What does Prunella mean, popularity, numerology and more. The name Prunella is of Latin origin. The meaning of Prunella is small plum. It is also of English origin, where its meaning is little plum.runella is generally used as a girl's name. It consists of 8 letters and 3 syllables and is pronounced Pru-ne-lla. In the U.S. in 2014 less than 5 girls were given the name. Less than 5 boys were given the name.