▁rural ▁local ity . ▁ ▁References ▁▁ ▁Category : R ural ▁local ities ▁in ▁V olog da ▁O blast ▁Category : R ural ▁local ities ▁in ▁V olog od sky ▁District <0x0A> </s> ▁Im m une ▁Select ive ▁Anti - Infl am mat ory ▁Der iv atives ▁( Im SA ID s ) ▁are ▁a ▁class ▁of ▁pe pt ides ▁that ▁have ▁anti - infl am mat ory ▁properties . ▁ ▁Im SA ID s ▁work ▁by ▁alter ing ▁the ▁activation ▁and ▁migration ▁of ▁infl am mat ory ▁cells , ▁which ▁are ▁imm une ▁cells ▁responsible ▁for ▁ampl ifying ▁the ▁infl am mat ory ▁response . ▁ ▁History ▁The ▁Im SA ID s ▁represent ▁a ▁new ▁category ▁of ▁anti - infl am mat ory ▁and ▁are ▁un related ▁to ▁ster oid ▁h orm ones ▁or ▁non ▁ster oid al ▁anti - infl amm ator ies . ▁ ▁The ▁Im SA ID s ▁were ▁discovered ▁by ▁scient ists ▁evalu ating ▁bi ological ▁properties ▁of ▁the ▁subm and ib ular ▁g land ▁and ▁sal iva . ▁ ▁Early ▁work ▁in ▁this ▁area ▁demonstrated ▁that ▁the ▁subm and ib ular ▁g land ▁released ▁a ▁host ▁of ▁factors ▁which ▁reg ulate ▁system ic ▁infl am mat ory ▁responses ▁and ▁mod ulate ▁system ic ▁imm une ▁and ▁infl am mat ory ▁re actions . ▁ ▁Early ▁work ▁in ▁ident ifying ▁factors ▁that ▁played ▁a ▁role ▁in ▁the ▁C ST - SM G ▁axis ▁lead ▁to ▁the ▁discovery ▁of ▁a ▁seven ▁am ino ▁acid ▁pe pt ide , ▁called