Representing conformers using SMILES and Graph representations
For the SMILES strings as defined by Daylight, you can expect these representations tell about the molecular constitution plus information about ($E$/$Z$)- and CIP's $(R)$/$(S)$-configuration. But nothing about the conformation like the boat / twist form of cyclohexane which generally is dynamic, or a faithful preservation of information like s-cis to describe the conformation of butadiene favorable for the Diels-Alder cycloaddition reaction.
Further, I speculate SMILES strings are not a faithful representation of locked conformations as in the axial $P/M$ configuration of 2,2',6,6'-substituted 1,1'-biphenyls. However, perhaps someone else may clarify this point.