▁it ▁begins ▁to ▁form ▁the ▁phase ▁of ▁met abol ism ▁stim ulation . ▁Str ong ▁dam aging ▁influ ences ▁initi ate ▁the ▁C UR D ▁phase ▁of ▁met abol ism ▁in hib ition ▁in ▁the ▁cell . ▁ ▁According ▁to ▁the ▁T AS ▁concept , ▁the ▁protect ive ▁effect ▁of ▁the ▁t issue ▁stress ▁is ▁realized ▁in ▁the ▁case ▁of ▁forming ▁of ▁C UR D ▁met abol ism ▁stim ulation ▁phase ▁by ▁T AS ▁effect ors ▁as ▁a ▁result ▁of ▁acceleration ▁of ▁re par ative ▁processes ▁in ▁the ▁dam aged ▁cell . ▁In ▁the ▁process ▁of ▁forming ▁of ▁C UR D ▁phase ▁of ▁met abol ism ▁in hib ition ▁by ▁the ▁above ▁effect ors ▁the ▁protect ive ▁influence ▁of ▁t issue ▁stress ▁develop s ▁a ▁result ▁of ▁cell ▁react ivity ▁decrease ▁in ▁response ▁to ▁the ▁external ▁dam aging ▁influ ences . ▁ ▁The ▁place ▁of ▁the ▁t issue ▁stress ▁in ▁line ▁of ▁the ▁un specific ▁adapt ive ▁re actions ▁The ▁main ▁feature ▁of ▁the ▁t issue ▁stress ▁is ▁its ▁formation ▁with ▁participation ▁of ▁the ▁t issues pec ific ▁effect ors ▁of ▁intr at issue ▁inter cell ular ▁interactions ▁– ▁com ut ons , ▁ch al ones ▁and ▁contact ins , ▁which ▁are ▁produced ▁by ▁the ▁cells ▁of ▁a ▁t issue ▁under ▁a ▁str essor ' s ▁influence . ▁This ▁distingu ishes ▁the ▁t issue ▁stress ▁from ▁the ▁general ▁adapt ive ▁synd rome , ▁which ▁is ▁realized ▁via ▁h orm ones ▁– ▁effect ors ▁of ▁inter organ ▁interactions ▁( see ▁Str ess ▁( bi