Cloderm Cream, 0.1% (clocortolone pivalate) topical is used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis.It is a topical (for the skin) corticosteroid.pply Cloderm Cream 0.1% sparingly to the affected areas three times a day and rub in gently. It is not likely that other drugs you take orally or inject will have an effect on topically applied Cloderm Cream topical. But many drugs can interact with each other.