Lucille /lu-cil-le/ [2 sylls.] as a girls' name is pronounced loo-SEEL. It is of French and Latin origin, and the meaning of Lucille is light. Diminutive of Lucy. Lucilla was used by the Romans and revived in the 19th century.Comedienne Lucille Ball.ucille is a very prominent first name for women (#145 out of 4276, Top 3%) but an unusual surname for all people.