▁This ▁process ▁has ▁two ▁types : ▁primary ▁f ibr in ol ysis ▁and ▁secondary ▁f ibr in ol ysis . ▁ ▁The ▁primary ▁type ▁is ▁a ▁normal ▁body ▁process , ▁whereas ▁secondary ▁f ibr in ol ysis ▁is ▁the ▁break down ▁of ▁cl ots ▁due ▁to ▁a ▁medicine , ▁a ▁medical ▁dis order , ▁or ▁some ▁other ▁cause . ▁ ▁In ▁f ibr in ol ysis , ▁a ▁f ibr in ▁cl ot , ▁the ▁product ▁of ▁co ag ulation , ▁is ▁broken ▁down . ▁Its ▁main ▁en zym e ▁pl as min ▁cut s ▁the ▁f ibr in ▁mesh ▁at ▁various ▁places , ▁leading ▁to ▁the ▁production ▁of ▁circul ating ▁fragments ▁that ▁are ▁cleared ▁by ▁other ▁prote ases ▁or ▁by ▁the ▁kid ney ▁and ▁li ver . ▁ ▁Phys i ology ▁ ▁Pl as min ▁is ▁produced ▁in ▁an ▁in active ▁form , ▁pl as min ogen , ▁in ▁the ▁li ver . ▁Although ▁pl as min ogen ▁cannot ▁cle ave ▁f ibr in , ▁it ▁still ▁has ▁an ▁aff inity ▁for ▁it , ▁and ▁is ▁incorpor ated ▁into ▁the ▁cl ot ▁when ▁it ▁is ▁formed . ▁ ▁T issue ▁pl as min ogen ▁activ ator ▁( t - PA ) ▁and ▁u ro kin ase ▁are ▁the ▁agents ▁that ▁convert ▁pl as min ogen ▁to ▁the ▁active ▁pl as min , ▁thus ▁allowing ▁f ibr in ol ysis ▁to ▁occur . ▁t - PA ▁is ▁released ▁into ▁the ▁blood ▁very ▁slowly ▁by ▁the ▁dam aged ▁end oth el ium ▁of ▁the