Define the Regulation of Glucocorticoid Secretion Glucocorticoid secretion is mainly controlled by ACTH or adrenocorticotropic hormone from the anterior pituitary gland.In any stress, ACTH secretion increases. It stimulates glucocorticoids. ACTH secretion is controlled by CRF or Corticotropin Releasing Factor from the hypothalamus.lucocorticoid secretion is mainly controlled by ACTH or adrenocorticotropic hormone from the anterior pituitary gland. In any stress, ACTH secretion increases. It stimulates glucocorticoids. ACTH secretion is controlled by CRF or Corticotropin Releasing Factor from the hypothalamus.