- 1 ▁integr in ) ▁is ▁local ized ▁to ▁Z - dis cs ▁and ▁cost am ere ▁structures , ▁bound ▁to ▁the ▁four ▁and ▁one ▁half ▁LIM ▁domain ▁prote ins , ▁F HL 1 ▁and ▁F HL 2 . ▁It ▁has ▁been ▁demonstrated ▁that ▁alpha - 7 ▁integr in ▁can ▁be ▁mon o - AD P - rib os yl ated ▁on ▁the ▁cell ▁surface ▁in ▁ske let al ▁mus cle ▁cells ; ▁however , ▁the ▁functional ▁significance ▁of ▁this ▁modification ▁has ▁not ▁been ▁investig ated . ▁ ▁Ins ights ▁into ▁the ▁function ▁of ▁alpha - 7 ▁integr in ▁have ▁come ▁from ▁studies ▁employ ing ▁mouse ▁trans gen esis . ▁A ▁mouse ▁express ing ▁a ▁null ▁alle le ▁of ▁the ▁IT GA 7 ▁gene ▁are ▁vi able , ▁suggesting ▁that ▁alpha - 7 ▁integr in ▁is ▁not ▁essential ▁for ▁normal ▁my ogen esis ; ▁however , ▁these ▁m ice ▁develop ▁a ▁phen ot ype ▁that ▁res emb les ▁mus cular ▁d yst ro phy . ▁In ▁sole us ▁mus cle , ▁there ▁was ▁a ▁significant ▁dis ruption ▁of ▁my ot end in ous ▁j unction s , ▁variation ▁in ▁the ▁size ▁of ▁fib ers , ▁cent r ally ▁located ▁nuc lei , ▁ne c ros is , ▁ph ag oc yt osis , ▁and ▁elev ated ▁ser um ▁levels ▁of ▁cre at ine ▁kin ase . ▁It ▁has ▁also ▁been ▁proposed ▁that ▁alpha - 7 ▁integr in ▁and ▁g amma - s arc og ly can ▁have ▁over la pping ▁functions ▁in ▁ske