In addition, Lamictal is commonly prescribed to adults with bipolar disorder (manic depression) to delay episodes of depression and mania. (Mania is defined as frenzied or abnormally excited moods). Lamictal is also prescribed off-label to treat clinical depression and migraine headaches. The FDA first approved Lamictal in 1994 as an anti-seizure medication. Approval to use the drug in the treatment of bipolar disorder was given in 2003.