▁hyd rog ens ▁from ▁the ▁main ▁chain ▁am ide ▁groups ▁of ▁P he - 7 2 1 ▁and ▁L ys - 7 2 2 ▁in ▁p R b . ▁The ▁mut ation ▁of ▁G lu - 1 0 7 ▁to ▁L ys - 1 0 7 ▁is ▁expected ▁to ▁result ▁in ▁loss ▁of ▁these ▁hydro gen ▁b onds . ▁Furthermore , ▁the ▁side ▁chain ▁of ▁L ys - 1 0 7 ▁would ▁likely ▁have ▁ener get ically ▁unf avor able ▁interactions ▁with ▁the ▁am ide ▁of ▁P he - 7 2 1 ▁or ▁L ys - 7 2 2 , ▁dest abil izing ▁the ▁complex . ▁ ▁Str ong ▁experimental ▁evidence ▁confir ms ▁that ▁posit ively ▁charged ▁am ino ▁ac ids ▁( L ys ▁or ▁Arg ) ▁significantly ▁weak en ▁the ▁binding ▁interaction ▁with ▁p R B ▁when ▁position ed ▁in ▁the ▁vic inity ▁of ▁the ▁Le u ▁– ▁x ▁– ▁C ys ▁– ▁x ▁– ▁G lu ▁sequence . ▁ ▁This ▁is ▁likely ▁due ▁to ▁the ▁fact ▁that ▁the ▁binding ▁surface ▁on ▁p R b ▁features ▁six ▁l ys ine ▁resid ues , ▁which ▁will ▁tend ▁to ▁rep el ▁positive ▁resid ues ▁within ▁or ▁fl ank ing ▁the ▁Le u ▁– ▁x ▁– ▁C ys ▁– ▁x ▁– ▁G lu ▁sequence . ▁ ▁References ▁ ▁Category : V iral ▁prote ins ▁Category : Pol y om av ir idae <0x0A> </s> ▁Sa ib ai ▁Island ▁is ▁an ▁island ▁of ▁the ▁Tor res ▁Stra it ▁Islands ▁arch ip el ago , ▁located ▁in