▁the ▁ins ul in ▁do se ▁requirement ▁of ▁T ND M ▁is ▁often ▁lower . ▁T ND M ▁resol ves ▁on ▁its ▁own ▁at ▁an ▁average ▁age ▁of ▁twelve ▁weeks . ▁Although , ▁individuals ▁will ▁re lapse ▁ ▁in ▁ 5 0 % ▁of ▁cases ▁( us ually ▁during ▁child hood ▁or ▁young ▁ad ul th ood ). ▁The ▁parts ▁of ▁the ▁body ▁that ▁are ▁mostly ▁affected ▁are ▁the ▁pan cre as , ▁central ▁nerv ous ▁system ▁and ▁various ▁t issues ▁of ▁the ▁body . ▁ ▁An ▁average ▁of ▁ 7 0 % ▁of ▁T ND M ▁is ▁caused ▁by ▁defect s ▁initi ating ▁over - expression ▁of ▁the ▁father ▁gen es ▁in ▁the ▁im print ed ▁region ▁( gen es ▁whose ▁expression ▁is ▁dependent ▁on ▁the ▁parent ▁that ▁contributed ▁them ) ▁of ▁chrom os ome ▁ 6 q 2 4 ▁( Ch rom os ome ▁meaning ▁a ▁string - like ▁structure ▁made ▁of ▁nucle ic ▁acid ▁and ▁protein ▁that ▁car ries ▁gen etic ▁material ). ▁There ▁are ▁three ▁mechanism ▁that ▁can ▁cause ▁ 6 q 2 4 - related ▁T ND M , ▁which ▁includes ▁the ▁father ' s ▁DNA ▁being ▁defect ed ▁by ▁ ▁un ip ar ental ▁is od is omy ▁( UP D ) ▁on ▁chrom os ome ▁ 6 ▁and ▁inherited ▁dup lication ▁of ▁ 6 q 2 4 ▁( in her ited ▁dup lication ▁is ▁a ▁small ▁chrom os om al ▁change ▁in ▁which ▁a ▁very ▁little ▁amount ▁of ▁gen etic ▁material ▁is ▁copied ▁in ▁chrom os