▁respons ive ▁meg al ob last ic ▁an emia ▁synd rome ▁( also ▁known ▁as ▁Rog ers ▁Sy nd rome ) ▁is ▁a ▁very ▁rare ▁gen etic ▁dis order ▁affect ing ▁a ▁th iam ine ▁trans porter , ▁which ▁is ▁character ized ▁by ▁meg al ob last ic ▁an emia , ▁di ab etes ▁m ell it us , ▁and ▁hearing ▁loss . ▁The ▁condition ▁is ▁treated ▁with ▁high ▁dos es ▁of ▁th iam ine ▁( v it amin ▁B 1 ). ▁ ▁Sign s ▁and ▁sympt oms ▁In ▁most ▁cases ▁( 8 0 - 9 9 % ), ▁people ▁with ▁this ▁condition ▁experience ▁poor ▁app et ite ▁( an ore x ia ), ▁di arr he a , ▁head ache , ▁and ▁le th arg y . ▁ ▁Th iam ine ▁respons ive ▁meg al ob last ic ▁an emia ▁synd rome ▁is ▁associated ▁with ▁progress ive ▁sensor ine ural ▁hearing ▁loss . ▁ ▁Add itional ▁manifest ations ▁include ▁opt ic ▁at ro phy , ▁short ▁stat ure , ▁en larg ed ▁li ver , ▁and ▁an ▁en larg ed ▁s ple en . ▁Some ▁cases ▁may ▁affect ▁the ▁heart , ▁leading ▁to ▁ab normal ▁heart ▁rh yth ms . ▁ ▁Tre at ment ▁Tre at ment ▁consists ▁of ▁high ▁dos es ▁of ▁or al ▁th iam ine . ▁ ▁Tre at ment ▁can ▁delay ▁the ▁on set ▁of ▁di ab etes ▁m ell it us , ▁and ▁revers es ▁an emia . ▁ ▁If ▁treatment ▁is ▁initi ated ▁early , ▁th