▁and ▁improved ▁the ▁di agnostic ▁sens itivity ▁for ▁Lyn ch ▁Sy nd rome ▁by ▁including ▁can cers ▁of ▁the ▁end omet rium , ▁small ▁bow el , ▁u re ter ▁and ▁ren al ▁pel vis . ▁ ▁Amsterdam ▁C riteria ▁II ▁( all ▁bullet ▁points ▁must ▁be ▁ful filled ): ▁Three ▁or ▁more ▁family ▁members ▁with ▁H NP CC - related ▁can cers , ▁one ▁of ▁whom ▁is ▁a ▁first - deg ree ▁relative ▁of ▁the ▁other ▁two ▁Two ▁success ive ▁affected ▁gener ations ▁One ▁or ▁more ▁of ▁the ▁H NP CC - related ▁can cers ▁diagn osed ▁under ▁age ▁ 5 0 ▁years ▁Famil ial ▁ad en om at ous ▁poly pos is ▁( F AP ) ▁has ▁been ▁ex cluded ▁ ▁The ▁Beth es da ▁criteria ▁were ▁developed ▁in ▁ 1 9 9 7 ▁and ▁later ▁updated ▁in ▁ 2 0 0 4 ▁by ▁the ▁National ▁Can cer ▁Institute ▁to ▁identify ▁persons ▁requiring ▁further ▁testing ▁for ▁Lyn ch ▁Sy nd rome ▁through ▁M SI . ▁In ▁contrast ▁to ▁the ▁Amsterdam ▁C riteria , ▁the ▁Re vised ▁Beth es da ▁Gu idel ines ▁use ▁path ological ▁data ▁in ▁addition ▁to ▁clin ical ▁information ▁to ▁help ▁health ▁care ▁prov iders ▁identify ▁persons ▁at ▁high - ris k . ▁ ▁Re vised ▁Beth es da ▁Gu idel ines : ▁ ▁If ▁a ▁person ▁meets ▁any ▁ 1 ▁of ▁ 5 ▁criteria ▁the ▁tum our ( s ) ▁from ▁the ▁person ▁should ▁be ▁tested ▁for ▁M SI : ▁▁ 1 . ▁Col ore ct al