▁terminal s ▁after ▁a ▁dis charge , ▁thereby ▁allowing ▁more ▁calci um ▁to ▁accum ulate ▁in ▁the ▁n erve ▁terminal . ▁ ▁Py rid ost ig mine ▁decre ases ▁the ▁de grad ation ▁of ▁ac et yl ch oline ▁after ▁release ▁into ▁the ▁syn apt ic ▁c left , ▁and ▁thereby ▁impro ves ▁mus cle ▁contra ction . ▁An ▁older ▁agent , ▁gu an id ine , ▁causes ▁many ▁side ▁effects ▁and ▁is ▁not ▁recommended . ▁ 4 - A min opy rid ine ▁( d alf am pr id ine ), ▁an ▁agent ▁related ▁to ▁ 3 , 4 - amin opy rid ine , ▁causes ▁more ▁side ▁effects ▁than ▁ 3 , 4 - D AP ▁and ▁is ▁also ▁not ▁recommended . ▁ ▁History ▁Anderson ▁and ▁colle agues ▁from ▁St ▁Thomas ' ▁Hospital , ▁London , ▁were ▁the ▁first ▁to ▁mention ▁a ▁case ▁with ▁possible ▁clin ical ▁find ings ▁of ▁LE MS ▁in ▁ 1 9 5 3 , ▁but ▁Lam bert , ▁E aton , ▁and ▁Ro oke ▁at ▁the ▁May o ▁C lin ic ▁were ▁the ▁first ▁phys icians ▁to ▁substantial ly ▁describe ▁the ▁clin ical ▁and ▁electro phys i ological ▁find ings ▁of ▁the ▁disease ▁in ▁ 1 9 5 6 . ▁In ▁ 1 9 7 2 , ▁the ▁clust ering ▁of ▁LE MS ▁with ▁other ▁auto imm une ▁dise ases ▁led ▁to ▁the ▁hypothesis ▁that ▁it ▁was ▁caused ▁by ▁auto imm unity . ▁Studies ▁in ▁the ▁ 1 9 8 0 s ▁confirmed ▁the ▁auto imm