Rome is in the Lazio region of central Italy on the Tiber river (Italian: Tevere). The original settlement developed on hills that faced onto a ford beside the Tiber Island, the only natural ford of the river in this area.ome is the national capital of Italy and is the seat of the Italian Government. The official residences of the President of the Italian Republic and the Italian Prime Minister, the seats of both houses of the Italian Parliament and that of the Italian Constitutional Court are located in the historic centre.