, ▁the ▁ant im icro b ial ▁activity ▁of ▁an ▁ant ib acter ial ▁is ▁usually ▁combined ▁with ▁its ▁ph arm ac ok in etic ▁profile , ▁and ▁several ▁ph arm ac ological ▁parameters ▁are ▁used ▁as ▁markers ▁of ▁drug ▁effic acy . ▁ ▁Com bin ation ▁ther apy ▁ ▁In ▁important ▁inf ect ious ▁dise ases , ▁including ▁t uber cul osis , ▁combination ▁ther apy ▁( i . e ., ▁the ▁concurrent ▁application ▁of ▁two ▁or ▁more ▁ant ib iot ics ) ▁has ▁been ▁used ▁to ▁delay ▁or ▁prevent ▁the ▁emer gence ▁of ▁resistance . ▁In ▁ac ute ▁b acter ial ▁in fe ctions , ▁ant ib iot ics ▁as ▁part ▁of ▁combination ▁ther apy ▁are ▁pres cribed ▁for ▁their ▁syn erg istic ▁effects ▁to ▁improve ▁treatment ▁outcome ▁as ▁the ▁combined ▁effect ▁of ▁both ▁ant ib iot ics ▁is ▁better ▁than ▁their ▁individual ▁effect . ▁M eth ic ill in - res istant ▁St ap hy loc oc cus ▁a ure us ▁in fe ctions ▁may ▁be ▁treated ▁with ▁a ▁combination ▁ther apy ▁of ▁fus id ic ▁acid ▁and ▁rif amp ic in . ▁Ant ib iot ics ▁used ▁in ▁combination ▁may ▁also ▁be ▁ant agon istic ▁and ▁the ▁combined ▁effects ▁of ▁the ▁two ▁ant ib iot ics ▁may ▁be ▁less ▁than ▁if ▁the ▁individual ▁ant ib i otic ▁was ▁given ▁as ▁part ▁of ▁a ▁mon other apy . ▁For ▁example , ▁ch lor am phen icol ▁and ▁t et racy cl ines ▁are ▁ant agon ists ▁to ▁pen ic ill