$448 million. The total estimated cost of illness to the nation for ALS, DMD and MMD combined is $1.07 to $1.37 billion per year. The authors note that this estimate is likely to be very conservative.he total estimated cost of illness to the nation for ALS, DMD and MMD combined is $1.07 to $1.37 billion per year. The authors note that this estimate is likely to be very conservative.