and ed ▁DNA ▁genom es ▁up ▁to ▁ 2 2 0 ▁kil ob ases ▁long ▁and ▁can ▁code ▁for ▁about ▁ 2 1 1 ▁prote ins . ▁The ▁caps id ▁of ▁this ▁vir ion ▁is ▁ icos ah ed ral ▁sh aped ▁and ▁can ▁be ▁up ▁to ▁ 3 5 0   nm ▁wide . ▁The ▁rep lication ▁cycle ▁of ▁this ▁virus ▁begins ▁in ▁the ▁nucle us ▁of ▁the ▁host ▁and ▁end ▁in ▁the ▁cy top las m . ▁Some ▁vir uses ▁of ▁this ▁family ▁are ▁often ▁found ▁inf ect ing ▁am ph ib ians ▁while ▁other ▁are ▁found ▁in ▁insect ▁and ▁cr ust ace ans . ▁ ▁Marse ille vir idae ▁The ▁Marse ille vir idae ▁vir uses ▁have ▁double ▁str and ed ▁DNA ▁genom es ▁that ▁are ▁about ▁ 3 7 2 ▁kil ob ases ▁long . ▁M embers ▁of ▁the ▁family ▁can ▁have ▁about ▁ 4 5 7 ▁open ▁reading ▁frames ▁( OR F s ) ▁in ▁its ▁gen ome . ▁The ▁host ▁organ isms ▁are ▁am o eb ae . ▁Once ▁it ▁inf ect s , ▁vir al ▁rep lication ▁takes ▁place ▁in ▁the ▁cy top las m . ▁It ▁was ▁found ▁that ▁the ▁gen ome ▁of ▁the ▁family ▁Marse ille vir idae ▁codes ▁for ▁about ▁ 2 8 ▁different ▁prote ins .   The ▁caps id ▁of ▁the ▁mar se ille vir us ▁is ▁about ▁ 2 5 0   nm ▁wide ▁with ▁a ▁geometry ▁shape ▁of ▁an ▁ icos ah ed ral . ▁The ▁rep lication ▁of