) ▁and ▁at ▁P HA CT R 1 ▁( rs 1 2 5 2 6 4 5 3 ) ▁showed ▁a ▁nomin ally ▁significant ▁association ▁with ▁coron ary ▁ar tery ▁calc ification ▁and ▁an ▁increased ▁degree ▁of ▁ar ter ial ▁calc ification . ▁ ▁C lin ical ▁Mark er ▁ ▁Additionally , ▁a ▁multi - loc us ▁gen etic ▁risk ▁score ▁study ▁based ▁on ▁a ▁combination ▁of ▁ 2 7 ▁lo ci , ▁including ▁the ▁P HA CT R 1 ▁gene , ▁identified ▁individuals ▁at ▁increased ▁risk ▁for ▁both ▁incident ▁and ▁rec urrent ▁coron ary ▁ar tery ▁disease ▁events , ▁as ▁well ▁as ▁an ▁en hanced ▁clin ical ▁benefit ▁from ▁stat in ▁ther apy . ▁The ▁study ▁was ▁based ▁on ▁a ▁community ▁coh ort ▁study ▁( the ▁Mal mo ▁Diet ▁and ▁Can cer ▁study ) ▁and ▁four ▁additional ▁random ized ▁controlled ▁tri als ▁of ▁primary ▁prevent ion ▁coh ort s ▁( J UP IT ER ▁and ▁ASC OT ) ▁and ▁secondary ▁prevent ion ▁coh ort s ▁( CA RE ▁and ▁PRO VE ▁IT - T IM I ▁ 2 2 ). ▁ ▁Another ▁gen ome - wide ▁association ▁study ▁in ▁ 2 , 3 2 6 ▁clin ic - based ▁German ▁and ▁Dutch ▁individuals ▁with ▁mig raine ▁without ▁a ura ▁identified ▁that ▁P HA CT R 1 ▁( t ogether ▁with ▁A ST N 2 ) ▁as ▁sus cept ibility ▁lo ci ▁for ▁mig raine ▁without ▁a ura , ▁thereby ▁expand ing ▁our ▁knowledge ▁of ▁this ▁deb il it ating ▁ne uro log