▁ 2 3 - 4 4 %, ▁or ▁ 0 - 1 2 % ▁of ▁cases , ▁respectively . ▁Similar ▁to ▁B ▁cell ▁le uk em ias , ▁but ▁unlike ▁multiple ▁my el oma , ▁p P CL ▁patients ▁exhib it ▁relative ▁high ▁frequencies ▁of ▁spl en om eg aly , ▁l ym ph aden op ath y , ▁he pat om eg aly , ▁kid ney ▁failure , ▁b one ▁mar row ▁failure ▁( i . e . ▁th rom b oc yt open ia , ▁an emia , ▁and / or , ▁rarely , ▁le uk open ia ), ▁central ▁nerv ous ▁system ▁defect s , ▁and ▁peri pher al ▁ne urop ath ies ▁due ▁to ▁the ▁invasion ▁of ▁these ▁t issues ▁by ▁pl asma ▁cells ▁and / or ▁the ▁de position ▁of ▁their ▁circul ating ▁mon oc l onal ▁imm un og lob ul in ▁in ▁them . ▁Comp ared ▁to ▁multiple ▁my el oma ▁patients , ▁p P CL ▁patients ▁also : ▁exhib it ▁ 1 ) ▁high ▁rates ▁of ▁developing ▁a ▁hyper cal cem ic ▁crisis , ▁i . e . ▁a ▁potentially ▁life - th re aten ing ▁episode ▁of ▁high ▁ion ic ▁calci um ▁( Ca 2 +) ▁levels ▁in ▁the ▁blood ▁due ▁to ▁excess ▁b one ▁re - abs or ption ▁and / or ▁ren al ▁failure ; ▁b ) ▁ ▁higher ▁levels ▁of ▁ser um ▁la ct ate ▁de h ydro gen ase ▁and ▁B eta - 2 ▁micro glob ul in ; ▁and