ac us ▁man ic atus ) ▁was ▁discovered ; ▁it ▁was ▁shown ▁to ▁bind ▁TR PA 1 ▁non - c oval ently ▁in ▁the ▁same ▁region ▁as ▁elect roph iles ▁and ▁act ▁as ▁a ▁g ating ▁mod ifier ▁to x in ▁for ▁the ▁re ceptor , ▁stabil izing ▁the ▁channel ▁in ▁an ▁open ▁con formation . ▁ ▁TR PA 1 ▁in hib ition ▁Resol vin ▁D 1 ▁( R v D 1 ) ▁and ▁R v D 2 ▁( see ▁resol v ins ) ▁and ▁mar es in ▁ 1 ▁ ▁are ▁met abol ites ▁of ▁the ▁om ega ▁ 3 ▁fat ty ▁acid , ▁doc osa he xa eno ic ▁acid . ▁They ▁are ▁members ▁of ▁the ▁special ized ▁pr ores ol ving ▁medi ators ▁( SP M s ) ▁class ▁of ▁met abol ites ▁that ▁function ▁to ▁resolve ▁diverse ▁infl am mat ory ▁re actions ▁and ▁dise ases ▁in ▁animal ▁models ▁and , ▁it ▁is ▁proposed , ▁in ▁humans . ▁These ▁SP M s ▁also ▁d amp ▁pain ▁per ception ▁ar ising ▁from ▁various ▁infl amm ation - based ▁causes ▁in ▁animal ▁models . ▁The ▁mechanism ▁behind ▁their ▁pain - d amp ening ▁effect ▁involves ▁the ▁in hib ition ▁of ▁TR PA 1 , ▁probably ▁( in ▁at ▁least ▁certain ▁cases ) ▁by ▁an ▁indirect ▁effect ▁where in ▁they ▁activ ate ▁another ▁re ceptor ▁located ▁on ▁neur ons ▁or ▁nearby ▁micro gl ia ▁or ▁ast ro cy tes . ▁C M K LR 1 , ▁G PR 3 2 , ▁F