▁as ▁well ▁as ▁the ▁significance ▁of ▁different ▁tum or ▁factors ▁and ▁st rom al ▁mole cules ▁in ▁tum or ▁invasion . ▁The ▁data ▁and ▁facts ▁collected ▁are ▁essential ▁to ▁the ▁understanding ▁of ▁how ▁the ▁patterns ▁of ▁cancer ▁cell ▁invasion ▁are ▁related ▁to ▁cancer ▁pro gression ▁and ▁ther apy ▁effic acy . ▁Con vin cing ▁evidence ▁is ▁provided ▁that ▁morph ological ▁manifest ations ▁of ▁the ▁invasion ▁patterns ▁are ▁character ized ▁by ▁a ▁variety ▁of ▁t issue ▁( t um or ) ▁structures . ▁The ▁results ▁of ▁our ▁own ▁studies ▁are ▁presented ▁to ▁show ▁the ▁association ▁of ▁breast ▁cancer ▁pro gression ▁with ▁intr atum oral ▁morph ological ▁heter ogene ity , ▁which ▁most ▁likely ▁reflect s ▁the ▁types ▁of ▁cancer ▁cell ▁migration ▁and ▁results ▁from ▁different ▁activities ▁of ▁cell ▁ad hes ion ▁mole cules ▁in ▁tum or ▁cells ▁of ▁distinct ▁morph ological ▁structures . ▁ ▁In vas ive ▁growth ▁and ▁met ast asis ▁as ▁manifest ation ▁of ▁cancer ▁m align ancy ▁The ▁results ▁of ▁numerous ▁experimental ▁and ▁clin ical ▁studies ▁of ▁m align ant ▁ne op las ms ▁have ▁indicated ▁that ▁invas ive ▁growth ▁and ▁met ast asis ▁are ▁the ▁main ▁manifest ations ▁of ▁tum or ▁pro gression , ▁which ▁represent ▁two ▁closely ▁related ▁processes . ▁ <0x09> ▁A ▁m align ant ▁tum or ▁is ▁character ized ▁by ▁the ▁possibility ▁to ▁implement ▁such ▁a ▁bi ological ▁phenomen on ▁as ▁the ▁met ast atic ▁cas cade ▁that ▁is ▁a ▁unique ▁multi - stage ▁“ program ” ▁where ▁cell ▁invasion ▁is ▁a ▁trigger ▁and ▁a ▁key ▁factor