Blender Video Editor: How to move a picture or movie from place a to place b and capture the movement into the video?
Yes, keyframes will allow you can automate your goal.

Select regular strip.
Add a Menu/Effect Strip/Transform strip to a regular video/image strip.
Select new transform strip.

Keyframe the position.  Frame 1.



In the image above the mouse was used the to get the [Insert Keyframe] menu option.

Next a second keyframe on frame 100.  Yellow indicates key frame.



Next Blender places the images on frames 2-99 via interpolation.



There are tutorial resources here a blender.stackexchange and other video websites.