▁in ▁tre ating ▁b ip olar ▁dis order , ▁it ▁is ▁extremely ▁to xic ▁metal ▁and ▁the ▁to xic ▁do se ▁is ▁only ▁margin ally ▁greater ▁than ▁the ▁th era pe ut ic ▁do se . ▁ ▁A ▁novel ▁in hib itor ▁of ▁I MP ase ▁that ▁is ▁less ▁to xic ▁could ▁be ▁a ▁more ▁des irable ▁treatment ▁for ▁b ip olar ▁dis order . ▁Such ▁an ▁in hib itor ▁would ▁need ▁to ▁cross ▁the ▁blood – bra in ▁bar rier ▁in ▁order ▁to ▁reach ▁the ▁I MP ase ▁in ▁neur ons . ▁ ▁References ▁ ▁Further ▁reading ▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁ ▁▁▁▁▁▁▁▁ ▁C ock cro ft , ▁S . ▁( Ed .), ▁Bi ology ▁of ▁Ph osph o inos it ides , ▁Bi ology ▁of ▁Ph osph o inos it ides , ▁Oxford , ▁ 2 0 0 0 , ▁p .   3 2 0 - 3 3 8 . ▁▁▁ ▁Category : M ood ▁dis orders ▁Category : Bi ology ▁of ▁b ip olar ▁dis order ▁Category : EC ▁ 3 . 1 . 3 ▁Category : En zym es ▁of ▁known ▁structure <0x0A> </s> ▁Abd ul me j id ▁II ▁( , ▁, ▁ 2 9 ▁May ▁ 1 8 6 8 ▁– ▁ 2 3 ▁August ▁ 1 9 4 4 ) ▁was ▁the ▁last ▁C ali ph ▁of ▁Ott oman ▁D ynast y , ▁nomin ally ▁the ▁ 3 7 th ▁Head ▁of ▁the ▁Ott oman ▁Imperial ▁House ▁from ▁ 1 9 2 2 ▁to ▁ 1 9 2 4