1 On average, plan on setting aside at least $100 to $200 for your dog’s first year of vaccinations. 2  Afterwards, it should cost $20 to $100 for each additional year. 3  A common, regular booster can range from $50 to $100. Afterwards, it should cost $20 to $100 for each additional year. 2  A common, regular booster can range from $50 to $100. 3  Other vaccinations such as Boratella, Rabies, and DHPP can range from $50 to $125. 4  These are very common vaccinations to be given out to dogs.