▁for wards ▁Category : E HC ▁München ▁players ▁Category : E is b ären ▁Berlin ▁players ▁Category : H ern ing ▁Blue ▁Fox ▁players ▁Category : I ser lo hn ▁Ro ost ers ▁players ▁Category : L iving ▁people ▁Category : Pe ople ▁from ▁Hern ing ▁Municip ality ▁Category : S ø nder j y sk E ▁I sh ockey ▁players <0x0A> </s> ▁St rom al ▁interaction ▁mole c ule ▁ 1 ▁is ▁a ▁protein ▁that ▁in ▁humans ▁is ▁encoded ▁by ▁the ▁ST IM 1 ▁gene . ▁ST IM 1 ▁has ▁a ▁single ▁transm emb rane ▁domain , ▁and ▁is ▁local ized ▁to ▁the ▁end op las mic ▁ret icul um , ▁and ▁to ▁a ▁less er ▁extent ▁to ▁the ▁pl asma ▁memb rane . ▁ ▁Even ▁though ▁the ▁protein ▁has ▁been ▁identified ▁earlier , ▁its ▁function ▁was ▁unknown ▁until ▁recently . ▁In ▁ 2 0 0 5 , ▁it ▁was ▁discovered ▁that ▁ST IM 1 ▁functions ▁as ▁a ▁calci um ▁sensor ▁in ▁the ▁end op las mic ▁ret icul um . ▁Upon ▁activation ▁of ▁the ▁IP 3 ▁re ceptor , ▁the ▁calci um ▁concentration ▁in ▁the ▁end op las mic ▁ret icul um ▁decre ases , ▁which ▁is ▁sens ed ▁by ▁ST IM 1 , ▁via ▁its ▁EF ▁hand ▁domain . ▁ST IM 1 ▁activ ates ▁the ▁" store - oper ated " ▁O RA I 1 ▁calci um ▁ion ▁channels ▁in ▁the ▁pl asma ▁memb rane , ▁via ▁int rac ell ular ▁ST IM 1 ▁movement , ▁clust ering ▁under ▁pl