. ▁ ▁Ros etta ▁is ▁used ▁in ▁the ▁Crit ical ▁Ass ess ment ▁of ▁Pred iction ▁of ▁Inter actions ▁( C AP RI ) ▁experiment , ▁which ▁evalu ates ▁the ▁state ▁of ▁the ▁protein ▁dock ing ▁field ▁similar ▁to ▁how ▁C AS P ▁gau ges ▁progress ▁in ▁protein ▁structure ▁prediction . ▁ ▁The ▁computing ▁power ▁made ▁available ▁by ▁Ros etta @ home ' s ▁project ▁volunte ers ▁has ▁been ▁c ited ▁as ▁a ▁major ▁factor ▁in ▁Ros etta ' s ▁performance ▁in ▁C AP RI , ▁where ▁its ▁dock ing ▁predictions ▁have ▁been ▁among ▁the ▁most ▁accurate ▁and ▁complete . ▁ ▁In ▁early ▁ 2 0 0 8 , ▁Ros etta ▁was ▁used ▁to ▁computation ally ▁design ▁a ▁protein ▁with ▁a ▁function ▁never ▁before ▁observed ▁in ▁nature . ▁This ▁was ▁inspired ▁in ▁part ▁by ▁the ▁retra ction ▁of ▁a ▁high - profile ▁paper ▁from ▁ 2 0 0 4 ▁which ▁originally ▁described ▁the ▁computational ▁design ▁of ▁a ▁protein ▁with ▁improved ▁en zym atic ▁activity ▁relative ▁to ▁its ▁natural ▁form . ▁The ▁ 2 0 0 8 ▁research ▁paper ▁from ▁David ▁Baker ' s ▁group ▁describing ▁how ▁the ▁protein ▁was ▁made , ▁which ▁c ited ▁Ros etta @ home ▁for ▁the ▁computing ▁resources ▁it ▁made ▁available , ▁represented ▁an ▁important ▁proof ▁of ▁concept ▁for ▁this ▁protein ▁design ▁method . ▁This ▁type ▁of ▁protein ▁design ▁could ▁have ▁future ▁applications ▁in ▁drug ▁discovery , ▁green ▁chem istry , ▁and ▁b ior emed iation . ▁ ▁D ise ase - related ▁research ▁▁ ▁In ▁addition ▁to ▁basic