Grease Pencil limitations
This style is totally possible with a combination of 3d,freestyle render and grease pencil.
The whole process can be done within Blender itself...including the compositing.

Here is a link to "Hero" a Blender and Grease pencil film to give you an idea of some of the possibilities.
https://www.youtube.com/watch?v=pKmSdY56VtY

But really...the sky is the limit.