1 The cost may vary depending on the location, availability, supply, and demand. 2  Lowes.com, for example, offers OSB that ranges anywhere from $5 to as much as $35. 3  The prices greatly depend on the size. 4  For instance, a 7/16 x 4 x 8 sheet retails for $13 while a 23/32 x 4 x 8 sheet retails for $25. For example, the quality of the material, thickness, size or area, duration of the project, standard costs for labor, contractor, and location, among others may all have an impact on the OSB’s selling price. 2  Depending on the size, OSB is going to be between $10 to $40 per board. 3  Smaller panels can cost less than $10.