. ▁This ▁en zym e ▁catal y zes ▁the ▁reaction ▁which ▁converts ▁man n ose - 1 - ph osph ate ▁and ▁G TP ▁to ▁G DP - mann ose ▁which ▁is ▁involved ▁in ▁the ▁production ▁of ▁N - link ed ▁o lig os ac char ides . ▁The ▁gene ▁enc odes ▁two ▁trans cript ▁variants . ▁ ▁References ▁ ▁Further ▁reading <0x0A> </s> ▁Joseph ▁Howard ▁( 1 7 6 3 ▁– ▁ 5 ▁December ▁ 1 7 9 7 ▁in ▁Ber th ier ville ) ▁was ▁born ▁in ▁England ▁and ▁came ▁to ▁Montreal ▁in ▁ 1 7 6 0 . ▁He ▁became ▁one ▁of ▁the ▁first ▁English ▁mer ch ants ▁from ▁Montreal ▁to ▁enter ▁the ▁fur ▁trade , ▁an ▁enter prise ▁controlled ▁by ▁the ▁French ▁from ▁that ▁city ▁until ▁the ▁Seven ▁Years ' ▁War . ▁One ▁of ▁his ▁partners ▁was ▁George ▁All so pp ▁and ▁they ▁conducted ▁a ▁substantial ▁trade , ▁much ▁of ▁it ▁un lic ensed . ▁ ▁Biography ▁Joseph ▁Howard ▁arrived ▁in ▁Montreal ▁in ▁ 1 7 6 0 . ▁Starting ▁in ▁ 1 7 7 4 ▁and ▁throughout ▁the ▁ 1 7 7 0 s , ▁he ▁was ▁trad ing ▁f urs ▁at ▁Mich il im ack in ac . ▁In ▁August ▁ 1 7 7 5 , ▁he ▁purchased ▁lands ▁from ▁the ▁R ame z ay ▁property ▁on ▁the ▁Yam aska ▁River . ▁In ▁the ▁early ▁ 1 7 8 0 s , ▁after ▁being ▁refused ▁its ▁permit ▁to ▁produce ▁f urs ▁ 3 ▁years ▁in ▁a ▁row