▁been ▁conducted ▁on ▁the ▁labor atory ▁mouse , ▁Mus ▁mus cul us , ▁as ▁it ▁is ▁used ▁as ▁a ▁model ▁of ▁human ▁hel min th ▁in fection ▁to ▁which ▁a ▁spectrum ▁of ▁natural ▁resistance ▁to ▁par as ite ▁in fection ▁exists . ▁ ▁Path ogen icity ▁ ▁Upon ▁in fection ▁with ▁H . ▁poly gy rus , ▁inn ate ▁and ▁adapt ive ▁host ▁imm une ▁responses ▁are ▁generated ▁to ▁prevent ▁the ▁establishment ▁of ▁the ▁par as ite ▁in ▁the ▁gut . ▁A ▁strong ▁w ound - he aling ▁imm une ▁response ▁( Th 2 - type ) ▁associated ▁with ▁int est inal ▁path ology ▁is ▁mounted . ▁Similar ▁to ▁other ▁round w orm ▁in fe ctions , ▁Th 2 ▁imm unity ▁focus es ▁on ▁elimin ating ▁the ▁par as ite ▁or ▁conf ining ▁it ▁to ▁minim ize ▁host ▁damage . ▁ ▁M uc us ▁secret ed ▁by ▁go ble t ▁cells ▁of ▁the ▁int est ine ▁acts ▁as ▁the ▁first ▁line ▁of ▁defense , ▁hence ▁increases ▁in ▁go ble t ▁cell ▁number ▁are ▁a ▁major ▁observable ▁change ▁during ▁H . ▁poly gy rus ▁in fection . ▁Mac roph ages ▁are ▁activ ated ▁through ▁Th 2 ▁cy tok ines ▁and ▁they ▁are ▁important ▁in ▁par as ite ▁clear ance ▁by ▁increase ▁int est inal ▁mot ility ▁and ▁to ▁indu ce ▁fib ros is ▁and ▁he aling . ▁These ▁imm une ▁cells ▁are ▁also ▁important ▁in ▁gran ul oma ▁formation . ▁This ▁is ▁a ▁def ensive ▁response ▁by ▁the ▁host ▁to ▁trap ▁the ▁par as