Parkersburg is a city in and the county seat of Wood County, West Virginia, United States. Located at the confluence of the Ohio and Little Kanawha rivers, it is the state's fourth-largest city and the largest city in the Parkersburg– Marietta – Vienna Metropolitan Statistical Area. The population was 31,492 at the 2010 census. Its peak of population was more than 44,000 in 1960.