Encapsulation of hydrophobic drugs in Pluronic F127 micelles: effects of drug hydrophobicity, solution temperature, and pH.Basak R(1), Bandyopadhyay R. Author information: (1)Raman Research Institute, Bangalore, India.ncreasing solution pH leads to the ionization of the drugs incorporated in the micellar cores. This causes rupture of the micelles and release of the drugs into the solution at the highest solution pH value of 11.36 investigated here and is studied using DLS and fluorescence spectrocopy. [PubMed-indexed for MEDLINE].