▁production . ▁David ▁Scott , ▁whom ▁Fitz G er ald ▁had ▁personally ▁rec ru ited ▁for ▁the ▁task , ▁successfully ▁replaced ▁Col lip ' s ▁alco hol - based ▁method ▁with ▁ac et one ▁use ▁to ▁allow ▁for ▁consistent ▁results ▁during ▁the ▁three ▁months ▁prior ▁to ▁external ▁collaboration . ▁Peter ▁J . ▁Mol oney ▁pione ered ▁an ▁ad s or ption ▁method ▁using ▁ben zo ic ▁acid ▁that ▁reduced ▁the ▁amount ▁of ▁necessary ▁alco hol / ac et one ▁to ▁a ▁minimal ▁do se ▁and ▁elimin ated ▁far ▁more ▁protein ▁material ▁than ▁had ▁been ▁previously ▁possible . ▁Some ▁ 2 5 0 , 0 0 0 ▁units ▁of ▁ins ul in ▁using ▁the ▁combination ▁of ▁these ▁methods ▁were ▁produced ▁at ▁Con n aught ▁for ▁clin ical ▁use ▁in ▁Toronto ▁during ▁the ▁fall ▁of ▁ 1 9 2 2 , ▁with ▁" very ▁satisf actory ▁results ," ▁according ▁to ▁Best ▁and ▁Scott . ▁By ▁early ▁November , ▁Con n aught ▁was ▁producing ▁about ▁ 1 ▁lit re ▁of ▁ins ul in ▁per ▁week . ▁ ▁Non eth eless , ▁large - scale ▁manufact ure ▁of ▁ins ul in ▁at ▁Con n aught ▁reached ▁its ▁limits , ▁prompt ing ▁the ▁research ers ▁to ▁contract ▁with ▁Eli ▁L illy ▁and ▁Company ▁to ▁increase ▁production ▁and ▁accept ▁pat ents ▁in ▁Canada , ▁the ▁United ▁States , ▁and ▁Great ▁Britain . ▁B ant ing ▁object ed ▁initially ▁to ▁the ▁taking ▁out ▁of ▁pat ents ▁and ▁the ▁charg ing ▁of ▁roy alt ies ▁for ▁the ▁manufact ure ▁of ▁ins