vacation deals to Port Saint Lucie, FL. The total driving distance from Fort Lauderdale, FL to Port Saint Lucie, FL is 93 miles or 150 kilometers. Your trip begins in Fort Lauderdale, Florida. It ends in Port Saint Lucie, Florida. If you are planning a road trip, you might also want to calculate the total driving time from Fort Lauderdale, FL to Port Saint Lucie, FL so you can see when you'll arrive at your destination.