Q. I’ve been taking levothyroxine for years and have felt crappy the whole time. I could barely drag myself out of bed. Trying to take my thyroid medicine on an empty stomach and wait an hour before eating or drinking was really inconvenient.After reading on your website that thyroid could be taken at night I feel liberated. My days are normal again.hanged the pill to a natural thyroid medication. No more pain, can actually get out of bed in the morning, that was very painful on the old pill. My Dr. can prescribe a compounding medication or the Synthroid. I opted for the compounding pill.