For example, eat 250 calories fewer than the number of calories you need to maintain your weight and workout to burn off 250 calories per day, and you'll lose a pound per week. Cutting 250 calories can be as easy as skipping a roll at dinner to save 87 calories, eliminating one tablespoon of mayonnaise from your sandwich to save 95 calories and skipping one ounce of cheese on morning eggs to save 114 calories.