▁isol ates ▁with ▁N DM - 1 ▁en zym e ▁are ▁resist ant ▁to ▁all ▁standard ▁int ra ven ous ▁ant ib iot ics ▁for ▁treatment ▁of ▁severe ▁in fe ctions ." ▁On ▁ 2 6 ▁May ▁ 2 0 1 6 ▁an ▁E ▁col i ▁b acter ia ▁" super bug " ▁was ▁identified ▁in ▁the ▁United ▁States ▁resist ant ▁to ▁col ist in , ▁" the ▁last ▁line ▁of ▁defence " ▁ant ib i otic . ▁ ▁Mis use ▁ ▁Per ▁The ▁IC U ▁Book ▁" The ▁first ▁rule ▁of ▁ant ib iot ics ▁is ▁try ▁not ▁to ▁use ▁them , ▁and ▁the ▁second ▁rule ▁is ▁try ▁not ▁to ▁use ▁too ▁many ▁of ▁them ." ▁In app ropri ate ▁ant ib i otic ▁treatment ▁and ▁over use ▁of ▁ant ib iot ics ▁have ▁contributed ▁to ▁the ▁emer gence ▁of ▁ant ib i otic - res istant ▁b acter ia . ▁Self - pres cri bing ▁of ▁ant ib iot ics ▁is ▁an ▁example ▁of ▁mis use . ▁Many ▁ant ib iot ics ▁are ▁frequently ▁pres cribed ▁to ▁treat ▁sympt oms ▁or ▁dise ases ▁that ▁do ▁not ▁respond ▁to ▁ant ib iot ics ▁or ▁that ▁are ▁likely ▁to ▁resolve ▁without ▁treatment . ▁Also , ▁incorrect ▁or ▁sub opt imal ▁ant ib iot ics ▁are ▁pres cribed ▁for ▁certain ▁b acter ial ▁in fe ctions . ▁The ▁over use ▁of ▁ant ib iot ics , ▁like ▁pen ic ill in ▁and ▁er yth rom yc in , ▁has ▁been ▁associated ▁with ▁emer ging