▁this ▁virus ▁usually ▁occurs ▁near ▁the ▁nucle us ▁once ▁it ▁inf ect s ▁the ▁am o eb a . ▁Once ▁the ▁virus ▁inf ect s ▁it ▁can ▁cause ▁a ▁shape ▁change ▁in ▁the ▁host ’ s ▁nucle us . ▁ ▁Meg av ir idae ▁The ▁Meg av ir idae ▁contains ▁some ▁of ▁the ▁largest ▁vir uses ▁ever ▁discovered . ▁They ▁have ▁linear ▁double ▁str and ed ▁DNA ▁genom es ▁with ▁the ▁length ▁of ▁ 1 , 2 5 9 , 1 9 7 ▁base ▁pairs , ▁which ▁is ▁larger ▁than ▁some ▁small ▁b acter ia . ▁Within ▁in ▁this ▁gen ome ▁ 1 , 1 0 0 ▁prote ins ▁are ▁c oded . ▁ 7 4 . 7 6 % ▁of ▁the ▁base ▁pairs ▁are ▁represented ▁by ▁th ym ine ▁and ▁ad en ine . ▁The ▁Meg av ir idae ▁virus ▁can ▁be ▁found ▁inf ect ing ▁ac anth amo eb a ▁or ▁other ▁proto zo an ▁cl ades . ▁  Once ▁the ▁virus ▁inf ect s ▁the ▁host , ▁the ▁rep lication ▁cycle ▁takes ▁place ▁in ▁the ▁cy top las m . ▁Within ▁the ▁gen ome , ▁DNA ▁repair ▁en zym es ▁can ▁be ▁found . ▁These ▁are ▁used ▁when ▁the ▁DNA ▁is ▁har med ▁such ▁as ▁when ▁it ▁is ▁exposed ▁to ▁ion izing ▁radiation ▁or ▁U V ▁light . ▁ ▁Trad itionally ▁these ▁vir uses ▁have ▁been ▁grouped ▁into ▁a ▁family ▁M im iv ir idae . ▁Later ▁it ▁appeared ▁that ▁the ▁vir uses ▁of ▁the ▁Organ ic ▁Lake ▁Ph yc