negative . ▁The ▁presentation ▁with ▁M SH 6 ▁is ▁slightly ▁different ▁than ▁with ▁ML H 1 ▁and ▁M SH 2 , ▁and ▁the ▁term ▁" MS H 6 ▁synd rome " ▁has ▁been ▁used ▁to ▁describe ▁this ▁condition . ▁In ▁one ▁study , ▁the ▁Beth es da ▁gu idel ines ▁were ▁more ▁sensitive ▁than ▁the ▁Amsterdam ▁C riteria ▁in ▁detect ing ▁it . ▁ ▁Up ▁to ▁ 3 9 % ▁of ▁families ▁with ▁mut ations ▁in ▁an ▁H NP CC ▁gene ▁do ▁not ▁meet ▁the ▁Amsterdam ▁criteria . ▁Therefore , ▁families ▁found ▁to ▁have ▁a ▁de le ter ious ▁mut ation ▁in ▁an ▁H NP CC ▁gene ▁should ▁be ▁considered ▁to ▁have ▁H NP CC ▁regardless ▁of ▁the ▁extent ▁of ▁the ▁family ▁history . ▁This ▁also ▁means ▁that ▁the ▁Amsterdam ▁criteria ▁fail ▁to ▁identify ▁many ▁people ▁who ▁are ▁at ▁risk ▁for ▁Lyn ch ▁synd rome . ▁Im pro ving ▁the ▁criteria ▁for ▁screen ing ▁is ▁an ▁active ▁area ▁of ▁research , ▁as ▁detailed ▁in ▁the ▁Screen ing ▁Str ateg ies ▁section ▁of ▁this ▁article . ▁ ▁Most ▁people ▁with ▁H NP CC ▁inherit ▁the ▁condition ▁from ▁a ▁parent . ▁However , ▁due ▁to ▁incomplete ▁pen et rance , ▁variable ▁age ▁of ▁cancer ▁diagn osis , ▁cancer ▁risk ▁reduction , ▁or ▁early ▁death , ▁not ▁all ▁people ▁with ▁an ▁H NP CC ▁gene ▁mut ation ▁have ▁a ▁parent ▁who ▁had ▁cancer . ▁Some ▁people ▁develop ▁H NP CC ▁de - n ovo ▁in ▁a ▁new ▁generation , ▁without ▁inher iting ▁the ▁gene . ▁These