Pescadero, CA. Sponsored Topics. Pescadero is a census-designated place (CDP) in San Mateo County, California two miles (3 km) east of State Route 1 and Pescadero State Beach. The center of town, on Pescadero Creek Road, is located at latitude 37.255 and longitude 122.38028. The town is 14.4 miles (23.2 km) south of Half Moon Bay.