(1982) 139-146 Muluon Racunch Elec 7er Bicmedicl Sister-chromatid exchange (SCE) analysis in mothers exposed to DNA-damaging agents and their newborn infants Ram Seshadri Elizabeth Baker and Grant R. Sutherland Unil Hacmalolony, Flindars Madical Cantre; Brdford Park; 5.A. 504} und Cytogeretia Urourimeni Hospilal, North Adalaide 5,4, S6T (Aurtralie) Adelulde Caildren" (Reccived 1981) (Revision rccrived [980) AugWL (Acopted 1981) ALuJI Summary SCE in the lymphocytes of mothers and their newbom infants The incidence detailed antenatal history ol parental habits such as smoking determined_ alcohol consumption and possible exposure to DNA-damaging agents docl mented The results showed that the SCE rate in the ncwbomn is significantly Iess tban   that  of their mothers: Mothers who consumed alcohol, but not cigarette signilicantly increased SCE ratc compared smokers, bad control  mothers. However, these  materal habits did allect thc SCE rate thcur  inlants: Neonales neural   lube delects  showed significantly  increased SCE rate wl compared babies: nOFIn? Sister-chromatid exchange (SCE) represents the reciprocal interchange of DNA between chromatids at apparently homologous loci. Although the precise naturc and the formation of SCE are mechanism involved SCE analysis has unknown comc sensitive means of detecting DNA damage. SCE analysis has bccn Into uUsc drugs , shown be useful for asscssing the affect upon DNA o cytotoxic (Peny and Evans, 1975; Nakanishi and Schncider, 1979) , viruscs (Kurvink ct al,, 1978) and pollutants 1978). entronmental {ctoscen Tnan agents which damage DNA might result The exposure of the [elus birth al. (1979) showed SCE analysis scnsitive method delects Farhm CNar for Lhe deleclion of the mutagenic affects' of cyclophosphamide, mitomycin  and (emale mice and thcir (ctuscs; Funes-Cravioto et al. (1977) observed adriamycin Rennnt Icquert 0165.1161/32/00n-0000 /502.75 Ekevicr Riomedicl Prees 1
Muluon Racunch (1982) 139-146 Elec 7er Bicmedicl Sister-chromatid exchange (SCE) analysis in mothers exposed to DNA-damaging agents and their newborn infants Ram Seshadri Elizabeth Baker and Grant R. Sutherland Urourimeni Hacmalolony, Flindars Madical Cantre; Brdford Park; 5.A. 504} und Cytogeretia Unil Adelulde Caildren" Hospilal, North Adalaide 5,4, S6T (Aurtralie) (Reccived 1981) (Revision rccrived AugWL [980) (Acopted ALuJI 1981) Summary The incidence SCE in the lymphocytes of mothers and their newbom infants determined_ detailed antenatal history ol parental habits such as smoking alcohol consumption and possible exposure to DNA-damaging agents docl mented The results showed that the SCE rate in the ncwbomn is significantly Iess tban   that  of their mothers: Mothers who consumed alcohol, but not cigarette smokers, bad signilicantly increased SCE ratc compared control  mothers. However, these  materal habits did allect thc SCE rate thcur  inlants: Neonales wl neural   lube delects  showed significantly  increased SCE rate compared nOFIn? babies: Sister-chromatid exchange (SCE) represents the reciprocal interchange of DNA between chromatids at apparently homologous loci. Although the precise naturc and mechanism involved the formation of SCE are unknown SCE analysis has comc Into uUsc sensitive means of detecting DNA damage. SCE analysis has bccn shown be useful for asscssing the affect upon DNA o cytotoxic drugs , (Peny and Evans, 1975; Nakanishi and Schncider, 1979) , viruscs (Kurvink ct al,, 1978) and entronmental pollutants Tnan {ctoscen 1978). The exposure of the [elus agents which damage DNA might result birth delects CNar Farhm al. (1979) showed SCE analysis scnsitive method for Lhe deleclion of the mutagenic affects' of cyclophosphamide, mitomycin  and adriamycin (emale mice and thcir (ctuscs; Funes-Cravioto et al. (1977) observed Rennnt Icquert 0165.1161/32/00n-0000 /502.75 Ekevicr Riomedicl Prees 1