You have already attended to the entry in the Startup folder, which for the record is on the All Programs list, on the Start menu. In Windows 8 open Task Manager (Ctrl + Shift + Esc or look in Apps under Windows System), select the Startup tab and if Skype appears on the list right-click the entry and select Disable.In earlier versions of Windows type ‘msconfig’ in Search or Run on the Start menu and click the Startup tab.n Windows 8 open Task Manager (Ctrl + Shift + Esc or look in Apps under Windows System), select the Startup tab and if Skype appears on the list right-click the entry and select Disable.