Lude is slang for a Quaalude, or a pill containing the sedative methaqualone. An example of a lude is a pill sold under the brand name Mandrax.ža ãža luden heo iherden Ã¾an A¾an-ã¾an. ” Rom'leoden Layamon. S. Brut Origin From middle (“english, lude, noise), clamor Sound From hlÈ³d (“english, hle³d, hlè³d, noise, sound), tumult Disturbance-Dissension *hlÅ«dijÅ (“germanic), hla Hlå-Dija-Dijå *sound¸±from- (“proto indo). european a á lewe to hear