um ▁concentr ations ▁are ▁reached , ▁on ▁average , ▁after ▁three ▁days ▁(" G an ire li x ▁ac et ate ▁injection ," ▁ 2 0 0 9 ). ▁A ▁study ▁admin ister ing ▁gan ire li x ▁to ▁health y ▁adult ▁females ▁( n = 1 5 ) ▁found ▁the ▁mean ▁( SD ) ▁elim ination ▁half - life ▁( t 1 / 2 ) ▁to ▁be ▁ 1 6 . 2 ( 1 . 6 ) ▁hours , ▁volume ▁of ▁distribution / absolute ▁bio av ail ability ▁( V d / F ) ▁ 7 6 . 5 ( 1 0 . 3 ) ▁lit ers , ▁maximum ▁ser um ▁concentration ▁( C max ) ▁ 1 1 . 2 ( 2 . 4 ) ▁ng / m L , ▁and ▁the ▁time ▁until ▁maximum ▁concentration ▁( t max ) ▁ 1 . 1 ( 0 . 2 ) ▁hours . ▁One ▁ 2 5 0   µ g ▁injection ▁of ▁gan ire li x ▁resulted ▁in ▁a ▁mean ▁absolute ▁bio av ail ability ▁of ▁ 9 1 . 1 %. ▁ ▁Chem istry ▁Gan ire li x ▁is ▁derived ▁from ▁G n R H , ▁with ▁am ino ▁acid ▁substitution s ▁made ▁at ▁positions ▁ 1 , ▁ 2 , ▁ 3 , ▁ 6 , ▁ 8 , ▁and ▁ 1 0 . ▁ ▁History ▁The ▁European ▁Commission ▁gave ▁market ing ▁authorization ▁for ▁gan ire li x ▁throughout ▁the ▁European ▁Union ▁to ▁N . V . ▁Organ on ▁in