▁of ▁solid ▁tum ors ▁including ▁the ▁kid ney , ▁breast ▁and ▁colon . ▁ ▁In ▁terms ▁of ▁potential ▁to xic ities , ▁knock out ▁animals ▁were ▁normal ▁on ▁most ▁tests , ▁which ▁reduces ▁somewhat ▁concerns ▁about ▁to x icity ▁in ▁target ing ▁PS MA . ▁In ▁the ▁C NS , ▁PS MA ▁is ▁present ▁only ▁in ▁a ▁sub - set ▁of ▁gli al ▁cells , ▁again ▁suggesting ▁that ▁to x in ▁target ing ▁would ▁likely ▁have ▁minimal ▁to x icity ▁to ▁the ▁host ▁even ▁if ▁the ▁blood – bra in ▁bar rier ▁were ▁not ▁int act . ▁ ▁Ne uro trans mit ter ▁de grad ation ▁▁ ▁For ▁those ▁studying ▁neural ▁based ▁dise ases , ▁N AA G ▁is ▁one ▁of ▁the ▁three ▁most ▁pre val ent ▁ne uro trans mit ters ▁found ▁in ▁the ▁central ▁nerv ous ▁system ▁and ▁when ▁it ▁catal y zes ▁the ▁reaction ▁to ▁produce ▁gl ut am ate ▁it ▁is ▁also ▁producing ▁another ▁ne uro trans mit ter . ▁Gl ut am ate ▁is ▁a ▁common ▁and ▁abund ant ▁exc itat ory ▁ne uro trans mit ter ▁in ▁the ▁central ▁nerv ous ▁system ; ▁however , ▁if ▁there ▁is ▁too ▁much ▁gl ut am ate ▁transmission , ▁this ▁can ▁kill ▁or ▁at ▁least ▁damage ▁neur ons ▁and ▁has ▁been ▁imp licated ▁in ▁many ▁ne uro log ical ▁dise ases ▁and ▁dis orders ▁therefore ▁the ▁balance ▁that ▁N AA G ▁pe pt id ase ▁cont ributes ▁to ▁is ▁quite ▁important . ▁ ▁Pot ential ▁th era pe ut ic