▁Function ▁▁ ▁G AP VD 1 ▁is ▁Rab ▁G TP ase ▁gu an ine ▁nucle ot ide ▁exchange ▁factor ▁essential ▁for ▁activation ▁of ▁R AB 5 A ▁during ▁eng ulf ment ▁of ▁apo pt otic ▁cells . ▁G AP VD 1 ▁is ▁also ▁involved ▁in ▁the ▁de grad ation ▁of ▁the ▁e pid erm al ▁growth ▁factor ▁re ceptor . ▁G ape x - 5 ▁medi ated ▁activation ▁of ▁Rab 5 ▁has ▁been ▁imp licated ▁in ▁the ▁ins ul in ▁stim ulated ▁formation ▁of ▁pl asma ▁memb rane ▁ph osph at id y lin os it ol - 3 - ph osph ate . ▁ ▁Str ucture ▁ ▁Based ▁on ▁sequence ▁hom ology , ▁m amm al ian ▁G ape x - 5 ▁has ▁been ▁shown ▁to ▁have ▁an ▁am ino - term inal ▁Ras ▁G AP ▁domain , ▁a ▁central ▁poly pro line ▁( SH 3 ▁binding ) ▁region ▁and ▁a ▁car box y - term inal ▁Rab ▁G EF ▁domain . ▁The ▁Rab GE F ▁domain ▁has ▁been ▁suggested ▁to ▁activ ate ▁Rab 5 ▁and ▁Rab 3 1 . ▁ ▁References ▁ ▁Further ▁reading <0x0A> </s> ▁David ▁Taylor ▁Ch ast ain ▁( born ▁August ▁ 3 1 , ▁ 1 9 5 3 ) ▁is ▁an ▁American ▁guitar ist , ▁and ▁owner ▁of ▁Le vi athan ▁Records ▁and ▁D igin et ▁Music . ▁ ▁Ch ast ain ▁is ▁a ▁heavy ▁metal ▁guitar ist ▁who ▁emer ged ▁in ▁the ▁mid - 1 9 8 0 s ▁along ▁with ▁a ▁wave ▁of ▁other