The hypothalamus works with other parts of the body's temperature-regulating system, such as the skin, sweat glands and blood vessels — the vents, condensers and heat ducts of your body's heating and cooling system.he middle layer of the skin, or dermis, stores most of the body's water. When heat activates sweat glands, these glands bring that water, along with the body's salt, to the surface of the skin as sweat. Once on the surface, the water evaporates.