olds ▁number ▁and ▁curve ▁radius ▁of ▁curv ature . ▁ ▁For ▁example , ▁in ▁a ▁straight ▁channel , ▁larger ▁cells ▁in ▁col lo idal ▁solution ▁are ▁found ▁closer ▁to ▁the ▁center ▁of ▁the ▁micro channel ▁than ▁smaller ▁cells ▁due ▁to ▁the ▁larger ▁drag ▁forces ▁from ▁the ▁wall ▁that ▁push es ▁the ▁cell ▁away ▁from ▁the ▁wall ▁and ▁the ▁she ar ▁gradient ▁force ▁from ▁the ▁velocity ▁profile ▁that ▁bal ances ▁this ▁wall ▁drag ▁force ▁to ▁set ▁the ▁cell ▁into ▁equilibrium . ▁ ▁While ▁micro fl uid ic ▁devices ▁are ▁receiving ▁a ▁lot ▁of ▁attention ▁from ▁the ▁university ▁and ▁research ▁se ctors , ▁there ▁lack ▁of ▁commercial ization ▁is ▁due ▁to ▁their ▁lack ▁of ▁complete ▁integration ▁such ▁as ▁need ing ▁complex ▁control ▁or ▁highly ▁specific ▁val ves ▁or ▁tub ing ▁and ▁their ▁in ability ▁to ▁scale ▁up ▁to ▁an ▁industrial ▁process ▁due ▁to ▁P D MS ▁dissol ving ▁g ases ▁and ▁losing ▁integrity ▁over ▁time . ▁The ▁lifetime ▁of ▁these ▁devices ▁due ▁to ▁b ubble ▁formation ▁or ▁cell ▁ent rap ment ▁is ▁fairly ▁short ▁which ▁affect s ▁output ▁and ▁pur ity ▁levels ▁after ▁only ▁a ▁few ▁cycles . ▁ ▁Bu oy ancy ▁activ ated ▁ ▁Bu oy ancy ▁activ ated ▁cell ▁sorting ▁( B AC S ), ▁developed ▁by ▁A ka de um ▁Life ▁Sciences , ▁is ▁a ▁separation ▁technique ▁in ▁which ▁micro b ub bles ▁bind ▁to ▁cells ▁through ▁ant ib od ies ▁binding ▁to ▁the ▁surface ▁of ▁cells . ▁The ▁target ed ▁cells ▁are ▁then ▁removed ▁from ▁a ▁bi ological ▁sample ▁through ▁fl