intendo ▁released ▁several ▁follow - up ▁titles ▁in ▁the ▁Dr . ▁Mario ▁series . ▁Dr . ▁Mario ▁ 6 4 , ▁released ▁in ▁ 2 0 0 1 ▁for ▁the ▁N intendo ▁ 6 4 , ▁features ▁W ario ▁and ▁several ▁W ario ▁Land ▁ 3 ▁characters , ▁and ▁offers ▁numerous ▁game ▁modes , ▁including ▁a ▁story - f oc used ▁single - player ▁mode . ▁The ▁game ▁also ▁supports ▁simultane ous ▁multi player ▁for ▁up ▁to ▁four ▁players ▁at ▁once . ▁Dr . ▁Mario ▁ 6 4 ▁was ▁subsequently ▁released ▁in ▁Japan ▁in ▁the ▁compilation ▁game ▁N intendo ▁P uzz le ▁Collection ▁on ▁the ▁Game C ube . ▁Dr . ▁Mario ▁Online ▁R x , ▁released ▁in ▁ 2 0 0 8 ▁on ▁W ii W are , ▁offers ▁online ▁multi player ▁via ▁N intendo ▁Wi - Fi ▁Connection . ▁Dr . ▁Mario ▁Express , ▁released ▁in ▁ 2 0 0 9 ▁for ▁the ▁N intendo ▁D Si , ▁does ▁not ▁support ▁multi player ▁game play . ▁Dr . ▁Luigi , ▁released ▁in ▁ 2 0 1 3 , ▁features ▁Luigi ▁as ▁a ▁play able ▁character ▁and ▁has ▁all ▁the ▁modes ▁in ▁Dr . ▁Mario ▁Online ▁R x , ▁as ▁well ▁as ▁a ▁new ▁mode ▁with ▁L - sh aped ▁caps ules . ▁The ▁latest ▁install ment , ▁Dr . ▁Mario : ▁Mi racle ▁C ure , ▁was ▁released ▁in ▁ 2 0 1 5 ▁and ▁introduced ▁power - ups ▁to ▁the ▁series . ▁There ▁is ▁also ▁a ▁mobile ▁game ▁called ▁Dr