The movie is about a spolied chihuahua from Beverly Hills named Chloe ( voiced by Drew Barrymore ) . Her owner , `` Aunt Viv '' ( Jamie Lee Curtis ) , has to go to Italy , so she leaves Chloe with her niece , Rachel Ashe Lynn ( Piper Perabo ) . Vivian Ashe ( Jamie Lee Curtis ) leaves her pet chihuahua Chloe ( Drew Barrymore ) with her irresponsible niece Rachel ( Piper Perabo ) .