text: Below is an context that describes a sql query, paired with an question that provides further information. Write an answer that appropriately completes the request.  # noqa: E501
  ### Context:
  CREATE TABLE medicine_enzyme_interaction (id VARCHAR, enzyme_id VARCHAR); CREATE TABLE enzyme (id VARCHAR, enzyme_id VARCHAR)
  ### Question:
  How many enzymes do not have any interactions?
  ### Answer:
  SELECT COUNT(*) FROM enzyme WHERE NOT id IN (SELECT enzyme_id FROM medicine_enzyme_interaction)