Using helium to make home brewed beer
To correct one point in the question, helium has the lowest water solubility of all gases. At one atmosphere and $\mathrm{25^oC}$, $\ce{CO2}$ is 100 times more soluble than $\ce{He}$ and $\ce{N2}$ is about twice as soluble as $\ce{He}$.  This is why deep-divers prefer helium to nitrogen.

At 45 psi, which is 3.1 atmospheres pressure, you could dissolve about 0.005 g $\ce{He}$ or roughly 30 mL when fully degassed.  A typical adult breath is around 500 mL, and of course the $\ce{He}$ will not degas instantly.  

The bottom line is that pressurizing beer with helium will not make you talk like Donald Duck.  And the biggest difference you would see between $\ce{N2}$ and $\ce{He}$ would be in your bank statement.