Lady Macbeth is a character in Shakespeare 's Macbeth (c.1603–1607). She is the wife to the play's protagonist, Macbeth, a Scottish nobleman. After goading him into committing regicide, she becomes Queen of Scotland, but later suffers pangs of guilt for her part in the crime.hakespeare's Lady Macbeth appears to be a composite of two personages found in the account of King Duff and in the account of King Duncan in Holinshed's Chronicles (1587).