(United States). The average pay for a Registered Nurse (RN) in Los Angeles, California is $35.83 per hour. The highest paying skills associated with this job are Recovery / Post-Anesthesia Care Unit (PACU), Oncology, Critical Care, Cardiology, and Intensive Care Unit (ICU).United States). The average pay for a Registered Nurse (RN) in Los Angeles, California is $35.83 per hour. The highest paying skills associated with this job are Recovery / Post-Anesthesia Care Unit (PACU), Oncology, Critical Care, Cardiology, and Intensive Care Unit (ICU).