3 , 4 - d ih yd rod i ol ▁( 2 ). ▁This ▁subst ance ▁is ▁transformed ▁by ▁C Y P 1 A 1 ▁into ▁the ▁highly ▁car cin ogen ic ▁met abol ites ▁anti - d io le po x ide ▁( 3 ) ▁and ▁syn - d io le po x ide ▁( 4 ). ▁ ▁AD ME ▁of ▁ben zo [ c ] flu or ene ▁and ▁PA H s ▁in ▁general ▁ ▁Abs or ption ▁Ben zo [ c ] flu or ene ▁and ▁PA H s ▁in ▁general ▁are ▁mostly ▁absor bed ▁via ▁ing estion , ▁in hal ation , ▁and ▁der mal ▁contact . ▁Also , ▁depending ▁on ▁the ▁vehicle ▁( transport ▁medium ) ▁in ▁which ▁the ▁PA H s ▁are ▁located , ▁the ▁percent ages ▁of ▁absor ption ▁can ▁differ . ▁Ing estion ▁of ▁ben zo [ c ] flu or ene ▁makes ▁it ▁a ▁very ▁pot ent ▁lung ▁tum or igen ▁ ▁In ▁particular , ▁ben zo [ c ] flu or ene ▁is ▁better ▁absor bed ▁in ▁the ▁l ungs . ▁ ▁Distribution ▁Once ▁it ▁is ▁absor bed , ▁ben zo [ c ] flu or ene ▁enters ▁the ▁l ym ph , ▁circul ates ▁in ▁the ▁blood ▁and ▁is ▁met abol ized . ▁The ▁distribution ▁of ▁PA H s ▁depends ▁on ▁their ▁lip oph il icity ▁and ▁probably ▁ben zo [ c ] flu or ene ▁can ▁easily ▁cross ▁the ▁cell ▁memb rane , ▁because ▁of ▁this ▁lip oph il icity .