▁been ▁developed ▁to ▁treat ▁chron ic ▁my el oid ▁le uk emia ▁( C ML ), ▁in ▁which ▁the ▁B CR - AB L ▁fusion ▁gene ▁( the ▁product ▁of ▁a ▁reci pro cal ▁trans location ▁between ▁chrom os ome ▁ 9 ▁and ▁chrom os ome ▁ 2 2 ) ▁is ▁present ▁in ▁> 9 5 % ▁of ▁cases ▁and ▁produces ▁hyper activ ated ▁ab l - dri ven ▁protein ▁signal ing . ▁ ▁These ▁medic ations ▁specifically ▁in hib it ▁the ▁Ab les on ▁ty ros ine ▁kin ase ▁( AB L ) ▁protein ▁and ▁are ▁thus ▁a ▁prime ▁example ▁of ▁" r ational ▁drug ▁design " ▁based ▁on ▁knowledge ▁of ▁disease ▁path oph ys i ology . ▁ ▁The ▁Foundation One ▁CD x ▁report ▁produced ▁by ▁Foundation ▁Medicine , ▁which ▁looks ▁at ▁gen es ▁in ▁individual ▁patients ' ▁tum or ▁bi ops ies ▁and ▁recomm ends ▁specific ▁dru gs ▁ ▁High ▁mut ation ▁bur den ▁is ▁indic ative ▁of ▁response ▁to ▁imm un other apy , ▁and ▁also ▁specific ▁patterns ▁of ▁mut ations ▁have ▁been ▁associated ▁with ▁previous ▁expos ure ▁to ▁c yt ot ox ic ▁cancer ▁dru gs . ▁ ▁Population ▁screen ing ▁ ▁Gen om ics ▁can ▁be ▁used ▁to ▁identify ▁people ▁at ▁risk ▁for ▁disease , ▁which ▁can ▁assist ▁in ▁prevent ative ▁efforts . ▁Notable ▁examples ▁include : ▁▁ ▁the ▁My Code ® ▁Community ▁Health ▁In iti ative ▁by ▁Ge is inger ▁Health ▁System , ▁in ▁which ▁over ▁ 2 2 7 , 0 0 0 ▁patients ▁cons