1 If your insurance policy does cover this vaccine, it will cost less than $45,on average. 2  TheTravelClinic.com, located in Oregon, charges $70 for four capsules. 3  According to JohnnyVagabond.com, it is claimed that one person paid $160 for a single typhoid vaccine.4  Others quoted as much as $500 for a package of vaccines. The oral vaccine is not recommended for those who have cancer of any kind. 2  Also, the oral vaccine should not be taken within 24 hours of intake of any antibiotics. 3  The typhoid vaccine does not guarantee 100 % protection from disease, so you should be careful against this disease even if you are vaccinated.