Sponsored Topics. Grayville is a city in Edwards and White counties in Illinois. The population was 1,725 at the 2000 census. Grayville is the birthplace of naval hero James Meredith Helm. Grayville is located at 38°15′33″N 87°59′48″W / 38.25917°N 87.99667°W / 38.25917; -87.99667 (38.259146, -87.996678).