Rating Newest Oldest. Best Answer: 1. home slice: synonomous to homie. def 1: means good friend or buddy def 2: means someone who seems like a little slice of home, thus home slice.Hey whassup home slice. 2.Someone who is an over the top dork.Someone who is trying way too hard to be cool and fails miserably.ef 1: means good friend or buddy def 2: means someone who seems like a little slice of home, thus home slice. Hey whassup home slice.