ite ▁and ▁minim ize ▁its ▁damage ▁to ▁the ▁gut . ▁In ▁addition , ▁these ▁cells ▁are ▁important ▁in ▁increasing ▁contra ctions ▁of ▁the ▁gut ▁wall , ▁which ▁facil it ates ▁w orm ▁exp ulsion . ▁The ▁s ple en , ▁m esent er ic ▁l ym ph ▁nodes , ▁P ey er ’ s ▁patch es , ▁and ▁l am ina ▁prop ria ▁l ym ph ocy tes ▁indu ce ▁a ▁strong ▁Th 2 ▁imm une ▁response ▁by ▁producing ▁different ▁cy tok ines ▁( Inter le uk in ▁ 3 , ▁IL 4 , ▁IL 5 , ▁IL 9 , ▁IL 1 0 , ▁and ▁IL 1 3 ), ▁which ▁are ▁important ▁in ▁cont rolling ▁and ▁exp elling ▁w orm s . ▁These ▁cy tok ines ▁aid ▁in ▁generating ▁CD 4 ▁T ▁helper ▁ 2 ▁effect or ▁cells ▁necessary ▁for ▁adapt ive ▁imm une ▁responses ▁against ▁the ▁par as ite . ▁In ▁addition , ▁cost im ul atory ▁signals ▁via ▁CD 8 0 ▁and ▁CD 8 6 ▁have ▁also ▁be ▁shown ▁important ▁in ▁mount ing ▁a ▁Th 2 ▁imm une ▁response ▁and ▁producing ▁imm un og lob ul in ▁E ▁( Ig E ). ▁In ▁the ▁hum oral ▁arm ▁of ▁imm unity , ▁par as ite - specific ▁Ig G 1 ▁plays ▁a ▁greater ▁role ▁in ▁protection ▁during ▁in fection , ▁and ▁Ig A ▁has ▁been ▁shown ▁to ▁have ▁a ▁minor ▁effect . ▁ ▁Ig M ▁and ▁Ig E ▁have ▁not ▁been ▁shown ▁to ▁be ▁important ▁in ▁H . ▁poly gy rus ▁protection