U.S. Route 61 (US 61) is the official designation for a United States highway that runs 1,400 miles (2,300 km) from New Orleans, Louisiana, to the city of Wyoming, Minnesota. The highway generally follows the course of the Mississippi River, and is designated the Great River Road for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota, is at an intersection with Interstate 35 (I-35).