Negative pressure wound therapy is a medical procedure in which a vacuum dressing is used to enhance and promote wound healing in acute, chronic and burn wounds. The therapy involves using a sealed wound dressing attached to a pump to create a negative pressure environment in the wound.ses for Negative Pressure Wound Therapy. Several different types of wounds can benefit from negative pressure wound therapy such as: 1  diabetic ulcers. 2  venous ulcers. 3  arterial ulcers. 4  pressure ulcers. 5  first and second degree burns. 6  chronic wounds. 7  wounds with large amounts of drainage.