Category: Prescription Drugs. Generic Name: Nitrofurantoin. Mono Mac is a commonly used name for nitrofurantoin, an antibiotic that is used to prevent and treat urinary tract infections caused by susceptible strains of E. coli, S. aureus, Enterococcus, Klebsiella, and Enterobacter.See patients taking Nitrofurantoin Mono Mac.o not give nitrofurantoin to a child younger than 12 years old. Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.