If YOU Have Heart Disease. If you have heart disease, work with your doctor on how often you should have your lipid panel done. Depending on your treatment, you may have your triglycerides and cholesterol checked as often as every two months.f you are a diabetic or have pre-diabetes, or if you are overweight, have your triglycerides checked at least every year. If your triglycerides are above 150 mg/dl, it is best to check more often. Triglycerides, unless you are dealing with genetic issues, respond very nicely to changes in your diet and lifestyle.