expression ▁had ▁the ▁reverse ▁effect . ▁ ▁LI MP - 2 ▁plays ▁other ▁roles ▁in ▁other ▁org ans . ▁Character istic ▁tub ular ▁protein uria ▁observed ▁in ▁LI MP - 2 ▁knock out ▁m ice ▁has ▁been ▁shown ▁to ▁be ▁due ▁to ▁a ▁failure ▁of ▁in ▁l ys os om al / end os om al ▁fusion , ▁thus ▁prote ins ▁re abs or bed ▁in ▁the ▁proxim al ▁tub ule ▁of ▁the ▁kid ney ▁are ▁not ▁properly ▁prote ol yz ed , ▁causing ▁the ▁protein uria . ▁Def ic iency ▁of ▁LI MP - 2 ▁in ▁m ice ▁was ▁also ▁reported ▁to ▁imp air ▁cell ▁memb rane ▁transport ▁processes ▁and ▁cause ▁pel vic ▁j unction ▁obst ruction , ▁de af ness , ▁and ▁peri pher al ▁ne urop ath y . ▁ ▁C lin ical ▁significance ▁▁ ▁In ▁patients ▁with ▁hy pert roph ic ▁card iom y op ath y ▁due ▁to ▁a ort ic ▁st en osis , ▁SC AR B 2 ▁m R NA ▁is ▁significantly ▁up reg ulated , ▁suggesting ▁that ▁LI MP - 2 ▁may ▁act ▁as ▁a ▁hy pert roph ic ▁marker . ▁ ▁Mut ations ▁in ▁SC AR B 2 ▁have ▁been ▁shown ▁to ▁cause ▁action ▁my oc lon us ▁ren al ▁failure ▁synd rome , ▁a ▁rare ▁synd rome ▁character ized ▁by ▁progress ive ▁ne uro log ical ▁disease ▁and ▁associated ▁with ▁protein uria , ▁kid ney ▁failure , ▁and ▁F ocal ▁segment al ▁gl omer ulos cl eros is . ▁ ▁Mut ations ▁in