However, in minority of cases the red blood cells are destroyed due to mechanical damage, external toxins, parasites that enter the cell or immune proteins (complement) that attach to the blood cell and triggers its destruction. This is known as intravascular hemolysis.ore prominent symptoms are seen in cases where there is rapid and massive red blood cell destruction. Signs and symptoms include 1  : Shortness of breath. 2  Easily fatigued. 3  Chest pain. 4  Rapid heart rate. 5  Red to brown or dark yellow color of the urine. 6  Jaundice – yellow discoloration of the skin and eye. 7  Enlarged spleen and/or liver.