Which organ can be seriously affected by infectious mononucleosis? a. kidney c. heart b. spleen d. liver ANS: D Feedback A The liver can be affected by mononucleosis. B Although the spleen may play a part in fighting mononucleosis, it is the liver that can be affected. C The liver can be affected by mononucleosis. D PTS: 1 11. Unbroken skin and mucus are examples of _____. a.