Heart-Related Causes of Chest Pain. 1  heart attack. 2  angina—chest pain due to blockages in the blood vessels leading to your heart. 3  pericarditis—inflammation of the sac around the heart.  myocarditis—inflammation of the heart 1  muscle. cardiomyopathy—heart muscle disease.  aortic dissection—a rare condition involving rupture of the heart’s main artery.