LSD was first made in 1938. The scientist that made it did so using ergot. Ergot is a fungus that grows on grains, especially rye. The LSD was synthesized and then self-tested.Originally, it was thought that the drug could be used to help with circulation.he scientist that made it did so using ergot. Ergot is a fungus that grows on grains, especially rye. The LSD was synthesized and then self-tested. Originally, it was thought that the drug could be used to help with circulation.