Pediatric ibuprofen (eg, Children's Advil, Children's Motrin) analgesic and antipyretic dosing. When possible, calculate ibuprofen dose based on weight using 4-10 mg/kg/dose. Give PO every 6-8 hours. Maximum single dose is 400 mg/dose, and maximum daily dose is 40 mg/kg/day up to 1200 mg/day. When weight is unknown, the below guideline based on age may be used. Motrin prescribing information.