Treatment and medication varies from the result of diagnosis. The more severe diagnosis, the more complicated the treatment. Precautionary measures to relieve pain may be adopted before self-diagnosis. Following are the common prescribed drugs for normal Epigastric pain: 1  Cimetidine: It is usually prescribed in peptic ulcer and heartburn. 2  Antacids: It’s a substance that counterbalances stomach acidity. 3  Ranitidine: It is one of the histamine H2-receptor contenders that resist stomach acid production.