Glucosamine sulfate is a chemical found in the human body. It is used by the body to produce a variety of other chemicals that are involved in building tendons, ligaments, cartilage, and the thick fluid that surrounds joints. Joints are cushioned by the fluid and cartilage that surround them.or example, the glucosamine sulfate that is put into dietary supplements is often harvested from the shells of shellfish. Glucosamine sulfate used in dietary supplements does not always come from natural sources. It can also be made in a laboratory.