“The average cost of HIV treatment is $14,000 to $20,000 a year,” says Michael Kolber, MD, a professor of medicine and director of the Comprehensive AIDS Program and Adult HIV Services at University of Miami Miller School of Medicine in Florida.dditional infections can also increase cost. For example, data suggests that a year of optimal HIV treatment costs $18,300 or more while 48 weeks of treatment for HIV and hepatitis C together will cost $29,000 or more.