Report Abuse. 2lb Eye Round Roast Roast at 325º for 1.5hrs for medium-rare, I suggest using a meat thermometer-you should pull it out when internal temp hits 135ºF, then cover with foil and let rest for 15-20 minutes before slicing.SweetMeatBalls · 2 years ago.lb Eye Round Roast Roast at 325º for 1.5hrs for medium-rare, I suggest using a meat thermometer-you should pull it out when internal temp hits 135ºF, then cover with foil and let rest for 15-20 minutes before slicing. SweetMeatBalls · 2 years ago.