esis ▁in ▁their ▁approach ▁to ▁synth es ize ▁novel ▁of ▁py rid yl ▁and ▁th ia zo yl ▁bis am ide ▁C SF - 1 R ▁in hib itors ▁for ▁use ▁in ▁novel ▁cancer ▁th era pe ut ics . ▁A ▁couple ▁of ▁the ▁comp ounds ▁that ▁were ▁anal ys ed ▁for ▁in ▁v ivo ▁anti - can cer ▁activity ▁contained ▁th ia z ole ▁derivatives ▁that ▁had ▁been ▁synth es ized ▁using ▁a ▁Cook - He il br on ▁approach . ▁For ▁instance , ▁ 2 - m eth yl - 5 - amin oth ia z oles ▁were ▁prepared ▁via ▁cond ens ation ▁and ▁cycl ization ▁of ▁am ino ac eton it rile ▁and ▁eth y ld ith io ac et ate ▁as ▁part ▁of ▁the ▁synth esis ▁of ▁th ia z ol yl ▁bis am ines : ▁ ▁Re lev ance ▁ ▁Th ia z oles ▁are ▁essential ▁components ▁of ▁many ▁bi olog ically ▁active ▁comp ounds ▁making ▁them ▁important ▁features ▁in ▁drug ▁design . ▁Th ia z oles ▁are ▁found ▁in ▁a ▁number ▁of ▁ph arm ac ological ▁comp ounds ▁such ▁as ▁t ia z of ur in ▁and ▁das atin ib ▁( antine op last ic ▁agents ), ▁rit on av ir ▁( an ▁anti - H IV ▁drug ), ▁ra vu con az ole ▁( ant if ung al ▁agent ), ▁mel ox ic am ▁and ▁f ent ia z ac ▁( anti - infl am mat ory ▁agents ) ▁and ▁n iz at id ine ▁(