Bisacodyl taken by mouth should produce a bowel movement within 6 to 12 hours. Bisacodyl used in the rectum can produce much faster results. You should have a bowel movement within 15 to 60 minutes after using a rectal suppository, or within 5 to 20 minutes after using the rectal enema. Do not take a rectal suppository or enema by mouth. It is for use only in your rectum. Try to empty your bladder just before using bisacodyl in the rectum. Wash your hands before and after using rectal bisacodyl. To use the rectal suppository: Remove the wrapper from the suppository.