RNA-dependent DNA polymerase. Definition'. noun. A DNA polymerase enzyme that catalyzes the process of reverse transcription. Supplement. This enzyme makes use of RNA molecule as a template for the synthesis of a complementary DNA strand.It is produced by HIV and other retroviruses in order for them to synthesize DNA from their viral RNA.NA-dependent DNA polymerase. Definition'. noun. A DNA polymerase enzyme that catalyzes the process of reverse transcription. Supplement. This enzyme makes use of RNA molecule as a template for the synthesis of a complementary DNA strand.