Mood stabilizers are the first line of medical treatment. These drugs, which include lithium (Eskalith, Lithobid) and anticonvulsants, help stabilize moods. Anticonvulsants used to treat bipolar disorder can include: 1  divalproex sodium (Depakote). 2  lamotrigine (Lamictal). 3  topiramate (Topamax). 4  oxcarbazepine (Trileptal).