This method allows the lowest dose to be administered for optimal results while avoiding any fluctuations due to mental or physical stress. From the time of insertion, it can take between 24 and 72 hours for the pellet hormones to adjust to your body and begin to take affect. According to E. Kapetanakis, W.P. Dmowski, F. Auletta and A. Scommegna, most women saw results within a few days.