Most of the cities of the Palatinate ( Ludwigshafen , Speyer , Landau , Frankenthal , Neustadt ) lie in the Rhineplain in the east . Most of the cities of the Palatinate ( Ludwigshafen , Speyer , Landau , Frankenthal , Neustadt ) lie in the plain rhine rift in the east of the region , near the Rhine River , which forms the eastern border of the Palatinate .