Hi and thanks for posting. Rifafour is a 4 drug combination pill to treat tuberculosis. The pill is available in different strengths, noted by the dose of the e component, ethambutol.Dosing is based on weight. If your not sure what your correct dose is, it's good to confirm with your health care provider.i and thanks for posting. Rifafour is a 4 drug combination pill to treat tuberculosis. The pill is available in different strengths, noted by the dose of the e component, ethambutol.