In most cases, cracked mouth corners are not caused by a serious condition and do not affect your overall health. Common causes of cracked mouth corners include dry or cold weather, sunburn, wind exposure, licking your lips, and breathing through your mouth.In some cases, conditions such as the common cold, anemia, dehydration, and nutritional deficiencies may also result in cracked mouth corners.racked mouth corners are rarely associated with a medical emergency. However, cracked mouth corners may be a sign of dehydration. Severe dehydration and electrolyte imbalances can result in shock or coma and may be life threatening.