Roxanne /rox-anne/ [2 sylls.] as a girls' name is pronounced roks-ANN. It is of Persian origin, and the meaning of Roxanne is  dawn .Roxandra is a contemporary blend of Roxane and Alexandra, appropriate since Roxane was the Persian princess Alexander the Great married during his travels of conquest. Roxane is the heroine of Rostand's play Cyrano de Bergerac.oxanne /rox-anne/ [2 sylls.] as a girls' name is pronounced roks-ANN. It is of Persian origin, and the meaning of Roxanne is  dawn .