Abruzzo (. [aˈbruttso]) is a region of Italy, with an area of 10,763 square kms (4,156 sq mi) and a population of 1.3 million. Its western border lies 80 km (50 mi) east of Rome.The region is divided into the four provinces of L'Aquila, Teramo, Pescara, and Chieti. Abruzzo borders the region of Marche to the north, Lazio to the west and south-west, Molise to the south-east, and the Adriatic Sea to the east.aˈbruttso]) is a region of Italy, with an area of 10,763 square kms (4,156 sq mi) and a population of 1.3 million. Its western border lies 80 km (50 mi) east of Rome.