▁free ▁test oster one ▁levels ▁suggests ▁that ▁a ▁portion ▁of ▁its ▁weak ▁and ro gen ic ▁effects ▁are ▁medi ated ▁indirect ly ▁by ▁facil it ating ▁the ▁activity ▁of ▁test oster one ▁and ▁di h ydro test oster one ▁through ▁the ▁disp lacement ▁of ▁them ▁from ▁SH B G . ▁In ▁addition ▁to ▁binding ▁to ▁and ▁occup ying ▁SH B G ▁however , ▁dan az ol ▁also ▁decre ases ▁the ▁he p atic ▁production ▁of ▁SH B G ▁and ▁therefore ▁SH B G ▁levels , ▁and ▁so ▁down reg ulation ▁of ▁SH B G ▁may ▁be ▁involved ▁as ▁well . ▁Dan az ol ▁likely ▁decre ases ▁he p atic ▁production ▁of ▁SH B G ▁by ▁reducing ▁est ro gen ic ▁and ▁increasing ▁and ro gen ic ▁activity ▁in ▁the ▁li ver ▁( as ▁and rog ens ▁and ▁est rog ens ▁decrease ▁and ▁increase , ▁respectively , ▁he p atic ▁SH B G ▁synth esis ). ▁In ▁accord ance ▁with ▁the ▁notion ▁that ▁supp ression ▁of ▁SH B G ▁is ▁involved ▁in ▁the ▁and ro gen ic ▁effects ▁of ▁dan az ol , ▁the ▁drug ▁has ▁syn erg istic ▁rather ▁than ▁add itive ▁and ro gen ic ▁effects ▁in ▁combination ▁with ▁test oster one ▁in ▁bio ass ays ▁( which ▁is ▁most ▁likely ▁secondary ▁to ▁the ▁increased ▁free ▁test oster one ▁levels ). ▁ ▁It ▁is ▁not ew orth y ▁that ▁ 2 - h ydro x ym eth yle this ter one , ▁a ▁major ▁met abol ite ▁of ▁dan az ol ,