▁in ▁o ste ob last s , ▁so ▁if ▁the ▁reg ulation ▁did ▁not ▁occur ▁it ▁consequ ently ▁leads ▁to ▁s cl eros is . ▁ ▁Even ▁though ▁Th rom box ane - A ▁synth ase ▁is ▁important ▁for ▁plate let ▁aggreg ation ▁it ▁is ▁important ▁to ▁note ▁that ▁patients ▁with ▁this ▁disease ▁do ▁not ▁suffer ▁from ▁any ▁ble eding ▁problems . ▁ ▁The ▁ref ract ory ▁an emia ▁also ▁called ▁cort ic ost ero id ▁sensitive ▁an emia , ▁is ▁likely ▁due ▁to ▁fib rot ic ▁sc arring ▁or ▁s cl eros is , ▁which ▁is ▁the ▁st iff ening ▁of ▁the ▁t issue ▁when ▁organ - specific ▁t issue ▁is ▁replaced ▁with ▁connect ive ▁t issue . ▁Th rom box ane - A ▁synth ase ▁also ▁participants ▁in ▁the ▁a rach id onic ▁acid ▁met abol ism ▁path way , ▁which ▁has ▁effects ▁on ▁the ▁prost ag land in ▁E 2 ▁levels . ▁A ▁decrease ▁in ▁Th rom box ane - A ▁synth ase ▁leads ▁to ▁an ▁increase ▁in ▁prost ag land in ▁E 2 ▁levels ▁which ▁may ▁affect ▁er yth roid ▁prec ursor ▁cells ▁by ▁suppress ing ▁them ▁which ▁likely ▁leads ▁to ▁ref ract ory ▁an emia . ▁ ▁There ▁are ▁still ▁un answer ed ▁questions ▁about ▁the ▁effect ▁of ▁a ▁comprom ised ▁T B X AS 1 ▁gene ▁function ▁and ▁its ▁affect ▁in ▁Gh os al ▁h emat odia phy se al ▁d ys pl asia . ▁ ▁Tre at ment ▁ ▁Blood ▁trans f us ions ▁can ▁treat