▁polynomials ▁with ▁coefficients ▁in ▁finite ▁fields . ▁ ▁Ad rien - Marie ▁Leg endre ▁conject ures ▁the ▁prime ▁number ▁theorem . ▁ ▁Medicine ▁ ▁May ▁ 1 4 ▁– ▁Edward ▁Jen ner ▁admin ister s ▁the ▁first ▁small po x ▁v acc ination . ▁ ▁Franz ▁Joseph ▁Gall ▁develop s ▁his ▁theory ▁of ▁' c ran ios copy ', ▁a ▁for er un ner ▁of ▁phr en ology . ▁ ▁The ▁Ret re at ▁established ▁in ▁York , ▁England ; ▁it ▁pione ers ▁the ▁hum ane ▁treatment ▁of ▁people ▁with ▁mental ▁dis orders . ▁ ▁Pale ont ology ▁ ▁April ▁ 4 ▁– ▁Georges ▁C uv ier ▁reads ▁his ▁paper ▁M ém oires ▁sur ▁les ▁esp èces ▁d ' élé ph ants ▁viv ants ▁et ▁foss iles ▁at ▁the ▁opening ▁of ▁the ▁Institut ▁National ▁in ▁Paris , ▁demonstr ating ▁that ▁species ▁had ▁become ▁ext inct . ▁ ▁Technology ▁ ▁Comple tion ▁of ▁the ▁first ▁cast ▁iron ▁aqu ed uct s , ▁on ▁the ▁English ▁can als ▁ ▁February ▁– ▁Hol mes ▁Aqu ed uct ▁on ▁the ▁Derby ▁Canal , ▁designed ▁by ▁Benjamin ▁Out ram ▁( dem ol ished ▁ 1 9 7 1 ). ▁ ▁March ▁– ▁Long don - on - T ern ▁Aqu ed uct ▁on ▁the ▁Sh rew s bury ▁Canal , ▁designed ▁by ▁Thomas ▁T elf ord ▁( ext ant ). ▁ ▁August ▁ 9 ▁– ▁Open ing ▁to ▁traffic ▁of ▁the ▁W ear mouth ▁Bridge ▁in ▁England , ▁designed ▁by ▁Thomas ▁Pa ine ▁in ▁cast ▁iron . ▁The