Paginate entries with offset / limit when templating
You could use Twig's Slice function. 

{% set firstTwo = paginatedEntries|slice(0,2) %}
{% set lastFour = paginatedEntries|slice(2,4) %}


Then loop over firstTwo for your first items. 

{% for entry in firtTwo %}
   {# Show first 2 entries #}
{% endfor %} 


Loop over lastFour for your final items.

{% for entry in lastFour %}
   {# Show next 6 articles #}
{% endfor %}