▁Syn thesis ▁Cy cl iz ine ▁may ▁be ▁prepared ▁by ▁the ▁E sch we iler – C lar ke ▁m eth yl ation ▁of ▁di phen yl m eth yl pi per azine ▁or ▁by ▁reaction ▁of ▁ben zh yd ry l ▁b rom ide ▁with ▁ 1 - m eth yl pi per azine ▁in ▁ac eton it rile ▁to ▁form ▁the ▁hydro b rom ide ▁salt ▁of ▁the ▁drug . ▁ ▁History ▁Cy cl iz ine ▁was ▁developed ▁in ▁the ▁American ▁division ▁of ▁ph arm acy ▁company ▁B urr ough s ▁Well come ▁( today ▁Gla x o Smith K line ) ▁during ▁a ▁research ▁study ▁involving ▁many ▁dru gs ▁of ▁the ▁anti h ist am ine ▁group . ▁Cy cl iz ine ▁was ▁quickly ▁clin ically ▁found ▁as ▁a ▁pot ent ▁and ▁long - act ing ▁anti em etic . ▁The ▁company ▁named ▁the ▁subst ance ▁– ▁or ▁more ▁precisely ▁cycl iz ine ' s ▁hydro ch lor ide ▁form ▁which ▁it ▁usually ▁appears ▁in ▁– ▁" m are z ine ▁hydro ch lor ide " ▁and ▁started ▁to ▁sell ▁it ▁in ▁the ▁United ▁States ▁under ▁trade ▁name ▁Mare z ine . ▁S elling ▁was ▁begun ▁in ▁France ▁under ▁trade ▁name ▁Mar z ine ▁in ▁ 1 9 6 5 . ▁ ▁The ▁subst ance ▁received ▁more ▁credit ▁when ▁NASA ▁chose ▁it ▁as ▁a ▁space ▁anti em etic ▁for ▁the ▁first ▁occupied ▁moon ▁flight . ▁Cy cl iz ine ▁was ▁introduced ▁to ▁many ▁countries ▁as ▁a ▁common ▁anti em etic