Significance of single point energy when calculating interaction energies
Single point energy arises in the framework of the Born–Oppenheimer approximation and corresponds to just one point on the potential energy surface. Physically it is the total energy of the molecular system with its nuclei beeing fixed (or clamped) at some particular locations in space. In other words, it is total energy of the molecular system within the so-called clamped nuclei approximation. 

Mathematically, if you develop the Born–Oppenheimer approximation step-by-step you can easily see that single point energy it is the sum of the electronic energy and nuclear repulsion potential energy,
$$
U = E_{\mathrm{e}} + V_{\mathrm{nn}} \, ,
$$
where the electronic energy $E_{\mathrm{e}}$ is the solution of the electronic Schrödinger equation,
$$
    \hat{H}_{\mathrm{e}} \psi_{\mathrm{e}}(\vec{r}_{\mathrm{e}}) = E_{\mathrm{e}} \psi_{\mathrm{e}}(\vec{r}_{\mathrm{e}}) \, .
$$
The fact that at this point we use the symbol $U$ which (alongside with $V$) is usually used for potential energy to mean the single point energy is justified a little later. Namely, when we introduce the Born-Oppenheimer approximation which give rise to the nuclear Schrödinger equation,
$$
    \Big( \hat{T}_{\mathrm{n}} + U(\vec{r}_{\mathrm{n}}) \Big) \psi_{\mathrm{n}}(\vec{r}_{\mathrm{n}}) = E \psi_{\mathrm{n}}(\vec{r}_{\mathrm{n}}) \, ,
$$
it is easy to recognize that the values of the single point energy $U$ for all possible nuclear configurations define the potential energy for nuclear motion. So, it is in this sense that the single point energy is related to the potential energy.



Update: it became clear that OP misunderstood the notion of the single point energy $U$. Indeed, once we do few single point calculations for different nuclear configurations, the resulting $U(\vec{r}_{\mathrm{n}})$ is the potential energy for nuclear motion. However, it is not the interaction energy between some fragments, though, the interaction energy contributes to it. So if one wants to obtain the interaction energy one has to decompose the potential energy $U(\vec{r}_{\mathrm{n}})$ into its parts.

There different ways to perform the energy decomposition, just to name a few without any particular order:


SAPT (Symmetry-Adapted Perturbation Theory) a separate program (few of them, to be more precise) which can be interfaced with different quantum chemistry codes.
NEDA (Natural Energy Decomposition Analysis) which is available as a part of NBO package.
Morokuma decomposition already available in some quantum chemistry codes (GAMESS-US, for instance).
LMO-EDA (Localised Molecular Orbital Energy Decomposition Analysis) also available in some quantum chemistry codes (GAMESS-US, for instance).