0. 0. Psychosomatic means mind (psyche) and body (soma). A psychosomatic disorder is a disease which involves both mind and body. Some physical diseases are thought to be particularly prone to be made worse by mental factors such as stress and anxiety.o an extent, most diseases are psychosomatic-involving both mind and body. 1  There is a mental aspect to every physical disease. 2  How we react to and cope with disease varies greatly from person to person.