Once this occurs, you may experience a heavier flow, and more menstrual blood clots. Hormonal changes can be caused by a number of things including menopause, excessive weight loss or gain, or as a result of some medications.In this situation, your doctor may put you on a hormone therapy.ormonal changes as a cause for period blood clots. The menstruation cycle can be affected by fluctuations of the hormones progesterone and estrogen. These hormones control how the body sheds the lining of the uterus.