Sponsored Topics. Florence is a town in Rankin County, Mississippi, United States. As of the 2000 census, the town population was 2,396. It is part of the Jackson Metropolitan Statistical Area. Florence is located at 32°09′14″N 90°07′19″W / 32.153782°N 90.122031°W / 32.153782; -90.122031 (32.153782, -90.122031).