An enzyme that is denatured is one that no longer functions correctly or one that has ceased to function entirely. An enzyme can become denatured if factors such as pH and tem … perature are not closely monitored.8 people found this useful. Deb Answers.n enzyme that is denatured is one that no longer functions correctly or one that has ceased to function entirely. An enzyme can become denatured if factors such as pH and tem … perature are not closely monitored. 8 people found this useful. Deb Answers.