▁by ▁reve aling ▁crypt ic ▁binding ▁sites ▁in ▁EC M ▁mole cules . ▁For ▁instance , ▁M MP - 2 ▁de grad ation ▁of ▁col lagen ▁type ▁I ▁can ▁reve al ▁a ▁previously ▁in access ible ▁crypt ic ▁binding ▁site ▁that ▁bind s ▁with ▁the ▁α v β 3 ▁integr in ▁expressed ▁by ▁human ▁mel an oma ▁cells . ▁Sign aling ▁through ▁this ▁integr in ▁is ▁necessary ▁for ▁mel an oma ▁cell ▁vi ability ▁and ▁growth ▁in ▁a ▁col lagen ▁matrix ▁and ▁can ▁potentially ▁rescue ▁the ▁cells ▁from ▁apo pt osis . ▁As ▁another ▁example , ▁cle av age ▁of ▁l amin in - 5 , ▁a ▁component ▁of ▁the ▁bas ement ▁memb rane , ▁by ▁M MP - 2 ▁has ▁been ▁shown ▁to ▁reve al ▁a ▁crypt ic ▁site ▁indu cing ▁migration ▁of ▁breast ▁ep ith el ial ▁cells . ▁ ▁More ▁generally , ▁by ▁de grad ing ▁the ▁EC M , ▁M MP s ▁release ▁growth ▁factors ▁that ▁were ▁previously ▁bound ▁to ▁the ▁EC M , ▁allowing ▁them ▁to ▁bind ▁with ▁cell ▁re cept ors ▁and ▁influence ▁cell ▁signal ing . ▁Furthermore , ▁many ▁M MP s ▁also ▁activ ate ▁other ▁pro M MP s ▁along ▁with ▁growth ▁factors . ▁M MP - 2 ▁has ▁also ▁been ▁shown ▁to ▁cle ave ▁other ▁non - EC M ▁substr ates ▁including ▁growth ▁factors ▁such ▁as ▁T G F - β , ▁F G F ▁re ceptor - 1 , ▁pro T NF , ▁IL - 1 β ▁and ▁various ▁chem ok ines .