You definitely need to get your female spayed but it would be safe to wait a few months after she is out of heat. Some males are capable of breeding around 5 months old so to be safe it would be best to get you girl spayed before the male reaches that age.Females generally come in heat every 6 to 12 months.ou definitely need to get your female spayed but it would be safe to wait a few months after she is out of heat. Some males are capable of breeding around 5 months old so to be safe it would be best to get you girl spayed before the male reaches that age.