▁of ▁invasion ▁and ▁mit otic ▁activity ▁help ▁differenti ate ▁small ▁can cers ▁from ▁ad ren oc ort ical ▁ad en omas . ▁Several ▁relatively ▁rare ▁variants ▁of ▁A CC ▁include : ▁▁ ▁On c oc yt ic ▁ad ren al ▁cort ical ▁car cin oma ▁ ▁My x oid ▁ad ren al ▁cort ical ▁car cin oma ▁ ▁Car c inos ar com a ▁ ▁A den os qu am ous ▁ad ren oc ort ical ▁car cin oma ▁ ▁Clear ▁cell ▁ad ren al ▁cort ical ▁car cin oma ▁ ▁D iffer ential ▁diagn osis ▁D iffer ential ▁diagn osis ▁includes : ▁▁ ▁Ad ren oc ort ical ▁ad en oma ▁ ▁Ren al ▁cell ▁car cin oma ▁ ▁P he och rom oc yt oma ▁ ▁He pat oc ell ular ▁car cin oma ▁ ▁Tre at ment ▁The ▁only ▁cur ative ▁treatment ▁is ▁complete ▁surg ical ▁exc ision ▁of ▁the ▁tum or , ▁which ▁can ▁be ▁performed ▁even ▁in ▁the ▁case ▁of ▁invasion ▁into ▁large ▁blood ▁vessels , ▁such ▁as ▁the ▁ren al ▁ve in ▁or ▁inferior ▁v ena ▁c ava . ▁The ▁ 5 - year ▁surv ival ▁rate ▁after ▁successful ▁surg ery ▁is ▁ 5 0 – 6 0 %, ▁but ▁unfortunately , ▁many ▁patients ▁are ▁not ▁surg ical ▁candidates . ▁Rad iation ▁ther apy ▁and ▁radio fre quency ▁ab lation ▁may ▁be ▁used ▁for ▁pal li ation ▁in ▁patients ▁who ▁are ▁not ▁surg ical ▁candidates . ▁ ▁Both ▁open ▁ ▁ad ren ale ct omy ▁and ▁la