▁with ▁and ▁without ▁V G CC ▁ant ib od ies , ▁have ▁detect able ▁ant ib od ies ▁against ▁the ▁M 1 ▁sub type ▁of ▁the ▁ac et yl ch oline ▁re ceptor ; ▁ ▁their ▁presence ▁may ▁particip ate ▁in ▁a ▁lack ▁of ▁compens ation ▁for ▁the ▁weak ▁calci um ▁infl ux . ▁ ▁A part ▁from ▁the ▁decre ased ▁calci um ▁infl ux , ▁ ▁a ▁dis ruption ▁of ▁active ▁zone ▁ves icle ▁release ▁sites ▁also ▁occurs , ▁which ▁may ▁also ▁be ▁ant ib ody - dependent , ▁since ▁people ▁with ▁LE MS ▁have ▁ant ib od ies ▁to ▁components ▁of ▁these ▁active ▁zones ▁( including ▁voltage - dependent ▁calci um ▁channels ). ▁T ogether , ▁these ▁ab normal ities ▁lead ▁to ▁the ▁decrease ▁in ▁mus cle ▁contract ility . ▁Re pe ated ▁stim uli ▁over ▁a ▁period ▁of ▁about ▁ 1 0 ▁seconds ▁eventually ▁lead ▁to ▁sufficient ▁delivery ▁of ▁calci um , ▁and ▁an ▁increase ▁in ▁mus cle ▁contra ction ▁to ▁normal ▁levels , ▁which ▁can ▁be ▁demonstrated ▁using ▁an ▁elect rod i agnostic ▁medicine ▁study ▁called ▁need le ▁elect rom y ography ▁by ▁increasing ▁amplitude ▁of ▁repeated ▁comp ound ▁mus cle ▁action ▁potential s . ▁ ▁The ▁ant ib od ies ▁found ▁in ▁LE MS ▁associated ▁with ▁lung ▁cancer ▁also ▁bind ▁to ▁calci um ▁channels ▁in ▁the ▁cancer ▁cells , ▁and ▁it ▁is ▁pres umed ▁that ▁the ▁ant ib od ies ▁originally ▁develop ▁as ▁a ▁reaction ▁to ▁these ▁cells . ▁It ▁has ▁been ▁suggested ▁that ▁the ▁imm une ▁reaction