Lyme disease can produce a range of symptoms, including rash, fever, and joint pain. Most people recover fully with early antibiotic treatment. However, treatment becomes more difficult if symptoms are missed or misdiagnosed. Without treatment, people can experience more severe or prolonged symptoms. Back to top. Signs and symptoms of Lyme disease Lyme disease can affect the entire body, including the skin, joints, nervous system, and heart. Signs and symptoms of Lyme may differ depending on the type of bacterial infection and stage of the disease.