The dermis is the middle layer of skin. It is the thickest skin layer and is made up of two sublayers that contain small blood and lymph vessels, nerves, hair follicles, sweat and oil glands, and nerve receptors to sense touch, temperature, pressure, position, and pain.he dermis is the thick layer of skin underneath the dry surface layer of the skin. It contributes a lot to how we look and changes in the dermis make us look older. Watch the animation to see all the skin structures.