▁more ▁severe ▁case ▁of ▁c yst ic ▁fib ros is ▁than ▁individuals ▁with ▁the ▁wild - type ▁gene . ▁Ind ividual s ▁with ▁chron ic ▁ob struct ive ▁pul mon ary ▁dis order ▁were ▁impact ed ▁by ▁two ▁polym orph isms ▁in ▁the ▁AB CC 1 ▁gene . ▁If ▁an ▁individual ▁had ▁a ▁ 3 '- UT R ▁T 8 6 6 A ▁polym orphism , ▁they ▁generally ▁had ▁a ▁less ▁severe ▁case ▁of ▁C OP D ▁marked ▁by ▁less ▁infl amm ation ▁in ▁their ▁air ways . ▁On ▁the ▁other ▁hand , ▁an ▁individual ▁with ▁a ▁ 3 '- UT R ▁G 3 3 6 1 A ▁polym orphism ▁generally ▁had ▁a ▁more ▁severe ▁case ▁of ▁C OP D ▁that ▁was ▁accompanied ▁by ▁a ▁greater ▁amount ▁of ▁infl amm ation ▁in ▁their ▁air ways . ▁ ▁Al z heimer ' s ▁disease ▁ ▁The ▁ATP - binding ▁c ass ette ▁protein ▁AB CC 1 ▁has ▁received ▁attention ▁in ▁the ▁last ▁de cade ▁due ▁to ▁its ▁possible ▁connection ▁with ▁Al z heimer ’ s ▁disease . ▁One ▁of ▁the ▁more ▁prominent ▁signs ▁of ▁Al z heimer ' s ▁disease ▁is ▁the ▁accum ulation ▁of ▁ β - amy lo id ▁prote ins ▁in ▁the ▁brain . ▁As ▁these ▁prote ins ▁accum ulate , ▁they ▁begin ▁to ▁form ▁pla ques ▁that ▁inter f ere ▁with ▁signal ing ▁between ▁cells ▁of ▁the ▁nerv ous ▁system ▁found ▁within ▁the ▁brain . ▁Due ▁to ▁its ▁presence ▁in ▁the ▁ch or oid ▁p lex us ▁and ▁blood -