Full Cream Milk vs Skimmed Milk. 1. Major Difference Between Skimmed Milk & Cream Milk. The full cream milk, also known as whole milk is the milk in the form we get them from animals while skimmed milk is whole milk from dairy cows that has had most of or all of its fat removed. So, if you are looking to burn down fat, you may not want to add to it by consuming more of whole milk.