(Answer #2). John Steinbeck's Of Mice and Men ends with the death of Lennie at the hands of his best friend, George. Steinbeck has been preparing us for a tragic end since the beginning of the novel.Lennie's trouble in Weed, his petting of the dead mouse, and his killing of the puppy have foreshadowed his killing of Curley's wife.osted on. (Answer #3). The ending of Steinbeck's Of Mice and Men is in accord with the characteristic naturalism of Steinbeck's novella. Like the poem of Robert Burns from which the title of the work comes, it is an uncaring universe that allows circumstances to occur.