. ▁ ▁As ▁a ▁path ogen ▁recognition ▁protein ▁with ▁ant im icro b ial ▁properties , ▁P GL Y R P - 1 ▁is ▁sus pected ▁to ▁play ▁an ▁important ▁role ▁in ▁maintain ing ▁the ▁gut ▁micro b ial ▁fl ora . ▁ ▁Mechan ism ▁of ▁action ▁ ▁As ▁an ▁ant im icro b ial , ▁the ▁binding ▁of ▁P GL Y R P 1 ▁to ▁its ▁target ▁does ▁not ▁per me abil ize ▁the ▁b acter ial ▁cell ▁wall ▁like ▁def ens ins ▁and ▁other ▁ant im icro b ial ▁pe pt ides . ▁ ▁Instead , ▁P GL Y R P 1 ▁binding ▁activ ates ▁a ▁b acter ial ▁stress ▁response ▁that ▁causes ▁the ▁b acter ium ▁to ▁shut ▁down ▁trans cription ▁and ▁translation , ▁and ▁indu ces ▁ox id ative ▁stress . ▁As ▁a ▁c yt ot ox ic ▁agent , ▁the ▁P GL Y R P 1 - H SP 7 0 ▁complex ▁ ▁Possible ▁path ological ▁role ▁ ▁In ▁humans , ▁single ▁nuclear ▁polym orph isms ▁of ▁the ▁P GL Y R P 1 ▁gene ▁have ▁been ▁associated ▁with ▁the ▁development ▁of ▁ul cer ative ▁col itis . ▁ ▁In ▁m ice , ▁the ▁lack ▁of ▁P GL Y R P 1 ▁is ▁associated ▁with ▁increased ▁sus cept ibility ▁to ▁inf ect ious ▁disease , ▁but ▁also ▁decre ased ▁sus cept ibility ▁to ▁auto imm une ▁disease . ▁The ▁lack ▁of ▁P GL Y R P 1 ▁was ▁found ▁to ▁have ▁increased ▁sus cept ibility ▁to ▁cor ne