However, some people do not need to take furosemide every day, especially people taking it for fluid retention. Because furosemide increases urination, it is best to take it in the morning (to avoid needing to get up to use the bathroom throughout the night). If you take furosemide multiple times per day, it is best to take the last dose of the day before 6 p.m. (unless you are instructed otherwise). For furosemide to work properly, it must be taken as prescribed. Furosemide will not work if you stop taking it.