78575 Snc Lo Lopynaald 1* Pergamor Printed in Ihc USA AItent{ (cicdeo 0i05-4604nS1700 PII SOH 4603(97101U41 5 COMPAKISON OF MEASURES USED TO ASSESS EFFECTIVENESS OF THE TRANSDERMAL NICOTINE PATCH AT1YEAR ROBYNL: RICHMOND Mcdicine; Untetsity c1 Newy South Wales Shocl Commun This TattCS bulinenct amonnu Yud:cs Icccrtinp Abslract _ cumie: oulcome masdermal pich u4inz dulcinl Mcjsurcs dueciivc- I2-mionth ouicore he niceln puhlichcd aandomizco contitolkcd sdics nporing Tni Vl Achictcu Telctn" Ihe nicalinc Iransdcgmal patch: Comparisons arc mnd: JcTcxs #ud- Lerear jsLincicc flcs cron nastincncc Doini Crevalcnce, comlinuausacu oicnmcntt Fiolongcd ntstir-nce. Sludizs Iat mncasured ouiccme Ierm' continm AntDIOncfO ahaincner rcunshu Fcd cuublc elicct Tonif-euve pilc CLtaeeo0 #Acernnor Whis difference not i/wn ppaten Fndst Stncs Uaine Danepreynlence Elivi ncamc menute smoking cessalion and arc Nicolinc transdeimal paiches Were deyeloped as an aid offcr an elficient method of delivering nicotine controlled and contin - designed uous way (Palmer. Buckley. Faulds, 1992} S0 that withdrawal symploms arc allevi spray) therapies (gumn ated; Compared other nicoiinc rcplacemenl And ie MtAs offer thc best risk-Lo-benelit Talio; they combinc gaod dermal pulches uppeul smoking cessalion ellicacy and withdrawal supprcssion with: modes adversc cllect prolile and low abuse liability Stiyzer; nigh compli Gross 989) Further. there ance and palient zcceplance of the patches compared the gum (Mendclsohn Richmond, 1994) smoking cessation Irials use one of three aler Criteria IOx reporting ahslinerce Thcy arc (a) point prevalence. the per- nalive outcom 1o cvaluale eflicaCY _ Measuc: smaking particular point time , includling; long-lelm #0d centagc people continucus abstinence, the most consetyalivc Incasure of cut- short-term quitlcrs;. pcople #ho have no smoked a sincc cnmninenc the percentage wch prolongcd absti to Ihe I2-month follow-up Point; and (C}n mnent of ihc intervention Percentagc who have been continuously abstinent for prolonged period nence. Snov. the previous (Velicer. Prochaska Rossi, 1902 The oul- sncr Fment proCe"ss Of slorping stok- come measure Of prolongcd abslinence rellects nalra quitting only aftcr experiencing scrics delayed quit some smiokers succced and Telapses (ollowing (Prachuska DiClcmenic. altempts, Japses Inenventon bstincnce not account (or this frequent occurrence 9861 Ithough continuous regarded as Ihe MOSI !igorous mneasure. as ab- in thc dynam tucess Of quitting; ol intervention: Thcrcfore considered direct gold stan Tesul stinence lidated continuous or prolonged smoking for presenting efficacy are ]2-month dards 1 lhese measures demonstrale slable ibstinerce over lime abstinence ralcs. meta-analysis 0f 17 clinical_trials of the nicotine [ransclermal USing absli ratch months found 22% aclive trealment 9% for placebo (adds ratio was nd nence uL Roby ckoua Richmun Schucl Commn uayMcdicin? Univcriy Kequed Sydnuy NSW 2052. Auslrslij SNcw CouWnk< EnviL nachmoneunucu.u
78575 Lopynaald 1* Snc Lo Printed in Ihc USA AItent{ (cicdeo 0i05-4604nS1700 Pergamor PII SOH 4603(97101U41 5 COMPAKISON OF MEASURES USED TO ASSESS EFFECTIVENESS OF THE TRANSDERMAL NICOTINE PATCH AT1YEAR ROBYNL: RICHMOND Shocl Commun Mcdicine; Untetsity c1 Newy South Wales Abslract _ This cumie: oulcome TattCS bulinenct amonnu Yud:cs Icccrtinp I2-mionth ouicore he niceln masdermal pich u4inz dulcinl Mcjsurcs dueciivc- Tni Vl Achictcu Telctn" puhlichcd aandomizco contitolkcd sdics nporing Lerear jsLincicc flcs Ihe nicalinc Iransdcgmal patch: Comparisons arc mnd: JcTcxs #ud- oicnmcntt cron nastincncc Doini Crevalcnce, comlinuausacu Fiolongcd ntstir-nce. Sludizs Iat mncasured ouiccme Ierm' continm AntDIOncfO ahaincner rcunshu Fcd cuublc elicct Tonif-euve pilc CLtaeeo0 #Acernnor Whis difference not i/wn ppaten Fndst Stncs Uaine Danepreynlence ncamc menute Elivi Nicolinc transdeimal paiches Were deyeloped as an aid smoking cessalion and arc designed offcr an elficient method of delivering nicotine controlled and contin - uous way (Palmer. Buckley. Faulds, 1992} S0 that withdrawal symploms arc allevi ated; Compared other nicoiinc rcplacemenl therapies (gumn And ie spray) MtAs dermal pulches uppeul offer thc best risk-Lo-benelit Talio; they combinc gaod smoking cessalion ellicacy and withdrawal supprcssion with: modes adversc cllect prolile and low abuse liability Gross Stiyzer; 989) Further. there nigh compli ance and palient zcceplance of the patches compared the gum (Mendclsohn Richmond, 1994) Criteria IOx reporting ahslinerce smoking cessation Irials use one of three aler nalive outcom Measuc: 1o cvaluale eflicaCY _ Thcy arc (a) point prevalence. the per- centagc people smaking particular point time , includling; long-lelm #0d short-term quitlcrs;. continucus abstinence, the most consetyalivc Incasure of cut- wch the percentage pcople #ho have no smoked a sincc cnmninenc mnent of ihc intervention to Ihe I2-month follow-up Point; and (C}n prolongcd absti nence. Percentagc who have been continuously abstinent for prolonged period sncr the previous Fment (Velicer. Prochaska Rossi, Snov. 1902 The oul- come measure Of prolongcd abslinence rellects nalra proCe"ss Of slorping stok- some smiokers succced quitting only aftcr experiencing scrics delayed quit altempts, Japses and Telapses (ollowing Inenventon (Prachuska DiClcmenic. 9861 Ithough continuous bstincnce not account (or this frequent occurrence in thc dynam tucess Of quitting; regarded as Ihe MOSI !igorous mneasure. as ab- stinence considered direct Tesul ol intervention: Thcrcfore gold stan dards for presenting efficacy are ]2-month lidated continuous or prolonged smoking abstinence ralcs. lhese measures demonstrale slable ibstinerce over lime meta-analysis 0f 17 clinical_trials of the nicotine [ransclermal ratch USing absli nence uL months found 22% aclive trealment nd 9% for placebo (adds ratio was 1 Roby ckoua Kequed Richmun Schucl Commn uayMcdicin? Univcriy SNcw CouWnk< Sydnuy NSW 2052. Auslrslij EnviL nachmoneunucu.u