eto ac idos is ▁than ▁patients ▁with ▁P ND M . ▁T ND M ▁patients ▁are ▁younger ▁at ▁the ▁age ▁of ▁diagn osis ▁of ▁di ab etes ▁and ▁have ▁lower ▁ins ul in ▁requirements , ▁an ▁overlap ▁occurs ▁ ▁between ▁the ▁two ▁groups , ▁therefore ▁T ND M ▁cannot ▁be ▁distinguished ▁from ▁P ND M ▁based ▁clin ical ▁feature . ▁An ▁early ▁on set ▁of ▁di ab etes ▁m ell it us ▁is ▁un related ▁to ▁auto imm unity ▁in ▁most ▁cases , ▁re lapse ▁of ▁di ab etes ▁is ▁common ▁with ▁T ND M , ▁and ▁extensive ▁follow ▁ups ▁are ▁important . ▁In ▁addition , ▁mole cular ▁analysis ▁of ▁chrom os om es ▁ 6 ▁ ▁defect s , ▁ ▁K CN J 1 1 ▁and ▁AB CC 8 ▁gen es ▁( encoding ▁Kir 6 . 2 ▁and ▁S UR 1 ) ▁provide ▁a ▁way ▁to ▁identify ▁P ND M ▁in ▁the ▁infant ▁stages . ▁Appro xim ately , 5 0 % ▁of ▁P ND M ▁are ▁associated ▁with ▁the ▁pot ass ium ▁channel ▁defect s ▁which ▁are ▁essential ▁consequences ▁when ▁changing ▁patients ▁from ▁ins ul in ▁ther apy ▁to ▁sul fony l ure as . ▁ ▁T ND M ▁Di agn osis ▁associated ▁with ▁Ch rom os ome ▁ 6 q 2 4 ▁Mut ations ▁ ▁The ▁un ip ar ental ▁dis omy ▁of ▁the ▁chrom os ome ▁ ▁can ▁be ▁used ▁as ▁di agnostic ▁method ▁provide ▁proof ▁by ▁the ▁analysis ▁of ▁polym orph ic ▁markers ▁is ▁present ▁on ▁Ch rom