▁itself ▁at ▁the ▁PR ▁are ▁relatively ▁low , ▁eth ister one , ▁one ▁of ▁the ▁major ▁met abol ites ▁of ▁dan az ol , ▁is ▁described ▁as ▁a ▁weak ▁pro gest ogen ▁( and ▁has ▁been ▁employed ▁clin ically ▁as ▁a ▁pro gest ogen ), ▁and ▁this ▁pres umably ▁serves ▁to ▁increase ▁the ▁in ▁v ivo ▁pro gest ogen ic ▁activity ▁of ▁dan az ol . ▁The ▁activity ▁of ▁dan az ol ▁at ▁the ▁ER ▁is ▁considered ▁to ▁be ▁minimal , ▁although ▁at ▁very ▁high ▁concentr ations ▁the ▁drug ▁can ▁act ▁significantly ▁as ▁an ▁ER ▁ag on ist . ▁Dan az ol ▁is ▁considered ▁to ▁act ▁significantly ▁as ▁an ▁ag on ist ▁of ▁the ▁GR , ▁and , ▁thus , ▁as ▁a ▁gl uc oc ort ico id . ▁In ▁accord ance , ▁it ▁can ▁suppress ▁the ▁imm une ▁system ▁at ▁sufficient ▁dos ages . ▁ ▁In hib ition ▁of ▁ster oid ogen esis ▁en zym es ▁Dan az ol ▁has ▁been ▁found ▁to ▁act ▁as ▁an ▁in hib itor , ▁to ▁varying ▁ext ents , ▁of ▁a ▁variety ▁of ▁ster oid ogen ic ▁en zym es , ▁including ▁ch ol ester ol ▁side - chain ▁cle av age ▁en zym e , ▁ 3 β - h ydro x yst ero id ▁de h ydro gen ase / Δ 5 - 4 ▁is omer ase , ▁ 1 7 α - h ydro x yl ase , ▁ 1 7 , 2 0 - ly ase , ▁ 1 7 β -