▁Mich al ka ▁sister s ▁co - w rote ▁the ▁song ▁with ▁Anton ina ▁Arm ato ▁and ▁Tim ▁James ▁of ▁production ▁du o ▁Rock ▁M af ia , ▁who ▁also ▁produced ▁the ▁track . ▁It ▁was ▁the ▁second ▁main stream ▁single ▁from ▁In to ▁the ▁R ush ▁and ▁fourth ▁overall ▁single , ▁released ▁to ▁radio ▁by ▁Hollywood ▁Records ▁on ▁June ▁ 2 7 , ▁ 2 0 0 6 . ▁" Ch em ical s ▁React " ▁served ▁as ▁the ▁group ' s ▁debut ▁international ▁release . ▁ ▁Release ▁and ▁promotion ▁ ▁The ▁song ▁was ▁recorded ▁in ▁ 2 0 0 6 ▁for ▁the ▁re issue ▁of ▁the ▁du o ' s ▁debut ▁album , ▁In to ▁the ▁R ush , ▁which ▁was ▁released ▁in ▁August ▁ 2 0 0 6 . ▁" Ch em ical s ▁React " ▁was ▁released ▁June ▁ 1 5 , ▁ 2 0 0 6 ▁as ▁the ▁fourth ▁overall ▁single ▁from ▁the ▁album ▁and ▁first ▁from ▁the ▁Del ux e ▁Edition . ▁Hollywood ▁Records ▁serv iced ▁the ▁song ▁to ▁contemporary ▁hit ▁radio ▁in ▁the ▁United ▁States ▁on ▁June ▁ 2 7 , ▁ 2 0 0 6 . ▁It ▁follows ▁" R ush " ▁as ▁the ▁album ' s ▁second ▁main stream ▁single . ▁An ▁extended ▁play ▁containing ▁five ▁tracks ▁and ▁three ▁music ▁videos ▁was ▁released ▁in ▁the ▁United ▁States ▁on ▁in ▁September ▁ 2 0 0 6 . ▁The ▁song ▁was ▁released ▁digit ally ▁in ▁Europe ▁in ▁May ▁ 2 0 0 7 , ▁their ▁first