REPATHA is also to be used in patients with an inherited condition called homozygous familial hypercholesterolemia (HoFH). For these patients, it is approved to be used in addition to diet and other drugs and treatment that lower LDL cholesterol, and only when LDL cholesterol needs to be lowered further. How is this drug used? REPATHA is an injection that is given under the skin in the thigh, abdomen, or upper arm. What are the benefits of this drug? REPATHA lowers LDL cholesterol.