▁application ▁has ▁decl ined ▁since ▁the ▁ 1 9 7 0 s ▁due ▁to ▁environmental ▁reg ulations ▁( see ▁below ). ▁ ▁Po ison ous ▁b rom om eth ane ▁was ▁widely ▁used ▁as ▁p estic ide ▁to ▁f um ig ate ▁soil ▁and ▁to ▁f um ig ate ▁housing , ▁by ▁the ▁tent ing ▁method . ▁Eth yl ene ▁b rom ide ▁was ▁similarly ▁used . ▁These ▁vol atile ▁organ ob rom ine ▁comp ounds ▁are ▁all ▁now ▁reg ulated ▁as ▁o zone ▁de ple tion ▁agents . ▁The ▁Montreal ▁Pro tocol ▁on ▁Sub st ances ▁that ▁De ple te ▁the ▁O zone ▁L ayer ▁scheduled ▁the ▁phase ▁out ▁for ▁the ▁o zone ▁de ple ting ▁chemical ▁by ▁ 2 0 0 5 , ▁and ▁organ ob rom ide ▁p estic ides ▁are ▁no ▁longer ▁used ▁( in ▁housing ▁f um ig ation ▁they ▁have ▁been ▁replaced ▁by ▁such ▁comp ounds ▁as ▁sul f ury l ▁flu or ide , ▁which ▁contain ▁neither ▁the ▁ch lor ine ▁or ▁b rom ine ▁organ ics ▁which ▁harm ▁o zone ). ▁Before ▁the ▁Montreal ▁protocol ▁in ▁ 1 9 9 1 ▁( for ▁example ) ▁an ▁estimated ▁ 3 5 , 0 0 0 ▁t onnes ▁of ▁the ▁chemical ▁were ▁used ▁to ▁control ▁n emat odes , ▁fung i , ▁we eds ▁and ▁other ▁soil - bor ne ▁dise ases . ▁ ▁In ▁ph arm ac ology , ▁in organ ic ▁b rom ide ▁comp ounds , ▁especially ▁pot ass ium ▁b rom ide ,