- c aten in ▁nuclear ▁accum ulation ▁is ▁via ▁the ▁in hib ition ▁of ▁g ale ct in - 3 . ▁The ▁g ale ct in - 3 ▁in hib itor ▁GR - MD - 0 2 ▁is ▁currently ▁under going ▁clin ical ▁tri als ▁in ▁combination ▁with ▁the ▁F DA - appro ved ▁do se ▁of ▁ip il imum ab ▁in ▁patients ▁who ▁have ▁advanced ▁mel an oma . ▁ ▁Ro le ▁in ▁f etal ▁alco hol ▁synd rome ▁ β - c aten in ▁dest abil ization ▁by ▁eth an ol ▁is ▁one ▁of ▁two ▁known ▁path ways ▁where by ▁alco hol ▁expos ure ▁indu ces ▁f etal ▁alco hol ▁synd rome ▁( the ▁other ▁is ▁eth an ol - indu ced ▁fol ate ▁def ic iency ). ▁Eth an ol ▁leads ▁to ▁ β - c aten in ▁dest abil ization ▁via ▁a ▁G - prote in - dependent ▁path way , ▁where in ▁activ ated ▁Ph osph ol ip ase ▁C β ▁hydro ly zes ▁ph osph at id y lin os it ol -( 4 , 5 )- bis ph osph ate ▁to ▁dia cy l gly cer ol ▁and ▁in os it ol -( 1 , 4 , 5 )- tr is ph osph ate . ▁Sol ub le ▁in os it ol -( 1 , 4 , 5 )- tr is ph osph ate ▁triggers ▁calci um ▁to ▁be ▁released ▁from ▁the ▁end op las mic ▁ret icul um . ▁This ▁sudden ▁increase ▁in ▁cy top