Common symptoms of infection with the virus include mild headaches, maculopapular rash, fever, malaise, conjunctivitis, and arthralgia. The first well documented case of Zika virus was in 1964, beginning with a mild headache and progressing to a maculopapular rash, fever, and back pain.Within 2 days, the rash was fading, and within 3 days, the fever was gone and only the rash remained.There is no vaccine or preventive drug for Zika virus, and only treatment of symptoms is possible. Usually non-steroid anti-inflammatories and/or non-salicylic analgetics are used.ithin 2 days, the rash was fading, and within 3 days, the fever was gone and only the rash remained. There is no vaccine or preventive drug for Zika virus, and only treatment of symptoms is possible. Usually non-steroid anti-inflammatories and/or non-salicylic analgetics are used.