House cleaning service (sometimes called maid service) varies in cost according to frequency of service, condition and size of home. Prices are generally based either on the number of rooms, the square footage or by the hour. A 1,300 square-foot single-story home with seven rooms runs $95-$300. 2  A 2,200 two-story three-bedroom home with nine rooms averages $149-$400. 3  Biweekly cleaning of the same five-room apartment costs $59-$124, the seven-room single-story home runs $79-$150, and the larger nine-room two-story home costs $104-$180.