CILIARY KINETICS ANI) GENETICS Afzelius, Ph,D. Bjorn A par Wenner-Gren Institute University of Stockholm pOI S-113 45 Stockholm, Sweden fort Ciliary  work   drives the mucociliary clearance mechanism  which acls as the first defense mechanism of the lungs_ It is possible to damage the cilia with adverse effects on clearance. Much speculation on the connection between impaired cilia and the has  been   made development   of  bronchitis or  airway obstruction. Only with thc syndrome, characterized by an inborn immotil: recent discovery of cilia, ity of the possible is it to study this connection rather than to speculate about it. Thc syndrome 'the immotile cilia syndrome called 1S characler- generalized congenital  immotility of the spermatozoa, ized by well as the cilia and results in chronic infections of the upper and lower airways and in infertility of thc male. Situs inversus occurs in The syndrome includes Kartagener' about half the cases_ syndrome but is not identical t0 it , By way of introducing some new concepts in the field of ciliary would like t0 make threc recommendations: kinetics and genetics, If a man has chronic sinusitis and bronchiectasis him to the send fertility clinic for check-up of the ejaculate. If spermatozoa are found t0 be immotile but otherwise normal, listcn Io the hcart_ If the heart is on the wrong side, find out whether the patient has decreased sense 0l smell These three recominendations no doubt appear bizarre when given will; however, proceed to show that without further explanation_ There is one factor in cOmmon, Or 50 rational  basis thcy have think : Cilia are   involved When   cilia   arc dcfcctivc spectrum of abnormalities will occur which can be diagnosed 5022 525
CILIARY KINETICS ANI) GENETICS Bjorn A Afzelius, Ph,D. par Wenner-Gren Institute University of Stockholm S-113 45 Stockholm, Sweden pOI fort Ciliary  work   drives the mucociliary clearance mechanism  which acls as the first defense mechanism of the lungs_ It is possible to damage the cilia with adverse effects on clearance. Much speculation has  been   made on the connection between impaired cilia and the development   of  bronchitis or  airway obstruction. Only with thc recent discovery of syndrome, characterized by an inborn immotil: ity of the cilia, is it possible to study this connection rather than to speculate about it. Thc syndrome called 'the immotile cilia syndrome 1S characler- ized by generalized congenital  immotility of the spermatozoa, well as the cilia and results in chronic infections of the upper and lower airways and in infertility of thc male. Situs inversus occurs in about half the cases_ The syndrome includes Kartagener' syndrome but is not identical t0 it , By way of introducing some new concepts in the field of ciliary kinetics and genetics, would like t0 make threc recommendations: If a man has chronic sinusitis and bronchiectasis send him to the fertility clinic for check-up of the ejaculate. If spermatozoa are found t0 be immotile but otherwise normal, listcn Io the hcart_ If the heart is on the wrong side, find out whether the patient has decreased sense 0l smell These three recominendations no doubt appear bizarre when given without further explanation_ will; however, proceed to show that thcy have rational  basis There is one factor in cOmmon, Or 50 think : Cilia are   involved When   cilia   arc dcfcctivc spectrum of abnormalities will occur which can be diagnosed 5022 525