inaro1 and Vincenzo Sciancalepore² 1 Dipartimento DIIES, Università Mediterranea di Reggio Calabria, Via Graziella, Italy 2E Laboratories Europe GmbH, Heidelberg, Germany 13.1 Introduction Fifth generation (5G) systems are envisioned to support enhanced mobile broadband com- munication services as well as a flurry of new use cases from vertical industries. Among them, the automotive vertical is considered an undoubted key driver of 5G systems because of the ongoing technological transformations in the field of communication, automation, sensing, and positioning, which are expected to revolutionize future transportation and quality of life. Vehicle-to-everything (V2X) communications play a crucial role in enabling the exchange of information to support different applications, which range from cooperative autonomous and tele-operated driving to traffic efficiency and infotainment services, including adver- tisements as well as software updates and diagnostics [1]. Owing to their heterogeneity, vehicular applications bring about a plethora of connectivity requirements. Most of them are particularly challenging, i.e. ultralow latency (below 10 ms), ultrahigh reliability (near 100%), and high data rate (in the order of Gbps), and their fulfillment is further exacerbated by the high mobility and density of vehicles. Thus, the one-size-fits-all design philosophy applied in existing networks is not flexible and scalable enough for the simultaneous support of a diversified set of V2X applications, in terms of performance, security, availability, and cost. Network slicing has been recently proposed by academia and industry in the 5G research arena as a promising approach to fulfill divergent service requirements in a flexible way, as analyzed in [2]. Network and computing resources can be tailored to specific service needs on a common programmable end-to-end network infrastructure, by logically isolating control plane (CP) and user plane (UP) network functions. UP and CP functionalities of different slices can be virtualiz