Guardia Sanframondi is a town and comune in the Province of Benevento, Campania region, Italy.It is best known for the penitential rite held every seven years.uch of the old town is vacant, as citizens prefer the new homes and shops that ring the old town, because they are accessible by automobile. Some houses in the old town are being purchased and rehabilitated by Neapolitans as weekend retreats. The town is the center of the Titerno Local Action Group.