▁Auto imm une ▁dise ases ▁ ▁R he um ato id ▁ar th rit is ▁ ▁An k yl osing ▁sp ond yl itis ▁ ▁Cro hn ▁disease ▁and ▁ul cer ative ▁col itis ▁ ▁Chron ic ▁in fe ctions ▁ ▁T uber cul osis ▁ ▁Bron ch ie ct asis ▁ ▁Chron ic ▁o ste omy el itis ▁ ▁Auto infl am mat ory ▁dise ases ▁ ▁Famil ial ▁Mediter rane an ▁fe ver ▁( FM F ) ▁▁ ▁M uck le – W ells ▁synd rome ▁( M WS ) ▁ ▁Can cer ▁ ▁H od g kin ' s ▁l ym ph oma ▁ ▁Ren al ▁cell ▁car cin oma ▁ ▁Chron ic ▁foreign ▁body ▁reaction ▁ ▁H IV / A ID S ▁ ▁Sil ic one - indu ced ▁gran ul om at ous ▁reaction ▁ ▁Path ology ▁ ▁In ▁a ▁health y ▁individual , ▁the ▁median ▁pl asma ▁concentration ▁of ▁S AA ▁is ▁ 3   m g ▁per ▁liter . ▁This ▁can ▁increase ▁to ▁over ▁ 2 0 0 0   m g ▁per ▁liter ▁during ▁an ▁ac ute ▁phase ▁response ▁and ▁a ▁sust ained ▁over production ▁of ▁S AA ▁is ▁required ▁for ▁the ▁creation ▁of ▁the ▁AA ▁depos its ▁that ▁define ▁AA ▁am y lo idos is . ▁ ▁High ▁levels ▁of ▁S AA , ▁however , ▁is ▁not ▁a ▁sufficient ▁condition ▁for ▁the ▁development ▁of ▁system ic ▁AA ▁am y lo idos is ▁and ▁it ▁remains ▁unclear ▁what ▁triggers ▁the ▁accum ulation ▁of ▁AA .