These block certain cell receptor sites for estradiol. This can help both men and women to reduce problems caused by having too much estrogen. Also, as you lose weight and reduce fat in your diet, your levels of bad estrogen will decline. Your body will have less fat to make more of the bad type of estrogen. It's best to take supplements of natural steroid hormones (testosterone, progesterone, estrogen, pregnenolone, DHEA) in the morning. All hormones peak at 4-5 hours after ingestion, then, within 24 hours, the levels come back down.