0 A 1 1 ▁via ▁si R NA ▁reduces ▁the ▁sister - chrom at id ▁exchange ▁and ▁the ▁vi ability ▁of ▁cells . ▁ ▁S 1 0 0 A 1 1 ▁in ▁path ologies ▁ ▁IL - 8 ▁and ▁T NF - alpha ▁indu ce ▁the ▁expression ▁and ▁release ▁of ▁S 1 0 0 A 1 1 ▁in ▁ch ond ro cy tes ▁in ▁culture ▁and ▁ex ogen ous ▁S 1 0 0 A 1 1 ▁causes ▁ch ond ro cy te ▁hy pert ro phy . ▁S 1 0 0 A 1 1 ▁could ▁play ▁a ▁role ▁in ▁maintain ing ▁low - grade ▁infl amm ation ▁in ▁o ste o arth rit is ▁and ▁in ▁its ▁pro gression . ▁ ▁Its ▁cell ular ▁local ization ▁is ▁associated ▁with ▁the ▁reg ulation ▁of ▁cell ▁growth ▁and ▁pro l ifer ation . ▁This ▁protein ▁is ▁normally ▁found ▁strictly ▁in ▁the ▁nucle us , ▁but ▁appears ▁in ▁the ▁cy top las m ▁in ▁cancer ▁cells . ▁S 1 0 0 A 1 1 ▁was ▁local ized ▁in ▁the ▁cy top las m ▁of ▁rest ing ▁human ▁ker atin ocy tes ▁in ▁vit ro . ▁ ▁It ▁has ▁been ▁shown ▁to ▁interact ▁with ▁the ▁R AGE ▁re ceptor , ▁which ▁is ▁also ▁a ▁re ceptor ▁for ▁ ▁other ▁S 1 0 0 ▁prote ins . ▁ ▁It ▁is ▁associated ▁with ▁low ▁or ▁high ▁production ▁in ▁many ▁different ▁types ▁of ▁can cers . ▁Its ▁over production ▁has ▁been ▁found , ▁for ▁example , ▁in ▁breast , ▁pan