▁when ▁the ▁cell ▁detect s ▁cell ▁damage ▁or ▁defect s ) ▁in ▁P LA G 1 ▁ ▁( ple omorphic ▁ad en oma ▁gene - like ▁ 1 ). ▁P LA G 1 ▁ ▁is ▁a ▁trans cription ▁reg ulator ▁of ▁the ▁type ▁ 1 ▁re ceptor ▁for ▁p itu it ary ▁ad en yl ated ▁cycl ase - activ ating ▁pol ype pt ide ▁( is ▁a ▁pol ype pt ide ▁that ▁activ ates ▁ad en yl ate ▁cycl ase ▁and ▁increases ▁the ▁cy clic ▁ad en os ine ▁mon oph osph ate ▁or ▁c AMP . ▁c AMP ▁is ▁a ▁second ▁mess enger ▁that ▁is ▁used ▁for ▁neighbor ing ▁cells ▁to ▁perform ▁ ▁signal ▁trans du ction ▁in ▁target ed ▁cells ), ▁which ▁is ▁important ▁for ▁ins ul in ▁secret ion ▁reg ulation . ▁ ▁The ▁function ▁of ▁the ▁H Y MA I ▁( h yd at iform ▁mole - associ ated ▁and ▁im print ed ▁trans cript ) ▁is ▁unknown . ▁ ▁Second , ▁chrom os ome ▁ 6 q 2 4 - T ND M ▁is ▁caused ▁by ▁over - expression ▁of ▁im print ed ▁gen es ▁at ▁ 6 q 2 4 ▁( P LA GL 1 ▁[ Z AC ] ▁and ▁H Y MA I ). ▁It ▁was ▁discovered ▁that ▁a ▁differential ly ▁m eth yl ated ▁region ▁( D MR ) ▁is ▁present ▁within ▁the ▁shared ▁prom oter ▁of ▁these ▁gen es . ▁Gener ally ▁the ▁expression ▁of ▁the ▁mother ' s ▁alle les ▁of ▁P