itis ▁and / or ▁ul cer ations ▁and ▁per for ations ▁of ▁the ▁g astro int est inal ▁tract , ▁but ▁occasionally ▁due ▁to ▁a calcul ous ▁ch ole c yst itis ▁or ▁gran ul om at ous ▁append ic itis . ▁ ▁The ▁most ▁serious ▁comp lication ▁of ▁the ▁vas cul it ic ▁stage ▁is ▁heart ▁disease , ▁which ▁is ▁the ▁cause ▁of ▁nearly ▁one - half ▁of ▁all ▁death s ▁in ▁patients ▁with ▁E G PA . ▁Among ▁heart ▁disease - related ▁death s , ▁the ▁most ▁usual ▁cause ▁is ▁infl amm ation ▁of ▁the ▁heart ▁mus cle ▁caused ▁by ▁the ▁high ▁level ▁of ▁e os in oph ils , ▁although ▁some ▁are ▁death s ▁due ▁to ▁infl amm ation ▁of ▁the ▁ar ter ies ▁that ▁supply ▁blood ▁to ▁the ▁heart ▁or ▁per ic ard ial ▁tam pon ade . ▁Kid ney ▁comp lications ▁have ▁been ▁reported ▁as ▁being ▁less ▁common . ▁ ▁Di agn osis ▁ ▁Di agnostic ▁markers ▁include ▁e os in oph il ▁gran ul ocy tes ▁and ▁gran ul omas ▁in ▁affected ▁t issue , ▁and ▁ant ine ut roph il ▁cy top las mic ▁ant ib od ies ▁( AN CA ) ▁against ▁neut roph il ▁gran ul ocy tes . ▁ ▁The ▁American ▁College ▁of ▁R he um at ology ▁ 1 9 9 0 ▁criteria ▁for ▁diagn osis ▁of ▁Ch urg – St ra uss ▁synd rome ▁lists ▁these ▁criteria : ▁Ast h ma ▁E os in oph ilia , ▁i . e .