gs ▁whose ▁development ▁has ▁st alled ▁by ▁ident ifying ▁bar riers ▁to ▁commercial ization , ▁such ▁as ▁problems ▁with ▁form ulation ▁and ▁bio - processing . ▁ ▁N umer ous ▁advoc acy ▁groups ▁such ▁as ▁the ▁National ▁Organ ization ▁for ▁R are ▁Dis orders , ▁Global ▁Gen es ▁Project , ▁Children ' s ▁R are ▁D ise ase ▁Network , ▁Ab etal ip op rote in emia ▁Coll abor ation ▁Foundation , ▁Z ell weg er ▁Baby ▁Support ▁Network , ▁and ▁the ▁Fried reich ' s ▁A tax ia ▁Research ▁Alliance ▁have ▁been ▁founded ▁in ▁order ▁to ▁advoc ate ▁on ▁beh alf ▁of ▁ ▁patients ▁suffering ▁from ▁rare ▁dise ases ▁with ▁a ▁particular ▁emphas is ▁on ▁dise ases ▁that ▁aff lict ▁children . ▁ ▁Cost ▁According ▁to ▁a ▁ 2 0 1 5 ▁report ▁published ▁by ▁E valu ate Ph arma , ▁the ▁econom ics ▁of ▁or phan ▁dru gs ▁mirror s ▁the ▁econom ics ▁of ▁the ▁ph arma ce ut ical ▁market ▁as ▁a ▁whole ▁but ▁has ▁a ▁few ▁very ▁large ▁differences . ▁The ▁market ▁for ▁or phan ▁dru gs ▁is ▁by ▁definition ▁very ▁small , ▁but ▁while ▁the ▁customer ▁base ▁is ▁dr ast ically ▁smaller ▁the ▁cost ▁of ▁research ▁and ▁development ▁is ▁very ▁much ▁the ▁same ▁as ▁for ▁non ▁or phan ▁dru gs . ▁This , ▁the ▁produ cers ▁have ▁claimed , ▁causes ▁them ▁to ▁charge ▁extremely ▁high ▁amounts ▁for ▁treatment , ▁sometimes ▁as ▁high ▁as ▁$ 7 0 0 , 0 0 0 ▁a ▁year , ▁as ▁in ▁the ▁case