Isolated intestinal (Small Bowel) Transplantation. In an isolated intestinal transplant, the diseased portion of the small intestine is removed and replaced with a healthy small intestine from a donor. In an isolated intestinal transplant, the disease limited to the small bowel only without liver failure.This procedure can be lifesaving for patients with irreversible intestinal failure that has become life-threatening.ntestinal Transplant Procedure. In an Intestinal transplant, the small intestine (small bowel) is surgically removed (along with any other diseased organs such as the liver), and replaced with healthy organ(s).