▁in ▁ 2 0 0 4 . ▁▁▁ ▁After ▁gradu ating , ▁she ▁went ▁to ▁the ▁University ▁of ▁Colorado ▁for ▁her ▁master ' s ▁degree . ▁ ▁Career ▁ ▁Academ ic ▁ ▁In ▁ 2 0 0 6 , ▁Wang ▁worked ▁as ▁a ▁lect urer ▁at ▁the ▁University ▁of ▁Wu han . ▁She ▁ ▁begin ▁working ▁on ▁her ▁th esis ▁about ▁pattern ▁recognition ▁signal ing ▁of ▁the ▁inn ate ▁imm une ▁system ▁as ▁it ▁rel ates ▁to ▁vir uses , ▁especially ▁in ▁regard ▁to ▁the ▁Type ▁ 1 ▁IF N ▁system , ▁which ▁acts ▁to ▁alert ▁the ▁imm une ▁system ▁to ▁vir al ▁in fection ▁and ▁in ▁specific ▁cases , ▁over react ▁to ▁the ▁virus , ▁causing ▁lung ▁infl amm ation ▁and ▁ac ute ▁resp ir atory ▁dist ress . ▁Part icular ly ▁her ▁study ▁involved ▁the ▁knock down ▁of ▁W DR 5 ▁ ▁in ▁order ▁to ▁see ▁if ▁it ▁in hib ited ▁virus - trigger ed ▁activation ▁of ▁IR F 3 ▁and ▁N F - kappa B , ▁as ▁well ▁as ▁trans cription ▁of ▁the ▁IF NB 1 ▁gene , ▁thereby ▁lower ing ▁the ▁imm une ▁response ▁which ▁could ▁result ▁in ▁over - infl amm ation ▁of ▁the ▁l ungs ▁and ▁thus ▁ac ute ▁resp ir atory ▁dist ress . ▁Her ▁find ings ▁in ▁ ▁this ▁study ▁was ▁that ▁W DR 5 ▁is ▁essential ▁in ▁assemb ling ▁a ▁virus - indu ced ▁V IS A - associ ated ▁complex ▁and ▁in ▁virus - trigger ed ▁induction ▁of ▁type ▁I ▁IF N s