Zinc gluconate for acne. Research studies have shown that taking about 200 milligrams a day orally (corresponding to only about 30 mg of effective zinc) is effective in reducing acne inflammation due to zinc's action on inflamed cells and granulocytes. Zinc oxide for acne.Topical application of acne on the affected areas can reduce the production of sebum and oils on the area and can accelerate the healing of your zits. Chelating. skin is seen to be more effective in terms of zinc absorption.inc oxide for acne. Topical application of acne on the affected areas can reduce the production of sebum and oils on the area and can accelerate the healing of your zits. Chelating. skin is seen to be more effective in terms of zinc absorption.