How to create interactive plot of thousands of images as output of t-SNE?
It is certainly possible to create interactive plots of many thousands of images, as Google has done in their interactive art t-SNE Map.

However, as far as I have found, there is not any canned way to do this.  https://github.com/YaleDHLab/pix-plot is an open source application that also does an impressive job at plotting thousands of images, and if you are using python (e.g. with scikit-learn's t-SNE), it does not look too bad to modify to your use case.