si ▁women ▁in ▁West ▁India ▁have ▁the ▁milk ▁R N ase ▁level ▁marked ly ▁lower ▁than ▁in ▁other ▁groups , ▁and ▁their ▁breast ▁cancer ▁rate ▁is ▁three ▁times ▁higher ▁than ▁average . ▁Thus , ▁rib on uc leases ▁of ▁milk , ▁and ▁la ct o fer rin ▁in ▁particular , ▁might ▁play ▁an ▁important ▁role ▁in ▁path ogen esis . ▁ ▁L act o fer rin ▁re ceptor ▁The ▁la ct o fer rin ▁re ceptor ▁plays ▁an ▁important ▁role ▁in ▁the ▁internal ization ▁of ▁la ct o fer rin ; ▁it ▁also ▁facil it ates ▁absor ption ▁of ▁iron ▁ ions ▁by ▁la ct o fer rin . ▁It ▁was ▁shown ▁that ▁gene ▁expression ▁increases ▁with ▁age ▁in ▁the ▁du oden um ▁and ▁decre ases ▁in ▁the ▁jej un um . ▁The ▁moon light ing ▁g ly col yt ic ▁en zym e ▁g ly cer al de hy de - 3 - ph osph ate ▁de h ydro gen ase ▁( G AP D H ) ▁has ▁been ▁demonstrated ▁to ▁function ▁as ▁a ▁re ceptor ▁for ▁la ct o fer rin . ▁ ▁B one ▁activity ▁Rib on uc lease - en rich ed ▁la ct o fer rin ▁has ▁been ▁used ▁to ▁examine ▁how ▁la ct o fer rin ▁affect s ▁b one . ▁L act o fer rin ▁has ▁shown ▁to ▁have ▁positive ▁effects ▁on ▁b one ▁turn over . ▁It ▁has ▁a ided ▁in ▁decre asing ▁b one ▁res or ption ▁and ▁increasing ▁b one ▁formation . ▁This