row th ▁arrest - specific ▁ 5 ▁is ▁a ▁non - prote in ▁coding ▁R NA ▁that ▁in ▁humans ▁is ▁encoded ▁by ▁the ▁G AS 5 ▁gene . ▁ ▁G AS 5 ▁non c oding ▁R NA , ▁which ▁accum ul ates ▁in ▁growth ▁arrested ▁cells , ▁acts ▁as ▁a ▁de co y ▁h orm one ▁response ▁element ▁for ▁the ▁gl uc oc ort ico id ▁re ceptor ▁( GR ) ▁and ▁hence ▁blocks ▁the ▁up reg ulation ▁of ▁gene ▁expression ▁by ▁activ ated ▁GR . ▁ ▁A ▁number ▁of ▁studies ▁have ▁linked ▁G AS 5 ▁to ▁apo pt osis ▁and ▁it ▁may ▁play ▁a ▁role ▁in ▁the ▁pro gression ▁of ▁some ▁types ▁of ▁cancer . ▁ ▁The ▁G AS 5 ▁intr ons ▁host ▁several ▁s no R NA ▁sequences , ▁including ▁SN ORD 8 1 , ▁SN ORD 4 7 , ▁SN ORD 8 0 , ▁SN ORD 7 9 , ▁SN ORD 7 8 , ▁SN ORD 4 4 , ▁SN ORD 7 7 , ▁SN ORD 7 6 , ▁SN ORD 7 5 ▁and ▁SN ORD 7 4 . ▁These ▁intr onic ▁sequences ▁are ▁more ▁conser ved ▁than ▁the ▁ex ons ▁of ▁the ▁host ▁gene , ▁these ▁sorts ▁of ▁gen es ▁are ▁often ▁called ▁" inside - out ▁gen es ". ▁ ▁It ▁was ▁recently ▁discovered ▁that ▁the ▁n ons ense - medi ated ▁de grad ation ▁path way ▁can ▁reg ulate ▁the ▁function ▁of ▁the ▁G AS 5 ▁in ▁m amm al ian ▁cells . ▁ ▁References ▁ ▁Further