▁cells ▁including ▁d end rit ic ▁cells , ▁macro ph ages , ▁and ▁NK ▁cells . ▁ ▁A xl ▁is ▁an ▁in hib itor ▁of ▁the ▁inn ate ▁imm une ▁response . ▁The ▁function ▁of ▁activ ated ▁A X L ▁in ▁normal ▁t issues ▁includes ▁the ▁efficient ▁clear ance ▁of ▁apo pt otic ▁material ▁and ▁the ▁d amp ening ▁of ▁T LR - dependent ▁infl am mat ory ▁responses ▁and ▁natural ▁k iller ▁cell ▁activity . ▁ ▁A X L ▁is ▁a ▁put ative ▁driver ▁of ▁diverse ▁cell ular ▁processes ▁that ▁are ▁critical ▁for ▁the ▁development , ▁growth , ▁and ▁spread ▁of ▁tum ours , ▁including ▁pro l ifer ation , ▁invas iveness ▁and ▁migration , ▁ ▁ep ith el ial - to - mes en ch ym al ▁transition , ▁stem ness , ▁ang i ogen esis , ▁and ▁imm une ▁mod ulation . ▁A X L ▁has ▁been ▁imp licated ▁as ▁a ▁cancer ▁driver ▁and ▁correl ated ▁with ▁poor ▁surv ival ▁in ▁numerous ▁ag gress ive ▁tum ors ▁including ▁triple - negative ▁breast ▁cancer ▁( T N BC ), ▁ac ute ▁my el oid ▁le uk emia ▁( AML ), ▁non - small - cell ▁lung ▁cancer ▁( NS CLC ), ▁pan cre atic ▁cancer ▁and ▁o var ian ▁cancer , ▁among ▁others . ▁ ▁C lin ical ▁significance ▁A xl ▁was ▁first ▁isolated ▁in ▁ 1 9 8 8 ▁and ▁identified ▁as ▁an ▁on c ogene ▁in ▁a ▁screen ▁for ▁transform ing ▁gen es ▁in ▁patients ▁with ▁a ▁chron ic