▁set ▁up ▁quar antine ▁sites ▁such ▁as ▁the ▁L azz are tt os ▁of ▁Dub rov nik ▁where ▁arriv ing ▁ship ▁personnel ▁were ▁held ▁for ▁up ▁to ▁ 4 0 ▁days . ▁According ▁to ▁current ▁estimates , ▁the ▁b ub onic ▁pl ague ▁had ▁a ▁ 3 7 - day ▁period ▁from ▁in fection ▁to ▁death ; ▁therefore , ▁the ▁European ▁quar ant ines ▁would ▁have ▁been ▁highly ▁successful ▁in ▁determ ining ▁the ▁health ▁of ▁cre ws ▁from ▁potential ▁trad ing ▁and ▁supply ▁ships . ▁ ▁Other ▁dise ases ▁l ent ▁themselves ▁to ▁the ▁practice ▁of ▁quar antine ▁before ▁and ▁after ▁the ▁dev ast ation ▁of ▁the ▁pl ague . ▁Those ▁aff lic ted ▁with ▁le pro s y ▁were ▁histor ically ▁isolated ▁long - term ▁from ▁society , ▁and ▁attempts ▁were ▁made ▁to ▁check ▁the ▁spread ▁of ▁sy ph ilis ▁in ▁northern ▁Europe ▁after ▁ 1 4 9 2 , ▁the ▁advent ▁of ▁yellow ▁fe ver ▁in ▁Spain ▁at ▁the ▁beginning ▁of ▁the ▁ 1 9 th ▁century , ▁and ▁the ▁arrival ▁of ▁A si atic ▁ch ol era ▁in ▁ 1 8 3 1 . ▁ ▁Ven ice ▁took ▁the ▁lead ▁in ▁measures ▁to ▁check ▁the ▁spread ▁of ▁pl ague , ▁having ▁appointed ▁three ▁guard ians ▁of ▁public ▁health ▁in ▁the ▁first ▁years ▁of ▁the ▁Black ▁Death ▁( 1 3 4 8 ). ▁The ▁next ▁record ▁of ▁prevent ive ▁measures ▁comes ▁from ▁ ▁Reg gio / Mod ena ▁in ▁ 1 3 7 4 . ▁Ven ice ▁founded ▁the ▁first ▁la