Answers. Best Answer: &nbsp A point mutation can be one of several types of mutations, as long as they affect only a single nucleotide or base. A single nucleotide insertion, a single nucleotide deletion, and a single base substitution are point mutations. A base substitution is one type of point mutation (it's when, well, a single base is changed in DNA, such as from adenine to guanine). Source(s): DNAunion · 2 years ago.