ive ▁ther ap ies , ▁many ▁individuals ▁can ▁achieve ▁much ▁more ▁than ▁initially ▁thought . ▁It ▁has ▁become ▁clearer ▁that ▁there ▁is ▁a ▁wider ▁range ▁of ▁cogn itive ▁ab ilities ▁in ▁Pitt – H op kins ▁than ▁reported ▁in ▁much ▁of ▁the ▁scientific ▁literature . ▁Research ers ▁have ▁developed ▁cell ▁and ▁rod ent ▁models ▁to ▁test ▁ther ap ies ▁for ▁Pitt – H op kins . ▁ ▁Sign s ▁and ▁sympt oms ▁ ▁P TH S ▁can ▁be ▁seen ▁as ▁early ▁as ▁child hood . ▁ ▁The ▁earliest ▁signs ▁in ▁inf ants ▁is ▁the ▁lower ▁face ▁and ▁the ▁high ▁nas al ▁root . ▁ ▁The ▁fa cial ▁features ▁are ▁characteristic ▁and ▁include : ▁ ▁Deep ▁set ▁eyes ▁St rab ismus ▁My op ia ▁Mark ed ▁nas al ▁root ▁Broad ▁and / or ▁be aked ▁nas al ▁bridge ▁Prom inent ▁Cup id ' s ▁bow ▁or ▁tent ed ▁upper ▁lip ▁( upper ▁lip ▁with ▁the ▁appearance ▁of ▁a ▁tent ) ▁E vert ed ▁lower ▁lip ▁Lar ge ▁mouth ▁W id ely ▁spac ed ▁teeth ▁W ide ▁and ▁shall ow ▁pal ate ▁E ars ▁with ▁a ▁thick ▁and ▁over fold ed ▁hel ix ▁( the ▁outer most ▁fol d ▁of ▁the ▁ear ) ▁ ▁Ad ult s ▁who ▁have ▁P TH S ▁may ▁have ▁trouble ▁with ▁their ▁speech . ▁C ran io fa cial ▁features , ▁which ▁are ▁important ▁when ▁diagn osing ▁P TH S , ▁become ▁more ▁visible ▁as ▁the ▁person ▁gets ▁older . ▁ ▁P TH S ▁is ▁character ized ▁by ▁development al