Antigens are chemicals on the surface of a cell. All cells have these. The immune system checks cells and identifies them as self or non-self. Antibodies are proteins produced by certain lymphocytes in response to a specific antigen.B-lymphocytes and T-lymphocytes produce the antibodies. B-lymphocytes become plasma cells which then generate antibodies. T-lymphocytes attack cells which bear antigens they recognize.one marrow contains tissue that produces lymphocytes. B-lymphocytes (B-cells) mature in the bone marrow. T-lymphocytes (T-cells) mature in the thymus gland. Other blood cells such as monocytes and leukocytes are produced in the bone marrow.