For Tourette’s syndrome and ADHD, clonidine is usually given once a day to start with. This can be in the morning OR the evening. Your doctor may then suggest that you give it two or three times a day, depending on how much your child needs. 1  Twice each day: this is once in the morning and once in the evening. 2  Ideally, these times are. 3  10–12 hours apart, for example some time between 7 am and 8 am, and between 7 pm and 8 pm.