Florence Harding ( August 15 , 1860 - November 21 , 1924 ) was the wife of Warren G. Harding , the President of the United States . She acted as the First Lady of the United States from 1921 to 1923 . Florence Mabel Kling `` Flossie '' Harding ( previously DeWolfe ; August 15 , 1860 , Marion , Ohio -- November 21 , 1924 ) , wife of President Warren G. Harding , was 31st First Lady of the United States from 1921 to 1923 .