▁which ▁are ▁now ▁commonly ▁used ▁to ▁treat ▁high ▁ch ol ester ol . ▁ ▁Wilson ' s ▁disease ▁Pen ic ill am ine ▁was ▁developed ▁to ▁treat ▁Wilson ' s ▁disease , ▁a ▁rare ▁her edit ary ▁disease ▁that ▁can ▁lead ▁to ▁a ▁fatal ▁accum ulation ▁of ▁co pper ▁in ▁the ▁body . ▁This ▁drug ▁was ▁later ▁found ▁to ▁be ▁effective ▁in ▁tre ating ▁ar th rit is . ▁Bis - ch oline ▁t etr ath iom oly b date ▁is ▁currently ▁under ▁investigation ▁as ▁a ▁ther apy ▁against ▁Wilson ' s ▁disease . ▁ ▁Ph osph ol ip ase ▁ 2 G 6 - associ ated ▁ne uro de gener ation ▁ ▁In ▁ 2 0 1 7 , ▁F DA ▁granted ▁R T 0 0 1 ▁or phan ▁drug ▁design ation ▁in ▁the ▁treatment ▁of ▁ph osph ol ip ase ▁ 2 G 6 - associ ated ▁ne uro de gener ation ▁( PL AN ). ▁ ▁Activ ism , ▁research ▁cent ers ▁The ▁Center ▁for ▁Or phan ▁D rug ▁Research ▁at ▁the ▁University ▁of ▁Minnesota ▁College ▁of ▁Ph arm acy ▁helps ▁small ▁companies ▁with ▁ins u fficient ▁in - house ▁expert ise ▁and ▁resources ▁in ▁drug ▁synth esis , ▁form ulation , ▁ph arma com et rics , ▁and ▁bio - analysis . ▁The ▁Ke ck ▁Gr adu ate ▁Institute ▁Center ▁for ▁R are ▁D ise ase ▁Ther ap ies ▁( CR DT ) ▁in ▁Cla rem ont , ▁California , ▁supports ▁projects ▁to ▁rev ive ▁potential ▁or phan ▁dru