▁because ▁an and am ide ▁is ▁able ▁to ▁cross ▁the ▁blood – bra in ▁bar rier ▁and ▁act ▁within ▁the ▁central ▁nerv ous ▁system . ▁Thus , ▁because ▁an and am ide ▁is ▁a ▁eu ph ori ant ▁and ▁aer ob ic ▁exercise ▁is ▁associated ▁with ▁eu ph or ic ▁effects , ▁it ▁has ▁been ▁proposed ▁that ▁an and am ide ▁partly ▁medi ates ▁the ▁short - term ▁m ood - l ifting ▁effects ▁of ▁exercise ▁( e . g ., ▁the ▁eu ph oria ▁of ▁a ▁runner ' s ▁high ) ▁via ▁exercise - indu ced ▁increases ▁in ▁its ▁synth esis . ▁▁ ▁In ▁m ice ▁it ▁was ▁demonstrated ▁that ▁certain ▁features ▁of ▁a ▁runner ' s ▁high ▁depend ▁on ▁can nab ino id ▁re cept ors . ▁Ph arm ac ological ▁or ▁gen etic ▁dis ruption ▁of ▁can nab ino id ▁signal ing ▁via ▁can nab ino id ▁re cept ors ▁prevents ▁the ▁anal ges ic ▁and ▁anx iety - redu cing ▁effects ▁of ▁running . ▁ ▁Cort is ol ▁and ▁the ▁psych ological ▁stress ▁response ▁▁▁ ▁The ▁" str ess ▁h orm one ", ▁cort is ol , ▁is ▁a ▁gl uc oc ort ico id ▁that ▁bind s ▁to ▁gl uc oc ort ico id ▁re cept ors . ▁Psych ological ▁stress ▁indu ces ▁the ▁release ▁of ▁cort is ol ▁from ▁the ▁ad ren al ▁g land ▁by ▁activ ating ▁the ▁hypoth al am ic – p itu it ary – ad ren al ▁axis ▁( HP A ▁axis