▁at ▁rest ▁in ▁D L B ▁than ▁in ▁P D , ▁and ▁signs ▁of ▁par kin son ism ▁in ▁D L B ▁are ▁more ▁symmet rical . ▁In ▁M SA , ▁autonom ic ▁d ys function ▁appears ▁earlier ▁and ▁is ▁more ▁severe , ▁and ▁is ▁accompanied ▁by ▁un co ordin ated ▁movements , ▁while ▁visual ▁hall uc in ations ▁and ▁fl uct u ating ▁cogn ition ▁are ▁less ▁common ▁than ▁in ▁D L B . ▁ ▁Ur inary ▁difficulties ▁are ▁one ▁of ▁the ▁earliest ▁sympt oms ▁with ▁M SA , ▁and ▁are ▁often ▁severe . ▁ ▁DNA ▁damage ▁ ▁Al pha - syn uc lein ▁mod ul ates ▁DNA ▁repair ▁processes , ▁including ▁the ▁repair ▁of ▁DNA ▁double - str and ▁breaks ▁by ▁the ▁non - hom olog ous ▁end ▁joining ▁path way . ▁ ▁The ▁DNA ▁repair ▁function ▁of ▁alpha - syn uc lein ▁appears ▁to ▁be ▁comprom ised ▁in ▁Lew y ▁body ▁inclusion ▁bearing ▁neur ons , ▁and ▁this ▁may ▁trigger ▁cell ▁death . ▁ ▁Study ▁of ▁syn uc lein op ath y ▁mouse ▁models ▁of ▁Park inson ’ s ▁disease ▁indicates ▁that ▁alpha - syn uc lein ▁path ogen esis ▁is ▁associated ▁with ▁increased ▁DNA ▁damage ▁and ▁activation ▁of ▁the ▁DNA ▁damage ▁response . ▁ ▁See ▁also ▁ ▁Prote op ath y ▁ ▁Lew y ▁body ▁ ▁References ▁ ▁Category : L ew y ▁body ▁de ment ia ▁Category : Ne uro log ical ▁dis orders <0x0A> </s> ▁Jules ▁Eug ène ▁Louis ▁J ouv et ▁( 2 4 ▁December ▁