▁my el ogen ous ▁le uk emia - ▁that ▁progress ed ▁to ▁' blast ▁crisis '. ▁ ▁Since ▁then , ▁increased ▁A X L ▁expression ▁has ▁been ▁associated ▁with ▁numerous ▁can cers ▁including ▁lung ▁cancer , ▁breast ▁cancer , ▁pan cre atic ▁cancer , ▁o var ian ▁cancer , ▁colon ▁cancer ▁and ▁mel an oma ▁among ▁others , ▁and ▁shown ▁to ▁have ▁a ▁ ▁strong ▁correlation ▁with ▁poor ▁surv ival ▁out comes . ▁ ▁A X L ▁has ▁been ▁shown ▁to ▁be ▁a ▁key ▁driver ▁of ▁drug - res istance ▁to ▁target ed ▁ther ap ies , ▁imm uno ▁ther ap ies ▁and ▁chem other apy ▁in ▁various ▁animal ▁models . ▁Based ▁on ▁current ▁knowledge ▁of ▁A X L ' s ▁role ▁in ▁ther apy ▁resistance , ▁future ▁studies ▁will ▁help ▁to ▁determine ▁whether ▁A X L ▁has ▁a ▁transl ational ▁application ▁as ▁a ▁bi om ark er ▁for ▁predict ing ▁th era pe ut ic ▁response ▁to ▁established ▁dru gs . ▁ ▁A X L ▁may ▁also ▁play ▁an ▁important ▁role ▁in ▁Z ika ▁virus ▁in fection , ▁allowing ▁for ▁entry ▁of ▁the ▁virus ▁into ▁host ▁cells . ▁ ▁As ▁a ▁drug ▁target ▁ ▁Studies ▁have ▁shown ▁that ▁A X L ▁knock down ▁leads ▁to ▁down reg ulation ▁of ▁trans cription ▁factors ▁required ▁for ▁E MT , ▁including ▁Sl ug , ▁Tw ist , ▁and ▁Z eb 1 , ▁and ▁to ▁increased ▁expression ▁of ▁E - c ad her in . ▁ ▁C lin ical ▁studies ▁ ▁Can cer ▁ ▁Several ▁dru