▁terminal ▁R GS - hom ology ▁( R H ) ▁domain ▁of ▁GR K 2 ▁and ▁GR K 3 ▁bind s ▁to ▁heter otr imer ic ▁G ▁protein ▁sub un its ▁of ▁the ▁G q ▁family ▁to ▁reduce ▁G q ▁signal ing ▁by ▁se quest ering ▁active ▁G ▁prote ins ▁away ▁from ▁their ▁effect or ▁prote ins ▁such ▁as ▁ph osph ol ip ase ▁C - beta ; ▁but ▁the ▁GR K 2 ▁and ▁GR K 3 ▁R H ▁domains ▁are ▁unable ▁to ▁function ▁as ▁G TP ase - activ ating ▁prote ins ▁( as ▁do ▁traditional ▁R GS ▁prote ins ) ▁to ▁turn ▁off ▁G ▁protein ▁signal ing . ▁ ▁Inter actions ▁▁ ▁GR K 2 ▁has ▁been ▁shown ▁to ▁interact ▁with ▁numerous ▁protein ▁partners , ▁including : ▁▁ ▁G ▁protein ▁ β γ ▁complex ▁ ▁G ▁protein ▁G NA Q ▁family ▁members ▁ ▁G IT 1 ▁and ▁G IT 2 ▁ ▁P DE 6 G ▁ ▁PR K CB 1 ▁ ▁S rc ▁ ▁See ▁also ▁▁ ▁G ▁protein - cou ple d ▁re ceptor ▁kin ases ▁ ▁G ▁protein ▁ ▁des ens it ization ▁( med ic ine ) ▁ ▁arrest in ▁ ▁Kin ase ▁ ▁References ▁ ▁External ▁links ▁ ▁Category : Pro te ins ▁Category : EC ▁ 2 . 7 . 1 1 ▁Category : Trans fer ases ▁Category : Pro te in ▁kin ases <0x0A> </s> ▁De us ▁Ex ▁Mach ina ▁( band ) ▁is ▁an ▁Italian ▁progress ive ▁rock ▁group . ▁M embers ▁include ▁Cla