Sometimes symptoms of dry-eye occur right before or along with the eye twitching. Some research indicates that dry eyes are a trigger for blepharospasm. Eye twitching can run in families, or it can be caused by the side effects of certain medications, such as those used to treat Parkinson’s disease. Other common eye twitch causes include: 1  Stress. 2  Irritation of the Cornea or Conjunctiva. 3  Fatigue/Lack of sleep. 4  Prolonged staring at a computer screen or television. 5  Excessive caffeine intake (e.g., coffee, tea, caffeinated sodas). 6  Nervous system disorders.