▁about ▁down stream ▁effects ▁on ▁a ▁number ▁of ▁gen es ▁reg ulating ▁vital ▁cell ▁cycle ▁processes , ▁such ▁as ▁apo pt osis , ▁pro l ifer ation ▁and ▁ang i ogen esis . ▁ ▁mi R - 2 1 4 ▁is ▁also ▁thought ▁to ▁reg ulate ▁type - I ▁col lagen . ▁ ▁Ro le ▁in ▁cancer ▁mi R - 2 1 4 ▁has ▁been ▁found ▁to ▁be ▁down reg ulated ▁in ▁human ▁cer v ical ▁cancer ; ▁when ▁mi R - 2 1 4 ▁was ▁up reg ulated ▁in ▁He La ▁cancer ▁cells , ▁it ▁was ▁found ▁to ▁significantly ▁reduce ▁cell ▁growth . ▁Two ▁m R NA ▁targets ▁were ▁identified ▁as ▁those ▁encoding ▁the ▁prote ins ▁M AP 2 K 3 ▁and ▁M AP K 8 . ▁ ▁The ▁increased ▁expression ▁of ▁mi R - 2 1 4 ▁in ▁pan cre atic ▁cancer ▁could ▁bring ▁about ▁increased ▁resistance ▁to ▁chem other apy . ▁ ▁In ▁human ▁gli oma ▁cell ▁line ▁T 9 8 G ▁expression ▁of ▁mi R - 2 1 4 ▁has ▁been ▁shown ▁to ▁suppress ▁expression ▁of ▁the ▁u bi quit in - con j ug ating ▁en zym e ▁ 9 ▁( U BC 9 ) ▁and ▁reduces ▁tum our ▁cell ▁pro l ifer ation . ▁ ▁The ▁protein ▁U BC 9 ▁is ▁involved ▁in ▁the ▁sum o yl ation ▁path way , ▁and ▁is ▁up - reg ulated ▁in ▁many ▁can cers . ▁ ▁Imp lication ▁of ▁mi R - 2 1 4 ▁in ▁ske let ogen esis