or rh age , ▁inf ar ction , ▁or ▁pan cre at itis ▁In vol vement ▁of ▁the ▁central ▁nerv ous ▁system ▁Card iom y op ath y ▁ ▁The ▁lack ▁of ▁any ▁of ▁these ▁factors ▁indicates ▁mil der ▁case , ▁with ▁a ▁five - year ▁mort ality ▁rate ▁of ▁ 1 1 . 9 %. ▁The ▁presence ▁of ▁one ▁factor ▁indicates ▁severe ▁disease , ▁with ▁a ▁five - year ▁mort ality ▁rate ▁of ▁ 2 6 %, ▁and ▁two ▁or ▁more ▁indicate ▁very ▁severe ▁disease : ▁ 4 6 % ▁five - year ▁mort ality ▁rate . ▁ ▁Tre at ment ▁ ▁Tre at ment ▁for ▁e os in oph il ic ▁gran ul om atos is ▁with ▁poly ang i itis ▁includes ▁gl uc oc ort ico ids ▁( such ▁as ▁pred nis ol one ) ▁and ▁other ▁imm unos upp ress ive ▁dru gs ▁( such ▁as ▁az ath iop r ine ▁and ▁cy clo ph osph am ide ). ▁In ▁many ▁cases , ▁the ▁disease ▁can ▁be ▁put ▁into ▁a ▁type ▁of ▁chemical ▁rem ission ▁through ▁drug ▁ther apy , ▁but ▁the ▁disease ▁is ▁chron ic ▁and ▁lif el ong . ▁ ▁A ▁system atic ▁review ▁conducted ▁in ▁ 2 0 0 7 ▁indicated ▁all ▁patients ▁should ▁be ▁treated ▁with ▁high - d ose ▁ster oid s , ▁but ▁in ▁patients ▁with ▁a ▁five - factor ▁score ▁of ▁one ▁or ▁higher , ▁cy clo ph osph am ide ▁pul se ▁ther apy ▁should ▁be ▁comm enced , ▁with ▁