▁( an ▁ant it um or ▁ant ib i otic ▁that ▁acts ▁on ▁H sp 9 0 ) ▁to ▁mut ant ▁f lies ▁before ▁sympt oms ▁of ▁neural ▁decl ine ▁were ▁visible ▁a vert ed ▁the ▁on set ▁of ▁ne uro de gener ation ▁in ▁the ▁mut ant ▁f lies , ▁suggesting ▁a ▁new ▁approach ▁for ▁people ▁sus cept ible ▁to ▁Park inson ' s ▁disease ▁and ▁other ▁ne uro de gener ative ▁conditions . ▁ ▁Amy ot roph ic ▁later al ▁s cl eros is ▁( AL S / Lou ▁Ge hr ig ' s ▁D ise ase ) ▁Bon ini ' s ▁research ▁labor atory ▁developed ▁and ▁valid ated ▁a ▁D ros oph ila ▁model ▁for ▁famil ial ▁A LS , ▁then ▁used ▁an ▁A LS ▁model ▁to ▁evaluate ▁gen es ▁and ▁path ways ▁important ▁for ▁A LS ▁on set , ▁pro gression , ▁and ▁possible ▁treatment . ▁Through ▁these ▁studies , ▁Bon ini ' s ▁team , ▁in ▁collaboration ▁with ▁A aron ▁Git ler , ▁discovered ▁that ▁AT X N 2 ▁( the ▁gene ▁that ▁enc odes ▁the ▁protein ▁A tax in - 2 ) ▁was ▁a ▁disease ▁sus cept ibility ▁gene ▁for ▁A LS , ▁and ▁that ▁interrupt ing ▁the ▁interaction ▁between ▁T DP - 4 3 ▁and ▁A tax in - 2 ▁was ▁a ▁prom ising ▁target ▁for ▁tre ating ▁A LS ▁and ▁other ▁dise ases . ▁ ▁A ▁role ▁for ▁brain ▁micro R N As ▁in ▁ag ing ▁and ▁disease ▁The ▁Bon ini ▁lab ▁discovered ▁that ▁a