One Sprinkles Cupcakes cupcake contains 459 to 497 calories, according to the Calorie King website. This accounts for 23 to 25 percent of the calories you may consume in a day based on a 2,000-calorie diet. Many of the calories in a Sprinkles Cupcakes cupcake come from carbohydrates. One cupcake contains 53.2 to 62.9 g of this nutrient, or 41 to 48 percent of the 130 g recommended for daily consumption by the Institute of Medicine. A cupcake also contains 3.9 to 6 g of protein.