yt osis . ▁In ▁both ▁kinds ▁of ▁end oc yt osis , ▁it ▁has ▁long ▁been ▁known ▁that ▁act in ▁local izes ▁to ▁sites ▁of ▁ves icle ▁inv ag ination ▁and ▁is ▁a ▁vital ▁part ▁of ▁the ▁end oc yt ic ▁path way , ▁but ▁the ▁actual ▁mechan isms ▁by ▁which ▁act in ▁facil it ates ▁end oc yt osis ▁are ▁still ▁unclear . ▁Rec ently , ▁however , ▁it ▁has ▁been ▁found ▁that ▁dynam in , ▁the ▁protein ▁responsible ▁for ▁breaking ▁the ▁newly ▁formed ▁ves icular ▁bud ▁off ▁the ▁inside ▁of ▁the ▁pl asma ▁memb rane , ▁can ▁associate ▁with ▁the ▁SH 3 ▁domain ▁of ▁cort act in . ▁Since ▁cort act in ▁rec ruits ▁the ▁Ar p 2 / 3 ▁complex es ▁that ▁lead ▁to ▁act in ▁polym er ization , ▁this ▁suggests ▁that ▁it ▁may ▁play ▁an ▁important ▁part ▁in ▁linking ▁ves icle ▁formation ▁to ▁the ▁as ▁yet ▁unknown ▁functions ▁act in ▁has ▁in ▁end oc yt osis . ▁ ▁C lin ical ▁significance ▁▁ ▁Am pl ification ▁of ▁the ▁gen es ▁encoding ▁cort act in — in ▁humans , ▁E MS 1 — has ▁been ▁found ▁to ▁occur ▁in ▁certain ▁tum ors . ▁Over expression ▁of ▁cort act in ▁can ▁lead ▁to ▁highly - active ▁l am el lip odia ▁in ▁tum or ▁cells , ▁dub bed ▁“ inv ad op odia .” ▁These ▁cells ▁are ▁especially ▁invas ive ▁and ▁mig rat ory , ▁making ▁them ▁very ▁dangerous , ▁for ▁they ▁can ▁easily ▁spread ▁cancer ▁across ▁the ▁body ▁into