▁This ▁has ▁been ▁proven ▁for ▁similar ▁subst ances ▁like ▁flu or ene ▁and ▁flu or anth ene , ▁but ▁has ▁yet ▁to ▁be ▁investig ated ▁for ▁ben zo [ c ] flu or ene . ▁ ▁Met abol ism ▁and ▁ex cret ion ▁Ben zo [ c ] flu or ene ▁is ▁mainly ▁met abol ized ▁by ▁the ▁C Y P ▁en zym es ▁in ▁the ▁li ver . ▁There ▁is ▁also ▁evidence ▁that ▁a ▁larger ▁number ▁of ▁met abol ites ▁are ▁formed ▁in ▁the ▁l ungs , ▁which ▁might ▁explain ▁why ▁ben zo [ c ] flu or ene ▁is ▁such ▁a ▁pot ent ▁lung ▁tum or igen . ▁It ▁is ▁possible ▁that ▁ben zo [ c ] flu or ene ▁may ▁have ▁a ▁unique ▁( and ▁still ▁unknown ) ▁mechanism ▁of ▁activation ▁or ▁transport ation , ▁which ▁explains ▁why ▁the ▁l ungs ▁are ▁target ed . ▁The ▁initial ▁steps ▁of ▁the ▁met abol ism , ▁the ▁phase ▁I ▁bi otr ans formation , ▁are ▁described ▁above . ▁ ▁For ▁many ▁PA H s ▁it ▁has ▁been ▁proven ▁that ▁they ▁are ▁conjug ated , ▁in ▁phase ▁II , ▁with ▁either ▁gl uc ur on ide , ▁sul f ate ▁or ▁gl ut ath ione . ▁More ▁research ▁on ▁this ▁topic ▁is ▁necessary ▁for ▁ben zo [ c ] flu or ene . ▁Gl uc ur on ide ▁and ▁sul f ate ▁conjug ates ▁of ▁PA H ▁met abol ites ▁are ▁generally ▁ex cret ed ▁in ▁the ▁b ile ▁and ▁ur ine .