How to Use a Centrifuge. Centrifuges are often used to separate suspensions in liquids. Because of their high rotation rates, centrifuges are delicate and can break easily.However, there are only a few simple rules to remember when using them.ake a counterbalance for the centrifuge tube you want to put in the centrifuge. The masses, not volumes, of the tubes should be as close as possible! Unbalanced tubes may permanently damage the centrifuge.