Which is the better Topology? Left or Right? - [With Image Reference]
It entirely depends on what you're making. Edge-flow is a well-studied science all its own, so there are some good articles out there about how to make those decisions, like this one.

That being said, you ask if it's good practice to keep all the polys the same size. That also entirely depends on what you're doing. It can make certain things easier, like UV mapping (especially if you have to unwrap manually), and animated meshes will deform better (more predictably) if all the polys are the same size, but the renderer shouldn't care.

The most important thing you need to do here is merge the center line into one line. Other than that, we need more info about what problems you're facing and what you're trying to accomplish.