▁AA ▁am y lo idos is ▁is ▁a ▁form ▁of ▁am y lo idos is , ▁a ▁disease ▁character ized ▁by ▁the ▁ab normal ▁de position ▁of ▁fib ers ▁of ▁ins ol ub le ▁protein ▁in ▁the ▁ext rac ell ular ▁space ▁of ▁various ▁t issues ▁and ▁org ans . ▁In ▁AA ▁am y lo idos is , ▁the ▁depos ited ▁protein ▁is ▁ser um ▁am y lo id ▁A ▁protein ▁( S AA ), ▁an ▁ac ute - phase ▁protein ▁which ▁is ▁normally ▁sol ub le ▁and ▁whose ▁pl asma ▁concentration ▁is ▁highest ▁during ▁infl amm ation . ▁ ▁C aus es ▁ ▁AA ▁am y lo idos is ▁is ▁a ▁comp lication ▁of ▁a ▁number ▁of ▁infl am mat ory ▁dise ases ▁and ▁in fe ctions , ▁although ▁only ▁a ▁small ▁portion ▁of ▁patients ▁with ▁these ▁conditions ▁will ▁go ▁on ▁to ▁develop ▁AA ▁am y lo idos is . ▁The ▁most ▁common ▁presentation ▁of ▁AA ▁am y lo idos is ▁is ▁ren al ▁in ▁nature , ▁including ▁protein uria , ▁ne ph rot ic ▁synd rome ▁ ▁and ▁progress ive ▁development ▁of ▁chron ic ▁kid ney ▁disease ▁leading ▁to ▁End ▁Stage ▁Kid ney ▁D ise ase ▁( ES K D ) ▁and ▁need ▁for ▁ren al ▁replacement ▁ther apy ▁( e . g . ▁d ial ysis ▁or ▁kid ney ▁trans plant ation ). ▁A ▁natural ▁history ▁study ▁of ▁AA ▁am y lo idos is ▁patients ▁reported ▁a ▁number ▁of ▁conditions ▁associated ▁with ▁AA ▁am y lo idos is : ▁▁