▁be ▁used ▁to ▁detect ▁ab normal ▁mismatch ▁repair ▁( MM R ) ▁protein ▁expression ▁in ▁tum ours ▁that ▁are ▁associated ▁with ▁Lyn ch ▁synd rome . ▁While ▁it ▁is ▁not ▁di agnostic ▁of ▁a ▁Lyn ch ▁synd rome , ▁it ▁can ▁play ▁a ▁role ▁in ▁ident ifying ▁people ▁who ▁should ▁have ▁ger ml ine ▁testing . ▁Two ▁methods ▁of ▁implementation ▁of ▁I HC ▁testing ▁includes ▁age - based ▁testing ▁and ▁universal ▁testing ▁for ▁all ▁people . ▁Currently , ▁there ▁is ▁no ▁w ides p read ▁agreement ▁regarding ▁which ▁screen ing ▁method ▁should ▁be ▁used . ▁Age - based ▁testing ▁for ▁I HC ▁has ▁been ▁suggested ▁in ▁part ▁due ▁to ▁cost - ben ef it ▁anal ys es , ▁whereas ▁universal ▁testing ▁for ▁all ▁people ▁with ▁col ore ct al ▁cancer ▁ens ures ▁people ▁with ▁Lyn ch ▁Sy nd rome ▁are ▁not ▁missed . ▁ ▁Mic ros at ellite ▁Inst ability ▁ ▁Mut ations ▁in ▁DNA ▁mismatch ▁repair ▁systems ▁can ▁lead ▁to ▁difficulty ▁transm itting ▁regions ▁within ▁the ▁DNA ▁which ▁contain ▁repeating ▁patterns ▁of ▁two ▁or ▁three ▁nucle ot ides ▁( mic ros at ell ites ), ▁otherwise ▁known ▁as ▁mic ros at ellite ▁inst ability ▁( MS I ). ▁M SI ▁is ▁identified ▁through ▁DNA ▁extra ction ▁from ▁both ▁a ▁tum or ▁t issue ▁sample ▁and ▁a ▁normal ▁t issue ▁sample ▁followed ▁by ▁PC R ▁analysis ▁of ▁mic ros at ellite ▁regions . ▁M SI ▁analysis ▁can ▁be ▁used ▁to ▁identify ▁people ▁who ▁may ▁have ▁Lyn ch ▁synd rome ▁and ▁direct ▁them ▁for