PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells.Mazzocchi G, Aragona F, Malendowicz LK, Nussdorfer GG. Section of Anatomy, Department of Human Anatomy and Physiology, University of Padua, Via Gabelli 65, I-35121 Padua, Italy.t is concluded that PTH and PTH-RP exert a sizeable secretagogue action on the human adrenal cortex, probably acting through the PTH/PTH-RP receptor coupled with both adenylate cyclase/PKA-and PLC/PKC-dependent signaling cascades.