▁kinds ▁of ▁bi ote ch ▁indust ries , ▁such ▁as ▁ph arma ce ut ical ▁industry . ▁All ▁the ▁applications ▁are ▁based ▁on ▁its ▁feature ▁of ▁express ing ▁prote ins . ▁ ▁Bi other ape ut ic ▁production ▁In ▁the ▁last ▁few ▁years , ▁P ich ia ▁past oris ▁had ▁been ▁used ▁for ▁the ▁production ▁of ▁over ▁ 5 0 0 ▁types ▁of ▁bi other ape ut ics , ▁such ▁as ▁IF N γ . ▁At ▁the ▁beginning , ▁one ▁draw back ▁of ▁this ▁protein ▁expression ▁system ▁is ▁the ▁over - gly cos yl ation ▁with ▁high ▁density ▁of ▁man n ose ▁structure , ▁which ▁is ▁a ▁potential ▁cause ▁of ▁imm un ogen icity . ▁In ▁ 2 0 0 6 , ▁a ▁research ▁group ▁managed ▁to ▁create ▁a ▁new ▁stra in ▁called ▁Y SH 5 9 7 . ▁This ▁stra in ▁can ▁express ▁er yth ro po iet in ▁in ▁its ▁normal ▁g ly cos yl ation ▁form , ▁by ▁ex ch anging ▁the ▁en zym es ▁responsible ▁for ▁the ▁fung al ▁type ▁g ly cos yl ation , ▁with ▁the ▁m amm al ian ▁hom olog s . ▁Thus , ▁the ▁alter ed ▁g ly cos yl ation ▁pattern ▁allowed ▁the ▁protein ▁to ▁be ▁fully ▁functional . ▁ ▁En zym e ▁production ▁for ▁food ▁industry ▁In ▁food ▁indust ries , ▁like ▁bre wer y ▁and ▁b ake ▁house , P ich ia ▁past oris ▁is ▁used ▁to ▁produce ▁different ▁kinds ▁of ▁en zym es , ▁as ▁processing ▁a ids ▁and ▁food