▁en rich ed ▁for ▁targets ▁directly ▁connected ▁to ▁cancer ▁pro gression ▁such ▁as ▁ster oid - 5 - alpha - re duct ase ▁and ▁syn erg istic ▁targets ▁like ▁the ▁eff l ux ▁p ump ▁P - g p . ▁ ▁These ▁target - phen ot ype ▁links ▁can ▁help ▁identify ▁novel ▁MO As . ▁ ▁Bey ond ▁T CM ▁and ▁Ay ur ved a , ▁chem ogen om ics ▁can ▁be ▁applied ▁early ▁in ▁drug ▁discovery ▁to ▁determine ▁a ▁comp ound ' s ▁mechanism ▁of ▁action ▁and ▁take ▁advantage ▁of ▁genom ic ▁bi om ark ers ▁of ▁to x icity ▁and ▁effic acy ▁for ▁application ▁to ▁Ph ase ▁I ▁and ▁II ▁clin ical ▁tri als . ▁ ▁Ident ifying ▁new ▁drug ▁targets ▁▁ ▁Chem ogen om ics ▁profil ing ▁can ▁be ▁used ▁to ▁identify ▁totally ▁new ▁th era pe ut ic ▁targets , ▁for ▁example ▁new ▁ant ib acter ial ▁agents . ▁ ▁The ▁study ▁capital ized ▁on ▁the ▁avail ability ▁of ▁an ▁existing ▁lig and ▁library ▁for ▁an ▁en zym e ▁called ▁mur D ▁that ▁is ▁used ▁in ▁the ▁pe pt id og ly can ▁synth esis ▁path way . ▁▁ ▁R ely ing ▁on ▁the ▁chem ogen om ics ▁similarity ▁principle , ▁the ▁research ers ▁mapped ▁the ▁mur D ▁lig and ▁library ▁to ▁other ▁members ▁of ▁the ▁mur ▁lig ase ▁family ▁( m ur C , ▁mur E , ▁mur F , ▁mur A , ▁and ▁mur G ) ▁to ▁identify ▁new ▁targets ▁for ▁the ▁known ▁lig ands . ▁▁