▁led ▁by ▁the ▁By z antine ▁Emperor ▁most ▁inhabitants ▁fled ▁to ▁the ▁A ege an ▁coast ▁and ▁the ▁European ▁part ▁of ▁the ▁By z antine ▁Empire . ▁As ▁a ▁result ▁of ▁the ▁Turkish ▁invasion ▁in ▁the ▁region ▁and ▁the ▁destruction ▁of ▁the ▁city ▁the ▁area ▁was ▁largely ▁abandoned . ▁In ▁ 1 3 1 3 , ▁Man isa ▁became ▁a ▁permanent ▁Turkish ▁possession ▁when ▁taken ▁by ▁the ▁Bey lik ▁of ▁Sar u han , ▁led ▁by ▁the ▁Bey ▁of ▁the ▁same ▁name ▁who ▁had ▁started ▁out ▁as ▁a ▁trib ut ary ▁of ▁the ▁Sel ju ks ▁and ▁who ▁re igned ▁until ▁ 1 3 4 6 . ▁His ▁sons ▁held ▁the ▁region ▁until ▁ 1 3 9 0 , ▁when ▁the ▁first ▁incorpor ation ▁of ▁their ▁lands ▁into ▁the ▁expand ing ▁Ott oman ▁state ▁took ▁place . ▁After ▁a ▁brief ▁interval ▁caused ▁by ▁the ▁Ott oman ▁inter reg num ▁after ▁the ▁Battle ▁of ▁An k ara , ▁Man isa ▁and ▁its ▁surr ound ings ▁definitely ▁became ▁part ▁of ▁the ▁Ott oman ▁Empire ▁in ▁ 1 4 1 0 . ▁ ▁Even ▁during ▁the ▁ 1 5 th ▁century ▁Mag nes ia ▁was ▁recorded ▁as ▁being ▁in ▁complete ▁ru ins ▁due ▁to ▁the ▁previous ▁Turkish ▁ra ids . ▁As ▁the ▁central ▁town ▁of ▁the ▁Ott oman ▁Empire ' s ▁Sar u han ▁san jak , ▁the ▁city ▁became ▁the ▁training ▁ground ▁for ▁sh ah z ades ▁( c rown ▁princes ), ▁and ▁it ▁stood ▁out ▁as ▁one ▁of ▁the ▁wealth iest ▁parts ▁of ▁the