The Duration of Physical Effects. The physical effects of nicotine withdrawal last the least amount of time. They peak around the third day and last about five days. Some people feel physical symptoms from nicotine cessation for up to two weeks. The following are factors that contribute to how long your physical symptoms will last: 1  Detoxification-It depends on how long it takes for your body to rid itself of the nicotine and return to a nicotine-free state.