Ibuprofen (Advil, Motrin, and others) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of arthritis, primary dysmenorrhea (pain during your period), fever, and pain and inflammation from other conditions.Low-dose ibuprofen (200 mg) is available over the counter.otrin and Advil can be purchased over-the-counter in 200 milligram (mg) tablets, while higher doses require a prescription. Available in tablets and capsules, ibuprofen is also found in combination with other drugs sold over the counter for cough, cold, and migraine.