Pethidine is also relatively bad for use when a patient is suffering from liver , or kidney disease , has a history of seizures or epilepsy , has an enlarged prostate or urinary retention problems , or suffers from hyperthyroidism , asthma , or Addison 's disease . Pethidine is also relatively contraindicated for use when a patient is suffering from liver , or kidney disease , has a history of seizures or epilepsy , has an enlarged prostate or urinary retention problems , or suffers from hypothyroidism , asthma , or Addison 's disease .