ated ▁protein ▁complex es ▁are ▁believed ▁to ▁interact ▁with ▁the ▁cy top las mic ▁t ails ▁of ▁memb rane ▁prote ins , ▁leading ▁to ▁their ▁selection ▁and ▁concentration . ▁Therefore , ▁adapt or ▁prote ins ▁are ▁responsible ▁for ▁the ▁rec ruit ment ▁of ▁cargo ▁mole cules ▁into ▁a ▁growing ▁cl ath rin - co ated ▁p its . ▁The ▁two ▁major ▁types ▁of ▁cl ath rin ▁adapt or ▁complex es ▁are ▁the ▁heter ot et ram er ic ▁ves icular ▁transport ▁adapt or ▁prote ins ▁( AP 1 - 5 ), ▁and ▁the ▁mon omer ic ▁G GA ▁( G ol gi - local ising , ▁G amma - ada pt in ▁ear ▁hom ology , ▁AR F - binding ▁prote ins ) ▁adapt ors . ▁Ada pt ins ▁are ▁dist antly ▁related ▁to ▁the ▁other ▁main ▁type ▁of ▁ves icular ▁transport ▁prote ins , ▁the ▁co atom er ▁sub un its , ▁sharing ▁between ▁ 1 6 % ▁and ▁ 2 6 % ▁of ▁their ▁am ino ▁acid ▁sequence . ▁ ▁Ada pt or ▁protein ▁( AP ) ▁complex es ▁are ▁found ▁in ▁co ated ▁ves icles ▁and ▁cl ath rin - co ated ▁p its . ▁AP ▁complex es ▁connect ▁cargo ▁prote ins ▁and ▁lip ids ▁to ▁cl ath rin ▁at ▁ves icle ▁bud ding ▁sites , ▁as ▁well ▁as ▁binding ▁access ory ▁prote ins ▁that ▁reg ulate ▁coat ▁assembly ▁and ▁dis assembly ▁( such ▁as ▁AP 1 8 0 , ▁e ps ins ▁and ▁aux il in ). ▁There ▁are