wuss. n. Slang. A person regarded as weak, ineffectual, or overly fearful.[Perhaps blend of wimp and pussy, or short for.orrocks remarked; and his man Flethers is wuss, and have made such a row in the housekeeper's room about the dinners and hale, as no lord would make--but I think Miss Sharp's a match for'n, Sir Pitt, he added, after a pause. Vanity Fair by Thackeray, William Makepeace View in context.