jpg thumb ( 409x599 ) px right Cheryl Hines ) ) Cheryl Hines is an American actress and television director . She is most noted for playing Cheryl in the HBO show Curb Your Enthusiasm . Cheryl Hines ( born September 21 , 1965 ) is an American actress and television director , best known for her role as Larry David 's wife Cheryl on HBO 's Curb Your Enthusiasm .