Each of these main type of “strains” can help you for different reasons. Therefore this new section regarding which marijuana strain has the best effect on my illness or condition has been created. Pain Relief – Marijuana as a whole can have a positive effect for pain relief but some strains are better than others. The marijuana strain phenotype that best works for pain of any kind is Indica. Indica normally provides a deeper narcotic sensation than Sativa. You’ll definitely feel a strong body sensation and in many cases will want to rest or sleep. This makes Indica the perfect strain for any type of pain relief.