se al ▁d ys pl asia ▁and ▁an emia ▁that ▁was ▁not ▁respons ive ▁to ▁h emat in ics . ▁Bro aden ing ▁of ▁the ▁long ▁b ones , ▁specifically ▁in ▁the ▁dia phys es , ▁is ▁usually ▁thought ▁of ▁as ▁Eng lem ann ▁disease , ▁but ▁patients ▁showed ▁both ▁dia phys es ▁and ▁the ▁met aph ys es ▁to ▁be ▁affected . ▁This ▁minor ▁detail ▁when ▁it ▁comes ▁to ▁Eng lem ann ▁disease ▁is ▁essential ▁because ▁there ▁is ▁a ▁consistent ▁mention ▁of ▁the ▁met aph ys es ▁of ▁the ▁long ▁b ones ▁to ▁have ▁been ▁una ffect ed . ▁Even ▁though ▁some ▁patients ▁suffering ▁from ▁Gh os al ▁h emat odia phy se al ▁d ys pl asia ▁had ▁difficulty ▁walking , ▁this ▁is ▁not ▁a ▁consistent ▁sympt om ▁found ▁with ▁people ▁affected ▁by ▁the ▁disease , ▁even ▁though ▁it ▁is ▁a ▁cru cial ▁characteristic ▁of ▁Eng lem ann ▁disease . ▁ ▁Some ▁patients ▁had ▁low ▁hem og lo bin ▁values ▁suffering ▁from ▁Eng lem ann ▁disease . ▁Unfortunately , ▁an emia ▁is ▁a ▁consistent ▁feature ▁of ▁Gh os al ▁h emat odia phy se al ▁d ys pl asia ▁with ▁the ▁sever ity ▁of ▁said ▁an emia ▁to ▁include ▁multiple ▁blood ▁trans f us ions . ▁ ▁The ▁gene ▁responsible ▁for ▁Gh os al ▁h emat odia phy se al ▁d ys pl asia ▁is ▁likely ▁T B X AS 1 . ▁A ▁gen ome - wide ▁study ▁was ▁done ▁on ▁two ▁families ▁with ▁the ▁disease ▁found ▁that ▁the ▁likely ▁cul