Font Size. A. A. A. You can treat most vaginal yeast infections with an over-the-counter vaginal cream or suppository. You can buy these nonprescription vaginal creams and suppositories at most large drugstores and supermarkets. Many yeast infection treatment doses come in one-day, three-day, and seven-day strengths.any of the over-the-counter vaginal creams and other products you can buy often contain the same ingredients to fight a yeast infection as the medication your doctor might prescribe -- but in less concentrated doses. Recommended Related to Women.