▁on ▁gen ot ype . ▁ ▁One ▁of ▁these ▁clusters ▁( gen ot ype ▁I ) ▁is ▁widely ▁distributed ▁among ▁several ▁Asian ▁countries , ▁including ▁ 1 3 ▁isol ates ▁from ▁Korea , ▁nine ▁isol ates ▁from ▁Japan , ▁one ▁from ▁Th ailand , ▁one ▁from ▁China , ▁and ▁one ▁from ▁the ▁South ▁China ▁Sea . ▁ ▁In ▁contrast , ▁the ▁other ▁two ▁gen ot ypes ▁had ▁a ▁smaller ▁host ▁range ▁and ▁were ▁locally ▁distributed . ▁ ▁Gen ot ype ▁II ▁meg al oc yt iv ir uses ▁inf ected ▁fresh water ▁fish es ▁from ▁S out heast ▁Asia ▁and ▁Australia , ▁whereas ▁gen ot ype ▁III ▁meg al oc yt iv ir uses ▁inf ected ▁primarily ▁flat fish ▁in ▁China ▁and ▁Korea . ▁ ▁Path ology ▁ ▁In fection ▁with ▁these ▁vir uses ▁produces ▁a ▁characteristic ▁presence ▁of ▁en larg ed ▁bas oph il ic ▁cells ▁within ▁inf ected ▁org ans . ▁ ▁Str ucture ▁and ▁rep lication ▁ ▁Meg al oc yt iv ir uses ▁are ▁large ▁ icos ah ed ral ▁DNA ▁vir uses ▁meas uring ▁ 1 5 0 - 2 5 0   nm ▁in ▁diameter ▁with ▁a ▁large ▁single ▁linear ▁ds D NA ▁gen ome . ▁ ▁Meg al ov ir uses ▁are ▁assumed ▁to ▁rep licate ▁in ▁the ▁same ▁fashion ▁as ▁other ▁I rid ov ir uses , ▁and ▁attach ▁to ▁the ▁host ▁cell ▁and ▁enter ▁by ▁re ceptor - medi ated ▁end oc yt osis . ▁ ▁Un co ated ▁vir al ▁particles ▁subsequently ▁trans