Safflower oil and grape seed oil are both great sources of unsaturated fats. These fats help to promote healthful levels of cholesterol in your bloodstream. However, grape seed oil is primarily composed of polyunsaturated fats and safflower oil is primarily made up of monounsaturated fats.rape seed oil has a high smoke point and begins to break down only after it reaches 420 degrees Fahrenheit. However, refined safflower oil's smoke point of 450 to 510 degrees Fahrenheit is much higher.