Job Description for PICC Line Nurse. 1  Discuss with patients the risks and purpose of PICC line placement, as well as homecare. 2  Perform IV insertions and maintain catheters. 3  Insert central lines, evaluate placement, and monitor vascular access device (VAD) sites on a daily basis. Discuss with patients the risks and purpose of PICC line placement, as well as homecare. 2  Perform IV insertions and maintain catheters. 3  Insert central lines, evaluate placement, and monitor vascular access device (VAD) sites on a daily basis. 4  Educate nursing staff on PICC line placement.