title_body: Fixed Layout vs Reflowable For A Puzzle e-Book
upvoted_answer: I'm not answering the main part of your question, which is what are the capabilities of fixed layout ebooks. I think someone with a moderate amount of experience on reflowables could do a reflowable version provided that readers were informed to use a minimum screen resolution (768 pixels width?) and not  use devices older than K4. 
  
  Fyi there is an issue with  Google Play Books which does not honor this bit of code: 
  
  img {
  page-break-after: always !important;   
  }
  
  
  That makes it impossible to do a page break using css alone in Google Play Books. I'm pretty sure this code works on Kindle devices and other reading systems though. 
  
  For a reflowable book, you probably could use css media queries to ensure that each display size works on Kindle. The css breakpoints I use are 320-767px width (both portrait and landscape), 768-1500 (landscape), 1500+ (landscape), 768-1024 (portrait) and 1025+ (portrait). You should use high resolution images and then let Kindle downsize them when needed. Each css media query should specify a different size for the div container which contains the image. 
  
  On Kindle the css max-width isn't supported, so I use the code here: https://kdp.amazon.com/community/thread.jspa?messageID=1005910
  
  If you do reflowable, you could declare that ebook is only for tablets and not for phones (that's the easiest thing!). For smaller screens you could split the content into 2 screens, but it wouldn't be optimal. 
  
  A lot of testing would be involved, but it wouldn't be impossible.