Printing a PDF for proper book binding
Browse your local bookstore and have a look at the most popular formats for hardcover books, mass market and trade paperbacks before you decide (if you are looking to publish and sell your book).
When it comes to copies for your own use, pick the format that is most comfortable to your eye / reading style (and your wallet, of course, some formats are more expensive to produce).
Most decent desktop publishing software have a selection of standard/ popular layouts for book and booklet printing you can use, even MS Publisher has some that are not too bad.