- block er . ▁Un like ▁car ved il ol , ▁it ▁has ▁a ▁nit ric ▁ox ide ▁( NO )- pot enti ating , ▁vas od il atory ▁effect ▁via ▁stim ulation ▁of ▁ β 3 ▁re cept ors . ▁Al ong ▁with ▁lab etal ol , ▁cel ip rol ol ▁and ▁car ved il ol , ▁it ▁is ▁one ▁of ▁four ▁beta ▁block ers ▁to ▁cause ▁d ilation ▁of ▁blood ▁vessels ▁in ▁addition ▁to ▁effects ▁on ▁the ▁heart . ▁ ▁Anti hy pert ensive ▁effect ▁Neb iv ol ol ▁low ers ▁blood ▁pressure ▁( B P ) ▁by ▁reducing ▁peri pher al ▁v asc ular ▁resistance , ▁and ▁significantly ▁increases ▁stroke ▁volume ▁with ▁pres ervation ▁of ▁card iac ▁output . ▁The ▁net ▁hem od ynamic ▁effect ▁of ▁ne b iv ol ol ▁is ▁the ▁result ▁of ▁a ▁balance ▁between ▁the ▁de press ant ▁effects ▁of ▁beta - block ade ▁and ▁an ▁action ▁that ▁maintain s ▁card iac ▁output . ▁Anti hy pert ensive ▁responses ▁were ▁significantly ▁higher ▁with ▁ne b iv ol ol ▁than ▁with ▁place bo ▁in ▁tri als ▁en rolling ▁patient ▁groups ▁considered ▁representative ▁of ▁the ▁U . S . ▁hy pert ensive ▁population , ▁in ▁black ▁people , ▁and ▁in ▁those ▁receiving ▁concurrent ▁treatment ▁with ▁other ▁anti hy pert ensive ▁dru gs . ▁ ▁Ph arm ac ology ▁of ▁side - effect s ▁Several ▁studies ▁have ▁suggested ▁that ▁ne b iv ol ol ▁has ▁reduced ▁typical ▁beta - block er - related ▁side ▁effects , ▁such ▁as ▁fat