SPONSOR: InITIATIOn DATE: 1-21-83 Lcrillard COPLETIUX DATE: 3-07-83 ISSUE   DATE: MATERIAL: A-44 IND[NG Study   In SUBJECT: RANGE ALBINO Rats WITH 4-44: PHASES AND roject No. 1488( 1 } Borri con IMAL REPORT SUHHARY range-finding study conducted determine che estinated maxinum was dose (MTD) Ievel for test  material, A-44_ Based tne resuits tolerated che this study , the A-44 is 3750 ng/kg for estimated maxinum tolerated dose ma le ard  1750 mg/kg for female rats. TEST ARTICLE The test article, A-44 clear Tiquid and was received {rom the 19 , 1982 and  January sponsor in amber slass vial on "Noverber 28 , 1983 The article cest Kas stored under refrigeration che container which it was MethyIcellulose (13) the  vehicle rece ved . was used this study. Stability information is retained the sponsor _ TEST ANIMALS Eight ma le eight female Sprague-Daw ley aIbino and rats, purchased {rom Charles River Breeding Laboratories (Wilmington, Massachusetts selected were for Prior rantined J this study . Placenent scudy, che anima Is for rere cua least and observed daily for The seven aay 5 appearance and benavior animaIs were individua housed in stainless suspended steel cages with wire nesh bottoms Purina Rodent Laboratory cnow & "5001 and water ava i lable Here ad lbitun_ che end  of the quarantine od , heaitny animaIs peri between 169 192 for 149 165 and males and and for fema were a55 - gned
SPONSOR: InITIATIOn DATE: 1-21-83 COPLETIUX DATE: 3-07-83 ISSUE   DATE: Lcrillard MATERIAL: A-44 RANGE IND[NG Study   In ALBINO Rats WITH 4-44: PHASES Borri con roject No. 1488( 1 } IMAL REPORT SUBJECT: AND SUHHARY range-finding study was conducted determine che estinated maxinum tolerated dose (MTD) Ievel for che test  material, A-44_ Based tne resuits this study , the estimated maxinum tolerated dose A-44 is 3750 ng/kg for ma le ard  1750 mg/kg for female rats. TEST ARTICLE The test article, A-44 clear Tiquid and was received {rom the sponsor in amber slass vial on "Noverber 19 , 1982 and  January 28 , 1983 The cest article Kas stored under refrigeration che container which it was rece ved . MethyIcellulose (13) was used the  vehicle this study. Stability information is retained the sponsor _ TEST ANIMALS Eight ma le and eight female Sprague-Daw ley aIbino rats, purchased {rom Charles River Breeding Laboratories (Wilmington, Massachusetts were selected for this study . Prior Placenent scudy, che anima Is rere cua rantined for least seven aay 5 and observed daily for appearance and benavior The animaIs J were individua housed in suspended stainless steel cages with wire nesh bottoms Purina Rodent Laboratory cnow & "5001 and water Here ava i lable ad lbitun_ che end  of the quarantine peri od , heaitny animaIs between 169 and 192 for males and 149 and 165 for fema were a55 - gned