In biology, a spore is a unit of asexual reproduction that may be adapted for dispersal and for survival, often for extended periods of time, in unfavorable conditions.By contrast, gametes are units of sexual reproduction. Spores form part of the life cycles of many plants, algae, fungi and protozoa.n common parlance, the difference between a spore and a  gamete  (both together called gonites) is that a spore will germinate and develop into a sporeling, while a gamete needs to combine with another gamete to form a zygote before developing further.