The following medical conditions are some of the possible causes of Wrist cold. There are likely to be other possible causes, so ask your doctor about your symptoms. 1  Smoking. 2  Scleroderma. 3  Systemic lupus erythematosus. 4  Dermatomyositis. 5  Polymyositis. 6  Mixed connective tissue disorder. 7  Cold agglutinin disease.