Anna Maria Luisa was the only daughter of Cosimo III de ' Medici , Grand Duke of Tuscany , and Marguerite Louise d'Orl Ã ans , a niece of Louis XIII of France . Anna Maria Luisa de ' Medici , the only daughter and second child of Cosimo III de ' Medici , Grand Duke of Tuscany , and his consort , Marguerite Louise d'Orl Ã ans , was born in Florence on 11 August 1667 .