. ▁C yt olog ic ▁exam ination ▁of ▁pap ul op ust ular ▁les ions ▁of ▁ju ven ile ▁cell ul itis ▁reve als ▁py og ran ul om at ous ▁infl amm ation ▁with ▁no ▁micro organ isms ▁and ▁carefully ▁performed ▁cult ures ▁are ▁negative . ▁Bi ops ies ▁of ▁early ▁les ions ▁reve al ▁multiple ▁discrete ▁or ▁confl uent ▁gran ul omas ▁and ▁py og ran ul omas ▁consisting ▁of ▁clusters ▁of ▁large ▁ep ith el io id ▁macro ph ages ▁with ▁vari ably ▁s ized ▁cores ▁of ▁neut roph ils . ▁C yt ological ▁analysis ▁of ▁joint ▁fluid ▁often ▁reve als ▁ster ile ▁supp ur ative ▁ar th rit is . ▁ ▁Tre at ment ▁ ▁Lar ge ▁dos es ▁of ▁gl uc oc ort ico ids ▁are ▁the ▁treatment ▁of ▁choice , ▁and ▁are ▁admin ister ed ▁until ▁the ▁signs ▁have ▁resolved . ▁In ▁un comp licated ▁cases , ▁this ▁can ▁take ▁up ▁to ▁a ▁month . ▁If ▁dogs ▁are ▁not ▁treated ▁prompt ly ▁and ▁with ▁high ▁dos es ▁of ▁ster oid s , ▁severe ▁sc arring ▁may ▁occur . ▁If ▁there ▁is ▁evidence ▁of ▁secondary ▁b acter ial ▁in fection , ▁treatment ▁with ▁ant ib iot ics ▁is ▁required . ▁ ▁References ▁▁ ▁Category : D og ▁dise ases <0x0A> </s> ▁Mar ston ▁is ▁a ▁civil ▁parish ▁in ▁the ▁Bor ough ▁of ▁Staff ord , ▁Staff ord shire , ▁England . ▁ ▁It ▁contains ▁two ▁listed ▁buildings ▁that ▁are ▁recorded ▁in ▁the ▁National ▁Heritage ▁List ▁for ▁England .