▁transmission , ▁leading ▁to ▁to x icity , ▁known ▁as ▁b rom ism . ▁B rom ide ▁has ▁an ▁elim ination ▁half - life ▁of ▁ 9 ▁to ▁ 1 2 ▁days , ▁which ▁can ▁lead ▁to ▁excess ive ▁accum ulation . ▁D oses ▁of ▁ 0 . 5 ▁to ▁ 1   gram ▁per ▁day ▁of ▁b rom ide ▁can ▁lead ▁to ▁b rom ism . ▁Histor ically , ▁the ▁th era pe ut ic ▁do se ▁of ▁b rom ide ▁is ▁about ▁ 3 ▁to ▁ 5   gram s ▁of ▁b rom ide , ▁thus ▁explaining ▁why ▁chron ic ▁to x icity ▁( b rom ism ) ▁was ▁once ▁so ▁common . ▁While ▁significant ▁and ▁sometimes ▁serious ▁dist urban ces ▁occur ▁to ▁ne uro logic , ▁psych iat ric , ▁der mat ological , ▁and ▁g astro int est inal ▁functions , ▁death ▁from ▁b rom ism ▁is ▁rare . ▁B rom ism ▁is ▁caused ▁by ▁a ▁ne uro to xic ▁effect ▁on ▁the ▁brain ▁which ▁results ▁in ▁som n ol ence , ▁psych osis , ▁se iz ures ▁and ▁del iri um . ▁ ▁Element al ▁b rom ine ▁is ▁to xic ▁and ▁causes ▁chemical ▁burn s ▁on ▁human ▁flesh . ▁In hal ing ▁b rom ine ▁gas ▁results ▁in ▁similar ▁ir rit ation ▁of ▁the ▁resp ir atory ▁tract , ▁causing ▁c ough ing , ▁ch oking , ▁and ▁short ness ▁of ▁breath , ▁and ▁death ▁if ▁in h aled ▁in ▁large ▁enough ▁amounts . ▁Chron ic ▁expos