Toe numbness is usually due to a lack of blood supply to the toes or nerve damage. Toe numbness can also result from infection, inflammation, trauma, malignancy, and other abnormal processes.Most cases of toe numbness are not due to life-threatening disorders.f you experience toe numbness with loss of bladder or bowel control, paralysis, confusion, weakness in the foot, or slurred speech, call 911 or seek immediate medical attention in an emergency facility. If your foot numbness is persistent, recurrent, or causes you concern, contact a medical professional.