Driving distance from Grand Junction, CO to Las Vegas, NV. The total driving distance from Grand Junction, CO to Las Vegas, NV is 508 miles or 818 kilometers. Your trip begins in Grand Junction, Colorado. It ends in Las Vegas, Nevada. If you are planning a road trip, you might also want to calculate the total driving time from Grand Junction, CO to Las Vegas, NV so you can see when you'll arrive at your destination.