▁of ▁Ali ▁who ▁had ▁invited ▁Ali ' s ▁son ▁and ▁Muhammad ' s ▁grand son ▁Hus ay n ▁to ▁stage ▁a ▁revol t ▁against ▁Um ay y ad ▁rule ▁from ▁Ira q . ▁An ▁army ▁mobil ized ▁by ▁Ira q ' s ▁governor ▁U bay d ▁Al lah ▁intercept ed ▁and ▁killed ▁Hus ay n ▁outside ▁K uf a ▁at ▁the ▁Battle ▁of ▁Kar b ala . ▁Although ▁it ▁st ym ied ▁active ▁opposition ▁to ▁Y az id ▁in ▁Ira q , ▁the ▁killing ▁of ▁Muhammad ' s ▁grand son ▁left ▁many ▁Muslim s ▁out rag ed ▁and ▁significantly ▁increased ▁K uf an ▁host ility ▁toward ▁the ▁Um ay y ads ▁and ▁sympathy ▁for ▁the ▁family ▁of ▁Ali . ▁ ▁The ▁next ▁major ▁challenge ▁to ▁Y az id ' s ▁rule ▁em an ated ▁from ▁the ▁He j az ▁where ▁Abd ▁Al lah ▁ibn ▁al - Z ub ay r , ▁the ▁son ▁of ▁al - Z ub ay r ▁ibn ▁al - A ww am ▁and ▁grand son ▁of ▁Ab u ▁Bak r , ▁advoc ated ▁for ▁a ▁sh ura ▁among ▁the ▁Q ur ay sh ▁to ▁elect ▁the ▁cal i ph ▁and ▁r al lied ▁opposition ▁to ▁the ▁Um ay y ads ▁from ▁his ▁headquarters ▁in ▁Islam ' s ▁h oli est ▁san ctu ary , ▁the ▁Ka ' aba ▁in ▁Me cca . ▁The ▁Ans ar ▁and ▁Q ur ay sh ▁of ▁Med ina ▁also ▁took ▁up ▁the ▁anti - U may y ad ▁cause ▁and ▁in ▁ 6 8