1 Removal of a mole typically costs about $150 to $400. 2  It varies from doctor to doctor and by which technique is used.hat should be included: Additional costs: 1  Depending on the type of mole, the surgeon will use one of two techniques. 2  In the first, the surgeon uses a scalpel to shave the mole off at the level of the skin, then cauterizes the wound or applies a liquid to prevent bleeding.