Limits of a singular Docker Swarm stack
I would say It depend on you preference since redeploying a stack for only 1 or so image, will not restart all the containers present.

In the other hand network feature since docker 17.06 are reusable between stack with the attachable mode so you could easily separate the layers of your app while keeping them on the same sub-network (for usage like traefik or private data network).

Frankly for me this is the same problem as in dev when you separate the functions you are defining so it's easier for the others devs to understand a file of 50 lines compare to a file of 500 lines.

In the end it also depend on how this is integrated with your CD and if it's painful to update one document or multiple document when adding/removing services.

Personally I would go with multiples stack files.