Zip Code 63801 Area Codes. 63801 is located in the state of Missouri in the Paducah-Cape Girardeau metro area. Zip code 63801 is primarily located in Scott County. Portions of 63801 are also located in Stoddard County. The official postal service name used for 63801 is SIKESTON, Missouri. Portions of the 63801 zip code are contained within or border the city limits of Sikeston, MO, Miner, MO, Morehouse, MO, Blodgett, MO, Vanduser, MO, Diehlstadt, MO, and Canalou, MO. The 63801 area code is 573.