1 1 ▁and ▁AB CC 8 , ▁which ▁is ▁a ▁result ▁of ▁ 3 1 % ▁and ▁ 1 0 % ▁of ▁P ND M ▁cases ▁( results ▁based ▁on ▁Ex eter ▁experiment ▁series ). ▁Tw elve ▁percent ▁of ▁mut ations ▁in ▁the ▁ins ul in ▁gene ▁leads ▁to ▁P ND M . ▁ ▁K CN J 1 1 ▁and ▁AB CC 8 ▁Gen es ▁association ▁with ▁B eta - cell ▁ATP ▁S ens itive ▁Pot ass ium ▁Channel ▁ ▁K CN J 1 1 ▁enc odes ▁Kir 6 . 2 ▁( a ▁protein ▁coding ▁gene ▁in ▁the ▁pot ass ium ▁channel ) ▁and ▁AB CC 8 ▁enc odes ▁the ▁gene , ▁S UR 1 ▁( the ▁type ▁ 1 ▁sub unit ▁of ▁the ▁sul fony l ure a ▁re ceptor ), ▁a ▁member ▁of ▁the ▁ATP - binding ▁c ass ette ▁trans porter ▁family , ▁the ▁two ▁ ▁components ▁of ▁the ▁K AT P ▁channel . ▁This ▁channel ▁links ▁gl uc ose ▁met abol ism ▁to ▁ins ul in ▁secret ion ▁by ▁closing ▁in ▁response ▁to ▁ATP . ▁Blood ▁gl uc ose ▁storage ▁into ▁B eta - cell s ▁lead ▁to ▁g ly col ysis ▁and ▁cause ▁ATP ▁generation . ▁The ▁elev ated ▁ATP / aden os ine ▁di ph osph ate ▁ratio ▁causes ▁closure ▁of ▁the ▁ ▁K AT P ▁channel , ▁and ▁in hib it ▁pot ass ium ▁eff l ux ▁( a ▁lot ▁of ▁pot ass ium ▁flows ▁out ▁of ▁this ▁channel ), ▁that ▁leads ▁to ▁dep olar ization