PPI's cause Anxiety. HealingWell.com Forum > Diseases & Conditions > GERD - Heartburn > PPI's cause Anxiety. I've never had panic attacks in my life, but since last week i've had 5-6. Everybody struggles with anxiety at certain points in their life's, and some struggle with it every day. PPI's such as Nexium or Controloc( the only ones i've tried ) have caused me anxiety.