Ashanti Region. Ashanti is an administrative region in Ghana centrally located in the middle belt of Ghana. I t lies between longitudes 0.15W and 2.25W, and latitudes 5.50N and 7.46N. The region shares boundaries with four of the ten political regions, Brong-Ahafo in the north, Eastern region in the east, Central region in the south and Western region in the South west.