▁t issues ▁with ▁slower ▁turn over ▁rate ▁like ▁the ▁li ver ▁are ▁less ▁sus cept ible . ▁ ▁Ex pos ure ▁to ▁ben zo [ c ] flu or ene ▁in ▁v ivo ▁leads ▁to ▁the ▁induction ▁of ▁mainly ▁lung ▁tum ors ▁where ▁it ▁acts ▁as ▁a ▁DNA ▁ad duct or . ▁L ung ▁tum ors ▁arise ▁after ▁top ical ▁application ▁in ▁m ice ▁with ▁coal ▁tar , ▁but ▁also ▁when ▁it ▁is ▁ing ested . ▁Next ▁to ▁its ▁invol vement ▁in ▁lung ▁tum ors , ▁ben zo [ c ] flu or ene ▁and ▁its ▁met abol ites ▁are ▁expected ▁to ▁be ▁involved ▁in ▁the ▁formation ▁of ▁different ▁tum ors . ▁The ▁formation ▁of ▁DNA ▁ad duct s ▁in ▁human ▁breast ▁tum ors , ▁he pat oma ▁and ▁colon ▁ad en oc arc in oma ▁by ▁these ▁met abol ites ▁has ▁been ▁shown ▁in ▁vit ro . ▁These ▁ad duct s ▁and ▁the ▁ones ▁that ▁were ▁observed ▁in ▁lung ▁tum ors ▁of ▁m ice ▁were ▁similar , ▁which ▁strength ens ▁the ▁hypothesis ▁that ▁human ▁cells ▁are ▁capable ▁of ▁forming ▁the ▁mut agen ic ▁met abol ites . ▁ ▁Environment al ▁expos ure ▁Ben zo [ c ] flu or ene ▁belongs ▁to ▁a ▁group ▁of ▁comp ounds ▁called ▁poly cyc lic ▁a rom atic ▁hydro car b ons ▁( PA H s ). ▁PA H s ▁and ▁their ▁derivatives ▁are ▁u bi quit ous ▁in ▁the ▁environment ▁and ▁they ▁are ▁produced ▁in ▁several ▁industrial ▁and ▁comb ust ion ▁processes . ▁ ▁Work