▁tra uma ▁in ▁u tero ▁may ▁also ▁be ▁a ▁strong ▁indicator ▁for ▁development ▁of ▁at opy . ▁ ▁The ▁term ▁at opy ▁was ▁co ined ▁by ▁C oca ▁and ▁Co oke ▁in ▁ 1 9 2 3 . ▁Many ▁phys icians ▁and ▁scient ists ▁use ▁the ▁term ▁" at opy " ▁for ▁any ▁Ig E - medi ated ▁reaction ▁( even ▁those ▁that ▁are ▁appropriate ▁and ▁proportional ▁to ▁the ▁ant igen ), ▁but ▁many ▁ped iat r icians ▁reserve ▁the ▁word ▁" at opy " ▁for ▁a ▁gen et ically ▁medi ated ▁pre dis position ▁to ▁an ▁excess ive ▁Ig E ▁reaction . ▁The ▁term ▁is ▁from ▁Greek ▁ ἀ τ ο π ί α ▁meaning ▁" the ▁state ▁of ▁being ▁out ▁of ▁place ", ▁" abs urd ity ". ▁ ▁Sign s ▁and ▁sympt oms ▁At op ic ▁sens it ization ▁is ▁considered ▁Ig E ▁posit ivity ▁or ▁pr ick ▁test ▁posit ivity ▁to ▁any ▁common ▁food ▁or ▁air ▁born ▁aller gen . ▁At op ic ▁conditions ▁are ▁considered : ▁at op ic ▁der mat itis , ▁all erg ic ▁rh init is ▁( h ay ▁fe ver ), ▁all erg ic ▁ast h ma . ▁The ▁lik elihood ▁of ▁having ▁ast h ma , ▁rh init is ▁and ▁at op ic ▁der mat itis ▁together ▁is ▁ 1 0 ▁times ▁higher ▁than ▁could ▁be ▁expected ▁by ▁chance . ▁ ▁At opy ▁is ▁more ▁common ▁among ▁individuals ▁with ▁a ▁number ▁of ▁different ▁conditions , ▁such ▁as ▁e os in oph il ic