Tresiba Prices. This Tresiba price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. The cost for Tresiba subcutaneous solution (100 units/mL) is around $471 for a supply of 15 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. Tresiba is available as a brand name drug only, a generic version is not yet available.