▁required ▁for ▁W nt ▁signal ing : ▁possibly ▁to ▁rec ruit ▁various ▁co activ ators , ▁such ▁as ▁ 1 4 - 3 - 3 zeta . ▁Yet ▁its ▁exact ▁partners ▁among ▁the ▁general ▁trans cription ▁complex es ▁are ▁still ▁unknown . ▁Not ably , ▁the ▁C - term inal ▁segment ▁of ▁ β - c aten in ▁can ▁m im ic ▁the ▁effects ▁of ▁the ▁entire ▁W nt ▁path way ▁if ▁artificial ly ▁f used ▁to ▁the ▁DNA ▁binding ▁domain ▁of ▁LE F 1 ▁trans cription ▁factor . ▁ ▁Pla k og lo bin ▁( also ▁called ▁g amma - c aten in ) ▁has ▁a ▁strik ingly ▁similar ▁architecture ▁to ▁that ▁of ▁beta - c aten in . ▁Not ▁only ▁their ▁AR M ▁domains ▁res emble ▁each ▁other ▁in ▁both ▁architecture ▁and ▁lig and ▁binding ▁capacity , ▁but ▁the ▁N - term inal ▁ β - Tr CP - binding ▁mot if ▁is ▁also ▁conser ved ▁in ▁pla k og lo bin , ▁imp lying ▁common ▁ancest ry ▁and ▁shared ▁reg ulation ▁with ▁ β - c aten in . ▁However , ▁pla k og lo bin ▁is ▁a ▁very ▁weak ▁trans activ ator ▁when ▁bound ▁to ▁DNA ▁– ▁this ▁is ▁probably ▁caused ▁by ▁the ▁diver gence ▁of ▁their ▁C - term inal ▁sequences ▁( pla k og lo bin ▁appears ▁to ▁lack ▁the ▁trans activ ator ▁mot ifs , ▁and ▁thus ▁in hib its ▁the ▁W nt ▁path way ▁target ▁gen es ▁instead ▁of ▁activ ating ▁them ). ▁ ▁Part