1 Protection begins four to six weeks after the first shot. 2  The CDC has an information sheet about the Hepatitis A vaccine. 3  The Hepatitis B and combined Hepatitis A/B vaccines usually are given in a series of three shots, with the second shot a month after the first, and the third shot six months after the first. For example, at the Cerro Gordo County Department of Public Health in Iowa, there is no consultation fee, and a Hepatitis A vaccination costs $30 to $35 per dose for a total of $60 to $70.