Obredon (hydrocodone bitartrate and guaifenesin) Oral Solution is a combination opioid antitussive and expectorant used for symptomatic relief of cough and to loosen mucus associated with the common cold. The recommended adult dose of Obredon is 10 mL every 4 to 6 hours, not to exceed 6 doses (60 mL) in 24 hours.