Karlsruhe is a city in the south-west of Germany , in the state of Baden-W Ã 1\/4 rttemberg . Karlsruhe has about 285,000 inhabitants and a Technical University . Karlsruhe is also the home of the Forschungszentrum Karlsruhe ( Research Center Karlsruhe ) , at which engineering and scientific research is performed in the areas of health , earth and environmental sciences , and Karlsruhe University of Applied Sciences ( Hochschule Karlsruhe-HS ) , the largest university of technology in the State of Baden-W Ã 1\/4 rttemberg , offering both professional and academic education in engineering sciences and business .