R G 1 ) ▁expression . ▁ ▁N DR G 1 ▁is ▁a ▁met ast asis - supp ress or ▁gene ▁in ▁pro state ▁cancer , ▁and ▁appears ▁to ▁have ▁a ▁role ▁in ▁DNA ▁repair . ▁ ▁Screen ing ▁of ▁ 3 3 6 0 ▁comp ounds ▁revealed ▁that ▁ir in ot ec an - medi ated ▁T OP 1 ▁def ic iency ▁( and ▁one ▁other ▁comp ound , ▁cet rim on ium ▁b rom ide ) ▁exhib it ▁synth etic ▁le th ality ▁with ▁N DR G 1 ▁def ic iency ▁in ▁pro state ▁cancer ▁cells . ▁ ▁Inter actions ▁▁ ▁T OP 1 ▁has ▁been ▁shown ▁to ▁interact ▁with : ▁▁ ▁AS F / SF 2 , ▁▁ ▁B TB D 1 , ▁▁ ▁B TB D 2 , ▁▁ ▁N uc le olin , ▁▁ ▁P 5 3 , ▁ ▁and ▁ ▁U BE 2 I . ▁ ▁See ▁also ▁▁ ▁Type ▁I ▁to pois omer ase ▁ ▁Top ois omer ase ▁ ▁References ▁ ▁External ▁links <0x0A> </s> ▁Gregory ▁M . ▁Z anon ▁( born ▁June ▁ 5 , ▁ 1 9 8 0 ) ▁is ▁a ▁Canadian ▁former ▁professional ▁ice ▁hockey ▁def ens eman ▁who ▁played ▁almost ▁ 5 0 0 ▁games ▁in ▁the ▁National ▁Hockey ▁League ▁( N HL ). ▁ ▁Play ing ▁career ▁Greg ▁Z anon ▁was ▁draft ed ▁in ▁the ▁fifth ▁round , ▁ 1 5 6 th ▁overall , ▁in ▁the ▁ 2 0 0 0 ▁N HL ▁Entry ▁D raft ▁by ▁the