▁divide ▁until ▁bro ck ▁the ▁cell ▁memb rane . ▁They ▁are ▁released ▁to ▁inf ect ▁new ▁cells ▁as ▁am ast ig otes ▁stage . ▁When ▁an ▁un in fect ed ▁sand ▁fly ▁bit es ▁an ▁inf ected ▁m amm al ▁res er voir , ▁the ▁sand fly ▁ing ests ▁the ▁am ast ig otes , ▁therefore ▁they ▁transform ▁in ▁prom ast ig otes ▁and ▁divide ▁in ▁the ▁mid g ut ▁of ▁the ▁fly , ▁those ▁prom ast ig otes ▁migr ates ▁to ▁the ▁prob os cis ▁and ▁are ▁able ▁to ▁produce ▁Le ish man ias is ▁disease . ▁ ▁There ▁are ▁no ▁blood ▁stages ▁in ▁the ▁life ▁cycle ▁of ▁L . ▁mex icana ▁( un like ▁Mal aria ▁and ▁Try pan os om ias is ). ▁ ▁L . ▁mex icana ▁can ▁indu ce ▁the ▁cut aneous ▁and ▁diff use ▁cut aneous ▁clin ical ▁manifest ations ▁in ▁humans . ▁The ▁cut aneous ▁type ▁develop s ▁an ▁ul cer ▁at ▁the ▁b ite ▁site , ▁here ▁the ▁am ast ig otes ▁do ▁not ▁spread ▁and ▁the ▁ul cers ▁become ▁visible ▁either ▁a ▁few ▁days ▁or ▁several ▁months ▁after ▁the ▁initial ▁b ite . ▁The ▁diff use ▁cut aneous ▁type ▁begins ▁when ▁the ▁am ast ig ote ▁diff uses ▁through ▁the ▁skin ▁and ▁met ast as ize ▁to ▁other ▁t issue . ▁This ▁type ▁does ▁not ▁produce ▁ul cers ▁and ▁there ▁is ▁no ▁treatment . ▁ ▁Tre at ment ▁of ▁Le ish man ias is ▁caused ▁by ▁L . ▁mex icana ▁consists ▁on ▁pent aval