The two primary drug classes used for BPH are: Alpha-blockers. These drugs relax smooth muscles, especially in the bladder neck and prostate. They include terazosin (Hytrin), doxazosin (Cardura), tamsulosin (Flomax), alfuzosin (Uroxatral), and silodosin (Rapaflo). Alpha-blockers help relieve BPH symptoms, but they do not reduce the size of the prostate.