Full Definition of SHRIVEL. intransitive verb. 1. : to draw into wrinkles especially with a loss of moisture. 2. a: to become reduced to inanition, helplessness, or inefficiency b: dwindle.transitive verb. : to cause to shrivel.See shrivel defined for English-language learners.See shrivel defined for kids. to become dry and wrinkled from heat, cold, or old age.