Prokaryotic cells contain a single compartment enclosed within the cell membrane. In this space reside DNA, RNA, ribosomes and other molecules. Prokaryotes lack a defined nucleus (which is where DNA and RNA are stored in eukaryotic cells), mitochondria, ER, golgi apparatus, and so on.In addition to the lack of organelles, prokaryotic cells also lack a cytoskeleton.n this space reside DNA, RNA, ribosomes and other molecules. Prokaryotes lack a defined nucleus (which is where DNA and RNA are stored in eukaryotic cells), mitochondria, ER, golgi apparatus, and so on.