▁evolution ary ▁relationship ▁between ▁imm une ▁response ▁systems ▁and ▁damage ▁repair ▁response ▁systems , ▁Se ong ▁proposed ▁the ▁presence ▁of ▁a ▁universal ▁mechanism ▁of ▁cell ular ▁response ▁to ▁injury ▁and ▁inst ig ation ▁of ▁repair . ▁ ▁In ▁his ▁study ▁of ▁hy pp os ▁and ▁the ▁D AMP s ▁model ▁Se ong ▁discovered ▁mole cules ▁term ed ▁" hy ppo - qu en ch ers " ▁which ▁prevent ▁init iation ▁of ▁imm une ▁responses ▁by ▁hy pp os ▁when ▁the ▁cell ▁is ▁not ▁in ▁normal ▁phys i ological ▁conditions . ▁Hy ppo - qu en ch ers ▁prevent ▁imm une ▁response ▁by ▁in hib iting ▁interaction ▁between ▁hy pp os ▁and ▁their ▁re cept ors . ▁In ▁studying ▁nuclear ▁factor - κ B ▁dependent ▁gene ▁expression ▁Se ong ▁found ▁strong ▁evidence ▁that ▁ap ol ip op rote ins ▁function ▁as ▁a ▁hy ppo - qu en cher . ▁When ▁exposed ▁to ▁high ▁hy ppo ▁levels , ▁cells ▁with ▁ap ol ip op rote ins ▁did ▁not ▁initi ate ▁imm une ▁responses ▁ev iden cing ▁their ▁role ▁as ▁a ▁hy ppo - qu en cher . ▁ ▁Se ong ▁has ▁continued ▁his ▁study ▁of ▁the ▁D AMP s ▁Model ▁with ▁his ▁research ▁on ▁the ▁role ▁of ▁D AMP s ▁and ▁hy pp os ▁in ▁several ▁infl am mat ory ▁dise ases . ▁In ▁particular , ▁his ▁lab ▁studies ▁the ▁role ▁of ▁hy pp os ▁in ▁Al z heimer ' s ▁disease , ▁se ps is , ▁ul cer ative ▁col itis ▁and ▁at op