Driving distance from Tucson, AZ to Los Angeles, CA. The total driving distance from Tucson, AZ to Los Angeles, CA is 489 miles or 787 kilometers. Your trip begins in Tucson, Arizona. It ends in Los Angeles, California. If you are planning a road trip, you might also want to calculate the total driving time from Tucson, AZ to Los Angeles, CA so you can see when you'll arrive at your destination.