▁of ▁the ▁B eta - cell ▁memb rane . ▁De pol ar ization ▁is ▁the ▁loss ▁of ▁the ▁difference ▁in ▁charge ▁between ▁the ▁inner ▁and ▁outer ▁parts ▁of ▁the ▁pl asma ▁memb rane ▁of ▁a ▁mus cle . ▁This ▁occurs ▁because ▁of ▁change ▁in ▁per me ability ▁and ▁migration ▁of ▁sod ium ▁ ions ▁inside ▁the ▁cell . ▁The ▁voltage ▁g ated ▁channels ▁then ▁open , ▁allowing ▁calci um ▁( Ca +) ▁to ▁flow ▁inside ▁the ▁channel ▁and ▁cause ▁ ▁ex oc yt osis ▁( active ▁transport ▁that ▁moves ▁mole cules ▁out ▁of ▁a ▁cell ▁by ▁e ject ing ▁them ▁in ▁an ▁energy ▁using ▁process ) ▁of ▁ins ul in - cont aining ▁gran ules ▁from ▁the ▁B eta - cell s . ▁Activ ation ▁of ▁defect s ▁in ▁K CN J 1 1 ▁or ▁AB CC 8 ▁seems ▁to ▁make ▁the ▁K AT P ▁channel ▁less ▁sensitive ▁to ▁ATP , ▁leaving ▁more ▁channels ▁in ▁an ▁open ▁state ▁after ▁high ▁levels ▁of ▁gl uc ose ▁occurs . ▁Result ing ▁in ▁the ▁failure ▁of ▁ins ul in ▁response ▁to ▁high ▁blood ▁gl uc ose ▁and ▁leading ▁to ▁N DM . ▁ ▁Di agn osis ▁ ▁Di agn osis ▁of ▁T ND M ▁and ▁P ND M ▁ ▁The ▁di agnostic ▁evalu ations ▁are ▁based ▁upon ▁current ▁literature ▁and ▁research ▁available ▁on ▁N DM . ▁The ▁following ▁evaluation ▁factors ▁are : ▁patients ▁with ▁T ND M ▁are ▁more ▁likely ▁to ▁have ▁int ra uter ine ▁growth ▁ret ard ation ▁and ▁less ▁likely ▁to ▁develop ▁k