It is a non-ignorable factor to cause insomnia. 3. Side effects of medications. In order to control some symptoms of kidney failure, they may take some certain medications, such as aspirin, losartan, hypotensive drugs, etc.Insomnia appears as a side effect of these medicines. The treatment of insomnia in end stage renal failure.Immunotherapy ---It has been used in China widely, and have a good reputation from kidney disease patients.t is a non-ignorable factor to cause insomnia. 3. Side effects of medications. In order to control some symptoms of kidney failure, they may take some certain medications, such as aspirin, losartan, hypotensive drugs, etc.