1 A proper home air duct cleaning costs anywhere from $400-$1,000, depending on the size of the system to be cleaned, the type of services offered, the regional climate and the level of use the ventilation system gets, the type of materials inside the ductwork and the amount of contaminants (dust, mold, etc.).hat should be included: Additional costs: 1  Cleaning should include: cleaning all of registers, inside the ductwork, the interior of the heating/ventilating system, the furnace fan, and the coils for an air conditioner or heat pump, according to Real-Estate-Agents.com.