Visible seams on tangent normal maps
Substance offers two options for normal maps, DirectX and OpenGl. DirectX is the default (normally set when you first setup a project). The difference between the two is that the green channel is inverted from one to the other. Blender expects normal maps in the OpenGl format. 

There should be options in Substance Painter to export with the OpenGl format instead.

You may need to look at export presets to do this:
https://support.allegorithmic.com/documentation/display/SPDOC/Creating+export+presets