender 2.8 is a big change and more "industry" compliant, for example:


left click for selection (instead of right click) 
Space bar for Play/pause
F3 for search, etc