▁why ▁ABC A 3 ▁d ys function ▁leads ▁to ▁severe ▁sur fact ant ▁met abol ism ▁d ys function . ▁ ▁Di agn osis ▁ ▁Types ▁▁ ▁Non - in vas ive ▁gen etic ▁testing ▁can ▁be ▁used ▁to ▁infer ▁possible ▁inter st it ial ▁lung ▁dis orders ▁caused ▁by ▁sur fact ant ▁met abol ism ▁d ys function . ▁Although ▁these ▁sequ encing ▁tests ▁can ▁take ▁up ▁to ▁several ▁weeks , ▁which ▁may ▁not ▁be ▁so ▁useful ▁in ▁case ▁of ▁ac ute ▁resp ir atory ▁problems ▁in ▁new born s . ▁Over la pping ▁phen ot ypes ▁of ▁sur fact ant ▁met abol ism ▁d ys function ▁and ▁other ▁inter st it ial ▁lung ▁dise ases ▁make ▁it ▁hard ▁to ▁propose ▁definit ive ▁diagn osis ▁for ▁sur fact ant ▁dis orders . ▁Over all ▁test ings , ▁family ▁history , ▁external ▁factors , ▁and ▁clin ical ▁present ations ▁should ▁all ▁be ▁considered ▁to ▁diagn ose ▁sur fact ant ▁met abol ism ▁d ys function . ▁Test ing ▁for ▁sur fact ant ▁met abol ism ▁d ys function ▁should ▁be ▁considered ▁for ▁new born s ▁with ▁diff use ▁lung ▁disease ▁or ▁hy po x emia , ▁especially ▁in ▁families ▁with ▁history ▁of ▁ne on atal ▁lung ▁dise ases ▁or ▁I LD ▁in ▁adult s . ▁Ne on atal ▁and ▁adult ▁on set ▁lung ▁dise ases ▁with ▁un found ▁causes ▁should ▁also ▁be ▁tested ▁early ▁for ▁sur fact ant ▁d ys function . ▁ABC A 3 ▁and ▁SP - B ▁d ys functions ▁manifest