The symptoms of kidney disease may include: 1  Nausea and vomiting. 2  Passing only small amounts of urine. 3  Swelling, particularly of the ankles, and puffiness around the eyes.4  Unpleasant taste in the mouth and urine-like odor to the breath. 5  Persistent fatigue or shortness of breath.6  Loss of appetite.7  Increasingly higher blood pressure.he symptoms of kidney disease may include: 1  Nausea and vomiting. 2  Passing only small amounts of urine. 3  Swelling, particularly of the ankles, and puffiness around the eyes.