▁relationship ▁from ▁the ▁rest ▁of ▁the ▁family . ▁He ▁is ▁only ▁seen ▁in ▁a ▁couple ▁of ▁episodes , ▁and ▁dies ▁in ▁a ▁car ▁accident ▁late ▁in ▁Season ▁ 3 . ▁ ▁Natal ie ▁Mar ston ▁as ▁Mel issa ▁P ry or : ▁Ted ' s ▁ 1 8 - year - old ▁daughter , ▁nie ce ▁of ▁Jack ▁and ▁P ete . ▁She ▁entered ▁V ass ar ▁College ▁in ▁the ▁fall ▁of ▁ 1 9 6 6 . ▁ ▁John ▁J . ▁" T rip " ▁P ry or ▁III : ▁J J ▁and ▁Beth ' s ▁son , ▁born ▁in ▁November ▁ 1 9 6 5 ▁during ▁the ▁third ▁season . ▁ ▁Ad ina ▁Por ter ▁as ▁G wen ▁Walker : ▁Henry ' s ▁wife ▁and ▁a ▁house keeper , ▁who ▁died ▁in ▁Season ▁ 2 ▁of ▁cancer . ▁ ▁A ys ia ▁Pol k ▁as ▁Ang ela ▁Walker : ▁Henry ▁and ▁G wen ' s ▁daughter , ▁roughly ▁Pat ty ' s ▁age . ▁ ▁Keith ▁Robinson ▁as ▁Nathan ▁Walker : ▁Henry ' s ▁out sp oken ▁nep hew . ▁Sp ent ▁some ▁time ▁in ▁j ail ; ▁eventually ▁re h abil itated ▁himself ▁and ▁now ▁oper ates ▁a ▁delivery ▁service . ▁ ▁Jam ie ▁El man ▁as ▁Luke ▁F ole y : ▁A ▁record ▁store ▁cl erk . ▁Meg ' s ▁boy friend ▁in ▁the ▁first ▁season ; ▁after ▁they ▁broke ▁up , ▁Luke ▁and ▁Ro x anne ▁developed ▁a ▁relationship ▁and ▁began ▁living ▁together ▁in ▁the ▁third ▁season .