- wide ▁association ▁studies . ▁The ▁P HA CT R 1 ▁gene ▁also ▁contains ▁one ▁of ▁ 2 7 ▁SN P s ▁associated ▁with ▁increased ▁risk ▁of ▁coron ary ▁ar tery ▁disease . ▁ ▁Str ucture ▁ ▁Gene ▁ ▁The ▁P HA CT R 1 ▁gene ▁res ides ▁on ▁chrom os ome ▁ 6 ▁at ▁the ▁band ▁ 6 p 2 4 . 1 ▁and ▁includes ▁ 1 9 ▁ex ons . ▁This ▁gene ▁produces ▁ 2 ▁is o forms ▁through ▁alternative ▁sp lic ing . ▁ ▁Prote in ▁ ▁P HA CT R 1 ▁is ▁a ▁member ▁of ▁the ▁ph osph at ase ▁and ▁act in ▁reg ulator ▁family ▁and ▁contains ▁ 4 ▁R PE L ▁repe ats , ▁three ▁of ▁which ▁res ide ▁at ▁the ▁C - term inal ▁and ▁bind ▁three ▁act in ▁mon om ers . ▁P HA CT R 1 ▁bind s ▁act in ▁and ▁P P 1 ▁in ▁the ▁region ▁containing ▁these ▁R PE L ▁repe ats . ▁As ▁a ▁P HA CT R ▁protein , ▁P HA CT R 1 ▁diff ers ▁from ▁other ▁P P 1 - binding ▁prote ins ▁in ▁that ▁it ▁is ▁missing ▁the ▁R / K - R / K - h ydro ph ob ic - X - F / W ▁cons ensus ▁sequence , ▁indicating ▁that ▁it ▁bind s ▁P P 1 ▁at ▁a ▁different ▁site . ▁P HA CT R 1 ▁is ▁also ▁predicted ▁to ▁contain ▁ 8 ▁PK A ▁ph osph ory lation ▁sites ▁and ▁ 7 ▁PK