▁reduces ▁est ro gen ▁production ▁and ▁levels , ▁it ▁has ▁functional ▁anti estro gen ic ▁properties . ▁The ▁combination ▁of ▁its ▁anti estro gen ic , ▁and ro gen ic , ▁and ▁pro gest ogen ic ▁or ▁ant ip ro gest ogen ic ▁actions ▁cause ▁at ro phy ▁of ▁the ▁end omet rium , ▁which ▁alle vi ates ▁the ▁sympt oms ▁of ▁end omet rios is . ▁ ▁Effect s ▁in ▁men ▁In ▁men , ▁dan az ol ▁has ▁been ▁found ▁to ▁in hib it ▁g on ad otrop in ▁secret ion ▁and ▁marked ly ▁decrease ▁test oster one ▁levels , ▁likely ▁due ▁to ▁its ▁actions ▁as ▁a ▁ster oid ogen esis ▁in hib itor ▁and ▁ant ig on ad otrop in . ▁However , ▁even ▁at ▁the ▁highest ▁dos age ▁ass essed ▁( 8 0 0   m g / day ), ▁s per mat ogen esis ▁remained ▁una ffect ed . ▁ ▁Ph arm ac ok inet ics ▁The ▁bio av ail ability ▁of ▁dan az ol ▁is ▁low . ▁In ▁addition , ▁circul ating ▁levels ▁of ▁dan az ol ▁do ▁not ▁increase ▁proportion ally ▁with ▁increasing ▁dos es , ▁indicating ▁that ▁there ▁is ▁a ▁s atur ation ▁of ▁bio av ail ability . ▁With ▁single - d ose ▁administration , ▁it ▁has ▁been ▁found ▁that ▁a ▁ 4 - fold ▁increase ▁in ▁dos age ▁of ▁dan az ol ▁increased ▁peak ▁levels ▁only ▁by ▁ 1 . 3 - ▁and ▁ 2 . 2 - fold ▁and ▁area - under -