▁an ▁emb ry onic ▁le th al ▁phen ot ype ▁and ▁dies ▁mid ▁gest ation ▁from ▁a ▁condition ▁known ▁as ▁hydro ps ▁fet alis . ▁ ▁The ▁C AL C RL ▁or ▁CL R ▁K O ▁mouse ▁rec ap itul ates ▁the ▁same ▁phen ot ype , ▁as ▁it ▁la cks ▁both ▁the ▁AM 1 ▁and ▁AM 2 ▁re cept ors ▁( inc ident ally ▁confirm ing ▁the ▁lack ▁of ▁phys i ological ▁significance ▁for ▁the ▁earlier ▁single ▁protein ▁AM ▁re ceptor ▁discovered ▁by ▁Kap as ). ▁ ▁RA MP 2 ▁K O ▁m ice ▁also ▁rec ap itul ates ▁the ▁same ▁phen ot ype ▁showing ▁that ▁major ▁phys i ological ▁effects ▁of ▁AM ▁are ▁trans du ced ▁by ▁the ▁AM 1 ▁re ceptor . ▁ ▁Even ▁the ▁heter o zy g ote ▁RA MP ▁ 2 ▁m ice ▁have ▁dist urbed ▁phys i ology ▁with ▁unusual ▁b one ▁and ▁m amm ary ▁g land ▁defect s , ▁and ▁very ▁aber rant ▁end ocr in ology , ▁leading ▁to ▁poor ▁fert ility ▁and ▁la ct ation ▁problems . ▁ ▁What ▁is ▁very ▁surprising ▁is ▁that ▁the ▁effect ▁of ▁delet ion ▁of ▁RA MP 3 ▁has ▁no ▁de le ter ious ▁effects ▁and ▁seems ▁to ▁confer ▁advantages ▁due ▁to ▁higher ▁than ▁normal ▁b one ▁mass , ▁and ▁reduced ▁weight ▁gain ▁in ▁older ▁age . ▁ ▁References ▁ ▁Further ▁reading ▁ ▁External ▁links ▁▁▁▁▁ ▁Category : End ocr in ology ▁Category : Gen es ▁on ▁human ▁chrom os ome ▁ 1 1 <0x0A> </s> ▁Major