Extracts of Pulsatilla have been used to treat reproductive problems such as premenstrual syndrome and epididymitis. Additional applications of plant extracts include uses as a sedative and for treating coughs. It is also used as an initial ingredient in homeopathic remedies.ulsatilla is highly toxic, and produces cardiogenic toxins and oxytoxins which slow the heart in humans. Excess use can lead to diarrhea, vomiting and convulsions, hypotension and coma. It has been used as a medicine by Native Americans for centuries. Blackfoot Indians used it to induce abortions and childbirth.