It is believed that mammals detect pheromones through an organ in the nose called the VNO (Vomeronasal Organ), and connects to the hypothalamus in the brain. The VNO in humans consists of just pits that probably do not do anything. If humans do respond to hormones, most likely they use their normal olfactory system.o humans have pheromones? 1  Releaser pheromones-they elicit an immediate response, the response is rapid and reliable. 2  Primer pheromones-these take longer to get a response. 3  Signaler pheromones-these provide information. 4  Modulator pheromones-they can either alter or synchronize bodily functions.