Running scikit-learn with large volume
There are multiple possiblities from dusk, to others model etc.
Here are my 2 favorites, not to loose you in the number of possibilities:

www.h5py.org/ &quot;It lets you store huge amounts of numerical data, and easily manipulate that data from NumPy. For example, you can slice into multi-terabyte datasets stored on disk, as if they were real NumPy arrays. Thousands of datasets can be stored in a single file, categorized and tagged however you want.&quot;

Try online learning with Cousin models of random forest (light-gbm). He has online learning capabilities.