With that division , many parts of the old city are now part of the Santo Domingo Province and not of the city of Santo Domingo de GuzmÃ n. But they are still part of the metropolitan area of the city ( the Greater Santo Domingo ) . They consist of Santo Domingo de GuzmÃ n National District and three municipal divisions of Santo Domingo Province : Santo Domingo Norte ( Villa Mella Municipal District , etc. ) , Santo Domingo Este ( San Isidro Municipal District , etc. ) , and Santo Domingo Oeste . These three border Santo Domingo de GuzmÃ n on the north , east , and west , respectively .