▁order ▁to ▁reach ▁his ▁conclus ions , ▁T ort i ▁carried ▁out ▁a ▁series ▁of ▁tri als , ▁experiment ing ▁with ▁different ▁dos ages ▁and ▁methods ▁of ▁administration . ▁T ort i ▁concluded ▁that ▁while ▁the ▁procedure ▁described ▁in ▁the ▁Sch ed ula ▁Rom ana ▁was ▁appropriate ▁for ▁simple ▁cases ▁such ▁as ▁t ert ian ▁fe ver , ▁the ▁dos age ▁should ▁be ▁increased ▁in ▁the ▁case ▁of ▁more ▁complicated ▁t ert ian ▁and ▁per n icious ▁fe vers . ▁ ▁Re ception ▁and ▁legacy ▁ ▁The ▁Th era pe ut ice ▁Special is ▁helped ▁establish ▁the ▁use ▁of ▁cin ch ona ▁b ark , ▁particularly ▁dealing ▁with ▁the ▁question ▁of ▁which ▁type ▁of ▁fe ver ▁would ▁respond . ▁The ▁book ▁classification ▁and ▁different iation ▁of ▁fe vers ▁and ▁the ▁recognition ▁that ▁only ▁certain ▁fe vers ▁could ▁be ▁treated ▁by ▁cin ch ona ▁was ▁of ▁major ▁importance . ▁By ▁the ▁end ▁of ▁the ▁ 1 8 th ▁century , ▁form ulations ▁were ▁more ▁standard ized ▁and ▁cin ch ona ▁was ▁established ▁as ▁legit imate ▁drug ▁for ▁general ▁use ▁against ▁specific ▁inter mitt ent ▁fe vers . ▁ ▁See ▁also ▁▁ ▁Qu in ine ▁Sch ed ula ▁Rom ana ▁History ▁of ▁mal aria ▁ ▁References ▁ ▁External ▁links ▁▁ ▁Complete ▁digital ▁fac sim ile ▁of ▁Th era pe ut ice ▁Special is ▁ad ▁Feb res ▁Period icas ▁P ern icios as ▁( 1 7 5 6 ) ▁from ▁the ▁John ▁Carter ▁Brown ▁Library ▁ ▁Category : Ital ian ▁medical ▁research ▁Category : Book s