From Wikipedia, the free encyclopedia. In the kidney, the loop of Henle (or Henle's loop, nephron loop or its Latin counterpart ansa nephroni) is the portion of a nephron that leads from the proximal convoluted tubule to the distal convoluted tubule.y means of a countercurrent multiplier system, which utilizes electrolyte pumps, the loop of Henle creates an area of high urea concentration deep in the medulla, near the papillary duct in the collecting duct system.