ary otes . ▁▁ ▁C oul om be ▁obtained ▁his ▁b ach elor ' s ▁degree ▁in ▁Bio chem istry ▁( 1 9 8 1 ) ▁and ▁his ▁Ph D ▁in ▁M ole cular ▁Bi ology ▁( 1 9 8 8 ) ▁at ▁the ▁University ▁of ▁Montreal ▁before ▁undert aking ▁post do ctor al ▁work ▁at ▁the ▁University ▁of ▁Toronto ▁and ▁the ▁Free ▁University ▁of ▁Br uss els ▁( UL B ). ▁He ▁then ▁moved ▁at ▁the ▁University ▁of ▁Sher bro oke ▁as ▁an ▁Ass istant ▁Professor ▁in ▁ 1 9 9 3 ▁where ▁he ▁att ained ▁the ▁ten ured ▁rank ▁of ▁Full ▁Professor , ▁and ▁to ▁the ▁Institut ▁de ▁recher ches ▁cl ini ques ▁de ▁Montr éal ▁in ▁ 2 0 0 1 . ▁▁ ▁C oul om be ▁is ▁best ▁known ▁for ▁his ▁" prom oter ▁wrapping ▁model " ▁for ▁trans cription al ▁init iation ▁by ▁multi - sub unit ▁R NA ▁polym er ases ▁( ), ▁which ▁has ▁been ▁described ▁in ▁mole cular ▁bi ology ▁text books ▁( ). ▁More ▁recently , ▁his ▁labor atory ▁has ▁used ▁protein ▁aff inity ▁pur ification ▁couple d ▁with ▁mass ▁spect rom etry ▁to ▁generate ▁high - resol ution ▁maps ▁of ▁the ▁interact ome ▁of ▁human ▁R NA ▁polym er ases ▁( , ). ▁In ▁ 2 0 1 2 , ▁the ▁C oul om be ▁labor atory ▁discovered ▁that ▁m eth yl ation ▁of ▁mole cular ▁ch aper ones ▁is ▁a ▁central ▁element ▁of ▁a ▁post trans l ational ▁modification ▁code , ▁they