▁in hib ition ▁of ▁ β - c aten in ▁dependent ▁trans cription . ▁Rec ently , ▁several ▁small - m ole c ule ▁comp ounds ▁have ▁also ▁been ▁developed ▁to ▁target ▁the ▁same , ▁highly ▁posit ively ▁charged ▁area ▁of ▁the ▁AR M ▁domain ▁( CG P 0 4 9 0 9 0 , ▁PK F 1 1 8 - 3 1 0 , ▁PK F 1 1 5 - 5 8 4 ▁and ▁Z TM 0 0 0 9 9 0 ). ▁In ▁addition , ▁ β - c aten in ▁levels ▁can ▁also ▁be ▁influenced ▁by ▁target ing ▁up stream ▁components ▁of ▁the ▁W nt ▁path way ▁as ▁well ▁as ▁the ▁ β - c aten in ▁destruction ▁complex . ▁The ▁additional ▁N - term inal ▁binding ▁pocket ▁is ▁also ▁important ▁for ▁W nt ▁target ▁gene ▁activation ▁( required ▁for ▁B CL 9 ▁rec ruit ment ). ▁This ▁site ▁of ▁the ▁AR M ▁domain ▁can ▁be ▁ph arm ac olog ically ▁target ed ▁by ▁car nos ic ▁acid , ▁for ▁example . ▁That ▁" aux ili ary " ▁site ▁is ▁another ▁attract ive ▁target ▁for ▁drug ▁development . ▁Despite ▁int ensive ▁pre cl in ical ▁research , ▁no ▁ β - c aten in ▁in hib itors ▁are ▁available ▁as ▁th era pe ut ic ▁agents ▁yet . ▁However , ▁its ▁function ▁can ▁be ▁further ▁exam ined ▁by ▁si R NA ▁knock down ▁based ▁on ▁an ▁independent ▁validation . ▁Another ▁th era pe ut ic ▁approach ▁for ▁reducing ▁ β