▁gradient ▁in ▁X en opus ▁la e vis ▁gang l ion ▁cell ▁can ▁indu ce ▁turning ▁of ▁ret inal ▁growth ▁con es ▁in ▁vit ro ▁to ▁ste er ▁ax ons ▁out ▁of ▁the ▁ret ina . ▁Net rin ▁( unc - 6 , ▁Ca en or hab d itis ▁eleg ans ▁hom olog ue ) ▁and ▁its ▁corresponding ▁re ceptor ▁D CC ▁( De leted ▁in ▁Col ore ct al ▁Can cer ) ▁were ▁initially ▁identified ▁as ▁an ▁attract ive ▁interaction . ▁D CC , ▁expressed ▁by ▁comm iss ural ▁ax ons , ▁bind s ▁to ▁net rin ▁with ▁high ▁aff inity ; ▁in hib iting ▁net rin / D CC ▁signal ing ▁inter fer es ▁with ▁the ▁attract ive ▁turning ▁of ▁ret inal ▁growth ▁con es . ▁ ▁Net rin - 1 ▁has ▁also ▁been ▁shown ▁to ▁act ▁as ▁a ▁chem ore p ell ent ▁in ▁v ivo ▁for ▁tro ch lear ▁motor ▁ax ons ▁that ▁migr ate ▁d ors ally ▁away ▁from ▁the ▁floor ▁plate . ▁In ▁net rin - 1 ▁def ic ient ▁m ice , ▁tro ch lear ▁ax on ▁pro jections ▁are ▁normal , ▁suggesting ▁the ▁existence ▁of ▁other ▁redundant ▁guidance ▁c ues ▁working ▁in ▁tan dem ▁with ▁net rin - 1 ▁to ▁rep el ▁tro ch lear ▁ax ons . ▁ ▁Studies ▁in ▁C . ▁eleg ans ▁revealed ▁a ▁possible ▁mechanism ▁for ▁net rin ▁acting ▁as ▁a ▁chem ore p uls ive ▁agent ▁( Fig . 2 ). ▁Un c - 5 , ▁a ▁transm emb rane