. ▁This ▁indicates ▁that ▁ben zo [ c ] flu or ene ▁is ▁met abol ized ▁by ▁en zym es ▁in ▁the ▁rat ▁li ver ▁into ▁more ▁pot ent ▁mut agen ic ▁comp ounds . ▁These ▁comp ounds ▁only ▁affected ▁the ▁T A 9 8 ▁stra in . ▁This ▁indicates ▁that ▁the ▁ad duct s ▁formed ▁by ▁ben zo [ c ] flu or ene ▁met abol ites ▁cause ▁frames h ift ▁mut ations , ▁and ▁not ▁point ▁mut ations . ▁ ▁Effect s ▁on ▁animals ▁In ▁one ▁animal ▁study , ▁m ice ▁that ▁were ▁fed ▁coal ▁tar ▁developed ▁lung ▁tum ors . ▁DNA ▁ad duct s ▁in ▁these ▁m ice ▁were ▁analyz ed ▁and ▁could ▁be ▁trac ed ▁back ▁to ▁ben zo [ c ] flu or ene . ▁This ▁and ▁another ▁similar ▁study ▁suggest ▁a ▁contribution ▁of ▁ben zo [ c ] flu or ene ▁to ▁the ▁car cin ogen ic ▁pot ency ▁of ▁coal ▁tar ▁when ▁admin ister ed ▁or ally . ▁ ▁Another ▁study ▁found ▁that ▁ben zo [ c ] flu or ene ▁is ▁also ▁car cin ogen ic ▁in ▁m ice ▁when ▁applied ▁top ically , ▁indu cing ▁lung ▁and ▁skin ▁cancer . ▁Of ▁the ▁results ▁of ▁this ▁study ▁a ▁do se - response ▁curve ▁has ▁been ▁made , ▁see ▁the ▁image ▁above . ▁▁ ▁This ▁figure ▁shows ▁the ▁DNA ▁ad duct ▁level ▁after ▁a ▁certain ▁do se ▁of ▁ben zo [ c ] flu or ene ▁was ▁applied ▁to ▁the ▁skin ▁of ▁m ice . ▁This