▁improve ▁the ▁mu co ad hes ive ▁bond . ▁ ▁De h yd r ation ▁theory ▁▁ ▁The ▁de h yd r ation ▁theory ▁explains ▁why ▁mu co ad hes ion ▁can ▁arise ▁rapidly . ▁When ▁two ▁g els ▁capable ▁of ▁rapid ▁gel ation ▁in ▁an ▁a que ous ▁environment ▁are ▁brought ▁into ▁contact , ▁movement ▁occurs ▁between ▁the ▁two ▁g els ▁until ▁a ▁state ▁of ▁equilibrium ▁is ▁reached . ▁G els ▁associated ▁with ▁a ▁strong ▁aff inity ▁for ▁water ▁will ▁have ▁high ▁os m otic ▁press ures ▁and ▁large ▁sw elling ▁forces . ▁The ▁difference ▁in ▁os m otic ▁pressure ▁when ▁these ▁g els ▁contact ▁m uc us ▁g els ▁will ▁draw ▁water ▁into ▁the ▁form ulation ▁and ▁quickly ▁de h yd rate ▁the ▁m uc us ▁gel , ▁forcing ▁inter mix ing ▁and ▁cons olid ation ▁until ▁equilibrium ▁results . ▁ ▁This ▁mixture ▁of ▁form ulation ▁and ▁m uc us ▁can ▁increase ▁contact ▁time ▁with ▁the ▁m uc ous ▁memb rane , ▁leading ▁to ▁the ▁cons olid ation ▁of ▁the ▁ad hes ive ▁bond . ▁However , ▁the ▁de h yd r ation ▁theory ▁does ▁not ▁apply ▁to ▁solid ▁form ulations ▁or ▁highly ▁hyd r ated ▁forms . ▁ ▁Mu co ad hes ives ▁in ▁drug ▁delivery ▁ ▁Depending ▁on ▁the ▁dos age ▁form ▁and ▁route ▁of ▁administration , ▁mu co ad hes ives ▁may ▁be ▁used ▁for ▁either ▁local ▁or ▁system ic ▁drug ▁delivery . ▁An ▁over view ▁on ▁the ▁mu co ad hes ive ▁properties ▁of ▁mu co ad