▁saved ; ▁and ▁the ▁safety ▁of ▁the ▁v acc ine ▁in ▁the ▁context ▁of ▁routine ▁use . ▁ ▁V acc in ations ▁by ▁the ▁minist ries ▁of ▁health ▁of ▁Mal aw i , ▁Gh ana , ▁and ▁Ken ya ▁began ▁in ▁April ▁and ▁September ▁ 2 0 1 9 ▁and ▁target ▁ 3 6 0 ▁ 0 0 0 ▁children ▁per ▁year ▁in ▁areas ▁where ▁v acc ination ▁would ▁have ▁the ▁highest ▁impact . ▁The ▁results ▁are ▁planned ▁to ▁be ▁used ▁by ▁the ▁World ▁Health ▁Organ ization ▁to ▁advise ▁about ▁a ▁possible ▁future ▁deployment ▁of ▁the ▁v acc ine . ▁ ▁Com ponents ▁and ▁mechanism ▁ ▁The ▁R TS , S ▁v acc ine ▁was ▁engine ered ▁using ▁gen es ▁from ▁the ▁repeat ▁and ▁T - cell ▁ep ito pe ▁in ▁the ▁pre - ery th ro cy t ic ▁circum sp or oz o ite ▁protein ▁( C SP ) ▁of ▁the ▁Pl as mod ium ▁fal ci par um ▁mal aria ▁par as ite ▁and ▁a ▁vir al ▁en velope ▁protein ▁of ▁the ▁he pat itis ▁B ▁virus ▁( H B s Ag ), ▁to ▁which ▁was ▁added ▁a ▁chemical ▁adj uv ant ▁( AS 0 1 ) ▁to ▁increase ▁the ▁imm une ▁system ▁response . ▁In fection ▁is ▁prevent ed ▁by ▁indu cing ▁hum oral ▁and ▁cell ular ▁imm unity , ▁with ▁high ▁ant ib ody ▁tit ers , ▁that ▁block ▁the ▁par as ite ▁from ▁inf ect ing ▁the ▁li ver . ▁ ▁The ▁T - cell ▁ep ito