▁lengths ▁of ▁din uc le ot ide ▁repe ats ▁of ▁the ▁nucle ob ases ▁c yt os ine ▁and ▁ad en ine ▁( sequence : ▁C AC AC AC AC A ... ). ▁ ▁The ▁ 4 ▁main ▁gen es ▁involved ▁in ▁H NP CC ▁normally ▁encode ▁for ▁prote ins ▁that ▁form ▁dim ers ▁to ▁function : ▁▁ ▁ML H 1 ▁protein ▁dim er izes ▁with ▁P MS 2 ▁protein ▁to ▁form ▁Mut L α , ▁which ▁coordinates ▁the ▁binding ▁of ▁other ▁prote ins ▁involved ▁with ▁mismatch ▁repair ▁like ▁DNA ▁hel ic ase , ▁single - str and ed - D NA ▁binding - prote in ▁( R PA ), ▁and ▁DNA ▁polym er ases . ▁ ▁M SH 2 ▁protein ▁dim er izes ▁with ▁M SH 6 ▁protein , ▁which ▁ident ifies ▁mismatch es ▁via ▁a ▁sl iding ▁cl amp ▁model , ▁a ▁protein ▁for ▁sc anning ▁for ▁errors . ▁ ▁The ▁imp air ment ▁of ▁either ▁gene ▁for ▁the ▁protein ▁dim er ▁imp airs ▁the ▁protein ▁function . ▁These ▁ 4 ▁gen es ▁are ▁involved ▁in ▁error ▁correction ▁( m ism atch ▁repair ), ▁so ▁d ys function ▁of ▁the ▁gen es ▁can ▁lead ▁to ▁the ▁in ability ▁to ▁fix ▁DNA ▁rep lication ▁errors ▁and ▁cause ▁H NP CC . ▁H NP CC ▁is ▁known ▁to ▁be ▁associated ▁with ▁other ▁mut ations ▁in ▁gen es ▁involved ▁in ▁the ▁DNA ▁mismatch ▁repair ▁path way : ▁ ▁People ▁with ▁M SH 6 ▁mut ations ▁are ▁more ▁likely ▁to ▁be ▁Amsterdam ▁criteria ▁II -