▁contrast s ▁what ▁is ▁considered ▁" c oca ine - like " ▁aff inity ▁to ▁DAT ; ▁which ▁would ▁instead ▁keep ▁DAT ▁stable ▁in ▁an ▁open - to - out ▁con formation . ▁This ▁means ▁the ▁binding ▁of ▁many ▁dop am ine ▁re upt ake ▁in hib itors ▁is ▁at yp ical ▁of ▁c oca ine ' s ▁method ▁of ▁binding ▁to ▁DAT ▁and ▁significantly ▁diver ges ▁from ▁it . ▁ ▁" D if lu or op ine " ▁is ▁not ▁a ▁ph eny lt rop ane ▁but ▁actually ▁belongs ▁to ▁the ▁ben zat rop ine ▁family ▁of ▁DR Is . ▁Not ▁to ▁be ▁confused ▁for ▁the ▁" di ary l " - phen y lt rop anes . ▁ ▁In ▁certain ▁respect s ▁these ▁are ▁important ▁because ▁they ▁share ▁S AR ▁overlap ▁with ▁G BR ▁ 1 2 9 0 9 ▁and ▁related ▁anal ogs . ▁ ▁S AR s ▁have ▁shown ▁that ▁ 4 ′ , 4 ′ - d if lu or ination ▁is ▁an ▁excellent ▁way ▁to ▁boost ▁DAT ▁activity ▁of ▁ben zt rop ine , ▁and ▁gives ▁excellent ▁select ivity ▁over ▁the ▁S ERT ▁and ▁the ▁N ET . ▁ ▁Furthermore , ▁replacing ▁the ▁N - Me ▁with , ▁e . g . ▁n - phen yl pro py l ▁helps ▁to ▁bring ▁mus car in ic ▁activity ▁down ▁to ▁something ▁that ▁is ▁the ▁same ▁as ▁D RI ▁aff inity . ▁ ▁This ▁is ▁remarkable ▁considering ▁un mod ified ▁( native ) ▁ben zt rop ine ▁is ▁