Although it is very uncommon in men, there are other types of hyperthyroidism that are more common in men, like Toxic Nodular. 1. They both are forms of hyperthyroidism, 2. heart palpitations are a symptom of both, 3. weight loss is a common symptom. Here are the differences between them. Graves disease mostly effects women, while toxic nodular mostly effects men. Graves disease is genetic, while toxic nodular is aquired environmentally (anything that speeds up your BMR to the point that you are hyperthyroid, overexercise, certain medications, and overconsumption of B vitamins, Iodine, or zinc.