▁St em ▁Cell ▁trans plant ▁found ▁to ▁be ▁effective ▁and ▁l ys os om al ▁en zym e ▁levels ▁seemed ▁to ▁normal ize ▁after ▁trans plant ▁in ▁at ▁least ▁one ▁case . ▁The ▁P all ister – H all ▁synd rome , ▁a ▁development al ▁dis order , ▁in ▁another ▁example , ▁where ▁a ▁functional ▁dis order ▁of ▁a ▁key ▁development al ▁gene ▁results ▁from ▁a ▁de ▁nov o ▁insert ion ▁of ▁a ▁ 7 2 bp ▁m t D NA ▁fragment ▁into ▁G LI 3 ▁ex on ▁ 1 4 ▁in ▁chrom os ome ▁ 7 , ▁which ▁results ▁in ▁central ▁and ▁post ax ial ▁pol yd act y ly , ▁b if id ▁ep ig l ott is , ▁imper for ate ▁an us , ▁ren al ▁ab normal ities ▁including ▁c yst ic ▁mal form ations , ▁ren al ▁hyp op las ia , ▁e ct op ic ▁u re ter al ▁impl ant ation , ▁and ▁pul mon ary ▁segment ation ▁anom al ies ▁such ▁as ▁bil ater al ▁bil ob ed ▁l ungs . ▁A ▁sp lice ▁site ▁mut ation ▁in ▁the ▁human ▁gene ▁for ▁pl asma ▁factor ▁VII ▁that ▁causes ▁severe ▁pl asma ▁factor ▁VII ▁def ic iency , ▁ble eding ▁disease , ▁results ▁from ▁a ▁ 2 5 1 - bp ▁NUM T ▁insert ion . ▁As ▁the ▁last ▁known ▁example , ▁a ▁ 3 6 - bp ▁insert ion ▁in ▁ex on ▁ 9 ▁of ▁the ▁US H 1 C ▁gene ▁associated ▁with ▁U sh