▁position . ▁After ▁ring - open ing ▁to ▁a ▁dia zo ▁intermediate , ▁C - C ▁bond ▁rotation ▁is ▁possible ▁with ▁ 1 , 3 - m igration ▁of ▁a ▁pro ton . ▁▁ ▁C ertain ▁ 1 - alk yl - 2 - imin opy rim id ines ▁also ▁display ▁this ▁type ▁of ▁re arr ang ement . ▁ ▁In ▁the ▁first ▁step ▁is ▁an ▁addition ▁reaction ▁of ▁water ▁followed ▁by ▁ring - open ing ▁of ▁the ▁hem iam inal ▁to ▁the ▁am ino al de hy de ▁followed ▁by ▁ring ▁closure . ▁ ▁References ▁ ▁Category : R ear r ang ement ▁re actions ▁Category : Name ▁re actions <0x0A> </s> ▁is ▁a ▁district ▁located ▁in ▁W ak ay ama ▁Pref ect ure , ▁Japan . ▁ ▁As ▁of ▁September ▁ 1 , ▁ 2 0 0 8 , ▁the ▁district ▁has ▁an ▁estimated ▁population ▁of ▁ 2 8 , 1 7 1 ▁and ▁a ▁density ▁of ▁ 8 4 . 6 ▁persons / km ². ▁The ▁total ▁area ▁is ▁ 3 3 2 . 9 3   km ². ▁ ▁Town s ▁and ▁villages ▁▁ ▁K ats ur agi ▁ ▁K ō ya ▁ ▁K udo y ama ▁ ▁Tim eline ▁▁ ▁On ▁October ▁ 1 , ▁ 2 0 0 5 ▁the ▁village ▁of ▁Han az ono ▁merged ▁into ▁the ▁town ▁of ▁K ats ur agi . ▁( 4 ▁towns ) ▁ ▁On ▁March ▁ 1 , ▁ 2 0 0 6 ▁the ▁town ▁of ▁K ō y ag