Scalp pain is a common symptom of head injury, headaches, and skin conditions. It may result from trauma to the head region, including the brain, skull or scalp. It can occur in conditions that cause headaches or skin irritation, or in more generalized conditions, such as cancer.Trauma to the head is a common cause of scalp pain.It includes brain injury, skull fracture, or concussion, all of which may occur immediately after the traumatic episode or up to several hours or days afterward.ther conditions can result in pain, infection or irritation to the scalp, such as contact dermatitis, lesions from head lice, and basal cell carcinoma or other skin cancers. Scalp pain can indicate a serious condition.