hallenge. Applications and services that are used when designing a solution may become outdated by the time of deployment. Marginal services might gain some time in the lime light due to changes that cannot be foreseen, like the sudden popularity of some particular applications in the market or when new user equipment is introduced that seemingly increases traffic of a particular type. Being watchful for such applications is important, because usage profiles should definitely be taken into consideration when designing a solution. This chapter will cover some of the traditional challenges that are encountered in LTE deployments when taking into account the nature of business, technology, and user equipment. We will then shift our focus toward traffic and user profiles. We also highlight some futuristic trends that would necessitate certain requirements of 4G solutions in these areas to help prepare for these types situations in a more efficient manner. Technology-Related Challenges LTE as a technology has been adopted widely around the world. Yet the issues presented here pretty much remain active and need to be taken into account for a practical assessment of deployment issues, even if they are only partially addressable in implementation solutions. Interference Issues LTE as a solution has been designed to improve capacity and provide higher speeds at better QoS. Higher capacity mostly equates to higher transmission power and places a lot of importance on power control SO that cell edge users do not face too much interference. The farther the UE is from the eNodeB, the higher the power with which it needs to be transmitted. Also, even with the hierarchical layering of cells using different cell sizes (Macro, Pico, and Femto), interference still needs to be managed, both between the LTE cells and in an LTE cell (intracell interference) and with other radio access technologies that may exist (2G or 3G cells). Thus, intercell interference definitely increases in such scenarios. The tuning of such parameters in real