gress ▁of ▁imm une ▁cells ▁from ▁the ▁l ym ph oid ▁org ans ▁( such ▁as ▁th ym us ▁and ▁l ym ph ▁nodes ) ▁into ▁the ▁l ym ph atic ▁vessels . ▁In hib ition ▁of ▁S 1 P ▁re cept ors ▁was ▁shown ▁to ▁be ▁critical ▁for ▁imm un om od ulation . ▁S 1 P ▁has ▁also ▁been ▁shown ▁to ▁directly ▁suppress ▁T LR ▁medi ated ▁imm une ▁response ▁from ▁T ▁cells . ▁ ▁A ▁research ▁team , ▁led ▁by ▁a ▁scient ist ▁at ▁We ill ▁Corn ell ▁Medical ▁College , ▁has ▁discovered ▁that ▁red ▁blood ▁cells ▁perform ▁a ▁second ▁vital ▁function : ▁ang i ogen esis ▁Given ▁its ▁role ▁in ▁creating ▁new ▁blood ▁vessels , ▁scient ists ▁recognize ▁S 1 P ▁as ▁vital ▁to ▁human ▁health ▁— ▁and ▁a ▁player ▁in ▁some ▁dise ases , ▁such ▁as ▁cancer . ▁And ▁although ▁S 1 P ▁is ▁known ▁to ▁be ▁blood ▁bor ne , ▁no ▁one ▁realized ▁until ▁this ▁study ▁that ▁S 1 P ▁is ▁supplied ▁by ▁red ▁blood ▁cells ▁to ▁control ▁blood ▁vessel ▁growth . ▁ ▁C lin ical ▁significance ▁The ▁levels ▁of ▁S 1 P ▁( in ▁a ▁range ▁of ▁ 5 – 4 0 ▁ µ m ol / L ) ▁are ▁ 5 ▁to ▁ 1 0 ▁times ▁up - reg ulated ▁in ▁o var ian ▁cancer ▁patients ' ▁asc ites . ▁S 1 P ▁at ▁this ▁phys i ological ▁concentration ▁stim ul ates ▁migration ▁and ▁invasion ▁of ▁ep ith el ial ▁o var ian ▁cancer ▁cells