Florence is a city in Boone County, Kentucky, United States. The population was 29,951 at the 2010 census. The Florence area was originally known as Crossroads, because of the convergence of several roads from Burlington and Union at Ridge Road (now U.S. 25). By 1821, the area was known as Maddentown, named for Thomas Madden, a Covington attorney who owned a farm on the Burlington Pike.