▁p yl ori ▁in fection ▁and ▁functional ▁d ys pe ps ia , ▁others ▁have ▁not . ▁The ▁dis cre p ancy ▁may ▁stem ▁in ▁part ▁from ▁differences ▁in ▁method ology ▁and ▁lack ▁of ▁ade qu ate ▁consideration ▁of ▁conf ounding ▁factors ▁such ▁as ▁past ▁history ▁of ▁pe ptic ▁ul cer ▁disease ▁and ▁so cio e conom ic ▁status . ▁Control led ▁tri als ▁disag ree ▁about ▁whether ▁or ▁not ▁H . ▁p yl ori ▁er adic ation ▁is ▁benef icial ▁in ▁functional ▁d ys pe ps ia , ▁with ▁roughly ▁half ▁of ▁the ▁tri als ▁showing ▁improvement ▁and ▁the ▁other ▁half ▁no ▁improvement . ▁In ▁a ▁recent ▁mult ic enter ▁U . S . ▁trial ▁that ▁random ized ▁ 2 4 0 ▁patients ▁to ▁treatment ▁or ▁place bo , ▁and ▁followed ▁patients ▁for ▁ 1 2 ▁months , ▁ 2 8 % ▁of ▁treated ▁patients ▁versus ▁ 2 3 % ▁of ▁those ▁receiving ▁place bo ▁reported ▁relief ▁of ▁sympt oms ▁at ▁the ▁ 1 2 - month ▁follow - up . ▁Similarly , ▁recent ▁European ▁tri als ▁have ▁not ▁shown ▁significant ▁differences ▁in ▁sympt oms ▁after ▁H . ▁p yl ori ▁er adic ation ▁as ▁compared ▁with ▁controls . ▁System atic ▁reviews ▁of ▁er adic ation ▁have ▁been ▁conducted , ▁with ▁varying ▁results . ▁A ▁system atic ▁review ▁in ▁the ▁Ann als ▁of ▁In ternal ▁Medicine ▁suggested ▁no ▁statist ically ▁significant ▁effect , ▁with ▁an ▁odd s ▁ratio ▁( OR ) ▁for ▁treatment ▁success ▁versus ▁control ▁of ▁ 1 . 2 9