In a 5-shot revolver, it is an excellent hunting weapon against midsized game, or as a backup when hunting dangerous game. There are other modern (post-1980) revolver cartridges. Currently the most powerful production handgun round is the .500 Smith and Wesson Magnum.Firing a 350gr JHP bullet, it can exceed 3000 foot-pounds of energy, at nearly 2000fps.The .480 Ruger and .475 Linebaugh also exceed the .454 Casull by a wide margin.n a 5-shot revolver, it is an excellent hunting weapon against midsized game, or as a backup when hunting dangerous game. There are other modern (post-1980) revolver cartridges. Currently the most powerful production handgun round is the .500 Smith and Wesson Magnum.