ine , ▁trim eth op rim , ▁and ▁z id ov ud ine ▁are ▁on ▁the ▁World ▁Health ▁Organ ization ' s ▁List ▁of ▁Ess ential ▁Medic ines , ▁the ▁saf est ▁and ▁most ▁effective ▁medic ines ▁needed ▁in ▁a ▁health ▁system . ▁ ▁Mal aria ▁v acc ine ▁In ▁ 2 0 1 4 , ▁G SK ▁applied ▁for ▁regul atory ▁appro val ▁for ▁the ▁first ▁mal aria ▁v acc ine . ▁Mal aria ▁is ▁responsible ▁for ▁over ▁ 6 5 0 , 0 0 0 ▁death s ▁ann ually , ▁mainly ▁in ▁Africa . ▁Kn own ▁as ▁R TS , S , ▁the ▁v acc ine ▁was ▁developed ▁as ▁a ▁joint ▁project ▁with ▁the ▁PATH ▁v acc ines ▁initi ative ▁and ▁the ▁Bill ▁and ▁Mel inda ▁G ates ▁Foundation . ▁The ▁company ▁has ▁committed ▁to ▁making ▁the ▁v acc ine ▁available ▁in ▁developing ▁countries ▁for ▁five ▁percent ▁above ▁the ▁cost ▁of ▁production . ▁ ▁, ▁R TS , S , ▁which ▁uses ▁G SK ' s ▁propriet ary ▁AS 0 1 ▁adj uv ant , ▁was ▁being ▁exam ined ▁in ▁a ▁Ph ase ▁ 3 ▁trial ▁in ▁eight ▁African ▁countries . ▁PATH ▁reported ▁that ▁"[ i ] n ▁the ▁ 1 2 - month ▁period ▁following ▁v acc ination , ▁R TS , S ▁con ferred ▁approximately ▁ 5 0 % ▁protection ▁from ▁clin ical ▁Pl as mod ium ▁fal ci par um ▁disease ▁in ▁children ▁aged ▁ 5 - 1 7 ▁months , ▁and ▁approximately ▁ 3 0 % ▁protection