Why do unripe papayas taste less bitter after being boiled?
Unripe papaya contains a high concentration of Papain enzyme, which is an enzyme that breaks down peptide bonds and therefore "digests" proteins, including potentially human tissues.  Enzymes themselves are proteins, and proteins tend to have a bitter taste.

Papain can self digest into amino acids over time, and this process could be accelerated by heating, as chemical digestion reactions will approximately double in rate for every 10K increase in temperature.  So one mechanism is that Papain may break itself down quickly when heated.  The other is that at a high enough temperature, Papain may denature.