If you have O+ blood you can donate to anyone who is also Rh + . You can donate to A+ , B+, AB+ and other O+ people.You can't donate whole blood to someone that is O-, because they lack the D antigen, and you have the D antigen on the surface of your red blood cells.ike An O+ donor can give to A+, B+, or AB+, as long as the type, screen, and crossmatch is compatible. If in EXTREME emergencies, you can give O-blood to anyone, but ONLY O-because it lacks any red blood cell surface antigen,and therefore won't cause a hemolytic transfusion reaction. O-people are universal donors.