olog ous ▁recom bin ation . ▁ ▁COL 1 7 A 1 ▁is ▁col lagen . ▁Specifically ▁type ▁XVII , ▁alpha ▁ 1 . ▁This ▁may ▁play ▁a ▁role ▁in ▁overall ▁protein ▁structure . ▁ ▁PR DM 1 6 ▁bind s ▁to ▁DNA ▁and ▁acts ▁as ▁a ▁trans cription al ▁reg ulator . ▁It ▁functions ▁in ▁the ▁different iation ▁between ▁white ▁and ▁brown ▁ad ip ose ▁t issue . ▁It ▁can ▁also ▁be ▁a ▁repr essor ▁of ▁transform ing ▁growth ▁factor - beta ▁signal ing . ▁ ▁Hom ology ▁and ▁evolution ▁ ▁There ▁are ▁no ▁known ▁par al ogs . ▁ ▁There ▁are ▁around ▁ 1 0 0 + ▁known ▁orth olog s ▁which ▁range ▁from ▁prim ates ▁to ▁small ▁ground ▁animals . ▁From ▁these ▁investig ations ▁and ▁that ▁of ▁sequence ▁similarity , ▁an ▁orth olog ▁space ▁can ▁be ▁discussed . ▁The ▁closest ▁relatives ▁to ▁humans ▁with ▁the ▁SM IM 2 3 ▁gene ▁were ▁in ▁prim ates ▁so ▁two ▁types ▁of ▁mon keys ▁were ▁picked ▁which ▁diver ged ▁around ▁ 2 9 . 4 ▁million ▁years ▁ago ▁and ▁had ▁sequence ▁similar ities ▁in ▁the ▁high ▁ 7 0 s . ▁S light ly ▁more ▁distant ▁relatives ▁with ▁the ▁gene ▁come ▁from ▁a ▁wide ▁variety ▁of ▁animals ▁from ▁horses , ▁to ▁sea ▁m amm als , ▁to ▁b ats , ▁and ▁more ▁which ▁all ▁have ▁similar ities ▁between ▁ 6 2 - 6 9 %. ▁Last ly , ▁some ▁dist antly ▁related ▁orth olog s ▁were ▁included ▁like ▁the ▁Tas man ian ▁devil ▁and