is , ▁prominent ▁infl am mat ory ▁in fil tr ates , ▁and / or ▁diff use ▁calc ification . ▁ ▁Path ology ▁ ▁Mut ations ▁in ▁human ▁P HO X 2 B ▁cause ▁a ▁rare ▁disease ▁of ▁the ▁vis cer al ▁nerv ous ▁system ▁( d ys aut onom ia ): ▁con gen ital ▁central ▁hyp ov ent ilation ▁synd rome ▁( associ ated ▁with ▁resp ir atory ▁arr ests ▁during ▁sleep ▁and , ▁occasionally , ▁w ake ful ness ), ▁Hir sch spr ung ' s ▁disease ▁( partial ▁ag en esis ▁of ▁the ▁enter ic ▁nerv ous ▁system ), ▁RO HH AD , ▁and ▁tum ours ▁of ▁the ▁sympath etic ▁gang lia . ▁In ▁most ▁people , ▁Ex on ▁ 3 ▁of ▁the ▁gene ▁contains ▁a ▁sequence ▁of ▁ 2 0 ▁pol yal an ine ▁repe ats . ▁An ▁increase ▁in ▁the ▁number ▁of ▁repe ats ▁is ▁associated ▁with ▁con gen ital ▁central ▁hyp ov ent ilation ▁synd rome . ▁There ▁may ▁also ▁be ▁other ▁path ogen ic ▁mut ations ▁further ▁along ▁the ▁gene . ▁ ▁References ▁ ▁Further ▁reading ▁ ▁External ▁links ▁▁ ▁Gene Re views / NC BI / NI H / U W ▁entry ▁on ▁Cong en ital ▁Central ▁Hyp ov ent ilation ▁Sy nd rome ▁▁▁ ▁Category : Trans cription ▁factors <0x0A> </s> ▁" Up ▁Out ▁My ▁Face " ▁is ▁a ▁song ▁by ▁American ▁singer ▁and ▁song writer ▁Maria h ▁Care y ▁from ▁her ▁tw elf th ▁studio ▁album , ▁Mem oir s ▁of ▁an ▁Imper