▁the ▁central ▁nerv ous ▁system . ▁It ▁has ▁been ▁shown ▁in ▁phase ▁III ▁clin ical ▁tri als ▁to ▁reduce ▁rela ps es ▁and ▁improve ▁other ▁out comes ▁in ▁multiple ▁s cl eros is . ▁ ▁S 1 P , ▁as ▁well ▁as ▁F TY 7 2 0 , ▁has ▁been ▁shown ▁to ▁have ▁anti - infl am mat ory ▁properties ▁at ▁low ▁concentr ations ▁and ▁prevent ▁mon ocy te : end oth el ial ▁interactions ▁in ▁a ort a , ▁possibly ▁through ▁the ▁S 1 P 1 ▁re ceptor . ▁ ▁O NO - 4 6 4 1 ▁( a ▁drug ▁of ▁O no ▁Ph arma ce ut ical ▁Co ., ▁Ltd .) ▁is ▁a ▁s ph ing os ine - 1 - ph osph ate ▁( S 1 P ) ▁re ceptor ▁ag on ist ▁which ▁keeps ▁l ym ph ocy tes ▁in ▁l ym ph ▁nodes ▁and ▁thereby ▁in hib its ▁the ▁in fil tr ation ▁of ▁l ym ph ocy tes ▁into ▁les ions . ▁The ▁comp ound ▁is ▁therefore ▁expected ▁to ▁be ▁a ▁drug ▁for ▁the ▁treatment ▁of ▁auto - imm une ▁dise ases ▁such ▁as ▁multiple ▁s cl eros is , ▁which ▁is ▁regarded ▁as ▁an ▁int ract able ▁disease . ▁ ▁O z anim od ▁is ▁an ▁ag on ist ▁of ▁the ▁S 1 P 1 ▁and ▁S 1 P 5 ▁re cept ors . ▁and ▁has ▁been ▁studied ▁for ▁various ▁forms ▁of ▁multiple ▁s cl eros is . ▁ ▁See ▁also ▁ ▁S ph ing os