Can gabapentin and hydrocodone be taken together. Gabapentin (Neurontin) and hydrocodone (Vicodin) Drug Interactions. Hydrocodone is a semi synthetic opioid derivative of codeine. Hydrocodone is used orally as an analgesic and antitussive. Gabapentin is a drug used to treat seizures and post herpetic neuralgia. When gabapentin is taken with hydrocodone, interaction between gabapentin and hydrocodone ranges from mild to moderate.