glipizide dosing for type 2 diabetes your healthcare provider may increase your dose slowly if necessary up to a maximum of 40 mg total per day for people taking more than 15 mg of glipizide per day the dose should be split up into at least two doses and taken before mealsfor extended release glipizide the recommended starting dose is glipizide extended release 5 mg taken once daily with breakfasthe dosage of glipizide glucotrol or glipizide extended release glucotrol xl your healthcare provider prescribes will vary depending on a number of factors including