Information Systems (IS) Manager Salary. (United States). Slightly less than two-thirds of Information Systems Managers in the United States are seasoned employees who have more than 10 years of experience in the field.Pay ranges from $48K to $119K per year, and the average comes out to $78K per year.ost Information Systems Managers survey respondents are men (77 percent). Most Information Systems Managers like their work and job satisfaction is high. Participants in PayScale's salary questionnaire provided the particulars of this report.