▁critical ▁to ▁the ▁stability ▁of ▁the ▁fib re , ▁requiring ▁nucle os om es ▁to ▁be ▁separated ▁by ▁lengths ▁that ▁permit ▁rotation ▁and ▁fol ding ▁into ▁the ▁required ▁orientation ▁without ▁excess ive ▁stress ▁to ▁the ▁DNA . ▁In ▁this ▁view , ▁different ▁lengths ▁of ▁the ▁linker ▁DNA ▁should ▁produce ▁different ▁fol ding ▁top ologies ▁of ▁the ▁chrom atin ▁fi ber . ▁Rec ent ▁theoretical ▁work , ▁based ▁on ▁electron - m icro sc opy ▁images ▁of ▁reconst it uted ▁fib ers ▁supports ▁this ▁view . ▁ ▁Sp atial ▁organization ▁of ▁chrom atin ▁in ▁the ▁cell ▁nucle us ▁ ▁The ▁spatial ▁arrangement ▁of ▁the ▁chrom atin ▁within ▁the ▁nucle us ▁is ▁not ▁random ▁- ▁specific ▁regions ▁of ▁the ▁chrom atin ▁can ▁be ▁found ▁in ▁certain ▁territ ories . ▁Territ ories ▁are , ▁for ▁example , ▁the ▁l am ina - associ ated ▁domains ▁( L AD s ), ▁and ▁the ▁top olog ically ▁associ ating ▁domains ▁( T AD s ), ▁which ▁are ▁bound ▁together ▁by ▁protein ▁complex es . ▁Currently , ▁polym er ▁models ▁such ▁as ▁the ▁Str ings ▁& ▁Bind ers ▁Switch ▁( SB S ) ▁model ▁and ▁the ▁Dynamic ▁Loop ▁( DL ) ▁model ▁are ▁used ▁to ▁describe ▁the ▁fol ding ▁of ▁chrom atin ▁within ▁the ▁nucle us . ▁ ▁Cell - cycle ▁dependent ▁struct ural ▁organization ▁▁ ▁Inter phase : ▁The ▁structure ▁of ▁chrom atin ▁during ▁inter phase ▁of ▁mit osis ▁is ▁optimized ▁to ▁allow ▁simple ▁access ▁of ▁trans cription ▁and ▁DNA ▁repair ▁factors ▁to ▁the ▁DNA ▁while ▁compact ing