▁array ▁could ▁become ▁c log ged ▁by ▁excess ive ▁sw elling ▁or ▁fla wed ▁design . ▁This ▁design ▁also ▁increases ▁the ▁lik elihood ▁of ▁bu ck ling ▁under ▁the ▁pressure ▁of ▁, ▁and ▁therefore ▁failing ▁to ▁deliver ▁any ▁dru gs . ▁ ▁Co ated ▁ ▁Just ▁like ▁solid ▁mic r one ed les , ▁co ated ▁mic r one ed les ▁are ▁usually ▁designed ▁from ▁polym ers ▁or ▁met als . ▁In ▁this ▁method ▁the ▁drug ▁is ▁applied ▁directly ▁to ▁the ▁mic r one ed le ▁array ▁instead ▁of ▁being ▁applied ▁through ▁other ▁patch es ▁or ▁applic ators . ▁Co ated ▁mic r one ed les ▁are ▁often ▁covered ▁in ▁other ▁sur fact ants ▁or ▁thick ening ▁agents ▁to ▁ass ure ▁that ▁the ▁drug ▁is ▁delivered ▁properly . ▁Some ▁of ▁the ▁chemical s ▁used ▁on ▁co ated ▁mic r one ed les ▁are ▁known ▁ir rit ants . ▁While ▁there ▁is ▁risk ▁of ▁local ▁infl amm ation ▁to ▁the ▁area ▁where ▁the ▁array ▁was , ▁the ▁array ▁can ▁be ▁removed ▁immediately ▁with ▁no ▁harm ▁to ▁the ▁patient . ▁ ▁D iss ol v able ▁ ▁In ▁a ▁more ▁recent ▁adaptation ▁of ▁the ▁mic r one ed le ▁design , ▁dissol v able ▁mic r one ed les ▁enc aps ulate ▁the ▁drug ▁in ▁a ▁non to xic ▁polym er ▁which ▁dissol ves ▁once ▁inside ▁the ▁skin . ▁This ▁polym er ▁would ▁allow ▁the ▁drug ▁to ▁be ▁delivered ▁into ▁the ▁skin ▁and ▁could ▁be ▁broken ▁down ▁once ▁inside ▁the ▁body . ▁Ph arma ce