ot ers ▁( 2 0 . 7 ▁months ▁surv ival ). ▁ ▁The ▁W R N ▁gene ▁prom oter ▁is ▁hyper m eth yl ated ▁in ▁about ▁ 3 8 % ▁of ▁col ore ct al ▁can cers . ▁ ▁Ir in ot ec an ▁in activ ation ▁of ▁T OP 1 ▁may ▁be ▁synth et ically ▁le th al ▁with ▁def ic ient ▁expression ▁of ▁DNA ▁repair ▁gene ▁M RE 1 1 . ▁ ▁A ▁recent ▁study ▁was ▁carried ▁out ▁with ▁ 1 , 2 6 4 ▁patients ▁with ▁stage ▁III ▁colon ▁cancer . ▁ ▁The ▁patients ▁were ▁treated ▁with ▁a ▁post oper ative ▁week ly ▁adj uv ant ▁bol us ▁of ▁ 5 - flu or ou rac il / le uc ov or in ▁( F U / L V ) ▁or ▁else ▁with ▁ir in ot ec an + F U / L V ▁and ▁were ▁followed ▁up ▁for ▁ 8 ▁years . ▁ ▁Ele ven ▁percent ▁of ▁the ▁tum ors ▁were ▁def ic ient ▁for ▁DNA ▁repair ▁en zym e ▁M RE 1 1 ▁due ▁to ▁a ▁delet ion ▁of ▁a ▁string ▁of ▁th ym id ines ▁in ▁the ▁DNA ▁sequence ▁of ▁the ▁M RE 1 1 ▁gene . ▁ ▁The ▁addition ▁of ▁ir in ot ec an ▁to ▁F U / L V ▁in ▁the ▁treatment ▁protocol ▁resulted ▁in ▁M RE 1 1 - def ic ient ▁patients ▁having ▁better ▁long - term ▁disease ▁free ▁surv ival ▁than ▁patients ▁with ▁wild - type ▁M RE 1 1