Hydrocodone/APAP and Pregnancy Category C. The acetaminophen component of hydrocodone/APAP is usually considered safe for pregnant women (see Tylenol and Pregnancy) . However, the hydrocodone component may not be safe.When given to pregnant hamsters, a single dose of hydrocodone increased the risk of birth defects, including cranial defects.Limited human studies also indicate that hydrocodone may increase the risk of similar birth defects in humans.ydrocodone/APAP and Pregnancy Category C. The acetaminophen component of hydrocodone/APAP is usually considered safe for pregnant women (see Tylenol and Pregnancy) . However, the hydrocodone component may not be safe.