Principal InvesliqaloriProgram Director (Last, Ist, mldle): BIOGRAPHICAL SKETCH Give the lolbwing information for the key personnel and consutlants and colaboralors Begin with Ihe principal invosligatorlprogram Grector. Pholocopy Ihis papo Ior Bach parson AME POSITION TITLE Takaai Salo Research Associale EDUCATION (Bogin Wiih baccalaureale %r olher Intul prolessbnal education; such tralnimg nursino andinclude Doskod0ra YEAR INSTITUTION AND LOCATION DEGREE CONFERREO FIELD OF STUDY University of Osaka, Japan Medical Schoo Ph.D: 1990 Cancer Genelics University ol Hokkaido , Japan Molecular Biobgy B.A; 1982 RESEARCH AND PROFESSIONAL EXPERIENCE: Conclud nJ with prosont posiilan, Fst, chronokolcal arder, Prev ous amployment exparience, Kev personnel inclde the princIpal investgalor and any Olhor indivduals who partcipate honors the scienul < develpmnt tte project AiEculon Key parsonnel typically will include all individua $ With doctoral other prolesskral Cegreos.but prolects will include individuals - the mastors Aeoad lovel provided thoy contribute Ihe sclarliic dovelopmanl 0 paccalu oaio subslanbvu way execution tho project Include present monborship on any Federal Governmont advisory commitlee. Lisl, in chronobgical order; the tiiles, ali aulhors, and complete re"eroncos Pube publications during the Ihioo Y0ars raprasunlabve eat Br paninent Io Ihis apollcation: DO NOT EXCEED TWO PAGES: Pust publicallon PRQEESSIONAL_EXPERIENCE 1982-1984 Researcher; Basic Research Labs Central Research Labs; Ajinomolo Co. Japan 1984-1988 Research Fellow, Dept. ol Molecular Genelics, Inst  of Molecular and Cellular Bio Osaka Univ , Japan visiting Scientist, Center for Cancer Research 1988-1989 Massachusetls Institule of Technolgy, MA 1989-1992 Assocale Scienlilic Stall , Dept, ot Biochemisiry, Cancer Institule Tokyo, Japan Research Associate, La Jolla Cancer Research Foundation; La Jolla 1992-presenl CA (lab 0l Dr. J.C. Reed) PUBLICATIQNS Sato, T,, el al, (1992). The human prohibitin gene located on chromosome 17921 is mulaled sporadic breast cancer. Cancer Res ,52 , 1643-1646 Takila Sato, et al, (1992). Correlation loss ol alleles on Ihe shor arms of chromosome 11 and 17 with Cancer Res , 52, 3914-3917 metasiasis ol prmary breast cancer; Sato et al, (1991). Accumulation of genelic allerations and progression primary breast cancer. Cancer Res 5794-5799 Sato et al, (1991). Alleltype ol human ovaran cancer. Cancer Res;, 51, 5118-5122. et al, (1990). Allelotype of breast cancer: Sato Cumulative allele lsses promole lumor progression in primary 50, 7184-7189 breast cancer. Cancer Res. Yamakawa K , Takahashi; E Sailo H,, Sato et al, (1991). Isolation and mapping 0l 75 new DNA markers on human chromosome Genomics; 9. 536-543_ Sato et al, (1989). The contormation ol malure a-amylase conditions ils secretion Irom yeast. Gene, 83,355 365 Izumolo Sato, et al, (1987). Expression of human pancrealic secrelory Irypsin inhibilor (PSTI) in SaccharQmvces cerevisiae Gene, 59, 151-159 Morinaga Y,, Takagi; H: Miwa, K, et al, (1987).   Threonine produclion by co-exislence of Ishida Salo, T. cloned gones coding homoserine dehydrogenase and homoserne kinase in Brexibacterium laclolermenlud Agric. Biol. Chem , 51 93-100 . Sato et al, (1987). New approach ol the high-level expression human IL-? cDNA in Ecoli J. Biochem: _ 101, 525-534. Hatakeyama Taniguchi, T,, Fujita Mori, H: Malsui; H; Salo el al, (1986). Interleukin 2 its receplor: and slructure and Iunctional expression of the genes Cold Sprig Harbor Symposia on Quantalive Biology; LL, 577- 586 Nakamura, Y. Salo et al, (1986). Expression of human salivary a-amylase gene in Saccharomyces crevisiae and Ils secrelion using Ihe mammalian signa sequence . Gene, 50,239-245_ Sato, Expression et al, (1986) Ihe human salivary   a-amylase gene in yeast and characterization ot Ihe secreted protein: Gene, 50 247-257 . PHS 398 (Rev: 9,91) (Form Page , Pege Njmbar p33as conenautvey 8: Ihe botlom broughout Ihe Aaplcain nollse AL tlixes *ua$ Ja, 30.
Principal InvesliqaloriProgram Director (Last, Ist, mldle): BIOGRAPHICAL SKETCH Give the lolbwing information for the key personnel and consutlants and colaboralors Begin with Ihe principal invosligatorlprogram Grector. Pholocopy Ihis papo Ior Bach parson  AME POSITION TITLE Takaai Salo Research Associale EDUCATION (Bogin Wiih baccalaureale %r olher Intul prolessbnal education; such nursino andinclude Doskod0ra tralnimg  YEAR INSTITUTION AND LOCATION DEGREE CONFERREO FIELD OF STUDY University of Osaka, Japan Medical Schoo Ph.D: 1990 Cancer Genelics University ol Hokkaido , Japan Molecular Biobgy B.A; 1982 RESEARCH AND PROFESSIONAL EXPERIENCE: Conclud nJ with prosont posiilan, Fst, chronokolcal arder, Prev ous amployment exparience, honors Kev personnel inclde the princIpal investgalor and any Olhor indivduals who partcipate  the scienul < develpmnt AiEculon tte project Key parsonnel typically will include all individua $ With doctoral other prolesskral Cegreos.but Aeoad prolects will include individuals - the mastors paccalu oaio lovel provided thoy contribute subslanbvu way Ihe sclarliic dovelopmanl 0 execution tho project Include present monborship on any Federal Governmont Pube advisory commitlee. Lisl, in chronobgical order; the tiiles, ali aulhors, and complete re"eroncos publications during the Pust Ihioo Y0ars raprasunlabve eat Br publicallon paninent Io Ihis apollcation: DO NOT EXCEED TWO PAGES: PRQEESSIONAL_EXPERIENCE 1982-1984 Researcher; Basic Research Labs Central Research Labs; Ajinomolo Co. Japan 1984-1988 Research Fellow, Dept. ol Molecular Genelics, Inst  of Molecular and Cellular Bio Osaka Univ , Japan 1988-1989 visiting Scientist, Center for Cancer Research Massachusetls Institule of Technolgy, MA 1989-1992 Assocale Scienlilic Stall , Dept, ot Biochemisiry, Cancer Institule Tokyo, Japan 1992-presenl Research Associate, La Jolla Cancer Research Foundation; La Jolla CA (lab 0l Dr. J.C. Reed) PUBLICATIQNS Sato, T,, el al, (1992). The human prohibitin gene located on chromosome 17921 is mulaled sporadic breast cancer. Cancer Res ,52 , 1643-1646 Takila Sato, et al, (1992). Correlation loss ol alleles on Ihe shor arms of chromosome 11 and 17 with metasiasis ol prmary breast cancer; Cancer Res , 52, 3914-3917 Sato et al, (1991). Accumulation of genelic allerations and progression primary breast cancer. Cancer Res 5794-5799 Sato et al, (1991). Alleltype ol human ovaran cancer. Cancer Res;, 51, 5118-5122. Sato et al, (1990). Allelotype of breast cancer: Cumulative allele lsses promole lumor progression in primary breast cancer. Cancer Res. 50, 7184-7189 Yamakawa K , Takahashi; E Sailo H,, Sato et al, (1991). Isolation and mapping 0l 75 new DNA markers on human chromosome Genomics; 9. 536-543_ Sato et al, (1989). The contormation ol malure a-amylase conditions ils secretion Irom yeast. Gene, 83,355 365 Izumolo Sato, et al, (1987). Expression of human pancrealic secrelory Irypsin inhibilor (PSTI) in SaccharQmvces cerevisiae Gene, 59, 151-159 Morinaga Y,, Takagi; H: Ishida Miwa, K, Salo, T. et al, (1987).   Threonine produclion by co-exislence of cloned gones coding homoserine dehydrogenase and homoserne kinase in Brexibacterium laclolermenlud Agric. Biol. Chem , 51 93-100 . Sato et al, (1987). New approach ol the high-level expression human IL-? cDNA in Ecoli J. Biochem: _ 101, 525-534. Taniguchi, T,, Fujita Hatakeyama Mori, H: Malsui; H; Salo el al, (1986). Interleukin 2 and its receplor: slructure and Iunctional expression of the genes Cold Sprig Harbor Symposia on Quantalive Biology; LL, 577- 586 Nakamura, Y. Salo et al, (1986). Expression of human salivary a-amylase gene in Saccharomyces crevisiae and Ils secrelion using Ihe mammalian signa sequence . Gene, 50,239-245_ Sato, et al, (1986) Expression Ihe human salivary   a-amylase gene in yeast and characterization ot Ihe secreted protein: Gene, 50 247-257 . PHS 398 (Rev: 9,91) (Form Page , Pege Njmbar p33as conenautvey 8: Ihe botlom broughout Ihe Aaplcain nollse AL tlixes *ua$ Ja, 30.