I can't tell you how long the initial breakout will last, because your skin is not the same as mine. I will say that you should give it the 12 weeks. The manufacturer says it may take up to 12 weeks, so until 12 weeks have passed, you can't reach a real verdict.'m currently using Epiduo which is a mixture of Adapalene (Differin) and Benzoyl Peroxide. My initial breakout started after a week of using the cream and I'm still going through it-and I've been using it for four weeks now. As far as I know this is normal and I heard it can last anything between two and six weeks.