og lu , ▁et ▁al ., ▁sought ▁to ▁investigate ▁connections ▁between ▁ox id ative ▁stress ▁gen es , ▁including ▁GP X 1 , ▁and ▁Pan ic ▁Dis order , ▁an ▁anx iety ▁dis order ▁character ized ▁by ▁random ▁and ▁unexpected ▁attacks ▁of ▁inten se ▁fear . ▁Although ▁the ▁GP X 1 ▁Pro 1 9 8 Le u ▁polym orphism , ▁in ▁general , ▁did ▁not ▁significantly ▁correlate ▁with ▁pan ic ▁dis order ▁risk , ▁the ▁study ▁found ▁a ▁pla us ible ▁association ▁of ▁the ▁C ▁alle le ▁of ▁the ▁GP X 1 ▁Pro 1 9 8 Le u ▁polym orphism , ▁found ▁to ▁be ▁more ▁frequent ▁in ▁the ▁female ▁coh ort , ▁with ▁P D ▁development . ▁ ▁Er gen ▁and ▁colle agues ▁analyz ed ▁gene ▁expression ▁of ▁ox id ative ▁stress ▁gen es , ▁specifically ▁GP X 1 , ▁in ▁col ore ct al ▁tum ors ▁in ▁comparison ▁to ▁health y ▁col ore ct al ▁t issues . ▁EL IS A ▁was ▁util ized ▁to ▁quant ify ▁GP X 1 ▁protein ▁expression ▁levels ▁in ▁both ▁t issue ▁types , ▁highlight ing ▁a ▁ 2 - fold ▁decrease ▁in ▁tum or ▁t issue ▁( p < 0 . 0 5 ). ▁ ▁In ▁es oph age al ▁cancer , ▁Chen ▁and ▁colle agues ▁found ▁that ▁vit amin ▁D , ▁a ▁known ▁suppress or ▁of ▁GP X 1 ▁expression ▁via ▁the ▁N F - κ B ▁signal ing ▁path way , ▁could ▁help ▁to ▁decrease ▁the ▁pro l ifer ative , ▁mig rat ory