. ▁ ▁However , ▁despite ▁this ▁impress ive ▁imm une ▁response , ▁H . ▁poly gy rus ▁is ▁able ▁to ▁hij ack ▁the ▁host ▁imm une ▁response , ▁d amp ening ▁the ▁Th 2 ▁response ▁generated ▁against ▁itself , ▁resulting ▁in ▁chron ic ▁in fection . ▁This ▁imm une ▁reg ulation ▁occurs ▁through ▁a ▁strong ▁regul atory ▁T ▁cell ▁response ▁el ic ited ▁in ▁the ▁s ple en ▁and ▁the ▁m esent er ic ▁l ym ph ▁nodes ▁of ▁the ▁host , ▁mainly ▁involving ▁CD 2 5 + CD 1 0 3 + ▁regul atory ▁T ▁cells . ▁Another ▁factor ▁might ▁be ▁the ▁production ▁of ▁H . ▁poly gy rus ▁al ar min ▁release ▁in hib itor ▁( ), ▁an ▁IL - 3 3 - supp ress ive ▁ 2 6 - k Da ▁S ush i ▁domain ▁protein , ▁in hib iting ▁processing ▁of ▁IL 3 3 ▁into ▁its ▁active ▁form . ▁ ▁Pre vention ▁and ▁treatment ▁ ▁No ▁formal ▁prevent ion ▁strateg ies ▁exist ▁for ▁control ▁of ▁H . ▁poly gy rus , ▁although ▁the ▁par as ite ▁is ▁sus cept ible ▁to ▁a ▁number ▁of ▁drug ▁treat ments . ▁Tre at ment ▁of ▁an ▁inf ected ▁mouse ▁with ▁p yr ant el ▁p amo ate , ▁i ver m ect in , ▁or ▁other ▁anth elm int ic ▁dru gs ▁helps ▁clear ▁in fection ▁and ▁provides ▁imm unity ▁to ▁rein fection . ▁Furthermore , ▁a ▁co ck tail ▁of ▁H . ▁poly gy rus ▁ex cret ory - secret ory