1990: J(.3-13 Smarinc Reaieo D; TOBACCO RELATED DISEASES* R. Peto K. Wheatley R: Gray R. Doll ICRF Cancer Studies Unit, Radcliffe Infirmary, Oxford, Abstract reviewed. association between smoking and human pathology The historical terms Of the tnree main types discussed The evidence for such an association disease and respiratory disease cancer; Vascular lated smoking ol disease established relationshios are also covered briefly as well a5 diseases Jcss Other, reduced in incidence among smokers Key words: Cancer, vascular disease, respiratory disease Introduction nowever, the effect was thought t0 ce When, shortly after the end of the Secona the result of thermal trauma Irom  tne World War, reasons began t0 DE sougnt stems of pipes and the only diseases that the mortality attributed ior the increase tobacco attrbuted cirectyy most were lung cancer IhaI was Occurring English language medical texis worlo; (here was. ceveloped attacks of tobacco angina (that possible Jess awareness of the ene anytning angina brcught on DY smoking; wnich are smoking than there nad peen efiects ambiyopia and tooacco For tne spread of tre certainiy 50 years pariier produced Dy   heavy (that plindness wnich was 35 entrenchec nazit, aigoreate nale probaoly smcking; wnich aiso rare health among woikcrs amona combination with severe anly nad so occums of the population; mjie Talnuttitioni culled the co lective sense that the Doss- tobacco being the Culprit was bility of shoula navc Thal little auteniion possible only atiention etiecis been zaid tre scant Gien not really surcrising cancer 0m smoking That smoking might cause For alihough tobacco had at leas: as Tay novv szem been recocnised [ne Iip nad use for Cver J00 vears; been eariy as 1795, wnen Sommering zointeo | snuff, chewved Mos:  zeen used Carciroma 0f tne lip mmost out tna: very Iitile haa heen smokec pipes obacco peowver " Clgec partouascy Treclent Jnem cigarettes and {ne other ways smokec Iowver hip pipes. [cbacco nad been used were Wnica coT  - atfacked DY Carcinoma >ecause hazardous because smcke mucn anc tne teet7 aresser ey thevaeer 'hal? O8 a nineteentn had Morcover not innaled_ Cigarettes; the beginning of cecome common Cny exoerienced surgeons De- century Many tre {ventieth century. and two Of [neir cause lleved tnat snoking mignt also main effects took many years tO prcduce: the tongue [1]. In both cases cancer Wond Heauth Tcbacco RCin% under (he jusoices tte First EurDocan (ontcrence #Pidar Oclerted Aociawon ~ovemde Oxz 6hE. Dol, ICRF Cancer Slud es Unut, Rodchffe infrmary; CCT A Rrcnaro Addr2r5 Conesdordence
Smarinc Reaieo D; 1990: J(.3-13 TOBACCO RELATED DISEASES* R. Doll R: Gray R. Peto K. Wheatley ICRF Cancer Studies Unit, Radcliffe Infirmary, Oxford, Abstract association between smoking and human pathology reviewed. The historical The evidence for such an association discussed terms Of the tnree main types lated smoking cancer; Vascular disease and respiratory disease ol disease Other, Jcss established relationshios are also covered briefly as well a5 diseases reduced in incidence among smokers Key words: Cancer, vascular disease, respiratory disease Introduction When, shortly after the end of the Secona nowever, the effect was thought t0 ce World War, reasons began t0 DE sougnt the result of thermal trauma Irom  tne the mortality attributed stems of pipes and the only diseases that ior the increase most were attrbuted cirectyy tobacco lung cancer IhaI was Occurring worlo; (here was. medical texis English language ceveloped possible ene tobacco angina (that attacks of anytning Jess awareness of the efiects smoking than there nad peen angina brcught on DY smoking; wnich are For tne spread of tre certainiy and tooacco ambiyopia 50 years pariier nazit, wnich was 35 entrenchec (that plindness produced Dy   heavy aigoreate nale woikcrs among smcking; wnich aiso rare probaoly amona health mjie nad so occums anly combination with severe of the population; culled the co lective sense that the Doss- Talnuttitioni bility of tobacco being the Culprit was Thal little auteniion shoula navc Gien only scant atiention been zaid tre possible etiecis That smoking might cause cancer 0m smoking not really surcrising at leas: as Tay novv szem For alihough tobacco had [ne Iip been recocnised been use for Cver J00 vears; nad eariy as 1795, wnen Sommering zointeo Carciroma 0f tne lip mmost Mos:  zeen used snuff, chewved out tna: obacco smokec pipes very Iitile haa heen Treclent Jnem peowver " Clgec partouascy smokec cigarettes and {ne other ways pipes. Iowver hip Wnica [cbacco nad been used were atfacked DY Carcinoma >ecause coT  - anc tne teet7 mucn hazardous because smcke aresser ey thevaeer 'hal? O8 a nineteentn not innaled_ Cigarettes; Morcover had century Many exoerienced surgeons De- cecome common Cny the beginning of lleved tnat snoking mignt also cause tre {ventieth century. and two Of [neir main effects took many years tO prcduce: cancer the tongue [1]. In both cases Tcbacco RCin% under (he jusoices Wond Heauth #Pidar Oclerted tte First EurDocan (ontcrence Aociawon ~ovemde Dol, ICRF Cancer Slud es Unut, Rodchffe infrmary; CCT Oxz 6hE. Addr2r5 Conesdordence A Rrcnaro |