Isanti (pronunciation: /aɪsæntiː/ eye-san-tee) is a city in Isanti County, Minnesota, United States. The population was 5,251 at the 2010 census. Minnesota State Highway 65 serves as a main arterial route in the city. According to the United States Census Bureau, the city has a total area of 2.1 square miles (5.5 km²), all of it land.