ens ▁j unction s ▁within ▁inter cal ated ▁disc s ; ▁and ▁this ▁interaction ▁is ▁dependent ▁on ▁the ▁presence ▁of ▁G SK ▁ 3 - beta ▁ph osph ory lation ▁sites ▁on ▁beta - c aten in . ▁Kno ck ing ▁out ▁emer in ▁significantly ▁alter ed ▁beta - c aten in ▁local ization ▁and ▁the ▁overall ▁inter cal ated ▁disc ▁architecture , ▁which ▁res emble d ▁a ▁dil ated ▁card iom y op ath y ▁phen ot ype . ▁ ▁In ▁animal ▁models ▁of ▁card iac ▁disease , ▁functions ▁of ▁beta - c aten in ▁have ▁been ▁un ve iled . ▁In ▁a ▁gu inea ▁p ig ▁model ▁of ▁a ort ic ▁st en osis ▁and ▁left ▁vent ric ular ▁hy pert ro phy , ▁beta - c aten in ▁was ▁shown ▁to ▁change ▁sub cell ular ▁local ization ▁from ▁inter cal ated ▁disc s ▁to ▁the ▁c yt os ol , ▁despite ▁no ▁change ▁in ▁the ▁overall ▁cell ular ▁abund ance ▁of ▁beta - c aten in . ▁vin cul in ▁showed ▁a ▁similar ▁profile ▁of ▁change . ▁N - c ad her in ▁showed ▁no ▁change , ▁and ▁there ▁was ▁no ▁compens atory ▁up reg ulation ▁of ▁pla k og lo bin ▁at ▁inter cal ated ▁disc s ▁in ▁the ▁absence ▁of ▁beta - c aten in . ▁In ▁a ▁ham ster ▁model ▁of ▁card iom y op ath y ▁and ▁heart ▁failure , ▁cell - cell ▁ad hes ions ▁were ▁irregular ▁and ▁dis organ ized , ▁and ▁expression ▁levels