▁dis soci ation ▁of ▁the ▁dim er ▁is ▁a ▁self ▁catal yt ic ▁path ▁from ▁one ▁t aut omer ▁to ▁the ▁other . ▁Pro t ic ▁sol vent s ▁also ▁medi ate ▁the ▁pro ton ▁transfer ▁during ▁the ▁t aut omer isation . ▁ ▁Syn thesis ▁ 2 - P yr one ▁can ▁be ▁obtained ▁by ▁a ▁cycl isation ▁reaction , ▁and ▁converted ▁to ▁ 2 - py rid one ▁via ▁an ▁exchange ▁reaction ▁with ▁am mon ia : ▁ ▁Py rid ine ▁forms ▁an ▁N - ox ide ▁with ▁some ▁ox id ation ▁agents ▁such ▁as ▁hydro gen ▁per ox ide . ▁This ▁py rid ine - N - ox ide ▁under go es ▁a ▁re arr ang ement ▁reaction ▁to ▁ 2 - py rid one ▁in ▁ac etic ▁an h yd ride : ▁ ▁In ▁the ▁Gu ar esch i - Th or pe ▁cond ens ation ▁cy ano ac et am ide ▁react s ▁with ▁a ▁ 1 , 3 - d ik et one ▁to ▁a ▁ 2 - py rid one . ▁The ▁reaction ▁is ▁named ▁after ▁ ▁I cil io ▁Gu ar esch i ▁and ▁J oc ely n ▁Field ▁Thor pe . ▁ ▁Chem ical ▁properties ▁ ▁Catal yt ic ▁activity ▁ 2 - Py rid one ▁catal ys es ▁a ▁variety ▁of ▁pro ton - dependent ▁re actions , ▁for ▁example ▁the ▁am in ol ysis ▁of ▁est ers . ▁ ▁In ▁some ▁cases , ▁mol ten ▁ 2 - py rid one ▁is