EPA assesses the cancer risk associated with exposure to the pesticide in food over the course of a person's lifetime. EPA then determines whether that cancer risk can be considered negligible. In general, EPA will grant a tolerance and register any pesticide that poses a negligible or no-cancer risk. The notion of negligible risk is an attempt to set a standard below which the cancer risk is so small that there is no cause for worry from a regulatory or public health perspective. EPA's pesticide program defines a negligible risk a one-in-a-million or less chance of getting cancer as a direct result of a lifetime of exposure to a particular substance.