ual ▁disease ▁as ▁a ▁new ▁approach ▁for ▁potential ▁c ure ▁of ▁cancer ▁at ▁an ▁early ▁stage ▁of ▁the ▁disease . ▁ ▁Int rodu cing ▁N ST ▁and ▁R IC ▁made ▁it ▁possible ▁to ▁provide ▁cur ative ▁stem ▁cell ▁trans plant ation ▁for ▁a ▁large ▁number ▁of ▁patients ▁in ▁need ▁with ▁no ▁lower ▁or ▁upper ▁age ▁group ▁including ▁patient ' s ▁in ▁poor ▁performance ▁status ▁but ▁would ▁not ▁be ▁otherwise ▁candidates ▁for ▁conventional ▁my elo abl ative ▁al log ene ic ▁stem ▁cell ▁trans plant ation . ▁Using ▁N ST ▁and ▁R IC ▁provided ▁a ▁safe ▁approach ▁for ▁trans plant ation ▁of ▁patient ' s ▁particularly ▁sensitive ▁to ▁conventional ▁c yt ored uct ive ▁condition ing ▁including ▁older ▁patients , ▁patients ▁with ▁F an con i ' s ▁an emia ▁and ▁chron ic ▁gran ul om at ous ▁disease . ▁ ▁Later ▁on , ▁introdu cing ▁the ▁concept ▁of ▁post - trans plant ▁delet ion ▁of ▁all ore active ▁l ym ph ocy tes ▁by ▁cy clo ph osph am ide ▁by ▁S la vin ' s ▁team ▁made ▁it ▁possible ▁to ▁provide ▁a ▁relatively ▁safe ▁and ▁non - exp ensive ▁trans plant ▁procedure ▁for ▁patients ▁with ▁no ▁matched ▁don or ▁available ▁using ▁ha p lo ident ical ▁family ▁member . ▁ ▁The ▁same ▁principle ▁was ▁applied ▁by ▁S la vin ▁for ▁successful ▁induction ▁of ▁trans plant ation ▁toler ance ▁to ▁organ ▁al log raft s ▁pione ered ▁successfully ▁for ▁the ▁first ▁recip ient ▁of ▁kid ney ▁al log raft ▁alive ▁and ▁well ▁>