▁of ▁ad her ens ▁j unction / inter cal ated ▁disc ▁and ▁nuclear ▁po ols ▁of ▁beta - c aten in ▁were ▁decre ased . ▁These ▁data ▁suggest ▁that ▁a ▁loss ▁of ▁beta - c aten in ▁may ▁play ▁a ▁role ▁in ▁the ▁dise ased ▁inter cal ated ▁disc s ▁that ▁have ▁been ▁associated ▁with ▁card iac ▁mus cle ▁hy pert ro phy ▁and ▁heart ▁failure . ▁In ▁a ▁rat ▁model ▁of ▁my oc ard ial ▁inf ar ction , ▁ad en ov iral ▁gene ▁transfer ▁of ▁non ph osph ory lat able , ▁const itut ively - active ▁beta - c aten in ▁decre ased ▁M I ▁size , ▁activ ated ▁the ▁cell ▁cycle , ▁and ▁reduced ▁the ▁amount ▁of ▁apo pt osis ▁in ▁card iom y ocy tes ▁and ▁card iac ▁my of ib ro bl asts . ▁This ▁finding ▁was ▁coordinate ▁with ▁en hanced ▁expression ▁of ▁pro - sur v ival ▁prote ins , ▁surv iv in ▁and ▁B cl - 2 , ▁and ▁v asc ular ▁end oth el ial ▁growth ▁factor ▁while ▁prom oting ▁the ▁different iation ▁of ▁card iac ▁fib ro bl asts ▁into ▁my of ib ro bl asts . ▁These ▁find ings ▁suggest ▁that ▁beta - c aten in ▁can ▁promote ▁the ▁reg ener ation ▁and ▁he aling ▁process ▁following ▁my oc ard ial ▁inf ar ction . ▁In ▁a ▁sp ont ane ously - hy pert ensive ▁heart ▁failure ▁rat ▁model , ▁investig ators ▁detected ▁a ▁sh utt ling ▁of ▁beta - c aten