Spokane is the main city for a large area including all of eastern Washington and northern Idaho . Spokane is located on the Spokane River in Eastern Washington , near the eastern border of Washington , about 20 m from Idaho , 110 m south of the Canadian border , 271 m east of Seattle , and 279 m southwest of Calgary . Spokane is part of the Inland Northwest region , consisting of eastern Washington , northern Idaho , western Montana , and northeastern Oregon .