1 Depending on the breed, plan on spending at least $500 to as much as $2,000 per puppy with no complications. 2  Breeding a litter of four puppies could run you upwards of $8,000.3  The costs noted below would be what it would cost for a litter of four. According to Omalmalamutes.com, it can cost an average of $7,788 for a litter of four Malamute Puppies without complications to as much as $23,899 for a litter of 12 with no complications.