Interstate 95 ( usually called I-95 ) is an important Interstate highway that runs north to south in the eastern part of the United States . Interstate 95 in North Carolina is one of four major north -- south corridors through the state ( the others being U.S. Route 220 ( Interstate 73 ) \/ U.S. Route 29 , Interstate 77 , and Interstate 26 ) . I-95 informally serves as separation between the piedmont and coastal plain regions of North Carolina .