▁figure ▁ 2 c , ▁where by ▁editing ▁and ▁intr ons ▁in ▁the ▁mit och ond r ion ▁come ▁and ▁go ▁during ▁evolution . ▁In ▁this ▁case , ▁the ▁introduction ▁and ▁removal ▁of ▁the ▁intr on , ▁as ▁well ▁as , ▁reverse ▁trans cription ▁occur ▁within ▁mit och ond ria ▁and ▁the ▁final ▁product , ▁the ▁edited ▁intr on less ▁m t D NA , ▁will ▁integrate ▁into ▁n D NA ▁after ▁being ▁transferred ▁into ▁the ▁nucle us . ▁ ▁Insert ion ▁into ▁the ▁nuclear ▁gen ome : After ▁the ▁prepar atory ▁step ▁is ▁over , ▁m t D NA ▁is ▁ready ▁to ▁be ▁inserted ▁into ▁the ▁nuclear ▁gen ome . ▁Based ▁on ▁NUM T ▁integration ▁site ▁and ▁the ▁analyz ed ▁obtained ▁results ▁from ▁b aker ' s ▁ye ast ▁experiment , ▁Bl anch ard ▁and ▁Schmidt ▁hypoth es ized ▁that ▁m t D NA ▁are ▁inserted ▁into ▁the ▁double - str and ed ▁break ▁( D SB ) ▁via ▁non - hom olog ous ▁end ▁joining ▁mach in ery . ▁The ▁hypothesis ▁is ▁found ▁to ▁be ▁widely ▁accepted . ▁ ▁Later ▁anal ys es ▁were ▁consistent ▁with ▁the ▁invol vement ▁of ▁N HE J ▁in ▁NUM T ▁integration ▁in ▁humans . ▁These ▁processes ▁occur ▁in ▁both ▁som atic ▁and ▁ger ml ine ▁cells . ▁In ▁animals ▁and ▁humans , ▁however , ▁the ▁cap ability ▁of ▁D SB ▁repair ▁in ▁ger ml ine ▁cells ▁depends ▁on ▁the ▁o ogen etic ▁and ▁s per mat ogen etic ▁stage , ▁non eth eless , ▁due