Some of the most common symptoms of hormonal imbalances are: 1. Persistent weight gain. Yes, there are lifestyle, diet and physical activity components to maintaining a healthy weight, but that isn't the end of the story. Many women have underlying hormonal imbalances that make it difficult to maintain a healthy weight. Unaddressed or emerging insulin resistance is one of the most common; small changes in diet — such as eliminating processed foods, sugars and wheat — are steps in the right direction. 2. Belly fat and loss of muscle mass.