iction . ▁Pre vious ▁research ▁has ▁found ▁that ▁dru gs ▁that ▁are ▁able ▁to ▁reduce ▁gl ut am ate ▁transmission ▁can ▁rel ieve ▁the ▁ne urop ath ic ▁pain , ▁although ▁the ▁result ant ▁side - effect s ▁have ▁limited ▁a ▁great ▁deal ▁of ▁their ▁clin ical ▁applications . ▁Therefore , ▁it ▁appears ▁that , ▁since ▁GC PI I ▁is ▁exclus ively ▁rec ru ited ▁for ▁the ▁purpose ▁of ▁providing ▁a ▁gl ut am ate ▁source ▁in ▁hyper gl ut am ater g ic ▁and ▁exc it ot ox ic ▁conditions , ▁this ▁could ▁be ▁an ▁alternative ▁to ▁a vert ▁these ▁side - effect s . ▁More ▁research ▁find ings ▁have ▁shown ▁that ▁the ▁hydro ly s is ▁of ▁N AA G ▁is ▁dis rupted ▁in ▁sch iz op hren ia , ▁and ▁they ▁have ▁shown ▁that ▁specific ▁an atom ical ▁regions ▁of ▁the ▁brain ▁may ▁even ▁show ▁discrete ▁ab normal ities ▁in ▁the ▁G CP ▁II ▁synth esis , ▁so ▁N P s ▁may ▁also ▁be ▁th era pe ut ic ▁for ▁patients ▁suffering ▁with ▁sch iz op hren ia . ▁One ▁major ▁hur d le ▁with ▁using ▁many ▁of ▁the ▁pot ent ▁GC PI I ▁in hib itors ▁that ▁have ▁been ▁prepared ▁to ▁date ▁are ▁typically ▁highly ▁polar ▁comp ounds , ▁which ▁causes ▁problems ▁because ▁they ▁do ▁not ▁then ▁pen et rate ▁the ▁blood – bra in ▁bar rier ▁easily . ▁ ▁Pot ential ▁uses ▁of ▁N AA G ▁pe pt id ase ▁in hib itors ▁▁ ▁Gl ut am ate