res . ▁However , ▁Ch rom os ome ▁Con formation ▁Capt ure ▁( 3 C ) ▁methods ▁revealed ▁that ▁the ▁decay ▁of ▁contacts ▁with ▁the ▁genom ic ▁distance ▁in ▁inter phase ▁chrom os om es ▁is ▁pract ically ▁the ▁same ▁as ▁in ▁the ▁cr um ple d ▁glob ule ▁state ▁that ▁is ▁formed ▁when ▁long ▁polym ers ▁con den se ▁without ▁formation ▁of ▁any ▁kn ots . ▁To ▁remove ▁kn ots ▁from ▁highly ▁crow ded ▁chrom atin , ▁one ▁would ▁need ▁an ▁active ▁process ▁that ▁should ▁not ▁only ▁provide ▁the ▁energy ▁to ▁move ▁the ▁system ▁from ▁the ▁state ▁of ▁topological ▁equilibrium ▁but ▁also ▁guide ▁to pois omer ase - medi ated ▁pass ages ▁in ▁such ▁a ▁way ▁that ▁kn ots ▁would ▁be ▁efficiently ▁un k not ted ▁instead ▁of ▁making ▁the ▁kn ots ▁even ▁more ▁complex . ▁It ▁has ▁been ▁shown ▁that ▁the ▁process ▁of ▁chrom atin - loop ▁extr usion ▁is ▁ide ally ▁su ited ▁to ▁act ively ▁un k not ▁chrom atin ▁fib res ▁in ▁inter phase ▁chrom os om es . ▁ ▁Ch rom atin : ▁alternative ▁definitions ▁ ▁The ▁term , ▁introduced ▁by ▁Wal ther ▁F lem ming , ▁has ▁multiple ▁mean ings : ▁ ▁Simple ▁and ▁conc ise ▁definition : ▁Ch rom atin ▁is ▁a ▁mac rom ole cular ▁complex ▁of ▁a ▁DNA ▁mac rom ole c ule ▁and ▁protein ▁mac rom ole cules ▁( and ▁R NA ). ▁The ▁prote ins ▁package ▁and ▁ar range ▁the ▁DNA ▁and ▁control ▁its ▁functions ▁within ▁the ▁cell ▁nucle us .