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METABOLITES LRACHIDOKIC OryGrhATED FROSTAGLAKDIKS ELAboratdrt Chy THERHOSPMY MPLC-HS Yegeel , HHoraag (Gb U1ac e {lephoor jc-716 Lulldin DOCOSAIEXAENOIC ACID Ahuc Alcchof4n2 , Acohol Nac[orai Inat(cute Studie 70205 Eetheada cflecte [nclud[n WteretLo phyblolosteal duceh variecy Ethinol he Bctabollu unaaturalea FaLET INTRODUCTIOW: ~Ptopete[ee 4teralion and ocher oiyeenated phyaical Proatariarding Etobtane Tthinol ~produetton Lddon clarifting Eenari"a necla eonruna Incona(aecne abortori hann nrachldon] ( Aachidonlc Nfrabolia Acchollan doeouaheraenole Koar cthanol Manatrd eetabolltee brale Tarina Hieceata Jnteettratione 1e[nopho "pholtelda [at e7 (rout Lonneenae polyunt aru0ad EEthydroxylated Jatt} C22:8 Mellan [anue corvefa[on obaervtd producl keueti naa deacr [bed . Coiyr[c ethanol ciar In Dorcal actabolitt Lnctr ceyeemated Hnavle collen, follout EEThOJS: anote c1nde separat [on C-HS Eeducing LAAA Iyptzmly ntolved [nal anilyal Ghould UarecEo {parafion" , derivitizacion MPLC-KS' aralyele fellotee KPLC-AS eleri4ca 2i: Incteoipea} CDME cow7oun-0 Y4le FLD-400-2 sladrural Jnvcel(RAliot roupled EtcdcZbol COCSEE ~Houat07 Corporation. Wludlea doconaheraenofc #cadid : Eupetrace #pec[rostte Mttonckenae  Czz :6 atty benEene eEhil htmn ane ethanol Ancubal(nk cartf[dge $ Eobile enar Wepatact Spcc : nnon(un acetele #aeple {Peade echie Rere[ 4t coeponcoce uidt? B"patace cecodictit canablan Pro:[a6l40d opEialted 230*c Wractioo- Standard EcuEce [gepetacuret Ineetiace 110-510 Aeac rcndllion Tecoided L4at #pectt# PaT[ [ ehto Ktapaic Eepatulio itandard LrunE could Blatnzulaed RESLLIS DISCUSSIOR; prcateglandioa thich Itnty doalnated Gntctra atandarda FicaipcTon chronatortaca (Figurg [)~ loaara Ind[vdunl nattiated olecule #eron{4tcd 61vte lacledinl rukeltirne Tocie 8742rl Jenale molecule cotlut[nr peala Aebonietre Jaldae nuabr( Jceeatt {ractiong Peale Ta erny Walued (inrt Icancaror Jcllctln Arachldooic cuntrol locubation hydrory hoiled abserdeo CnlioCu Rroupt acetale raction? IPretTA Indlcated che 0404 anotrdron Exaeination Lalo Tulared Foratlen elucint eonohydrorzluted Ceat rruTER uhlch qa4logoul peakl 7ue Eeer thelr IPrecie Ecrbolite attaballtea Rat EIOUP [M+4-Kzo] ~conpounde 40417ed. Itaedurd 4aleroua Vich utendar coupletely #Pectte nzleboue uhich Vent ectabolicee ~corfeepond pctiUce tr[hydrozylated aatuned linse e[ant Arin fore Ficepl[on Cahyator uetaboafite Pob [b(iity Joula correapond eecabolite haueyer CATEI Aenened Ilbely 'Ozyrcnated Watt obacrved Fuceedelol} den0x spec E robetty elucioob Aeard cohcLuSiONS PLcteneaa UaeLo Geld dcr [ValIvce JrenaEed 46 Mute variecy petia ranke donloart cenelcivity Jtandard compound# Tne #pecer" Weple loreel hydroxylated derIvat (vee and mfrlated Foleculer obtened Jocrludin? Jeonialed noleculea Yrte @pecte0 Prolonted Iolecule olecule I5a Tontird Aemon[4022 Foctby (#aaf Eed Beedlct Woccede[UfI) APPled intont(ty. Poteibly cecholque docoutba Vetiut Lrcpalacion . nuebrr nove ~oxyzenated Gettbolthe t Oeneoepray Identfficatton dlacovered Lana {ema([Y Aeeabolcea Jete C12a6 Jnct tEt df [oct Rroupi conobydrorylated Ctpr45 llotarae ARat ~nvelope rachidonfc Acid Hater elulloz lour ronohydroxya Turteur cboue coapletely a80[gned . cocplecely aniloroue yhieh ceula Produced Cbecira Ecenbollret revea led P648a ablien [denciteee Probtede 3 8 0