▁a ▁way ▁that ▁requires ▁significantly ▁less ▁time ▁and ▁money . ▁ ▁Ros etta @ home ▁also ▁develop s ▁methods ▁to ▁determine ▁the ▁structure ▁and ▁dock ing ▁of ▁memb rane ▁prote ins ▁( e . g ., ▁G ▁protein – cou ple d ▁re cept ors ▁( G PC R s )), ▁which ▁are ▁exception ally ▁difficult ▁to ▁analyze ▁with ▁traditional ▁techniques ▁like ▁X - ray ▁cry stal log raph y ▁and ▁N MR ▁spect ro sc opy , ▁yet ▁represent ▁the ▁majority ▁of ▁targets ▁for ▁modern ▁dru gs . ▁ ▁Progress ▁in ▁protein ▁structure ▁prediction ▁is ▁evaluated ▁in ▁the ▁b ian n ual ▁Crit ical ▁Ass ess ment ▁of ▁Te chni ques ▁for ▁Prote in ▁Str ucture ▁Pred iction ▁( C AS P ) ▁experiment , ▁in ▁which ▁research ers ▁from ▁around ▁the ▁world ▁attempt ▁to ▁derive ▁a ▁protein ' s ▁structure ▁from ▁the ▁protein ' s ▁am ino ▁acid ▁sequence . ▁ ▁High ▁scoring ▁groups ▁in ▁this ▁sometimes ▁compet itive ▁experiment ▁are ▁considered ▁the ▁de ▁fact o ▁standard - b ear ers ▁for ▁what ▁is ▁the ▁state ▁of ▁the ▁art ▁in ▁protein ▁structure ▁prediction . ▁ ▁Ros etta , ▁the ▁program ▁on ▁which ▁Ros etta @ home ▁is ▁based , ▁has ▁been ▁used ▁since ▁C AS P 5 ▁in ▁ 2 0 0 2 . ▁ ▁In ▁the ▁ 2 0 0 4 ▁C AS P 6 ▁experiment , ▁Ros etta ▁made ▁history ▁by ▁being ▁the ▁first ▁to ▁produce ▁a ▁close ▁to ▁atomic - level ▁resolution , ▁ab ▁init io ▁protein ▁structure