Strain RB51 vaccine must be administered by an accredited veterinarian or by a State or Federal animal health official. Calves must be vaccinated with the calf dose (10 to 34 billion organisms) between 4 and 12 months of age. Only animals in high risk areas should be vaccinated over 12 months of age.Vaccinates must be identified with the standard metal vaccination eartag and a vaccination tattoo.train RB51 vaccine must be administered by an accredited veterinarian or by a State or Federal animal health official. Calves must be vaccinated with the calf dose (10 to 34 billion organisms) between 4 and 12 months of age. Only animals in high risk areas should be vaccinated over 12 months of age.