te ▁migration ). ▁A ▁similar ▁mechanism ▁of ▁dis sem ination ▁is ▁typical ▁of ▁cancer ▁cells ▁during ▁tum or ▁pro gression ▁and ▁met ast asis . <0x09> ▁ <0x09> ▁Al ong ▁with ▁single ▁cell ▁migration , ▁collect ive ▁cell ▁migration ▁can ▁occur ▁when ▁groups ▁of ▁firm ly ▁inter connected ▁tum or ▁cells ▁are ▁migr ating . ▁This ▁type ▁of ▁migration ▁indicates ▁t issue ▁re arr ang ement , ▁under lies ▁the ▁processes ▁of ▁emb ry onic ▁morph ogen esis , ▁and ▁also ▁is ▁an ▁essential ▁component ▁in ▁the ▁he aling ▁of ▁w ound ▁surfaces . <0x09> ▁ <0x09> ▁Therefore , ▁the ▁key ▁is ▁that ▁m align ant ▁tum or ▁cells ▁extens ively ▁use ▁the ▁mechan isms ▁of ▁both ▁collect ive ▁and ▁single ▁cell ▁migration ▁as ▁phys i ological ▁pro tot ypes ▁in ▁the ▁process ▁of ▁invas ive ▁growth ▁and ▁met ast asis . ▁ ▁Pattern s ▁of ▁invas ive ▁growth ▁At ▁present , ▁based ▁on ▁a ▁complex ▁of ▁certain ▁morph ological ▁and ▁mole cular ▁gen etic ▁parameters , ▁two ▁fund ament ally ▁different ▁patterns ▁of ▁invas ive ▁growth ▁are ▁distinguished : ▁collect ive ▁( group ) ▁cell ▁migration ▁and ▁single ▁cell ▁migration ▁( ind ividual ▁migration : ▁Fig . ▁ 1 ). ▁In ▁this ▁case , ▁the ▁migration ▁type ▁is ▁largely ▁determined ▁by ▁t issue ▁micro environment ▁features ▁and ▁depends ▁on ▁mole cular ▁changes ▁in ▁tum or ▁cells . <0x09> ▁ <0x09> ▁ <0x09> ▁ <0x09> ▁Det erm ination ▁of ▁the ▁invasion ▁mechanism ▁used ▁by ▁single ▁migr ating ▁cells ▁during ▁migration ▁is ▁a ▁complex