▁further ▁testing . ▁ ▁Classification ▁Three ▁major ▁groups ▁of ▁M SI - H ▁( mic ros at ellite ▁inst ability ▁– ▁M SI ) ▁can cers ▁can ▁be ▁recognized ▁by ▁hist op ath ological ▁criteria : ▁ ▁right - s ided ▁poor ly ▁differenti ated ▁can cers ▁ ▁right - s ided ▁m uc in ous ▁can cers ▁ ▁ad en oc arc in omas ▁in ▁any ▁location ▁showing ▁any ▁meas urable ▁level ▁of ▁int ra ep ith el ial ▁l ym ph ocy te ▁( T IL ) ▁ ▁In ▁addition , ▁H NP CC ▁can ▁be ▁divided ▁into ▁Lyn ch ▁synd rome ▁I ▁( famil ial ▁colon ▁cancer ) ▁and ▁Lyn ch ▁synd rome ▁II ▁( H NP CC ▁associated ▁with ▁other ▁can cers ▁of ▁the ▁g astro int est inal ▁tract ▁or ▁re product ive ▁system ). ▁ ▁Pre vention ▁After ▁reporting ▁a ▁null ▁finding ▁from ▁their ▁random ized ▁controlled ▁trial ▁of ▁asp ir in ▁( ac et yl sal icy lic ▁acid ▁– ▁AS A ) ▁to ▁prevent ▁the ▁col ore ct al ▁ne op las ia ▁of ▁Lyn ch ▁synd rome , ▁Burn ▁and ▁colle agues ▁have ▁reported ▁new ▁data , ▁representing ▁a ▁longer ▁follow - up ▁period ▁than ▁reported ▁in ▁the ▁initial ▁NE J M ▁paper . ▁These ▁new ▁data ▁demonstrate ▁a ▁reduced ▁inc idence ▁in ▁people ▁with ▁Lyn ch ▁synd rome ▁who ▁were ▁exposed ▁to ▁at ▁least ▁four ▁years ▁of ▁high - d ose ▁asp ir in , ▁with ▁a ▁satisf actory ▁risk ▁profile . ▁These