Codeine is often marketed as drugs in combination with paracetamol ( acetaminophen ) as co-codamol ( best known in North America as Tylenol 3 ) . Codeine is marketed as both a single-ingredient drug and in combination preparations with the analgesic acetaminophen ( paracetamol ) , as co-codamol , paracod , panadeine , or the Tylenol With Codeine series ( e.g. , Tylenol 3 and 4 tablets and elixir ) ; with the analgesic acetylsalicylic acid ( aspirin ) , as co-codaprin ; or with the NSAID ( non-steroidal anti-inflammatory drug ) ibuprofen , as Nurofen Plus .