▁p ump ▁in hib itors ▁( P PI s ), ▁which ▁are ▁effective ▁for ▁the ▁treatment ▁of ▁heart burn . ▁ ▁Trad itional ▁ther ap ies ▁used ▁for ▁this ▁diagn osis ▁include ▁l ifest yle ▁modification , ▁ant ac ids , ▁H 2 - re ceptor ▁ant agon ists ▁( H 2 - R As ), ▁pro kin etic ▁agents , ▁and ▁ant if lat ul ents . ▁It ▁ ▁has ▁been ▁noted ▁that ▁one ▁of ▁the ▁most ▁fr ustr ating ▁aspects ▁of ▁tre ating ▁functional ▁d ys pe ps ia ▁is ▁that ▁these ▁traditional ▁agents ▁have ▁been ▁shown ▁to ▁have ▁little ▁or ▁no ▁effic acy . ▁ ▁Ac id ▁supp ression ▁Ant ac ids ▁and ▁suc ral f ate ▁were ▁found ▁to ▁be ▁no ▁better ▁than ▁place bo ▁in ▁a ▁literature ▁review . ▁ ▁H 2 - R As ▁have ▁been ▁shown ▁to ▁have ▁marked ▁benefit ▁in ▁poor ▁quality ▁tri als ▁( 3 0 % ▁relative ▁risk ▁reduction ), ▁but ▁only ▁a ▁marg inal ▁benefit ▁in ▁good ▁quality ▁tri als . ▁Pro kin etic ▁agents ▁would ▁empir ically ▁seem ▁to ▁work ▁well ▁since ▁delayed ▁g astr ic ▁empty ing ▁is ▁considered ▁a ▁major ▁path oph ys i ological ▁mechanism ▁in ▁functional ▁d ys pe ps ia . ▁ ▁They ▁have ▁been ▁shown ▁in ▁a ▁meta - analysis ▁to ▁produce ▁a ▁relative ▁risk ▁reduction ▁of ▁up ▁to ▁ 5 0 %, ▁but ▁the ▁studies ▁evaluated ▁to ▁come ▁to ▁this ▁conclusion ▁used ▁the ▁drug ▁c is ap ride ▁which ▁has ▁since ▁been ▁removed ▁from