INBIFO Institut tur biologische Forschung_ Koln 6055 DBA /PWE UROBDIVBI Lymphocytes and Peripheral Blood and Frequencies SCE 21-Days Sidestream Exposed Macrophages Rat$ Pulmonary smeke cigarette Hackenberg R.-A. Walk Bachmayer and dif- exposed head-only rats were male Sprague Dawley Adul iculate 130 total par (60 and microgr ams ferent concentrations cigarette on 21 consecutive smoke sidestream (s5) matter/liter) local investigate systemi and geno- daily days for hours after the last daily hours ffects 55 rats toxi lymphocytes macrophages vere and pulmonary inhalation blood vitro analyses CA  frequencies (SCE SCE and sampled for milligram/kilogram Cyclophosphamide treatment metaphase) per ignificantly posit ive evoked statistically control) body weight 29 .9 + 1.2 , in  Lymphocytes (SCE : frequencies elevated SCE and compared sham- 0.020 _ rats) 0 . 214 rats CA: Ci: (SCE : rats, negat ive control rats exposed SCE influenced neither rats) . exposure 069 008 , (cells pulmonary macrophages in lymphocytes frequencies nor statistical significant crend pooled) lavaged from rats signi ficance biological Vas frequencies with unknown elevated SCE Erol: 5 . 9 0 .3 , low exposure (negat ive con observed after smoke 0 . 7 8 . 5 espectivelY concentrations: 8 .1 + and and high macrophages was frequency Pulmonary pools) . The affected smoke exposure not 1
INBIFO Institut tur biologische Forschung_ Koln DBA /PWE UROBDIVBI 6055 Peripheral Blood Lymphocytes and Rat$ Exposed 21-Days Sidestream SCE and Frequencies Pulmonary Macrophages cigarette smeke Hackenberg Bachmayer R.-A. Walk and rats were exposed head-only dif- Adul male Sprague Dawley (60 and 130 microgr ams total par iculate ferent concentrations sidestream (s5) cigarette smoke on 21 consecutive matter/liter) hours daily investigate systemi and local days for geno- ffects 55 rats hours after the last daily toxi inhalation blood lymphocytes and pulmonary macrophages vere sampled for vitro analyses SCE and CA  frequencies (SCE Cyclophosphamide treatment milligram/kilogram per metaphase) body weight posit ive control) evoked statistically ignificantly elevated SCE and frequencies in  Lymphocytes (SCE : 29 .9 + 1.2 , CA: 0 . 214 0.020 _ rats) compared sham- rats negat ive control rats (SCE : rats, Ci: exposed rats) . exposure influenced neither SCE 069 008 , in lymphocytes pulmonary macrophages (cells nor frequencies from rats pooled) statistical significant crend lavaged elevated SCE frequencies with unknown biological signi ficance Vas observed after smoke exposure (negat ive con Erol: 5 . 9 0 .3 , low and high concentrations: 8 .1 + 0 . 7 and 8 . 5 espectivelY pools) . The frequency Pulmonary macrophages was not affected smoke exposure 1