You can purchase an over-the-counter saline solution or make one at home. Most over-the-counter saline nasal sprays are isotonic, which means the solution is the same saline concentration as in your body. Hypertonic saline sprays have a higher concentration of salt than that of bodily tissue. Both types of saline sprays can help clear mucus, according to studies, which helps keep your sinuses healthy and infection-free. Saline sprays also help keep the cilia in your nose healthy.