Answers. Best Answer: Cell-to-Cell communication is absolutely essential for multicellular organisms. The billions of cells of a human or an oak tree must communicate in order to develop from a fertilized egg and then survive and reproduce in turn.Communication among cells is also important for many unicellular organisms that must locate food and find mates in order to sexually reproduce.he process by which a signal on a cell's surface is converted into a specific cellular response, a series of steps called a signal-transduction pathway, has been extensively studied in many types of cells.