▁and ▁research ▁institutions , ▁and ▁subsequently ▁en hanced ▁different ▁parts ▁of ▁the ▁Ros etta ▁project . ▁ ▁Ros etta Des ign ▁▁ ▁Ros etta Des ign , ▁a ▁computing ▁approach ▁to ▁protein ▁design ▁based ▁on ▁Ros etta , ▁began ▁in ▁ 2 0 0 0 ▁with ▁a ▁study ▁in ▁red es ign ing ▁the ▁fol ding ▁path way ▁of ▁Prote in ▁G . ▁In ▁ 2 0 0 2 ▁Ros etta Des ign ▁was ▁used ▁to ▁design ▁Top 7 , ▁a ▁ 9 3 - am ino ▁acid ▁long ▁α / β ▁protein ▁that ▁had ▁an ▁overall ▁fol d ▁never ▁before ▁recorded ▁in ▁nature . ▁ ▁This ▁new ▁con formation ▁was ▁predicted ▁by ▁Ros etta ▁to ▁within ▁ 1 . 2   Å ▁R MS D ▁of ▁the ▁structure ▁determined ▁by ▁X - ray ▁cry stal log raph y , ▁representing ▁an ▁unus ually ▁accurate ▁structure ▁prediction . ▁Ros etta ▁and ▁Ros etta Des ign ▁earned ▁w ides p read ▁recognition ▁by ▁being ▁the ▁first ▁to ▁design ▁and ▁accur ately ▁predict ▁the ▁structure ▁of ▁a ▁novel ▁protein ▁of ▁such ▁length , ▁as ▁reflected ▁by ▁the ▁ 2 0 0 2 ▁paper ▁describing ▁the ▁dual ▁approach ▁prompt ing ▁two ▁positive ▁letters ▁in ▁the ▁journal ▁Science , ▁and ▁being ▁c ited ▁by ▁more ▁than ▁ 2 4 0 ▁other ▁scientific ▁articles . ▁The ▁visible ▁product ▁of ▁that ▁research , ▁Top 7 , ▁was ▁featured ▁as ▁the ▁RC SB ▁P DB ' s ▁' M ole c ule ▁of ▁the ▁Month ' ▁in ▁October ▁ 2