The following represent many of the different ways that hands can be affected by anxiety. Note that anxiety and stress are powerful conditions, and it's possible that your affected hand symptoms are not listed below: Shaking The most common hand symptom of anxiety is a restless shaking. This shaking has an obvious cause. When you suffer from anxiety, your body rushes with adrenaline - a hormone that gives your body a tremendous amount of energy, which - when unused - leads to physical agitation. That causes your hands and legs to shake, often visibly.