1 Beets, blackberries and rhubarb can turn urine red or pink. 2  Medications. Rifampin (Rifadin, Rimactane), an antibiotic often used to treat tuberculosis, can turn urine reddish orange — as can phenazopyridine (Pyridium), a drug that numbs urinary tract discomfort, and laxatives containing senna.  Medications.