title_body: Using 'splenda' in Vodka infusions. Serious headache!
upvoted_answer: Certain people can have very individualistic headache triggers. For me it is second hand smoke. There are quite a few references on the internet tying Splenda to migraines so perhaps it so for you, at least in combination with alcohol. In any case, I'd pitch your experiment. Vodka typically has 65 calories per ounce. Sugar is about 111. However, you probably don't add that many ounces of sugar to your bottle of vodka so most of the calories will come from the ethanol. Some people substitute agave nectar which supposedly has a lower glycemic index than granulated sugar and may be healthier.