Sarcoidosis. Sarcoidosis is an autoimmune disease in which tiny clumps of inflammatory cells develop in different areas of the body. Sarcoidosis most commonly affects the lungs, lymph nodes, eyes and skin.Symptoms vary depending on which organ is affected and how far the disease has progressed.hile localized scleroderma affects the skin, systemic scleroderma can attack the internal organs such as the lungs, kidneys, heart and digestive tract. Scleroderma symptoms vary based on where the disease originates but can include gastroesophageal reflux disease which, over time can damage the esophagus.