▁signs ▁associated ▁with ▁in fection ▁are ▁n ons pec ific ▁and ▁may ▁include ▁app et ite ▁loss , ▁un co ordin ated ▁sw imming , ▁le th arg y , ▁co el omic ▁dist ention , ▁dark ening ▁skin ▁color , ▁p ete chia e , ▁fin ▁er os ion , ▁and ▁death . ▁ ▁Lar ge ▁consp ic uous ▁hy pert roph ied ▁cells , ▁for ▁which ▁the ▁genus ▁is ▁named , ▁are ▁evident ▁in ▁multiple ▁org ans ▁when ▁dise ased ▁t issues ▁are ▁exam ined ▁by ▁hist op ath ology ; ▁these ▁distinct ive ▁cells ▁are ▁commonly ▁observed ▁in ▁the ▁kid ney , ▁s ple en ▁and ▁g astro int est inal ▁tract ▁and ▁less ▁commonly ▁seen ▁in ▁the ▁li ver , ▁g ills , ▁heart , ▁and ▁connect ive ▁t issue . ▁ ▁The ▁hy pert roph ied ▁cells ▁are ▁frequently ▁per iv asc ular ▁in ▁distribution ▁and ▁are ▁greatly ▁en larg ed ▁due ▁to ▁large ▁gran ular ▁to ▁fo amy ▁bas oph il ic ▁cy top las mic ▁inclusion ▁bodies . ▁ ▁If ▁the ▁dist ended ▁cells ▁occ l ude ▁the ▁vas cul ature , ▁foc al ▁areas ▁of ▁is chem ic ▁ne c ros is ▁may ▁be ▁evident ▁within ▁various ▁org ans . ▁ ▁It ▁has ▁been ▁suggested ▁by ▁some ▁research ers ▁that ▁the ▁hy pert roph ied ▁cells ▁are ▁some ▁type ▁of ▁le uk ocy te , ▁which ▁is ▁consistent ▁with ▁their ▁t issue ▁distribution . ▁ ▁References ▁ ▁External ▁links ▁▁ ▁I CT V ▁Online ▁(