If you have a single coil Strat, Tele, or clone, this is the string you want.  The harmonics, clarity and feel of these strings is beyond explanation.  Do yourself a favor and throw a few bucks towards a set of these before you spend a penny on pickups or anything else on your guitar.  Even the stock pickups on an entry-level Yamaha Pacifica sound like custom shop kit.  FYI: These strings, played into a tube amp, sound simply amazing.

The "feel" of the strings also allow me to go up a size, where I typically use .09s, I can play .10s without any appreciable change in fretting effort.

They retain tone (at least for me) as long as a coated string, but at a MUCH lower cost.

The effect with humbuckers is not as well-defined, since they don't capture the bell-like ring these strings produce as well as single coils will.  I used them on a Les Paul style guitar, and the strings don't have the same magic.  However, I have one dual-humbucker Strat that totally sings with these, so you never know, give it a try.  It's only a few bucks!
If you have a single coil Strat, Tele, or clone, this is the string you want. The harmonics, clarity and feel of these strings is beyond explanation. Do yourself a favor and throw a few bucks towards a set of these before you spend a penny on pickups or anything else on your guitar. Even the stock pickups on an entry-level Yamaha Pacifica sound like custom shop kit. FYI: These strings, played into a tube amp, sound simply amazing. The "feel" of the strings also allow me to go up a size, where I typically use. 09s, I can play. 10s without any appreciable change in fretting effort. They retain tone (at least for me) as long as a coated string, but at a MUCH lower cost. The effect with humbuckers is not as well-defined, since they don't capture the bell-like ring these strings produce as well as single coils will. I used them on a Les Paul style guitar, and the strings don't have the same magic. However, I have one dual-humbucker Strat that totally sings with these, so you never know, give it a try. It's only a few bucks!