Beta blockers work by blocking the effects of epinephrine, also known as adrenaline, on the body. Beta blockers slow the heart rate, so it requires less oxygen and blood to effectively pump. Beta blockers can also raise triglycerides levels slightly, although the effect may be temporary.hile the tendency to develop high triglyceride levels can be inherited, triglyceride levels can also rise due to medical conditions such as diabetes, obesity and liver disease. Certain types of medications also can raise triglyceride levels over the normal limit of 150 milligrams per deciliter (mg/dL).