NA ▁into ▁DNA . ▁Un like ▁nucle os ide ▁R T Is , ▁which ▁bind ▁at ▁the ▁polym er ase ▁active ▁site , ▁N N RT Is ▁bind ▁to ▁a ▁hydro ph ob ic ▁pocket ▁in ▁the ▁sub domain ▁of ▁p 6 6 ▁which ▁is ▁about ▁ 1 0 ▁ang st rom ▁away ▁from ▁the ▁active ▁site ▁( known ▁as ▁the ▁N N RT I ▁pocket ). ▁Therefore , ▁this ▁N N RT I - binding ▁pocket ▁will ▁in hib it ▁reverse ▁trans cription ▁in ▁a ▁way ▁that ▁is ▁distinct ▁to ▁the ▁N RT Is . ▁ ▁Ne vi rap ine ▁is ▁not ▁effective ▁against ▁H IV - 2 , ▁as ▁the ▁pocket ▁of ▁the ▁H IV - 2 ▁reverse ▁trans cript ase ▁has ▁a ▁different ▁structure , ▁which ▁conf ers ▁intr insic ▁resistance ▁to ▁the ▁N N RT I ▁class . ▁ ▁Res istance ▁to ▁ne vi rap ine ▁develop s ▁rapidly ▁if ▁vir al ▁rep lication ▁is ▁not ▁completely ▁suppress ed . ▁The ▁most ▁common ▁mut ations ▁observed ▁after ▁ne vi rap ine ▁treatment ▁are ▁Y 1 8 1 C ▁and ▁K 1 0 3 N , ▁which ▁are ▁also ▁observed ▁with ▁other ▁N N RT Is . ▁As ▁all ▁N N RT Is ▁bind ▁within ▁the ▁same ▁pocket , ▁vir al ▁stra ins ▁which ▁are ▁resist ant ▁to ▁ne vi rap ine ▁are ▁usually ▁also ▁resist ant ▁to ▁the ▁other ▁N N RT Is , ▁e f av ir enz ▁and ▁del av ird ine . ▁However , ▁second ▁generation