How do Sudafed sinus pressure and pain tablets work? Sudafed sinus pressure and pain tablets contain two active ingredients, the painkiller ibuprofen (200mg) and a decongestant called pseudoephedrine hydrochloride (30mg). Ibuprofen is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID). It relieves mild to moderate pain, inflammation and fever.