Smoke wont update when moving the source or resizing the domain?
There's a known bug with current Blender versions when using a Replay Cache (in the Domain settings, the Cache -&gt; Type -&gt; Replay setting).  See issues 77170 and 76095.
As a quick fix, you can go into the domain settings, and change just about anything (e.g., temporarily change the resolution divisions).  That'll invalidate and regenerate the cache, and your smoke should start generating from the new cube position.
You could also consider switching the cache from Replay to Modular, which gives you Bake and Free buttons to allow more direct control over the cache.