Dose of Naproxen Sodium for Acute Pain For acute pain relief or treatment of painful menstrual periods, the usual naproxen sodium dosing for an adult (over age 18) is 220 mg to 550 mg, twice a day. The maximum recommended daily dosage is 1100 mg per day.o not exceed the recommended over-the-counter doses (one tablet or 220 mg, twice a day), and do not take naproxen sodium for more than ten days, unless your healthcare provider recommends it.