hren ia ▁is ▁found ▁to ▁have ▁her it ability ▁of ▁~ 8 0 % ▁and ▁it ▁is ▁sus pected ▁that ▁risk ▁results ▁from ▁multiple ▁gen etic ▁variants ▁of ▁small ▁effect . ▁The ▁single - n uc le ot ide ▁polym orphism ▁( SN P ) ▁rs 1 3 4 4 7 0 6 ▁in ▁intr on ▁ 2 ▁of ▁Z NF 8 0 4 A ▁has ▁been ▁identified ▁as ▁a ▁variant ▁that ▁is ▁most ▁strongly ▁associated ▁with ▁sch iz op hren ia . ▁ ▁The ▁same ▁SN P ▁has ▁been ▁reported ▁to ▁correlate ▁with ▁slightly ▁dist urbed ▁functional ▁coupling ▁of ▁several ▁brain ▁regions ▁in ▁health y ▁persons , ▁res emb ling ▁the ▁changes ▁described ▁in ▁sch iz op hren ia . ▁A ▁further ▁study ▁revealed ▁that ▁the ▁SN P ▁rs 1 3 4 4 7 0 6 ▁was ▁consistent ▁with ▁sch iz op hren ia ▁association ▁in ▁European ▁patients , ▁but ▁not ▁in ▁Han ▁Chinese ▁patients . ▁Moreover , ▁the ▁study ▁showed ▁that ▁SN P s ▁rs 1 0 2 1 0 4 2 ▁and ▁rs 3 5 9 8 9 5 ▁are ▁associated ▁with ▁sch iz op hren ia ▁in ▁Han ▁Chinese ▁patients , ▁and ▁that ▁the ▁rs 3 5 9 8 9 5 ▁alle le ▁increases ▁the ▁prom oter ▁activity ▁of ▁Z NF 8 0 4 A . ▁The ▁results ▁of ▁another ▁study ▁suggest ▁that ▁there ▁is ▁no ▁relationship ▁between ▁variant ▁rs 1 3 4 4 7 0 6 ▁and ▁imp a ired ▁cogn itive ▁function ▁in ▁sch iz op hren