Tips for making the face topology
QUICK TIP: The proper edge flow of your mesh is the key to a good looking model. Your topology is bad- it doesn't define the head's shape well. 
Start from extruding the eyelid circular shape, then do the same with lips. Keep going further and then connect eyelid and lips meshes together. And remember to avoid ngons (you've got some there).


I hope you get the idea. Of course it's one of the topology variant. Type 'manga head topology' in google graphics to see some different topology edge flows examples.