Dicemcoicu Yc 23 Internalicnal ! pidem olog c3l Associalion 1994 Panlec Gueat Budlain Childhood and Adolescent Passive Smoking and the Risk of Female Lung Cancer FU-LIN WANG EDGAR JOHN LOVE, NING LIU' AND XU-DONG DAI' Wang F.L (Depattineni Cormunity Heallh Scierces Medicine; University 0l Calgary, 3330 Hospilal Dc, Facully NW, Calgary. Alberta, TZN ANI) Love EJ; Liu Canada and Dai Xd Childhood and adolescent passive smoking {ung and emalc International Joumal cl Epidemiology 1994; 23: 223-230. cancci Background studies have reported Ihe rclationship between passive sroking (PS} FGk early Iife and the nsk of cancer This study was done Dvalat lhe nsk, Tcmale lung PS,especially Ihat during childhood cancer Iram dolescence Using household exposure Melnods lobacco smoke as @sumnalle pallco case-ccnlrol suoi Harbin China. We inicrvlewed conqucieo 114lemale cance lung Orimany aged 3069 years. and their casts hospiial-based conlrols_ The controls were non-cance palients selected Irom Ihe same hospital as the cases, and malched cn age (+ years). rcsidental smoking sialus over their Illelime Ted ano There ere 59 Qathe 'ovoeveg Xho Ruc smoked and 55 pairs Informalion on PS was collected by resicence for never smoreo each Peric-s: 0-6 14,15-22,23-30 ard 31-69 years Household PS signilicanlly increases inhe nsk temale lung cancer lor those exposed at ages 22 cunder The risk was also increased for Ihose non-sinoking pai-s wno nave smored Khen exposed unde the age 0f 15 veams FiDosic ages 14 rnaleina smokino younger increased the risk by 170% (odcs ratio, OR 2.7, aqui Gence 9590 conl [CI]: 88}. but not paterna nicna 49 4 (OR 1.40, 95%6Ci: 0.92 sinokino The 501. ris k was highes: (or thosc exposeq underike age seven (OR 3,46, 95rCi; 80 6.65) ard was also signilicani at ages 7-14 (OR 108. 9586ci; 1.62 57)and 45-22 (OR 3,10,95*Cl: 1.52-6.31) years Under the age years, Ihe OR PS(P < 0.0D1) Olnote incicased "namaunol ORinall five lornon-smoking exposure penods pairs Kere similar ID Ihose lor all 114 pairs sludied: Conclusions Househoid' PS; pariculary childhood, thal during Ine risk lung Inciessec Tne lemale Cancer PS should be done by diterent periods assersmen xposuie increasing evidence Suggesting that involumary Thete especially that during childhood. Data were collecicd in passive smoking (PS) increases the risk of lung the city o Harbin the People' Republic China findings However, thc have nOI during 1985 been consistent 1987. #th resprct who are 1[ higher risk:adults or children. Some studies have noted the importance of exposure t0 MATERIALS AND METHODS lobacco smoke in early life in relation cancer Ns% In The cases were female primaty lung cancer palienis who adulhood while Tound olnrts associalion for were Selecicd fTom the Harbin Cancer Rcgistry. The noking women exposed smoke during [obacro critera for inclusion - Resident of Harbin city Wcrc #Bed childhood 30 69 ycats and diagnosed by hisiopathology duting In addition the methods eslimate PS varied by January [985 and Vovember |986 tolal of 11 cascs study The estimate of PS frorn only the husband or the eligible and alllwere inierviewed Wcrc face-Io-facc. They which has snous M often bten used included 5$ adenocatcinoma qucston ccll carci- This study Jyuamous using hous-hold exposure t0 tobacco smoke 20 small ccll and oat cell n1oma and other carcinoMz eslimale of PS auemplcd clarily further the Iypes. teporiing sslcm relationship belween #45 Sci up (0 ensurc quick Tcmale lung cancer and PS [egIstralion 0. cases and umcdiale invesiigalion The coniro 4uhoul 4cnt Datc cancer, trom 1d missions t0 he sane hospital Drpariicni o thc cases and matched Connututy sotncs Hcalth of Mcdicing Facui age (+ smoking Ca ycars), re Sidenlial arca an 3sity Hosrital Dr | Nw. Csgaty 4174 Satue Caada TrN ANI. lifetime (whether Orcr cuftent ex-Sioker). Drjunmen Eridemolozy. Hcilonging Iastitute Ior Cancct Infornation 0n sX age,residentialarea andthe diagno Matbu, Ratch Rapublic of China Tie rconlc . obtained from ile patient file and the preliminary 223
Dicemcoicu Yc 23 Panlec Gueat Budlain Internalicnal ! pidem olog c3l Associalion 1994 Childhood and Adolescent Passive Smoking and the Risk of Female Lung Cancer FU-LIN WANG EDGAR JOHN LOVE, NING LIU' AND XU-DONG DAI' Wang F.L (Depattineni Cormunity Heallh Scierces Facully Medicine; University 0l Calgary, 3330 Hospilal Dc, NW, Calgary. Alberta, Canada TZN ANI) Love EJ; Liu and emalc and Dai Xd Childhood and adolescent passive smoking {ung cancci International Joumal cl Background Epidemiology 1994; 23: 223-230. FGk studies have reported Ihe rclationship between passive sroking (PS} cancer This study was early Iife and the nsk of done Dvalat lhe nsk, Tcmale lung cancer Iram dolescence PS,especially Ihat during childhood Melnods Using household exposure lobacco smoke as @sumnalle pallco case-ccnlrol suoi conqucieo Harbin China. We inicrvlewed 114lemale Orimany lung cance hospiial-based casts conlrols_ The controls aged 3069 years. and their were non-cance palients selected Irom Ihe same hospital as the cases, and malched cn age (+ years). rcsidental Ted ano smoking sialus over their Illelime smoked and 55 pairs There ere 59 Xho Ruc never smoreo Informalion on PS was collected by resicence for Qathe 'ovoeveg Peric-s: 0-6 each 14,15-22,23-30 ard 31-69 years Household PS signilicanlly increases inhe nsk temale lung cancer lor those exposed at ages 22 wno nave smored cunder The risk was also increased for Ihose non-sinoking pai-s veams FiDosic Khen exposed unde rnaleina smokino the age 0f 15 ages 14 younger increased the risk by aqui 9590 conl Gence nicna 49 4 170% (odcs ratio, OR 2.7, [CI]: 88}. but not paterna sinokino (OR 1.40, 95%6Ci: 0.92 highes: (or thosc exposeq underike 501. The ris k was age seven (OR 3,46, 95rCi; (OR 108. 9586ci; 1.62 80 6.65) ard was also signilicani at ages 7-14 57)and 45-22 (OR 3,10,95*Cl: 1.52-6.31) years incicased "namaunol Under the PS(P < 0.0D1) Olnote age years, Ihe OR ORinall five exposure penods lornon-smoking ID Ihose lor all 114 pairs sludied: pairs Kere similar Conclusions Househoid' PS; pariculary thal during childhood, Inciessec assersmen Ine risk lemale lung PS should be done by diterent periods Cancer Tne xposuie Thete increasing evidence Suggesting that involumary especially that during childhood. Data were collecicd in passive smoking (PS) increases the risk of lung the city o Harbin the People' Republic However, thc China findings have nOI been consistent during 1985 1987. #th resprct who are 1[ higher risk:adults or children. Some studies have noted the importance of exposure t0 MATERIALS AND METHODS lobacco smoke in early life in relation cancer Ns% In adulhood The cases were female primaty lung cancer while olnrts palienis who Tound associalion for were Selecicd fTom the Harbin Cancer Rcgistry. The noking women exposed [obacro smoke during critera for inclusion - childhood Wcrc Resident of Harbin city #Bed 30 69 ycats and diagnosed by hisiopathology In addition duting the methods eslimate PS varied by January [985 and Vovember |986 tolal of 11 study The estimate of PS frorn only the husband or the cascs Wcrc snous M eligible and alllwere inierviewed which has face-Io-facc. They often bten used qucston This study included 5$ adenocatcinoma using Jyuamous ccll carci- hous-hold exposure t0 tobacco smoke n1oma 20 small ccll and oat cell eslimale of PS carcinoMz and other auemplcd clarily further the relationship belween Iypes. teporiing sslcm Tcmale #45 Sci up (0 ensurc quick lung cancer and PS [egIstralion 0. cases and umcdiale invesiigalion The coniro 4cnt Datc 4uhoul cancer, trom 1d Drpariicni o Connututy missions t0 he sane hospital Hcalth  sotncs Facui of Mcdicing thc cases and matched 3sity Ca Hosrital Dr Nw. Csgaty 4174 Caada age (+ ycars), re Sidenlial arca an smoking Satue TrN ANI. Orcr lifetime (whether cuftent ex-Sioker). Drjunmen Eridemolozy. Hcilonging Iastitute Ior Cancct Ratch Infornation 0n sX Matbu, age,residentialarea andthe  Tie rconlc . Rapublic of China diagno obtained from ile patient file and the preliminary 223 |