▁and ▁imp a ired ▁IF N ▁a , ▁b , ▁g ▁and ▁IL 2 7 ▁responses ▁are ▁diagn osed . ▁In ▁partial ▁form ▁there ▁can ▁also ▁be ▁found ▁high ▁levels ▁of ▁IF N g ▁in ▁blood ▁ser um . ▁When ▁tested ▁from ▁whole ▁blood , ▁mon ocy tes ▁do ▁not ▁respond ▁to ▁B CG ▁and ▁IF N g ▁dos es ▁with ▁IL - 1 2 ▁production . ▁In ▁complete ▁re cess ive ▁form ▁there ▁is ▁a ▁very ▁low ▁response ▁to ▁anti - vir al ▁and ▁ant im yc ot ical ▁medic ation . ▁Second , ▁partial ▁ST AT 1 ▁def ic iency ▁can ▁also ▁be ▁an ▁aut os om al ▁dominant ▁mut ation ; ▁phen ot yp ically ▁causing ▁imp a ired ▁IF N g ▁responses ▁and ▁causing ▁patients ▁to ▁suffer ▁with ▁select ive ▁int rac ell ular ▁b acter ial ▁dise ases ▁( MS MD ) ▁ ▁In ▁knock - out ▁m ice ▁prepared ▁in ▁the ▁ 9 0 s , ▁a ▁low ▁amount ▁of ▁CD 4 + ▁and ▁CD 2 5 + ▁regul atory ▁T - cell s ▁and ▁almost ▁no ▁IF Na , ▁b ▁and ▁g ▁response ▁was ▁discovered , ▁which ▁lead ▁to ▁par as ital , ▁vir al ▁and ▁b acter ial ▁in fe ctions . ▁The ▁very ▁first ▁reported ▁case ▁of ▁ST AT 1 ▁def ic iency ▁in ▁human ▁was ▁an ▁aut os om al ▁dominant ▁mut ation ▁and ▁patients ▁were ▁showing ▁prop ens ity ▁to ▁my c ob acter ial ▁in fe ctions . ▁Another ▁case ▁reported