, ▁indirect ▁role ▁in ▁ang i ogen esis ▁by ▁prom oting ▁V EG F ▁mobil ization ▁and ▁generating ▁anti ang i ogen ic ▁factors . ▁ ▁For ▁instance , ▁when ▁studying ▁car cin ogen esis ▁of ▁pan cre atic ▁is lets ▁in ▁trans gen ic ▁m ice , ▁Ber gers ▁et ▁al . ▁showed ▁that ▁M MP - 2 ▁and ▁M MP - 9 ▁were ▁up reg ulated ▁in ▁ang i ogen ic ▁les ions ▁and ▁that ▁the ▁up reg ulation ▁of ▁these ▁M MP s ▁triggered ▁the ▁release ▁of ▁bio active ▁V EG F , ▁a ▁pot ent ▁stim ulator ▁of ▁ang i ogen esis . ▁Additionally , ▁the ▁group ▁determined ▁that ▁M MP - 2 ▁knock out ▁m ice ▁showed ▁decre ased ▁rates ▁of ▁tum or ▁growth ▁relative ▁to ▁tum or ▁growth ▁rates ▁in ▁wild ▁type ▁m ice . ▁Furthermore , ▁increased ▁expression ▁and ▁activity ▁of ▁M MP - 2 ▁has ▁been ▁tied ▁to ▁increased ▁v asc ular ization ▁of ▁lung ▁car cin oma ▁met ast ases ▁in ▁the ▁central ▁nerv ous ▁system , ▁which ▁likely ▁increases ▁surv ival ▁rate ▁of ▁these ▁met ast ases . ▁ ▁Finally , ▁M MP - 2 ▁has ▁been ▁also ▁shown ▁to ▁drive ▁l ym ph ang i ogen esis , ▁which ▁is ▁often ▁excess ive ▁in ▁tum or ▁environments ▁and ▁can ▁provide ▁a ▁route ▁of ▁met ast asis ▁for ▁cancer ▁cells . ▁Det ry , ▁et ▁al . ▁showed ▁that ▁knock ing ▁down ▁m mp 2 ▁in ▁z eb raf ish ▁prevent ed ▁the