Repetitive-motion injuries can cause pain in the wrist and hand. Carpal tunnel syndrome is an impingement on the median nerve in the area of the wrist that can cause numbness, tingling, and eventually pain or cramping in the hand. Trauma or injuries such as strains and sprains can also cause wrist pain. De Quervain's disease is an inflammation of the tendons that begins in the thumb and extends to the wrist; this condition is another potential cause of wrist pain. Tumors of the bones or other structures in the hand are a very rare cause of wrist pain. REFERENCE: