: Parent ing ▁Category : Inter person al ▁relationships <0x0A> </s> ▁The ▁Cook – He il br on ▁th ia z ole ▁synth esis ▁highlight s ▁the ▁formation ▁of ▁ 5 - amin oth ia z oles ▁through ▁the ▁chemical ▁reaction ▁of ▁α - amin on it ril es ▁or ▁am in oc yn o ac et ates ▁with ▁d ith io ac ids , ▁carbon ▁dis ul ph ide , ▁carbon ▁ox ys ulf ide , ▁or ▁is oth i oc yn ates ▁at ▁room ▁temperature ▁and ▁under ▁m ild ▁or ▁a que ous ▁conditions . ▁Vari ation ▁of ▁subst itu ents ▁at ▁the ▁ 2 nd ▁and ▁ 4 th ▁position ▁of ▁the ▁th ia z ole ▁is ▁introduced ▁by ▁selecting ▁different ▁combinations ▁of ▁starting ▁re ag ents . ▁ ▁This ▁reaction ▁was ▁first ▁discovered ▁in ▁ 1 9 4 7 ▁by ▁Alan ▁H . ▁Cook , ▁Sir ▁Ian ▁Heil br on , ▁and ▁A . L ▁Le vy , ▁and ▁marks ▁one ▁of ▁the ▁first ▁examples ▁of ▁ 5 - amin oth ia z ole ▁synth esis ▁with ▁significant ▁yield ▁and ▁divers ity ▁in ▁scope . ▁Prior ▁to ▁their ▁discovery , ▁ 5 - amin oth ia z oles ▁were ▁a ▁relatively ▁unknown ▁class ▁of ▁comp ounds , ▁but ▁were ▁of ▁synth etic ▁interest ▁and ▁utility . ▁Their ▁premier ▁publication ▁illustrated ▁the ▁formation ▁of ▁ 5 - am ino - 2 - ben zy l th ia z ole ▁and ▁ 5 - am ino - 4 - car b