▁ ▁east ▁north ▁east ▁of ▁Pel ag osa ▁Island , ▁Kingdom ▁of ▁the ▁Two ▁Sic il ies , ▁on ▁ 1 2 ▁January ▁ 1 8 2 0 ▁in ▁the ▁Adri atic ▁Sea , ▁north ▁of ▁G arg ano . ▁Captain ▁J . ▁Ferr and ▁, ▁the ▁car p enter , ▁and ▁three ▁se amen ▁d rown ed . ▁The ▁Chief ▁Officer ▁and ▁eleven ▁of ▁the ▁crew ▁reached ▁Man fred onia ▁after ▁two ▁days ▁and ▁night s ▁in ▁her ▁boats . ▁ ▁Cit ations ▁and ▁references ▁Cit ations ▁ ▁References ▁ ▁Category : 1 8 0 7 ▁ships ▁Category : Age ▁of ▁S ail ▁merchant ▁ships ▁of ▁England ▁Category : Mar itime ▁inc idents ▁in ▁January ▁ 1 8 2 0 <0x0A> </s> ▁S B - 2 7 7 , 0 1 1 A ▁is ▁a ▁drug ▁which ▁acts ▁as ▁a ▁pot ent ▁and ▁select ive ▁dop am ine ▁D 3 ▁re ceptor ▁ant agon ist , ▁which ▁is ▁around ▁ 8 0 - 1 0 0 x ▁select ive ▁for ▁D 3 ▁over ▁D 2 , ▁and ▁la cks ▁any ▁partial ▁ag on ist ▁activity . ▁ ▁S B - 2 7 7 , 0 1 1 A ▁is ▁used ▁in ▁the ▁study ▁of ▁add iction ▁to ▁stim ul ant ▁dru gs ▁such ▁as ▁nic ot ine ▁and ▁c oca ine . ▁Where ▁c oca ine ▁reduces ▁the ▁threshold ▁for ▁brain ▁elect rical ▁self - st im ulation ▁in ▁r ats , ▁an ▁indic ation ▁of ▁c oca ine ' s ▁reward