er ▁synd rome ▁type ▁IC ▁is ▁the ▁NUM T . ▁No ▁certain ▁cur se ▁has ▁yet ▁found ▁for ▁U sh er ▁synd rome , ▁however , ▁a ▁current ▁clin ical ▁study ▁on ▁ 1 8 ▁volunte ers ▁is ▁taking ▁place ▁to ▁determine ▁the ▁influence ▁of ▁U sh Stat ▁both ▁in ▁a ▁short ▁and ▁a ▁long - term ▁period . ▁This ▁study ▁has ▁been ▁started ▁in ▁September ▁ 2 0 1 3 ▁and ▁is ▁estimated ▁to ▁be ▁done ▁by ▁October ▁ 2 0 2 3 . ▁ ▁A ging : ▁Several ▁studies ▁indicated ▁that ▁de ▁nov o ▁appearance ▁of ▁NUM T ▁pseud ogen es ▁in ▁the ▁gen ome ▁of ▁som atic ▁cells ▁may ▁be ▁of ▁et i ological ▁importance ▁for ▁car cin ogen esis ▁and ▁ag ing . ▁To ▁show ▁the ▁relation ▁between ▁ag ing ▁and ▁NUM T ▁in ▁the ▁nuclear ▁gen ome , ▁Ch eng ▁and ▁I v essa ▁used ▁y me 1 - 1 ▁mut ant ▁stra ins ▁of ▁Sac char omy ces ▁C ere vis iae ▁that ▁have ▁a ▁higher ▁rate ▁of ▁m t D NA ▁migration . ▁The ▁method ▁is ▁exactly ▁the ▁same ▁as ▁the ▁method ▁Th ors ness ▁and ▁Fox ▁used ▁to ▁determine ▁the ▁important ▁mechan isms ▁and ▁factors ▁for ▁m t D NA ▁migration ▁into ▁the ▁nucle us . ▁They ▁found ▁out ▁the ▁ye ast ▁stra ins ▁with ▁elev ated ▁migration ▁rates ▁of ▁m t D NA ▁fragments ▁to ▁the ▁nucle us ▁showed ▁acceler ated ▁chron ological ▁ag ing , ▁whereas , ▁stra ins ▁with ▁decre ased ▁m