Blisters-Topic Overview. Blisters are fluid-filled bumps that look like bubbles on the skin. You may develop a blister on your foot when you wear new shoes that rub against your skin or on your hand when you work in the garden without wearing gloves.Home treatment is often all that is needed for this type of blister.ou may develop a blister on your foot when you wear new shoes that rub against your skin or on your hand when you work in the garden without wearing gloves. Home treatment is often all that is needed for this type of blister.