Murdoc is a fictional character in the ABC television series MacGyver, played by Michael Des Barres. Murdoc is an assassin working for the Homicide International Trust, an international group of assassins.He appears in a total of nine episodes, being the most frequent antagonist of the series and one of the very few to actually make recurring appearances.urdoc's next appearance in the television series is seven years later; he has resurfaced to take revenge on MacGyver for foiling his plans during their first encounter. Murdoc's revenge scheme not only fails, but once again results in his apparent death.