If you do have active TB disease, you may have these symptoms: 1  Overall sensation of feeling unwell. 2  Cough, initially with yellow or green mucus, and possibly with bloody sputum later in the disease. 3  Fatigue. 4  Shortness of breath. 5  Weight loss. 6  Fever. 7  Night sweats. 8  Pain in the chest, back or kidneys, or perhaps in all three.