Impetigo typically is treated with an antibiotic ointment or cream that you apply directly to the sores. You may need to first soak the affected area in warm water or use wet compresses to help remove the scabs so the antibiotic can penetrate the skin. If you have more than just a few impetigo sores, your doctor might recommend antibiotic drugs that can be taken by mouth. Be sure to finish the entire course of medication even if the sores are healed. This helps prevent the infection from recurring and makes antibiotic resistance less likely.