Re: Prozac/tired! Yes. i take prozac (fluoxetine). it did make me very tired for the first 6-8 weeks. then all of a sudden i had more energy then i knew what to do with. i take mine in the morning. just cause that is when i remember to take it. have been on 20 mg of prozac for about a month now. I am extremely tired all the time. I have to take daily naps and sometimes 2! I don't have any motivation or energy to do anything. However my mood is much better.