She's 25ft long, 300lbs and it takes 15 people to hold her: Meet Medusa the world's largest snake (and her friends) She weighs more than 300lbs, is 25ft long and it takes 15 people to hold her. Now Medusa is set to slither into the record books as the world's largest snake living in captivity. The massive python, which will be on display at the Edge of Hell haunted house attraction in Kansas City, eats a 40lb animal about once a week but could easily eat something weighing more than 100lbs.