rel ▁surrounding ▁a ▁central ▁alpha ▁hel ix . ▁T ub by ▁prote ins ▁can ▁bind ▁the ▁small ▁cell ▁signal ing ▁mole c ule ▁ph osph at id y lin os it ol , ▁which ▁is ▁typically ▁local ized ▁to ▁the ▁cell ▁memb rane . ▁A ▁similar ▁struct ural ▁fol d ▁to ▁the ▁T ub by ▁like ▁prote ins ▁has ▁been ▁identified ▁in ▁the ▁Sc r amb l ase ▁family ▁of ▁prote ins . ▁ ▁Function ▁T ub by ▁prote ins ▁have ▁been ▁imp licated ▁as ▁trans cription ▁factors ▁and ▁as ▁potential ▁signal ing ▁factors ▁couple d ▁to ▁G - prote in ▁activity . ▁They ▁are ▁associated ▁with ▁neur onal ▁different iation ▁and ▁development , ▁and ▁in ▁m amm als ▁are ▁imp licated ▁in ▁three ▁disease ▁processes ▁when ▁mut ated : ▁ob es ity , ▁ret inal ▁deg ener ation , ▁and ▁hearing ▁loss . ▁In ▁m ice , ▁mut ations ▁in ▁tub by ▁prote ins ▁are ▁known ▁to ▁affect ▁life ▁span ▁and ▁fat ▁storage ▁as ▁well ▁as ▁car bo h yd rate ▁met abol ism . ▁T ub by ▁domains ▁associate ▁with ▁cy top las mic ▁side ▁of ▁cell ▁memb ran es ▁through ▁binding ▁of ▁different ▁ph osph o inos it ides ▁ ▁Human ▁prote ins ▁containing ▁this ▁domain ▁T UB ; ▁▁▁▁▁▁ ▁T U LP 1 ; ▁▁▁▁ ▁T U LP 2 ; ▁▁▁▁ ▁T U LP 3 ; ▁▁▁▁ ▁T U LP 4 ; ▁ ▁External ▁links ▁ ▁S CO P ▁tub by ▁fol d ▁ ▁References ▁ ▁Category : Pro