The advent of a new class of drugs known as biologics has revolutionized the treatment of rheumatoid arthritis (RA). These drugs, which include Cimzia, Enbrel, Humira, Kineret, Orencia, Remicade, Rituxan, and Simponi, must be given via self-injection or intravenous infusion in the doctor’s office or hospital.They also can be expensive and are not always covered by insurance.hese drugs, which include Cimzia, Enbrel, Humira, Kineret, Orencia, Remicade, Rituxan, and Simponi, must be given via self-injection or intravenous infusion in the doctor’s office or hospital. They also can be expensive and are not always covered by insurance.