Pain control in pancreatic cancer. Pain can be a major problem for people with pancreatic cancer, especially the exocrine type. These cancers can invade and press on nerves near the pancreas, which can cause pain in the abdomen (belly) or back. Treatment is available to help relieve this pain.ain control in pancreatic cancer. Pain can be a major problem for people with pancreatic cancer, especially the exocrine type. These cancers can invade and press on nerves near the pancreas, which can cause pain in the abdomen (belly) or back. Treatment is available to help relieve this pain.