par os cop ic ▁minim ally ▁ ▁invas ive ▁ ▁techniques ▁have ▁been ▁used ▁successfully . ▁ ▁Min im ally ▁invas ive ▁surg ical ▁techniques ▁remain ▁controvers ial ▁due ▁to ▁the ▁absence ▁of ▁long - term ▁data , ▁with ▁a ▁particular ▁concern ▁for ▁rates ▁of ▁rec urrence ▁and ▁per it one al ▁car cin om atos is . ▁▁▁ ▁Chem other apy ▁reg im ens ▁typically ▁include ▁the ▁drug ▁mit ot ane , ▁an ▁in hib itor ▁of ▁ster oid ▁synth esis , ▁which ▁is ▁to xic ▁to ▁cells ▁of ▁the ▁ad ren al ▁cor tex , ▁as ▁well ▁as ▁standard ▁c yt ot ox ic ▁dru gs . ▁A ▁ret ros pective ▁analysis ▁showed ▁a ▁surv ival ▁benefit ▁for ▁mit ot ane ▁in ▁addition ▁to ▁surg ery ▁when ▁compared ▁to ▁surg ery ▁alone . ▁ ▁The ▁two ▁most ▁common ▁reg im ens ▁are ▁c is pl atin , ▁do x or ub ic in , ▁et op os ide ▁( ED P ) ▁+ ▁mit ot ane , ▁and ▁stre pt oz ot oc in ▁+ ▁mit ot ane . ▁The ▁F IR M - ACT ▁trial ▁demonstrated ▁higher ▁rates ▁of ▁response ▁and ▁longer ▁pro gression - free ▁surv ival ▁with ▁ED P ▁+ ▁mit ot ane ▁than ▁with ▁stre pt oz ot oc in ▁+ ▁mit ot ane . ▁ ▁Pro gn osis ▁A CC , ▁generally , ▁car ries ▁a ▁poor ▁pro gn osis ▁and ▁is ▁unlike ▁most ▁tum ours ▁of ▁the ▁ad ren al ▁cor tex , ▁which ▁are