The systemic circulation is the portion of the circulatory system is the network of veins, arteries and blood vessels that transports blood from heart, services the body's cells and then re-enters the heart, the Mayo Clinic noted.n average adult has 5 to 6 quarts (4.7 to 5.6 liters) of blood, which is made up of plasma, red blood cells, white blood cells and platelets. In addition to blood, the circulatory system moves lymph, which is a clear fluid that helps rid the body of unwanted material.