Whitehouse is a city in Smith County, Texas, United States. The city had an estimated population of 7,327 in 2006. It is part of the Tyler, Texas Metropolitan Statistical Area. Whitehouse is located at 32°13′24″N 95°13′3″W / 32.22333°N 95.2175°W / 32.22333; -95.2175 (32.223443, -95.217579). The city is bisected by State Highway 110 and Farm to Market Road 346.