Topical antifungal agents are indicated for thrush, diaper dermatitis, and uncomplicated congenital candidiasis in the term infant [19]. Nystatin, the most commonly used topical therapy, is a polyene drug that is not absorbed by the gastrointestinal tract, making it a topical agent in any of the three common formulations: oral suspension, ointment, or powder. The oral suspension is indicated for the treatment of thrush in patients of all ages.