▁the ▁H IST 1 H 4 H ▁gene . ▁ ▁Hist ones ▁are ▁basic ▁nuclear ▁prote ins ▁that ▁are ▁responsible ▁for ▁the ▁nucle os ome ▁structure ▁of ▁the ▁chrom os om al ▁fi ber ▁in ▁e uk ary otes . ▁Two ▁mole cules ▁of ▁each ▁of ▁the ▁four ▁core ▁hist ones ▁( H 2 A , ▁H 2 B , ▁H 3 , ▁and ▁H 4 ) ▁form ▁an ▁oct amer , ▁around ▁which ▁approximately ▁ 1 4 6 ▁b p ▁of ▁DNA ▁is ▁wrapped ▁in ▁repeating ▁units , ▁called ▁nucle os om es . ▁The ▁linker ▁hist one , ▁H 1 , ▁interact s ▁with ▁linker ▁DNA ▁between ▁nucle os om es ▁and ▁functions ▁in ▁the ▁comp action ▁of ▁chrom atin ▁into ▁higher ▁order ▁▁ ▁structures . ▁This ▁gene ▁is ▁intr on less ▁and ▁enc odes ▁a ▁member ▁of ▁the ▁hist one ▁H 4 ▁family . ▁Trans cript s ▁from ▁this ▁gene ▁lack ▁poly A ▁t ails ▁but ▁instead ▁contain ▁a ▁pal ind rom ic ▁term ination ▁element . ▁This ▁gene ▁is ▁found ▁in ▁the ▁large ▁hist one ▁gene ▁cluster ▁on ▁chrom os ome ▁ 6 . ▁ ▁References ▁ ▁Further ▁reading <0x0A> </s> ▁John ▁I ▁San udo ▁( or ▁Giovanni ; ▁died ▁ 1 3 6 2 ) ▁was ▁the ▁sixth ▁Duke ▁of ▁the ▁Arch ip el ago ▁from ▁ 1 3 4 1 ▁to ▁his ▁death . ▁ ▁He ▁was ▁the ▁brother ▁and ▁successor ▁of ▁Nicholas ▁I ▁and ▁son ▁of ▁William ▁I . ▁His ▁other ▁brother ▁was ▁Marco ▁San udo