Lipase is an enzyme made by the pancreas. When you eat, lipase is released into the digestive tract to aid in the breakdown of fats. Lipase also functions to increase cell permeability. Cell permeability allows vital nutrients and wastes to flow across the cell wall.The nutrients nourish the cell.n many instances, the lipase test will be ordered in conjunction with the amylase test. An amylase test is used to diagnose diseases of the pancreas. The results from these tests are typically used to diagnose and monitor specific health conditions, including: 1  acute pancreatitis.