Biographical Sketch Chrislopher U.T. HELLEN Christopher U.T. HELLEN EDUCATION Dcpartment Biochemistry, University of Manchester , BSc: (1983) Manchester, United Kingdon College - Scicnces PhD. (1988) Linacre and Dept: ol Plant University of Oxford and NERC Institute of Virology, Oxford, United Kingdom EMPLOYMENT Virology, Mansfield Road, Oxford, 1984-1987 NERC Institute of United Kingdom 1987 1994 Postdoctoral Rcscarch Associate Microbiology, SUNY at Stony Brvok; Stony Brook Dcpartment NY 11794-8621, USA 1944 Restarch Assistant Professor , present Microbiology and Immunology, SUNY Hcalth Scicnce Center at Brooklyn; Dcpartmcnt of Brooklyn; NY 11203 HONOURS Natural Environmcnt Rescarch Council (UK) Graduate Fellowhip 1984-1987 Visiling Scientist Fellowhip Royal Nclhcrlands Government 1986 Ncw York State Facully Development Award 1995 PUBLICATIONS CU:T: Hellen; GW. Witherell and E; Wimnmer; 1990. Cap-independent Jang; $.K, T,V Testova translation of picornavirus RNAs: slruclure aud function of the internal ribosomal entry sitc: Enzyme 44: 292-309 Wimmer. 1991. Site-directed mutagenesis of the putative Hammerle; T, CUT: Hellen, and catalytic triad of poliovirus 3C proleinasc: Journal of Biological Chemistry, 266: 5412-5416 Cooper. 1991, Synthesis and protcolytic processing of arabis mosaic ncpovirus, Hcllen,, CUTand cherry Ical roll nepovirus and strawbrry latent ringspot nepovirus proleins in reticulocyte Lysate: Archivcs %f Virology: 120: 19-31 Coopcr, M:-L Liu, YY: Edwards and CU.T Hellen. 1991_ satellite RNA of arabis mosaic nepovirus and ils pathological impact: Annals of Applied  Biology: 118; 577-587. H.G Krausslich, -K Lee and Facke; Hellen, CUT, Wimmer. 1991 Characterizalion of poliovirus 2A proteinasc by mulational analysis: residues required for aulocatalytic activity are csscnlial for the induction of cleavage of eukaryotic initiation factor 4F polypeptide p22O. Joutrnal of Virology 65: 4226 4231_ poliovirus RNA Pcstova Tv CUT Hellen, and E, Wimmer. 1991. Translation the essential rolc of cis-acting oligopyrimidine element within thc nontranslated region and the involvement of trans- acting cellular 57 KDa protein_ Virology lonrvial 0f 65: 6194-6204, Hellen, CUTand Wimmcr; 1992. The role of prolcolytic processing in thc morphogenesis of vinus particles Exprricntia  48: 201-215. 5067951
Biographical Sketch Chrislopher U.T. HELLEN Christopher U.T. HELLEN EDUCATION BSc: (1983) Dcpartment Biochemistry, University of Manchester , Manchester, United Kingdon PhD. (1988) Linacre College - and Dept: ol Plant Scicnces University of Oxford and NERC Institute of Virology, Oxford, United Kingdom EMPLOYMENT 1984-1987 NERC Institute of  Virology, Mansfield Road, Oxford, United Kingdom 1987 1994 Postdoctoral Rcscarch Associate Dcpartment Microbiology, SUNY at Stony Brvok; Stony Brook NY 11794-8621, USA 1944 present Restarch Assistant Professor , Dcpartmcnt of Microbiology and Immunology, SUNY Hcalth Scicnce Center at Brooklyn; Brooklyn; NY 11203 HONOURS Natural Environmcnt Rescarch Council (UK) Royal Nclhcrlands Government Ncw York State Graduate Fellowhip Visiling Scientist Fellowhip Facully Development Award 1984-1987 1986 1995 PUBLICATIONS Jang; $.K, T,V Testova CU:T: Hellen; GW. Witherell and E; Wimnmer; 1990. Cap-independent translation of picornavirus RNAs: slruclure aud function of the internal ribosomal entry sitc: Enzyme 44: 292-309 Hammerle; T, CUT: Hellen, and Wimmer. 1991. Site-directed mutagenesis of the putative catalytic triad of poliovirus 3C proleinasc: Journal of Biological Chemistry, 266: 5412-5416 Hcllen,, CUTand Cooper. 1991, Synthesis and protcolytic processing of arabis mosaic ncpovirus, cherry Ical roll nepovirus and strawbrry latent ringspot nepovirus proleins in reticulocyte Lysate: Archivcs %f Virology: 120: 19-31 Liu, YY: Coopcr, M:-L Edwards and CU.T Hellen. 1991_ satellite RNA of arabis mosaic nepovirus and ils pathological impact: Annals of Applied  Biology: 118; 577-587. Hellen, CUT, Facke; H.G Krausslich, -K Lee and Wimmer. 1991 Characterizalion of poliovirus 2A proteinasc by mulational analysis: residues required for aulocatalytic activity are csscnlial for the induction of cleavage of eukaryotic initiation factor 4F polypeptide p22O. Joutrnal of Virology 65: 4226 4231_ Pcstova Tv CUT Hellen, and E, Wimmer. 1991. Translation poliovirus RNA the essential rolc of cis-acting oligopyrimidine element within thc nontranslated region and the involvement of trans- acting cellular 57 KDa protein_ lonrvial 0f Virology 65: 6194-6204, Hellen, CUTand Wimmcr; 1992. The role of prolcolytic processing in thc morphogenesis of vinus particles Exprricntia  48: 201-215. 5067951