The nucleus usually has multiple (8, 16 or 32) overlapping lobes; megakaryocytes with few (2 or 4) lobes may occur in myelodysplasia. Nucleoli are absent, chromatin is coarse, cytoplasm is abundant, stains light blue or pink, and contains numerous purplish-red or pink granules. The N:C ratio is 1:1 to 1:2.