flory ( or theta) temperature
I'm going to use Theta-Solvent and Theta-temperature since that is what Wikipedia uses, and Wikipedia usually has the preferred names. 

In order to get a polymer to the Theta-Condition two factors must be considered.

(1) Solvent

A Theta-Solvent is a poor solvent for a polymer is one such that the interactions between the polymer segments and the solvent are minimized. This results in polymer segment interactions to be maximized. 

A good solvent for a polymer is one such that the interactions between the polymer segments and the solvent are maximized. This results in polymer segment interactions being minimized.

(2) Temperature

The Theta-temperature is the temperature for the particular theta-solvent 
which minimizes interactions between the polymer segments and the solvent.

Point

The combination of using a theta-solvent and being at the theta-temperature satisfies the theta-condition.

This makes experimental determination of important quantities such as the root mean square end-to-end distance or the radius of gyration much simpler.

Note

This assumes that polymer will self-coil into its lowest energy configuration. For polymers with same unit repeating this is not unlikely.

For proteins in biological systems this self-arrangement is unlikely. Proteins do not have a "repeating unit." Therefore biological systems have a mechanism to fold a protein in a certain way.