▁was ▁indicated ▁by ▁a ▁decrease ▁in ▁the ▁levels ▁of ▁two ▁b one ▁res or ption ▁markers ▁( de ox yp y rid in oline ▁and ▁N - tel ope pt ide ) ▁and ▁an ▁increase ▁in ▁the ▁levels ▁two ▁b one ▁formation ▁markers ▁( ost e ocal cin ▁and ▁al kal ine ▁ph osph at ase ). ▁It ▁has ▁reduced ▁o ste oc last ▁formation , ▁which ▁sign ifies ▁a ▁decrease ▁in ▁pro - infl am mat ory ▁responses ▁and ▁an ▁increase ▁in ▁ ▁anti - infl am mat ory ▁responses ▁ ▁which ▁indicates ▁a ▁reduction ▁in ▁b one ▁res or ption ▁as ▁well . ▁ ▁Inter action ▁with ▁nucle ic ▁ac ids ▁One ▁of ▁the ▁important ▁properties ▁of ▁la ct o fer rin ▁is ▁its ▁ability ▁to ▁bind ▁with ▁nucle ic ▁ac ids . ▁The ▁fraction ▁of ▁protein ▁extracted ▁from ▁milk , ▁contains ▁ 3 . 3 % ▁R NA , ▁but , ▁the ▁protein ▁prefer ably ▁bind s ▁to ▁double - str and ed ▁DNA ▁rather ▁than ▁single - str and ed ▁DNA . ▁The ▁ability ▁of ▁la ct o fer rin ▁to ▁bind ▁DNA ▁is ▁used ▁for ▁its ▁isol ation ▁and ▁pur ification ▁using ▁aff inity ▁chrom at ography ▁with ▁columns ▁containing ▁imm obil ized ▁DNA - cont aining ▁sor b ents , ▁such ▁as ▁ag ar ose ▁with ▁the ▁imm obil ized ▁single - str and ed ▁DNA . ▁ ▁C lin ical ▁significance ▁ ▁Ant ib acter ial ▁activity ▁L act o fer rin ' s ▁primary ▁role