▁an ▁experimental ▁drug ▁candidate ▁in ▁the ▁family ▁of ▁ph arm ac ological ▁cycl in - dependent ▁kin ase ▁( CD K ) ▁in hib itors ▁that ▁prefer entially ▁in hib it ▁multiple ▁en zym e ▁targets ▁including ▁CD K 2 , ▁CD K 7 ▁and ▁CD K 9 , ▁which ▁alter ▁the ▁growth ▁phase ▁or ▁state ▁within ▁the ▁cell ▁cycle ▁of ▁treated ▁cells . ▁ ▁Sel ic ic lib ▁is ▁being ▁developed ▁by ▁Cy cla cel . This ▁is ▁a ▁phase ▁II , ▁do se ▁r anging , ▁mult ic enter , ▁random ized , ▁double - bl ind , ▁place bo - control led ▁study . ▁ ▁The ▁aim ▁of ▁this ▁study ▁is ▁to ▁assess ▁the ▁safety ▁of ▁increasing ▁dos es ▁of ▁ro sc ov it ine ▁admin ister ed ▁or ally ▁for ▁ 4 ▁cycles ▁of ▁ 4 ▁consecutive ▁days ▁( tre at ment ▁" on ") ▁separated ▁by ▁a ▁ 3 ▁days ▁treatment ▁free ▁period ▁( tre at ment ▁" off ") ▁in ▁adult ▁CF ▁subjects ▁with ▁C yst ic ▁F ib ros is ▁carrying ▁ 2 ▁C yst ic ▁F ib ros is ▁causing ▁mut ations ▁with ▁at ▁least ▁one ▁F 5 0 8 del - CF TR ▁mut ation ▁and ▁chron ically ▁inf ected ▁with ▁Pseud omon as ▁aer ugin osa . ▁ ▁This ▁study ▁involved ▁ 3 6 ▁C yst ic ▁F ib ros is ▁patients : ▁ 2 4 ▁treated ▁and ▁ 1 2 ▁controls . ▁ ▁Sel ic ic lib ▁is ▁being ▁research ed ▁for