▁hydro ph ob ic ▁hair pin ▁loop ▁of ▁tail ▁domain ▁is ▁imp a ired ▁by ▁the ▁negative ▁charges ▁of ▁the ▁ 6 8 - am ino ▁acid ▁insert , ▁thus ▁requiring ▁ph osph ol ip id - activ ated ▁regular ▁is o form ▁of ▁vin cul in ▁to ▁fully ▁activ ate ▁the ▁met av in cul in ▁mole c ule . ▁ ▁Inter actions ▁▁ ▁Vin cul in ▁has ▁been ▁shown ▁to ▁interact ▁with : ▁ ▁CD H 1 , ▁▁ ▁P ax ill in , ▁and ▁ ▁S OR BS 1 . ▁ ▁In ▁cases ▁of ▁Small ▁In test inal ▁B acter ial ▁Over g row th ▁presented ▁as ▁I BS ▁sympt oms , ▁anti - C dt B ▁ant ib od ies ▁have ▁been ▁identified ▁to ▁affect ▁vin cul in ▁function , ▁which ▁is ▁required ▁in ▁gut ▁mot ility . ▁ ▁References ▁ ▁Further ▁reading ▁ ▁External ▁links ▁▁▁▁▁▁ ▁Category : Per i pher al ▁memb rane ▁prote ins ▁Category : Cell ▁ad hes ion ▁prote ins <0x0A> </s> ▁Trad itional ▁metal ▁working ▁in ▁Mexico ▁dates ▁from ▁the ▁Mes o amer ican ▁period ▁with ▁met als ▁such ▁as ▁gold , ▁silver ▁and ▁co pper . ▁Other ▁met als ▁were ▁m ined ▁and ▁worked ▁starting ▁in ▁the ▁colonial ▁period . ▁The ▁working ▁of ▁gold ▁and ▁silver , ▁especially ▁for ▁j ew el ry , ▁initially ▁decl ined ▁after ▁the ▁Spanish ▁con quest ▁of ▁the ▁Az te c ▁Empire . ▁However , ▁during ▁the ▁colonial ▁period , ▁the ▁working ▁of ▁met als ▁rose