▁DNA , ▁due ▁to ▁the ▁presence ▁of ▁the ▁A 3 2 4 3 G ▁mut ation . ▁However , ▁in ▁other ▁people , ▁the ▁same ▁amount ▁of ▁mit och ond rial ▁prote ins ▁are ▁generated , ▁but ▁their ▁stability ▁is ▁comprom ised ▁due ▁to ▁the ▁impro per ▁incorpor ation ▁of ▁am ino ▁ac ids ▁at ▁the ▁U UR ▁cod ons ▁of ▁the ▁mit och ond rial ▁m R N As . ▁This ▁is ▁a ▁result ▁of ▁the ▁mut ated ▁t R N AL eu ( U UR ) ▁with ▁its ▁decre ased ▁function ▁in ▁protein ▁synth esis . ▁ <0x09> A ▁decrease ▁in ▁function ▁of ▁the ▁resp ir atory ▁chain ▁as ▁a ▁result ▁of ▁a ▁mit och ond rial ▁DNA ▁mut ation ▁could ▁result ▁in ▁a ▁decrease ▁of ▁ATP ▁production . ▁This ▁decrease ▁in ▁ATP ▁could ▁have ▁det r iment al ▁effects ▁on ▁other ▁processes ▁in ▁the ▁body . ▁One ▁such ▁process ▁is ▁ins ul in ▁secret ion ▁by ▁pan cre atic ▁B eta - cell s . ▁In ▁pan cre atic ▁B eta - cell s , ▁precise ▁levels ▁of ▁ATP / AD P ▁reg ulate ▁the ▁opening ▁and ▁closing ▁of ▁the ▁K AT P ▁channel , ▁which ▁controls ▁the ▁secret ion ▁of ▁ins ul in . ▁When ▁mut ations ▁in ▁the ▁mit och ond ria ▁dis rupt ▁the ▁ATP / AD P ▁ratio , ▁this ▁channel ▁cannot ▁function ▁properly ▁and ▁this ▁can ▁result ▁in ▁a ▁person ▁being ▁def ic ient ▁in ▁ins ul in . ▁Since ▁the ▁age ▁of ▁on set