ulation ▁factors ▁are ▁reduced ▁because ▁the ▁li ver ▁cannot ▁product ively ▁synth size ▁them ▁as ▁it ▁did ▁when ▁health y . ▁Non eth eless , ▁there ▁are ▁two ▁exceptions ▁in ▁this ▁falling ▁t endency , ▁that ▁are , ▁co ag ulation ▁factor ▁VIII ▁and ▁von ▁Wille brand ▁factor , ▁a ▁plate let ▁ad hes ive ▁protein . ▁Both ▁in vers ely ▁rise ▁in ▁the ▁setting ▁of ▁he p atic ▁ins u ffic iency , ▁thanks ▁to ▁the ▁drop ▁of ▁he p atic ▁clear ance ▁and ▁compens atory ▁produ ctions ▁from ▁other ▁sites ▁of ▁the ▁body . ▁F ibr in ol ysis ▁generally ▁proceed s ▁faster ▁in ▁the ▁scenarios ▁of ▁ac ute ▁li ver ▁failure ▁as ▁well ▁as ▁advanced ▁stage ▁of ▁li ver ▁disease ▁in ▁contrast ▁to ▁chron ic ▁li ver ▁disease ▁in ▁which ▁concentration ▁of ▁f ibr in ogen ▁remains ▁un changed . ▁ ▁A ▁previously ▁und i agn osed ▁li ver ▁disease ▁may ▁become ▁evident ▁first ▁after ▁aut ops y . ▁Following ▁are ▁gross ▁path ology ▁images : ▁ ▁Tre at ment ▁ ▁Anti - vir al ▁medic ations ▁are ▁available ▁to ▁treat ▁in fe ctions ▁such ▁as ▁he pat itis ▁B . ▁Other ▁conditions ▁may ▁be ▁managed ▁by ▁slow ing ▁down ▁disease ▁pro gression , ▁for ▁example : ▁▁ ▁By ▁using ▁ster oid - based ▁dru gs ▁in ▁auto imm une ▁he pat itis . ▁ ▁Reg ular ly ▁removing ▁a ▁quantity ▁of ▁blood ▁from ▁a ▁ve in ▁( ven ese ction ) ▁in ▁the ▁iron ▁over load ▁condition , ▁hem