▁County ▁Court . ▁ ▁He ▁em igr ated ▁to ▁Canada ▁in ▁ 1 8 6 3 . ▁ ▁Notable ▁buildings ▁ ▁Lamb eth ▁Mag istr ates ▁Court , ▁London ▁( 1 8 6 9 ) ▁ ▁Mount ▁Stephen ▁House , ▁a ▁hotel ▁in ▁Field , ▁British ▁Columbia ▁( 1 8 8 6 ) ▁ ▁References ▁ ▁Category : 1 8 3 6 ▁birth s ▁Category : 1 9 2 4 ▁death s ▁Category : Arch itect s ▁from ▁York shire ▁Category : Can ad ian ▁architect s ▁Category : Pe ople ▁from ▁W ake field ▁Category : B rit ish ▁em igr ants ▁to ▁Canada <0x0A> </s> ▁Th re on ine ▁prote ases ▁are ▁a ▁family ▁of ▁prote ol yt ic ▁en zym es ▁har bour ing ▁a ▁thre on ine ▁( T hr ) ▁resid ue ▁within ▁the ▁active ▁site . ▁The ▁prototype ▁members ▁of ▁this ▁class ▁of ▁en zym es ▁are ▁the ▁catal yt ic ▁sub un its ▁of ▁the ▁prote as ome , ▁however ▁the ▁a cy l trans fer ases ▁conver g ently ▁evol ved ▁the ▁same ▁active ▁site ▁geometry ▁and ▁mechanism . ▁ ▁Mechan ism ▁ ▁Th re on ine ▁prote ases ▁use ▁the ▁secondary ▁alco hol ▁of ▁their ▁N - term inal ▁thre on ine ▁as ▁a ▁nucle oph ile ▁to ▁perform ▁catal ysis . ▁The ▁thre on ine ▁must ▁be ▁N - term inal ▁since ▁the ▁terminal ▁am ine ▁of ▁the ▁same ▁resid ue ▁acts ▁as ▁a ▁general ▁base ▁by ▁polar ising ▁an ▁ordered ▁water ▁which