Most synthetic drugs, such as synthetic marijuana (also known as Spice, K2), bath salts and Ecstasy, are created in laboratories and are made to mimic naturally occurring drugs or provide an alternative that doesn’t cause the same side effects.nfortunately, users of synthetic drugs believe the substances to be harmless. The problem with synthetic drugs such as Spice is that by the time the user is aware of any potential problems, it’s often too late to do anything about it.