▁in ▁system ic ▁l up us ▁er yth em atos us ▁diagn osis ▁The ▁k inet op last ▁found ▁in ▁C . ▁luc ilia e ▁allows ▁them ▁to ▁be ▁used ▁for ▁the ▁detection ▁of ▁anti - ds D NA ▁ant ib od ies , ▁a ▁type ▁of ▁anti - n uc lear ▁ant ib ody . ▁Anti - n uc lear ▁ant ib od ies ▁are ▁a ▁common ▁feature ▁in ▁S LE , ▁and ▁anti - ds D NA ▁ant ib od ies ▁are ▁highly ▁specific ▁for ▁the ▁disease . ▁The ▁high ▁concentration ▁of ▁ds D NA ▁and ▁the ▁absence ▁of ▁human ▁nuclear ▁ant ig ens ▁in ▁the ▁k inet op last ▁provides ▁a ▁specific ▁substr ate ▁for ▁the ▁detection ▁of ▁anti - ds D NA ▁ant ib od ies . ▁▁ ▁Pur ine ▁nucle ot ide ▁and ▁nucle ob ase ▁u pt ake ▁ ▁As ▁a ▁par as it ic ▁proto zo an , ▁C . ▁luc ilia e '' ▁la cks ▁the ▁ability ▁to ▁b ios yn th et ically ▁produce ▁pur ine ▁bases ▁and ▁therefore ▁needs ▁to ▁salv age ▁them ▁from ▁the ▁surrounding ▁environment . ▁Three ▁transport ▁systems ▁are ▁used ▁for ▁the ▁u pt ake ▁of ▁bases ▁from ▁the ▁host ▁organ ism : ▁one ▁for ▁the ▁u pt ake ▁of ▁ad en os ine ▁and ▁its ▁analog ues ; ▁one ▁for ▁gu anos ine , ▁its ▁analog ues ▁and ▁in os ine ; ▁and ▁one ▁for ▁hy po x anth ine , ▁ad en ine ▁and ▁ad en os ine