atic ▁cancer , ▁gall st ones ▁ ▁Se vere ▁hem ol ysis , ▁e . g ., ▁some ▁heart ▁val ves ▁ ▁Gilbert ' s ▁synd rome ▁with ▁high ▁un con j ug ated ▁hyper bil ir ub in emia ▁ ▁Ac ute ▁infl am mat ory ▁synd rome ▁( the ▁blood ▁test ▁may ▁be ▁post pon ed ) ▁ ▁Inter pret ation ▁ ▁The ▁conversion ▁of ▁F ib ro Test ▁score ▁into ▁stages ▁according ▁to ▁the ▁three ▁most ▁used ▁hist ological ▁class ifications ▁( ME TA V IR , ▁Kn od ell ▁and ▁I sh ak ) ▁for ▁li ver ▁bi ops ies ▁is : ▁ ▁Com parison ▁with ▁li ver ▁bi ops y ▁Liver ▁bi ops y ▁is ▁an ▁imper fect ▁tool ; ▁due ▁to ▁sampling ▁errors , ▁bi ops y ▁size ▁( 5 ▁to ▁ 3 0   mm ) ▁and ▁int ra - ▁and ▁inter observ or ▁vari ability , ▁it ▁is ▁now ▁agreed ▁that ▁bi ops y ▁is ▁an ▁" imper fect ▁Gold ▁Standard ▁ ▁" ▁( c itation ▁required ). ▁ ▁Bi ops y ▁continues ▁to ▁present ▁incon ven ien ces : ▁ 3 0 % ▁of ▁patients ▁comp lain ▁of ▁pain , ▁up ▁to ▁ 3 % ▁have ▁been ▁noted ▁to ▁have ▁comp lications ▁severe ▁enough ▁to ▁require ▁hospital ization ▁and ▁a ▁ 0 . 0 1 - 0 . 3 % ▁rate ▁of ▁death s ▁has ▁been ▁reported . There ▁is ▁a ▁mean ▁disc ord ance ▁of ▁ 2 5 % ▁between ▁F ib ro