une ▁responses ▁must ▁also ▁be ▁taken ▁into ▁account . ▁O ften ▁imm unos upp ression ▁is ▁required ▁with ▁these ▁gra ft s . ▁D ise ase ▁transmission ▁also ▁becomes ▁a ▁factor ▁when ▁introdu cing ▁t issue ▁from ▁another ▁person ▁or ▁animal . ▁Over all , ▁al log raft s ▁and ▁x en og raft s ▁do ▁not ▁match ▁the ▁quality ▁of ▁out comes ▁seen ▁with ▁aut og raft s , ▁but ▁they ▁are ▁necessary ▁when ▁there ▁is ▁a ▁lack ▁of ▁aut olog ous ▁n erve ▁t issue . ▁ ▁N erve ▁guidance ▁condu it ▁ ▁Because ▁of ▁the ▁limited ▁functionality ▁received ▁from ▁aut og raft s , ▁the ▁current ▁gold ▁standard ▁for ▁n erve ▁reg ener ation ▁and ▁repair , ▁recent ▁neural ▁t issue ▁engineering ▁research ▁has ▁focused ▁on ▁the ▁development ▁of ▁bio art ific ial ▁n erve ▁guidance ▁condu its ▁in ▁order ▁to ▁guide ▁ax onal ▁reg row th . ▁The ▁creation ▁of ▁artificial ▁n erve ▁condu its ▁is ▁also ▁known ▁as ▁ent ub ulation ▁because ▁the ▁n erve ▁ends ▁and ▁interven ing ▁gap ▁are ▁en closed ▁within ▁a ▁t ube ▁composed ▁of ▁bi ological ▁or ▁synth etic ▁materials . ▁ ▁Im mun isation ▁ ▁A ▁direction ▁of ▁research ▁is ▁towards ▁the ▁use ▁of ▁dru gs ▁that ▁target ▁rem y elin ating ▁in hib itor ▁prote ins , ▁or ▁other ▁in hib itors . ▁Possible ▁strateg ies ▁include ▁v acc ination ▁against ▁these ▁prote ins ▁( active ▁imm un isation ), ▁or ▁treatment ▁with ▁previously ▁created ▁ant ib od ies ▁( pass