Antidepressants approved by the Food and Drug Administration (FDA) to treat OCD include: 1  Clomipramine (Anafranil) for adults and children 10 years and older. 2  Fluoxetine (Prozac) for adults and children 7 years and older. 3  Fluvoxamine for adults and children 8 years and older.  Paroxetine (Paxil, Pexeva) for adults only.