Each tenderloin usually weighs about 1 to 1-1/4 pounds. Pork is cooked in minutes per pound. So roast a tenderloin at 425 degrees F for 15-20 minutes per pound and grill it over medium coals for 15-25 minutes per pound.The internal temperature should be a minimum of 145 degrees F (the USDA lowered the safe temperature for pork in the summer of 2011).ork is cooked in minutes per pound. So roast a tenderloin at 425 degrees F for 15-20 minutes per pound and grill it over medium coals for 15-25 minutes per pound.