▁p neum onia e , ▁and ▁van com yc in - res istant ▁enter oc oc ci . ▁ ▁Com position ▁ ▁N osi he pt ide ▁consists ▁of ▁ 5 ▁th ia z ole ▁rings , ▁a ▁central ▁t et ras ub st it uted ▁py rid ine ▁mo iety , ▁and ▁a ▁b icy clic ▁macro cycle , ▁which ▁includes ▁a ▁modified ▁am ino ▁acid ▁( from ▁try pt oph an ) ▁external ▁to ▁the ▁initial ▁pe pt ide ▁translated ▁from ▁the ▁gene ▁encoding ▁it . ▁It ▁is ▁used ▁as ▁a ▁feed ▁add itive ▁in ▁the ▁growth ▁of ▁p oul try ▁and ▁h ogs ▁to ▁promote ▁growth ▁and ▁general ▁health , ▁although ▁it ▁has ▁not ▁been ▁applied ▁in ▁human ▁medic ines ▁due ▁to ▁low ▁water ▁sol ub ility ▁and ▁poor ▁res or ption ▁from ▁the ▁g astro int est inal ▁tract . ▁N osi he pt ide ▁and ▁other ▁th io pe pt ide ' s ▁mechanism ▁of ▁action ▁st ems ▁from ▁the ▁tight ▁binding ▁on ▁the ▁ 5 0 S ▁rib os om al ▁sub unit ▁and ▁in hib iting ▁the ▁activities ▁of ▁el ong ation ▁factors , ▁prevent ing ▁protein ▁synth esis . ▁ ▁B ios yn thesis ▁▁ ▁All ▁mo iet ies ▁of ▁the ▁pe pt id yl ▁back bone ▁of ▁nos ihe pt ide ▁were ▁shown ▁to ▁origin ate ▁exclus ively ▁from ▁protein ogen ic ▁am ino ▁ac ids . ▁The ▁struct ural ▁mot ifs ▁include ▁de h ydro am ino ▁ac ids ▁from ▁the ▁ser ine