Model of London forces and Hydrogen Bonding; the question is carried on forward, partially, as a personal question, from another question
If i underatabd correctly,
Now a days when in molecular dybamics simulation or docking studies, to calculate everything requires precise knowledge of polar, hydrophobic, ionic and non-bonding interactions. We have models to deal with each, and each has limitations. With polar groups the issues are not so much the models, which have distance dependance and orientation dependance, but computer power. This is really what limits the models. Often solvent effects and hydrophobic effects are ignored or estimated and simplified.

If there is a model missing is a hydrophobicity model. There isn't anything that is super.