▁mi R - 2 1 4 , ▁along ▁with ▁its ▁cluster ▁mate ▁mi R - 1 9 9 , ▁has ▁been ▁shown ▁to ▁be ▁imp licated ▁in ▁ske leton ▁formation . ▁mi R - 2 1 4 ▁has ▁been ▁shown ▁to ▁in hib it ▁b one ▁formation ▁in ▁human ▁cell ▁lines ▁both ▁by ▁target ing ▁A TF 4 , ▁a ▁gene ▁encoding ▁one ▁of ▁the ▁main trans cription ▁factors ▁required ▁for ▁o ste ob last ▁function ▁and ▁by ▁suppress ing ▁o ste ogen ic ▁different iation ▁of ▁C 2 C 1 2 ▁my ob last ▁cells ▁by ▁target ing ▁Sp 7 , ▁an ▁o ste ob last - specific ▁trans cription ▁factor . ▁Also , ▁Tw ist - 1 , ▁which ▁is ▁a ▁major ▁actor ▁in ▁ske leton ▁formation , ▁regul ates ▁mi R - 1 9 9 ▁and ▁mi R - 2 1 4 ▁cluster ▁expression ▁in ▁mouse . ▁Furthermore , ▁mi R 1 9 9 - 2 1 4 ▁cluster ▁delet ion ▁in ▁mouse ▁lead ▁to ▁ske let al ▁development ▁ab normal ities ▁including ▁c ran io fa cial ▁defect s , ▁neural ▁arch ▁and ▁spin ous ▁processes ▁mal form ations , ▁and ▁o ste open ia . ▁In ▁z eb raf ish , ▁mi R - 2 1 4 ▁expression ▁is ▁mainly ▁observed ▁around ▁developing ▁ske let al ▁elements . ▁ ▁References ▁▁ ▁Category : M icro R NA <0x0A> </s> ▁You ▁Br ing ▁Me ▁Joy ▁may ▁refer ▁to : ▁▁ ▁" You ▁Br ing ▁Me ▁Joy ", ▁a ▁song