▁due ▁to ▁high ▁levels ▁of ▁asym metric ▁dim eth yl argin ine , ▁which ▁inter f ere ▁with ▁the ▁normal ▁L - argin ine - st im ulated ▁nit ric ▁ox ide ▁synth esis ▁and ▁so ▁leads ▁to ▁hy pert ension . ▁The ▁most ▁prev ail ing ▁mechanism ▁of ▁end oth el ial ▁d ys function ▁is ▁an ▁increase ▁in ▁re active ▁o xygen ▁species , ▁which ▁can ▁imp air ▁nit ric ▁ox ide ▁production ▁and ▁activity ▁via ▁several ▁mechan isms . ▁The ▁sign alling ▁protein ▁ER K 5 ▁is ▁essential ▁for ▁maintain ing ▁normal ▁end oth el ial ▁cell ▁function . ▁A ▁further ▁consequence ▁of ▁damage ▁to ▁the ▁end oth el ium ▁is ▁the ▁release ▁of ▁path ological ▁quantities ▁of ▁von ▁Wille brand ▁factor , ▁which ▁promote ▁plate let ▁aggreg ation ▁and ▁ad hes ion ▁to ▁the ▁sub end oth el ium , ▁and ▁thus ▁the ▁formation ▁of ▁potentially ▁fatal ▁th rom bi . ▁ ▁Research ▁ ▁In ▁cancer ▁ther apy ▁the ▁development ▁and ▁delivery ▁of ▁anti - ang i ogen ic ▁dru gs ▁is ▁a ▁very ▁prom ising ▁path ▁and ▁rest oring ▁v asc ular ▁home ost asis ▁holds ▁great ▁potential ▁for ▁the ▁treatment ▁of ▁is chem ic ▁t issue ▁dise ases ▁▁ ▁In ▁April ▁ 2 0 2 0 , ▁the ▁presence ▁of ▁vir al ▁elements ▁in ▁end oth el ial ▁cells ▁of ▁ 3 ▁patients ▁who ▁had ▁died ▁of ▁Cor on av irus ▁disease ▁ 2 0 1 9 ▁was ▁reported ▁for ▁the ▁first ▁time . ▁The ▁research ers