▁is ▁character ized ▁by ▁relatively ▁low ▁st iff ness ▁( “ soft ” ▁matrix ). ▁For ▁example , ▁am o eb oid ▁migration ▁of ▁tum or ▁cells ▁in ▁the ▁l ym ph atic ▁and ▁circul atory ▁systems ▁is ▁considered ▁as ▁migration ▁in ▁a ▁soft ▁matrix . <0x09> ▁ <0x09> ▁Con de el is ▁and ▁Seg all ▁el uc id ated ▁some ▁features ▁of ▁cell ▁migration ▁on ▁the ▁example ▁of ▁two ▁different ▁tum or ▁lines , ▁M TC ▁and ▁M TL n 3 , ▁under ▁in ▁vit ro ▁and ▁in ▁v ivo ▁conditions . ▁M TL n 3 ▁cells ▁that ▁have ▁a ▁high ▁met ast atic ▁potential ▁and ▁migr ate ▁probably ▁by ▁the ▁am o eb oid ▁mechanism ▁of ▁invas ive ▁growth ▁are ▁character ized ▁by ▁a ▁higher ▁level ▁of ▁expression ▁of ▁e pid erm al ▁growth ▁factor ▁re cept ors ▁( EG FR s ) ▁than ▁M TC ▁cells ▁with ▁a ▁low ▁met ast atic ▁potential . ▁Their ▁migration ▁is ▁associated ▁with ▁the ▁presence ▁of ▁blood ▁vessels ▁and ▁col lagen - cont aining ▁fib ers ▁in ▁the ▁surrounding ▁matrix . ▁T um or ▁cell ▁chem ot axis ▁towards ▁blood ▁vessels ▁is ▁believed ▁to ▁be ▁medi ated ▁by ▁the ▁signal ing ▁path ways ▁of ▁E G FR . <0x09> ▁ <0x09> ▁The ▁am o eb oid ▁mechanism ▁of ▁invasion ▁has ▁a ▁number ▁of ▁distinct ive ▁features . ▁It ▁is ▁character ized ▁by ▁a ▁weak ▁interaction ▁between ▁cells ▁and ▁the ▁surrounding ▁matrix , ▁as ▁well ▁as ▁a ▁lack ▁of ▁or ▁weak ▁foc al ▁contacts .