state ▁volume ▁by ▁about ▁ 2 5 %, ▁which ▁is ▁compar able ▁to ▁the ▁reduction ▁achieved ▁with ▁the ▁ 5 α - re duct ase ▁in hib itor ▁fin aster ide . ▁Unfortunately , ▁it ▁has ▁been ▁associated ▁with ▁side ▁effects ▁in ▁these ▁studies ▁including ▁gy ne com ast ia ▁and ▁breast ▁tend ern ess ▁( in ▁about ▁ 5 0 % ▁of ▁patients ), ▁g astro int est inal ▁dist urban ces ▁such ▁as ▁n ause a , ▁di arr he a , ▁and ▁flat ul ence , ▁and ▁he pat ot ox icity , ▁although ▁sexual ▁function ▁including ▁lib ido ▁and ▁ere ct ile ▁pot ency ▁were ▁maintained . ▁ ▁Bre ast ▁cancer ▁Fl ut am ide ▁was ▁studied ▁for ▁the ▁treatment ▁of ▁advanced ▁breast ▁cancer ▁in ▁two ▁phase ▁II ▁clin ical ▁tri als ▁but ▁was ▁found ▁to ▁be ▁in effect ive . ▁Out ▁of ▁a ▁total ▁of ▁ 4 7   pat ients , ▁only ▁three ▁short - term ▁responses ▁occurred . ▁However , ▁the ▁patients ▁in ▁the ▁studies ▁were ▁selected ▁ir res pective ▁of ▁AR , ▁, ▁, ▁or ▁H ER 2 ▁status , ▁which ▁were ▁all ▁unknown . ▁ ▁Psych iat ric ▁dis orders ▁Fl ut am ide ▁has ▁been ▁studied ▁in ▁the ▁treatment ▁of ▁bul im ia ▁nerv osa ▁in ▁women . ▁ ▁Fl ut am ide ▁was ▁found ▁to ▁be ▁effective ▁in ▁the ▁treatment ▁of ▁obs ess ive – comp uls ive ▁dis order ▁( O CD ) ▁in ▁men ▁with ▁com orb id ▁T ou