The circulatory system, or cardiovascular system, is made up of the heart, veins, arteries and capillaries.This system is responsible for carrying oxygen and nutrients to all parts of the body. Heart disease and other circulatory problems are major sources of disability and death.ortic Aneurysm. The aorta is the major blood vessel carrying blood away from the heart. Weakening of the blood vessel wall causes a bulge, called an aneurysm. Large or fast growing aneurysms can rupture, causing significant loss of blood into the abdominal cavity.