The two classes of antidepressants that can cause or worsen tinnitus are the tri-cyclic antidepressants and the SSRI(Selective Serotonin Re-uptake inhibitors). Trepiline(Amitriptyline)- Tricylic. Prozac(Fluoxetine), Paxil(Paroxtine) and Zoloft(Sertraline)- SSRI.