Medication Summary. Common drugs that induce atrioventricular (AV) block include beta-blockers, calcium channel blockers, antiarrhythmics, and digoxin. Withdrawal of offending drugs is the first treatment for heart block. Patients with block at the level of the atrioventricular node (AVN), in the absence of ischemia, can benefit from sympathomimetic agents or vagolytic agents.