Skipping the defatting stage in extraction of alkaloids
One big risk with the method you propose is foaming and gellation turning your extractions into a huge mess.  Under basic conditions, the fats (e.g. triacylglycerols or TAGs) are likely to hydrolyze, forming carboxylate salts of fatty acids.  "Carboxylate salts of fatty acids" is a long way of saying soap.  These soap-like compounds could lead to excessive foaming or gellation of the sample, which will hinder phase separation and gunk up your apparatus.