Frederick County, Maryland. Frederick County is a county located in the northern part of the U.S. state of Maryland. As of the 2010 U.S. Census, the population was 240,336. The county seat is Frederick. Frederick County is included in the Washington-Arlington-Alexandria, DC-VA-MD-WV Metropolitan Statistical Area. Like other outlying sections of the Washington metropolitan area, Frederick County has experienced a rapid population increase in recent years.