zym e ▁that ▁in ▁humans ▁is ▁encoded ▁by ▁the ▁F OL H 1 ▁( fol ate ▁hyd rol ase ▁ 1 ) ▁gene . ▁Human ▁GC PI I ▁contains ▁ 7 5 0 ▁am ino ▁ac ids ▁and ▁we igh s ▁approximately ▁ 8 4 ▁k Da . ▁ ▁GC PI I ▁ ▁is ▁a ▁z inc ▁metal lo enz yme ▁that ▁res ides ▁in ▁memb ran es . ▁Most ▁of ▁the ▁en zym e ▁res ides ▁in ▁the ▁ext rac ell ular ▁space . ▁GC PI I ▁is ▁a ▁class ▁II ▁memb rane ▁g ly cop rote in . ▁It ▁catal y zes ▁the ▁hydro ly s is ▁of ▁N - ac et yl as part yl gl ut am ate ▁( NA AG ) ▁to ▁gl ut am ate ▁and ▁N - ac et yl as part ate ▁( NA A ) ▁according ▁to ▁the ▁reaction ▁scheme ▁to ▁the ▁right . ▁ ▁Neu ros cient ists ▁primarily ▁use ▁the ▁term ▁NA AL AD ase ▁in ▁their ▁studies , ▁while ▁those ▁studying ▁fol ate ▁met abol ism ▁use ▁fol ate ▁hyd rol ase , ▁and ▁those ▁studying ▁pro state ▁cancer ▁or ▁on col ogy , ▁PS MA . ▁All ▁of ▁which ▁refer ▁to ▁the ▁same ▁protein ▁gl ut am ate ▁car box ype pt id ase ▁II . ▁ ▁Disc overy ▁ ▁GC PI I ▁is ▁mainly ▁expressed ▁in ▁four ▁t issues ▁of ▁the ▁body , ▁including ▁pro state ▁ep ith el ium , ▁the ▁proxim al ▁tub ules ▁of ▁the ▁kid