Upgrading to 2.81 - How To Keep Settings and Addons
When you install 2.81, there is an option to import settings from 2.80. However it is unknown what custom tweaks you did to 2.80, so hard to answer if all will be that easy to transfer.

Under &lt;user&gt;/AppData/Roaming/Blender Foundation/Blender you'll find config files for all the version.

You won't loose addons, you will just have to copy them from 2.80 addon folder into 2.81 addon folder. Most addons will be fine, but some addons might not work under 2.81 and you'll have to wait until the addon developer updates the addon for 2.81. There are some small python API changes between 2.80 and 2.81.