Major League Baseball and 12 players have agreed to 50-game suspensions for their roles in the Biogenesis case, multiple media outlets reported Monday, with the harshest penalty, against Alex Rodriguez, set to be handed down in the afternoon. 
 
 Rodriguez will be suspended through the end of the 2014 season in an announcement to come at 3 p.m. ET, sources told ESPN's T.J. Quinn. Rodriguez is expected to appeal and will be allowed to play until his appeal is heard. 
 
 The players' union made a late appeal to MLB for a deal for Rodriguez but was told there would be no more negotiations. He will be punished under the Joint Drug Agreement and other areas of the league's collective-bargaining agreement but will be allowed to play while he appeals. 
 
 The other players, initially confirmed by FoxSports.com, who have agreed to the suspensions without the right to appeal are: 
 
 [+] Enlarge Tom Pennington/Getty Images Rangers All-Star outfielder Nelson Cruz was among 12 players who agreed to 50-game suspensions for their roles in the Biogenesis case. 
 
 • Nelson Cruz, Rangers outfielder 
 
 • Everth Cabrera, Padres shortstop 
 
 • Jhonny Peralta, Tigers shortstop 
 
 • Antonio Bastardo, Phillies reliever 
 
 • Francisco Cervelli, Yankees catcher (on DL) 
 
 • Jordany Valdespin, Mets outfielder (minors) 
 
 • Jesus Montero, Mariners catcher (minors) 
 
 • Cesar Puello, Mets outfielder (minors) 
 
 • Sergio Escalona, Astros pitcher (minors) 
 
 • Fernando Martinez, Yankees outfielder (minors) 
 
 • Fautino De Los Santos, free-agent pitcher 
 
 • Jordan Norberto, free-agent pitcher 
 
 Beyond Rodriguez, the suspensions come with potentially stiff consequences for at least two of the players and their teams. Cruz, Cabrera and Peralta were each All-Stars this season, with Cruz's Rangers and Peralta's Tigers contending for playoff berths. 
 
 Milwaukee outfielder Ryan Braun was the first player to reach an agreement with MLB on a suspension for his connection to the Biogenesis case. The 2011 NL MVP accepted a season-ending 65-game suspension last month. 
 
 The Yankees have said they expect Rodriguez to be accused of recruiting other athletes for the clinic, attempting to obstruct MLB's investigation and not being truthful with MLB in the past when he discussed his relationship with Dr. Anthony Galea, who pleaded guilty two years ago to a federal charge of bringing unapproved drugs into the United States from Canada. 
 
 The Yankees also expect Rodriguez to be eligible to play Monday night, sources told ESPN The Magazine's Buster Olney, because they expect his suspension to be tied solely to a drug-policy violation and thus eligible to be appealed. 
 
 Evan Longoria, the Tampa Bay Rays' three-time All-Star third baseman, weighed in on the news of the suspensions via Twitter: 
 
 Today is a sad day for MLB,the fans of this great game, and all players who may have been negatively affected by others selfishness... — Evan Longoria (@Evan3Longoria) August 5, 2013 ||||| Twelve players have accepted 50-game suspensions for violating baseball’s drug policy, Ken Rosenthal reports, citing sources. 
 
 Shortly after, it was announced that Yankees star Alex Rodriguez has been suspended through the 2014 season. 
 
 Rangers outfielder Nelson Cruz, Tigers shortstop Jhonny Peralta, Phillies reliever Antonio Bastardo, Mets outfielder Jordany Valdespin, Padres shortstop Everth Cabrera, free-agent pitcher Jordan Norberto, Yankees catcher Francisco Cervelli, Mariners catcher/designated hitter Jesus Montero, Mets outfielder Cesar Puello, Astros minor league reliever Sergio Escalona, Padres minor league reliever Fautino De Los Santos and Yankees minor league outfielder Fernando Martinez have accepted their punishments handed out by Major League Baseball based on findings in its investigation of the Biogenesis anti-aging clinic in Coral Gables, Fla. 
 
 Norberto’s suspension will be effective immediately once he signs with another Major League organization. All other suspensions are effective immediately. 
 
 The clinic and its founder, Anthony Bosch, are alleged to have provided performance-enhancing drugs to major league players, as well as athletes in other sports. 
 
 Milwaukee Brewers outfielder Ryan Braun accepted a 65-game suspension on July 22 and will not play the remainder of this season. 
 
 Athletics pitcher Bartolo Colon, Blue Jays outfielder Melky Cabrera and Padres catcher Yasmani Grandal — who were all named in Biogenesis documents — have each served a 50-game suspension following a positive test. They will receive no additional punishment. Colon and Cabrera served their suspensions during the 2012 season; Grandal served his at the beginning of this season. 
 
 Nationals starting pitcher Gio Gonzalez and Orioles third baseman Danny Valencia, who both were named in media reports on the investigation, were cleared of any involvement. 
 
 The suspended players will not be paid while they serve out their bans. 
 
 Cruz, 33, was the MVP of the 2011 ALCS became an All-Star for the second time last month. Cruz is eligible for free agency after this season. He leads second-place Texas with 27 homers and 76 RBI this year. Salary lost: $2,732,240 plus the opportunity to earn $500,000 in performance bonuses based on plate appearances. 
 
 Cruz blamed his failed test as the rest of an "error in judgmen" following a stomach virus. 
 
 "From November, 2011 to January, 2012, I was seriously ill with a gastrointestinal infection, helicobacter pylori, which went undiagnosed for over a month," he said in a statement. "By the time I was properly diagnosed and treated, I had lost 40 pounds. Just weeks before I was to report to spring training in 2012, I was unsure whether I would be physically able to play. Faced with this situation, I made an error in judgment that I deeply regret, and I accept full responsibility for that error. I should have handled the situation differently, and my illness was no excuse. I am thankful for the unwavering support of my family, friends, and teammates during this difficult time. I look forward to regaining the trust and respect of the Rangers organization, my teammates, and the great Rangers’ fans, and I am grateful for the opportunity to rejoin the team for the playoffs." 
 
 Peralta, 31, made his second All-Star team this year and is set to become a free agent at the end of the season. Detroit exercised a $6 million option to keep him for 2013. He is batting .305 with 11 home runs and 54 RBIs. Salary lost: $1,639,344. 
 
 "In spring of 2012, I made a terrible mistake that I deeply regret," Peralta said in a statement. "I apologize to everyone that I have hurt as a result of my mistake, including my teammates, the Tigers’ organization, the great fans in Detroit, Major League Baseball, and my family. I take full responsibility for my actions, have no excuses for my lapse in judgment and I accept my suspension. I love the fans, my teammates and this organization and my greatest punishment is knowing that I have let so many good people down. I promise to do everything possible to try and earn back the respect that I have lost." 
 
 
 
 Bastardo, 27, is 3-2 with two saves and a 2.32 ERA this season. He hadn't previously been linked to the Biogenesis scandal or performance-enhancing drugs. He has pitched for five seasons with the Phillies in several roles. Salary lost: $382,514. 
 
 Everth Cabrera, 26, is a switch-hitter who is one of the top base stealers in the big leagues. He's making $1,275,000 this season. He was the lone All-Star from the struggling Padres, but didn't get into the game. He is hitting .283 and leads the National League with 37 steals. Salary lost: $348,361. 
 
 Cervelli, 27, has been on the disabled list since breaking his right hand when it was hit by a foul ball April 26. Cervelli has said he consulted with Biogenesis after a foot injury in 2011 but did not receive any treatment from the facility. When he got injured he was hitting .269 with three homers and eight RBI in 52 at-bats. Salary lost: $140,806. 
 
 Montero, 23, was considered one of the top prospects in baseball after a brief stint with the Yankees at the end of 2011. He played in 29 games before being demoted to the minors in late May and had barely settled in at Tacoma when he sustained a left knee injury that required surgery. Salary lost: $79,820. 
 
 THE PED SHUFFLE Some big-time contenders — like the Rangers — were hit hard by the Biogenesis suspensions. What Some big-time contenders — like the Rangers — were hit hard by the Biogenesis suspensions. What will they do now 
 
 Valdespin, 25, reached the majors last year. Unpopular in the clubhouse, he was hitting .188 with four home runs and 16 RBI in 133 at-bats when he was demoted to Las Vegas last month. He's batting .466 with three homers and 24 RBI in 16 games at Triple-A. Salary lost: $61,773. 
 
 Puello, 22, has been in the Mets' minor league system since 2008. Considered a top prospect, he has been on the 40-man roster since November 2011 but has not made his major league debut. He is hitting .328 with 16 homers, 73 RBI and 24 steals this season at Binghamton. Salary lost: $21,831. 
 
 Escalona, 29, was the winning pitcher in his major league debut, throwing a scoreless inning for Philadelphia in 2009. Escalona missed the entire 2012 season while recovering from Tommy John surgery and returned this year, going 1-2 with a 6.60 ERA in 12 minor league games. 
 
 De Los Santos, 27, went 0-1 with a 3.86 ERA in two relief appearances for Triple-A Tucson (PCL) before he was released on May 15. 
 
 Martinez, 24, was sent outright to the minors in May and was traded to the Yankees in June for minor league right-hander Charles Basford. 
 
 Norberto, 27, appeared in three games for the Triple-A Sacramento River Cats, allowing six runs and walking seven in 1 1/3 innings before being placed on the disabled list April 13 with a strained left elbow. He was released on May 8. 
 
 (The Associated Press contributed to this report.)
– All players targeted for drug suspensions in the Biogenesis scandal—except Alex Rodriguez—have accepted 50-game penalties from Major League Baseball, a person familiar with the negotiations tells the AP. MLB has decided to slap Rodriguez with a suspension lasting through the entire 2014 season, but he's expected to appeal, and will be allowed to keep on playing until that appeal is finished, sources tell ESPN. All-Stars Nelson Cruz of Texas, Jhonny Peralta of Detroit, and Everth Cabrera of San Diego are among the 12 who accepted penalties, the person said. Notably absent from the list are Bartolo Colon and Melky Cabrera, who according to Fox Sports are getting credit for the 50-game suspensions they each served last season after positive drug tests. Washington star Gio Gonzalez and Orioles third baseman Danny Valencia, meanwhile, were cleared of wrongdoing. The full list of suspended players is: Nelson Cruz, OF, Texas Jhonny Peralta, SS, Detroit Everth Cabrera, SS, San Diego Francisco Cervelli, C, New York Yankees Fernando Martinez; OF, New York Yankees Antonio Bastardo, P, Philadelphia Jesus Montero, C, Seattle Jordany Valdespin, IF, New York Mets Cesar Puello, OF, New York Mets Sergio Escalona, P, Houston; Fautino De Los Santos, P, San Diego Jordan Norberto, P, Free Agent