U.S. Route 2 is considered a major U.S. Highway even though it does not end in `` 0 '' . U.S. Route 163 , U.S. Route 400 , U.S. Route 412 , and U.S. Route 425 have 3-digit numbers that do not act as a spur of a 1 or 2 digit route . In 1952 , AASHO permanently recognized the splits in U.S. Route 11 , U.S. Route 19 , U.S. Route 25 , U.S. Route 31 , U.S. Route 45 , U.S. Route 49 , U.S. Route 73 , and U.S. Route 99 .