▁on ▁gene ▁expression , ▁causing ▁~ 3 0 0 ▁gen es ▁to ▁become ▁up reg ulated ▁upon ▁its ▁induction ▁in ▁breast ▁cancer ▁cell ▁lines . ▁H ox A 5 ▁protein ▁trans du ction ▁domain ▁over expression ▁prevents ▁infl amm ation ▁shown ▁by ▁in hib ition ▁of ▁T NF alpha - indu cible ▁mon ocy te ▁binding ▁to ▁H U V EC s . ▁ ▁LIM ▁gen es ▁▁ ▁LIM ▁gen es ▁encode ▁two ▁ 6 0 ▁am ino ▁acid ▁c yst e ine ▁and ▁hist id ine - rich ▁LIM ▁domains ▁and ▁a ▁home od om ain . ▁The ▁LIM ▁domains ▁function ▁in ▁protein - prote in ▁interactions ▁and ▁can ▁bind ▁z inc ▁mole cules . ▁LIM ▁domain ▁prote ins ▁are ▁found ▁in ▁both ▁the ▁c yt os ol ▁and ▁the ▁nucle us . ▁They ▁function ▁in ▁c yt os ke let al ▁rem od eling , ▁at ▁foc al ▁ad hes ion ▁sites , ▁as ▁sc aff olds ▁for ▁protein ▁complex es , ▁and ▁as ▁trans cription ▁factors . ▁ ▁P ax ▁gen es ▁▁ ▁Most ▁P ax ▁gen es ▁contain ▁a ▁home obox ▁and ▁a ▁pa ired ▁domain ▁that ▁also ▁bind s ▁DNA ▁to ▁increase ▁binding ▁specific ity , ▁though ▁some ▁P ax ▁gen es ▁have ▁lost ▁all ▁or ▁part ▁of ▁the ▁home obox ▁sequence . ▁P ax ▁gen es ▁function ▁in ▁emb ry o ▁segment ation , ▁nerv ous ▁system ▁development , ▁generation ▁of ▁the ▁front al ▁eye ▁fields , ▁ske let al ▁development , ▁and ▁formation ▁of ▁face ▁structures