it ol ▁de ple tion ▁hypothesis , ▁research ers ▁have ▁shown ▁that ▁l ith ium ▁bind s ▁un comp et it ively ▁to ▁pur ified ▁b ov ine ▁I MP ase ▁at ▁the ▁site ▁of ▁one ▁of ▁the ▁mag nes ium ▁ ions . ▁Rod ents ▁admin ister ed ▁l ith ium ▁showed ▁a ▁decrease ▁in ▁in os it ol ▁levels , ▁in ▁line ▁with ▁the ▁hypothesis . ▁ ▁Val pro ate , ▁another ▁m ood - st abil izing ▁drug ▁given ▁to ▁b ip olar ▁dis order ▁patients , ▁has ▁also ▁been ▁shown ▁to ▁m im ic ▁the ▁effects ▁of ▁l ith ium ▁on ▁my o - inos it ol . ▁ ▁However , ▁some ▁clin ical ▁studies ▁have ▁found ▁that ▁b ip olar ▁dis order ▁patients ▁that ▁had ▁been ▁admin ister ed ▁l ith ium ▁showed ▁lower ▁my o - inos it ol ▁levels , ▁while ▁others ▁found ▁no ▁effect ▁on ▁my o - inos it ol ▁levels . ▁Furthermore , ▁l ith ium ▁also ▁bind s ▁to ▁in os it ol ▁poly ph osph ate ▁ 1 - ph osph at ase ▁( IP P ), ▁an ▁en zym e ▁also ▁present ▁in ▁the ▁ph osph o inos it ide ▁path way , ▁and ▁could ▁lower ▁in os it ol ▁levels ▁through ▁this ▁mechanism ▁More ▁research ▁is ▁required ▁to ▁fully ▁explain ▁the ▁role ▁that ▁l ith ium ▁and ▁I MP ase ▁play ▁in ▁b ip olar ▁dis order ▁patients . ▁ ▁Despite ▁the ▁fact ▁that ▁l ith ium ▁is ▁effective