From Wikipedia, the free encyclopedia. (Redirected from Most wins by a starting quarterback (NFL)). Brett Favre, the all-time leader in regular season wins by an NFL quarterback. In the National Football League the quarterback is the only position player to be credited with a record of wins and losses as a starter. The 0 bronze star denotes the team for which quarterback had the most career wins. By clicking once on the Teams heading then twice on the, quarterbacks with most career wins for that team are listed together, and in order of wins for that team. Reload page to return to original configuration.