Ramez Salem)(Williams & Wilkens) *The process involved in making fibrin glue may not be acceptable to everyone. See Also Custom Google Search for Fibrin Glue. Fibrin glue is a human-derived tissue adhesive that may be used for hemostasis and sealing of tissues.This biological glue can be manufactured from clotting factors taken from donor plasma (fibrinogen, cyroprecipitate and thrombin) or made intraoperatively out of fibrinogen coming from the patient's own blood*.he elastic property, tensile strength, and tissue adhesiveness of plasma fibrin glue or sealant has made it an important adjunct in microsurgical techniques, conventional hemostasis, cardiopulmonary bypass surgery, colostomy closure and splenic injury repair.