Gallstones may cause no signs or symptoms. If a gallstone lodges in a duct and causes a blockage, signs and symptoms may result, such as: 1  Sudden and rapidly intensifying pain in the upper right portion of your abdomen. 2  Sudden and rapidly intensifying pain in the center of your abdomen, just below your breastbone.3  Back pain between your shoulder blades.eek immediate care if you develop signs and symptoms of a serious gallstone complication, such as: 1  Abdominal pain so intense that you can't sit still or find a comfortable position. 2  Yellowing of your skin and the whites of your eyes.