▁cell ▁lines , ▁potentially ▁pointing ▁to ▁a ▁connection ▁with ▁the ▁T G F - β ▁signal ing ▁path way , ▁which ▁is ▁also ▁imp licated ▁in ▁gen etic ▁pre dis position ▁to ▁mig ra ines ▁and ▁has ▁a ▁key ▁role ▁in ▁Mar fan ▁and ▁Lo e ys - D iet z ▁synd rom es , ▁two ▁inherited ▁connect ive ▁t issue ▁dis orders ▁causing ▁a ort ic ▁dis section . ▁ ▁In ▁humans , ▁gen ome - wide ▁association ▁studies ▁have ▁linked ▁P HA CT R 1 ▁to ▁coron ary ▁ar tery ▁disease . ▁Consider ing ▁that ▁ar ter ial ▁calc ification ▁is ▁a ▁well - known ▁risk ▁factor ▁for ▁coron ary ▁ar tery ▁disease ▁and ▁my oc ard ial ▁inf ar ction , ▁one ▁study ▁tested ▁ ∼ 2 . 5 ▁million ▁SN P s ▁for ▁an ▁association ▁with ▁coron ary ▁ar tery ▁calc ification ▁and ▁a ort ic ▁calc ification ▁in ▁ 2 6 2 0 ▁male ▁individuals ▁who ▁were ▁current ▁or ▁former ▁heavy ▁sm ok ers ▁and ▁under w ent ▁ch est ▁CT ▁sc ans ▁in ▁the ▁N EL SON ▁trial . ▁No ▁SN P s ▁were ▁associated ▁with ▁a ort ic ▁calc ification ▁on ▁a ▁gen ome - wide ▁scale . ▁The ▁ 9 p 2 1 ▁loc us ▁was ▁significantly ▁associated ▁with ▁coron ary ▁ar tery ▁calc ification ▁( rs 1 5 3 7 3 7 0 ). ▁Sub sequently , ▁two ▁lo ci ▁at ▁AD AM TS 7 ▁( rs 3 8 2 5 8 0 7