▁reasons ▁for ▁the ▁delay ▁at ▁in ▁vit ro ▁culture , ▁and ▁establishment ▁of ▁disease ▁in ▁experimental ▁animals , ▁hence ▁pau city ▁of ▁information ▁on ▁its ▁sens itivity ▁to ▁dru gs , ▁and ▁the ▁imm un ology ▁of ▁the ▁path ogen . ▁Thank am ani ▁isolated ▁an ▁organ ism ▁believed ▁to ▁be ▁R . ▁see ber i ▁and ▁gave ▁the ▁name ▁" UM H . 4 8 ." ▁It ▁was ▁originally ▁isolated ▁from ▁the ▁bi ops ies ▁and ▁nas al ▁sw abs ▁of ▁rh inos por id ios is ▁patients . ▁ ▁The ▁various ▁development al ▁stages ▁of ▁U M H . 4 8 ▁showed ▁a ▁strong ▁res embl ance ▁with ▁the ▁structures ▁seen ▁in ▁his op ath ological ▁sections ▁of ▁rh inos por id ios is ▁in ▁t issue ▁samples . ▁The ▁sp ores ▁of ▁U M H . 4 8 ▁were ▁found ▁to ▁be ▁vi able ▁even ▁after ▁a ▁de cade ▁of ▁pres ervation ▁in ▁the ▁re fr iger ator ▁without ▁any ▁sub c ulture , ▁res emb ling ▁the ▁features ▁of ▁Syn chy tri um ▁end obi otic um , ▁a ▁lower ▁aqu atic ▁fung us ▁that ▁causes ▁black ▁w art ▁disease ▁in ▁pot atoes . ▁However , ▁carefully ▁performed ▁mole cular ▁studies ▁showed ▁the ▁definit ive ▁identity ▁of ▁the ▁organ ism . ▁▁ ▁discuss es ▁recent ▁research ▁develop ments ▁and ▁clin ical ▁associations ▁of ▁this ▁en ig m atic ▁disease . ▁ ▁Ph y log eny ▁▁ ▁For ▁most ▁of ▁the ▁ 2 0 th ▁century , ▁the ▁classification ▁of