Some cities were founded after the War of Arauco : Santiago ( 1541 ) , La Serena ( 1544 ) , ConcepciÃ n ( 1551 ) , La Imperial , Valdivia , Villarrica ( 1552 ) , Los Confines ( 1553 ) , CaÃ ete ( 1557 ) , Osorno ( 1558 ) , Arauco ( 1566 ) , Castro ( 1567 ) , ChillÃ n ( 1580 ) and Santa Cruz de OÃ ez ( 1595 ) . The cities founded despite setbacks in the Arauco War were : Santiago ( 1541 ) , La Serena ( 1544 ) , ConcepciÃ n ( 1551 ) , La Imperial , Valdivia , Villarrica ( 1552 ) , Los Confines ( 1553 ) , CaÃ ete ( 1557 ) , Osorno ( 1558 ) , Arauco ( 1566 ) , Castro ( 1567 ) , ChillÃ n ( 1580 ) and Santa Cruz de OÃ ez ( 1595 ) .