▁impact ▁on ▁on going ▁studies ▁of ▁mit och ond rial ▁heter op las my . ▁ ▁As ▁previously ▁mentioned , ▁m t D NA ▁is ▁inserted ▁into ▁the ▁nuclear ▁gen ome ▁only ▁when ▁a ▁D SB ▁is ▁produced ▁by ▁end ogen ous ▁or ▁ex ogen ous ▁dam aging ▁factors . ▁However , ▁m t D NA ▁is ▁not ▁inserted ▁at ▁any ▁location ▁within ▁the ▁gen ome . ▁Moreover , ▁there ▁is ▁no ▁correlation ▁between ▁the ▁fraction ▁of ▁non c oding ▁DNA ▁and ▁NUM T ▁abund ance ; ▁In ▁addition , ▁Ant unes ▁and ▁Ram os ▁found ▁that ▁old ▁NUM T s ▁are ▁inserted ▁prefer entially ▁into ▁the ▁known ▁and ▁predicted ▁lo ci , ▁as ▁infer red ▁for ▁recent ▁NUM T s ▁in ▁the ▁human ▁gen ome , ▁during ▁their ▁vig orous ▁work ▁on ▁NUM T ▁sequence ▁in ▁fish es ▁using ▁B LA ST N ▁analysis ▁method . ▁Therefore , ▁based ▁on ▁these ▁studies , ▁the ▁insert ion ▁of ▁NUM T ▁in ▁nuclear ▁gen ome ▁is ▁found ▁to ▁be ▁non - random . ▁One ▁of ▁the ▁best ▁studies ▁prov ing ▁the ▁non - random ▁distribution ▁and ▁insert ion ▁of ▁NUM T s ▁in ▁the ▁nuclear ▁gen ome ▁is ▁done ▁by ▁T su ji ▁and ▁his ▁team m ates . ▁Using ▁the ▁LA ST ▁method ▁instead ▁of ▁B LA ST , ▁which ▁makes ▁computing ▁E - value ▁with ▁higher ▁accuracy ▁possible ▁and ▁does ▁not ▁under - re present ▁the ▁repet itive ▁elements ▁in ▁NUM T ▁fl anks , ▁T su ji ▁and ▁his ▁team mate