aging ▁or ▁“ loading ” ▁influ ences ▁on ▁cells ▁special ized ▁functions . ▁According ▁to ▁T AS ▁concept ▁in ▁dynamic ▁phase ▁of ▁t issue ▁stress ▁a ▁summ ation ▁of ▁dam aging ▁influence ▁of ▁str essor ▁( str ess ors ) ▁with ▁cells ▁self - dam age ▁by ▁T AS ▁effect ors ▁occurs . ▁This ▁leads ▁to ▁stim ulation ▁of ▁pro l ifer ation ▁( see ▁Pro l ifer ation ) ▁and ▁to ▁an ▁increase ▁of ▁apo pt otic ▁activity ▁( see ▁A po pt osis ) ▁simultaneously . ▁Thus , ▁in ▁above ▁case ▁adapt ive ▁function ▁of ▁t issue ▁stress ▁real izes ▁by ▁replacement ▁of ▁dam aged , ▁dying ▁cells ▁by ▁descend ants ▁of ▁cells ▁more ▁resist ant ▁to ▁str essor ( s ) ▁influence . ▁ ▁As ▁is ▁clear ▁from ▁the ▁for ego ing ▁according ▁the ▁T AS ▁concept ▁t issue ▁stress ▁mechanism ▁effect ▁on ▁hom olog ous ▁t issue ▁cells ▁is ▁mult if ari ous . ▁It ▁may ▁protect ▁them ▁against ▁the ▁un specific ▁dam aging ▁influ ences ▁as ▁well ▁as ▁to ▁increase ▁stability ▁of ▁t issue ▁special ized ▁functions ▁in ▁the ▁conditions ▁of ▁prolong ed ▁int ensive ▁functional ▁activity . ▁Sim ult ane ously , ▁the ▁same ▁mechanism ▁performs ▁intr at issue ▁control ▁of ▁cell ▁mass ▁of ▁hom olog ous ▁t issue . ▁ ▁References ▁G . M . ▁El b ak id ze , ▁A . G . ▁El b ak id ze ▁ ▁In trat issue ▁reg ulation ▁of ▁cell ▁mass ▁and ▁t issue ▁stress ▁// ▁Moscow ,