▁the ▁complex ▁to ▁the ▁m R NA . ▁The ▁edited ▁c yt id ine ▁resid ue ▁is ▁located ▁at ▁nucle ot ide ▁ 6 6 6 6 ▁located ▁in ▁ex on ▁ 2 6 ▁of ▁the ▁gene . ▁Edit ing ▁at ▁this ▁site ▁results ▁in ▁a ▁cod on ▁change ▁from ▁a ▁Gl ut am ine ▁cod on ▁( CAA ) ▁to ▁an ▁in frame ▁stop ▁cod on ▁( U AA ). ▁ ▁Computer ▁mod elling ▁has ▁detected ▁for ▁editing ▁to ▁occur , the ▁edited ▁C yt id ine ▁ ▁is ▁located ▁in ▁a ▁loop . ▁The ▁selection ▁of ▁the ▁edited ▁c yt id ine ▁is ▁also ▁highly ▁dependent ▁on ▁this ▁secondary ▁structure ▁of ▁the ▁surrounding ▁R NA . ▁There ▁are ▁also ▁some ▁indic ations ▁that ▁this ▁loop ▁region ▁is ▁formed ▁between ▁the ▁mo oring ▁sequence ▁and ▁the ▁ 3 ′ ▁regul atory ▁region ▁of ▁the ▁A po B ▁m R NA . ▁The ▁predicted ▁secondary ▁structure ▁formed ▁by ▁A po B ▁m R NA ▁is ▁thought ▁to ▁allow ▁for ▁contact ▁between ▁the ▁ ▁resid ue ▁to ▁be ▁edited ▁and ▁the ▁active ▁site ▁of ▁AP OB EC 1 ▁as ▁well ▁as ▁for ▁binding ▁of ▁A CF ▁and ▁other ▁auxili ary ▁factors ▁associated ▁with ▁the ▁edit os ome . ▁ ▁Reg ulation ▁ ▁Edit ing ▁of ▁A po B ▁m R NA ▁in ▁humans ▁is ▁t issue ▁reg ulated , ▁with ▁A po B 4 8 ▁being ▁the ▁main ▁A po B ▁protein ▁of ▁the ▁small ▁int est ine ▁in ▁humans . ▁It ▁occurs ▁in