CONSULTANTS, INC BIO-RESEARCH ConsiiATiON ReseArch evilopalni WENUE Conuricial Komiurgar Direclor MSSACHUSETTS Cicaringe 0241 3ER~Filo Diruciar Rcjanrc] (6i7) 864 8/45 1975 June 26, D:  Carpenter, Senior Scientist Mr . Philip Morris, U.S.A_ Box 26583 2326 1 Virginia Richmlond, Dear Bob: The present letter constitute s reporl on short-terrn our acute toxicity of smoke from three types of cigarette& tudy on the R & D 213 and Kentucky reference 1RL control i.e. R & D 207, C187/R6_ This short study carrie$ our project No. Several logous studies on acute toxicity of cigarette smoke were ana Performed by us No. Previously, the most recent one was our C187/R5 reported on by letter dated February 13, 1975. thodology used in the present project was identical The me espe cially for C187/RS . We again to tbat described previously, used CAFI/IJ female mice; weights ranged from 16 _ their body their age ranged to 23.5 of the experiment, and gram at the time Care {rom approximately 10 to 40 weeks. was takcn that the age distribution and the body weight distribution of thbe expe r - of each imental animals was approximately the same for the study 1 of the three types of cigarette s. The Table It is Glearly evidlent results are shown that smoke from both types 207 and 213 cigarettes is considerably less toxic than that of [R Kentucky reference control cigarettes; highly significant by statistical criteria these differences are with 83 and 5_ confidence le vel far below 1% (t values 0[ 5 98, respectively).
BIO-RESEARCH CONSULTANTS, INC ConsiiATiON ReseArch evilopalni Conuricial WENUE Cicaringe MSSACHUSETTS 0241 (6i7) 864 8/45 Komiurgar Direclor 3ER~Filo Diruciar Rcjanrc] June 26, 1975 Mr . D:  Carpenter, Senior Scientist Philip Morris, U.S.A_ Box 26583 Richmlond, Virginia 2326 1 Dear Bob: The present letter constitute s our reporl on short-terrn tudy on the acute toxicity of smoke from three types of cigarette& i.e. R & D 207, R & D 213 and Kentucky reference 1RL control This short study carrie$ our project No. C187/R6_ Several ana logous studies on acute toxicity of cigarette smoke were Performed by us Previously, the most recent one was our No. C187/R5 reported on by letter dated February 13, 1975. The me thodology used in the present project was identical to tbat described previously, espe cially for C187/RS . We again used CAFI/IJ female mice; their body weights ranged from 16 _ to 23.5 gram at the time of the experiment, and their age ranged {rom approximately 10 to 40 weeks. Care was takcn that the age distribution and the body weight distribution of thbe expe r - imental animals was approximately the same for the study of each of the three types of cigarette s. The results are shown Table It is Glearly evidlent 1 that smoke from both types 207 and 213 cigarettes is considerably less toxic than that of [R Kentucky reference control cigarettes; these differences are highly significant by statistical criteria with confidence le vel far below 1% (t values 0[ 5 83 and 5_ 98, respectively).