2 1 st - century ▁American ▁non - f iction ▁writers ▁Category : 2 0 th - century ▁American ▁male ▁writers ▁Category : C NN ▁people <0x0A> </s> ▁Filip in ▁is ▁a ▁mixture ▁of ▁chemical ▁comp ounds ▁first ▁isolated ▁by ▁chem ists ▁at ▁the ▁Up j ohn ▁company ▁in ▁ 1 9 5 5 ▁from ▁the ▁my cel ium ▁and ▁culture ▁fil tr ates ▁of ▁a ▁previously ▁unknown ▁act in om yc ete , ▁Stre pt omy ces ▁fil ip in ensis . ▁ ▁It ▁was ▁discovered ▁in ▁a ▁soil ▁sample ▁collected ▁in ▁the ▁Philipp ine ▁Islands , ▁hence ▁the ▁name ▁fil ip in . ▁ ▁The ▁isol ate ▁possessed ▁pot ent ▁ant if ung al ▁activity . ▁It ▁was ▁identified ▁as ▁a ▁poly ene ▁macro lide ▁based ▁on ▁its ▁characteristic ▁U V - Vis ▁and ▁IR ▁spect ra . ▁ ▁Function s ▁Although ▁the ▁poly ene ▁macro lide ▁ant ib iot ics ▁exhib it ▁pot ent ▁ant if ung al ▁activity , ▁most ▁are ▁too ▁to xic ▁for ▁th era pe ut ic ▁applications , ▁with ▁the ▁exceptions ▁of ▁am ph oter ic in ▁B ▁and ▁n yst atin ▁A 1 . ▁ ▁Un like ▁am ph oter ic in ▁B ▁and ▁n yst atin ▁A 1 ▁which ▁form ▁ster ol - dependent ▁ion ▁channels , ▁fil ip in ▁is ▁thought ▁to ▁be ▁a ▁simple ▁memb rane ▁dis rup ter . ▁ ▁Since ▁fil ip in ▁is ▁highly ▁flu ores cent ▁and ▁bind s ▁specifically ▁to ▁ch ol ester ol , ▁it