▁is ▁divided ▁into ▁five ▁provinces : ▁An con a , ▁As coli ▁Pic eno , ▁F ermo , ▁Mac er ata , ▁P es aro ▁e ▁U rb ino . ▁ ▁References ▁ ▁External ▁links ▁▁▁▁▁ ▁Official ▁Website ▁of ▁the ▁Mar che ▁Regional ▁Council ▁▁ ▁Ph oto ▁gallery ▁made ▁by ▁a ▁UN ES CO ▁photograph er . ▁▁▁ ▁Category : N UT S ▁ 2 ▁statistical ▁regions ▁of ▁the ▁European ▁Union ▁Category : Reg ions ▁of ▁Italy ▁Category : W ine ▁regions ▁of ▁Italy ▁Category : P ic enum <0x0A> </s> ▁Re ceptor - type ▁ty ros ine - prote in ▁ph osph at ase ▁F ▁is ▁an ▁en zym e ▁that ▁in ▁humans ▁is ▁encoded ▁by ▁the ▁P TP R F ▁gene . ▁ ▁The ▁protein ▁encoded ▁by ▁this ▁gene ▁is ▁a ▁member ▁of ▁the ▁protein ▁ty ros ine ▁ph osph at ase ▁( P TP ) ▁family . ▁P TP s ▁are ▁known ▁to ▁be ▁signal ing ▁mole cules ▁that ▁reg ulate ▁a ▁variety ▁of ▁cell ular ▁processes ▁including ▁cell ▁growth , ▁different iation , ▁mit otic ▁cycle , ▁and ▁on c ogen ic ▁transformation . ▁This ▁P TP ▁poss esses ▁an ▁ext rac ell ular ▁region , ▁a ▁single ▁transm emb rane ▁region , ▁and ▁two ▁tan dem ▁int racy top las mic ▁catal yt ic ▁domains , ▁and ▁thus ▁represents ▁a ▁re ceptor - type ▁P TP . ▁The ▁ext rac ell ular ▁region ▁contains ▁three ▁Ig - like ▁domains , ▁and ▁nine ▁non - Ig ▁like ▁domains ▁similar