These medicines may include: 1  Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, indomethacin, or naproxen. 2  Do not take aspirin, which should never be used to relieve pain during a gout attack. 3  Aspirin may change uric acid levels in the blood and may make the attack worse. 4  Be safe with medicines.his can reduce how often you have gout attacks and how severe they are. These medicines may include: 1  Uricosuric agents, to increase elimination of uric acid by the kidneys. 2  Xanthine oxidase inhibitors, to decrease production of uric acid by the body.