Here’s what you should know if you’re considering taking Cialis. How Quickly Cialis Works and How Long It Lasts. Cialis tends to take effect more quickly than other ED drugs, with onset of effectiveness within 30 minutes typically.The recommendation is to take Cialis 30 minutes prior to sexual activity, while with Viagra and Levitra, users are instructed to take the drug 60 minutes before sexual activity.Generally, the effects of Cialis last 24 to 36 hours after taking it.The fact that the effects are so long-lasting has been a major selling point for Cialis, which branded itself “the weekend pill.” Many men like that they can take Cialis Friday night, and still experience its effects Sunday morning.ialis: How to Take it and How Long it Lasts. Posted by: Mary Hiers in Cialis April 8, 2014 Comments Off on Cialis: How to Take it and How Long it Lasts 28329 Views. Cialis is a drug used to treat erectile dysfunction (ED). Cialis is among the top 100 selling drugs in the world.