Most often, MDROs spread from patient to patient on the hands of healthcare workers. They can also spread on objects such as medication cart handles, bed rails, bedside tables, IV poles, and catheters (soft tubes placed in the body), to name a few.and washing: This is the single most important way to prevent the spread of MDROs. Healthcare workers are taught to wash their hands with soap and warm water or use an alcohol-based hand sanitizer before and after treating each patient.