K 2 ▁include ▁using ▁small ▁mole cules ▁( including ▁Par ox et ine ▁and ▁Comp ound - 1 0 1 ) ▁and ▁using ▁gene ▁ther apy ▁approaches ▁util izing ▁regul atory ▁domains ▁of ▁GR K 2 ▁( part icular ly ▁over express ing ▁the ▁car box y ▁terminal ▁ple ck str in - hom ology ▁( PH ) ▁domain ▁that ▁bind s ▁the ▁G ▁protein ▁ β γ - sub unit ▁complex ▁and ▁in hib its ▁GR K 2 ▁activation ▁( o ften ▁called ▁the ▁“ β AR K ct ” ), ▁or ▁just ▁a ▁pe pt ide ▁from ▁this ▁P H ▁domain ). ▁ ▁GR K 2 ▁and ▁the ▁related ▁GR K 3 ▁can ▁interact ▁with ▁heter otr imer ic ▁G ▁protein ▁sub un its ▁resulting ▁from ▁G PC R ▁activation , ▁both ▁to ▁be ▁activ ated ▁and ▁to ▁reg ulate ▁G ▁protein ▁signal ing ▁path ways . ▁GR K 2 ▁and ▁GR K 3 ▁share ▁a ▁car box yl ▁terminal ▁ple ck str in ▁hom ology ▁( PH ) ▁domain ▁that ▁bind s ▁to ▁G ▁protein ▁ β γ ▁sub un its , ▁and ▁G PC R ▁activation ▁of ▁heter otr imer ic ▁G ▁prote ins ▁releases ▁this ▁free ▁ β γ ▁complex ▁that ▁bind s ▁to ▁GR K 2 / 3 ▁to ▁rec ruit ▁these ▁kin ases ▁to ▁the ▁cell ▁memb rane ▁precisely ▁at ▁the ▁location ▁of ▁the ▁activ ated ▁re ceptor , ▁augment ing ▁GR K ▁activity ▁to ▁reg ulate ▁the ▁activ ated ▁re ceptor . ▁The ▁am ino