Sertraline Hydrochloride Tablets are the generic version of Pfizer's Zoloft(R), which had U. The Company's Sertraline Hydrochloride Tablets, 25 mg, 50 mg and 100 mg are indicated for the treatment in adults of major depressive disorder. Food and Drug Administration has granted tentative approval for the company's ANDA for sertraline hydrochloride 25 mg, 50 mg, and 100 mg tablets.