it ization ▁( and ▁thus ▁action ▁potential ▁block age ▁with ▁a ▁mole c ule ▁capable ▁of ▁intersect ing ▁its ▁specific ▁channel , ▁in ▁the ▁case ▁of ▁c oca ine ▁a ▁sod ium ▁channel , ▁that ▁potentially ▁serves ▁in ▁re - quant ifying ▁its ▁charge ) ▁upon ▁a ▁re ceptor ▁binding ▁site ▁may ▁at ten uate ▁the ▁medi ating ▁influence ▁of ▁the ▁in hib itory ▁reg ulation ▁that ▁aut ore cept ors ▁play ▁by ▁their ▁slow ing ▁ne uro trans mit ter ▁release ▁when ▁an ▁eff l ux ▁is ▁created ▁through ▁an ▁instance ▁of ▁ag on ism ▁by ▁a ▁comp ound ; ▁allowing ▁said ▁eff l ux ▁to ▁be ▁continued ▁without ▁the ▁body ' s ▁attempt ▁to ▁maintain ▁home ost asis ▁en act ing ▁in ▁as ▁readily ▁respons ive ▁a ▁manner ▁to ▁its ▁conform ational ▁change . ▁▁ 3 β - Al k yl phen y lt rop ane ▁& ▁ 3 β - Al ken yl ▁analog ues ▁ ▁The ▁comp ound ▁ 2 2 4 e , ▁the ▁ 3 β - sty rene ▁analog ue , ▁had ▁the ▁highest ▁pot ency ▁in ▁its ▁group . ▁While ▁ 2 2 4 b ▁& ▁ 2 2 4 c ▁showed ▁the ▁most ▁select ivity , ▁with ▁ 2 2 4 b ▁having ▁a ▁ten - fold ▁greater ▁pot ency ▁for ▁the ▁dop am ine ▁trans porter ▁than ▁c oca ine . ▁▁ 6 - Al k yl - 3 - ben zy lt rop ane ▁analog ues ▁ ▁N . B . ▁that