▁example , ▁Ro 1 5 - 4 5 1 3 ) ▁or ▁even ▁conv uls ive ▁and ▁an xi ogen ic ▁effects ▁( certain ▁beta - car bol ines ). ▁ ▁G ▁protein - cou ple d ▁re ceptor ▁inverse ▁ag on ists ▁▁ ▁Two ▁known ▁end ogen ous ▁inverse ▁ag on ists ▁are ▁the ▁Ag out i - related ▁pe pt ide ▁( Ag R P ) ▁and ▁its ▁associated ▁pe pt ide ▁Ag out i ▁sign alling ▁pe pt ide ▁( AS IP ). ▁Ag R P ▁and ▁AS IP ▁appear ▁naturally ▁in ▁humans ▁and ▁bind ▁mel an oc ort in ▁re cept ors ▁ 4 ▁and ▁ 1 ▁( Mc 4 R ▁and ▁Mc 1 R ), ▁respectively , ▁with ▁nan om olar ▁aff in ities . ▁ ▁The ▁op io id ▁ant agon ists ▁n al ox one ▁and ▁n alt re x one ▁are ▁also ▁partial ▁inverse ▁ag on ists ▁at ▁mu ▁op io id ▁re cept ors . ▁ ▁Near ly ▁all ▁anti h ist am ines ▁acting ▁at ▁H 1 ▁re cept ors ▁and ▁H 2 ▁re cept ors ▁have ▁been ▁shown ▁to ▁be ▁inverse ▁ag on ists . ▁ ▁The ▁beta ▁block ers ▁car ved il ol ▁and ▁bu c ind ol ol ▁have ▁been ▁shown ▁to ▁be ▁low ▁level ▁inverse ▁ag on ists ▁at ▁beta ▁ad reno cept ors . ▁ ▁See ▁also ▁ ▁Ag on ist ▁Re ceptor ▁ant agon ist ▁ ▁References ▁ ▁External ▁links ▁▁▁ ▁In verse ▁Ag on ists :