▁single ▁pro be ▁are ▁that ▁it ▁allows ▁for ▁the ▁developing ▁of ▁a ▁high ▁through put ▁device . ▁ ▁A ▁high ▁through put ▁surface ▁t ension ▁device ▁can ▁be ▁used ▁for ▁form ulation ▁in ▁real ▁time ▁for ▁understanding ▁the ▁pen etr ation ▁of ▁dru gs ▁in ▁the ▁blood – bra in ▁bar rier ▁( BB B ), ▁understanding ▁the ▁sol ub ility ▁of ▁dru gs , ▁development ▁of ▁a ▁screen ▁to ▁test ▁a ▁dru gs ▁to x icity , ▁determ ining ▁the ▁phys ico chem ical ▁properties ▁of ▁ox id ized ▁ph osph ol ip ids , ▁and ▁development ▁of ▁new ▁sur fact ant / pol ym ers . ▁ ▁Pen etr ation ▁of ▁dru gs ▁in ▁the ▁B BB ▁ ▁The ▁phys ico chem ical ▁profil ing ▁of ▁poor ly ▁sol ub le ▁drug ▁candidates ▁performed ▁using ▁a ▁HT S ▁surface ▁t ension ▁device . ▁ ▁All owed ▁prediction ▁of ▁pen etr ation ▁through ▁the ▁blood – bra in ▁bar rier . ▁ ▁Development ▁of ▁a ▁screen ▁to ▁test ▁a ▁dru gs ▁to x icity ▁ ▁A ▁correlation ▁with ▁drug - lip id - comple xes ▁were ▁correl ated ▁with ▁high - through put ▁surface ▁t ension ▁device ▁to ▁predict ▁ph osph ol ip idos is ▁in ▁particular ▁c ation ic ▁dru gs . ▁ ▁Under standing ▁the ▁sol ub ility ▁of ▁dru gs ▁ ▁D rug ▁sol ub ility ▁has ▁previously ▁been ▁done ▁by ▁the ▁sh aker ▁method . ▁ ▁A ▁ 9 6 - well ▁high ▁through put ▁device ▁has ▁allowed