0 7 ▁is ▁expressed ▁highest ▁in ▁the ▁p ine al ▁g land , ▁pre front al ▁cor tex , ▁c ing ulate ▁cor tex , ▁and ▁sub th al am ic ▁nucle us . ▁ ▁D ise ase ▁Association ▁ ▁K I AA 1 1 0 7 ▁was ▁found ▁to ▁be ▁over ▁expressed ▁in ▁brain ▁white ▁matter ▁with ▁Multiple ▁S cl eros is ▁brain ▁les ions ▁when ▁compared ▁to ▁control ▁white ▁matter . ▁The ▁average ▁non - d ise ased ▁sample ▁had ▁neg lig ible ▁expression ▁of ▁K I AA 1 1 0 7 , ▁while ▁in ▁the ▁dise ased ▁sample ▁it ▁was ▁expressed ▁higher ▁than ▁almost ▁any ▁other ▁gene ▁( 9 5 th - 9 8 th ▁percent ile ▁of ▁expression ). ▁ ▁Hom ology ▁ ▁Orth olog s ▁ ▁Orth olog s ▁of ▁K I AA 1 1 0 7 ▁exist ▁in ▁most ▁verte br ates . ▁The ▁most ▁distant ▁hom olog ▁of ▁K I AA 1 1 0 7 ▁was ▁found ▁in , ▁a ▁fish , ▁the ▁Amazon ▁Mol ly . ▁There ▁were ▁no ▁hom olog s ▁found ▁for ▁sh arks ▁and ▁ray s , ▁which ▁would ▁suggest ▁that ▁K I AA 1 1 0 7 ▁origin ated ▁in ▁fish . ▁ ▁There ▁are ▁no ▁human ▁par al ogs ▁for ▁K I AA 1 1 0 7 . ▁ ▁References ▁ ▁Further ▁reading <0x0A> </s> ▁David ▁Š k och ▁and ▁Tom áš ▁Z í b ▁were ▁the ▁def ending ▁champions , ▁but ▁did ▁not ▁particip ate ▁together ▁this ▁year .