Children with CPP usually take Lupron via injection until they reach a normal age of puberty. Once Lupron injections are stopped, normal puberty functions begin again within a few weeks to a few months. Side effects of Lupron can include pain, burning, itching, and redness or swelling at the site of injection. In girls, some rare cases may experience vaginal bleeding or a white vaginal discharge. After several weeks of treatment, girls may experience side effects similar to those associated with menopause, including: Hot flashes; Vaginal dryness