▁col lagen ▁I ▁to ▁switch ▁on ▁different ▁pattern ing ▁mechan isms ▁for ▁V EG FC . ▁ ▁Activ ation ▁ ▁Activ ation ▁of ▁M MP - 2 ▁requires ▁prote ol yt ic ▁processing . ▁A ▁complex ▁of ▁memb rane ▁type ▁ 1 ▁M MP ▁( MT 1 - M MP / M MP 1 4 ) ▁and ▁t issue ▁in hib itor ▁of ▁metal lo prote in ase ▁ 2 ▁rec ruits ▁pro - M MP ▁ 2 ▁from ▁the ▁ext rac ell ular ▁milieu ▁to ▁the ▁cell ▁surface . ▁Activ ation ▁then ▁requires ▁an ▁active ▁mole c ule ▁of ▁M T 1 - M MP ▁and ▁auto ▁catal yt ic ▁cle av age . ▁Cl ust ering ▁of ▁integr in ▁ch ains ▁prom otes ▁activation ▁of ▁M MP - 2 . ▁Another ▁factor ▁that ▁will ▁support ▁the ▁activation ▁of ▁M MP - 2 ▁is ▁cell - cell ▁clust ering . ▁A ▁wild - type ▁activ ated ▁le uk ocy te ▁cell ▁ad hes ion ▁mole c ule ▁( AL C AM ) ▁is ▁also ▁required ▁to ▁activ ate ▁M MP - 2 . ▁ ▁C lin ical ▁significance ▁ ▁Mut ations ▁in ▁the ▁M MP 2 ▁gene ▁are ▁associated ▁with ▁T org - Win chester ▁synd rome , ▁mult ic ent ric ▁o ste ol ysis , ▁ar th rit is ▁synd rome , ▁and ▁possibly ▁k el oid s . ▁ ▁Ro le ▁of ▁M MP - 2 ▁in ▁chron ic ▁disease ▁ ▁Activity ▁of ▁M MP - 2 ▁relative ▁to