At the 25th Anniversary of Wrestlemania Orton lost to Triple H in a title match . At WrestleMania , Orton retained the WWE Championship in a Triple Threat match involving Cena and Triple H. Orton won the match by pinning Cena after a Pedigree from Triple H. The following month , at Backlash , Orton lost the title to Triple H in a Fatal Four-Way Elimination match , which also included Cena and John `` Bradshaw '' Layfield . After failing to win the title back at Judgment Day , Orton faced Triple H in a Last Man Standing match at One Night Stand for the title .