ion , ▁and ▁information ▁processing ▁in ▁neur onal ▁cells . ▁Over all , ▁D AG ▁and ▁IP 3 ▁signal ing ▁has ▁imp lications ▁for ▁neur onal ▁pl astic ity , ▁impact ing ▁hi pp oc amp al ▁long ▁term ▁pot enti ation , ▁stress - indu ced ▁cogn itive ▁imp air ment , ▁and ▁neur onal ▁growth ▁cone ▁spread ing . ▁Furthermore , ▁not ▁only ▁is ▁P IP 2 ▁a ▁prec ursor ▁to ▁several ▁signal ing ▁mole cules , ▁it ▁can ▁be ▁ph osph ory l ated ▁at ▁the ▁ 3 ’ ▁position ▁to ▁become ▁P IP 3 , ▁which ▁is ▁involved ▁in ▁cell ▁pro l ifer ation , ▁apo pt osis ▁and ▁cell ▁movement . ▁ ▁In ▁this ▁path way , ▁I MP ase ▁is ▁the ▁common , ▁final ▁step ▁in ▁rec y cling ▁IP 3 ▁to ▁produce ▁P IP 2 . ▁I MP ase ▁does ▁this ▁by ▁de ph osph ory l ating ▁in os it ol ▁mon oph osph ate ▁to ▁produce ▁in organ ic ▁ph osph ate ▁and ▁my o - inos it ol , ▁the ▁prec ursor ▁to ▁P IP 2 . ▁Because ▁of ▁I MP ase ' s ▁cru cial ▁role ▁in ▁this ▁signal ing ▁path way , ▁it ▁is ▁a ▁potential ▁drug ▁target ▁for ▁in hib ition ▁and ▁mod ulation . ▁ ▁I MP ase ▁in ▁the ▁de ▁nov o ▁synth esis ▁of ▁my o - inos it ol ▁ ▁There ▁are ▁at ▁least ▁ 2 ▁known ▁steps ▁in ▁the ▁de ▁nov o ▁synth esis ▁of