Noise in reflections on non-focused objects (cycles)
Multiuple Importance for Environment

I do not know how the pro-lighting skies addon works, but enabling Properties Panel / World / Settings / Multiple Importance and highly increasing the Map Resolution might reduce those noises, assuming the highlights are coming from the sky.

Composited Depth of Field

Instead of the real DOF you might try uing the Filter / Defocus node in the compositor.