ide ▁meaning ▁that ▁it ▁only ▁works ▁on ▁in fe ctions ▁within ▁the ▁int est ines . ▁ ▁D il ox an ide ▁came ▁into ▁medical ▁use ▁in ▁ 1 9 5 6 . ▁It ▁is ▁on ▁the ▁World ▁Health ▁Organ ization ' s ▁List ▁of ▁Ess ential ▁Medic ines , ▁the ▁saf est ▁and ▁most ▁effective ▁medic ines ▁needed ▁in ▁a ▁health ▁system . ▁It ▁is ▁not ▁commer cially ▁available ▁in ▁much ▁of ▁the ▁developed ▁world ▁as ▁of ▁ 2 0 1 2 . ▁ ▁Medical ▁uses ▁ ▁D il ox an ide ▁f uro ate ▁works ▁only ▁in ▁the ▁dig est ive ▁tract ▁and ▁is ▁a ▁l umen al ▁am eb ic ide . ▁It ▁is ▁considered ▁second ▁line ▁treatment ▁for ▁in fection ▁with ▁am o eb as ▁when ▁no ▁sympt oms ▁are ▁present ▁but ▁the ▁person ▁is ▁passing ▁c yst s , ▁in ▁places ▁where ▁in fe ctions ▁are ▁not ▁common . ▁Par om om yc in ▁is ▁considered ▁the ▁first ▁line ▁treatment ▁for ▁these ▁cases . ▁ ▁For ▁people ▁who ▁are ▁sympt om atic , ▁it ▁is ▁used ▁after ▁treatment ▁with ▁amb ec ides ▁that ▁can ▁pen et rate ▁t issue , ▁like ▁met ron id az ole ▁or ▁tin id az ole . ▁D il ox an ide ▁is ▁considered ▁second - line , ▁while ▁par om om yc in ▁is ▁considered ▁first ▁line ▁for ▁this ▁use ▁as ▁well . ▁ ▁Ad verse ▁effects ▁Side ▁effects ▁include ▁flat ul ence , ▁it ch iness , ▁and ▁h ives .