t D NA ▁to ▁the ▁cy top las m , ▁due ▁to ▁the ▁mit och ond rial ▁alter ation ▁and ▁morph ological ▁changes , ▁m t D NA ▁is ▁transferred ▁into ▁the ▁nucle us ▁by ▁one ▁of ▁the ▁various ▁predicted ▁methods ▁and ▁are ▁eventually ▁inserted ▁by ▁double - str and ed ▁break ▁repair ▁processes ▁into ▁the ▁nuclear ▁DNA ▁( n D NA ). ▁Not ▁only ▁has ▁any ▁correlation ▁been ▁found ▁between ▁the ▁fraction ▁of ▁non c oding ▁DNA ▁and ▁NUM T ▁abund ance ▁in ▁the ▁gen ome ▁but ▁NUM T s ▁are ▁also ▁proven ▁to ▁have ▁non - random ▁distribution ▁and ▁a ▁higher ▁lik elihood ▁of ▁being ▁inserted ▁in ▁the ▁certain ▁location ▁of ▁gen ome ▁compare ▁to ▁others . ▁Depending ▁on ▁the ▁location ▁of ▁the ▁insert ion , ▁NUM T s ▁might ▁perturb ▁the ▁function ▁of ▁the ▁gen es . ▁In ▁addition , ▁De ▁nov o ▁integration ▁of ▁NUM T ▁pseud ogen es ▁into ▁the ▁nuclear ▁gen ome ▁has ▁an ▁ad verse ▁effect ▁in ▁some ▁cases , ▁prom oting ▁various ▁dis orders ▁and ▁ag ing . ▁ ▁The ▁first ▁application ▁of ▁the ▁NUM T ▁term ▁in ▁the ▁domestic ▁cat ▁( F el is ▁c atus ) ▁example ▁was ▁striking , ▁since ▁mit och ond rial ▁gene ▁number ▁and ▁content ▁were ▁ampl ified ▁ 3 8 - 7 6 X ▁in ▁the ▁cat ▁nuclear ▁gen ome , ▁besides ▁being ▁trans posed ▁from ▁the ▁cy top las m . ▁The ▁presence ▁of ▁NUM T ▁fragments ▁in ▁the ▁gen ome ▁is ▁not ▁problem atic ▁in ▁all