▁associated ▁with ▁severe ▁oc ular ▁to x icity , ▁which ▁pre cluded ▁its ▁use ▁in ▁human ▁patients . ▁D rug - indu ced ▁calcul i ▁( k id ney ▁stones ) ▁has ▁been ▁associated ▁with ▁such ▁ther apy ▁as ▁well . ▁An ap hy la ctic ▁shock ▁induced ▁by ▁fl um equ ine ▁ther apy ▁has ▁also ▁been ▁associated ▁with ▁its ▁use . ▁An ap hy la ct oid ▁re actions ▁such ▁as ▁shock , ▁u rt ic aria , ▁and ▁Qu in cke ’ s ▁o ed ema ▁have ▁been ▁reported ▁to ▁generally ▁appear ▁within ▁two ▁hours ▁after ▁taking ▁the ▁first ▁table t . ▁ ▁There ▁were ▁eigh teen ▁reports ▁listed ▁within ▁the ▁W HO ▁file ▁in ▁ 1 9 9 6 . ▁ ▁As ▁with ▁all ▁dru gs ▁within ▁this ▁class , ▁fl um equ ine ▁ther apy ▁may ▁result ▁in ▁severe ▁central ▁nerv ous ▁system ▁( C NS ) ▁re actions , ▁phot ot ox icity ▁resulting ▁in ▁skin ▁re actions ▁like ▁er yth ema , ▁pr ur it us , ▁u rt ic aria ▁and ▁severe ▁r ash es , ▁g astro int est inal ▁and ▁ne uro log ical ▁dis orders . ▁ ▁D rug ▁interactions ▁Fl um equ ine ▁was ▁found ▁to ▁have ▁no ▁effect ▁on ▁the oph yll ine ▁ph arm ac ok inet ics . ▁ ▁Chem istry ▁Fl um equ ine ▁is ▁a ▁ 9 - flu oro - 6 , 7 - d ih ydro - 5 - m eth yl - 1