▁seen ▁as ▁a ▁negative ▁factor ▁in ▁pot enti ating ▁the ▁ability ▁of ▁cancer ous ▁cells ▁to ▁extend ▁their ▁blood ▁supply ▁and ▁thereby ▁enable ▁further ▁cell ▁pro l ifer ation . ▁ ▁Pe pt ide ▁▁ ▁Ad ren omed ull in ▁consists ▁of ▁ 5 2 ▁am ino ▁ac ids , ▁has ▁ 1 ▁intr am ole cular ▁dis ulf ide ▁bond , ▁and ▁shows ▁a ▁slight ▁hom ology ▁with ▁the ▁cal cit on in ▁gene - related ▁pe pt ide ▁( CG R P ). ▁The ▁prec ursor , ▁called ▁pre pro ad ren omed ull in , ▁consists ▁of ▁ 1 8 5 ▁am ino ▁ac ids ▁and ▁can ▁be ▁cle aved ▁by ▁pl asma ▁kal li kre in ▁at ▁the ▁L ys - Arg ▁and ▁Arg - Arg ▁sites . ▁By ▁R NA - bl ot ▁analysis , ▁human ▁ad ren omed ull in ▁m R NA ▁was ▁found ▁to ▁be ▁expressed ▁in ▁all ▁t issues , ▁and ▁most ▁highly ▁expressed ▁in ▁the ▁pla cent a , ▁fat ▁cells , ▁lung , ▁pan cre atic ▁is lets , ▁smooth ▁mus cle , ▁and ▁skin . ▁ ▁The ▁human ▁AM ▁gene ▁is ▁local ized ▁to ▁a ▁single ▁loc us ▁on ▁Ch rom os ome ▁ 1 1 ▁with ▁ 4 ▁ex ons ▁and ▁ 3 ▁intr ons . ▁ ▁The ▁AM ▁gene ▁initially ▁codes ▁for ▁a ▁ 1 8 5 - am ino ▁acid ▁prec ursor ▁pe pt ide , ▁that ▁can ▁be ▁differential ly ▁exc ised ▁to ▁form ▁a ▁number ▁of