▁( U GA U GA ) ▁and ▁the ▁D ▁box ▁( C U GA ). ▁Most ▁of ▁the ▁members ▁of ▁the ▁box ▁C / D ▁family ▁function ▁in ▁direct ing ▁site - specific ▁ 2 '- O - m eth yl ation ▁of ▁substr ate ▁R N As . ▁ ▁U 4 6 ▁is ▁encoded ▁in ▁intr on ▁ 2 ▁of ▁the ▁rib os om al ▁protein ▁S 8 ▁gene ▁in ▁human , ▁and ▁is ▁hypoth es ised ▁to ▁guide ▁m eth yl ation ▁of ▁ 2 '- O - ri bose ▁resid ues ▁on ▁ 2 8 S ▁rib os om al ▁R NA ▁( r R NA ). ▁The ▁hom olog ue ▁of ▁this ▁s no R NA ▁in ▁Arab id opsis ▁th al iana ▁is ▁called ▁s no Z 1 5 3 . ▁Some ▁human ▁U 4 0 ▁sequences ▁have ▁been ▁annot ated ▁in ▁the ▁sequence ▁databases ▁( Gen bank ) ▁as ▁U 4 6 . ▁ ▁References ▁ ▁External ▁links ▁▁▁▁▁▁ ▁Category : Sm all ▁nuclear ▁R NA <0x0A> </s> ▁Big amy ▁is ▁the ▁act ▁of ▁entering ▁into ▁a ▁marriage ▁with ▁one ▁person ▁while ▁still ▁leg ally ▁married ▁to ▁another . ▁ ▁Big amy ▁may ▁also ▁refer ▁to : ▁ ▁Big amy ▁( can on ▁law ) ▁ ▁Big amy ▁( 1 9 2 2 ▁film ), ▁a ▁German ▁silent ▁drama ▁film ▁ ▁Big amy ▁( 1 9 2 7 ▁film ), ▁a ▁German ▁silent ▁drama ▁film ▁ ▁Operation ▁Big amy , ▁a ▁ra id ▁during ▁the ▁Second ▁World