1 The labor costs to frame a home typically run $5 to $10 per square foot. 2  This can fluctuate a bit depending on local labor costs and seasonal rates. 3  It should work out to an average total of $15,000 to $30,000 to frame a building.ypical costs: Framing constitutes 60% to 70% of the total cost of building a house. Labor accounts for the other 30% to 40%. 1  Lumber prices are always fluctuating and can be difficult to predict.