▁a ▁qu in one ▁m eth ide ▁with ▁a ▁lab ile ▁hydro gen ▁adjacent ▁to ▁this ▁re active ▁chrom oph ore . ▁K up chan ▁demonstrated ▁that ▁tax od one ▁a rom at izes ▁to ▁a ▁c ate ch ol ▁k et one ▁upon ▁expos ure ▁to ▁m ild ▁acid . ▁Air ▁ox id ation ▁of ▁this ▁c ate ch ol ▁k et one ▁aff ords ▁tax od ione . ▁ ▁Syn thesis ▁Tax od one ▁re arr anges ▁easily ▁in ▁the ▁presence ▁of ▁m ild ▁ac ids ▁and ▁react s ▁readily ▁with ▁nucle oph iles . ▁Although ▁tax od one ▁shows ▁higher ▁ant ican cer ▁and ▁ant ib acter ial ▁activity ▁than ▁tax od ione ▁it ▁el ud ed ▁creation ▁in ▁the ▁labor atory ▁for ▁over ▁ 2 5 ▁years ▁because ▁of ▁its ▁inher ent ▁inst ability . ▁During ▁this ▁time ▁several ▁different ▁groups ▁reported ▁synth eses ▁of ▁the ▁more ▁stable ▁tax od ione . ▁▁ ▁In ▁ 1 9 9 3 ▁tax od one ▁was ▁synth es ized ▁for ▁the ▁first ▁time ▁in ▁a ▁ 1 6 ▁step ▁sequence ▁util izing ▁a ▁unique ▁phen ol ▁ben zy lic ▁epo x ide ▁electron ▁re organ ization ▁in ▁the ▁final ▁step . ▁As ▁tax od one ▁readily ▁decom poses ▁into ▁tax od ione ▁this ▁synth esis ▁of ▁tax od one ▁also ▁constit utes ▁a ▁formal ▁synth esis ▁of ▁tax od ione ▁as ▁well . ▁ ▁Since ▁the ▁synth esis ▁of ▁tax od one ▁there ▁have ▁been ▁additional ▁synth eses ▁of ▁tax od ione