A laser mouse, better known as a wireless mouse, can stop operating correctly for a number of reasons: the signal from the mouse to the receiver is blocked, the batteries are low, the software to run the mouse isn't installed correctly or a different reason entirely.estart your computer if the mouse does not immediately work. Remove any other mouse software that might be installed (from a previous mouse, for example) by going to the Uninstall Programs menu, and choosing to uninstall the old mouse software.