how long does it take advair to get out of your system after being on it for 3 years(250 twice a day)? I just quit advair and doing other alternative medicines to help me. Advair™ Diskus® (fluticasone propionate and salmeterol) Inhalation Powder contains 2 medicines. The inhaled steroid Flovent® (fluticasone propionate) has a half life of around 5 hours, so it would be totally out of your system in a few days. The inhaled long-acting bronchodilator Serevent® (salmeterol) has a similar half life, so it would be totally out of your system after 5 days.