Change Screen Colors
Yes it can.
Enter the blender user preferencesCtrl-Alt-U Add go into the themes tab.
In side the themes tab you can customize all the colors.

When You are done, be sure to hit Save User Settings.

You can also Down Load Themes:

You can download themes for site such as blendswap, or by searching on the internet.
To install a theme, press install theme, and then open your theme, which should be a .xml file.

Then save your settings.