): ▁M SO ▁is ▁an ▁in hib itor ▁that ▁bind s ▁to ▁the ▁gl ut am ate ▁site . ▁B ound ▁to ▁G S , ▁M SO ▁is ▁ph osph ory l ated ▁by ▁ATP ▁that ▁results ▁in ▁an ▁irre vers ible , ▁non - c oval ent ▁in hib ition ▁of ▁G S . ▁The ▁S - is omer ▁configuration ▁is ▁more ▁in hib itory . ▁Gl ut am ate ▁entry ▁is ▁blocked ▁into ▁the ▁active ▁site ▁by ▁a ▁stabil ization ▁of ▁the ▁flexible ▁loop ▁in ▁the ▁active ▁site ▁by ▁M SO . ▁ ▁Ph osph in oth ric in ( P PT , ▁Gl uf os inate ): ▁Ph osph in oth ric in ▁is ▁an ▁in hib itor ▁that ▁bind s ▁to ▁the ▁gl ut am ate ▁site . ▁Gl uf os inate ▁is ▁used ▁as ▁an ▁her b ic ide . ▁Gl uf os inate ▁treated ▁plants ▁die ▁due ▁to ▁a ▁bu il dup ▁of ▁am mon ia ▁and ▁a ▁c ess ation ▁of ▁photos yn thesis . ▁ ▁Many ▁synth etic ▁in hib itors ▁are ▁available ▁today . ▁Research ▁on ▁E . ▁col i ▁revealed ▁that ▁G S ▁is ▁reg ulated ▁through ▁gene ▁expression . ▁The ▁gene ▁that ▁enc odes ▁the ▁G S ▁sub unit ▁is ▁designated ▁g ln A . ▁Trans cription ▁of ▁g ln A ▁is ▁dependent ▁on ▁N RI ▁( a ▁specific ▁trans cription al ▁en han cer ). ▁Active ▁trans cription ▁occurs ▁if ▁N RI ▁is ▁in ▁its ▁ph osph ory l ated ▁form