Goiter associated with an overactive thyroid usually involves a high level of thyroid hormone in the blood and a lower than normal TSH level. ... thyroid hormone replacement with levothyroxine (Levothroid, Synthroid) will resolve the symptoms of hypothyroidism as well as ...he doctor will ask about your symptoms and medical and family history. ... diagnosis of hypothyroidism is made if the level of thyroid stimulating hormone (TSH) is elevated ... other reasons may raise concerns about hypothyroidism (eg, blood tests that show high cholesterol, anemia ...