▁first ▁episode ▁was ▁released ▁on ▁i T unes ▁on ▁March ▁ 1 3 , ▁ 2 0 0 5 , ▁with ▁each ▁episode ▁being ▁approximately ▁ 5 ▁minutes ▁in ▁length . ▁The ▁show ▁origin ated ▁from ▁V ancouver , ▁British ▁Columbia ▁and ▁has ▁not ▁been ▁updated ▁since ▁E pisode ▁ 4 5 ▁( Dec ember ▁ 1 2 , ▁ 2 0 0 9 ). ▁It ▁was ▁produced ▁by ▁T os ca ▁Mus k ▁and ▁is ▁considered ▁by ▁many ▁to ▁be ▁one ▁of ▁the ▁pione ering ▁video ▁pod cast s ▁cred ited ▁with ▁launch ing ▁the ▁genre . ▁ ▁Char acters ▁Doctor ▁T iki , ▁Ph D , ▁MD , ▁USB ▁a . k . a . ▁Regin ald ▁Horn stein ▁( J eff ▁Mac ph erson ) ▁writes ▁the ▁co ck tail ▁pres cri ptions ▁in ▁each ▁episode . ▁His ▁doctor ate ▁is ▁in ▁" T iki ," ▁and ▁he ▁is ▁usually ▁we aring ▁a ▁lab ▁coat ▁and ▁st eth os cope . ▁Johnny ▁Johnny , ▁Mix ologist ▁a . k . a . ▁Jonathan ▁J . ▁Jonathan ▁( Ke vin ▁Gam ble ) ▁is ▁the ▁le op ard - print ▁fe z ▁we aring ▁b art ender ▁who ▁makes ▁the ▁co ck t ails ▁that ▁the ▁Doctor ▁pres cri bes . ▁L ala ▁a . k . a . ▁Be atrice ▁Fast water ▁( L ara ▁Dou c ette ). ▁She ▁usually ▁we ars ▁a ▁provoc ative ▁dress ▁and ▁broad ▁gr in . ▁In ▁episode ▁ 1 0 , ▁we ▁learn