substance-related disorder. Any disorder related to drug abuse or the effects of medication. Substances include alcohol, amphetamines, anxiolytics, cannabis, cocaine, hallucinogens, hypnotics, inhalants, methamphetamine, nicotine, opioids, phencyclidine (PCP), and sedatives.ubstance-related disorder. Any disorder related to drug abuse or the effects of medication. Substances include alcohol, amphetamines, anxiolytics, cannabis, cocaine, hallucinogens, hypnotics, inhalants, methamphetamine, nicotine, opioids, phencyclidine (PCP), and sedatives.