▁c oca ine ▁▁ ▁However ▁strict ▁analog ues ▁of ▁c oca ine ▁would ▁also ▁include ▁such ▁other ▁potential ▁combinations ▁as ▁phen acy lt rop anes ▁& ▁other ▁carbon ▁branch ed ▁rep lac ements ▁not ▁listed ▁above . ▁The ▁term ▁may ▁also ▁be ▁lo os ely ▁used ▁to ▁refer ▁to ▁dru gs ▁manufact ured ▁from ▁c oca ine ▁or ▁having ▁their ▁basis ▁as ▁a ▁total ▁synth esis ▁of ▁c oca ine , ▁but ▁modified ▁to ▁alter ▁their ▁effect ▁& ▁Q S AR . ▁These ▁include ▁both ▁int rac ell ular ▁sod ium ▁channel ▁block er ▁an a est het ics ▁and ▁stim ul ant ▁dop am ine ▁re upt ake ▁in hib itor ▁lig ands ▁( such ▁as ▁certain , ▁namely ▁trop ane - brid ged - ex c ised , ▁pi per id ines ). ▁Additionally , ▁research ers ▁have ▁supported ▁combin atorial ▁approaches ▁for ▁taking ▁the ▁most ▁prom ising ▁analog ues ▁currently ▁el uc id ated ▁and ▁mixing ▁them ▁to ▁the ▁end ▁of ▁discover ing ▁novel ▁& ▁eff ica cious ▁comp ounds ▁to ▁optimize ▁their ▁util ization ▁for ▁differ ing ▁distinct ▁specified ▁purposes . ▁ ▁Anal ogs ▁sens u ▁str ic to ▁ ▁C oca ine ▁S tere ois om ers ▁ ▁Where ▁the ▁ 2 D ▁diag rams ▁given ▁for ▁the ▁struct ural ▁anal ogs ▁below ▁do ▁not ▁indicate ▁s tere och em istry , ▁it ▁should ▁be ▁assumed ▁they ▁share ▁the ▁con formation ▁of ▁R - c oca ine , ▁unless ▁noted ▁otherwise . ▁ ▁The ▁natural ▁is omer ism