. ▁ ▁Natural ▁habitat ▁▁ ▁Kar un ar ath na e ▁also ▁proposed ▁that ▁Rh inos por id ium ▁existed ▁in ▁a ▁dim orph ic ▁state — a ▁sap rot roph ▁in ▁soil ▁and ▁water ▁and ▁a ▁ye ast ▁form ▁inside ▁living ▁t issues . ▁Rec ent ▁studies ▁done ▁using ▁flu ores cent ▁in ▁situ ▁hy brid ization ▁techniques ▁provide ▁evidence ▁that ▁its ▁natural ▁habitat ▁is ▁res er voir ▁water , ▁and ▁perhaps , ▁soil ▁cont amin ated ▁with ▁this ▁water . ▁ ▁Path ology ▁▁ ▁One ▁report ▁indicates ▁that ▁patients ▁with ▁rh inos por id ios is ▁possess ▁anti - R . ▁see ber i ▁Ig G ▁to ▁an ▁inner ▁wall ▁ant igen ▁expressed ▁only ▁during ▁the ▁m ature ▁sp or ang ial ▁stage . ▁This ▁finding ▁suggests ▁that ▁the ▁mapping ▁of ▁ant igen ic ▁prote ins ▁may ▁lead ▁to ▁important ▁ant ig ens ▁with ▁the ▁potential ▁as ▁v acc ine ▁candidates . ▁ ▁Hum oral ▁and ▁cell - medi ated ▁imm une ▁responses ▁in ▁human ▁patients ▁and ▁in ▁experimental ▁m ice ▁have ▁been ▁defined ; ▁several ▁mechan isms ▁of ▁imm une ▁ev asion ▁by ▁R . ▁see ber i ▁have ▁been ▁identified . ▁ ▁A ▁novel ▁method ▁for ▁the ▁determ ination ▁of ▁the ▁vi ability ▁of ▁rh inos por id ial ▁end os por es ▁by ▁M TT - redu ction ▁led ▁to ▁the ▁study ▁of ▁the ▁sens itivity ▁of ▁end os por es ▁to ▁bi oc ides ▁and ▁ant im icro b ial ▁dru gs ▁( paper ▁in ▁prepar ation