A. To answer your question, beef roasts can be done in a moderately slow oven (325 degrees) and need to be cooked 22-30 minutes per pound, depending on doneness. So for example, a 10 pound beef roast to be done should be cooked approximately 4 hours 10 minutes (at 25 minutes per pound).. To answer your question, beef roasts can be done in a moderately slow oven (325 degrees) and need to be cooked 22-30 minutes per pound, depending on doneness. So for example, a 10 pound beef roast to be done should be cooked approximately 4 hours 10 minutes (at 25 minutes per pound).