▁chem other ape ut ic ▁and ▁radiation ▁ther ap ies . ▁which ▁otherwise ▁indu ce ▁apo pt osis ▁of ▁the ▁cells . ▁S 1 P ▁has ▁protected ▁o var ian ▁t issue ▁x en og raft s ▁in ▁SC ID ▁mouse ▁models ▁from ▁radiation ▁induced ▁at res ia . ▁ ▁In ▁animal ▁models ▁these ▁protected ▁o ocy tes ▁have ▁been ▁used ▁to ▁produce ▁health y ▁live ▁young . ▁ ▁Rad i other ap ies ▁and ▁chem other ap ies ▁can ▁cause ▁apo pt osis ▁of ▁o var ian ▁fol lic les , ▁causing ▁prem ature ▁o var ian ▁failure , ▁and ▁so ▁S 1 P ▁is ▁of ▁great ▁interest ▁in ▁fert ility ▁pres ervation . ▁However , ▁its ▁mechanism ▁of ▁in hib iting ▁the ▁s ph ing omy elin ▁apo pt otic ▁path way ▁may ▁also ▁inter f ere ▁with ▁the ▁apo pt osis ▁action ▁of ▁chem other apy ▁dru gs . ▁ ▁Due ▁to ▁the ▁hyper pro l ifer ative ▁action ▁against ▁e pid erm al ▁cells , ▁S 1 P ▁has ▁been ▁considered ▁as ▁an ▁active ▁ph arma ce ut ical ▁ing red ient ▁for ▁hyper pro l ifer ative ▁skin ▁dise ases , ▁in ▁particular , ▁ps or ias is ▁vul gar is ▁and ▁ac ne ▁vul gar is . ▁ ▁Although ▁S 1 P ▁is ▁active ▁at ▁very ▁low ▁concentr ations , ▁bio av ail ability ▁of ▁the ▁comp ound ▁in ▁human ▁skin ▁is ▁a ▁concern . ▁Therefore , ▁a ▁top ical ▁form ulation ▁based ▁on ▁specific ▁drug ▁carri