▁are , ▁however , ▁reasons ▁to ▁differenti ate ▁between ▁the ▁two ▁dise ases . ▁As ▁mentioned ▁earlier , ▁both ▁dise ases ▁affect ▁dia ph ysis , ▁but ▁Gh os al ▁h emat odia phy se al ▁d ys pl asia , ▁affect s ▁both ▁the ▁dia ph ysis , ▁and ▁met aph ys es . ▁Also , ▁Cam ur ati - Eng el man ▁disease ▁has ▁no ▁sign ▁of ▁defect ive ▁h emat opo ies is , ▁but ▁Gh os al ▁h emat odia phy se al ▁d ys pl asia ▁is ▁associated ▁with ▁a ▁h emat ological ▁ab normal ity . ▁ ▁This ▁is ▁a ▁rare ▁disease ▁and ▁was ▁character ized ▁in ▁ 1 9 8 8 ▁by ▁Gh os al ▁in ▁several ▁children ▁with ▁an emia ▁and ▁b ony ▁d ys pl asia . ▁Later , ▁in ▁ 2 0 0 8 , ▁there ▁was ▁a ▁discovery ▁that ▁a ▁mut ation ▁in ▁the ▁gene ▁T B X AS 1 ▁cause ▁some ▁of ▁the ▁distinct ▁features ▁in ▁this ▁disease ▁such ▁as ▁increased ▁b one ▁density . ▁ ▁Most ▁cases ▁are ▁found ▁in ▁India ▁and ▁the ▁Middle ▁East ▁area , ▁likely ▁meaning ▁a ▁shared ▁gene ▁pool . ▁ ▁History ▁ ▁There ▁were ▁five ▁patients ▁in ▁early ▁child hood ▁had ▁two ▁significant ▁sympt oms ▁of ▁the ▁disease ▁character ized ▁today ▁as ▁Gh os al ▁h emat odia phy se al ▁d ys pl asia . ▁The ▁two ▁sympt oms ▁described ▁were ▁thick ▁long ▁b ones ▁of ▁the ▁extrem ities ▁with ▁features ▁of ▁dia phy