▁the ▁other ▁gel atin ase ▁( M MP - 9 ) ▁has ▁been ▁associated ▁with ▁sever ity ▁of ▁chron ic ▁air way ▁dise ases ▁including ▁Id iop ath ic ▁inter st it ial ▁p neum onia ▁and ▁Bron ch ie ct asis . ▁In ▁id iop ath ic ▁inter st it ial ▁p neum onia , ▁M MP - 2 ▁activity ▁was ▁elev ated ▁in ▁patients ▁with ▁the ▁less ▁severe ▁disease ▁phen ot ype ▁which ▁is ▁more ▁respons ive ▁and ▁revers ible ▁with ▁cort ic ost ero id ▁ther apy . ▁In ▁non - c yst ic ▁fib ros is ▁bron ch ie ct asis , ▁M MP - 2 ▁concentration ▁was ▁elev ated ▁in ▁patients ▁with ▁Ha em oph ilus ▁influen za e ▁air way ▁in fection ▁compared ▁to ▁Pseud omon as ▁aer ugin osa ▁air way ▁in fection . ▁Bron ch ie ct asis ▁patients ▁with ▁P . ▁aer ugin osa ▁in fection ▁have ▁a ▁more ▁rapid ▁decl ine ▁in ▁lung ▁function . ▁ ▁Alter ed ▁expression ▁and ▁activity ▁levels ▁of ▁M MP s ▁have ▁been ▁strongly ▁imp licated ▁in ▁the ▁pro gression ▁and ▁met ast asis ▁of ▁many ▁forms ▁of ▁cancer . ▁In cre ased ▁M MP - 2 ▁activity ▁has ▁also ▁been ▁linked ▁with ▁a ▁poor ▁pro gn osis ▁in ▁multiple ▁forms ▁of ▁cancer ▁including ▁col ore ct al , ▁mel an oma , ▁breast , ▁lung , ▁o var ian , ▁and ▁pro state . ▁Furthermore , ▁changes ▁in ▁M MP - 2 ▁activity ▁can ▁come ▁from ▁alter