▁became ▁able ▁to ▁character ize ▁the ▁location ▁of ▁NUM T ▁insert ion ▁precisely . ▁They ▁found ▁out ▁that ▁NUM T ▁fragments ▁tend ▁to ▁be ▁inserted ▁in ▁the ▁regions ▁with ▁high ▁local ▁DNA ▁curv ature ▁or ▁b end ability ▁and ▁high ▁A + T ▁rich ▁o lig om ers , ▁especially ▁T AT . ▁Moreover , ▁NUM T s ▁are ▁mostly ▁inserted ▁into ▁open ▁chrom atin ▁regions . ▁Using ▁the ▁same ▁method , ▁T su ji ▁showed ▁that ▁NUM T s ▁are ▁not ▁usually ▁cluster ed ▁together ▁and ▁the ▁NUM T s ▁produced ▁by ▁D - loop ▁are ▁usually ▁under - re present ed ▁which ▁evident ▁more ▁v ivid ly ▁in ▁mon key ▁and ▁human ▁compare ▁to ▁r ats ▁and ▁mouse ▁due ▁to ▁the ▁total ▁length ▁of ▁their ▁NUM T s . ▁However ▁T su ji ▁also ▁found ▁that ▁retro trans pos on ▁structure ▁is ▁highly ▁en rich ed ▁in ▁NUM T ▁fl anks ▁and ▁most ▁NUM T s ▁are ▁inserted ▁in ▁close ▁proxim ity ▁of ▁retro trans pos on ▁while ▁only ▁a ▁few , ▁ 1 0 ▁out ▁of ▁ 5 5 7 ▁NUM T s , ▁were ▁inserted ▁within ▁a ▁retro trans pos on , ▁they ▁could ▁not ▁find ▁any ▁clear ▁relation ▁the ▁size ▁of ▁non - c oding ▁DNA ▁and ▁the ▁number ▁of ▁NUM T . ▁ ▁Con sequ ences ▁of ▁De ▁Nov o ▁Integr ation ▁of ▁NUM T ▁In ser ts ▁ ▁NUM T s ▁are ▁not ▁utter ly ▁function less ▁and ▁certain ▁functions ▁are ▁being ▁associated ▁with ▁them .