CL 3 ▁on c ogene , ▁which ▁is ▁at ▁ 1 9 q 1 3 . 1 - q 1 3 . 2 . ▁ ▁Function ▁ ▁The ▁A X L ▁re ceptor ▁trans du ces ▁signals ▁from ▁the ▁ext rac ell ular ▁matrix ▁into ▁the ▁cy top las m ▁by ▁binding ▁growth ▁factors ▁like ▁vit amin ▁K - dependent ▁protein ▁growth - arr est - specific ▁gene ▁ 6 ▁( G AS 6 ). ▁It ▁is ▁involved ▁in ▁the ▁stim ulation ▁of ▁cell ▁pro l ifer ation ▁and ▁surv ival . ▁Prote ol yt ic ▁cle av age ▁of ▁the ▁A X L ▁ext rac ell ular ▁domain ▁by ▁the ▁metal lo prote in ases ▁AD AM 1 0 ▁and ▁AD AM 1 7 ▁can ▁down reg ulate ▁this ▁sign alling ▁activity . ▁ ▁Sign alling ▁path ways ▁activ ated ▁down stream ▁of ▁A X L ▁include ▁P I 3 K - AK T - m T OR , ▁ME K ER K , ▁N F - κ B , ▁and ▁J AK / STAT . ▁ ▁This ▁re ceptor ▁can ▁also ▁medi ate ▁cell ▁aggreg ation ▁by ▁hom oph il ic ▁binding . ▁ ▁A X L ▁protein ▁is ▁expressed ▁in ▁normal ▁t issues , ▁particularly ▁in ▁b one ▁mar row ▁st rom a ▁and ▁my el oid ▁cells , ▁and ▁in ▁tum our ▁cells ▁and ▁tum our ▁vas cul ature . ▁In ▁cancer , ▁A X L ▁is ▁expressed ▁on ▁the ▁tum or ▁cells ▁as ▁well ▁as ▁adjacent ▁imm une