Many interstate highways cross Queens , including I-495 ( the Long Island Expressway ) , I-278 ( the Brooklyn-Queens Expressway ) , and I-678 ( the Van Wyck Expressway , pronounced Van Wike ) . There are also several major north-south highways in Queens , including the Brooklyn-Queens Expressway ( Interstate 278 ) , the Van Wyck Expressway ( Interstate 678 ) , the Clearview Expressway ( Interstate 295 ) , and the Cross Island Parkway .