▁differ ▁chem ically , ▁but ▁col lagen ▁generally ▁forms ▁the ▁bulk ▁of ▁the ▁structure . ▁ ▁Through ▁the ▁interaction ▁of ▁cell ▁with ▁its ▁ext rac ell ular ▁matrix ▁( trans m itted ▁through ▁the ▁anch oring ▁mole cules ▁class ed ▁as ▁integr ins ) ▁there ▁forms ▁a ▁continuous ▁association ▁between ▁cell ▁interior , ▁cell ▁memb rane ▁and ▁ext rac ell ular ▁matrix ▁components ▁that ▁help ▁drive ▁various ▁cell ular ▁events ▁in ▁a ▁reg ulated ▁fashion . ▁W ound ▁he aling ▁is ▁a ▁local ized ▁event ▁involving ▁the ▁reaction ▁of ▁cells ▁to ▁the ▁damage ▁sust ained . ▁ ▁The ▁cells ▁break ▁down ▁dam aged ▁EC M ▁and ▁replace ▁it , ▁generally ▁increasing ▁in ▁number ▁to ▁react ▁to ▁the ▁harm . ▁The ▁process ▁is ▁activ ated , ▁though ▁perhaps ▁not ▁exclus ively , ▁by ▁cells ▁respond ing ▁to ▁fragments ▁of ▁dam aged ▁EC M , ▁and ▁the ▁rep airs ▁are ▁made ▁by ▁re ass emb ling ▁the ▁matrix ▁by ▁cells ▁growing ▁on ▁and ▁through ▁it . ▁Because ▁of ▁this ▁ext rac ell ular ▁matrix ▁is ▁often ▁considered ▁as ▁a ▁' con duct or ▁of ▁the ▁w ound ▁he aling ▁sym phony '. ▁In ▁the ▁In fl am mat ory ▁phase , ▁neut roph ils ▁and ▁macro ph ages ▁rec ruit ▁and ▁activ ate ▁fib ro bl asts ▁which ▁in ▁subsequent ▁gran ulation ▁phase ▁migr ate ▁into ▁the ▁w ound , ▁lay ing ▁down ▁new ▁col lagen ▁of ▁the ▁sub types ▁I ▁and ▁III . ▁ ▁In ▁the ▁initial ▁events ▁of ▁w ound ▁he aling ,