in ▁from ▁the ▁inter cal ated ▁disc / s ar co lemma ▁to ▁the ▁nucle us , ▁ev iden ced ▁by ▁a ▁reduction ▁of ▁beta - c aten in ▁expression ▁in ▁the ▁memb rane ▁protein ▁fraction ▁and ▁an ▁increase ▁in ▁the ▁nuclear ▁fraction . ▁Additionally , ▁they ▁found ▁a ▁weak ening ▁in ▁the ▁association ▁between ▁g ly c ogen ▁synth ase ▁kin ase - 3 β ▁and ▁beta - c aten in , ▁which ▁may ▁indicate ▁alter ed ▁protein ▁stability . ▁Over all , ▁results ▁suggest ▁that ▁an ▁en hanced ▁nuclear ▁local ization ▁of ▁beta - c aten in ▁may ▁be ▁important ▁in ▁the ▁pro gression ▁of ▁card iac ▁hy pert ro phy . ▁ ▁Regarding ▁the ▁mechan istic ▁role ▁of ▁beta - c aten in ▁in ▁card iac ▁hy pert ro phy , ▁trans gen ic ▁mouse ▁studies ▁have ▁shown ▁somewhat ▁conflic ting ▁results ▁regarding ▁whether ▁up reg ulation ▁of ▁beta - c aten in ▁is ▁benef icial ▁or ▁det r iment al . ▁A ▁recent ▁study ▁using ▁a ▁conditional ▁knock out ▁mouse ▁that ▁either ▁lack ed ▁beta - c aten in ▁altogether ▁or ▁expressed ▁a ▁non - de grad able ▁form ▁of ▁beta - c aten in ▁in ▁card iom y ocy tes ▁recon ci led ▁a ▁potential ▁reason ▁for ▁these ▁dis cre pan cies . ▁There ▁appears ▁to ▁be ▁strict ▁control ▁over ▁the ▁sub cell ular ▁local ization ▁of ▁beta - c aten in ▁in ▁card iac ▁mus cle . ▁M ice ▁lack ing ▁beta - c aten in ▁had