There are eighteen universities in Santo Domingo . Established in 1538 , Universidad AutÃ noma de Santo Domingo ( UASD ) was the first university founded in the continent ; it is also the only public university in the country . Some of the stops on the first line are the Teatro Nacional , the main campus of the Universidad AutÃ noma de Santo Domingo ( UASD ; Autonomous University of Santo Domingo ) and Avenida Lincoln .