It also depends on any other drugs you take. Be sure to tell your doctor about any prescription drugs, over-thecounter drugs, or herbal medicines you take. Over-the-counter Tylenol (generic acetaminophen) is often the best choice for people with high blood pressure, heart failure, or kidney problems. 1  However, high doses of Tylenol can damage the liver, so take the lowest dose you can to get enough pain relief. 2  Never take more than 4,000 milligrams (mg) a day.