▁automatic ▁comp ound ▁application ▁for ▁ion ▁channel ▁screen ing . ▁The ▁system ▁is ▁accessible ▁for ▁optical ▁or ▁sc anning ▁pro be ▁techniques . ▁Per f usion ▁of ▁the ▁int rac ell ular ▁side ▁can ▁be ▁performed . ▁ ▁Other ▁methods ▁ ▁Sol id - supported ▁memb rane ▁( SS M )- based ▁With ▁this ▁electro phys i ological ▁approach , ▁prote ol ip os om es , ▁memb rane ▁ves icles , ▁or ▁memb rane ▁fragments ▁containing ▁the ▁channel ▁or ▁trans porter ▁of ▁interest ▁are ▁ad s or bed ▁to ▁a ▁li pid ▁mon ol ayer ▁painted ▁over ▁a ▁functional ized ▁electro de . ▁This ▁electro de ▁consists ▁of ▁a ▁glass ▁support , ▁a ▁chrom ium ▁layer , ▁a ▁gold ▁layer , ▁and ▁an ▁oct ade cy l ▁mer capt ane ▁mon ol ayer . ▁Because ▁the ▁painted ▁memb rane ▁is ▁supported ▁by ▁the ▁electro de , ▁it ▁is ▁called ▁a ▁solid - supported ▁memb rane . ▁It ▁is ▁important ▁to ▁note ▁that ▁mechanical ▁perturb ations , ▁which ▁usually ▁destroy ▁a ▁bi ological ▁li pid ▁memb rane , ▁do ▁not ▁influence ▁the ▁life - time ▁of ▁an ▁SS M . ▁The ▁capac itive ▁electro de ▁( com posed ▁of ▁the ▁SS M ▁and ▁the ▁absor bed ▁ves icles ) ▁is ▁so ▁mechan ically ▁stable ▁that ▁solutions ▁may ▁be ▁rapidly ▁ex changed ▁at ▁its ▁surface . ▁This ▁property ▁allows ▁the ▁application ▁of ▁rapid ▁substr ate / lig and ▁concentration ▁j umps ▁to ▁investigate ▁the ▁electro gen ic ▁activity ▁of ▁the ▁protein ▁of ▁interest ,