▁with ▁OS LA M ▁synd rome ▁have ▁an ▁elev ated ▁risk ▁of ▁b one ▁cancer , ▁lim b ▁ab normal ities , ▁and ▁en larg ed ▁red ▁blood ▁cells . ▁ ▁Sign s ▁and ▁sympt oms ▁B one ▁cancer ▁Cur ved ▁fifth ▁fingers ▁( cl in od act y ly ) ▁with ▁bra ch ym es oph al ang y ▁( short ened ▁ph al anges ▁of ▁the ▁to es ▁and / or ▁fingers ▁( dig its )) ▁Abs ence ▁of ▁one ▁digital ▁ray ▁of ▁the ▁foot ▁( a ▁digit ▁and ▁corresponding ▁met ac arp al ▁or ▁met at ars al ▁b one ) ▁Bil ater al ▁radi ou ln ar ▁syn ost osis ▁En larg ed ▁red ▁blood ▁cells ▁D ental ▁decay ▁Short ▁stat ure ▁ ▁Di agn osis ▁ ▁Tre at ment ▁ ▁See ▁also ▁Li - F raum eni ▁synd rome ▁ ▁References ▁ ▁External ▁links ▁▁ ▁Category : Os se ous ▁and ▁ch ond rom at ous ▁ne op las ia ▁Category : S ar com a ▁Category : Her edit ary ▁can cers ▁Category : S y nd rom es <0x0A> </s> ▁The ▁E ster ▁Republic ▁is ▁a ▁small , ▁independent ▁month ly ▁newspaper ▁published ▁in ▁E ster , ▁Al aska , ▁and ▁established ▁January ▁ 1 9 9 9 . ▁The ▁paper ▁serves ▁as ▁an ▁alternative ▁media ▁publication ▁for ▁the ▁Tan ana ▁Valley . ▁It ▁is ▁the ▁only ▁newspaper ▁that ▁has ▁been ▁published ▁in ▁E ster ; ▁the ▁village ▁has ▁been ▁served ▁histor ically ▁by ▁Fair b