Mupirocin (Bactroban®) is a prescription antibiotic. It is available in a skin ointment, a skin cream, and a nasal ointment. Each product is approved for different uses. Mupirocin skin ointment is used for treating impetigo due to Staphylococcus aureus or Streptococcus pyogenes. Impetigo is a skin infection that is quite common among young children. The skin cream is approved to treat secondarily infected traumatic skin lesions (infections that occur after an injury or wound to the skin).