Walkup and colleagues conclude that all three of the active treatments -- CBT, Zoloft, or the combination -- are effective short-term treatments for kids with anxiety disorders. Among these effective therapies, combination therapy provides the best chance for a positive outcome, they conclude.fter 12 weeks: 1  24% of the kids in the placebo group were very much or much improved. 2  55% of the kids in the Zoloft group were very much or much improved. 3  60% of the kids in the CBT group were very much or much improved.