▁place ▁by ▁separation ▁of ▁the ▁head - tail ▁connection ▁within ▁in active ▁vin cul in . ▁ ▁Binding ▁site ▁▁ ▁Vin cul in ▁binding ▁sites ▁are ▁pre domin antly ▁found ▁in ▁tal in ▁and ▁tal in - like ▁mole cules , ▁en abling ▁binding ▁of ▁vin cul in ▁to ▁tal in , ▁stabil ising ▁integr in - medi ated ▁cell - matrix ▁j unction s . ▁Tal in , ▁in ▁turn , ▁links ▁integr ins ▁to ▁the ▁act in ▁c yt os ke leton . ▁The ▁cons ensus ▁sequence ▁for ▁Vin cul in ▁binding ▁sites ▁is ▁L xx AA xx VA xx V xx LI xx A , ▁with ▁a ▁secondary ▁structure ▁prediction ▁of ▁four ▁am ph ip ath ic ▁hel ices . ▁The ▁hydro ph ob ic ▁resid ues ▁that ▁define ▁the ▁V BS ▁are ▁themselves ▁' mask ed ' ▁and ▁are ▁buried ▁in ▁the ▁core ▁of ▁a ▁series ▁of ▁hel ical ▁bund les ▁that ▁make ▁up ▁the ▁tal in ▁rod . ▁ ▁Sp lice ▁variants ▁▁ ▁Sm ooth ▁mus cles ▁and ▁ske let al ▁mus cles ▁( and ▁probably ▁to ▁a ▁lower ▁extent ▁in ▁card iac ▁mus cle ) ▁in ▁their ▁well - d iffer enti ated ▁( cont ract ile ) ▁state ▁co - express ▁( al ong ▁with ▁vin cul in ) ▁a ▁sp lice ▁variant ▁carrying ▁an ▁extra ▁ex on ▁in ▁the ▁ 3 ' ▁coding ▁region , ▁thus ▁encoding ▁a ▁longer ▁is o form ▁meta - vin cul in ▁( meta ▁V CL ) ▁of ▁~ 1