AL eu ( U UR ). ▁The ▁u rid ine ▁at ▁the ▁ant ic odon ▁first ▁position ▁of ▁the ▁t R N AL eu ( U UR ) ▁is ▁normally ▁post - ▁trans cription ally ▁modified ▁to ▁ensure ▁correct ▁cod on ▁recognition . ▁Such ▁modification ▁is ▁known ▁as ▁t aur ine ▁modification , ▁which ▁is ▁decre ased ▁as ▁a ▁result ▁of ▁the ▁impro per ▁structure ▁of ▁the ▁t R N AL eu ( U UR ). ▁In correct ▁t R N AL eu ( U UR ) ▁structure ▁also ▁results ▁in ▁decre ased ▁am ino ac yl ation . ▁The ▁mut ation ▁has ▁also ▁been ▁shown ▁to ▁result ▁in ▁decre ased ▁function ▁of ▁the ▁t R NA ▁and ▁thus ▁protein ▁synth esis . ▁ ▁Met abol ic ▁characteristics ▁of ▁di ab etes ▁in ▁M ID D ▁ ▁The ▁A 3 2 4 3 G ▁mut ation ▁in ▁mit och ond rial ▁DNA ▁can ▁be ▁present ▁in ▁any ▁t issue , ▁however , ▁it ▁is ▁more ▁commonly ▁present ▁in ▁t issues ▁with ▁lower ▁rep lication ▁rates ▁such ▁as ▁mus cle . ▁The ▁presence ▁of ▁this ▁mut ation ▁can ▁lead ▁to ▁decre ased ▁o xygen ▁consumption ▁as ▁a ▁result ▁of ▁reduced ▁function ▁of ▁the ▁resp ir atory ▁chain ▁and ▁a ▁decrease ▁in ▁ox id ative ▁ph osph ory lation . ▁In ▁some ▁people , ▁this ▁reduction ▁in ▁function ▁of ▁the ▁resp ir atory ▁chain ▁is ▁suggested ▁to ▁be ▁caused ▁by ▁un bal anced ▁amounts ▁of ▁prote ins ▁that ▁are ▁encoded ▁by ▁mit och ond rial