In many instances, clogged arteries do not cause any symptoms until a major event, such as a heart attack or stroke, occurs. At other times, especially when the the artery is blocked by 70% or more, the buildup of arterial plaque may cause symptoms that include: 1  Chest pain. 2  Shortness of breath. 3  Heart palpitations.4  Weakness or dizziness. 5  Nausea.6  Sweating.t other times, especially when the the artery is blocked by 70% or more, the buildup of arterial plaque may cause symptoms that include: 1  Chest pain. 2  Shortness of breath. 3  Heart palpitations. 4  Weakness or dizziness.