This is normal after a tick bite and does not indicate Lyme disease. However, these signs and symptoms may occur within a month after you've been infected: Rash. From 3 to 30 days after an infected tick bite, an expanding red area might appear that sometimes clears in the center, forming a bull’s-eye pattern. The rash (erythema migrans) expands slowly over days and can spread to 12 inches (30 centimeters) across. It is typically not itchy or painful. Erythema migrans is one of the hallmarks of Lyme disease. Some people develop this rash at more than one place on their bodies.