Is it safe to lyophilize/Freeze-dry a chelated compound?
Lyophilization is regarded safer as normal drying because it is performed at considerably lower temperature; however in order to achieve this, you have to lower the pressure above the condensed phase, too.  Naturally volatile compounds (including some organic compounds solid at room temperature) may sublime under these conditions, too; which may be hold for hours, even days to remove the water gradually.  This simultaneous process may lower the yield of isolated product.

Other light organic molecules (like methanol, ethanol, THF) equally may leave the vessel, too.  The complexation may be affected if leaving molecules were involved as part of the no-further specified chelate, too.