▁mole c ule , ▁beyond ▁synth etic ▁ab ilities , ▁the ▁en anti omer ▁of ▁an ▁ep ito pe ▁is ▁produced . ▁ ▁SE LE X ▁Con vent ional ▁( up ▁to ▁ 1 0 1 6 ▁different ▁o lig on uc le ot ides ) ▁existing ▁mole c ule ▁library ▁serves ▁as ▁a ▁starting ▁point ▁for ▁the ▁subsequent ▁SE LE X ▁process . ▁Selection , ▁separation , ▁and ▁ampl ification ▁using ▁the ▁mirror ▁image ▁of ▁the ▁target ▁mole c ule ▁is ▁performed . ▁ ▁Se qu encing ▁and ▁synth esis ▁The ▁sequence ▁of ▁the ▁o lig on uc le ot ide ▁selected ▁using ▁SE LE X ▁is ▁determined ▁with ▁the ▁help ▁of ▁DNA ▁sequ encing . ▁This ▁information ▁is ▁used ▁for ▁the ▁synth esis ▁of ▁the ▁o lig on uc le ot ide ' s ▁en anti omer , ▁the ▁L - R NA ▁apt amer , ▁using ▁L - n uc le ot ides . ▁ ▁Use ▁L - R NA ▁apt am ers ▁have ▁been ▁obtained ▁for ▁the ▁chem ok ines ▁C CL 2 ▁and ▁C X CL 1 2 , ▁the ▁complement ▁components ▁C 5 a ▁and ▁g hre lin . ▁They ▁are ▁currently ▁in ▁pre cl in ical ▁or ▁clin ical ▁development . ▁Proof - of - con cept ▁for ▁an ▁anti - CC L 2 / M CP - 1 ▁L - R NA ▁apt am ers ▁has ▁recently ▁been ▁demonstrated ▁in ▁di ab etic ▁ne ph rop ath y ▁patients . ▁They ▁can ▁also ▁be ▁used