Encephalomalacia (pronunciation: \in-ˌsef-ə-lō-mə-ˈlā-sh(ē-)ə\; ICD-9: 348.89) refers to cerebral softening or loss of brain tissue or parenchyma. It is most commonly seen in the anterior frontal and temporal lobes. This is one of the most severe complications of brain injury (1,3)