c aten in : ▁the ▁ β - Tr CP ▁binding ▁mot if . ▁L oss - of - function ▁mut ations ▁of ▁this ▁mot if ▁essentially ▁make ▁u bi quit in yl ation ▁and ▁de grad ation ▁of ▁ β - c aten in ▁impossible . ▁It ▁will ▁cause ▁ β - c aten in ▁to ▁trans loc ate ▁to ▁the ▁nucle us ▁without ▁any ▁external ▁stim ulus ▁and ▁continu ously ▁drive ▁trans cription ▁of ▁its ▁target ▁gen es . ▁In cre ased ▁nuclear ▁ β - c aten in ▁levels ▁have ▁also ▁been ▁noted ▁in ▁bas al ▁cell ▁car cin oma ▁( B CC ), ▁head ▁and ▁neck ▁squ am ous ▁cell ▁car cin oma ▁( H NS CC ), ▁pro state ▁cancer ▁( Ca P ), ▁pil om at rix oma ▁( P TR ) ▁and ▁med ul lob last oma ▁( M DB ) ▁These ▁observations ▁may ▁or ▁may ▁not ▁imp licate ▁a ▁mut ation ▁in ▁the ▁ β - c aten in ▁gene : ▁other ▁W nt ▁path way ▁components ▁can ▁also ▁be ▁fault y . ▁ ▁Similar ▁mut ations ▁are ▁also ▁frequently ▁seen ▁in ▁the ▁ β - c aten in ▁rec ruit ing ▁mot ifs ▁of ▁A PC . ▁Her edit ary ▁loss - of - function ▁mut ations ▁of ▁A PC ▁cause ▁a ▁condition ▁known ▁as ▁Famil ial ▁A den om at ous ▁Poly pos is . ▁A ffect ed ▁individuals ▁develop ▁hundreds ▁of ▁poly ps ▁in ▁their ▁large ▁int est ine . ▁Most ▁of