How are people organizing their global sets?
Before I create any fields I try to plan them on paper. This helps me to create my first logical groups. It doesn't prevent changes later on, but at least reduces them a little.

Also all my global sets have prefix: global__settings, global__misc...

Now if I have to create a new set and move some fields, I can do a "Search &amp; Replace" on all templates, and thanks to the prefix I don't have to worry about replacing the wrong variables.