▁Con us ▁l yn ce us . ▁It ▁diff ers ▁from ▁Con - R ▁mainly ▁in ▁the ▁C - term inal ▁am ino ▁ac ids ▁and , ▁like ▁Con - R , ▁it ▁indu ces ▁sleep - like ▁sympt oms ▁in ▁young ▁m ice , ▁with ▁faster ▁on set ▁and ▁for ▁a ▁longer ▁duration . ▁ ▁Con - L ▁blocks ▁N MD A - ev oked ▁curr ents ▁in ▁a ▁powerful ▁way , ▁which ▁is ▁only ▁slowly ▁revers ible ▁upon ▁was h out , ▁similar ▁to ▁Con - R ▁and ▁Con - G . ▁ ▁Con ant ok in - Pr 1 , ▁- Pr 2 ▁and ▁– Pr 3 ▁ ▁Each ▁pe pt ide ▁in ▁this ▁group ▁is ▁derived ▁from ▁the ▁same ▁species , ▁Con us ▁par ius . ▁Con - Pr 3 ▁() ▁has ▁three ▁different ▁post - trans l ational ▁modifications . ▁Con - Pr 1 ▁() ▁and ▁– Pr 2 ▁() ▁adopt ▁α - hel ical ▁conform ations ▁in ▁the ▁presence ▁of ▁M g 2 + ▁and ▁Ca 2 + , ▁but ▁otherwise ▁are ▁generally ▁un struct ured . ▁Con ant ok in - Pr 3 ▁always ▁adopt s ▁an ▁α - hel ical ▁con formation . ▁ ▁These ▁pe pt ides ▁have ▁highest ▁pot ency ▁for ▁the ▁NR 2 B ▁sub un its ▁of ▁the ▁N MD AR . ▁ ▁Con ant ok in - P ▁and ▁- E ▁ ▁Con - P ▁() ▁and ▁Con - E ▁() ▁were ▁isolated ▁from ▁the ▁only ▁two ▁fish - h