▁early ▁due ▁to ▁lack ▁of ▁satisf actory ▁results . ▁ ▁Comp ounds ▁that ▁had ▁some ▁ne uro prote ct ive ▁effect ▁in ▁in ▁vit ro ▁research ▁but ▁never ▁moved ▁to ▁in ▁v ivo ▁studies ▁include ▁ β - la ct am ▁ant ib iot ics ▁( e . g ., ▁ce ft ri ax one ) ▁and ▁fol list atin . ▁ ▁Mus cle ▁rest oration ▁▁ ▁This ▁approach ▁a ims ▁to ▁counter ▁the ▁effect ▁of ▁S MA ▁by ▁target ing ▁the ▁mus cle ▁t issue ▁instead ▁of ▁neur ons . ▁▁ ▁C K - 2 1 2 7 1 0 7 ▁( CK - 1 0 7 ) ▁is ▁a ▁ske let al ▁tro pon in ▁activ ator ▁developed ▁by ▁Cy to kin et ics ▁in ▁co operation ▁with ▁A stell as . ▁The ▁drug ▁a ims ▁at ▁increasing ▁mus cle ▁react ivity ▁despite ▁lower ed ▁neural ▁sign alling . ▁, ▁the ▁mole c ule ▁is ▁in ▁a ▁phase ▁II ▁clin ical ▁trial ▁in ▁ad oles cent ▁and ▁adult s ▁with ▁S MA ▁types ▁ 2 , ▁ 3 , ▁and ▁ 4 . ▁ ▁St em ▁cells ▁In ▁ 2 0 1 3 – 2 0 1 4 , ▁a ▁small ▁number ▁of ▁S MA 1 ▁children ▁in ▁Italy ▁received ▁court - m and ated ▁stem ▁cell ▁in jections ▁following ▁the ▁St am ina ▁sc am , ▁but ▁the ▁treatment ▁was ▁reported ▁having ▁no ▁effect . ▁ ▁Wh ilst ▁stem ▁cells ▁never ▁form ▁a ▁part ▁of ▁any ▁recogn ised ▁ther apy