The neurons of the upper motor neuron system are located in the cerebral cortex (Figure 103.1[1]), basal ganglia (Figure 103.1[2]), cerebellar nuclei (Figure 103.1[3]), red nuclei (Figure 103.1[4), reticular formation (Figure 103.1[5]), and the lateral vestibular nucleus (Figure 103.1[6]).hese axons travel through the brain and brainstem to make contact with the motor neurons in the brainstem and through the brain, brainstem, and spinal cord (Figure 103.1[4]) to make contact with the motor neurons in the anterior horn of the spinal cord.