▁a ▁variety ▁of ▁factors , ▁including ▁ne uro t roph ins , ▁and ▁also ▁transfer ▁essential ▁mole cules ▁across ▁to ▁ax ons . ▁ ▁Gen et ics ▁ ▁Schw ann ▁cell ▁formation ▁ ▁So x 1 0 ▁ ▁SO X 1 0 ▁is ▁a ▁trans cription ▁factor ▁active ▁during ▁emb ry onic ▁development ▁and ▁abund ant ▁evidence ▁indicates ▁that ▁it ▁is ▁essential ▁for ▁the ▁generation ▁of ▁gli al ▁line ages ▁from ▁tr unk ▁cr est ▁cells . ▁When ▁SO X 1 0 ▁is ▁in activ ated ▁in ▁m ice , ▁satellite ▁gl ia ▁and ▁Schw ann ▁cell ▁prec urs ors ▁fail ▁to ▁develop , ▁though ▁neur ons ▁are ▁generated ▁normally ▁without ▁issue . ▁In ▁the ▁absence ▁of ▁SO X 1 0 , ▁neural ▁cr est ▁cells ▁surv ive ▁and ▁are ▁free ▁to ▁generate ▁neur ons , ▁but ▁gli al ▁specification ▁is ▁blocked . ▁SO X 1 0 ▁might ▁influence ▁early ▁gli al ▁prec urs ors ▁to ▁respond ▁to ▁ne ure g ul in ▁ 1 ▁( see ▁below ). ▁ ▁Ne ure g ul in ▁ 1 ▁ ▁Ne ure g ul in ▁ 1 ▁( NR G 1 ) ▁acts ▁in ▁a ▁number ▁of ▁ways ▁to ▁both ▁promote ▁the ▁formation ▁and ▁ensure ▁the ▁surv ival ▁of ▁imm ature ▁Schw ann ▁cells . ▁During ▁emb ry onic ▁development , ▁NR G 1 ▁in hib its ▁the ▁formation ▁of ▁neur ons ▁from ▁neural ▁cr est ▁cells , ▁instead ▁contrib uting ▁to ▁neural ▁cr est ▁cells ▁being ▁led ▁down ▁a ▁path ▁to ▁gli ogen esis