Visualize the Effects of Lupus on the Body. Lupus, also known as systemic lupus erythematosus, is an autoimmune disease that can affect almost any part of the body, especially the skin, blood, joints, kidneys, heart, lungs, and brain.Two common symptoms of lupus are a butterfly-shaped rash on the face and extreme sensitivity to sunlight.Read More.isualize the Effects of Lupus on the Body. Lupus, also known as systemic lupus erythematosus, is an autoimmune disease that can affect almost any part of the body, especially the skin, blood, joints, kidneys, heart, lungs, and brain.