▁used ▁as ▁a ▁sol vent . ▁The ▁mut ar ot ation ▁of ▁sug ars ▁and ▁that ▁ 2 - py rid one ▁has ▁a ▁large ▁effect ▁on ▁the ▁reaction ▁from ▁activ ated ▁est ers ▁with ▁am ines ▁in ▁non pol ar ▁sol vent , ▁which ▁is ▁attributed ▁to ▁its ▁t aut omer isation ▁and ▁utility ▁as ▁a ▁dit op ic ▁re ceptor . ▁ ▁Current ▁interest ▁focus es ▁on ▁pro ton ▁transfer ▁from ▁ 2 - py rid one ▁and ▁its ▁t aut omer , ▁using ▁is ot ope ▁label ing , ▁k inet ics ▁and ▁quantum ▁chemical ▁methods ▁to ▁determine ▁the ▁rate ▁determ ining ▁step ▁in ▁the ▁reaction ▁mechanism . ▁ ▁Co ord ination ▁chem istry ▁ 2 - Py rid one ▁and ▁some ▁derivatives ▁serve ▁as ▁lig ands ▁in ▁coord ination ▁chem istry , ▁usually ▁as ▁a ▁ 1 , 3 - brid ging ▁lig and ▁a kin ▁to ▁car box yl ate . ▁ ▁In ▁nature ▁ 2 - Py rid one ▁is ▁not ▁naturally ▁occurr ing , ▁but ▁a ▁derivative ▁has ▁been ▁isolated ▁as ▁a ▁c of actor ▁in ▁certain ▁hydro gen ases . ▁ ▁Environment al ▁behavior ▁ 2 - Py rid one ▁is ▁rapidly ▁de grad ed ▁by ▁micro organ isms ▁in ▁the ▁soil ▁environment , ▁with ▁a ▁half ▁life ▁less ▁than ▁one ▁week . ▁ ▁Organ isms ▁capable ▁of ▁growth ▁on ▁ 2 - py rid one ▁as ▁a ▁sole ▁source ▁of ▁carbon , ▁nit ro gen , ▁and ▁energy ▁have ▁been ▁isolated ▁by ▁a ▁number