▁( GR K 2 ) ▁is ▁an ▁en zym e ▁that ▁in ▁humans ▁is ▁encoded ▁by ▁the ▁A DR B K 1 ▁gene . ▁GR K 2 ▁was ▁initially ▁called ▁B eta - adr ener g ic ▁re ceptor ▁kin ase ▁( β AR K ▁or ▁ β AR K 1 ), ▁and ▁is ▁a ▁member ▁of ▁the ▁G ▁protein - cou ple d ▁re ceptor ▁kin ase ▁sub family ▁of ▁the ▁Ser / T hr ▁protein ▁kin ases ▁that ▁is ▁most ▁highly ▁similar ▁to ▁GR K 3 ( β AR K 2 ). ▁ ▁Function s ▁▁ ▁G ▁protein - cou ple d ▁re ceptor ▁kin ases ▁ph osph ory late ▁activ ated ▁G ▁protein - cou ple d ▁re cept ors , ▁which ▁prom otes ▁the ▁binding ▁of ▁an ▁arrest in ▁protein ▁to ▁the ▁re ceptor . ▁Ar rest in ▁binding ▁to ▁ph osph ory l ated , ▁active ▁re ceptor ▁prevents ▁re ceptor ▁stim ulation ▁of ▁heter otr imer ic ▁G ▁protein ▁trans du cer ▁prote ins , ▁blocking ▁their ▁cell ular ▁signal ing ▁and ▁resulting ▁in ▁re ceptor ▁des ens it ization . ▁Ar rest in ▁binding ▁also ▁direct s ▁re cept ors ▁to ▁specific ▁cell ular ▁internal ization ▁path ways , ▁removing ▁the ▁re cept ors ▁from ▁the ▁cell ▁surface ▁and ▁also ▁prevent ing ▁additional ▁activation . ▁Ar rest in ▁binding ▁to ▁ph osph ory l ated , ▁active ▁re ceptor ▁also ▁enables ▁re ceptor ▁signal ing ▁through ▁arrest in ▁partner ▁prote ins . ▁Thus ▁the ▁GR K