Yes, it can, through a pulmonary embolism: a sudden blockage in a lung artery. The blockage usually is due to a blood clot that traveled to the lung from a vein in the leg.Pu … lmonary embolism is a serious condition that can cause many health problems.If a blood clot is large, or if there are many clots, pulmonary embolism can cause death.he blockage usually is due to a blood clot that traveled to the lung from a vein in the leg. Pu … lmonary embolism is a serious condition that can cause many health problems.