Squamous-cell carcinoma or squamous-cell cancer (SCC or SqCC) is a cancer of a kind of epithelial cell, the squamous cell.These cells are the main part of the epidermis of the skin, and this cancer is one of the major forms of skin cancer.CC is still sometimes referred to as  epidermoid carcinoma  and  squamous-cell epithelioma , though the use of these terms has decreased. SCC typically initially occurs in the sixth decade of life (the 50s), but is most common in the eighth decade (the 70s). It is twice as prevalent in men as in women.