▁cancer ▁diagn osed ▁before ▁age ▁ 5 0 ▁▁ 2 . ▁Pres ence ▁of ▁synchron ous ▁or ▁met ach ron ous ▁col ore ct al ▁or ▁other ▁Lyn ch ▁synd rome ▁associated ▁can cers ▁( e . g . ▁can cers ▁of ▁end omet rium , ▁ov ary , ▁st om ach , ▁small ▁bow el , ▁pan cre as , ▁b ili ary ▁tract , ▁u re ter , ▁ren al ▁pel vis , ▁brain , ▁se b ace ous ▁g lands , ▁ker ato ac anth omas ) ▁▁ 3 . ▁Col ore ct al ▁cancer ▁with ▁M SI - high ▁path ology ▁in ▁a ▁person ▁who ▁is ▁younger ▁than ▁ 6 0 ▁years ▁of ▁age ▁▁ 4 . ▁Col ore ct al ▁cancer ▁diagn osed ▁in ▁a ▁person ▁with ▁one ▁or ▁more ▁first - deg ree ▁relative ▁with ▁col ore ct al ▁cancer ▁or ▁Lyn ch ▁synd rome ▁associated ▁tum our ▁diagn osed ▁under ▁age ▁ 5 0 ▁▁ 5 . ▁Person ▁with ▁col ore ct al ▁cancer ▁and ▁two ▁or ▁more ▁first - ▁or ▁second - deg ree ▁relatives ▁with ▁col ore ct al ▁cancer ▁or ▁Lyn ch ▁synd rome ▁associated ▁cancer ▁diagn osed ▁at ▁any ▁age ▁ ▁It ▁is ▁important ▁to ▁note ▁that ▁these ▁clin ical ▁criteria ▁can ▁be ▁difficult ▁to ▁use ▁in ▁practice ▁and ▁clin ical ▁criteria ▁used ▁alone ▁miss es ▁between ▁ 1 2 ▁and ▁ 6 8 ▁percent ▁of ▁Lyn ch ▁Sy nd rome ▁cases . ▁ ▁S urg ery ▁ ▁Pro phy la ctic