▁This ▁mechanism ▁can ▁also ▁affect ▁m amm al ian ▁cell ▁rep lication . ▁In ▁particular , ▁some ▁con gen ers ▁of ▁this ▁drug ▁family ▁( for ▁example ▁those ▁that ▁contain ▁the ▁C - 8 ▁flu or ine ), ▁display ▁high ▁activity ▁not ▁only ▁against ▁b acter ial ▁to pois omer ases , ▁but ▁also ▁against ▁e uk ary otic ▁to pois omer ases ▁and ▁are ▁to xic ▁to ▁cult ured ▁m amm al ian ▁cells ▁and ▁in ▁v ivo ▁tum or ▁models . ▁ ▁Although ▁qu in ol ones ▁are ▁highly ▁to xic ▁to ▁m amm al ian ▁cells ▁in ▁culture , ▁its ▁mechanism ▁of ▁c yt ot ox ic ▁action ▁is ▁not ▁known . ▁Qu in ol one ▁induced ▁DNA ▁damage ▁was ▁first ▁reported ▁in ▁ 1 9 8 6 ▁( H uss y ▁et ▁al .). ▁ ▁Rec ent ▁studies ▁have ▁demonstrated ▁a ▁correlation ▁between ▁m amm al ian ▁cell ▁c yt ot ox icity ▁of ▁the ▁qu in ol ones ▁and ▁the ▁induction ▁of ▁mic ron uc lei . ▁ ▁As ▁such , ▁some ▁flu oro quin ol ones ▁may ▁cause ▁injury ▁to ▁the ▁chrom os ome ▁of ▁e uk ary otic ▁cells . ▁ ▁There ▁continues ▁to ▁be ▁considerable ▁debate ▁as ▁to ▁whether ▁or ▁not ▁this ▁DNA ▁damage ▁is ▁to ▁be ▁considered ▁one ▁of ▁the ▁mechan isms ▁of ▁action ▁concerning ▁the ▁severe ▁ad verse ▁re actions ▁experienced ▁by ▁some ▁patients ▁following ▁flu oro quin ol one ▁ther apy . ▁ ▁Ad verse ▁re actions ▁Fl um equ ine ▁was