▁of ▁alpha - 7 B ▁integr in ▁is ▁essential ▁for ▁reg ulation ▁of ▁l am el lip odia ▁formation ▁and ▁reg ulation ▁of ▁cell ▁mob ility ▁reg ulation ▁via ▁l amin in - 1 / E 8 ▁and ▁p 1 3 0 ( C AS )/ Cr k ▁complex ▁formation . ▁ ▁C lin ical ▁Sign ific ance ▁ ▁Mut ations ▁in ▁IT GA 7 ▁have ▁been ▁found ▁in ▁patients ▁with ▁un class ified ▁con gen ital ▁my op ath y . ▁Additionally , ▁in ▁patients ▁with ▁severe ▁con gen ital ▁fi ber ▁type ▁dis pro port ion ▁and ▁left ▁vent ric ular ▁non - comp action ▁card iom y op ath y , ▁a ▁miss ense ▁mut ation , ▁G lu 8 8 2 L ys , ▁was ▁identified ▁in ▁IT GA 7 ▁along ▁with ▁a ▁miss ense ▁mut ation ▁in ▁MY H 7 B , ▁both ▁novel ▁disease ▁gen es ▁having ▁a ▁syn erg istic ▁effect ▁on ▁disease ▁sever ity . ▁ ▁Al pha - 7 B ▁integr in ▁expression ▁has ▁been ▁shown ▁to ▁be ▁significantly ▁decre ased ▁at ▁sar co lem mal ▁memb ran es ▁in ▁patients ▁with ▁l amin in ▁alpha 2 ▁chain - def ic ient ▁con gen ital ▁mus cular ▁d yst ro phy . ▁Additionally , ▁in ▁Duch enne ▁mus cular ▁d yst ro phy ▁and ▁Be cker ▁mus cular ▁d yst ro phy , ▁the ▁expression ▁of ▁alpha - 7 B ▁integr in ▁was ▁en hanced . ▁ ▁Inter actions ▁▁ ▁IT GA 7 ▁has