▁the ▁DNA ▁into ▁the ▁nucle us . ▁The ▁structure ▁var ies ▁depending ▁on ▁the ▁access ▁required ▁to ▁the ▁DNA . ▁Gen es ▁that ▁require ▁regular ▁access ▁by ▁R NA ▁polym er ase ▁require ▁the ▁lo oser ▁structure ▁provided ▁by ▁e uch rom atin . ▁ ▁Met aph ase : ▁The ▁met aph ase ▁structure ▁of ▁chrom atin ▁diff ers ▁vast ly ▁to ▁that ▁of ▁inter phase . ▁It ▁is ▁optim ised ▁for ▁physical ▁strength ▁and ▁manage ability , ▁forming ▁the ▁classic ▁chrom os ome ▁structure ▁seen ▁in ▁k ary ot ypes . ▁The ▁structure ▁of ▁the ▁cond ensed ▁chrom atin ▁is ▁thought ▁to ▁be ▁loops ▁of ▁ 3 0   nm ▁fib re ▁to ▁a ▁central ▁sc aff old ▁of ▁prote ins . ▁It ▁is , ▁however , ▁not ▁well - character ised . The ▁physical ▁strength ▁of ▁chrom atin ▁is ▁vital ▁for ▁this ▁stage ▁of ▁division ▁to ▁prevent ▁she ar ▁damage ▁to ▁the ▁DNA ▁as ▁the ▁daughter ▁chrom os om es ▁are ▁separated . ▁To ▁maxim ise ▁strength ▁the ▁composition ▁of ▁the ▁chrom atin ▁changes ▁as ▁it ▁approaches ▁the ▁cent rom ere , ▁primarily ▁through ▁alternative ▁hist one ▁H 1 ▁analog ues . ▁During ▁mit osis , ▁although ▁most ▁of ▁the ▁chrom atin ▁is ▁tight ly ▁compact ed , ▁there ▁are ▁small ▁regions ▁that ▁are ▁not ▁as ▁tight ly ▁compact ed . ▁These ▁regions ▁often ▁correspond ▁to ▁prom oter ▁regions ▁of ▁gen es ▁that ▁were ▁active ▁in ▁that ▁cell ▁type ▁prior ▁to ▁entry ▁into ▁chrom atos is . ▁The ▁lack ▁of ▁comp