Cellulitis in the lower leg is characterized by signs and symptoms similar to those of a deep vein thrombosis, such as warmth, pain, and swelling (inflammation). This reddened skin or rash may signal a deeper, more serious infection of the inner layers of skin.n contrast to cellulitis, erysipelas is a bacterial infection involving the more superficial layers of the skin, presents with an area of redness with well-defined edges, and more often is associated with fever. More serious infections such as an underlying bone infection or necrotizing fasciitis should be ruled out.