▁cle av age ▁system ▁is ▁found ▁in ▁the ▁ad ren al ▁cor tex ▁and ▁the ▁cor pus ▁l ute um . ▁The ▁system ▁is ▁also ▁expressed ▁at ▁high ▁levels ▁in ▁ster oid ogen ic ▁the ca ▁cells ▁in ▁the ▁ov ary , ▁and ▁Le yd ig ▁cells ▁in ▁the ▁test is . ▁During ▁pre gn ancy , ▁the ▁pla cent a ▁also ▁express es ▁significant ▁levels ▁of ▁this ▁en zym e ▁system . ▁P 4 5 0 s cc ▁is ▁also ▁present ▁at ▁much ▁lower ▁levels ▁in ▁several ▁other ▁t issue ▁types , ▁including ▁the ▁brain . ▁ ▁In ▁the ▁ad ren al ▁cor tex , ▁the ▁concentration ▁of ▁ad ren odox in ▁is ▁similar ▁to ▁that ▁of ▁P 4 5 0 s cc , ▁but ▁ad ren odox in ▁re duct ase ▁is ▁expressed ▁at ▁lower ▁levels . ▁ ▁Im mun of lu ores c ence ▁studies ▁using ▁specific ▁ant ib od ies ▁against ▁P 4 5 0 s cc ▁system ▁en zym es ▁have ▁demonstrated ▁that ▁prote ins ▁are ▁located ▁exclus ively ▁within ▁the ▁mit och ond ria . ▁P 4 5 0 s cc ▁is ▁associated ▁with ▁the ▁inner ▁mit och ond rial ▁memb rane , ▁facing ▁the ▁interior ▁( matrix ). ▁Ad ren odox in ▁and ▁ad ren odox in ▁re duct ase ▁are ▁sol ub le ▁peri pher al ▁memb rane ▁prote ins ▁located ▁inside ▁the ▁mit och ond rial ▁matrix ▁that ▁appear ▁to ▁associate ▁with ▁each ▁other ▁primarily ▁through ▁electro static ▁interactions . ▁ ▁Mechan ism ▁of