▁C ax can es ▁in ▁ 1 5 4 1 . ▁Sub du ing ▁the ▁ind igen ous ▁pe op les ▁proved ▁difficult ▁in ▁general ▁due ▁to ▁a ▁lack ▁of ▁large ▁domin ion ▁to ▁co - opt ▁as ▁was ▁done ▁in ▁the ▁Mexico ▁City ▁area . ▁In ▁the ▁early ▁colonial ▁period , ▁it ▁was ▁not ▁certain ▁that ▁the ▁Spanish ▁could ▁imp ose ▁its ▁language ▁or ▁culture ▁onto ▁the ▁native ▁population . ▁The ▁initial ▁effect ▁of ▁colon ization ▁was ▁the ▁influence ▁of ▁N ahu at l , ▁as ▁mest iz os ▁and ▁ind igen ous ▁from ▁central ▁Mexico ▁had ▁a ▁greater ▁impact ▁on ▁the ▁local ▁populations ▁than ▁the ▁sparse ▁Spanish . ▁ ▁The ▁most ▁significant ▁early ▁revol t ▁was ▁the ▁Mi xt ón ▁Reb ell ion ▁in ▁ 1 5 4 1 . ▁United ▁under ▁a ▁leader ▁named ▁Ten ama xt li , ▁the ▁ind igen ous ▁of ▁the ▁J alis co ▁area ▁laid ▁sie ge ▁to ▁Gu adal aj ara . ▁The ▁Spanish ▁provincial ▁government ▁under ▁O ñ ate ▁could ▁not ▁with stand ▁the ▁assault ▁and ▁Pedro ▁de ▁Al var ado ▁was ▁sent ▁to ▁area ▁from ▁Mexico ▁City ▁but ▁this ▁initial ▁attempt ▁was ▁th wart ed . ▁During ▁a ▁battle , ▁a ▁horse ▁fell ▁on ▁Al var ado , ▁mort ally ▁w ounding ▁him . ▁Vic ero y ▁M endo za ▁then ▁arrived ▁with ▁a ▁force ▁of ▁ 3 0 0 ▁hors emen , ▁ 3 0 0 ▁inf antry , ▁art illery ▁and ▁ 2 0 , 0 0 0 ▁T lax