9 5 4 . ▁It ▁was ▁the ▁result ▁of ▁a ▁search ▁by ▁Thom ä ▁and ▁W ick ▁for ▁an ▁an ore ctic ▁drug ▁without ▁the ▁side - effect s ▁of ▁am ph et am ine . ▁Ph en met raz ine ▁was ▁introduced ▁into ▁clin ical ▁use ▁in ▁ 1 9 5 4 ▁in ▁Europe . ▁ ▁Medical ▁use ▁ ▁In ▁clin ical ▁use , ▁phen met raz ine ▁produces ▁less ▁nerv ous ness , ▁hyp ere x cit ability , ▁eu ph oria ▁and ▁ins om nia ▁than ▁dru gs ▁of ▁the ▁am ph et am ine ▁family . ▁It ▁tends ▁not ▁to ▁increase ▁heart ▁rate ▁as ▁much ▁as ▁other ▁stim ul ants . ▁Due ▁to ▁the ▁relative ▁lack ▁of ▁side ▁effects , ▁one ▁study ▁found ▁it ▁well ▁toler ated ▁in ▁children . ▁In ▁a ▁study ▁of ▁the ▁effect iveness ▁on ▁weight ▁loss ▁between ▁phen met raz ine ▁and ▁de xt ro am ph et am ine , ▁phen met raz ine ▁was ▁found ▁to ▁be ▁slightly ▁more ▁effective . ▁ ▁Ph arm ac ology ▁ ▁Ph en met raz ine ▁acts ▁as ▁a ▁re le asing ▁agent ▁of ▁n ore pine phr ine ▁and ▁dop am ine ▁with ▁EC 5 0 ▁values ▁of ▁ 5 0 . 4 ▁ ± ▁ 5 . 4 ▁n M ▁and ▁ 1 3 1 ▁ ± ▁ 1 1 ▁n M , ▁respectively . ▁It ▁has ▁neg lig ible ▁effic acy ▁as ▁a ▁re le aser ▁of ▁ser ot on in , ▁with ▁an