▁to ▁nearby ▁cells ▁and ▁the ▁cell ▁it ▁origin ated ▁from ▁via ▁a ▁transm emb rane ▁protein , ▁o lig ope pt ide ▁per me ase . ▁In ▁the ▁c yt os ol ▁the ▁ph er om ones ▁have ▁two ▁functions ▁in ▁the ▁R gg 2 / 3 ▁path way . ▁First ly , ▁they ▁in hib it ▁the ▁activity ▁of ▁R gg 3 ▁which ▁is ▁a ▁trans cription al ▁reg ulator ▁repr ess ing ▁S HP ▁production . ▁Second ly , ▁they ▁bind ▁another ▁trans cription al ▁reg ulator , ▁R gg 2 , ▁that ▁increases ▁the ▁production ▁of ▁S HP ' s , ▁having ▁an ▁ant agon istic ▁effect ▁to ▁R gg 3 . ▁S HP ' s ▁activ ating ▁their ▁own ▁trans cription al ▁activ ator ▁creates ▁a ▁positive ▁feedback ▁loop , ▁which ▁is ▁common ▁for ▁the ▁production ▁for ▁qu orum ▁sens ing ▁pe pt ides . ▁It ▁enables ▁the ▁rapid ▁production ▁of ▁the ▁ph er om ones ▁in ▁large ▁quantities . ▁The ▁production ▁of ▁S HP ' s ▁increases ▁bio film ▁bi ogen esis . ▁It ▁has ▁been ▁suggested ▁that ▁G AS ▁switch es ▁between ▁bio film ▁formation ▁and ▁de grad ation ▁by ▁util izing ▁to ▁path ways ▁with ▁oppos ing ▁effects . ▁Wh ilst ▁R gg 2 / 3 ▁path way ▁increases ▁bio film , ▁the ▁R op B ▁path way ▁dis rupt s ▁it . ▁R op B ▁is ▁another ▁R gg - like ▁protein ▁( R gg 1 ) ▁that ▁directly ▁activ ates ▁Spe B ▁( St