Carol Ann Susi, Voice Behind Big Bang Theory's Mrs. Wolowitz, Dead at 62. Carol Ann Susi, best known as the voice of Howard Wolowitz’s unseen mother on The Big Bang Theory, has died after a short battle with an aggressive cancer, her rep confirmed Tuesday. In addition to the CBS sitcom, the Brooklyn, N.Y., native appeared on countless TV shows during her 40-year career, including Grey’s Anatomy, Ugly Betty, That ’70s Show, Sabrina the Teenage Witch, Just Shoot Me and Seinfeld.