The Manhattan is arguably the most popular drink to use bitters. The flavor of the bitters is very prominent since it is a simple drink. There are many variations on the drink, but Manhattans are commonly made using 2 oz. of whiskey, rye or bourbon, 3/4 oz. of sweet vermouth and 1 dash of bitters. Stir the mixture, pour it into a glass and top it off with a maraschino cherry.