P 5 3 ▁mut ation ▁in ▁high ▁grade ▁ser ous ▁o var ian ▁cancer ▁( H G SO C ), ▁the ▁most ▁common ▁form ▁of ▁o var ian ▁cancer , ▁which ▁was ▁adopted ▁as ▁a ▁critical ▁marker ▁for ▁diagn osing ▁H G SO C ▁by ▁the ▁World ▁Health ▁Organisation . ▁Br ent on ▁used ▁this ▁T P 5 3 ▁discovery ▁to ▁develop ▁personal ised ▁circul ating ▁tum our ▁DNA ▁ass ays ▁to ▁measure ▁treatment ▁response ▁in ▁o var ian ▁cancer . ▁ ▁In ▁ 2 0 1 5 , ▁his ▁team ▁was ▁the ▁first ▁to ▁measure ▁the ▁tum our ▁heter ogene ity ▁in ▁a ▁solid ▁tum our ▁and ▁link ▁this ▁to ▁cancer ▁surv ival , ▁finding ▁that ▁H G SO C ▁was ▁more ▁dead ly ▁if ▁it ▁consisted ▁of ▁a ▁patch work ▁of ▁different ▁groups ▁of ▁cells . ▁ ▁In ▁ 2 0 1 8 , ▁Br ent on ▁published ▁the ▁first ▁national ▁effort ▁to ▁investigate ▁cancer ▁evolution ▁in ▁H G SO C , ▁discover ing ▁seven ▁distinct ▁gen etic ▁patterns ▁that ▁could ▁predict ▁disease ▁behaviour ▁in ▁response ▁to ▁treatment . ▁This ▁led ▁to ▁the ▁B ri T RO C - 2 ▁study , ▁fund ed ▁by ▁O var ian ▁Can cer ▁Action , ▁to ▁create ▁new , ▁personal ised ▁treat ments ▁for ▁women ▁with ▁H G SO C . ▁ ▁References ▁▁ ▁Category : L iving ▁people <0x0A> </s> ▁David ▁G w yn ne ▁She ph erd ▁( Oct ober ▁ 1 0 , ▁ 1 9 2 4 ▁– ▁December ▁