ation and management of the system highly complex, expensive, and ineffi- cient. In addition, many studies have shown that fixed spectrum allocation is wasteful since the license holders do not utilize the full spectrum continuously. Thus, to guarantee the required performance for each individual use case, the physical layer (PHY) configurations should be delicately optimized and medium access control (MAC) layer radio resources should be allocated on demand. Radio access network (RAN) slicing is proposed to efficiently support all the aforemen- tioned scenarios. RAN slicing enables design, deployment, customization, and optimization of isolated virtual sub-networks, or slices on a common physical network infrastructure, as such, to accommodate all fifth generation (5G) vertical industries like massive Internet of Things (IoT) and vehicle-to-everything (V2X) communications. From the radio perspec- tive, one viable RAN solution to support diverse requirements in 5G-and-beyond systems is to multiplex multiple types of services in one baseband system in orthogonal time and/or frequency resources, with either physical (e.g. using guard interval or guard band) or algo- rithmic (e.g. filtering or precoding the data) isolation to avoid/alleviate the interference between them. Frequency division multiplexing (FDM) is preferred in Third Generation xviii Preface Partnership Project (3GPP) for multiplexing different services due to several advantages such as forward compatibility and ease of supporting services with different latency require- ments. With such desired degree of freedom (DoF) for RAN slicing, it is expected to reap the diversity gain by optimizing air interface of individual slices. However, cohabitation of the individually optimized services, each with a different numerology Each numerology is defined by a set of parameters for the multicarrier waveform such as subcarrier-spacing, symbol-length, and the length of cyclic prefix., in one system leads to several technical challenges to both physical and multipl