loc ate ▁to ▁the ▁host ▁cell ▁nucle us , ▁where ▁a ▁vir ally ▁encoded ▁DNA ▁polym er ase ▁facil it ates ▁DNA ▁rep lication . ▁ ▁Vir al ▁DNA ▁then ▁leaves ▁the ▁nucle us ▁of ▁the ▁host ▁cell ▁and ▁a ▁second ▁stage ▁of ▁DNA ▁rep lication ▁occurs ▁in ▁the ▁cy top las m , ▁forming ▁DNA ▁conc atem ers . ▁ ▁A ▁head ful ▁mechanism ▁is ▁util ized ▁to ▁package ▁the ▁conc at amer ic ▁vir al ▁DNA ▁into ▁vir ions ▁formed ▁at ▁cy top las mic ▁virus ▁assembly ▁sites . ▁I rid ov iral ▁DNA , ▁unlike ▁other ▁DNA ▁vir uses ▁inf ect ing ▁e uk ary otic ▁cells , ▁is ▁circular ly ▁perm uted ▁and ▁exhib its ▁terminal ▁redund an cies . ▁ ▁Trans mission ▁and ▁ep izo ology ▁ ▁Trans mission ▁of ▁meg al oc yt iv irus ▁is ▁believed ▁to ▁occur ▁when ▁a ▁na ive ▁fish ▁ing ests ▁t issues ▁from ▁inf ected ▁fish ▁or ▁via ▁cont amin ated ▁water . ▁ ▁Consider able ▁effort ▁has ▁been ▁exp ended ▁to ▁understand ▁the ▁transmission ▁and ▁ep izo ology ▁of ▁meg al oc yt iv ir uses ▁because ▁of ▁the ▁economic ▁importance ▁of ▁commercial ▁fish eries ▁and ▁aqu ac ulture ▁operations . ▁ ▁I rid ov iral ▁ep iz oot ics ▁do ▁not ▁correlate ▁well ▁with ▁commercial ▁food ▁fish ▁trade ▁routes , ▁with ▁the ▁notable ▁exception ▁of ▁lar val ▁fish ▁trade ▁in ▁Korea ▁and ▁Japan . ▁ ▁A ▁second ▁potential ▁mechanism ▁for ▁accident al ▁movement ▁of ▁inf ected ▁fish ▁is ▁the