Does Amoxicillin (as trihydrate) degrade in stomach acid?
Because amoxicillin is available as oral tablets, it can be ascertained that it is not significantly degraded to a useless form in the stomach.  In fact, it has an oral bioavailability of 95% (meaning 95% of the orally ingested material goes into the blood stream rather than being destroyed in the stomach). The term for an oral medication being destroyed before it enters the blood stream is "first pass metabolism". So oral amoxicillin can be said to undergo minimal first pass metabolism. Oral potassium clavulanate also has a high oral bioavailability.