Nociceptive pain is caused by an injury that stimulates pain receptors which recognize and react to a stimulus (pressure, extreme temperatures, irritating substances released by other cells) and send pain signals through the nervous system for recognition and response to an injury or the possibility for injury.ociceptive pain is caused by an injury that stimulates pain receptors which recognize and react to a stimulus (pressure, extreme temperatures, irritating substances released by other cells) and send pain signals through the nervous system for recognition and response to an injury or the possibility for injury.