1 The first year cat vaccination cost will generally be the most expensive year, costing upwards of $120 for the entire year. 2  After the cat’s first year, the costs will usually be around $30 to $50 for the entire year for basic vaccinations.accinations are going to be required on an annual basis to ensure that your cat doesn’t come in contact with any deadly diseases / viruses. 1  The cost of the vet exam itself is all going to vary from $55 to as much as $120 just for the visit.