  TooManyCells . Spatial . SummaryPlot 
    

 Collects functions pertaining to plotting the summary of statistics for all 
 samples . 

Gregory W. Schwartz

Collects functions pertaining to plotting the summary of statistics for all
samples.
-}

{-# LANGUAGE OverloadedStrings #-}
{-# LANGUAGE BangPatterns #-}
{-# LANGUAGE PackageImports #-}

module TooManyCells.Spatial.SummaryPlot
    ( plotSummary
    ) where

import Control.Exception (SomeException (..), try, evaluate)
import Control.Monad (when, mfilter, guard)
import Data.Bool (bool)
import Data.Function (on)
import Data.List (sortBy, groupBy, foldl', sort, maximumBy, zipWith4)
import Data.Maybe (fromMaybe, mapMaybe, isNothing)
import Ploterific.Plot.Plot (labelColorScale)
import Ploterific.Plot.Types (ColorLabel (..))
import Safe (headMay)
import System.Environment (getArgs)
import System.IO (hPutStrLn, stderr)
import TextShow (showt)
import qualified BirchBeer.Types as Birch
import qualified Control.Foldl as Fold
import qualified Control.Lens as L
import qualified Data.ByteString.Lazy.Char8 as BL
import qualified Data.ByteString.Char8 as B
import qualified Data.Csv.Streaming as CSVStream
import qualified Data.Csv as CSV
import qualified Data.Foldable as F
import qualified Data.Map.Strict as Map
import qualified Data.Sequence as Seq
import qualified Data.Set as Set
import qualified Data.Text as T
import qualified Data.Text.Read as T
import qualified Data.Vector.Unboxed as VU
import qualified Data.Vector as V
import qualified Graphics.Vega.VegaLite as VL
import qualified Graphics.Vega.VegaLite.Theme as VL
import qualified Statistics.Test.KruskalWallis as S
import qualified "statistics" Statistics.Quantile as S
import qualified "statistics" Statistics.Types as S
import qualified Filesystem.Path as FP
import qualified Turtle as TU

import qualified TooManyCells.File.Types as Too
import qualified TooManyCells.Spatial.Types as Too

-- | Get all pairwise comparisons.
pairwise :: (Eq a, Ord a) => [a] -> [[a]]
pairwise xs = Set.toList
            . Set.fromList
            . filter (\[x,y] -> x /= y)
            . fmap sort
            $ (\x y -> [x,y]) <$> xs <*> xs

  | Safer    test .
safeKWTest :: (VU.Unbox a, Ord a) => [VU.Vector a] -> IO Double
safeKWTest xs = do
  res <- try ( evaluate
             . maybe 1 (S.pValue . S.testSignificance)
             $ S.kruskalWallisTest xs
             ) :: IO (Either SomeException Double)
  res' <- case res of
            Left ex -> do
              hPutStrLn stderr $ "Caught exception, continuing with p = 1: " <> show ex
              return 1
            Right val -> return val
  return res'

-- | Add on the relevant p-values
pVal :: Birch.Feature
     -> [Map.Map T.Text T.Text]
     -> IO ([Map.Map T.Text T.Text], [Map.Map T.Text T.Text])
pVal (Birch.Feature feature) ms = do
  statRows' <- statRows
  statSummary' <- statSummary
  return (statRows', statSummary')
  where
    statRows = do
      tests' <- tests
      pairwiseTests' <- pairwiseTests
      return
        . mconcat
        . zipWith3
            (\ x xs ys
            -> fmap (\ m
                    -> foldl' (\acc (!a, !b) -> Map.insert a b acc) m (("kwPValue", x):xs)
                    )
            . concatMap Too.unLabelList
            . Too.unVarList
            $ ys
            )
            tests'
            (fmap Too.unVarList pairwiseTests')
        $ grouped
    statSummary = do
      tests' <- tests
      pairwiseTests' <- pairwiseTests
      return
        . mconcat
        . zipWith4
              (\ s x xs ys
              -> fmap (\ m
                      -> foldl'
                          (\acc (!a, !b) -> Map.insert a b acc)
                          m
                          (("highestLabels", s):("kwPValue", x):xs)
                      )
              . concatMap Too.unLabelList
              . Too.unVarList
              $ ys
              )
              highestLabels
              tests'
              (fmap Too.unVarList pairwiseTests')
          $ summarizedVarList
    highestLabels :: [T.Text]
    highestLabels = fmap ( T.intercalate "/"
                         . fmap showt
                         . sortBy ((flip compare) `on` fst)  -- Descending
                         . concatMap
                             ( fmap
                                 (\ !x
                                 -> ( maybe
                                       (error "No median found")
                                       (either error fst . T.double)
                                    $ Map.lookup "median" x
                                    , Map.findWithDefault
                                       (error "No label found")
                                       "statLabel"
                                       x
                                    )
                                 )
                                 . Too.unLabelList
                             )
                         . Too.unVarList
                         )
                  $ summarizedVarList
    summarizedVarList :: [Too.VarList (Too.LabelList (Map.Map T.Text T.Text))]
    summarizedVarList = Too.VarList
                      . fmap ( Too.LabelList
                             . (:[])
                             . getStatSummaries
                             . Too.unLabelList
                             )
                      . Too.unVarList
                    <$> grouped
    getStatSummaries !ms = Map.fromList
                         $ ("median", T.pack . show $ getMedianFromMaps ms)
                         : ("feature", feature)
                         : foldl'
                            (\ acc x
                            -> ( x
                               , fromMaybe "" $ Map.lookup x =<< headMay ms
                               )
                               : acc
                            )
                            []
                            ["statLabel", "Var1", "Var2"]
    getMedianFromMaps = S.median S.s . VU.fromList . fmap getFeature
    kruskalOrBust = fmap (T.pack . show) . safeKWTest
    tests :: IO [T.Text]
    tests = mapM ( kruskalOrBust
                 . fmap (VU.fromList . fmap getFeature . Too.unLabelList)
                 . Too.unVarList
                 )
          $ grouped
    pairwiseTests :: IO [Too.VarList (T.Text, T.Text)]
    pairwiseTests = mapM ( fmap Too.VarList
                         . mapM
                            ( sequence
                            . L.over
                                L._2
                                ( kruskalOrBust
                                . fmap
                                    ( VU.fromList
                                    . fmap getFeature
                                    . Too.unLabelList
                                    )
                                )
                                . Too.unCompare
                            )
                         . setupComparisonVar
                         )
                   $ grouped
    setupComparisonVar :: Too.VarList (Too.LabelList (Map.Map T.Text T.Text))
                       -> [Too.Compare (Too.LabelList (Map.Map T.Text T.Text))]
    setupComparisonVar = fmap ( Too.Compare
                              . L.over L._1 (T.intercalate "/")
                              . unzip
                              )
                       . (\x -> pairwise x :: [[(T.Text, Too.LabelList (Map.Map T.Text T.Text))]])
                       . fmap ( L.over L._2 Too.LabelList
                              . L.over L._1 (fromMaybe "" . headMay)
                              . unzip
                              . fmap (\ !x -> (fromMaybe "" $ compLabel x, x))
                              . Too.unLabelList
                              )
                       . Too.unVarList
    getFeature = maybe 0 (either error fst . T.double) . Map.lookup feature
    grouped :: [Too.VarList (Too.LabelList (Map.Map T.Text T.Text))]
    grouped = fmap ( Too.VarList
                   . fmap Too.LabelList
                   . groupBy ((==) `on` compLabel)
                   . sortBy (compare `on` compLabel)
                   )
            . groupBy ((==) `on` compVar)
            . sortBy (compare `on` compVar)
            $ ms
    compLabel = Map.lookup "statLabel"
    compVar x = (Map.lookup "Var1" x, Map.lookup "Var2" x)

-- -- | Add marksOther-markOther label if present to every group to compare with
-- -- all others.
  addOthersOthersToEachGroup
    : : [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
    - > [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
  addOthersOthersToEachGroup varLists = fmap addToVarList noOthersVarList
--   where
      noOthersVarList =
        filter ( not . ( \x - > isOthersList ( & & ) x & & isOthersList ( || ) x ) ) varLists
--     addToVarList xs = xs <> mconcat others
      others : : [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
      others = filter ( isOthersList ( & & ) ) varLists
      isOthersList : : ( Bool - > Bool - > Bool )
                   - > Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) )
--                  -> Bool
--     isOthersList f xs = fromMaybe False $ do
        var1 < - getVarFromVarList " Var1 " xs
--       var2 <- getVarFromVarList "Var2" xs
--       return $ f (var1 == "marksOther") (var2 == "marksOther")

-- -- | Add markOther label if present to every group to compare with
-- -- all others.
  addOthersToGroup : : [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
                   - > [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
  addOthersToGroup varLists = fmap addToVarList varLists
--   where
--     addToVarList xs = fromMaybe xs $ do
        var1 < - getVarFromVarList " Var1 " xs
--       others <- Map.lookup var1 otherMap
        return $ xs < > others
      otherMap = otherComparisonsMap varLists

-- -- | Get marksOther-marksOther label if exists.
-- otherComparisonsMap
    : : [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
    - > Map . Map T.Text ( Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) )
  otherComparisonsMap = Map.unions . mapMaybe getVarListMap
--   where
--     getVarListMap xs = do
        var1 < - getVarFromVarList " Var1 " xs
--       var2 <- getVarFromVarList "Var2" xs
--       guard (var2 == "marksOther")
        return $ Map.singleton var1 xs

-- | Return true if this is an other comparison row
isOther :: Map.Map T.Text T.Text -> Bool
isOther m = fromMaybe False $ do
      var1 <- Map.lookup "Var1" m
      var2 <- Map.lookup "Var2" m
      return (var1 == "marksOther" || var2 == "marksOther")

  | Get a Var column value from a VarList
getVarFromVarList :: T.Text
                  -> Too.VarList (Too.LabelList (Map.Map T.Text T.Text))
                  -> Maybe T.Text
getVarFromVarList var xs = (headMay . Too.unVarList $ xs)
                       >>= headMay . Too.unLabelList
                       >>= Map.lookup var
-- | Parse a file into CSV.
parseFile :: Maybe Too.StateLabelMap -> TU.FilePath -> IO [Map.Map T.Text T.Text]
parseFile slm file = do
  contents <- BL.readFile . T.unpack . TU.format TU.fp $ file
  Force handles to close
  let !rows = either error ( fmap (insertSampleLabel slm file)
                           . insertOldVar2
                           . F.toList
                           . snd
                           )
            . CSVStream.decodeByName
            $ contents
  return rows

-- | Insert samples and labels in a row. Labels are for plotting niceness.
insertSampleLabel :: Maybe Too.StateLabelMap
                  -> TU.FilePath
                  -> Map.Map T.Text T.Text
                  -> Map.Map T.Text T.Text
insertSampleLabel slm file m =
  Map.insert "label" (fromMaybe "No label" label)
    . Map.insert "statLabel" statLabel
    . Map.insert "sample" sample
    $ m
  where
    statLabel = maybe (fromMaybe "No label" alternateLabel) id label
    label
      | isOldVar2OtherOnly m = (\x y -> x <> "-" <> y)
                           <$> state
                           <*> (Just "marksOther")
      | otherwise = state
      where
        state = fmap Birch.unLabel
              . (=<<) (Map.lookup (Birch.Id sample) . Too.unStateLabelMap)
              $ slm
    alternateLabel = (\x y -> x <> "-" <> y)
                 <$> Map.lookup "Var1" m
                 <*> Map.lookup "Var2" m
    sample = Birch.unSample $ getSample file

-- | Insert the original Var2 for reference in the other comparison.
insertOldVar2 :: [Map.Map T.Text T.Text] -> [Map.Map T.Text T.Text]
insertOldVar2 ms = mapMaybe insertOldVar2 ms
  where
    insertOldVar2 m = do
      var2 <- Map.lookup "Var2" m
      relevantVar <- getRelevantVar m
      return
        . bool id (Map.insert "Var2" relevantVar) (isVar2OtherOnly m)
        . Map.insert "oldVar2" var2
        $ m
    getRelevantVar m = do
      var1 <- Map.lookup "Var1" m
      var2 <- Map.lookup "Var2" m
      if (var1 == var2)
        then return var1
        else do
  If Nothing , then it is Var1 vs. Var1 Other , so use Var1 .
          oldVar2 <- Just . fromMaybe var1 . headMay . filter (/= var1) $ vars
          return oldVar2
    vars = filter (/= "marksOther")
         . mapMaybe (Map.lookup "Var2")
         $ ms

-- | Check if Var2 is marksOther.
isVar2OtherOnly :: Map.Map T.Text T.Text -> Bool
isVar2OtherOnly m = fromMaybe False $ do
  var1 <- Map.lookup "Var1" m
  var2 <- Map.lookup "Var2" m
  return (var1 /= "marksOther" && var2 == "marksOther")

-- | Check if oldVar2 is marksOther.
isOldVar2OtherOnly :: Map.Map T.Text T.Text -> Bool
isOldVar2OtherOnly m = fromMaybe False $ do
  var1 <- Map.lookup "Var1" m
  var2 <- Map.lookup "oldVar2" m
  return (var1 /= "marksOther" && var2 == "marksOther")

  | Check if Var1 is marksOther .
isVar1Other :: Map.Map T.Text T.Text -> Bool
isVar1Other m = fromMaybe False $ do
  var1 <- Map.lookup "Var1" m
  return (var1 == "marksOther")

-- | Get sample from file path.
getSample :: TU.FilePath -> Birch.Sample
getSample = Birch.Sample . TU.format TU.fp . TU.dirname . p . p . p
  where
    p = TU.parent

-- | Remove columns with "marksOther".
removeOthers :: [Map.Map T.Text T.Text] -> [Map.Map T.Text T.Text]
removeOthers =
  fmap (Map.filterWithKey (\k _ -> not . T.isInfixOf "marksOther" $ k))

-- | Remove rows with "marksOther".
removeOthersRows :: [Map.Map T.Text T.Text] -> [Map.Map T.Text T.Text]
removeOthersRows = filter (\ x -> (not . isOther $ x)
                               && (Map.lookup "oldVar2" x /= Just "marksOther")
                          )

-- | Make sure all columns are represented in a row
fillColumns :: [Map.Map T.Text T.Text] -> [Map.Map T.Text T.Text]
fillColumns xs = fmap addDummy xs
  where
    addDummy = flip Map.union dummyColMap  -- Prefer original value, not dummy.
    dummyColMap = Map.fromList
                . fmap (\ !x -> (x, "NA"))
                . Set.toList
                . Set.fromList
                . concatMap Map.keys
                $ xs

plotSummary :: Too.OutputDirectory
            -> Too.IncludeOthersFlag
            -> Maybe Too.StateLabelMap
            -> Birch.Feature
            -> IO ()
plotSummary (Too.OutputDirectory inDir) iof slm feature = do
  let inDir' = TU.fromText . T.pack $ inDir
  statsFiles <- TU.reduce Fold.list . TU.find (TU.suffix "stats.csv") $ inDir'
  statsParsed <- mapM (parseFile slm) statsFiles

  when (null statsParsed) $ print "No stats.csv files found, first generate spatial results"

  let outDir = inDir' FP.</> "summary"

  TU.mktree outDir

  let outputBasename = "summary_" <> Birch.unFeature feature
      outputPlot = outDir FP.</> TU.fromText (outputBasename <> ".html")
      outputStats = outDir FP.</> TU.fromText (outputBasename <> ".csv")
      rows' = bool
                removeOthersRows
                (filter (not . isVar1Other))
                (Too.unIncludeOthersFlag iof)
            . mconcat
            $ statsParsed
      noLabelFlag = isNothing slm

  (rows, stats) <- pVal feature rows'

  let pValComparisons = fmap (T.intercalate "/" . fmap (fromMaybe ""))
                      . pairwise
                      . Set.toList
                      . Set.fromList
                      . fmap (Map.lookup "label")
                      $ rows'
      colorLabels = fmap ColorLabel
                  . Set.toAscList
                  . Set.fromList
                  $ fmap (fromMaybe "" . Map.lookup "label") rows
      feature' = Birch.unFeature feature
      dataSet = VL.dataFromColumns []
              . VL.dataColumn
                  "var1"
                  (VL.Strings . fmap (Map.findWithDefault "" "Var1") $ rows)
              . VL.dataColumn
                  "var2"
                  (VL.Strings . fmap (Map.findWithDefault "" "Var2") $ rows)
              . VL.dataColumn
                  "label"
                  (VL.Strings . fmap (Map.findWithDefault "" "label") $ rows)
              . VL.dataColumn
                  "sample"
                  (VL.Strings . fmap (Map.findWithDefault "" "sample") $ rows)
              . VL.dataColumn
                  "kwPValue"
                  ( VL.Numbers
                  . fmap
                      ( maybe 0 (either error fst . T.double)
                      . Map.lookup "kwPValue"
                      )
                  $ rows
                  )
              . (\ y
                -> foldl'
                    (\ acc x
                    -> VL.dataColumn
                        x
                        ( VL.Numbers
                        . fmap ( maybe 0 (either error fst . T.double)
                               . Map.lookup x
                               )
                        $ rows
                        ) acc
                    )
                    y
                    pValComparisons
                )
              $ VL.dataColumn
                  feature'
                  ( VL.Numbers
                  . fmap
                      ( maybe 0 (either error fst . T.double)
                      . Map.lookup feature'
                      )
                  $ rows
                  )
                  []
      transDens = transMax
                . VL.density feature' [ VL.DnGroupBy ["var1", "var2", "label"]]
      transHref = VL.calculateAs ("'../' + datum.sample + '/projections/' + datum.sample + '_projection.html'") "url"
      transMax = VL.joinAggregate
                  [ VL.opAs VL.Max feature' "max" ]
                  [ VL.WGroupBy ["var1", "var2"] ]
               . VL.calculateAs ("datum." <> feature' <> "/datum.max") "maxTrans"
               . transHref
      picked = "picked"
      sel = VL.selection
          . VL.select
              picked
              VL.Interval
              [ VL.Encodings [ VL.ChX, VL.ChY ], VL.BindScales ]
      axisSize = VL.Axis [ VL.TickWidth 0.756, VL.DomainWidth 0.756 ]
      densitySpec = [ VL.mark VL.Area [ VL.MOpacity 0.5]
                    , sel []
                    , VL.encoding
                    . VL.position
                        VL.Y
                        [ VL.PName "density"
                        , VL.PmType VL.Quantitative
                        ]
                    . VL.position
                        VL.X
                        [ VL.PName "value"
                        , VL.PmType VL.Quantitative
                        ]
                    . VL.color
                        [ VL.MName "label"
                        , VL.MmType VL.Nominal
                        , labelColorScale colorLabels
                        ]
                    $ []
                    , VL.transform $ transDens []
                    ]
      tickSpec = [ VL.mark VL.Tick []
                 , VL.transform $ transMax []
                 , VL.encoding
                 . VL.position
                    VL.X
                    [VL.PName feature', VL.PmType VL.Quantitative]
                 . VL.tooltips ( fmap
                                  (\x ->  [VL.TName x, VL.TmType VL.Nominal])
                                  ( [ feature'
                                    , "sample"
                                    , "label"
                                    , "kwPValue"
                                    ]
                                 <> pValComparisons
                                  )
                               )
                 . VL.color [ VL.MName "label"
                            , VL.MmType VL.Nominal
                            , labelColorScale colorLabels
                            ]
                 . VL.hyperlink [ VL.HName "url", VL.HmType VL.Nominal ]
                 $ []
                 ]
      boxSpec = [ VL.mark
                    VL.Boxplot
                    [ VL.MNoOutliers
                    , VL.MOpacity 0.5
                    , VL.MMedian [ VL.MColor "black" ]
                    ]
                , VL.transform $ transMax []
                , VL.encoding
                . VL.position
                    VL.X
                    [VL.PName feature', VL.PmType VL.Quantitative]
                . VL.position VL.Y [ VL.PNumber 30 ]
                . VL.color
                    [ VL.MName "label"
                    , VL.MmType VL.Nominal
                    , labelColorScale colorLabels
                    ]
                $ []
                ]
      res = VL.resolve
          . VL.resolution ( VL.RAxis
                              [ (VL.ChX, VL.Independent)
                              , (VL.ChY, VL.Independent)
                              ]
                          )
      p = VL.toVegaLite [ dataSet
                        , VL.specification
                        $ VL.asSpec
                            [ VL.layer
                                (fmap VL.asSpec [densitySpec, tickSpec, boxSpec])
                            ]
                        , VL.facet [ VL.RowBy
                                      [VL.FName "var1", VL.FmType VL.Nominal]
                                   , VL.ColumnBy
                                      [VL.FName "var2", VL.FmType VL.Nominal]
                                   ]
                        , res []
                        , VL.theme
                            ( VL.defaultConfig
                                { VL.configHeight = Just 170
                                , VL.configWidth = Just 200
                                , VL.configFontSize = Just 8
                                , VL.configTitleFontSize = Just 9.33333015
                                }
                            )
                            (VL.configuration axisSize [])
                        ]

  -- Output plot
  VL.toHtmlFile (T.unpack . TU.format TU.fp $ outputPlot) p

  -- Output stats
  let header = V.fromList
             . fmap (B.pack . T.unpack)
             . Set.toList
             . Set.fromList
             . concatMap Map.keys
             $ stats
  BL.writeFile (T.unpack . TU.format TU.fp $ outputStats)
    . CSV.encodeByName header
    . fillColumns
    $ stats

# LANGUAGE OverloadedStrings #
# LANGUAGE BangPatterns #
# LANGUAGE PackageImports #
 | Get all pairwise comparisons.
 | Add on the relevant p-values
 Descending
 -- | Add marksOther-markOther label if present to every group to compare with
 -- all others.
   where
     addToVarList xs = xs <> mconcat others
                  -> Bool
     isOthersList f xs = fromMaybe False $ do
       var2 <- getVarFromVarList "Var2" xs
       return $ f (var1 == "marksOther") (var2 == "marksOther")
 -- | Add markOther label if present to every group to compare with
 -- all others.
   where
     addToVarList xs = fromMaybe xs $ do
       others <- Map.lookup var1 otherMap
 -- | Get marksOther-marksOther label if exists.
 otherComparisonsMap
   where
     getVarListMap xs = do
       var2 <- getVarFromVarList "Var2" xs
       guard (var2 == "marksOther")
 | Return true if this is an other comparison row
 | Parse a file into CSV.
 | Insert samples and labels in a row. Labels are for plotting niceness.
 | Insert the original Var2 for reference in the other comparison.
 | Check if Var2 is marksOther.
 | Check if oldVar2 is marksOther.
 | Get sample from file path.
 | Remove columns with "marksOther".
 | Remove rows with "marksOther".
 | Make sure all columns are represented in a row
 Prefer original value, not dummy.
 Output plot
 Output stats
  TooManyCells . Spatial . SummaryPlot 
    

 Collects functions pertaining to plotting the summary of statistics for all 
 samples . 

Gregory W. Schwartz

Collects functions pertaining to plotting the summary of statistics for all
samples.
-}


module TooManyCells.Spatial.SummaryPlot
    ( plotSummary
    ) where

import Control.Exception (SomeException (..), try, evaluate)
import Control.Monad (when, mfilter, guard)
import Data.Bool (bool)
import Data.Function (on)
import Data.List (sortBy, groupBy, foldl', sort, maximumBy, zipWith4)
import Data.Maybe (fromMaybe, mapMaybe, isNothing)
import Ploterific.Plot.Plot (labelColorScale)
import Ploterific.Plot.Types (ColorLabel (..))
import Safe (headMay)
import System.Environment (getArgs)
import System.IO (hPutStrLn, stderr)
import TextShow (showt)
import qualified BirchBeer.Types as Birch
import qualified Control.Foldl as Fold
import qualified Control.Lens as L
import qualified Data.ByteString.Lazy.Char8 as BL
import qualified Data.ByteString.Char8 as B
import qualified Data.Csv.Streaming as CSVStream
import qualified Data.Csv as CSV
import qualified Data.Foldable as F
import qualified Data.Map.Strict as Map
import qualified Data.Sequence as Seq
import qualified Data.Set as Set
import qualified Data.Text as T
import qualified Data.Text.Read as T
import qualified Data.Vector.Unboxed as VU
import qualified Data.Vector as V
import qualified Graphics.Vega.VegaLite as VL
import qualified Graphics.Vega.VegaLite.Theme as VL
import qualified Statistics.Test.KruskalWallis as S
import qualified "statistics" Statistics.Quantile as S
import qualified "statistics" Statistics.Types as S
import qualified Filesystem.Path as FP
import qualified Turtle as TU

import qualified TooManyCells.File.Types as Too
import qualified TooManyCells.Spatial.Types as Too

pairwise :: (Eq a, Ord a) => [a] -> [[a]]
pairwise xs = Set.toList
            . Set.fromList
            . filter (\[x,y] -> x /= y)
            . fmap sort
            $ (\x y -> [x,y]) <$> xs <*> xs

  | Safer    test .
safeKWTest :: (VU.Unbox a, Ord a) => [VU.Vector a] -> IO Double
safeKWTest xs = do
  res <- try ( evaluate
             . maybe 1 (S.pValue . S.testSignificance)
             $ S.kruskalWallisTest xs
             ) :: IO (Either SomeException Double)
  res' <- case res of
            Left ex -> do
              hPutStrLn stderr $ "Caught exception, continuing with p = 1: " <> show ex
              return 1
            Right val -> return val
  return res'

pVal :: Birch.Feature
     -> [Map.Map T.Text T.Text]
     -> IO ([Map.Map T.Text T.Text], [Map.Map T.Text T.Text])
pVal (Birch.Feature feature) ms = do
  statRows' <- statRows
  statSummary' <- statSummary
  return (statRows', statSummary')
  where
    statRows = do
      tests' <- tests
      pairwiseTests' <- pairwiseTests
      return
        . mconcat
        . zipWith3
            (\ x xs ys
            -> fmap (\ m
                    -> foldl' (\acc (!a, !b) -> Map.insert a b acc) m (("kwPValue", x):xs)
                    )
            . concatMap Too.unLabelList
            . Too.unVarList
            $ ys
            )
            tests'
            (fmap Too.unVarList pairwiseTests')
        $ grouped
    statSummary = do
      tests' <- tests
      pairwiseTests' <- pairwiseTests
      return
        . mconcat
        . zipWith4
              (\ s x xs ys
              -> fmap (\ m
                      -> foldl'
                          (\acc (!a, !b) -> Map.insert a b acc)
                          m
                          (("highestLabels", s):("kwPValue", x):xs)
                      )
              . concatMap Too.unLabelList
              . Too.unVarList
              $ ys
              )
              highestLabels
              tests'
              (fmap Too.unVarList pairwiseTests')
          $ summarizedVarList
    highestLabels :: [T.Text]
    highestLabels = fmap ( T.intercalate "/"
                         . fmap showt
                         . concatMap
                             ( fmap
                                 (\ !x
                                 -> ( maybe
                                       (error "No median found")
                                       (either error fst . T.double)
                                    $ Map.lookup "median" x
                                    , Map.findWithDefault
                                       (error "No label found")
                                       "statLabel"
                                       x
                                    )
                                 )
                                 . Too.unLabelList
                             )
                         . Too.unVarList
                         )
                  $ summarizedVarList
    summarizedVarList :: [Too.VarList (Too.LabelList (Map.Map T.Text T.Text))]
    summarizedVarList = Too.VarList
                      . fmap ( Too.LabelList
                             . (:[])
                             . getStatSummaries
                             . Too.unLabelList
                             )
                      . Too.unVarList
                    <$> grouped
    getStatSummaries !ms = Map.fromList
                         $ ("median", T.pack . show $ getMedianFromMaps ms)
                         : ("feature", feature)
                         : foldl'
                            (\ acc x
                            -> ( x
                               , fromMaybe "" $ Map.lookup x =<< headMay ms
                               )
                               : acc
                            )
                            []
                            ["statLabel", "Var1", "Var2"]
    getMedianFromMaps = S.median S.s . VU.fromList . fmap getFeature
    kruskalOrBust = fmap (T.pack . show) . safeKWTest
    tests :: IO [T.Text]
    tests = mapM ( kruskalOrBust
                 . fmap (VU.fromList . fmap getFeature . Too.unLabelList)
                 . Too.unVarList
                 )
          $ grouped
    pairwiseTests :: IO [Too.VarList (T.Text, T.Text)]
    pairwiseTests = mapM ( fmap Too.VarList
                         . mapM
                            ( sequence
                            . L.over
                                L._2
                                ( kruskalOrBust
                                . fmap
                                    ( VU.fromList
                                    . fmap getFeature
                                    . Too.unLabelList
                                    )
                                )
                                . Too.unCompare
                            )
                         . setupComparisonVar
                         )
                   $ grouped
    setupComparisonVar :: Too.VarList (Too.LabelList (Map.Map T.Text T.Text))
                       -> [Too.Compare (Too.LabelList (Map.Map T.Text T.Text))]
    setupComparisonVar = fmap ( Too.Compare
                              . L.over L._1 (T.intercalate "/")
                              . unzip
                              )
                       . (\x -> pairwise x :: [[(T.Text, Too.LabelList (Map.Map T.Text T.Text))]])
                       . fmap ( L.over L._2 Too.LabelList
                              . L.over L._1 (fromMaybe "" . headMay)
                              . unzip
                              . fmap (\ !x -> (fromMaybe "" $ compLabel x, x))
                              . Too.unLabelList
                              )
                       . Too.unVarList
    getFeature = maybe 0 (either error fst . T.double) . Map.lookup feature
    grouped :: [Too.VarList (Too.LabelList (Map.Map T.Text T.Text))]
    grouped = fmap ( Too.VarList
                   . fmap Too.LabelList
                   . groupBy ((==) `on` compLabel)
                   . sortBy (compare `on` compLabel)
                   )
            . groupBy ((==) `on` compVar)
            . sortBy (compare `on` compVar)
            $ ms
    compLabel = Map.lookup "statLabel"
    compVar x = (Map.lookup "Var1" x, Map.lookup "Var2" x)

  addOthersOthersToEachGroup
    : : [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
    - > [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
  addOthersOthersToEachGroup varLists = fmap addToVarList noOthersVarList
      noOthersVarList =
        filter ( not . ( \x - > isOthersList ( & & ) x & & isOthersList ( || ) x ) ) varLists
      others : : [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
      others = filter ( isOthersList ( & & ) ) varLists
      isOthersList : : ( Bool - > Bool - > Bool )
                   - > Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) )
        var1 < - getVarFromVarList " Var1 " xs

  addOthersToGroup : : [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
                   - > [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
  addOthersToGroup varLists = fmap addToVarList varLists
        var1 < - getVarFromVarList " Var1 " xs
        return $ xs < > others
      otherMap = otherComparisonsMap varLists

    : : [ Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) ]
    - > Map . Map T.Text ( Too . VarList ( Too . LabelList ( Map . Map T.Text T.Text ) ) )
  otherComparisonsMap = Map.unions . mapMaybe getVarListMap
        var1 < - getVarFromVarList " Var1 " xs
        return $ Map.singleton var1 xs

isOther :: Map.Map T.Text T.Text -> Bool
isOther m = fromMaybe False $ do
      var1 <- Map.lookup "Var1" m
      var2 <- Map.lookup "Var2" m
      return (var1 == "marksOther" || var2 == "marksOther")

  | Get a Var column value from a VarList
getVarFromVarList :: T.Text
                  -> Too.VarList (Too.LabelList (Map.Map T.Text T.Text))
                  -> Maybe T.Text
getVarFromVarList var xs = (headMay . Too.unVarList $ xs)
                       >>= headMay . Too.unLabelList
                       >>= Map.lookup var
parseFile :: Maybe Too.StateLabelMap -> TU.FilePath -> IO [Map.Map T.Text T.Text]
parseFile slm file = do
  contents <- BL.readFile . T.unpack . TU.format TU.fp $ file
  Force handles to close
  let !rows = either error ( fmap (insertSampleLabel slm file)
                           . insertOldVar2
                           . F.toList
                           . snd
                           )
            . CSVStream.decodeByName
            $ contents
  return rows

insertSampleLabel :: Maybe Too.StateLabelMap
                  -> TU.FilePath
                  -> Map.Map T.Text T.Text
                  -> Map.Map T.Text T.Text
insertSampleLabel slm file m =
  Map.insert "label" (fromMaybe "No label" label)
    . Map.insert "statLabel" statLabel
    . Map.insert "sample" sample
    $ m
  where
    statLabel = maybe (fromMaybe "No label" alternateLabel) id label
    label
      | isOldVar2OtherOnly m = (\x y -> x <> "-" <> y)
                           <$> state
                           <*> (Just "marksOther")
      | otherwise = state
      where
        state = fmap Birch.unLabel
              . (=<<) (Map.lookup (Birch.Id sample) . Too.unStateLabelMap)
              $ slm
    alternateLabel = (\x y -> x <> "-" <> y)
                 <$> Map.lookup "Var1" m
                 <*> Map.lookup "Var2" m
    sample = Birch.unSample $ getSample file

insertOldVar2 :: [Map.Map T.Text T.Text] -> [Map.Map T.Text T.Text]
insertOldVar2 ms = mapMaybe insertOldVar2 ms
  where
    insertOldVar2 m = do
      var2 <- Map.lookup "Var2" m
      relevantVar <- getRelevantVar m
      return
        . bool id (Map.insert "Var2" relevantVar) (isVar2OtherOnly m)
        . Map.insert "oldVar2" var2
        $ m
    getRelevantVar m = do
      var1 <- Map.lookup "Var1" m
      var2 <- Map.lookup "Var2" m
      if (var1 == var2)
        then return var1
        else do
  If Nothing , then it is Var1 vs. Var1 Other , so use Var1 .
          oldVar2 <- Just . fromMaybe var1 . headMay . filter (/= var1) $ vars
          return oldVar2
    vars = filter (/= "marksOther")
         . mapMaybe (Map.lookup "Var2")
         $ ms

isVar2OtherOnly :: Map.Map T.Text T.Text -> Bool
isVar2OtherOnly m = fromMaybe False $ do
  var1 <- Map.lookup "Var1" m
  var2 <- Map.lookup "Var2" m
  return (var1 /= "marksOther" && var2 == "marksOther")

isOldVar2OtherOnly :: Map.Map T.Text T.Text -> Bool
isOldVar2OtherOnly m = fromMaybe False $ do
  var1 <- Map.lookup "Var1" m
  var2 <- Map.lookup "oldVar2" m
  return (var1 /= "marksOther" && var2 == "marksOther")

  | Check if Var1 is marksOther .
isVar1Other :: Map.Map T.Text T.Text -> Bool
isVar1Other m = fromMaybe False $ do
  var1 <- Map.lookup "Var1" m
  return (var1 == "marksOther")

getSample :: TU.FilePath -> Birch.Sample
getSample = Birch.Sample . TU.format TU.fp . TU.dirname . p . p . p
  where
    p = TU.parent

removeOthers :: [Map.Map T.Text T.Text] -> [Map.Map T.Text T.Text]
removeOthers =
  fmap (Map.filterWithKey (\k _ -> not . T.isInfixOf "marksOther" $ k))

removeOthersRows :: [Map.Map T.Text T.Text] -> [Map.Map T.Text T.Text]
removeOthersRows = filter (\ x -> (not . isOther $ x)
                               && (Map.lookup "oldVar2" x /= Just "marksOther")
                          )

fillColumns :: [Map.Map T.Text T.Text] -> [Map.Map T.Text T.Text]
fillColumns xs = fmap addDummy xs
  where
    dummyColMap = Map.fromList
                . fmap (\ !x -> (x, "NA"))
                . Set.toList
                . Set.fromList
                . concatMap Map.keys
                $ xs

plotSummary :: Too.OutputDirectory
            -> Too.IncludeOthersFlag
            -> Maybe Too.StateLabelMap
            -> Birch.Feature
            -> IO ()
plotSummary (Too.OutputDirectory inDir) iof slm feature = do
  let inDir' = TU.fromText . T.pack $ inDir
  statsFiles <- TU.reduce Fold.list . TU.find (TU.suffix "stats.csv") $ inDir'
  statsParsed <- mapM (parseFile slm) statsFiles

  when (null statsParsed) $ print "No stats.csv files found, first generate spatial results"

  let outDir = inDir' FP.</> "summary"

  TU.mktree outDir

  let outputBasename = "summary_" <> Birch.unFeature feature
      outputPlot = outDir FP.</> TU.fromText (outputBasename <> ".html")
      outputStats = outDir FP.</> TU.fromText (outputBasename <> ".csv")
      rows' = bool
                removeOthersRows
                (filter (not . isVar1Other))
                (Too.unIncludeOthersFlag iof)
            . mconcat
            $ statsParsed
      noLabelFlag = isNothing slm

  (rows, stats) <- pVal feature rows'

  let pValComparisons = fmap (T.intercalate "/" . fmap (fromMaybe ""))
                      . pairwise
                      . Set.toList
                      . Set.fromList
                      . fmap (Map.lookup "label")
                      $ rows'
      colorLabels = fmap ColorLabel
                  . Set.toAscList
                  . Set.fromList
                  $ fmap (fromMaybe "" . Map.lookup "label") rows
      feature' = Birch.unFeature feature
      dataSet = VL.dataFromColumns []
              . VL.dataColumn
                  "var1"
                  (VL.Strings . fmap (Map.findWithDefault "" "Var1") $ rows)
              . VL.dataColumn
                  "var2"
                  (VL.Strings . fmap (Map.findWithDefault "" "Var2") $ rows)
              . VL.dataColumn
                  "label"
                  (VL.Strings . fmap (Map.findWithDefault "" "label") $ rows)
              . VL.dataColumn
                  "sample"
                  (VL.Strings . fmap (Map.findWithDefault "" "sample") $ rows)
              . VL.dataColumn
                  "kwPValue"
                  ( VL.Numbers
                  . fmap
                      ( maybe 0 (either error fst . T.double)
                      . Map.lookup "kwPValue"
                      )
                  $ rows
                  )
              . (\ y
                -> foldl'
                    (\ acc x
                    -> VL.dataColumn
                        x
                        ( VL.Numbers
                        . fmap ( maybe 0 (either error fst . T.double)
                               . Map.lookup x
                               )
                        $ rows
                        ) acc
                    )
                    y
                    pValComparisons
                )
              $ VL.dataColumn
                  feature'
                  ( VL.Numbers
                  . fmap
                      ( maybe 0 (either error fst . T.double)
                      . Map.lookup feature'
                      )
                  $ rows
                  )
                  []
      transDens = transMax
                . VL.density feature' [ VL.DnGroupBy ["var1", "var2", "label"]]
      transHref = VL.calculateAs ("'../' + datum.sample + '/projections/' + datum.sample + '_projection.html'") "url"
      transMax = VL.joinAggregate
                  [ VL.opAs VL.Max feature' "max" ]
                  [ VL.WGroupBy ["var1", "var2"] ]
               . VL.calculateAs ("datum." <> feature' <> "/datum.max") "maxTrans"
               . transHref
      picked = "picked"
      sel = VL.selection
          . VL.select
              picked
              VL.Interval
              [ VL.Encodings [ VL.ChX, VL.ChY ], VL.BindScales ]
      axisSize = VL.Axis [ VL.TickWidth 0.756, VL.DomainWidth 0.756 ]
      densitySpec = [ VL.mark VL.Area [ VL.MOpacity 0.5]
                    , sel []
                    , VL.encoding
                    . VL.position
                        VL.Y
                        [ VL.PName "density"
                        , VL.PmType VL.Quantitative
                        ]
                    . VL.position
                        VL.X
                        [ VL.PName "value"
                        , VL.PmType VL.Quantitative
                        ]
                    . VL.color
                        [ VL.MName "label"
                        , VL.MmType VL.Nominal
                        , labelColorScale colorLabels
                        ]
                    $ []
                    , VL.transform $ transDens []
                    ]
      tickSpec = [ VL.mark VL.Tick []
                 , VL.transform $ transMax []
                 , VL.encoding
                 . VL.position
                    VL.X
                    [VL.PName feature', VL.PmType VL.Quantitative]
                 . VL.tooltips ( fmap
                                  (\x ->  [VL.TName x, VL.TmType VL.Nominal])
                                  ( [ feature'
                                    , "sample"
                                    , "label"
                                    , "kwPValue"
                                    ]
                                 <> pValComparisons
                                  )
                               )
                 . VL.color [ VL.MName "label"
                            , VL.MmType VL.Nominal
                            , labelColorScale colorLabels
                            ]
                 . VL.hyperlink [ VL.HName "url", VL.HmType VL.Nominal ]
                 $ []
                 ]
      boxSpec = [ VL.mark
                    VL.Boxplot
                    [ VL.MNoOutliers
                    , VL.MOpacity 0.5
                    , VL.MMedian [ VL.MColor "black" ]
                    ]
                , VL.transform $ transMax []
                , VL.encoding
                . VL.position
                    VL.X
                    [VL.PName feature', VL.PmType VL.Quantitative]
                . VL.position VL.Y [ VL.PNumber 30 ]
                . VL.color
                    [ VL.MName "label"
                    , VL.MmType VL.Nominal
                    , labelColorScale colorLabels
                    ]
                $ []
                ]
      res = VL.resolve
          . VL.resolution ( VL.RAxis
                              [ (VL.ChX, VL.Independent)
                              , (VL.ChY, VL.Independent)
                              ]
                          )
      p = VL.toVegaLite [ dataSet
                        , VL.specification
                        $ VL.asSpec
                            [ VL.layer
                                (fmap VL.asSpec [densitySpec, tickSpec, boxSpec])
                            ]
                        , VL.facet [ VL.RowBy
                                      [VL.FName "var1", VL.FmType VL.Nominal]
                                   , VL.ColumnBy
                                      [VL.FName "var2", VL.FmType VL.Nominal]
                                   ]
                        , res []
                        , VL.theme
                            ( VL.defaultConfig
                                { VL.configHeight = Just 170
                                , VL.configWidth = Just 200
                                , VL.configFontSize = Just 8
                                , VL.configTitleFontSize = Just 9.33333015
                                }
                            )
                            (VL.configuration axisSize [])
                        ]

  VL.toHtmlFile (T.unpack . TU.format TU.fp $ outputPlot) p

  let header = V.fromList
             . fmap (B.pack . T.unpack)
             . Set.toList
             . Set.fromList
             . concatMap Map.keys
             $ stats
  BL.writeFile (T.unpack . TU.format TU.fp $ outputStats)
    . CSV.encodeByName header
    . fillColumns
    $ stats
