Bromelain is a mixture of enzymes found in pineapples (Ananas comosus) that digest protein (proteolytic). Pineapple has been used for centuries in Central and South America to treat indigestion and reduce inflammation. Bromelain, which is derived from the stem and juice of the pineapple, was first isolated from the pineapple plant in the late 1800s. The German Commission E approved bromelain to treat swelling and inflammation after surgery, particularly sinus surgery. Bromelain can be used to treat a number of conditions.