It depends. Some cars, like Hondas, Subarus and others, require factory specific coolant. And that can be expensive ...to the tune of $25 to $35 a gallon for pre-mixed (coolant plus distilled water) coolant. I own both a Subie and a Honda. The good news in all this is these highly expensive elixirs last for 100K; my Forrester is not due for a coolant flush and fill until 105K.