Midrin, is a unique medication that can be used as a Migraine abortive or for tension-type headaches. It's a compound medication consisting of three ingredients-isometheptene mucate, dichloralphenazone, and acetaminophen.The isometheptene mucate helps reverse the vasodilation that sometimes occurs during a Migraine.Dichloralphenazone is a sedative, and acetaminophen is a simple analgesic.Midrin has been a problem to get for some time now. There was a shortage of one of the ingredients in 2007. That was followed by some kind of manufacturing issues the manufacturer (Caraco) had a bit later.ichloralphenazone is a sedative, and acetaminophen is a simple analgesic. Midrin has been a problem to get for some time now. There was a shortage of one of the ingredients in 2007. That was followed by some kind of manufacturing issues the manufacturer (Caraco) had a bit later.