Registered Nurse vs. LPN. Even though they sound similar, licensed practical nurses and registered nurses have little in common in terms of job tasks, educational paths, and salary ranges. LPNs usually provide more basic nursing care and are responsible for the comfort of the patient.RNs on the other hand, primarily administer medication, treatments, and offer educational advice to patients and the public. Here's a breakdown of the key distinctions between these two in-demand positions.PNs usually provide more basic nursing care and are responsible for the comfort of the patient. RNs on the other hand, primarily administer medication, treatments, and offer educational advice to patients and the public. Here's a breakdown of the key distinctions between these two in-demand positions.