Creating 2D animations using 3D characters
Depends what you're good at. Of course Blender produces 2D images, and people have often done what you describe, so it's possible. 
Freestyle helps you outline objects if you want to go for the hand-drawn feel and there are tons of toon shaders out there for drawing like colors.
You can also use grease pencil in Blender (it was vastly improved in 2.80) if you'd rather stick to pure 2D.