Some people use peppermint oil to get rid of mice. Even though this is an environmentally friendly way to deter mice from entering your home, garage, barn, and farm equipment, it is not shown in independent comparisons to be the most effective Natural way to get rid of mice.roblems using Peppermint Oil As with any home remedy for getting rid of mice, the instructions for using peppermint oil are vague. There is no formula for figuring out how much peppermint oil to use for a particular area. You don’t know how often the peppermint oil needs to be changed.