In adults, eczema occurs most frequently on the hands and elbows, and in bending areas such as the inside of the elbows and back of the knees. In young children, eczema is often seen on the elbows, knees, face, neck, and scalp. Signs and symptoms of atopic eczema include: 1  Itchiness. 2  Skin redness. 3  Dry, scaly, or crusted skin that might become thick and leathery from long-term scratching. 4  Formation of small, fluid-filled blisters that might ooze when scratched.