. org ▁ ▁Paul ▁E . ▁Hoff man , ▁American ▁historian , ▁winner ▁of ▁the ▁Francis ▁Park man ▁Prize ▁ ▁See ▁also ▁Paul ▁Hoff mann ▁( disambiguation ) <0x0A> </s> ▁T ios p ir one ▁( B MY - 1 3 , 8 5 9 ), ▁also ▁sometimes ▁called ▁t ias p ir one ▁or ▁t ios per one , ▁is ▁an ▁at yp ical ▁anti ps ych otic ▁of ▁the ▁az ap ir one ▁class . ▁It ▁was ▁investig ated ▁as ▁a ▁treatment ▁for ▁sch iz op hren ia ▁in ▁the ▁late ▁ 1 9 8 0 s ▁and ▁was ▁found ▁to ▁have ▁an ▁effect iveness ▁equivalent ▁to ▁those ▁of ▁typical ▁anti ps ych ot ics ▁in ▁clin ical ▁tri als ▁but ▁without ▁causing ▁extra py ram idal ▁side ▁effects . ▁However , ▁development ▁was ▁halt ed ▁and ▁it ▁was ▁not ▁market ed . ▁Per osp ir one , ▁another ▁az ap ir one ▁derivative ▁with ▁anti ps ych otic ▁properties , ▁was ▁synth es ized ▁and ▁ass ay ed ▁several ▁years ▁after ▁t ios p ir one . ▁It ▁was ▁found ▁to ▁be ▁both ▁more ▁pot ent ▁and ▁more ▁select ive ▁in ▁comparison ▁and ▁was ▁commercial ized ▁instead . ▁ ▁Ph arm ac ology ▁ ▁Ph arm ac od ynam ics ▁T ios p ir one ▁acts ▁as ▁a ▁ 5 - HT 1 A ▁re ceptor ▁partial ▁ag on ist , ▁ 5 - HT 2 A , ▁ 5 - HT 2 C , ▁and ▁ 5 - HT