1 Worst cases would involve skin tag removal surgery and the cost of having it removed would depend on the number of skin tags a person has. 2  On average, plan on spending anywhere from $75 to as much as $450 per procedure. 3  It will greatly depend upon the procedure that you choose to have performed. It will greatly depend upon the procedure that you choose to have performed. 2  At-home kits can cost anywhere from $30 to $150. 3  For instance, the highly rated Dermatend the Original Mole retails for $39 to $59. 4  Miracullum Spa is a spa located in California that performs skin tag removal.