▁reaction ▁test ▁( which ▁came ▁to ▁be ▁known ▁as ▁the ▁" M ol oney ▁Test ") ▁to ▁test ▁for ▁potential ▁react ors ▁to ▁avoid ▁the ▁issue . ▁ ▁The ▁results ▁of ▁to x oid ▁use ▁in ▁Hamilton , ▁Ontario ▁were ▁particularly ▁significant ▁and ▁widely ▁recognized . ▁In ▁ 1 9 2 2 , ▁there ▁were ▁ 7 4 7 ▁cases ▁and ▁ 3 2 ▁death s ▁due ▁to ▁di ph ther ia ▁in ▁Hamilton . ▁By ▁ 1 9 2 7 , ▁the ▁numbers ▁had ▁fallen ▁to ▁ 1 1 ▁cases ▁and ▁ 1 ▁death . ▁In ▁ 1 9 3 1 , ▁there ▁were ▁only ▁ 5 ▁cases ▁and ▁no ▁death s . ▁A ▁year ▁later , ▁there ▁was ▁a ▁single ▁case ▁and ▁no ▁death s . ▁ ▁Development ▁of ▁he par in : ▁ 1 9 2 8 - 1 9 3 0 s ▁ ▁He par in ▁is ▁a ▁blood ▁th inner ▁( ant ico ag ul ant ), ▁originally ▁discovered ▁in ▁ 1 9 1 6 ▁by ▁Jay ▁Mc Le an ▁and ▁William ▁Henry ▁How ell ▁at ▁Joh ns ▁Hop kins ▁University . ▁However , ▁the ▁cru de ▁subst ance ▁was ▁to xic ▁and ▁could ▁only ▁be ▁extracted ▁in ▁small ▁quantities . ▁As ▁co - dis cover er ▁of ▁ins ul in ▁Charles ▁Best ▁returned ▁from ▁his ▁post grad uate ▁studies ▁in ▁Europe ▁to ▁continue ▁as ▁Con n aught ' s ▁Ass istant ▁Director , ▁he ▁began ▁a ▁program ▁in ▁ 1 9 2 8 ▁to ▁pur ify ▁he