ent ▁activity ▁of ▁function ing ▁structures ” ▁( K ry sh an ov sk ii , ▁ 1 9 7 3 ; ▁K ry sh an ov sk ii , ▁ 1 9 7 4 ). ▁According ▁to ▁this ▁law , ▁functional ▁units ▁of ▁act ively ▁function ing ▁t issue ▁( or ▁cells ) ▁form ▁two ▁populations ▁where ▁one ▁is ▁in ▁“ int ensive ▁function ing ” ▁state ▁and ▁the ▁other ▁one ▁– ▁is ▁in ▁“ rest ing ” ▁state . ▁There at ▁the ▁“ rest ” ▁is ▁not ▁a ▁pass ive ▁state ▁since ▁there ▁active ▁re par ation ▁of ▁cell ular ▁structures ▁occurs ▁dam aged ▁in ▁the ▁course ▁of ▁special ized ▁functions ▁performing ▁by ▁cells . ▁“ Inter mitt ent ” ▁pattern ▁of ▁t issue ▁cells ▁special ized ▁functions ▁real ization ▁is ▁that ▁the ▁cells ▁pass ▁from ▁one ▁population ▁to ▁another ▁when ▁the ▁t issue ▁is ▁in ▁int ensive ▁function ing ▁mode . ▁In ▁such ▁a ▁way ▁the ▁cells ▁dam aged ▁in ▁consequence ▁of ▁int ensive ▁function ing ▁gain ▁an ▁off ing ▁to ▁recover ▁in ▁“ rest ing ” ▁population . ▁Meanwhile , ▁recovered ▁cells ▁pass ▁from ▁the ▁“ rest ing ” ▁population ▁into ▁“ int ens ively ▁function ing ” ▁one . ▁It ▁is ▁safe ▁to ▁say ▁that ▁such ▁organization ▁of ▁t issue ▁function ing ▁fav ors ▁stability ▁of ▁its ▁cells ▁functions ▁performance . ▁Yet , ▁the ▁mechan isms ▁which ▁reg ulate ▁cells ▁passage ▁from ▁one ▁population ▁to ▁another ▁on ▁intr at issue ▁level ▁are ▁unknown . ▁ ▁Consider ing ▁the