What Do High Creatinine Levels Mean. High creatinine means that the concentration of creatinine in the blood is higher than the normal range and this condition lasts for quite long time.The normal creatinine for men is 0.7-1.2 and it is 0.5-1.0 for women.Creatinine in the blood mainly comes from metabolism of muscles and meat products we eat.That is why men have higher creatinine then women because they usually have more muscle masses.he normal creatinine for men is 0.7-1.2 and it is 0.5-1.0 for women. Creatinine in the blood mainly comes from metabolism of muscles and meat products we eat. That is why men have higher creatinine then women because they usually have more muscle masses.