▁End ". ▁ ▁Char acters ▁ ▁Main ▁ ▁Jason ▁G ide on ▁( M andy ▁Pat ink in ), ▁senior ▁super vis ory ▁special ▁agent ▁and ▁former ▁B AU ▁unit ▁chief ▁( se asons ▁ 1 – 3 ) ▁ ▁G ide on ▁is ▁widely ▁known ▁as ▁the ▁B AU ' s ▁best ▁profil er . ▁After ▁a ▁series ▁of ▁em otion ally ▁trou bling ▁cases ▁and ▁the ▁murder ▁of ▁his ▁friend ▁Sarah ▁by ▁fug itive ▁serial ▁k iller ▁Frank ▁Bre it k opf ▁( Ke ith ▁Car rad ine ), ▁he ▁begins ▁to ▁feel ▁burn ed ▁out . ▁The ▁last ▁st raw ▁occurs ▁when ▁Unit ▁Chief ▁A aron ▁Hot ch ner ▁is ▁susp ended ▁for ▁two ▁weeks ▁by ▁the ▁team ' s ▁b oss — an ▁action ▁for ▁which ▁Jason ▁feels ▁responsible . ▁He ▁retre ats ▁to ▁his ▁cabin ▁and ▁leaves ▁a ▁letter ▁for ▁Dr . ▁Sp encer ▁Re id , ▁who ▁he ▁knows ▁will ▁be ▁the ▁one ▁to ▁look ▁for ▁him . ▁When ▁Sp encer ▁arriv es ▁at ▁the ▁cabin , ▁he ▁finds ▁the ▁letter ▁and ▁Jason ' s ▁F BI ▁credentials ▁and ▁fire arm . ▁Jason ▁is ▁last ▁seen ▁remark ing ▁to ▁a ▁Nev ada ▁din er ▁wait ress ▁that ▁he ▁does ▁not ▁know ▁where ▁he ▁is ▁going ▁or ▁how ▁he ▁will ▁know ▁when ▁he ▁gets ▁there , ▁leaving ▁the ▁din er ▁and ▁driving ▁off . ▁In ▁season ▁ 1 0 , ▁he ▁is ▁killed ▁( off - screen ) ▁by ▁a ▁suspect ▁he ▁had ▁track ed ▁down ▁from ▁one