How would you Synthesise LY-293,284?
If you look at Eli Lilly patents and other literature, there doesn't seem to be a simple synthesis... I've put together an example of how it could be done. Although there are many ways you could go depending on starting materials, this way is based primarily on literature reactions with the exception of the last 3 steps which are Eli Lilly patents. I stopped after about 16 steps as I think that's more than enough to demonstrate how complex these designer molecule syntheses can be. I also left out reagents/reaction conditions just to show the general pathway, and to save on eye strain.



So really the simplicity (or complexity) will depend on where you are able to start on the synthetic pathway (e.g. what starting materials are available to you).