Genital skin irritation in preschool-aged girls usually is caused by poor hygiene. Irritation of the skin around the vagina or the urethra may cause a burning pain when urine touches the irritated skin.Pain from genital skin irritation occurs more frequently in women and girls than it does in men and boys.enital skin irritation in preschool-aged girls usually is caused by poor hygiene. Irritation of the skin around the vagina or the urethra may cause a burning pain when urine touches the irritated skin.