Cook Pork Tenderloin to 145 F. According to the USDA, pork tenderloin must be cooked to a minimum internal temperature of 145 degrees Fahrenheit. After cooking, remove the meat from the heat and rest it for at least 3 minutes, which raises its temperature a bit more.n general, cooking the pork tenderloin over high heat for about 20 to 27 minutes per pound brings it to the required 145 F while preserving its inner juiciness. Whether pan-cooking the tenderloin on a stovetop, broiling it in an oven or cooking it on an indoor electric grill, the technique remains the same.