▁N DM . ▁▁ ▁Disc uss ion / Con clusion : ▁AB CC 8 ▁gene ▁produces ▁S UR 1 ▁protein ▁sub unit ▁that ▁interact s ▁with ▁pan cre atic ▁ATP - sens itive ▁pot ass ium ▁channel . ▁When ▁the ▁channel ▁opens ▁a ▁large ▁amount ▁of ▁ins ul in ▁is ▁released . ▁Mut ations ▁that ▁occur ▁in ▁AB CC 8 ▁are ▁associated ▁with ▁con g ential ▁hyper ins ul in ism ▁and ▁P ND M ▁or ▁T ND M . ▁Pat ients ▁that ▁have ▁mut ations ▁in ▁their ▁pot ass ium ▁channel , ▁improved ▁their ▁gl uc ose ▁levels ▁with ▁sul fony l ure a ▁reg imen ▁and ▁gli ben clam ide ▁showed ▁successful ▁results ▁in ▁man aging ▁gl uc ose ▁levels ▁as ▁well . ▁▁▁ ▁A ▁ 2 0 0 6 ▁study ▁showed ▁that ▁ 9 0 % ▁of ▁patients ▁with ▁a ▁K CN J 1 1 ▁mut ation ▁were ▁able ▁to ▁successfully ▁transition ▁to ▁sul fony l ure a ▁ther apy . ▁ ▁See ▁also ▁▁ ▁Type ▁ 1 ▁Di ab etes ▁ ▁Type ▁ 2 ▁Di ab etes ▁ ▁References ▁ ▁External ▁links ▁▁ ▁Category : Di ab etes ▁Category : Ne on at ology ▁Category : R are ▁dise ases <0x0A> </s> ▁St ▁Nicholas ' s ▁Church ▁in ▁Ber wick ▁Bass ett , ▁W ilt shire , ▁England ▁dates ▁from ▁the ▁early ▁ 1 3 th   century . ▁It ▁is ▁recorded ▁in ▁the ▁National ▁Heritage ▁List ▁for ▁England ▁as ▁a ▁designated ▁Gra de   II * ▁listed ▁building