The largest denomination of currency ever printed by the Bureau of Engraving and Printing (BEP) was the $100,000 Series 1934 Gold Certificate featuring the portrait of President Wilson. This is the largest US dollar note bill ever printed. The present denominations of our currency in production are $1, $2, 5$, $10, $20, $50 and $100.This is the highest US dollar note bill currently in use. Source(s): http://www.ustreas.gov/education/faq/cur... lynn c · 6 years ago.