Lotrisone Description. Lotrisone (clotrimazole and betamethasone dipropionate) cream, 1%/0.05%, contains combinations of clotrimazole, an azole antifungal, and betamethasone dipropionate, a corticosteroid, for topical use. Clotrimazole is an odorless, white crystalline powder, insoluble in water and soluble in ethanol.