Unresponsive black screen; does not close
Open a new instance of Blender without opening any file, go to File > Open search for your file but before you open it untick the Load UI box at the bottom left of the File Browser editor.

Then open your Blend file, see if that works.

After successfully opening it Save As with a different file name.

You should probably submit your original corrupt blender file as a bug report in the bugtracker with a complete description like the one provided in your question, because it sounds like an issue that can produce corrupt .blend files that fail to open causing potential data loss.

In the future if you want to prevent this from happening you can make Blender never load the UI from other files bu unticking the Load UI option in File > User preferences > File > Save &amp; Load > Load UI