Saltville, Virginia. Saltville is a town in Smyth and Washington counties in the U.S. state of Virginia. The population was 2,077 at the 2010 census. It is part of the Kingsport–Bristol (TN)–Bristol (VA) Metropolitan Statistical Area, which is a component of the Johnson City–Kingsport–Bristol, TN-VA Combined Statistical Area – commonly known as the Tri-Cities region.