NDOF Invert Blender 2.8
Blender now responds to changes made in the 3DConnexion properties application (this wasn't previously the case in 2.79). 
If you reverse all the navigation properties in the 3DConnexion advanced settings, the space mouse will respond as if it was set up with default settings in Blender. In every other CAD program I have used the opposite is true.

I can't seem to find any documentation of these changes or why it is mapped wrong by default.