The initial dosages for prednisone will vary from prednisone 5 mg to prednisone 60 mg, depending on the ailment or affliction for which it is prescribed. Some of the usual conditions include arthritis, Crohn's Disease, lupus, and severe allergic reactions of the skin.ebbie. I have been on 20 mg. of prednisone everyday for the last few years. I have been on prednisone a smaller dose everyday for the ast 20 YEARS. My new Dr, just started a 5 mg decress daily I can not even tell you how bad the pain is I feel so sick. Has anyone else been on his for that amount of time.