▁of ▁col ore ct al ▁cancer , ▁end omet rial ▁cancer , ▁o var ian ▁cancer , ▁upper ▁g astro int est inal ▁( g astr ic , ▁du oden al , ▁b ile ▁du ct ▁or ▁pan cre atic ), ▁ur inary ▁tract ▁can cers , ▁pro state ▁cancer ▁and ▁brain ▁tum ours ▁were ▁as ▁follows : ▁for ▁ML H 1 ▁mut ations ▁the ▁risk ▁was ▁- ▁ 4 6 %, ▁ 4 3 %, ▁ 1 0 %, ▁ 2 1 %, ▁ 8 %, ▁ 1 7 % ▁and ▁ 1 % ▁respectively : ▁for ▁M SH 2 ▁mut ations ▁the ▁ris ks ▁were ▁ 5 7 %, ▁ 1 7 %, ▁ 1 0 %, ▁ 2 5 %, ▁ 3 2 %, ▁and ▁ 5 % ▁respectively : ▁for ▁M SH 6 ▁mut ations ▁the ▁ris ks ▁were ▁ 1 5 %, ▁ 4 6 %, ▁ 1 3 %, ▁ 7 %, ▁ 1 1 %, ▁ 1 8 % ▁and ▁ 1 % ▁respectively . ▁ ▁Gen et ics ▁▁▁ ▁H NP CC ▁is ▁inherited ▁in ▁an ▁aut os om al ▁dominant ▁fashion . ▁The ▁hall mark ▁of ▁H NP CC ▁is ▁defect ive ▁DNA ▁mismatch ▁repair , ▁which ▁leads ▁to ▁mic ros at ellite ▁inst ability , ▁also ▁known ▁as ▁M SI - H ▁( the ▁H ▁is ▁" high "). ▁M SI ▁is ▁ident ifiable ▁in ▁cancer ▁spec im ens ▁in ▁the ▁path ology ▁labor atory . ▁Most ▁cases ▁result ▁in ▁changes ▁in ▁the