American Meaning: The name Isaac is an American baby name. In American the meaning of the name Isaac is: Laughter. Hebrew Meaning: The name Isaac is a Hebrew baby name. In Hebrew the meaning of the name Isaac is: He laughs.Laughter. The only son born to Abraham and his wife Sarah (in the Old Testament).Famous Bearers: British scientist Sir Isaac Newton (1642-1727) and the great violinist Itzhak Perlman.ebrew Meaning: The name Isaac is a Hebrew baby name. In Hebrew the meaning of the name Isaac is: He laughs. Laughter. The only son born to Abraham and his wife Sarah (in the Old Testament).