Adrenal cortical carcinoma (ACC) is a rare disease. It is caused by a cancerous growth in the adrenal cortex, which is the outer layer of the adrenal glands. The adrenal glands lie on top of the kidneys. They play an important role in the endocrine system, which is the system that makes and regulates hormones.ACC is also known as adrenocortical carcinoma.The adrenal cortex makes hormones that regulate metabolism and blood pressure. It also produces cortisol and the male hormones known as androgens.reating an Adrenal Cortical Carcinoma. Your doctor will develop a treatment plan based on your condition, sex, age and overall physical health. He may also stage your cancer. Staging tells your doctor how advanced your cancer is. This can help determine the right treatment.