▁A ▁recom bin ant ▁form ▁of ▁human ▁factor ▁VII a ▁( e pt ac og ▁al fa ▁[ activ ated ], ▁Nov o Se ven ) ▁has ▁U . S . ▁Food ▁and ▁D rug ▁Administration ▁appro val ▁for ▁un control led ▁ble eding ▁in ▁hem oph ilia ▁patients . ▁It ▁is ▁sometimes ▁used ▁un lic ensed ▁in ▁severe ▁un cont roll able ▁ble eding , ▁although ▁there ▁have ▁been ▁safety ▁concerns . ▁A ▁b ios im ilar ▁form ▁of ▁recom bin ant ▁activ ated ▁factor ▁VII ▁( A ry o Se ven ) ▁is ▁also ▁available , ▁but ▁does ▁not ▁play ▁any ▁considerable ▁role ▁in ▁the ▁market . ▁ ▁Phys i ology ▁▁ ▁The ▁main ▁role ▁of ▁factor ▁VII ▁( F V II ) ▁is ▁to ▁initi ate ▁the ▁process ▁of ▁co ag ulation ▁in ▁conj unction ▁with ▁t issue ▁factor ▁( TF / factor ▁III ). ▁T issue ▁factor ▁is ▁found ▁on ▁the ▁outside ▁of ▁blood ▁vessels ▁- ▁normally ▁not ▁exposed ▁to ▁the ▁blood stream . ▁Upon ▁vessel ▁injury , ▁t issue ▁factor ▁is ▁exposed ▁to ▁the ▁blood ▁and ▁circul ating ▁factor ▁VII . ▁Once ▁bound ▁to ▁T F , ▁F V II ▁is ▁activ ated ▁to ▁F V II a ▁by ▁different ▁prote ases , ▁among ▁which ▁are ▁th rom bin ▁( factor ▁II a ), ▁factor ▁X a , ▁IX a , ▁XII a , ▁and ▁the ▁F V II a - TF ▁complex ▁itself . ▁The ▁complex ▁of ▁factor ▁VII a ▁with ▁T F ▁catal y zes ▁the