▁cancer ▁cells , ▁and ▁reg ulating ▁their ▁movement ▁and ▁pro l ifer ation ▁of ▁cancer ▁to ▁other ▁parts ▁of ▁the ▁body . ▁ ▁Mechan ism ▁and ▁function ▁▁ ▁Cell ▁spread ing ▁and ▁movement ▁occur ▁through ▁the ▁process ▁of ▁binding ▁of ▁cell ▁surface ▁integr in ▁re cept ors ▁to ▁ext rac ell ular ▁matrix ▁ad hes ion ▁mole cules . ▁Vin cul in ▁is ▁associated ▁with ▁foc al ▁ad hes ion ▁and ▁ad her ens ▁j unction s , ▁which ▁are ▁complex es ▁that ▁nucle ate ▁act in ▁fil aments ▁and ▁cross link ers ▁between ▁the ▁external ▁medium , ▁pl asma ▁memb rane , ▁and ▁act in ▁c yt os ke leton . ▁The ▁complex ▁at ▁the ▁foc al ▁ad hes ions ▁consists ▁of ▁several ▁prote ins ▁such ▁as ▁vin cul in , ▁α - act in in , ▁p ax ill in , ▁and ▁tal in , ▁at ▁the ▁int rac ell ular ▁face ▁of ▁the ▁pl asma ▁memb rane . ▁ ▁In ▁more ▁specific ▁terms , ▁the ▁am ino - ter minus ▁of ▁vin cul in ▁bind s ▁to ▁tal in , ▁which , ▁in ▁turn , ▁bind s ▁to ▁ β - integr ins , ▁and ▁the ▁car box y - ter minus ▁bind s ▁to ▁act in , ▁ph osph ol ip ids , ▁and ▁p ax ill in - form ing ▁hom od im ers . ▁The ▁binding ▁of ▁vin cul in ▁to ▁tal in ▁and ▁act in ▁is ▁reg ulated ▁by ▁poly ph osph o inos it ides