Pseudoxanthoma elasticum (PXE), also known as Groenblad–Grönblad strandberg, syndrome is a genetic disease that causes fragmentation and mineralization of elastic fibers in some. Tissues the most common problems arise in the skin and, eyes and later in blood vessels in the form of premature. atherosclerosishe first description of PXE that distinguished it from other xanthomatous conditions was by Dr Ferdinand-Jean Darrier in 1896. The eponym Groenblad-Grönblad strandberg syndrome is used in older, literature after two physicians who made further discoveries in the disease. manifestations