What is the meaning of the slope in a graded dose-response curve?
Since the drug concentration axis is logarithmic, even a small change in the nominal drug concentration can have a large effect if the slope is steep, so getting the correct dosage could be problematic. Accordingly, this requires care in drug concentration preparation and, in particular, it might make it harder to avoid overdoses.
For a shallow slope, a relatively large change in drug concentration may be needed in order to achieve the desired result. But side effects of the drug do not necessarily follow the same dose response relationship. So increasing dosage by a factor of 10, for example, might pose a much higher than factor of 10 risk of side effects.