( ▁especially ▁Al u ▁repe ats ). ▁ ▁The ▁function ▁of ▁A ▁to ▁I ▁editing ▁in ▁these ▁regions ▁is ▁thought ▁to ▁involve ▁creation ▁of ▁sp lice ▁sites ▁and ▁ret ention ▁of ▁R N As ▁in ▁the ▁nucle us , ▁among ▁others . ▁ ▁Location ▁▁ ▁The ▁pre - m R NA ▁of ▁G lu R - 5 ▁is ▁edited ▁at ▁one ▁position ▁at ▁the ▁Q / R ▁site ▁located ▁at ▁memb rane ▁region ▁ 2 ▁( M 2 ). ▁There ▁is ▁a ▁cod on ▁change ▁as ▁a ▁result ▁of ▁editing . ▁The ▁cod on ▁change ▁is ▁( CA G ) ▁ ▁Gl ut am ine ▁( Q ) ▁to ▁( CG G ) ▁ ▁an ▁Ar gin ine ▁( R ). ▁Like ▁G lu R - 6 ▁the ▁E CS ▁is ▁located ▁about ▁ 2 0 0 0 ▁nucle ot ides ▁down stream ▁of ▁the ▁editing ▁site . ▁ ▁Reg ulation ▁ ▁Edit ing ▁of ▁the ▁Q / R ▁site ▁is ▁development - ▁and ▁t issue - reg ulated . ▁Edit ing ▁in ▁the ▁sp inal ▁cord , ▁cor pus ▁call os um , ▁c ere bell um ▁is ▁ 5 0 %, ▁while ▁editing ▁in ▁the ▁Th al am us , ▁am yd ala , ▁hi pp oc amp us ▁is ▁about ▁ 7 0 %. ▁ ▁Con sequ ences ▁ ▁Str ucture ▁ ▁Edit ing ▁results ▁in ▁a ▁change ▁in ▁am ino ▁acid ▁in ▁the ▁second ▁memb rane ▁domain ▁of ▁the ▁re ceptor . ▁ ▁Function ▁ ▁The ▁editing ▁site ▁is