Available in over-the-counter strength, it is usually sold as hydrocortisone. Hydrocortisone is a water-soluble, synthetic steroid sold under various names as a cream to relieve itching and minor skin irritation. It is also a primary ingredient in over-the-counter hemorrhoid medication.In prescription strength, cortisone cream may be prescribed to treat skin conditions that are unresponsive to over-the-counter products.t is also a primary ingredient in over-the-counter hemorrhoid medication. In prescription strength, cortisone cream may be prescribed to treat skin conditions that are unresponsive to over-the-counter products.