The smooth endoplasmic reticulum has functions in several metabolic processes, including synthesis of lipids, metabolism of carbohydrates and calcium concentration, drug detoxification, and attachment of receptors on cell membrane proteins.It is connected to the nuclear envelope.Smooth endoplasmic reticulum is found in a variety of cell types (both animal and plant) and it serves different functions in each. The Smooth ER also contains the enzyme Glucose-6-phosphatase which converts glucose-6-phosphate to glucose, a step in gluconeogenesis.onfidence votes 185. The smooth endoplasmic reticulum has functions in several metabolic processes, including synthesis of lipids, metabolism of carbohydrates and calcium concentration, drug detoxification, and attachment of receptors on cell membrane proteins. It is connected to the nuclear envelope.