▁been ▁shown ▁to ▁have ▁ab normal ▁gl uc ose ▁met abol ism ▁in ▁these ▁areas , ▁also ▁adding ▁to ▁the ▁conclusion ▁that ▁est ro gen ▁has ▁a ▁direct ▁relation ▁to ▁the ▁development ▁of ▁Al z heimer ' s . ▁ ▁Tre at ment ▁H orm one ▁ther apy ▁also ▁known ▁as ▁est ro gen ▁ther apy ▁is ▁the ▁most ▁common ▁treatment ▁for ▁men op aus al ▁sympt oms . ▁ ▁C ogn ition ▁ ▁Est ro gen ▁has ▁direct ▁effects ▁on ▁the ▁hi pp oc amp us , ▁which ▁in ▁turn ▁rel ates ▁to ▁m ood , ▁including ▁increasing ▁d end rit ic ▁sp ine ▁density ▁and ▁increasing ▁the ▁volume ▁and ▁ne uro gen esis ▁of ▁the ▁hi pp osc amp us ; ▁these ▁are ▁key ▁to ▁greater ▁cogn ition ▁as ▁key ▁neur onal ▁circ uits ▁are ▁maintained . ▁Ph arma ce ut ical ▁companies ▁are ▁currently ▁developing ▁est ro gen ▁re ceptor ▁lig ands ▁as ▁anti - infl am mat ory ▁agents ▁to ▁reduce ▁ne uro infl amm ation ▁of ▁micro gl ia ▁which ▁leads ▁to ▁ne uro de gener ative ▁dis orders . ▁However , ▁other ▁cell ular ▁targets ▁may ▁over take ▁the ▁focus ▁of ▁the ▁est ro gen ▁treatment ▁as ▁est ro gen ▁works ▁as ▁an ▁anti - ap opt otic ▁h orm one ▁for ▁neur ons , ▁indu ces ▁growth ▁of ▁neural ▁stem ▁cells , ▁increases ▁ast rog li al ▁cells ▁ability ▁to ▁se crete ▁ne uro prote ct ive ▁mole cules ▁while ▁also ▁reducing ▁their ▁formation ▁of ▁ne