LE s ▁and ▁R ip T AL s . ▁It ▁is ▁not ▁unexpected ▁that ▁they ▁may ▁differ ▁in ▁bi ological ▁roles ▁from ▁T A LE s ▁and ▁R ip T AL s ▁since ▁the ▁life ▁style ▁of ▁the ▁b acter ium ▁they ▁derive ▁from ▁is ▁very ▁unlike ▁that ▁of ▁T A LE ▁and ▁R ip T AL ▁bearing ▁b acter ia . ▁B . ▁rh iz ox in ica ▁is ▁an ▁end os ym b ion t , ▁living ▁inside ▁a ▁fung us , ▁unlike ▁Rh iz opus ▁micro sp orus , ▁a ▁plant ▁path ogen . ▁The ▁same ▁fung us ▁is ▁also ▁an ▁opportun istic ▁human ▁path ogen ▁in ▁imm uno - comp rom ised ▁patients , ▁but ▁whereas ▁B . ▁rh iz ox in ica ▁is ▁necessary ▁for ▁path ogen icity ▁on ▁plant ▁hosts ▁it ▁is ▁irrelevant ▁to ▁human ▁in fection . ▁ ▁It ▁is ▁unclear ▁whether ▁the ▁Bur k holder ia ▁T A LE - lik es ▁are ▁ever ▁secret ed ▁either ▁into ▁the ▁fung us , ▁let ▁alone ▁into ▁host ▁plants . ▁ ▁Us es ▁in ▁Bi ote chn ology ▁ ▁As ▁noted ▁in ▁the ▁publications ▁on ▁Bur k holder ia ▁T A LE - lik es ▁there ▁may ▁be ▁some ▁advantages ▁to ▁using ▁these ▁prote ins ▁as ▁a ▁sc aff old ▁for ▁program m able ▁DNA - binding ▁prote ins ▁to ▁function ▁as ▁trans cription ▁factors ▁or ▁designer - n uc leases , ▁compared ▁to ▁T A LE s . ▁It ▁has ▁been ▁f used ▁with ▁a ▁F