This medication is used to treat vaginal yeast infections. Miconazole reduces vaginal burning, itching, and discharge that may occur with this condition. This medication is an azole antifungal. It works by stopping the growth of yeast (fungus) that causes the infection.ake sure to insert the correct cream for use inside the vagina, not the skin cream for use on the outer genital area (vulva). If using the vaginal tablet, you may use either the applicator or your finger to insert the tablet.