erm al ▁and ▁end oth el ial ▁bas ement ▁memb rane ▁also ▁contain ▁l amin in , ▁per le can ▁and ▁n id ogen . ▁H yal ur onic ▁acid , ▁a ▁pure ▁g ly cos amin og ly can ▁component ▁is ▁found ▁in ▁high ▁amounts ▁in ▁dam aged ▁or ▁growing ▁t issues . ▁It ▁stim ul ates ▁cy tok ine ▁production ▁by ▁macro ph ages ▁and ▁thus ▁prom otes ▁ang i ogen esis . ▁In ▁normal ▁skin ▁ch ond roit in ▁sul f ate ▁prote og ly can ▁is ▁mainly ▁found ▁in ▁the ▁bas ement ▁memb rane ▁but ▁in ▁he aling ▁w ounds ▁they ▁are ▁up ▁reg ulated ▁throughout ▁the ▁gran ulation ▁t issue ▁especially ▁during ▁second ▁week ▁of ▁w ound ▁repair , ▁when ▁they ▁provide ▁a ▁temporary ▁matrix ▁with ▁highly ▁hyd r ative ▁capacity . ▁Binding ▁of ▁growth ▁factors ▁is ▁clearly ▁an ▁important ▁role ▁of ▁per le can ▁in ▁w ound ▁he aling ▁and ▁ang i ogen esis . ▁Po or ▁w ound ▁he aling ▁in ▁di ab etes ▁m ell it us ▁may ▁be ▁related ▁to ▁per le can ▁expression . ▁High ▁levels ▁of ▁gl uc ose ▁can ▁decrease ▁per le can ▁expression ▁in ▁some ▁cells ▁probably ▁through ▁trans cription al ▁and ▁post - trans cription al ▁modification . ▁W ound ▁he aling ▁phases ▁especially , ▁gran ulation , ▁re - ep ith el ization ▁and ▁rem od eling ▁exhib it ▁controlled ▁turn over ▁of ▁ext rac ell ular ▁matrix ▁components . ▁ ▁Alter ed ▁met abol ism ▁Di ab