▁n ause a , ▁loss ▁of ▁app et ite , ▁st om ach ▁dis com fort , ▁ab dom inal ▁pain , ▁di arr he a , ▁const ip ation , ▁dry ▁mouth , ▁taste ▁disturb ance , ▁d rows iness , ▁head ache , ▁d izz iness , ▁pal pit ations ▁and ▁m ala ise . ▁Less ▁than ▁ 0 . 1 % ▁of ▁patients ▁experienced ▁vom iting , ▁th rom b oc yt open ia , ▁ep ist axis , ▁ble eding ▁t endency , ▁ins om nia , ▁trem or , ▁num b ness , ▁hot ▁flush es ▁and ▁ed ema . ▁All ▁the ▁ad verse ▁re actions ▁reported ▁were ▁of ▁m ild ▁to ▁moder ate ▁sever ity , ▁and ▁resolved ▁when ▁the ▁drug ▁was ▁dis cont in ued . ▁ ▁Ph arm ac ology ▁Th rom box ane ▁A 2 ▁( TX A 2 ) ▁is ▁generated ▁in ▁the ▁l ungs ▁of ▁people ▁with ▁ast h ma , ▁and ▁when ▁it ▁signals ▁through ▁the ▁th rom box ane ▁re ceptor ▁it ▁causes ▁bron cho con str iction , ▁ ▁v aso con str iction , ▁m uc ous ▁secret ion , ▁and ▁air way ▁hyper - respons iveness . ▁Ser at rod ast ▁in hib its ▁the ▁activity ▁of ▁the ▁th rom box ane ▁re ceptor , ▁blocking ▁the ▁effects ▁of ▁T X A 2 . ▁ ▁Ph arm ac ok inet ics ▁The ▁ph arm ac ok inet ics ▁of ▁ser at rod ast ▁have ▁been ▁studied ▁in