1. 1. Four cases of Addison's disease associated with proved histoplasmosis are reported. Three of the patients are alive and in fair health five years, three years and three months, respectively, after the diagnosis of the two diseases had been established.he treatment of hypoadrenalism in these cases does not differ from the treatment of Addison's disease due to other causes. As would be expected, there has been no amelioration of Addison's disease associated with apparent quiescence of the histoplasmosis.