Pauli's Exclusion Principle
I think you've misunderstood, Pauli's exclusion principle doesn't mean that the four numbers are different it means that no electron can have the same respective values for $n$, $l$, $m_s$, $m_l$ as another electron (in some case some of the numbers themselves can be the same). i.e. electrons in the same suborbital must have different spins.


$n$ indicates the orbital shell
$l$ indicates the type of suborbital, s, p etc
$m_l$ indicates the orientation of the suborbital, px, py etc
$m_s$ indicates the electron spin


Pauli's exclusion principle means that no electron around an atom can occupy identical orbitals, i.e two electron with up spin in a 2s1, as all their electron numbers would be the same as their respective equivalents ($n_1 =n_2 = 2$, $l_1 = l_2 = 0$, $m_{l,1} = m_{l,2} = 0$,  $m_{s,1} = m_{s,2} = -1/2$).