MCP and PIP joint contractures may interfere with activities of daily living and the nodules can be painful. Occasionally, Dupuytren contracture is associated with plantar fascial thickening (Ledderhose disease), involvement of the penis (Peyronie disease), or involvement of the knuckle pads (Garrod nodes).upuytren contracture is most commonly observed in persons of Northern European descent and affects 4-6% of Caucasians worldwide. Many individuals have bilateral disease (45%); in unilateral cases, the right side is more often affected.