WrestleMania 21 was the first WrestleMania held at the Staples Center , but the fifth to take place in the Southern California metropolitan area ( following WrestleMania 2 , WrestleMania VII , WrestleMania XII and WrestleMania 2000 ) . WrestleMania 21 was the first WrestleMania held at the Staples Center , but the fifth to take place in the Southern California metropolitan area ( following WrestleMania 2 , WrestleMania VII , WrestleMania XII , and WrestleMania 2000 ) .