We hypothesised that curcumin would be effective for the treatment of depressive symptoms in individuals with major depressive disorder. METHODS: In a randomised, double-blind, placebo-controlled study, 56 individuals with major depressive disorder were treated with curcumin (500 mg twice daily) or placebo for 8 weeks.The primary measure was the Inventory of Depressive Symptomatology self-rated version (IDS-SR30).urcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. Lopresti AL(1), Maes M(2), Maker GL(3), Hood SD(4), Drummond PD(5).