▁versus ▁ 2 5 % ), ▁th rom b oc yt open ia ▁( low ▁plate let ▁count ; ▁ 2 8 % ▁versus ▁ 1 4 % ), ▁peri pher al ▁ne urop ath y ▁( 2 8 % ▁versus ▁ 2 1 % ), ▁n ause a ▁( 2 6 % ▁versus ▁ 2 1 % ), ▁peri pher al ▁o ed ema ▁( sw elling ; ▁ 2 5 % ▁versus ▁ 1 8 % ), ▁vom iting ▁( 2 2 % ▁versus ▁ 1 1 % ), ▁and ▁back ▁pain ▁( 2 1 % ▁versus ▁ 1 6 %). ▁Ser ious ▁di arr ho ea ▁or ▁th rom b oc yt open ia ▁occurred ▁in ▁ 2 % ▁of ▁patients , ▁respectively . ▁ ▁Side ▁effects ▁of ▁i x az om ib ▁alone ▁were ▁only ▁ass essed ▁in ▁a ▁small ▁number ▁of ▁people . ▁Di arr ho ea ▁grade ▁ 2 ▁or ▁higher ▁was ▁found ▁in ▁ 2 4 % ▁of ▁these ▁patients , ▁th rom b oc yt open ia ▁grade ▁ 3 ▁or ▁higher ▁in ▁ 2 8 %, ▁and ▁fat igue ▁grade ▁ 2 ▁or ▁higher ▁in ▁ 2 6 %. ▁ ▁Inter actions ▁▁ ▁The ▁drug ▁has ▁a ▁low ▁potential ▁for ▁interactions ▁via ▁cy to chrome ▁P 4 5 0 ▁( C Y P ) ▁li ver ▁en zym es ▁and ▁trans porter ▁prote ins . ▁The ▁only ▁relevant ▁finding ▁in ▁studies ▁was ▁a ▁reduction ▁of ▁i x az om ib ▁blood ▁levels ▁when ▁combined