Diseases of the adrenal gland (such as Addison's disease, that causes a decreased aldosterone secretion) lead to a decrease in kidney excretion of potassium resulting in hyperkalemia. Examples of medications that may lead to elevated potassium levels include: 1  nonsteroidal antiinflammatory drugs, 2  ACE inhibitors, 3  Angiotensin II receptor blockers (ARBs), and.  some types of diuretics.