Could dust blown up by a comet impact render the air unbreathable?
That doesnt seem realistic since eventually all the dust from all the volcanic activity, as well as that caused by our doing, eventually makes its way back down to earth. Most dust particles end up being soaked up by earths cloud layer coming down in rain. I have to agree with Gimelist but volcanism can and has produced conditions you mentioned by expelling caustic and poisonous gases and for what I understand nuclear detonations and the radioactive dust they send into the air is far worse in the long run.