How long is the drive from Columbus, OH to Twinsburg, OH? The total driving time is 2 hours, 7 minutes. Your trip begins in Columbus, Ohio. It ends in Twinsburg, Ohio. If you're planning a road trip, you might be interested in seeing the total driving distance from Columbus, OH to Twinsburg, OH. You can also calculate the cost to drive from Columbus, OH to Twinsburg, OH based on current local gas prices and an estimate of your car's best gas mileage. If you're meeting a friend, you might be interested in finding the city that is halfway between Columbus, OH and Twinsburg, OH.