When certain heart disease or circulatory system malfunction occurs, it can lead to the problems with the body’s metabolism. The most common heart disease is coronary artery disease (medically called arteriosclerosis) and it is a condition when the plaque forms in the walls of the arteries.eart disease is the general term for all diseases and disorders that affect the heart and blood vessels, such as heart attack, stroke, coronary artery disease, and congenital or present at birth heart defects, as well as arrhythmia, angina and cardiomyopathy. Heart disease affects the body in several ways.