Stopping this medication too soon could cause your infection to come back, or lead to the development of antibiotic-resistant bacteria. The usual dose of Cipro XR for an uncomplicated urinary tract infection (UTI) is 500 mg once a day for three days.The usual dosage for a complicated UTI is Cipro XR 1000 mg once daily for 7 to 14 days. However, people with kidney disease may be given Cipro XR 500 mg once daily, even for a complicated UTI.he recommended dose for a kidney infection (also called pyelonephritis) is 1000 mg once day for 7 to 14 days. However, people with kidney disease may be given 500 mg once daily.