Prevent fluid to flow through the walls of an obstacle
First of all, you should make sure that the basics of the fluid sim are set up correctly.


The domain should not be larger than necessary. The larger the domain, the more resolution you need for equal quality. You are just wasting baking time.
Scale should be applied (Ctrl+A) to the domain and the obstacle. Otherwise the results are somewhat unpredictable. This is usually the first step in troubleshooting a fluid sim.
There is no point in having a preview resolution of 100. You will always want to look at the final version, not the preview one, so to bake it at a high resolution is just more wasted baking time. Some people like to set the preview resolution to 1 because of this. But if you want to look at your animation before rendering to check the timing of camera movements, or whatever, something like the default 45 will do the job.
There is never ever a need for 4 subdivisions in the fluid boundary settings. At high resolutions (maybe about 300+) or if you want fluid particles, it should be set at 2, otherwise zero. You are just increasing the baking time without getting anything in return.


Now, if you have done all that, there is one more simple thing to do to prevent leakage. In the fluid boundary settings, uncheck Remove air bubbles. With this setting checked (which is the default), the fluid sim will basically avoid to have any space between the fluid and an obstacle, thus preferring to pass through. With high enough resolution this setting does not matter, but at low resolutions, very much so.

I hope that helped.