Meaning of “loathing” in the English Dictionary. See all translations. uk ​ /ˈləʊ.ðɪŋ/ us ​ /ˈloʊ.ðɪŋ/ formal. C2 a strong feeling of hating someone or something: The thought of him touching her filled her with deep loathing. He approached his enemy with fear and loathing.