Roethlisberger led the Steelers to a second Super Bowl title in four seasons as they defeated the Arizona Cardinals in Super Bowl XLIII , 27-23 , after he made a game-winning touchdown pass to Santonio Holmes in the final 35 seconds . Roethlisberger led the Steelers to a second Super Bowl title in four seasons as they defeated the Arizona Cardinals in Super Bowl XLIII , 27 â `` 23 , after completing a game-winning touchdown pass to Santonio Holmes in the final 35 seconds .