es ▁on ▁how ▁chrom atin - based ▁and ▁ep igen etic ▁mechan isms ▁contribute ▁to ▁the ▁ways ▁in ▁which ▁gene ▁expression ▁is ▁reg ulated . ▁ ▁Education ▁K lose ▁was ▁an ▁under grad uate ▁student ▁at ▁the ▁University ▁of ▁Water lo o ▁in ▁Ontario , ▁Canada , ▁where ▁he ▁graduated ▁with ▁Dean ' s ▁Hon ors ▁in ▁Bi ology . ▁As ▁a ▁post grad uate ▁student ▁under ▁Prof . ▁Sir ▁Ad rian ▁Bird ▁at ▁the ▁Well come ▁Centre ▁for ▁Cell ▁Bi ology ▁at ▁the ▁University ▁of ▁Edinburgh , ▁Scotland , ▁he ▁studied ▁the ▁m eth yl ▁C p G ▁binding ▁protein ▁Me CP 2 , ▁part ▁of ▁the ▁DNA ▁m eth yl ation ▁system , ▁which ▁is ▁associated ▁with ▁R ett ▁synd rome . ▁He ▁obtained ▁his ▁Doctor ▁of ▁Philosoph y ▁in ▁ 2 0 0 5 . ▁ ▁Career ▁and ▁research ▁K lose ▁spent ▁two ▁years ▁as ▁a ▁post do ctor al ▁research er ▁in ▁the ▁lab ▁of ▁Y i ▁Z hang , ▁who ▁was ▁based ▁at ▁the ▁University ▁of ▁North ▁Carolina ▁at ▁Chap el ▁Hill , ▁ident ifying ▁a ▁novel ▁family ▁of ▁hist one ▁l ys ine ▁dem eth yl ase ▁en zym es . ▁He ▁then ▁moved ▁to ▁the ▁University ▁of ▁Oxford ▁where , ▁in ▁ 2 0 0 8 , ▁he ▁established ▁himself ▁as ▁a ▁Princi pal ▁Investig ator ▁at ▁the ▁Department ▁of ▁Bio chem istry ▁at ▁Oxford ▁supported ▁by ▁a ▁Well come ▁Trust ▁career ▁development ▁fellow ship . ▁Five ▁years ▁after ▁this , ▁he ▁secured ▁a ▁Well come