2 , ▁formed ▁by ▁the ▁e os in oph il , ▁and ▁either ▁ch lor ide ▁or ▁b rom ide ▁ ions , ▁e os in oph il ▁per ox id ase ▁provides ▁a ▁pot ent ▁mechanism ▁by ▁which ▁e os in oph ils ▁kill ▁mult ic ell ular ▁par as ites ▁( such ▁as , ▁for ▁example , ▁the ▁n emat ode ▁w orm s ▁involved ▁in ▁fil arias is ) ▁and ▁some ▁b acter ia ▁( such ▁as ▁t uber cul osis ▁b acter ia ). ▁E os in oph il ▁per ox id ase ▁is ▁a ▁hal op ero x id ase ▁that ▁prefer entially ▁uses ▁b rom ide ▁over ▁ch lor ide ▁for ▁this ▁purpose , ▁generating ▁hyp ob rom ite ▁( h yp ob rom ous ▁acid ), ▁although ▁the ▁use ▁of ▁ch lor ide ▁is ▁possible . ▁ ▁α - H alo esters ▁are ▁generally ▁thought ▁of ▁as ▁highly ▁re active ▁and ▁consequ ently ▁to xic ▁inter medi ates ▁in ▁organ ic ▁synth esis . ▁Nevertheless , ▁m amm als , ▁including ▁humans , ▁c ats , ▁and ▁r ats , ▁appear ▁to ▁b ios yn thes ize ▁traces ▁of ▁an ▁α - b rom o ester , ▁ 2 - oct yl ▁ 4 - b rom o - 3 - ox ob ut ano ate , ▁which ▁is ▁found ▁in ▁their ▁c ere bro sp inal ▁fluid ▁and ▁appears ▁to ▁play ▁a ▁yet ▁un clar ified ▁role ▁in ▁indu cing ▁RE M ▁sleep . ▁Ne