▁be ▁severe ▁and ▁result ▁in ▁card i ov asc ular ▁changes ▁such ▁as ▁an ▁increase ▁in ▁heart ▁rate . ▁Blood ▁in ▁the ▁ur ine ▁may ▁occur ▁due ▁to ▁the ▁l ysis ▁of ▁red ▁blood ▁cells . ▁General ▁system ic ▁signs ▁such ▁as ▁di arr he a , ▁an ore x ia , ▁and ▁weight ▁loss ▁may ▁also ▁be ▁present . ▁ ▁C aus es ▁Several ▁species ▁of ▁r icket ts ial ▁b acter ia ▁cause ▁an ap las mos is ▁in ▁r umin ants : ▁ ▁C attle : ▁ ▁An ap las ma ▁margin ale ▁- ▁found ▁world wide ▁ ▁An ap las ma ▁centrale ▁- ▁found ▁mainly ▁in ▁South ▁America , ▁Africa ▁and ▁the ▁Middle ▁East ▁ ▁She ep ▁and ▁go ats : ▁ ▁An ap las ma ▁o vis ▁- ▁found ▁world wide ▁ ▁Pre vention ▁V acc ines ▁against ▁an ap las mos is ▁are ▁available . ▁Car rier ▁animals ▁should ▁be ▁elimin ated ▁from ▁f lock s . ▁T ick ▁control ▁may ▁also ▁be ▁useful , ▁although ▁it ▁can ▁be ▁difficult ▁to ▁implement . ▁ ▁Tre at ment ▁The ▁most ▁effective ▁courses ▁of ▁treatment ▁are ▁do xy cy cl ine ▁( a ▁normal ▁do se ▁would ▁be ▁ 1 0 0   m g ▁every ▁ 1 2 ▁hours ▁for ▁adult s ), ▁rif amp in ▁and ▁lev of lo x ac in . ▁After ▁treatment ▁most ▁animals ▁become ▁resist ant ▁to ▁the ▁disease . ▁O xy t et racy cl ine ▁and ▁im id oc ar b