Woodruff is a city in Spartanburg County, South Carolina, United States. The population was 4,090 at the 2010 census. Woodruff is located at 34°44′26″N 82°1′57″W / 34.74056°N 82.0325°W / 34.74056; -82.0325 (34.740530, -82.032580). According to the United States Census Bureau, the city has a total area of 3.7 square miles (9.6 km2), of which 0.04 square miles (0.10 km2), or 0.54%, is water.