▁the ▁α - hel ices ▁of ▁the ▁z inc ▁fingers ▁interact ▁with ▁the ▁gu an ine - rich ▁region ▁of ▁the ▁DNA ▁double ▁hel ix ▁through ▁hydro gen ▁b onds ▁and ▁electro static ▁and ▁hydro ph ob ic ▁interactions . ▁The ▁spacing ▁of ▁the ▁resid ues ▁matches ▁the ▁spacing ▁of ▁the ▁base ▁pairs . ▁Z inc ▁fingers ▁fit ▁into ▁the ▁major ▁gro ove ▁and ▁wrap ▁around ▁the ▁DNA ▁hel ix ▁for ▁almost ▁one ▁turn . ▁ ▁Association ▁with ▁sch iz op hren ia ▁ ▁In ▁humans , ▁Z NF 8 0 4 A ▁is ▁expressed ▁broad ly ▁throughout ▁the ▁brain , ▁especially ▁in ▁the ▁developing ▁hi pp oc amp us ▁and ▁the ▁cor tex , ▁as ▁well ▁as ▁in ▁the ▁adult ▁c ere bell um . ▁Z NF 8 0 4 A ▁is ▁expected ▁to ▁bind ▁DNA ▁and ▁thus ▁reg ulate ▁gene ▁expression ▁like ▁other ▁z inc ▁finger ▁prote ins . ▁The ▁mouse ▁hom olog ue ▁of ▁Z NF 8 0 4 A , ▁z fp 8 0 4 a , ▁has ▁recently ▁been ▁reported ▁as ▁a ▁target ▁for ▁HO X C 8 , ▁suggesting ▁that ▁Z NF 8 0 4 A ▁may ▁be ▁involved ▁in ▁the ▁reg ulation ▁of ▁early ▁ne uro development . ▁ ▁A ▁Gen ome - wide ▁association ▁study ▁( G W AS ) ▁has ▁identified ▁Z NF 8 0 4 A ▁as ▁a ▁sus cept ibility ▁gene ▁for ▁sch iz op hren ia . ▁From ▁family , ▁tw in , ▁and ▁ad option ▁studies , ▁sch iz op