▁applications ▁ ▁Function ▁in ▁the ▁brain ▁▁ ▁GC PI I ▁has ▁been ▁shown ▁to ▁both ▁indirect ly ▁and ▁directly ▁increase ▁the ▁concentration ▁of ▁gl ut am ate ▁in ▁the ▁ext rac ell ular ▁space . ▁GC PI I ▁directly ▁cle aves ▁N AA G ▁into ▁N AA ▁and ▁gl ut am ate . ▁N AA G ▁has ▁been ▁shown , ▁in ▁high ▁concentration , ▁to ▁indirect ly ▁in hib it ▁the ▁release ▁of ▁neut ro trans mit ters , ▁such ▁as ▁G AB A ▁and ▁gl ut am ate . ▁It ▁does ▁this ▁through ▁interaction ▁with ▁and ▁activation ▁of ▁pres yn apt ic ▁group ▁II ▁m G lu R s . ▁Thus , ▁in ▁the ▁presence ▁of ▁N AA G ▁pe pt id ase , ▁the ▁concentration ▁of ▁N AA G ▁is ▁kept ▁in ▁check , ▁and ▁gl ut am ate ▁and ▁G AB A , ▁among ▁other ▁ne uro trans mit ters , ▁are ▁not ▁in hib ited . ▁ ▁Research ers ▁have ▁been ▁able ▁to ▁show ▁that ▁effective ▁and ▁select ive ▁GC PI I ▁in hib itors ▁are ▁able ▁to ▁decrease ▁the ▁brain ' s ▁levels ▁of ▁gl ut am ate ▁and ▁even ▁provide ▁protection ▁from ▁apo pt osis ▁or ▁de grad ation ▁of ▁brain ▁neur ons ▁in ▁many ▁animal ▁models ▁of ▁stroke , ▁am y ot roph ic ▁later al ▁s cl eros is , ▁and ▁ne urop ath ic ▁pain . ▁This ▁in hib ition ▁of ▁these ▁N AA G ▁pe pt id ases , ▁sometimes ▁referred ▁to ▁as