▁Cab ot ▁confirmed ▁that ▁the ▁Amer ind ians ▁were ▁about ▁to ▁attack ▁the ▁fort , ▁but ▁continued ▁to ▁the ▁north , ▁trust ing ▁that ▁Car o ▁would ▁be ▁able ▁to ▁defend ▁it . ▁The ▁attack ▁came ▁on ▁the ▁night ▁of ▁September ▁ 1 , ▁ 1 5 2 9 . ▁The ▁Amer ind ians ▁set ▁the ▁fort ▁on ▁fire ▁while ▁all ▁the ▁soldiers ▁were ▁sleep ing . ▁When ▁they ▁w oke ▁up , ▁real izing ▁defense ▁would ▁be ▁useless , ▁they ▁tried ▁to ▁board ▁the ▁two ▁ships ▁and ▁fle e . ▁Most ▁of ▁them ▁were ▁killed ▁and ▁one ▁of ▁the ▁ships ▁was ▁destroyed ▁before ▁it ▁could ▁leave . ▁▁ ▁The ▁surv iv ors ▁joined ▁Cab ot ▁and ▁García ▁who ▁immediately ▁returned ▁to ▁help . ▁By ▁the ▁time ▁they ▁returned , ▁all ▁remaining ▁Sp ani ards ▁were ▁dead , ▁and ▁the ▁fort ▁had ▁been ▁burn ed ▁and ▁raz ed ▁to ▁the ▁ground . ▁Comple t ely ▁defeated , ▁they ▁left ▁the ▁Amer icas ▁and ▁returned ▁to ▁Europe . ▁ ▁Con sequ ences ▁The ▁destruction ▁of ▁San ct i ▁Sp ir itu ▁ended ▁the ▁period ▁of ▁Spanish ▁expl oration ▁of ▁Argentina , ▁leading ▁to ▁the ▁period ▁of ▁colon ization . ▁The ▁rum ors ▁of ▁the ▁White ▁King ▁and ▁the ▁silver ▁mountain ▁continued ▁to ▁ ▁raise ▁interest ▁in ▁Spain ▁and ▁Portugal . ▁Spain ▁sent ▁Pedro ▁de ▁M endo za ▁to ▁colon ize ▁the ▁area ▁before ▁Portugal ▁could ▁do ▁so . ▁This ▁led ▁to ▁the ▁establishment ▁of ▁the ▁city ▁of ▁Buenos ▁Aires , ▁near ▁the ▁mouth ▁of