▁fusion ▁of ▁the ▁beta ▁and ▁alpha ▁sub un its ▁have ▁since ▁been ▁identified ▁in ▁several ▁e uk ary otic ▁super groups , ▁suggesting ▁that ▁such ▁nit rile ▁hyd rat ases ▁were ▁present ▁in ▁the ▁last ▁common ▁ancest or ▁of ▁all ▁e uk ary otes . ▁ ▁Indust rial ▁applications ▁N H ases ▁have ▁been ▁efficiently ▁used ▁for ▁the ▁industrial ▁production ▁of ▁ac ry lam ide ▁from ▁ac ry lon it rile ▁on ▁a ▁scale ▁of ▁ 6 0 0 ▁ 0 0 0 ▁tons ▁per ▁an num , ▁and ▁for ▁removal ▁of ▁nit ril es ▁from ▁waste water . ▁Ph otos ens itive ▁N H ases ▁intr ins ically ▁possess ▁nit ric ▁ox ide ▁( NO ) ▁bound ▁to ▁the ▁iron ▁centre , ▁and ▁its ▁phot od is soci ation ▁activ ates ▁the ▁en zym e . ▁Nic ot in am ide ▁is ▁produced ▁industri ally ▁by ▁the ▁hydro ly s is ▁of ▁ 3 - cy an opy rid ine ▁catal ys ed ▁by ▁the ▁nit rile ▁hyd rat ase ▁from ▁Rh od oc oc cus ▁rh od och r ous ▁J 1 , ▁producing ▁ 3 5 0 0 ▁tons ▁per ▁an num ▁of ▁nic ot in am ide ▁for ▁use ▁in ▁animal ▁feed . ▁ ▁Str ucture ▁ ▁N H ases ▁are ▁composed ▁of ▁two ▁types ▁of ▁sub un its , ▁α ▁and ▁ β , ▁which ▁are ▁not ▁related ▁in ▁am ino ▁acid ▁sequence . ▁N H ases ▁exist ▁as ▁α β ▁dim ers ▁or ▁α 2 β 2