C ▁ph osph ory lation ▁sites ▁found ▁near ▁the ▁R PE L ▁repe ats . ▁ ▁Function ▁ ▁P HA CT R 1 ▁is ▁a ▁P P 1 ▁binding ▁protein , ▁which ▁is ▁reported ▁to ▁be ▁highly ▁expressed ▁in ▁brain ▁and ▁which ▁controls ▁P P 1 ▁activity ▁and ▁F - act in ▁rem od eling . ▁P HA CT R 1 ▁can ▁be ▁induced ▁by ▁NR P ▁and ▁V EG F ▁through ▁NR P - 1 ▁and ▁V EG F - R 1 ▁re cept ors ▁to ▁control ▁tub ul ogen esis , ▁act in ▁polym er ization , ▁and ▁l am el lip od ial ▁dynamics . ▁Through ▁this ▁function , ▁P HA CT R 1 ▁is ▁suggested ▁to ▁play ▁a ▁role ▁in ▁cell ▁mot ility ▁and ▁v asc ular ▁morph ogen esis . ▁Meanwhile , ▁supp ression ▁of ▁P HA CT R 1 ▁increases ▁expression ▁of ▁death ▁cell ▁re cept ors , ▁leading ▁to ▁extr insic ▁apo pt osis . ▁ ▁The ▁P HA CT R 1 ▁loc us ▁is ▁commonly ▁identified ▁in ▁multiple ▁gen ome - wide ▁association ▁studies ▁investig ating ▁coron ary ▁ar tery ▁disease ▁and ▁my oc ard ial ▁inf ar ction ▁( MI ). ▁However , ▁little ▁is ▁known ▁about ▁the ▁function ▁of ▁P HA CT R 1 ▁in ▁the ▁heart . ▁ ▁C lin ical ▁Sign ific ance ▁ ▁U pre g ulation ▁of ▁P HA CT R 1 ▁by ▁transform ing ▁growth ▁factor ▁( T G F )- β ▁has ▁been ▁described ▁in ▁breast ▁cancer