While some calcifications may indicate breast cancer, such as ductal carcinoma in situ (DCIS), most are noncancerous (benign) conditions. Benign causes of breast calcifications include: 1  Previous injury or surgery to the breast (fat necrosis). 2  Skin (dermal) or blood vessel (vascular) calcification. 3  Breast cysts — fluid-filled sacs in your breast that are usually benign. 4  Fibroadenoma — a solid, benign mass most common in young women. 5  Cell secretions or debris.