h ydro x yst ero id ▁de h ydro gen ase , ▁ 2 1 - h ydro x yl ase , ▁and ▁ 1 1 β - h ydro x yl ase . ▁It ▁has ▁also ▁been ▁found ▁to ▁be ▁a ▁weak ▁in hib itor ▁of ▁ster oid ▁sul f at ase ▁( K i ▁= ▁ 2 . 3 – 8 . 2   μ M ), ▁the ▁en zym e ▁that ▁converts ▁ ▁into ▁ ▁and ▁est r one ▁sul f ate ▁into ▁est r one ▁( which ▁can ▁then ▁respectively ▁be ▁transformed ▁into ▁est r one ▁( with ▁and ro sten ed ione ▁as ▁an ▁intermediate ) ▁and ▁est rad i ol ), ▁though ▁another ▁study ▁reported ▁its ▁in hib ition ▁to ▁be ▁pot ent ▁and ▁potentially ▁clin ically ▁relevant . ▁Although ▁in ▁contradiction ▁with ▁the ▁above ▁data , ▁another ▁study ▁found ▁that ▁dan az ol ▁weak ly ▁in hib ited ▁a rom at ase ▁as ▁well , ▁with ▁ 4 4 % ▁in hib ition ▁at ▁a ▁concentration ▁of ▁ 1 0   μ M . ▁ ▁In ▁accord ance ▁with ▁its ▁ster oid ogen esis ▁in hib ition , ▁clin ical ▁studies ▁have ▁demonstrated ▁that ▁dan az ol ▁directly ▁and ▁marked ly ▁in hib its ▁ad ren al , ▁o var ian , ▁and ▁test icular ▁ster oid ogen esis ▁in ▁v ivo . ▁The ▁en zym atic ▁production ▁of ▁est rad i ol , ▁pro g ester one , ▁and ▁test oster one ▁have ▁all ▁specifically