the - cur ve ▁levels ▁by ▁ 1 . 6 - ▁and ▁ 2 . 5 - fold ▁in ▁the ▁fast ed ▁and ▁fed ▁states , ▁respectively . ▁Similar ▁find ings ▁were ▁observed ▁for ▁chron ic ▁administration . ▁In take ▁of ▁dan az ol ▁with ▁food ▁( > 3 0 ▁gr ams ▁of ▁fat ) ▁has ▁been ▁found ▁to ▁increase ▁the ▁bio av ail ability ▁and ▁peak ▁levels ▁of ▁dan az ol ▁by ▁ 3 - ▁to ▁ 4 - fold ▁with ▁a ▁single ▁do se ▁and ▁by ▁ 2 - ▁to ▁ 2 . 5 - fold ▁with ▁chron ic ▁administration . ▁Following ▁administration ▁of ▁dan az ol , ▁peak ▁concentr ations ▁occur ▁after ▁ 2 ▁to ▁ 8   h ours , ▁with ▁a ▁median ▁of ▁ 4   h ours . ▁Ste ady - state ▁levels ▁of ▁dan az ol ▁are ▁achieved ▁after ▁ 6   days ▁of ▁twice - d aily ▁administration . ▁Dan az ol ▁is ▁lip oph il ic ▁and ▁can ▁partition ▁into ▁cell ▁memb ran es , ▁which ▁indicates ▁that ▁it ▁is ▁likely ▁to ▁dist ribute ▁deeply ▁into ▁t issue ▁compart ments . ▁The ▁volume ▁of ▁distribution ▁of ▁dan az ol ▁is ▁ 3 . 4   L . ▁Dan az ol ▁is ▁known ▁to ▁be ▁pl asma ▁protein ▁bound ▁to ▁album in , ▁SH B G , ▁and ▁C B G . ▁ ▁Dan az ol ▁is ▁met abol ized ▁in ▁the ▁li ver ▁by ▁en zym es ▁such ▁as ▁C Y P 3 A