(1) DNA has deoxyribose sugar, and RNA has ribose sugar. (2) DNA is made up of these four bases: adenine & guanine, cytosine & thymine; RNA is made up of adenine & guanine, cytosine & URACIL, the difference being that in RNA, uracil replaces thymine.(3) DNA is a double stranded molecule, and RNA is a single stranded molecule.here are three main ways in which DNA differs from RNA. First, RNA is single-stranded unlike DNA which is double-stranded. Second, DNA contains deoxyribose while RNA contains … ribose. Third, the base for adenine is thymine in DNA and uracil in RNA.