▁ ▁The ▁AA ▁protein ▁is ▁mainly ▁depos ited ▁in ▁the ▁li ver , ▁s ple en ▁and ▁kid ney , ▁and ▁AA ▁am y lo idos is ▁can ▁lead ▁to ▁ne ph rot ic ▁synd rome ▁and ▁E SR D . ▁Natural ▁history ▁studies ▁show , ▁however , ▁that ▁it ▁is ▁the ▁kid ney ▁invol vement ▁that ▁drives ▁the ▁pro gression ▁of ▁the ▁disease . ▁In ▁general , ▁old ▁age , ▁reduced ▁ser um ▁album in ▁concentration , ▁end ▁stage ▁kid ney ▁failure , ▁and ▁sust ained ▁elev ated ▁S AA ▁concentration ▁are ▁all ▁associated ▁with ▁poor ▁pro gn osis . ▁ ▁There ▁are ▁currently ▁no ▁approved ▁treat ments ▁for ▁system ic ▁AA ▁am y lo idos is . ▁The ▁current ▁standard ▁of ▁care ▁includes ▁treat ments ▁for ▁the ▁underlying ▁infl am mat ory ▁disease ▁with ▁anti - infl am mat ory ▁dru gs , ▁imm unos upp ress ive ▁agents ▁or ▁bi olog ics . ▁AA ▁am y lo idos is ▁patients ▁are ▁also ▁receiving ▁treat ments ▁to ▁slow ▁down ▁the ▁decl ine ▁of ▁their ▁ren al ▁function , ▁such ▁as ▁ang iot ens in ▁II ▁re ceptor ▁block ers ▁or ▁ang iot ens in ▁converting ▁en zym e ▁in hib itors . ▁ ▁Trans mission ▁of ▁am y lo idos is ▁There ▁is ▁evidence ▁that ▁e ating ▁am y lo id ▁fib ers ▁may ▁lead ▁to ▁am y lo idos is . ▁This ▁evidence ▁is ▁based ▁on ▁studies ▁in ▁cattle , ▁ch ick ens , ▁m ice , ▁and ▁che et