ic ▁n erves ▁are ▁associated , ▁damage ▁to ▁the ▁circul atory , ▁re product ive , ▁or ▁dig est ive ▁systems , ▁among ▁others . ▁Over ▁ 6 0 % ▁of ▁di ab etic ▁patients ▁are ▁said ▁to ▁have ▁some ▁form ▁of ▁ne urop ath y , ▁however , ▁the ▁sever ity ▁ranges ▁dram atically . ▁Ne urop ath y ▁not ▁only ▁directly ▁causes ▁harm ▁and ▁damage ▁but ▁also ▁can ▁indirect ly ▁lead ▁to ▁such ▁problems ▁as ▁di ab etic ▁ul cer ations , ▁which ▁in ▁turn ▁can ▁lead ▁to ▁am put ations . ▁In ▁fact , ▁over ▁half ▁of ▁all ▁lower ▁lim b ▁am put ations ▁in ▁the ▁United ▁States ▁are ▁of ▁patients ▁with ▁di ab etes . ▁ ▁Through ▁the ▁use ▁of ▁the ▁N AA G ▁pe pt id ase ▁in hib itor ▁ 2 - P MP A , ▁N AA G ▁cle av age ▁was ▁in hib ited ▁and , ▁with ▁it , ▁program med ▁DR G ▁neur onal ▁cell ▁death ▁in ▁the ▁presence ▁of ▁high ▁gl uc ose ▁levels . ▁The ▁research ers ▁have ▁proposed ▁that ▁the ▁cause ▁of ▁this ▁is ▁N AA G ' s ▁ag on istic ▁activity ▁at ▁m G lu R 3 . ▁In ▁addition , ▁N AA G ▁also ▁“ prevent ed ▁gl uc ose - indu ced ▁in hib ition ▁of ▁neur ite ▁growth ” ▁( Ber ent - ▁Sp ill son , ▁et ▁al . ▁ 2 0 0 4 ). ▁Over all , ▁this ▁makes ▁GC PI II ▁in hib