▁ 6 q 2 4 - related ▁to ▁T ND M . ▁Norm ally , ▁the ▁birth ▁weight ▁in ▁inf ants ▁are ▁lower ▁in ▁chrom os ome ▁ 6 q 2 4 ▁T ND M ▁patients ▁and ▁di ab etes ▁is ▁initi ated ▁at ▁an ▁earlier ▁age ▁( similar ▁to ▁read mission ). ▁There ▁may ▁be ▁an ▁overlap ▁between ▁chrom os ome ▁ 6 q 2 4 ▁and ▁K CN J 1 1 ▁and ▁AB CC 8 - related ▁T ND M , ▁making ▁gen etic ▁diagn osis ▁necessary ▁for ▁treatment . ▁ ▁IN S ▁Gene ▁ ▁Rec ess ive ▁mut ations ▁in ▁the ▁IN S ▁gene ▁encoding ▁ins ul in ▁were ▁discovered ▁to ▁trigger ▁both ▁P ND M ▁and ▁T ND M . ▁Di ab etes ▁occurs ▁because ▁there ▁is ▁an ▁decrease ▁ins ul in ▁b ios yn thesis ▁as ▁a ▁result ▁of ▁hom o zy g ous ▁mut ations . ▁Common ▁phen ot ype ▁is ▁decre ased ▁birth ▁weight ▁and ▁average ▁age ▁of ▁diagn osis ▁is ▁one ▁week . ▁Pre vious ▁studies ▁show ▁re lapse ▁of ▁di ab etes ▁occurred ▁at ▁an ▁average ▁age ▁of ▁ 2 6 ▁weeks . ▁ ▁P erman ent ▁Ne on atal ▁Di ab etes ▁M ell it us ▁( P ND M ) ▁ ▁P ND M ▁is ▁associated ▁with ▁mut ations ▁in ▁the ▁B eta - cell ▁ATP ▁sensitive ▁pot ass ium ▁channel ▁( K AT P ) ▁initi ated ▁by ▁heter o zy g ous ▁leading ▁to ▁mut ations ▁in ▁K CN J