clo prop ane ▁was ▁discovered ▁in ▁ 1 8 8 1 ▁by ▁August ▁Freund , ▁who ▁also ▁proposed ▁the ▁correct ▁structure ▁for ▁the ▁subst ance ▁in ▁his ▁first ▁paper . ▁Freund ▁treated ▁ 1 , 3 - d ib rom op rop ane ▁with ▁sod ium , ▁causing ▁an ▁intr am ole cular ▁W urt z ▁reaction ▁leading ▁directly ▁to ▁cy clo prop ane . ▁The ▁yield ▁of ▁the ▁reaction ▁was ▁improved ▁by ▁Gustav son ▁in ▁ 1 8 8 7 ▁with ▁the ▁use ▁of ▁z inc ▁instead ▁of ▁sod ium . ▁Cy clo prop ane ▁had ▁no ▁commercial ▁application ▁until ▁Hend erson ▁and ▁Lucas ▁discovered ▁its ▁an a est h etic ▁properties ▁in ▁ 1 9 2 9 ; ▁industrial ▁production ▁had ▁begun ▁by ▁ 1 9 3 6 . ▁ ▁Ana est hes ia ▁Cy clo prop ane ▁was ▁introduced ▁into ▁clin ical ▁use ▁by ▁the ▁American ▁an a est het ist ▁Ralph ▁W aters ▁who ▁used ▁a ▁closed ▁system ▁with ▁carbon ▁dio x ide ▁absor ption ▁to ▁con serve ▁this ▁then - cost ly ▁agent . ▁Cy clo prop ane ▁is ▁a ▁relatively ▁pot ent , ▁non - ir rit ating ▁and ▁sweet ▁sm elling ▁agent ▁with ▁a ▁minimum ▁al ve olar ▁concentration ▁of ▁ 1 7 . 5 % ▁and ▁a ▁blood / gas ▁partition ▁coefficient ▁of ▁ 0 . 5 5 . ▁This ▁meant ▁induction ▁of ▁an a est hes ia ▁by ▁in hal ation ▁of ▁cy clo prop ane ▁and ▁o xygen ▁was ▁rapid ▁and ▁not ▁un