· just now. Report Abuse. Smallpox vaccination is still available, but it is not a necessary vaccine for the general public. Given the presumed world-wide eradication of smallpox (except for lab samples), the benefits of vaccination no longer outweigh the risks of the vaccine itself for most people.Smallpox vaccination is done with a live vaccinia virus (not smallpox itself, but a similar virus that provides immunity against smallpox).A small percentage of those vaccinated can develop a diffuse deadly infection (progressive vaccinia), myocarditis, and other adverse events. just now. Report Abuse. Smallpox vaccination is still available, but it is not a necessary vaccine for the general public. Given the presumed world-wide eradication of smallpox (except for lab samples), the benefits of vaccination no longer outweigh the risks of the vaccine itself for most people.