Drinking alcohol while taking antidepressants is generally not advised because alcohol can make depression worse and it can increase the side effects of some antidepressants, such as drowsiness, dizziness and problems with co-ordination.f you’re not sure what type of antidepressant you’re taking and don’t know whether you should avoid alcohol, speak to your GP or pharmacist. You can also call NHS 111 for advice. It may help to check the patient information leaflet (PIL) that comes with your medication to see whether alcohol should be avoided.