Freebase(0.00 / 0 votes)Rate this definition: Diltiazem. Diltiazem is a nondihydropyridine member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It is also an effective preventive medication for migraine. It is a class 3 antianginal drug, and a class IV antiarrhythmic.