▁these ▁poly ps ▁are ▁ben ign ▁in ▁nature , ▁but ▁they ▁have ▁the ▁potential ▁to ▁transform ▁into ▁dead ly ▁cancer ▁as ▁time ▁progress es . ▁Som atic ▁mut ations ▁of ▁A PC ▁in ▁col ore ct al ▁cancer ▁are ▁also ▁not ▁un common . ▁ ▁B eta - c aten in ▁and ▁A PC ▁are ▁among ▁the ▁key ▁gen es ▁( t ogether ▁with ▁others , ▁like ▁K - R as ▁and ▁S MA D 4 ) ▁involved ▁in ▁col ore ct al ▁cancer ▁development . ▁The ▁potential ▁of ▁ β - c aten in ▁to ▁change ▁the ▁previously ▁ep ith el ial ▁phen ot ype ▁of ▁affected ▁cells ▁into ▁an ▁invas ive , ▁mes en ch yme - like ▁type ▁cont ributes ▁greatly ▁to ▁met ast asis ▁formation . ▁ ▁As ▁a ▁th era pe ut ic ▁target ▁▁ ▁Due ▁to ▁its ▁invol vement ▁in ▁cancer ▁development , ▁in hib ition ▁of ▁beta - c aten in ▁continues ▁to ▁receive ▁significant ▁attention . ▁But ▁the ▁target ing ▁of ▁the ▁binding ▁site ▁on ▁its ▁arm ad illo ▁domain ▁is ▁not ▁the ▁simplest ▁task , ▁due ▁to ▁its ▁extensive ▁and ▁relatively ▁flat ▁surface . ▁However , ▁for ▁an ▁efficient ▁in hib ition , ▁binding ▁to ▁smaller ▁" hot sp ots " ▁of ▁this ▁surface ▁is ▁sufficient . ▁This ▁way , ▁a ▁" st ap led " ▁hel ical ▁pe pt ide ▁derived ▁from ▁the ▁natural ▁ β - c aten in ▁binding ▁mot if ▁found ▁in ▁LE F 1 ▁was ▁sufficient ▁for ▁the ▁complete