The Paleozoic Era ended with the largest mass extinction in Earth's history, the Permian–Triassic extinction event. The effects of this catastrophe were so devastating that it took life on land 30 million years into the Mesozoic to recover.Recovery of life in the sea may have been much faster.he Cambrian spans from 541 million years to 485 million years ago and is the first period of the Paleozoic and of the Phanerozoic Eon. The Cambrian sparks a boom in evolution in an event known as the Cambrian Explosion in which the largest number of creatures evolve in the history of Earth during one period.