▁micro scale ▁magnetic ▁structures ▁are ▁implemented ▁to ▁provide ▁better ▁control ▁of ▁the ▁magnetic ▁field ▁and ▁assist ▁the ▁C TC s ▁detection . ▁On col yt ic ▁vir uses ▁such ▁as ▁v acc in ia ▁vir uses ▁are ▁developed ▁to ▁detect ▁and ▁identify ▁C TC s . ▁Altern ative ▁methods ▁exist ▁which ▁use ▁engine ered ▁prote ins ▁instead ▁of ▁ant ib od ies , ▁such ▁as ▁the ▁mal aria ▁V AR 2 C SA ▁protein , ▁which ▁bind s ▁to ▁on c of etal ▁ch ond roit in ▁sul f ate ▁on ▁the ▁surface ▁of ▁C TC s . ▁C TC s ▁may ▁also ▁be ▁retrieved ▁directly ▁from ▁the ▁blood ▁by ▁a ▁modified ▁S eld inger ▁technique , ▁as ▁developed ▁by ▁G IL U PI ▁GmbH . ▁An ▁ant ib ody ▁co ated ▁metal ▁wire ▁is ▁inserted ▁into ▁a ▁peri pher al ▁ve in ▁and ▁stays ▁there ▁for ▁a ▁defined ▁period ▁( 3 0 ▁min ). ▁During ▁this ▁time , ▁C TC s ▁from ▁the ▁blood ▁can ▁bind ▁to ▁the ▁ant ib od ies ▁( current ly ▁anti - E p C AM ). ▁After ▁the ▁inc ub ation ▁time , ▁the ▁wire ▁is ▁removed , ▁was hed ▁and ▁the ▁native ▁C TC s , ▁isolated ▁from ▁the ▁blood ▁of ▁the ▁patient , ▁can ▁be ▁further ▁anal ys ed . ▁M ole cular ▁gen et ics ▁as ▁well ▁as ▁imm un of lu ores cent ▁st aining ▁and ▁several ▁other ▁methods ▁are ▁possible . ▁Adv antage ▁of ▁this ▁method ▁is ▁the ▁higher ▁blood ▁volume