ELECTROENCEPHALOGRAPHIC AND BEHA VIORAL AROCSAL EFFECTS OF SMALL DOSES OF NICOTINE: ~EUROPSYCHOPHARMACOLOGICAL STCDY Edward Domino Department pf Pharmacology Th Uniunity o Michigan Ann Arbor; Michitan INTRODUCTION (n) cholinarric sronbt with wide Nicotine Bel knovo "picotonic' spread etfocts upon thc Jutopomic, Ieapinttory , 4nd neuromurular sytlemnt variety ot Peripberal perve Tocoptor; By virtue ol iu Ictions on c4ueut So prominant marked chantu in btart ntt, blood prettur mpintion. tba paripherl Ictiont ol aall dow ol nicotine that ju ellecu upop tbt: cebtra nervous tytttd huve burn nerkctedl uneppracinued by mott mver tnton intentted in the pharmacoloty of tobacco uokint: In mott Itudie urd, brctue the Lt tberr affectt dotat enoutb t b toric have beap veluabk phanatcolorical tool Ior ttudying cholinarric mechanimt drut cholineric tynaptic trant Small dotn nimukt and bre dortt block Many miction: ofthe]_nauropharmacologicul and]bebaviora studia vith tobacco nicotine, Uthourh of academic interett,_une clearly unrehted moking (Silvettadtal , 1982) . motivated in part by tht lct that it @ Our own bntartat nicotina cbolinerric uronists that can early penetrte the blood-bnin ot tbe Pyrolidine nitroten hut burier: At pH 74 tempentun of 37* tbe and 1985b) . The 315 be about  694" jnized (Domino, beto culculited not ionired Gn midily penetrat tht blood-bnin picotina mokculat that burrier. Althourh tbe ponionized molecules 4me the 0pax that penetnte into Mpontible pharmucolorical effocu vuriou tioauaa tba charzed for or the Hunilton; 1962; Burlow , 1985) . Tbeability of nicotine (Barlor Penatnu into ths &ntre] parvout tyttem hus been demonatrted dnmatically in both th mour &nd tht @t by Schmiterlov and Hanteon (1985) , Wting 4utondjo Penetrate retdily into Evan thourh the compound can raphic tachniquet detarmina iu direct Actiont upon tbe the bmain and tpinal cord, Ittamptt iu riderpred baurht with bechure cantru norvous syttem tor Peripherl 4utonomic ettectr Bectur rbtively sll dotet of: nicotine the Order of 540 MI/kt; produce dnmatic curdiovurcular eflecu unADer bave tended t minimd dotat mott]of thetized animak or mn; our #tuditr Bo305us2 Councl tr_Tobarro Rarturch US4 ud pnnu bom Panby USPHS 216
ELECTROENCEPHALOGRAPHIC AND BEHA VIORAL AROCSAL EFFECTS OF SMALL DOSES OF NICOTINE: ~EUROPSYCHOPHARMACOLOGICAL STCDY Edward Domino Department pf Pharmacology Th Uniunity o Michigan Ann Arbor; Michitan INTRODUCTION Nicotine Bel knovo "picotonic' (n) cholinarric sronbt with wide spread etfocts upon thc Jutopomic, Ieapinttory , 4nd neuromurular sytlemnt By virtue ol iu Ictions on variety ot Peripberal perve Tocoptor; c4ueut marked chantu in btart ntt, blood prettur mpintion. So prominant tba paripherl Ictiont ol aall dow ol nicotine that ju ellecu upop tbt: cebtra nervous tytttd huve burn nerkctedl uneppracinued by mott mver tnton intentted in the pharmacoloty of tobacco uokint: In mott Itudie tberr affectt dotat Lt enoutb t b toric have beap urd, brctue the drut veluabk phanatcolorical tool Ior ttudying cholinarric mechanimt Small dotn nimukt and bre dortt block cholineric tynaptic trant miction: Many ofthe]_nauropharmacologicul and]bebaviora studia vith nicotine, Uthourh of academic interett,_une clearly unrehted tobacco moking (Silvettadtal , 1982) . Our own bntartat nicotina motivated in part by tht lct that it @ ot tbe cbolinerric uronists that can early penetrte the blood-bnin burier: At pH 74 and tempentun of 37* tbe Pyrolidine nitroten hut beto culculited be about  694" jnized (Domino, 1985b) . The 315 picotina mokculat that not ionired Gn midily penetrat tht blood-bnin burrier. Althourh tbe ponionized molecules 4me the 0pax that penetnte into vuriou tioauaa tba charzed for Mpontible or the pharmucolorical effocu (Barlor Hunilton; 1962; Burlow , 1985) . Tbeability of nicotine Penatnu into ths &ntre] parvout tyttem hus been demonatrted dnmatically in both th mour &nd tht @t by Schmiterlov and Hanteon (1985) , Wting 4utondjo raphic tachniquet Evan thourh the compound can Penetrate retdily into the bmain and tpinal cord, Ittamptt detarmina iu direct Actiont upon tbe cantru norvous syttem baurht with tor bechure iu riderpred Peripherl 4utonomic ettectr Bectur rbtively sll dotet of: nicotine the Order of 540 MI/kt; produce dnmatic curdiovurcular eflecu unADer thetized animak or mn; bave tended t minimd dotat mott]of our #tuditr Panby pnnu bom Councl tr_Tobarro Rarturch  US4 ud Bo305us2 USPHS 216