▁protein , ▁is ▁required ▁for ▁d ors al ▁migration ▁of ▁ax ons ▁in ▁n emat odes ; ▁it ▁was ▁determined ▁that ▁un c - 5 ▁acts ▁as ▁a ▁rep uls ive ▁re ceptor ▁for ▁Net rin ▁( unc - 6 ). ▁The ▁switch ▁between ▁attract ive ▁and ▁rep uls ive ▁net rin ▁signal ing ▁can ▁be ▁medi ated ▁by ▁mis expression ▁of ▁un c - 5 ▁in ▁comm iss ural ▁ax ons . ▁Net rin - 1 / D CC ▁binding ▁indu ces ▁D CC ▁hom od imer ization ▁leading ▁to ▁an ▁attract ive ▁response ; ▁on ▁the ▁other ▁hand , ▁the ▁chem ore p ell ent ▁response ▁is ▁triggered ▁via ▁net rin - 1 ▁binding ▁to ▁un c - 5 / D CC ▁heter od im ers . ▁ ▁Net rin ▁rep ulsion ▁can ▁also ▁be ▁medi ated ▁by ▁changes ▁in ▁cy clic ▁nucle ot ide ▁levels ; ▁net rin - 1 ▁indu ces ▁a ▁rep uls ive ▁response ▁when ▁c AMP ▁signal ing ▁is ▁in hib ited . ▁ ▁C is ▁interactions ▁of ▁net rin / D CC ▁( att ract ive ) ▁and ▁Sl it / Rob o ▁( rep uls ive ) ▁in ▁comm iss ural ▁ax ons ▁silence ▁both ▁signal ing ▁c ues ; ▁this ▁illustr ates ▁how ▁multiple ▁trop ic ▁c ues ▁interact ▁to ▁guide ▁the ▁comm iss ural ▁ax ons ▁to ▁their ▁targets . ▁ ▁Sl its ▁▁ ▁Rep uls ive ▁c ues ▁play ▁an ▁important ▁role ▁in ▁gu iding ▁growth ▁con es ▁to ▁their ▁appropriate