▁and ▁the ▁ext rac ell ular ▁matrix , ▁therefore ▁imp eding ▁w ound ▁he aling ▁and ▁causing ▁destruction ▁of ▁period ont al ▁t issues . ▁R g p ▁is ▁responsible ▁for ▁el ic iting ▁the ▁host ▁infl am mat ory ▁response ▁via ▁the ▁p 3 8 α ▁M AP K ▁trans du ction ▁path way . ▁This ▁response ▁likely ▁cont ributes ▁to ▁the ▁infl am mat ory ▁nature ▁of ▁period ont itis ▁and ▁is ▁involved ▁in ▁t issue ▁and ▁b one ▁destruction . ▁ ▁G ing ip ains ▁have ▁been ▁associated ▁with ▁Al z heimer ' s ▁disease ▁( AD ). ▁G ing ip ains ▁were ▁discovered ▁from ▁T MA s ▁of ▁patients ▁exhib iting ▁AD ▁brain ▁path ology . ▁Both ▁R g p B ▁and ▁K bp ▁were ▁discovered ▁from ▁hi pp oc amp us ▁and ▁c ere br al ▁cor tex ▁of ▁AD ▁patients ▁and ▁were ▁found ▁to ▁be ▁associated ▁with ▁t au ▁load , ▁a ▁marker ▁for ▁AD ▁path ology ▁and ▁u bi quit in , ▁which ▁accum ul ates ▁in ▁t au ▁tang les ▁and ▁am y lo id ▁beta ▁pla ques ▁in ▁AD ▁brain . ▁P . ▁ging ival is ▁ 1 6 S ▁r R NA ▁was ▁also ▁discovered ▁in ▁the ▁c ere br al ▁cor tex ▁and ▁c sf ▁of ▁AD ▁bra ins . ▁P ret re at ment ▁with ▁ging ip ain ▁in hib itors ▁protected ▁neur on ▁cell ▁de grad ation ▁caused ▁by ▁administration ▁of ▁ging ip ains ▁in ▁mur ine ▁model . ▁