Driving distance from LAX to Van Nuys, CA. The total driving distance from LAX to Van Nuys, CA is 25 miles or 40 kilometers. Your trip begins at Los Angeles International Airport in Los Angeles, California. It ends in Van Nuys, California. If you are planning a road trip, you might also want to calculate the total driving time from LAX to Van Nuys, CA so you can see when you'll arrive at your destination.