Driving distance from Flagstaff, AZ to Tucson, AZ. The total driving distance from Flagstaff, AZ to Tucson, AZ is 260 miles or 418 kilometers. Your trip begins in Flagstaff, Arizona. It ends in Tucson, Arizona. If you are planning a road trip, you might also want to calculate the total driving time from Flagstaff, AZ to Tucson, AZ so you can see when you'll arrive at your destination.