▁ ▁Ne vi rap ine ▁may ▁cause ▁severe ▁or ▁life - th re aten ing ▁li ver ▁to x icity , ▁usually ▁emer ging ▁in ▁the ▁first ▁six ▁weeks ▁of ▁treatment . D H HS ▁panel . ▁Gu idel ines ▁for ▁the ▁use ▁of ▁ant ire t ro vir al ▁agents ▁in ▁H IV - 1 - in fect ed ▁adult s ▁and ▁ad oles c ents ▁( May ▁ 4 , ▁ 2 0 0 6 ). ▁( Available ▁for ▁download ▁from ▁A ID S Info ▁) ▁In ▁ 2 0 0 0 , ▁the ▁U . S . ▁Food ▁and ▁D rug ▁Administration ▁issued ▁a ▁black ▁box ▁warning ▁on ▁ne vi rap ine , ▁warning ▁that ▁it ▁could ▁cause ▁life - th re aten ing ▁li ver ▁to x icity ▁and ▁skin ▁re actions . ▁Un accept ably ▁high ▁risk ▁of ▁serious ▁li ver ▁sympt oms ▁in ▁certain ▁patient ▁groups ▁( w omen ▁with ▁CD 4 ▁count ▁> 2 5 0 ▁and ▁men ▁> 4 0 0 ) ▁has ▁led ▁the ▁U . S . ▁D H HS ▁to ▁recommend ▁the ▁restriction ▁of ▁ne vi rap ine ▁use ▁to ▁those ▁at ▁lower ▁risk , ▁unless ▁the ▁benefit ▁to ▁the ▁patient ▁clearly ▁out we igh s ▁the ▁risk ; ▁although ▁in ▁the ▁ 2 NN ▁study ▁which ▁found ▁these ▁CD 4 ▁limits , ▁the ▁effect ▁was ▁seen ▁only ▁in ▁patients ▁rec ru ited ▁from ▁Th ailand . ▁More ▁recent ▁studies ▁on ▁the ▁use ▁of ▁Ne vi rap ine ▁in ▁people ▁with ▁higher