etes ▁m ell it us ▁is ▁a ▁met abol ic ▁dis order ▁and ▁hence ▁the ▁defect s ▁observed ▁in ▁di ab etic ▁w ound ▁he aling ▁are ▁thought ▁to ▁be ▁the ▁result ▁of ▁alter ed ▁protein ▁and ▁li pid ▁met abol ism ▁and ▁thereby ▁ab normal ▁gran ulation ▁t issue ▁formation . ▁In cre ased ▁gl uc ose ▁levels ▁in ▁the ▁body ▁end ▁up ▁in ▁un control led ▁c oval ent ▁bond ing ▁of ▁al d ose ▁sug ars ▁to ▁a ▁protein ▁or ▁li pid ▁without ▁any ▁normal ▁g ly cos yl ation ▁en zym es . ▁These ▁stable ▁products ▁then ▁accum ulate ▁over ▁the ▁surface ▁of ▁cell ▁memb ran es , ▁struct ural ▁prote ins ▁and ▁circul ating ▁prote ins . ▁These ▁products ▁are ▁called ▁advanced ▁g ly cation ▁end products ▁( AGE s ) ▁or ▁Am ador i ▁products . ▁Form ation ▁of ▁A GE s ▁occurs ▁on ▁ext rac ell ular ▁matrix ▁prote ins ▁with ▁slow ▁turn over ▁rate . ▁A GE s ▁alter ▁the ▁properties ▁of ▁matrix ▁prote ins ▁such ▁as ▁col lagen , ▁vit ron ect in , ▁and ▁l amin in ▁through ▁A GE - AGE ▁inter m ole cular ▁c oval ent ▁b onds ▁or ▁cross - link ing . ▁A GE ▁cross - link ing ▁on ▁type ▁I ▁col lagen ▁and ▁el ast in ▁results ▁in ▁increased ▁st iff ness . ▁A GE s ▁are ▁also ▁known ▁to ▁increase ▁synth esis ▁of ▁type ▁III ▁col lagen ▁that ▁forms ▁the ▁gran ulation ▁t issue . ▁A