ysis ▁of ▁ext rac ell ular ▁matrix ▁components ▁by ▁various ▁secret ed ▁prote ases , ▁with ▁the ▁functions ▁of ▁integr in ▁re cept ors ▁being ▁retained . ▁The ▁role ▁of ▁the ▁trans cription ▁factor ▁Pr rx 1 , ▁which ▁determ ines ▁the ▁ability ▁of ▁breast ▁cancer ▁cells ▁for ▁invas ive ▁growth , ▁was ▁experiment ally ▁established . <0x09> ▁ <0x09> ▁It ▁was ▁shown ▁that ▁Z EB 1 ▁and ▁Z EB 2 ▁prote ins ▁with ▁a ▁z inc ▁finger ▁domain ▁are ▁able ▁to ▁directly ▁bind ▁to ▁prom ot ers , ▁thereby ▁indu cing ▁the ▁expression ▁of ▁mes en ch ym al ▁marker ▁gen es ▁and ▁suppress ing ▁the ▁expression ▁of ▁E - c ad her in ▁and ▁other ▁ep ith el ial ▁markers . <0x09> ▁ <0x09> ▁Similarly , ▁Sn ail ▁and ▁Sl ug ▁are ▁able ▁to ▁suppress ▁the ▁expression ▁of ▁the ▁E - c ad her in ▁gene ▁via ▁direct ▁binding ▁to ▁its ▁prom oter , ▁as ▁well ▁as ▁production ▁of ▁ep ith el ial ▁prote ins ▁such ▁as ▁des m op la kin ▁and ▁cla ud in , ▁and ▁activ ate ▁the ▁expression ▁of ▁v iment in ▁and ▁matrix ▁metal lo prote in ases , ▁thereby ▁increasing ▁cell ▁migration . ▁A ▁team ▁of ▁research ers ▁led ▁by ▁San chez - T illo ▁found ▁that ▁the ▁trans cription ▁factor ▁Sn ail ▁does ▁not ▁occur ▁in ▁normal ▁ep ith el ial ▁cells ▁and ▁that ▁its ▁detection ▁in ▁cells ▁of ▁the ▁tum or ▁invas ive ▁front ▁can ▁be ▁considered ▁as ▁a ▁predict or ▁of ▁poor