Spartanburg is included in the Metropolitan Statistical Area Greenville , which is also included in the Union County -- Spartanburg , SC -- Anderson , SC Combined Statistical Service . Spartanburg is included in the Greenville Metropolitan Statistical Area , which is also included in the Union County -- Spartanburg , SC -- Anderson , SC Combined Statistical Area . Union County is included in Spartanburg , SC Metropolitan Statistical Area , which is also included in the statistical area combined in Greenville - Spartanburg - Anderson , SC .