▁is ▁the ▁“ primary ▁exc itat ory ▁ne uro trans mit ter ▁in ▁the ▁human ▁nerv ous ▁system ”, ▁particip ating ▁in ▁a ▁mult itude ▁of ▁brain ▁functions . ▁Over - st im ulation ▁and ▁- activ ation ▁of ▁gl ut am ate ▁re cept ors ▁as ▁well ▁as ▁“ dist urban ces ▁in ▁the ▁cell ular ▁mechan isms ▁that ▁protect ▁against ▁the ▁ad verse ▁consequences ▁of ▁phys i ological ▁gl ut am ate ▁re ceptor ▁activation ” ▁have ▁been ▁known ▁to ▁cause ▁neur on ▁damage ▁and ▁death , ▁which ▁have ▁been ▁associated ▁with ▁multiple ▁ne uro log ical ▁dise ases . ▁ ▁Due ▁to ▁the ▁range ▁of ▁gl ut am ate ▁function ▁and ▁presence , ▁it ▁has ▁been ▁difficult ▁to ▁create ▁gl ut am ater g ic ▁dru gs ▁that ▁do ▁not ▁neg atively ▁affect ▁other ▁necessary ▁functions ▁and ▁cause ▁unw anted ▁side - effect s . ▁N AA G ▁pe pt id ase ▁in hib ition ▁has ▁offered ▁the ▁possibility ▁for ▁specific ▁drug ▁target ing . ▁ ▁Specific ▁in hib itors ▁▁ ▁Since ▁its ▁promise ▁for ▁possible ▁ne uro log ical ▁disease ▁ther apy ▁and ▁specific ▁drug ▁target ing , ▁N AA G ▁pe pt id ase ▁in hib itors ▁have ▁been ▁widely ▁created ▁and ▁studied . ▁A ▁few ▁small ▁mole c ule ▁examples ▁are ▁those ▁that ▁follow : ▁ 2 - P MP A ▁and ▁analog ues ▁Th i ol ▁and ▁ind ole ▁th i ol ▁derivatives ▁H ydro x am ate ▁derivatives ▁Con formation ally ▁con str icted ▁di