▁no ▁over t ▁phen ot ype ▁in ▁the ▁left ▁vent ric ular ▁my oc ard ium ; ▁however , ▁m ice ▁har bor ing ▁a ▁stabil ized ▁form ▁of ▁beta - c aten in ▁developed ▁dil ated ▁card iom y op ath y , ▁suggesting ▁that ▁the ▁temporal ▁reg ulation ▁of ▁beta - c aten in ▁by ▁protein ▁de grad ation ▁mechan isms ▁is ▁critical ▁for ▁normal ▁function ing ▁of ▁beta - c aten in ▁in ▁card iac ▁cells . ▁In ▁a ▁mouse ▁model ▁har bor ing ▁knock out ▁of ▁a ▁des mos om al ▁protein , ▁pla k og lo bin , ▁imp licated ▁in ▁arr h ythm ogen ic ▁right ▁vent ric ular ▁card iom y op ath y , ▁the ▁stabil ization ▁of ▁beta - c aten in ▁was ▁also ▁en hanced , ▁pres umably ▁to ▁compens ate ▁for ▁the ▁loss ▁of ▁its ▁pla k og lob lin ▁hom olog . ▁These ▁changes ▁were ▁coordinate ▁with ▁Akt ▁activation ▁and ▁g ly c ogen ▁synth ase ▁kin ase ▁ 3 β ▁in hib ition , ▁suggesting ▁once ▁again ▁that ▁the ▁ab normal ▁stabil ization ▁of ▁beta - c aten in ▁may ▁be ▁involved ▁in ▁the ▁development ▁of ▁card iom y op ath y . ▁ ▁Further ▁studies ▁employ ing ▁a ▁double ▁knock out ▁of ▁pla k og lo bin ▁and ▁beta - c aten in ▁showed ▁that ▁the ▁double ▁knock out ▁developed ▁card iom y op ath y , ▁fib ros is ▁and ▁arr h yth mi as ▁resulting ▁in ▁sudden