Symptoms. The most common symptom of uterine cancer is abnormal vaginal bleeding. It may start as a watery, blood-streaked flow that gradually contains more blood. After menopause, any vaginal bleeding is abnormal. These are common symptoms of uterine cancer: 1  Abnormal vaginal bleeding, spotting, or discharge. 2  Pain or difficulty when emptying the bladder. 3  Pain during sex. 4  Pain in the pelvic area.