After a decade as a stage actress based in New York City, she moved to Los Angeles and has appeared in various movies, TV shows and mini-series. Weigert is best known for her much-lauded portrayal of the unkempt, foul-mooded, foul-mouthed drunkard Calamity Jane in the HBO television series Deadwood. In 2004, Weigert was nominated for an Emmy for Outstanding Supporting Actress in a Drama Series for the role.