ase ▁beta ▁gen es . ▁The ▁protein ▁has ▁been ▁local ized ▁to ▁the ▁nucle us , ▁and ▁also ▁to ▁the ▁cy top las m ▁and ▁cent ros om es ▁during ▁mit osis . ▁Multiple ▁trans cript ▁variants ▁encoding ▁different ▁is o forms ▁have ▁been ▁found ▁for ▁this ▁gene . ▁At ▁least ▁three ▁of ▁the ▁trans cript s ▁code ▁for ▁a ▁protein ▁containing ▁all ▁ex ons , ▁referred ▁to ▁as ▁full - length ▁( FL ). ▁ ▁The ▁mouse ▁hom olog ▁of ▁F L - S cy l 1 ▁is ▁ 9 0 % ▁identical ▁and ▁ 9 3 % ▁similar ▁in ▁am ino ▁acid ▁content ▁to ▁human ▁F L - S cy l 1 . ▁In ▁Mus ▁Mus cul us ▁F L - S cy l 1 ▁enc odes ▁an ▁ 8 0 6 - am ino ▁acid ▁pol ype pt ide . ▁The ▁F L ▁protein ▁contains ▁HE AT ▁repe ats ▁and ▁a ▁C - term inal ▁co iled ▁co il ▁domain ▁that ▁also ▁contains ▁multiple ▁di basic ▁mot ifs , ▁and ▁ends ▁in ▁the ▁di basic ▁mot if ▁R K LD - CO OH . ▁ ▁S cy l 1 ▁local izes ▁to ▁the ▁c is - G ol gi ▁and ▁ER - G ol gi ▁Inter mediate ▁Com partment ▁( ER G IC ). ▁S cy l 1 ▁bind s ▁to ▁Co atom er ▁I ▁( CO PI ) ▁and ▁col ocal izes ▁with ▁beta - CO PI ▁and ▁ER G IC 5 3 . ▁si R NA ▁medi ated