Anyone wanting to trade aha insights feel free to do it in this thread. I welcome as many people as are interested to join me here in trading cool bits of insight. Here's one: Why do thiazides and loop diuretics cause hyperglycemia? Because they lower serum [K+], thereby depolarizing the beta-cell and inhibiting insulin secretion. In effect, low serum [K+] has the opposite effect on the ATP-sensitive K-channel that SUR's have. Maybe that's in First Aid, I don't know... It just dawned on me and I thought I would share.