▁not ▁able ▁to ▁perform ▁their ▁my el ination ▁properly ▁as ▁they ▁only ▁wrap ▁their ▁cy top las mic ▁processes ▁one ▁and ▁half ▁turn ▁around ▁the ▁ax on ▁and ▁despite ▁the ▁fact ▁that ▁they ▁still ▁express ▁the ▁early ▁my elin ▁marker , ▁late ▁my elin ▁gene ▁products ▁are ▁absent . ▁In ▁addition , ▁recent ▁studies ▁have ▁also ▁proven ▁the ▁importance ▁of ▁this ▁trans cription ▁factor ▁in ▁maintain ing ▁the ▁my el ination ▁phen ot ype ▁( and ▁requires ▁the ▁co - expression ▁of ▁So x ▁ 1 0 ) ▁as ▁its ▁in activ ation ▁leads ▁to ▁ded iffer enti ation ▁of ▁the ▁Schw ann ▁cells . ▁ ▁C lin ical ▁significance ▁Char cot – Marie – To oth ▁disease ▁( C MT ), ▁Gu illa in – B arr é ▁synd rome ▁( GB S , ▁ac ute ▁infl am mat ory ▁dem y elin ating ▁poly rad icul op ath y ▁type ), ▁schw ann om atos is , ▁and ▁chron ic ▁infl am mat ory ▁dem y elin ating ▁poly ne urop ath y ▁( C ID P ), ▁le pro s y , ▁and ▁Z ika ▁Vir us ▁are ▁all ▁ne urop ath ies ▁involving ▁Schw ann ▁cells . ▁ ▁Trans plant ation ▁A ▁number ▁of ▁experimental ▁studies ▁since ▁ 2 0 0 1 ▁have ▁impl anted ▁Schw ann ▁cells ▁in ▁an ▁attempt ▁to ▁indu ce ▁rem y el ination ▁in ▁multiple ▁s cl eros is - aff lic ted ▁patients . ▁In ▁the ▁past ▁two ▁dec ades , ▁many ▁studies