Xavier [xavier]▲ as a boys' name is pronounced ecks-ZAY-vee-er, ZAY-vee-er. It is of Basque origin, and the meaning of Xavier is new house. From Etcheberria. Saint Francis Xavier was a 16th-century Jesuit missionary who took Christianity to the East Indies and Japan. Band leader Xavier Cugat; baseball player Javier Lopez. ASSOCIATED WITH house, saint, 16th century, leader.