▁fl ut am ide ▁in ▁men ▁with ▁ben ign ▁pro static ▁hyper pl asia ▁and ▁pro state ▁cancer ▁alone ▁and ▁in ▁combination ▁with ▁a ▁G n R H ▁ag on ist ▁have ▁been ▁performed . ▁ ▁Fl ut am ide ▁increases ▁test oster one ▁levels ▁by ▁ 5 - ▁to ▁ 1 0 - fold ▁in ▁g on ad ally ▁int act ▁male ▁r ats . ▁ ▁C Y P 1 7 A 1 ▁in hib ition ▁Fl ut am ide ▁and ▁hydro xy fl ut am ide ▁have ▁been ▁found ▁in ▁vit ro ▁to ▁in hib it ▁C Y P 1 7 A 1 ▁( 1 7 α - h ydro x yl ase / 1 7 , 2 0 - ly ase ), ▁an ▁en zym e ▁which ▁is ▁required ▁for ▁the ▁b ios yn thesis ▁of ▁and rog ens . ▁In ▁accord ance , ▁fl ut am ide ▁has ▁been ▁found ▁to ▁slightly ▁but ▁significantly ▁lower ▁and ro gen ▁levels ▁in ▁G n R H ▁analog ue - tre ated ▁male ▁pro state ▁cancer ▁patients ▁and ▁women ▁with ▁pol yc yst ic ▁ov ary ▁synd rome . ▁As ▁such , ▁fl ut am ide ▁is ▁a ▁weak ▁in hib itor ▁of ▁and ro gen ▁b ios yn thesis . ▁However , ▁the ▁clin ical ▁significance ▁of ▁this ▁action ▁may ▁be ▁limited ▁when ▁fl ut am ide ▁is ▁given ▁without ▁a ▁G n R H ▁analog ue ▁to ▁non - c astr ated ▁men , ▁as ▁the ▁medic ation ▁marked ly