es bury ' s ▁son ▁and ▁names ake , ▁Anthony ▁Ash ley - Co oper . ▁Through ▁his ▁marriage ▁to ▁the ▁former ▁Frances ▁Cec il , ▁Sh aft es bury ▁acquired ▁property ▁at ▁Ex eter ▁House , ▁also ▁known ▁as ▁Cec il ▁House ▁in ▁London . ▁It ▁was ▁here ▁that ▁the ▁phil os opher , ▁John ▁Lock e ▁res ided ▁from ▁ 1 6 6 6 ▁to ▁ 1 6 8 8 , ▁while ▁serving ▁as ▁Sh aft es bury ' s ▁personal ▁phys ician , ▁secretary , ▁research er , ▁political ▁oper ative , ▁and ▁friend . ▁While ▁living ▁with ▁him , ▁Lock e ▁became ▁drawn ▁into ▁the ▁heart ▁of ▁English ▁politics ▁in ▁the ▁ 1 6 7 0 s ▁and ▁ 1 6 8 0 s . ▁ ▁Sh aft es bury ' s ▁third ▁wife ▁was ▁Margaret , ▁daughter ▁of ▁William ▁Sp encer , ▁ 2 nd ▁Baron ▁Sp encer ▁of ▁W orm le ight on . ▁Margaret ' s ▁mother ▁was ▁Pen el ope , ▁first ▁daughter ▁of ▁Henry ▁W ri oth es ley , ▁ 3 rd ▁Earl ▁of ▁South am pton . ▁Margaret , ▁Count ess ▁of ▁Sh aft es bury , ▁was ▁the ▁mother ▁of ▁Ash ley - Co oper ' s ▁two ▁daughters , ▁Pen el ope ▁and ▁Lu cret ia . ▁While ▁Bur ke ' s ▁Pe er age ▁states ▁that ▁Ash ley - Co oper ▁had ▁only ▁one ▁child , ▁son ▁and ▁he ir ▁Anthony ▁Jr , ▁Ash ley - Co oper '