Confidence votes 68. You can inactivate them, not kill them. They are technically not alive. Think of them more like a substance, a protein to be exact. household bleach will inactivate prions if left in a bleach/water solution for at least 30 minutes. the directions for this are under the prions topic on Wikipedia.rions are not eukaryotic. In fact, prions aren't even alive. They are merely an infectious protein, like a virus or a viroid. A commonly known prion is the mad cow disease.