Yiddish Meaning: 1  The name Reina is a Yiddish baby name. In Yiddish the meaning of the name Reina is: Clean. 2  The name Reina is an American baby name. In American the meaning of the name Reina is: Clean. 3  The name Reina is a French baby name. In French the meaning of the name Reina is: Queen. 4  The name Reina is a Spanish baby name. In Spanish the meaning of the name Reina is: Queen. Numerology. People with this name have a deep inner desire for a stable, loving family or community, and a need to work with others and to be appreciated.