▁to ▁an ▁al de hy de : ▁ ▁This ▁variation ▁has ▁been ▁applied ▁in ▁the ▁synth esis ▁of ▁novel ▁ind oles : ▁ ▁with ▁cy an ogen ▁b rom ide ▁medi ated ▁py rid ine ▁activation . ▁▁ 2 0 0 7 ▁redis cover y ▁In ▁ 2 0 0 6 ▁and ▁again ▁in ▁ 2 0 0 7 ▁the ▁Z in cke ▁reaction ▁was ▁redis cover ed ▁by ▁a ▁research ▁group ▁from ▁Japan ▁ ▁and ▁a ▁group ▁from ▁the ▁USA . ▁Both ▁groups ▁claimed ▁the ▁synth esis ▁of ▁a ▁ 1 2 ▁member ed ▁dia za ann ul ene ▁( structure ▁ 1 ) ▁from ▁an ▁N - ary l ▁py rid in ium ▁ch lor ide ▁and ▁an ▁am ine , ▁an ▁an il ine ▁in ▁the ▁case ▁of ▁the ▁Japanese ▁group ▁( dep icted ▁below ) ▁and ▁an ▁ali ph atic ▁am ine ▁( antic ip ating ▁sur fact ant ▁properties ) ▁in ▁the ▁case ▁of ▁the ▁American ▁group . ▁ ▁In ▁a ▁letter ▁to ▁An gew and te ▁Chem ie , ▁the ▁German ▁chem ist ▁Man fred ▁Christ l ▁ ▁pointed ▁out ▁not ▁only ▁that ▁the ▁alleg ed ▁new ▁chem istry ▁was ▁in ▁fact ▁ 1 0 0 - year - old ▁Z in cke ▁chem istry ▁but ▁also ▁that ▁the ▁proposed ▁structure ▁for ▁the ▁reaction ▁product ▁was ▁not ▁the ▁ 1 2 ▁member ed ▁ring ▁but ▁the ▁ 6 ▁member ed ▁py rid in ium ▁salt ▁( structure ▁ 2 ). ▁Initial ly ▁both ▁groups ▁conced ed ▁that