Voted by Hazlett Ixsander. In a 20 FL oz. bottle of Dr. Pepper there is 64 grams of sugar. In addition, a bottle of Dr. Pepper has 66 grams total carbohydrates, 100 mg sodium, and 250 calories. Dr. Pepper is made with high fructose corn syrup expect in a few markets where it is made with sugar. Dr. Pepper does not contain any fat or protein.