- century ▁Dutch ▁pain ters ▁Category : D utch ▁male ▁pain ters ▁Category : 2 0 th - century ▁Dutch ▁pain ters ▁Category : An imal ▁artists ▁Category : Pe ople ▁from ▁G ron ingen ▁( city ) ▁Category : Ro yal ▁Academy ▁of ▁Fine ▁Arts ▁( Ant werp ) ▁al umn i <0x0A> </s> ▁Bal an ol ▁is ▁a ▁fung al ▁met abol ite ▁produced ▁by ▁the ▁fung us ▁Vert ic ill ium ▁bal ano ides . ▁It ▁is ▁a ▁pot ent ▁in hib itor ▁of ▁the ▁ser ine / th re on ine ▁kin ases ▁protein ▁kin ase ▁A ▁( PK A ) ▁and ▁protein ▁kin ase ▁C ▁( PK C ), ▁binding ▁in ▁a ▁similar ▁manner ▁with ▁that ▁of ▁ATP . ▁Bal an ol ▁was ▁discovered ▁in ▁ 1 9 9 3 ▁in ▁the ▁search ▁for ▁novel ▁in hib itors ▁of ▁PK C , ▁a ▁member ▁of ▁a ▁family ▁of ▁ser ine / th re on ine ▁kin ases ▁whose ▁over activ ation ▁is ▁associated ▁with ▁numerous ▁human ▁dise ases ▁of ▁signal ▁trans du ction ▁including ▁cancer . ▁However , ▁much ▁of ▁the ▁research ▁on ▁bal an ol ▁focus es ▁on ▁how ▁chemical ▁modifications ▁of ▁the ▁mole cular ▁structure ▁affect ▁binding ▁to ▁PK A . ▁Indeed , ▁bal an ol , ▁its ▁chem ically ▁alter ed ▁anal ogs , ▁and ▁their ▁interactions ▁with ▁PK A ▁in ▁particular ▁are ▁used ▁to ▁ill uminate ▁the ▁roles ▁of ▁select ivity ▁and ▁protein ▁flex ibility ▁in ▁the ▁in hib ition ▁of ▁kin ases .