▁card iac ▁death . ▁Inter cal ated ▁disc ▁architecture ▁was ▁sever ely ▁imp a ired ▁and ▁conne x in ▁ 4 3 - res ident ▁gap ▁j unction s ▁were ▁marked ly ▁reduced . ▁Elect ro card i ogram ▁measurements ▁captured ▁sp ont aneous ▁le th al ▁vent ric ular ▁arr h yth mi as ▁in ▁the ▁double ▁trans gen ic ▁animals , ▁suggesting ▁that ▁the ▁two ▁c aten ins — beta - c aten in ▁and ▁pla k og lo bin ▁are ▁critical ▁and ▁id isp ens ible ▁for ▁me ch ano elect rical ▁coupling ▁in ▁card iom y ocy tes . ▁ ▁C lin ical ▁significance ▁ ▁Ro le ▁in ▁de pression ▁ ▁Whether ▁or ▁not ▁a ▁given ▁individual ' s ▁brain ▁can ▁deal ▁effectively ▁with ▁stress , ▁and ▁thus ▁their ▁sus cept ibility ▁to ▁de pression , ▁depends ▁on ▁the ▁beta - c aten in ▁in ▁each ▁person ' s ▁brain , ▁according ▁to ▁a ▁study ▁conducted ▁at ▁the ▁I c ahn ▁School ▁of ▁Medicine ▁at ▁Mount ▁S ina i ▁and ▁published ▁November ▁ 1 2 , ▁ 2 0 1 4 ▁in ▁the ▁journal ▁Nature . ▁ ▁High er ▁beta - c aten in ▁signal ing ▁increases ▁behavior al ▁flex ibility , ▁whereas ▁defect ive ▁beta - c aten in ▁signal ing ▁leads ▁to ▁de pression ▁and ▁reduced ▁stress ▁management . ▁ ▁Ro le ▁in ▁card iac ▁disease ▁ ▁Alter ed ▁expression ▁profiles ▁in ▁beta - c aten in ▁have ▁been ▁associated ▁with ▁dil ated ▁card iom y op