in og ly cos ides , ▁and ▁gent am ic in ▁is ▁one ▁of ▁the ▁most ▁ne ph ro to xic ▁dru gs ▁of ▁this ▁class . ▁O ft ent imes , ▁ac ute ▁ne ph ro to x icity ▁is ▁revers ible , ▁but ▁it ▁may ▁be ▁fatal . ▁The ▁risk ▁of ▁ne ph ro to x icity ▁can ▁be ▁affected ▁by ▁the ▁do se , ▁frequency , ▁duration ▁of ▁ther apy , ▁and ▁concurrent ▁use ▁of ▁certain ▁medic ations , ▁such ▁as ▁NS A ID s , ▁di ure t ics , ▁c is pl atin , ▁cic los por in , ▁ce phal os por ins , ▁am ph oter ic in , ▁i od ide ▁contrast ▁media , ▁and ▁van com yc in . ▁ ▁Fact ors ▁that ▁increase ▁risk ▁of ▁ne ph ro to x icity ▁include : ▁ ▁In cre ased ▁age ▁ ▁Red u ced ▁ren al ▁function ▁ ▁P reg n ancy ▁ ▁Hyp othy roid ism ▁ ▁He p atic ▁d ys function ▁ ▁Volume ▁de ple tion ▁ ▁Met abol ic ▁ac idos is ▁ ▁S od ium ▁de ple tion ▁Kid ney ▁d ys function ▁is ▁monitor ed ▁by ▁meas uring ▁cre atin ine ▁in ▁the ▁blood , ▁electro ly te ▁levels , ▁ur ine ▁output , ▁presence ▁of ▁protein ▁in ▁the ▁ur ine , ▁ ▁and ▁concentr ations ▁of ▁other ▁chemical s , ▁such ▁as ▁u rea , ▁in ▁the ▁blood . ▁ ▁Inner ▁ear ▁ ▁About ▁ 1 1 %