U.S. Route 66 ( also known as Route 66 , U.S. Highway 66 , The Main Street of America , The Mother Road and the Will Rogers Highway ) was a highway in the U.S. Highway System . One of the original U.S. highways , Route 66 , US Highway 66 , was established on November 11 , 1926 . Later , Route 66 was advertised by the U.S. Highway 66 Association as `` The Main Street of America '' .