▁the ▁flow ▁of ▁mac rom ole cules ▁between ▁the ▁nucle us ▁and ▁the ▁cy top las m . ▁N uc le op or ins ▁are ▁the ▁main ▁components ▁of ▁the ▁nuclear ▁p ore ▁complex ▁in ▁e uk ary otic ▁cells . ▁The ▁protein ▁encoded ▁by ▁this ▁gene ▁is ▁a ▁member ▁of ▁the ▁F G - repeat ▁containing ▁nucle op or ins ▁and ▁is ▁local ized ▁to ▁the ▁nuclear ▁p ore ▁central ▁plug . ▁This ▁protein ▁associ ates ▁with ▁the ▁import in ▁alpha / beta ▁complex ▁which ▁is ▁involved ▁in ▁the ▁import ▁of ▁prote ins ▁containing ▁nuclear ▁local ization ▁signals . ▁Multiple ▁trans cript ▁variants ▁of ▁this ▁gene ▁encode ▁a ▁single ▁protein ▁is o form . ▁ ▁Str ucture ▁ ▁P 6 2 ▁is ▁a ▁ser ine / th re on ine ▁rich ▁protein ▁of ▁~ 5 2 0 ▁am ino ▁ac ids , ▁with ▁t etra pe pt ide ▁repe ats ▁on ▁the ▁am ino ▁termin us ▁and ▁a ▁series ▁of ▁alpha - hel ical ▁regions ▁with ▁hydro ph ob ic ▁he pt ad ▁repe ats ▁forming ▁beta - prop eller ▁domain . ▁P 6 2 ▁assemb les ▁into ▁a ▁complex ▁containing ▁ 3 ▁addition ▁prote ins , ▁p 6 0 , ▁p 5 4 ▁and ▁p 4 5 ▁ ▁forming ▁the ▁p 6 2 ▁complex ▁of ▁~ 2 3 5 ▁k Da . ▁G ly cos yl ation ▁appears ▁to ▁be ▁involved ▁in ▁the ▁assembly ▁and ▁dis assembly ▁of ▁p 6 2 ▁into ▁higher ▁order ▁complex es , ▁and ▁a ▁ser ine