▁food ▁consumption ▁( r ats ▁and ▁rabb its ▁only ) ▁and ▁occas ional ▁vom iting ▁and / or ▁di arr ho ea ▁( d ogs , ▁ 1 2 0 ▁and ▁ 2 0 0   m g / kg ▁body weight ▁( b w )) ▁following ▁high ▁or al ▁dos es . ▁No ▁treatment - related ▁effects ▁on ▁vom iting ▁or ▁di arr ho ea ▁were ▁noted ▁following ▁or al ▁dos es ▁of ▁up ▁to ▁ 3 1 . 5   m g / kg ▁b w ▁in ▁the ▁p iv otal ▁target ▁animal ▁safety ▁study , ▁nor ▁in ▁the ▁EU ▁field ▁trial . ▁ ▁m ild ▁g astro int est inal ▁effects ▁( v om iting , ▁di arr ho ea ), ▁pr ur it us , ▁le th arg y , ▁an ore x ia , ▁and ▁ne uro log ical ▁signs ▁( conv uls ions , ▁at ax ia ▁and ▁mus cle ▁trem ors ) ▁have ▁been ▁reported ▁in ▁less ▁than ▁ 0 . 1 % ▁of ▁ 1 0 , 0 0 0 ▁animals ▁treated , ▁including ▁isolated ▁reports , ▁most ▁reported ▁ad verse ▁re actions ▁being ▁self - lim iting ▁and ▁of ▁short ▁duration , ▁ ▁( in ▁combination ▁with ▁mil b emy cin ▁ox ime ): ▁vom iting , ▁di arr ho ea , ▁le th arg y , ▁an ore x ia , ▁and ▁pr ur it us ▁were ▁observed ▁in ▁ 0 . 2 ▁to ▁ 1 % ▁of ▁ 1 0 , 0