With the painting Les Demoiselles d'Avignon 1907 , Picasso dramatically created a new and radical picture depicting a raw and primitive brothel scene with five prostitutes , violently painted women , reminiscent of African tribal masks and his own new Cubist inventions . With the painting Les Demoiselles d'Avignon ( 1907 ) , Picasso dramatically created a new and radical picture depicting a raw and primitive brothel scene with five prostitutes , violently painted women , reminiscent of African tribal masks and his own new Cubist inventions .