Sponsored Topics. Yoakum is a city in DeWitt and Lavaca Counties in the U.S. state of Texas. The population was 5,731 at the 2000 census. Yoakum is located at 29°17′28″N 97°8′50″W / 29.29111°N 97.14722°W / 29.29111; -97.14722 (29.291052, -97.147315).