▁been ▁found ▁to ▁be ▁in hib ited . ▁ ▁For ▁reference , ▁circul ating ▁concentr ations ▁of ▁dan az ol ▁are ▁in ▁the ▁range ▁of ▁ 2   μ M ▁at ▁a ▁dos age ▁of ▁ 6 0 0   m g / day ▁in ▁women . ▁ ▁Occ up ation ▁and ▁down reg ulation ▁of ▁car rier ▁prote ins ▁ ▁Dan az ol ▁is ▁known ▁to ▁bind ▁to ▁two ▁ster oid ▁h orm one ▁car rier ▁prote ins : ▁sex ▁h orm one - binding ▁glob ul in ▁( SH B G ), ▁which ▁bind s ▁and rog ens ▁and ▁est rog ens ; ▁and ▁cort ic ost ero id - binding ▁glob ul in ▁( CB G ), ▁which ▁bind s ▁pro g ester one ▁and ▁cort is ol . ▁Binding ▁of ▁dan az ol ▁to ▁SH B G ▁is ▁considered ▁to ▁be ▁more ▁important ▁clin ically . ▁By ▁occup ying ▁SH B G ▁and ▁C B G , ▁dan az ol ▁increases ▁the ▁ratio ▁of ▁free ▁to ▁pl asma ▁protein - bound ▁test oster one , ▁est rad i ol , ▁pro g ester one , ▁and ▁cort is ol . ▁The ▁table ▁to ▁the ▁right ▁shows ▁the ▁difference ▁in ▁test oster one ▁levels ▁in ▁pre men op aus al ▁women ▁treated ▁with ▁dan az ol . ▁ ▁As ▁can ▁be ▁seen , ▁the ▁percentage ▁of ▁free ▁test oster one ▁is ▁triple d ▁in ▁women ▁being ▁treated ▁with ▁dan az ol . ▁The ▁ability ▁of ▁dan az ol ▁to ▁increase