/ th re on ine ▁rich ▁linker ▁region ▁between ▁Ser 2 7 0 ▁to ▁Th r 2 9 4 ▁appear ▁to ▁be ▁regul atory . ▁The ▁p 6 2 ▁complex ▁is ▁local ized ▁to ▁both ▁the ▁nucle op las mic ▁and ▁cy top las mic ▁sides ▁of ▁the ▁p ore ▁complex ▁and ▁the ▁relative ▁diameter ▁of ▁p 6 2 ▁complex ▁relative ▁to ▁the ▁nuclear ▁p ore ▁complex ▁suggests ▁it ▁interact s ▁in ▁p ore ▁g ating . ▁ ▁Function ▁ ▁P 6 2 ▁appears ▁to ▁interact ▁with ▁m R NA ▁during ▁transport ▁out ▁of ▁the ▁nucle us . ▁P 6 2 ▁also ▁interact s ▁with ▁a ▁nuclear ▁transport ▁factor ▁( N TF 2 ) ▁protein ▁that ▁is ▁involved ▁in ▁tra ff ick ing ▁prote ins ▁between ▁cy top las m ▁and ▁nucle us . ▁Another ▁protein , ▁import in ▁( beta ) ▁bind s ▁to ▁the ▁hel ical ▁rod ▁section ▁of ▁p 6 2 , ▁which ▁also ▁bind s ▁N TF 2 ▁suggesting ▁the ▁formation ▁of ▁a ▁higher ▁order ▁g ating ▁complex . ▁K ary opher in ▁beta 2 ▁( transport in ), ▁a ▁rib op rote in ▁trans porter ▁also ▁interact s ▁with ▁p 6 2 . ▁P 6 2 ▁also ▁interact s ▁with ▁N up 9 3 , ▁and ▁when ▁N up 9 8 ▁is ▁de ple ted ▁p 6 2 ▁fails ▁to ▁assemble ▁with ▁nuclear ▁p ore ▁complex es . ▁Mut ant ▁por es ▁could ▁not ▁dock / transport ▁prote ins ▁with ▁nuclear ▁local ization ▁signals ▁or ▁M 9 ▁import