Comfort /com-fort/ [2 sylls.] as a girls' name is of English and Latin origin, and the meaning of Comfort is to strengthen and comfort.omfort is an uncommon given name for females but a very popular last name for all people (#8500 out of 150436, Top 6%). (2000 U.S. Census). Presented below is the baby name popularity of Comfort for girls. Comfort has not made it into the Top 1000 thus far. (2014 Birth Statistics).