- len al id om ide - dex am eth as one ▁( IR d ) ▁compared ▁with ▁place bo . ▁High - ris k ▁c yt ogen etic ▁ab normal ities ▁were ▁defined ▁as ▁del ( 1 7 p ), ▁t ( 4 ; 1 4 ), ▁and / or ▁t ( 1 4 ; 1 6 ); ▁addition ally , ▁patients ▁were ▁ass essed ▁for ▁ 1 q 2 1 ▁ampl ification . ▁Of ▁ 7 2 2 ▁random ized ▁patients , ▁ 5 5 2 ▁had ▁c yt ogen etic ▁results ; ▁ 1 3 7 ▁( 2 5 %) ▁had ▁high - ris k ▁c yt ogen etic ▁ab normal ities ▁and ▁ 1 7 2 ▁( 3 2 %) ▁had ▁ 1 q 2 1 ▁ampl ification ▁alone . ▁P FS ▁was ▁improved ▁with ▁IR d ▁versus ▁place bo ▁in ▁both ▁high - ris k ▁and ▁standard - ris k ▁c yt ogen et ics ▁sub groups : ▁in ▁high - ris k ▁patients , ▁with ▁median ▁P FS ▁of ▁ 2 1 . 4 ▁versus ▁ 9 . 7 ▁months ; ▁in ▁standard - ris k ▁patients , ▁with ▁median ▁P FS ▁of ▁ 2 0 . 6 ▁versus ▁ 1 5 . 6 ▁months . ▁This ▁P FS ▁benefit ▁was ▁consistent ▁across ▁sub groups ▁with ▁individual ▁high - ris k ▁c yt ogen etic ▁ab normal ities , ▁including ▁patients ▁with ▁del ( 1 7 p ). ▁P FS ▁was ▁also ▁longer ▁with ▁IR d ▁versus