▁breath . ▁In ▁addition , ▁the ▁effic acy ▁of ▁do xy cy cl ine ▁and ▁er yth rom yc in ▁succ inate ▁may ▁be ▁reduced ▁by ▁alco hol ▁consumption . ▁Other ▁effects ▁of ▁alco hol ▁on ▁ant ib i otic ▁activity ▁include ▁alter ed ▁activity ▁of ▁the ▁li ver ▁en zym es ▁that ▁break ▁down ▁the ▁ant ib i otic ▁comp ound . ▁ ▁Ph arm ac od ynam ics ▁ ▁The ▁successful ▁outcome ▁of ▁ant im icro b ial ▁ther apy ▁with ▁ant ib acter ial ▁comp ounds ▁depends ▁on ▁several ▁factors . ▁These ▁include ▁host ▁defense ▁mechan isms , ▁the ▁location ▁of ▁in fection , ▁and ▁the ▁ph arm ac ok in etic ▁and ▁ph arm ac od ynamic ▁properties ▁of ▁the ▁ant ib acter ial . ▁A ▁b acter ic idal ▁activity ▁of ▁ant ib acter ial s ▁may ▁depend ▁on ▁the ▁b acter ial ▁growth ▁phase , ▁and ▁it ▁often ▁requires ▁on going ▁met abol ic ▁activity ▁and ▁division ▁of ▁b acter ial ▁cells . ▁These ▁find ings ▁are ▁based ▁on ▁labor atory ▁studies , ▁and ▁in ▁clin ical ▁settings ▁have ▁also ▁been ▁shown ▁to ▁eliminate ▁b acter ial ▁in fection . ▁Since ▁the ▁activity ▁of ▁ant ib acter ial s ▁depends ▁frequently ▁on ▁its ▁concentration , ▁in ▁vit ro ▁character ization ▁of ▁ant ib acter ial ▁activity ▁commonly ▁includes ▁the ▁determ ination ▁of ▁the ▁minimum ▁in hib itory ▁concentration ▁and ▁minimum ▁b acter ic idal ▁concentration ▁of ▁an ▁ant ib acter ial . ▁To ▁predict ▁clin ical ▁outcome