▁as ▁well ▁as ▁repair ▁of ▁dam aged ▁areas . ▁The ▁process ▁is ▁triggered ▁by ▁decre ased ▁t issue ▁o xygen ▁( hy po x ia ) ▁or ▁ins u fficient ▁o xygen ▁t ension ▁leading ▁to ▁the ▁new ▁development ▁of ▁blood ▁vessels ▁l ined ▁with ▁end oth el ial ▁cells . ▁An gi ogen esis ▁is ▁reg ulated ▁by ▁signals ▁that ▁promote ▁and ▁decrease ▁the ▁process . ▁These ▁pro - ▁and ▁anti ang i ogen ic ▁signals ▁including ▁integr ins , ▁chem ok ines , ▁ang i opo iet ins , ▁o xygen ▁sens ing ▁agents , ▁j unction al ▁mole cules ▁and ▁end ogen ous ▁in hib itors . ▁An gi opo iet in - 2 ▁works ▁with ▁V EG F ▁to ▁facil itate ▁cell ▁pro l ifer ation ▁and ▁migration ▁of ▁end oth el ial ▁cells . ▁ ▁The ▁general ▁outline ▁of ▁ang i ogen esis ▁is ▁▁ ▁activ ating ▁signals ▁binding ▁to ▁surface ▁re cept ors ▁of ▁v asc ular ▁end oth el ial ▁cells . ▁ ▁activ ated ▁end oth el ial ▁cells ▁release ▁prote ases ▁leading ▁to ▁the ▁de grad ation ▁of ▁the ▁bas ement ▁memb rane ▁▁ ▁end oth el ial ▁cells ▁are ▁fre ed ▁to ▁migr ate ▁from ▁the ▁existing ▁blood ▁vessels ▁and ▁begin ▁to ▁pro l ifer ate ▁to ▁form ▁extensions ▁towards ▁the ▁source ▁of ▁the ▁ang i ogen ic ▁stim ulus . ▁ ▁C lin ical ▁significance ▁ ▁End oth el ial ▁d ys function , ▁or ▁the ▁loss ▁of ▁proper ▁end oth el