iv ities . ▁ ▁Altern ative ▁sp lice ▁variants ▁of ▁GR M 8 ▁have ▁been ▁described ▁but ▁their ▁full - length ▁nature ▁has ▁not ▁been ▁determined . ▁ ▁Lig ands ▁▁▁ ▁( S )- 3 , 4 - D CP G : ▁ag on ist ▁ ▁See ▁also ▁▁ ▁Met ab otrop ic ▁gl ut am ate ▁re ceptor ▁ ▁Model ▁organ isms ▁Model ▁organ isms ▁have ▁been ▁used ▁in ▁the ▁study ▁of ▁GR M 8 ▁function . ▁A ▁conditional ▁knock out ▁mouse ▁line ▁called ▁Gr m 8 tm 2 a ( K O MP ) W t si ▁was ▁generated ▁at ▁the ▁Well come ▁Trust ▁S anger ▁Institute . ▁Male ▁and ▁female ▁animals ▁under w ent ▁a ▁standard ized ▁phen ot yp ic ▁screen ▁to ▁determine ▁the ▁effects ▁of ▁delet ion . ▁Add itional ▁screens ▁performed : ▁ ▁- ▁In - depth ▁imm un ological ▁phen ot yp ing ▁ ▁References ▁ ▁Further ▁reading ▁ ▁Category : Met ab otrop ic ▁gl ut am ate ▁re cept ors <0x0A> </s> ▁Silver ▁F ork ▁American ▁River ▁is ▁a ▁trib ut ary ▁of ▁the ▁South ▁F ork ▁American ▁River ▁in ▁the ▁Sierra ▁Nev ada ▁near ▁Lake ▁T ah oe ▁in ▁Northern ▁California . ▁▁ ▁It ▁begins ▁in ▁Am ador ▁County ▁above ▁Silver ▁Lake ▁near ▁Kit ▁Car son , ▁just ▁west ▁of ▁Kirk wood ▁Mountain ▁Res ort , ▁at ▁an ▁elev ation ▁of ▁almost ▁ 8 , 0 0 0 ▁feet . ▁After ▁exit ing ▁Silver ▁Lake ▁near ▁Car son ▁Pass ▁Highway , ▁Silver ▁F