S . ▁Route ▁ 6 0 , ▁U . S . ▁Route ▁ 6 1 , ▁U . S . ▁Route ▁ 6 2 , ▁and ▁Route ▁ 1 1 4 . ▁S ik eston ' s ▁location ▁at ▁the ▁intersection ▁of ▁U . S . ▁Rout es ▁ 6 0 , ▁ 6 1 , ▁and ▁ 6 2 ▁makes ▁the ▁city ▁one ▁of ▁the ▁few ▁towns ▁located ▁at ▁the ▁intersection ▁of ▁three ▁consec ut ively ▁number ed ▁high ways . ▁ ▁Econom y ▁As ▁measured ▁in ▁ 2 0 0 8 , ▁the ▁cost ▁of ▁living ▁index ▁in ▁S ik eston ▁is ▁low ▁( 8 0 . 4 ) ▁compared ▁to ▁the ▁U . S . ▁average ▁of ▁ 1 0 0 . ▁The ▁un emp loyment ▁rate ▁was ▁ 7 . 6 ▁percent ▁in ▁S ik eston . ▁▁ ▁The ▁major ▁city ▁employ ers ▁include ▁Un ile ver , ▁Missouri ▁D elta ▁Medical ▁Center , ▁the ▁S ik eston ▁Public ▁School s ▁system , ▁and ▁Wal - Mart . ▁ ▁In ▁ 1 9 0 4 , ▁the ▁Little ▁River ▁D rain age ▁District ▁was ▁formed . ▁Agricult ure ▁products ▁of ▁the ▁area ▁include ▁cot ton , ▁so y beans , ▁corn , ▁rice , ▁wat erm el ons , ▁whe at , ▁mil o , ▁pot atoes , ▁and ▁p oul try ▁with ▁native ▁trees ▁that ▁include ▁o ak ▁and ▁cy press . ▁Histor ically , ▁the ▁city ▁was ▁known ▁for ▁its ▁two ▁large ▁fl our ▁mill s .