Rating Newest Oldest. Best Answer: In ecophysiology, tolerance limits are the maximum and minimum values of a given variable that individuals can tolerate or 'stand' while maintaining their normal performance (i.e. all their biological functions).E: another biology question! what does it mean by &#39;tolerance limits?&#39;? in biol we are learning about ectotherm, endotherm, osmoconformers, osmoregulators, salinity, osmososis, negative/positive feedback, stimulus, response ....