5   m g / kg ▁over ▁ 4 0 ▁minutes , ▁and ▁if ▁the ▁patients ▁respond ▁satisf actory , ▁as ▁de emed ▁by ▁the ▁investig ators , ▁then ▁they ▁will ▁be ▁admin ister ed ▁a ▁do se ▁Cy cl ur ad ▁or ▁to ▁a ▁compar ator ▁group . ▁This ▁clin ical ▁trial ▁is ▁in ▁part ▁supported ▁by ▁a ▁letter ▁the ▁editor ▁in ▁the ▁Journal ▁of ▁C lin ical ▁Psych iat ry , ▁where ▁patients ▁received ▁an ▁ac ute ▁do se ▁of ▁k et am ine , ▁followed ▁by ▁daily ▁D - cy clos er ine . ▁Pat ients ▁appeared ▁to ▁show ▁a ▁decrease ▁in ▁de pression ▁scores , ▁based ▁Hamilton ▁De pression ▁R ating ▁Sc ale ▁and ▁Beck ▁De pression ▁In ventory , ▁in ▁the ▁treatment ▁arm . ▁Al ong ▁with ▁this ▁letter , ▁D - cy clos er ine ▁was ▁also ▁used ▁in ▁a ▁similar ▁scenario ▁with ▁treatment ▁resist ant ▁de pression . ▁In ▁this ▁trial , ▁patients ▁were ▁admin ister ed ▁either ▁D - cy clos er ine ▁or ▁a ▁place bo . ▁The ▁main ▁significance ▁of ▁this ▁trial ▁were ▁not ▁just ▁the ▁results ▁from ▁the ▁treatment , ▁but ▁the ▁fact ▁that ▁D - cy clos er ine , ▁which ▁is ▁an ▁N MD A ▁ant agon ist , ▁has ▁potential ▁th era pe ut ic ▁role ▁in ▁tre ating ▁de pression . ▁ ▁See ▁also ▁ ▁List ▁of ▁investig ational ▁ant ide press ants ▁ ▁References ▁ ▁External ▁links ▁ ▁Cy clos er ine / l uras id one