▁levels ▁fl uct uate ▁during ▁the ▁men stru al ▁cycle ▁but ▁reach ▁a ▁steady ▁decl ine ▁and ▁then ▁remain ▁at ▁low ▁levels ▁post men op ause . ▁ ▁Be havior al ▁studies ▁suggest ▁that ▁est rad i ol ▁aug ments ▁cogn ition ▁that ▁occurs ▁within ▁the ▁pre front al ▁cor tex ▁and ▁hi pp oc amp us . ▁ ▁It ▁can ▁also ▁enh ance ▁long ▁term ▁pot enti ation ▁( L TP ) ▁which ▁is ▁key ▁at ▁the ▁ne uro cell ular ▁level ▁for ▁memory ▁and ▁learning ▁and ▁is ▁mostly ▁affected ▁at ▁the ▁ne uro an atom ical ▁level ▁of ▁CA 1 ▁py ram idal ▁cells , ▁N MD Ar ▁re cept ors , ▁and ▁A MP Ar ▁re cept ors . ▁ ▁Micro gl ia ▁are ▁gli al ▁cells ▁in ▁the ▁brain ▁that ▁make ▁est ro gen ▁and ▁produce ▁cy tok ines ▁and ▁imm une ▁prote ins ▁in ▁response ▁to ▁est ro gen . ▁ ▁These ▁cells ▁play ▁a ▁large ▁role ▁in ▁ne uro infl amm ation ▁which ▁can ▁in ▁turn ▁lead ▁to ▁dis orders ▁such ▁as ▁Multiple ▁S cl eros is , ▁Al z heimer ' s ▁disease , ▁and ▁Park inson ' s ▁disease . ▁ ▁Est ro gen ▁can ▁play ▁an ▁anti - infl am mat ory ▁role ▁with ▁micro gl ia , ▁which ▁can ▁protect ▁the ▁C NS ▁against ▁the ▁stim uli ▁that ▁promote ▁such ▁dise ases . ▁ ▁End orph ins ▁modify ▁core ▁body ▁temperature ▁and ▁trigger ▁mechan isms ▁which ▁allow ▁the ▁body ▁to ▁reduce ▁heat ▁such