A more expanded description of the Compendium and the Guidelines is attached. Compendium: CMS Definition and Needs The NCCN Compendium is a comprehensive listing of the drugs and biologics and the recommended uses for such agents in the treatment and management of patients with cancer.ne advantage of this complementary publication is that NCCN recommendations about the use of drugs and biologics can be viewed in the context of the continuum of care (e.g., surgery, radiation therapy). The exhaustive list of agents in the Compendium is continuously updated.