▁separate ▁into ▁iron - free ▁active ▁mon om ers , ▁which ▁restore ▁Gr x 2 ’ s ▁activity . ▁ ▁C lin ical ▁significance ▁ ▁From ▁ 4 2 ▁cases ▁of ▁non - small ▁cell ▁lung ▁cancer ▁patients , ▁the ▁expression ▁level ▁of ▁Gr x 2 ▁showed ▁a ▁significant ▁correlation ▁with ▁the ▁degree ▁of ▁different iation ▁in ▁ad en oc arc in oma ▁and ▁a ▁clear ▁inverse ▁correlation ▁with ▁pro l ifer ation . ▁In ▁tum or ▁cells , ▁cells ▁with ▁decre ased ▁Gr x 2 ▁are ▁dram atically ▁sens it ized ▁to ▁cell ▁death ▁induced ▁by ▁the ▁anti - can cer ▁drug , ▁DO X . ▁ ▁In ▁card i ov asc ular ▁disease , ▁Gr x 2 a ▁over expression ▁protect s ▁mouse ▁heart ▁from ▁Do x ▁and ▁is chem ia - indu ced ▁card iac ▁injury , ▁potentially ▁via ▁increasing ▁mit och ond rial ▁protein ▁gl ut ath ion yl ation . ▁Con vers ely , ▁Gr x 2 ▁knock out ▁hearts ▁developed ▁left ▁vent ric ular ▁hy pert ro phy ▁and ▁fib ros is , ▁leading ▁to ▁hy pert ension . ▁The ▁mechan istic ▁study ▁shows ▁that ▁Gr x 2 ▁knock out ▁decre ased ▁mit och ond rial ▁ATP ▁production , ▁possibly ▁via ▁increased ▁gl ut ath ion yl ation ▁and ▁thereby ▁in hib ition ▁of ▁complex ▁I . ▁ ▁Inter actions ▁▁ ▁Gr x 2 ▁has ▁been ▁shown ▁to ▁phys ically ▁interact ▁with ▁MD H 2 , ▁P IT PN B , ▁GP X 4 , ▁C Y