Suboxone is a combination of buprenorphine and naloxone. Buprenorphine is the synthetic opiate that prevents withdrawal symptoms in a person who quits using an addictive opiate, and naloxone is a drug intended to block the euphoric effects of the opiate.igns and Symptoms of Suboxone Use. Suboxone is a drug that was developed for treatment of addiction to drugs like heroin, hydrocodone, OxyContin, morphine, codeine, fentanyl and others.