Historically, serpents and snakes represent fertility or a creative life force. As snakes shed their skin through sloughing, they are symbols of rebirth, transformation, immortality, and healing. The ouroboros is a symbol of eternity and continual renewal of life.he serpent Hydra is a star constellation representing either the serpent thrown angrily into the sky by Apollo or the Lernaean Hydra as defeated by Heracles for one of his Twelve Labors. The constellation Serpens represents a snake being tamed by Ophiuchus the snake-handler, another constellation.