Lump or bulge and Throat tightness. WebMD Symptom Checker helps you find the most common medical conditions indicated by the symptoms lump or bulge and throat tightness including Allergic reaction, Generalized anxiety disorder, and Panic attack. There are 16 conditions associated with lump or bulge and throat tightness. The links below will provide you with more detailed information on these medical conditions from the WebMD Symptom Checker and help provide a better understanding of causes and treatment of these related conditions. Allergic reaction.