Last reviewed on RxList 6/12/2015. Lupron Injection (leuprolide acetate) is a synthetic gonadotropin-releasing hormone used in men to treat symptoms of prostate cancer, and in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.ell your doctor promptly if regular periods continue after 2 months of treatment with leuprolide. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.