▁a ▁characteristic ▁feature ▁of ▁natural ▁lig ands . ▁The ▁following ▁list ▁includes ▁the ▁most ▁prominent ▁examples : ▁▁ ▁k yn uren ic ▁acid ▁ ▁L PA ▁species ▁▁ ▁cy clic ▁gu anos ine ▁mon oph osph ate ▁▁ ▁D H IC A ▁▁ ▁T 3 ▁▁ ▁reverse ▁T 3 ▁ ▁Syn th etic ▁ag on ists ▁▁ ▁Other ▁synth etic ▁ag on ists ▁of ▁G PR 3 5 ▁include : ▁ ▁c rom og lic ic ▁acid ▁▁ ▁ned oc rom il ▁▁ ▁p amo ic ▁acid ▁ ▁zap rin ast ▁▁ ▁l odox am ide ▁ ▁buf rol in ▁ ▁Z ap rin ast ▁is ▁currently ▁the ▁gold ▁standard ▁in ▁the ▁bio chem ical ▁evaluation ▁of ▁novel ▁synth etic ▁G PR 3 5 ▁ag on ists , ▁because ▁it ▁remains ▁pot ent ▁in ▁an ▁animal ▁model . ▁Most ▁other ▁known ▁ag on ists ▁display ▁high ▁select ivity ▁towards ▁the ▁human ▁G PR 3 5 ▁orth olog ue . ▁This ▁phenomen on ▁is ▁well ▁established ▁for ▁other ▁G PC R s ▁and ▁comp licates ▁the ▁development ▁of ▁ph arma ce ut ical ▁dru gs . ▁ ▁An tagon ists ▁▁ ▁An tagon ists ▁of ▁G PR 3 5 ▁include : ▁ ▁ML 1 4 5 ▁( C ID - 2 2 8 6 8 1 2 ) ▁ ▁ML 1 4 4 ▁( C ID - 1 5 4 2 1 0 3 ) ▁ ▁Both ▁ML 1 4 5 ▁and ▁ML 1 4 4 ▁unf url ▁their ▁ant agon istic ▁activity ▁through