ops ▁who ▁were ▁une asy ▁with ▁the ▁language ▁of ▁Pope ▁Leo ' s ▁T ome ▁rep udi ated ▁the ▁council , ▁saying ▁that ▁the ▁accept ance ▁of ▁two ▁phys es ▁was ▁tant amount ▁to ▁N est or ian ism . ▁Dios cor us ▁of ▁Alexand ria ▁advoc ated ▁m ia phys it ism ▁and ▁had ▁domin ated ▁the ▁Council ▁of ▁E ph es us . ▁Church es ▁that ▁rejected ▁Chal ced on ▁in ▁favor ▁of ▁E ph es us ▁broke ▁off ▁from ▁the ▁rest ▁of ▁the ▁Eastern ▁Church ▁in ▁a ▁sch ism , ▁the ▁most ▁significant ▁among ▁these ▁being ▁the ▁Church ▁of ▁Alexand ria , ▁today ▁known ▁as ▁the ▁Co ptic ▁Orth odox ▁Church ▁of ▁Alexand ria . ▁The ▁rise ▁of ▁the ▁" so - called " ▁Mon oph ys it ism ▁in ▁the ▁East ▁( as ▁brand ed ▁by ▁the ▁West ) ▁was ▁led ▁by ▁the ▁Co pts ▁of ▁Egypt . ▁This ▁must ▁be ▁regarded ▁as ▁the ▁out ward ▁expression ▁of ▁the ▁growing ▁national ist ▁tr ends ▁in ▁that ▁province ▁against ▁the ▁grad ual ▁intens ification ▁of ▁By z antine ▁imperial ism , ▁soon ▁to ▁reach ▁its ▁consum m ation ▁during ▁the ▁reign ▁of ▁Emperor ▁Justin ian . ▁A ▁significant ▁effect ▁on ▁the ▁Orth odox ▁Christians ▁in ▁Egypt , ▁was ▁a ▁series ▁of ▁per sec utions ▁by ▁the ▁Roman ▁( l ater , ▁By z antine ) ▁emp ire ▁forcing ▁follow ers ▁of ▁the ▁Eastern ▁Orth odox ▁Church ▁to ▁claim ▁alleg iance ▁to ▁Leo ' s ▁T ome , ▁or ▁Chal ced