ant ing ▁Institute ▁( named ▁after ▁Frederick ▁B ant ing ) ▁and ▁the ▁Department ▁of ▁B acter i ology , ▁both ▁at ▁the ▁University ▁of ▁Toronto . ▁In ▁ 1 9 4 3 , ▁Con n aught ▁acquired ▁more ▁processing ▁space ▁at ▁One ▁Sp ad ina ▁C res cent , ▁a ▁building ▁originally ▁established ▁for ▁Kno x ▁College , ▁then ▁during ▁W WI ▁used ▁for ▁Sp ad ina ▁Military ▁Hospital , ▁where ▁Am elia ▁Ear hart ▁had ▁worked ▁as ▁a ▁nur se ▁a ide . ▁ ▁T et anus ▁ ▁Con n aught ' s ▁previous ▁efforts ▁during ▁World ▁War ▁I ▁( 1 9 1 4 - 1 9 1 8 ) ▁had ▁led ▁to ▁a ▁highly ▁successful ▁campaign ▁foc using ▁on ▁treatment ▁of ▁affected ▁soldiers . ▁In ▁ 1 9 2 7 , ▁Con n aught ▁had ▁begun ▁to ▁build ▁on ▁recent ▁adv ances ▁by ▁Gast on ▁Ram on ▁at ▁P aste ur ▁Institute ▁to ▁develop ▁various ▁to x oid s ▁( in activ ated ▁to x ins ▁used ▁to ▁v acc inate ▁against ▁future ▁in fe ctions ). ▁ ▁During ▁W W II , ▁Con n aught ▁intens ified ▁research ▁on ▁the ▁t et anus ▁to x oid ▁to ▁eliminate ▁its ▁negative ▁side - effect s ▁and ▁scale ▁production . ▁Ed ith ▁M . ▁Taylor ▁led ▁these ▁efforts , ▁building ▁on ▁previous ▁success es ▁with ▁the ▁di ph ther ia ▁to x oid . ▁Her ▁methods ▁for ▁prepar ing ▁the ▁t et anus ▁to x in ▁( from ▁which ▁the ▁to