From 1923 to 2008 , the Yankees home stadium had been Yankee Stadium . To celebrate the final year and history of Yankee Stadium , the 2008 Major League Baseball All-Star Game was played there on July 15 , 2008 . The final regular-season game at Yankee Stadium was played on September 21 , 2008 against Baltimore , the city from which both the Yankees and their great star Babe Ruth originated .