▁( P PAR y ) ▁– ▁a ▁nuclear ▁h orm one ▁re ceptor ▁responsible ▁for ▁the ▁reg ulation ▁of ▁gen es ▁associated ▁with ▁ad ip ocy te ▁different iation , ▁including ▁GL UT 4 . ▁si R NA ▁sil encing ▁of ▁M AP 4 K 4 ▁ ▁appears ▁to ▁prevent ▁ins ul in ▁resistance , ▁rest oring ▁ins ul in ▁sens itivity ▁in ▁human ▁ske let al ▁mus cles ▁by ▁down - reg ulating ▁the ▁T NF - α ▁signal ing ▁cas cade ▁and ▁in hib its ▁the ▁T NF - α - indu ced ▁de ple tion ▁of ▁P PAR y ▁and ▁GL UT 4 . ▁Additionally , ▁mi R NA ▁sil encing ▁of ▁M AP 4 K 4 ▁in ▁pan cre atic ▁beta - cell s ▁con ferred ▁protection ▁against ▁T NF - α ▁repr ession ▁of ▁ins ul in ▁trans cription ▁and ▁secret ion , ▁further ▁confirm ing ▁that ▁M AP 4 K 4 ▁target ing ▁is ▁a ▁potential ▁strategy ▁for ▁di ab etes ▁prevent ion ▁and ▁treatment . ▁ ▁A ther os cl eros is ▁ ▁A ther os cl eros is ▁is ▁the ▁result ▁of ▁an ▁infl am mat ory ▁response ▁to ▁li pid - medi ated ▁v asc ular ▁damage . ▁It ▁has ▁been ▁identified ▁that ▁cy tok ines ▁such ▁as ▁T NF - α ▁indu ce ▁the ▁expression ▁of ▁pro - infl am mat ory ▁gen es ▁to ▁synth es ize ▁le uk ocy te ▁ad hes ion ▁mole cules ▁and ▁chem ok ines . ▁End