The first two shots are given at least four weeks apart, and the third shot is given six to 12 months after the second shot. After the initial tetanus series, booster shots are recommended every 10 years.If you experience a puncture wound and it's been more than five years since your last tetanus shot — or you can't remember when you had your last tetanus shot — it's best to get the booster shot.With. James M. Steckelberg, M.D.1  Vaccination schedule.he first two shots are given at least four weeks apart, and the third shot is given six to 12 months after the second shot. After the initial tetanus series, booster shots are recommended every 10 years.