ok I ▁nuc lease ▁analog ous ▁to ▁T A LE N . ▁Adv antages ▁include ▁a ▁shorter ▁repeat ▁size , ▁more ▁compact ▁domain ▁structure ▁( no ▁large ▁non - repeat ▁domains ), ▁greater ▁repeat ▁sequence ▁divers ity ▁en abling ▁the ▁use ▁of ▁PC R ▁on ▁the ▁gen es ▁encoding ▁them ▁and ▁making ▁them ▁less ▁vulner able ▁to ▁recom bin atorial ▁repeat ▁loss . ▁In ▁addition , ▁Bur k holder ia ▁T A LE - lik es ▁have ▁no ▁T - zero ▁requirement ▁relax ing ▁the ▁constraints ▁on ▁DNA ▁target ▁selection . ▁However , ▁few ▁uses ▁of ▁Bur k holder ia ▁T A LE - lik es ▁as ▁program m able ▁DNA ▁binding ▁prote ins ▁have ▁been ▁published , ▁outside ▁of ▁the ▁original ▁character ization ▁publications . ▁ ▁M Or TL s ▁ ▁Disc overy ▁ ▁In ▁ 2 0 0 7 ▁the ▁results ▁of ▁a ▁met agen omic ▁swe ep ▁of ▁the ▁world ' s ▁o ce ans ▁by ▁the ▁J . ▁Craig ▁V enter ▁Institute ▁were ▁made ▁public ly ▁available . ▁The ▁paper ▁in ▁ 2 0 1 4 ▁on ▁Bur k holder ia ▁T A LE - lik es ▁ ▁was ▁also ▁the ▁first ▁to ▁report ▁that ▁two ▁entries ▁from ▁that ▁database ▁res emble d ▁T A LE - lik es , ▁based ▁on ▁sequence ▁similarity . ▁These ▁were ▁further ▁character ized ▁and ▁ass essed ▁for ▁their ▁DNA - binding ▁potential ▁in ▁ 2 0 1 5 . ▁The ▁repeat ▁units ▁encoded ▁by ▁these ▁sequences ▁were ▁found ▁to ▁medi ate ▁DNA