▁with ▁a ▁T CF 4 ▁delet ion ▁can ▁lack ▁the ▁synd rome ' s ▁characteristic ▁fa cial ▁features . ▁ ▁Di agn osis ▁There ▁is ▁not ▁a ▁certain ▁di agnostic ▁criteria , ▁but ▁there ▁are ▁a ▁few ▁sympt oms ▁that ▁support ▁a ▁diagn osis ▁of ▁P TH S . ▁Some ▁examples ▁are : ▁fa cial ▁d ys m oph ism , ▁early ▁on set ▁global ▁development al ▁delay , ▁moder ate ▁to ▁severe ▁intellectual ▁dis ability , bre ath ing ▁ab normal ities , ▁and ▁a ▁lack ▁of ▁other ▁major ▁con gen ital ▁ab normal ities . ▁ ▁Half ▁of ▁the ▁individuals ▁with ▁P TH S ▁are ▁reported ▁to ▁have ▁se iz ures , ▁starting ▁from ▁child hood ▁to ▁the ▁late ▁te ens . ▁▁▁ ▁Ar ound ▁ 5 0 % ▁of ▁those ▁affected ▁show ▁ab normal ities ▁on ▁brain ▁imag ing . ▁These ▁include ▁a ▁hyp op last ic ▁cor pus ▁call os um ▁with ▁a ▁missing ▁ro str um ▁and ▁posterior ▁part ▁of ▁the ▁spl enium , ▁with ▁bul b ous ▁ca ud ate ▁nuc lei ▁bul ging ▁towards ▁the ▁front al ▁horn s . ▁ ▁Elect ro ence phal og rams ▁show ▁an ▁excess ▁of ▁slow ▁components . ▁ ▁According ▁to ▁the ▁clin ical ▁diagn osis . ▁P TH S ▁is ▁in ▁the ▁same ▁group ▁as ▁Per vas ive ▁Development al ▁Dis orders . ▁ ▁E valu ations ▁▁ ▁Development al ▁assess ment ▁ ▁Ass ess ment ▁for ▁communication ▁devices ▁ ▁Child ▁behavior ▁special ist ▁ ▁Pul mon ary ▁consult