1 2 9 ▁ng / ml ▁vs . ▁ 1 4 . 1   ng / ml ). ▁ ▁Met abol ism ▁ ▁Medical ▁uses ▁ ▁Major ▁de press ive ▁dis order ▁▁ ▁Pre lim inary ▁research ▁suggests ▁that ▁lev ome fol ic ▁acid ▁( L - m eth yl fol ate ) ▁taken ▁with ▁a ▁first - line ▁ant ide press ant ▁may ▁provide ▁an ▁adj unct ive ▁ant ide press ant ▁effect ▁for ▁individuals ▁who ▁do ▁not ▁respond ▁or ▁have ▁only ▁a ▁partial ▁th era pe ut ic ▁response ▁to ▁SS RI ▁or ▁SN RI ▁medic ation , ▁and ▁might ▁be ▁a ▁more ▁cost - effect ive ▁adj unct ive ▁agent ▁than ▁second - gener ation ▁anti ps ych ot ics . ▁ ▁Card i ov asc ular ▁disease ▁and ▁cancer ▁▁ ▁Lev ome fol ic ▁acid ▁( and ▁fol ic ▁acid ▁in ▁turn ) ▁has ▁been ▁proposed ▁for ▁treatment ▁of ▁card i ov asc ular ▁disease ▁and ▁advanced ▁can cers ▁such ▁as ▁breast ▁and ▁col ore ct al ▁can cers . ▁It ▁by pass es ▁several ▁met abol ic ▁steps ▁in ▁the ▁body ▁and ▁better ▁bind s ▁th ym id yl ate ▁synth ase ▁with ▁F d U MP , ▁a ▁met abol ite ▁of ▁the ▁drug ▁flu or ou rac il . ▁ ▁Pat ent ▁issues ▁In ▁March ▁ 2 0 1 2 , ▁Mer ck ▁& ▁C ie ▁of ▁Switzerland , ▁Pam lab ▁L LC ▁( maker ▁of ▁Met an x ▁and ▁C ere fol in , ▁Ne