▁L act o fer rin , ▁a ▁component ▁of ▁inn ate ▁imm unity , ▁prevents ▁b acter ial ▁bio film ▁development . ▁The ▁loss ▁of ▁micro b ic idal ▁activity ▁and ▁increased ▁formation ▁of ▁bio film ▁due ▁to ▁decre ased ▁la ct o fer rin ▁activity ▁is ▁observed ▁in ▁patients ▁with ▁c yst ic ▁fib ros is . ▁In ▁c yst ic ▁fib ros is , ▁ant ib i otic ▁sus cept ibility ▁may ▁be ▁modified ▁by ▁la ct o fer rin ▁These ▁find ings ▁demonstrate ▁the ▁important ▁role ▁of ▁la ct o fer rin ▁in ▁human ▁host ▁defense ▁and ▁especially ▁in ▁lung . ▁L act o fer rin ▁with ▁hypoth i oc yan ite ▁has ▁been ▁granted ▁or phan ▁drug ▁status ▁by ▁the ▁E ME A ▁and ▁the ▁F DA . ▁ ▁N ec rot izing ▁enter oc ol itis ▁A ▁ 2 0 1 7 ▁C och rane ▁review ▁with ▁low ▁quality ▁suggests ▁that ▁or al ▁la ct o fer rin ▁with ▁or ▁without ▁prob i otic ▁decre ases ▁late ▁on set ▁of ▁se ps is ▁and ▁ne c rot izing ▁enter oc ol itis ▁( stage ▁II ▁or ▁III ) ▁in ▁pre term ▁inf ants ▁with ▁no ▁ad verse ▁effects . ▁ ▁In ▁diagn osis ▁L act o fer rin ▁levels ▁in ▁te ar ▁fluid ▁have ▁been ▁shown ▁to ▁decrease ▁in ▁dry ▁eye ▁dise ases ▁such ▁as ▁S jö gren ' s ▁synd rome . ▁A ▁rapid , ▁port able ▁test ▁util izing ▁micro fl uid ic ▁technology ▁has ▁been