Every 202,500 years, Earth wanders in a new direction; does it affect climate?
Milankovitch cycles do affect climate on Earth. There are several cycles. 


  "Variations in eccentricity, axial tilt, and precession of the Earth's
  orbit resulted in cyclical variation in the solar radiation reaching
  the Earth, and that this orbital forcing strongly influenced climatic
  patterns on Earth."
  source: wikipedia


Scientists of Pleistocene's climate evolution strongly correlate Milankovitch cycles with glacial/interglacial periods, affecting the Gulf Stream Current.
Other factors of Earth's internal system, such as volcanic events do affect climate, but changes in the magnitude of solar radiation are a well known climatic variability generator.