Synthesis Golf VII: (+)-Clopidogrel
This was a tricky synthesis. There were several issues. One is that the aryl glycine is possibly easy to epimerize, though the ortho substitution may help prevent that. One other major issue is that the thiophene is reducing and not compatible with any oxidative conditions and probably not compatible with electrophiles.

The amino acid moiety can be synthesized in several ways to set the stereogenic center. One is epoxide ring opening, but here I opted for an asymmetric Strecker reaction.

The six member ring was created via a [4+2] cycloaddition. This is probably the sketchiest portion of the synthesis.

The thiophene moiety was created using Paal-Knorr reaction with Lawesson reagent (B).

Detailed route:


imine formation
asymmetric Strecker with 5% PHTA (partially hydrolyzed titanium alkoxide) and 5% ligand (L). 1 eq tBuOH, tol. (Org. Lett., 2010, 12, 264.) Also, possible with Hoveyda type ligand: (JACS, 2000, 122, 2657.) This exact substrate is reported with good ee.
Hydrolysis with HCl. Similar route reported in (JACS, 1999, 121, 4284.) Though there, the authors Boc-protect at the end. We'll attempt to trap a different way...
formalin, toluene, pTsOH. reflux. Product imine is A.
LDA; TMSCl on methyl vinyl ketone to make electron rich diene.
Hopefully, a little heat will coax this [4+2] cycloaddition with A to take place.
Tsuji-Trost allylation is established for these types of TMS-protected enol ethers. Conditions are $\ce{Pd_{3}(dba)_{2}}$, DPPE, allyl methyl carbonate, THF. (Chem Lett., 1983, 1325.) We'll carry both diastereomers forward.
$\ce{O3}$; DMS.
Lawesson reagent (B).