▁gran ules ▁of ▁P ML s . ▁ ▁Str ucture ▁ ▁As ▁with ▁most ▁P GR P s , ▁P GL Y R P 1 ▁has ▁one ▁car box y - term inal ▁type ▁ 2 ▁amid ase ▁domain ▁( also ▁known ▁as ▁a ▁P GR P ▁domain ) ▁and ▁consists ▁of ▁three ▁alpha ▁hel ices , ▁five ▁beta ▁str ands ▁and ▁co ils , ▁and ▁has ▁three ▁pairs ▁of ▁conser ved ▁c yst e ins ▁which ▁form ▁three ▁dis ul ph ide ▁b onds . ▁ ▁P GL Y R P 1 ▁can ▁form ▁hom od im ers ▁for ▁its ▁ant im icro b ial ▁activity , ▁and ▁can ▁complex ▁with ▁H SP 7 0 ▁for ▁its ▁c yt ot ox ic ▁activity . ▁ ▁Function ▁ ▁The ▁P GL Y R P 1 ▁protein ▁plays ▁an ▁important ▁role ▁in ▁the ▁inn ate ▁imm une ▁response . ▁ ▁It ▁is ▁b acter ic idal ▁against ▁gram - pos itive ▁b acter ia ▁such ▁as ▁S . ▁a ure us , ▁S . ▁e pid erm id is , ▁and ▁L . ▁mon oc yt ogen es ▁and ▁generally ▁has ▁pro infl am mat ory ▁effects , ▁indu cing ▁T NF - a ▁and ▁IF N - g ▁in ▁many ▁t issues . ▁ ▁P GL Y R P - 1 ▁is ▁also ▁known ▁to ▁form ▁a ▁c yt ot ox ic ▁complex ▁with ▁H SP - 7 0 , ▁suggesting ▁it ▁may ▁also ▁have ▁a ▁role ▁in ▁anti - can cer ▁defense