The first orbital flight of the X-37B , was launched on an Atlas V rocket at Cape Canaveral Air Force Station , Florida in April 2010 . The first orbital flight of OTV-1 , the first X-37B , with a mission name of USA-212 , was launched on an Atlas V rocket at Cape Canaveral Air Force Station , Florida on 22 April 2010 , at 23:58 GMT .