GENERIC NAME: diclofenac and misoprostol. BRAND NAME: Arthrotec. DRUG CLASS AND MECHANISM: Arthrotec is a combination of diclofenac and misoprostol. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen (Motrin or Advil), naproxen (Naprosyn), and others that is used to treat inflammation, pain, and fever.