▁the ▁formation ▁of ▁a ort ic ▁spr out ing ▁and ▁t ube - like ▁form ations . ▁A IF 1 ▁been ▁shown ▁to ▁interact ▁with ▁kin ase ▁p 4 4 / 4 2 ▁and ▁PA K 1 , ▁two ▁previously ▁known ▁signal ▁trans du ction ▁mole cules , ▁in ▁reg ulating ▁these ▁processes . ▁A IF 1 ▁also ▁shows ▁distinct ▁differences ▁in ▁the ▁path ways ▁by ▁which ▁it ▁regul ates ▁end oth el ial ▁cells , ▁macro ph ages , ▁and ▁v asc ular ▁smooth ▁mus cle ▁cells . ▁ ▁C lin ical ▁significance ▁▁ ▁Al log raft ▁In fl am mat ory ▁F actor ▁ 1 ▁is ▁found ▁in ▁activ ated ▁macro ph ages . ▁Activ ated ▁macro ph ages ▁are ▁found ▁in ▁t issues ▁with ▁infl amm ation . ▁A IF 1 ▁levels ▁in ▁health y ▁humans ▁have ▁been ▁found ▁to ▁posit ively ▁correlate ▁with ▁met abol ic ▁indic ators , ▁such ▁as ▁body ▁mass ▁index , ▁trig ly cer ides , ▁and ▁fast ing ▁pl asma ▁gl uc ose ▁levels . ▁The ▁excess ▁of ▁ad ip ose ▁t issue ▁found ▁in ▁ob ese ▁patients ▁is ▁found ▁to ▁cause ▁chron ic ▁infl amm ation ▁with ▁an ▁increase ▁in ▁the ▁number ▁of ▁activ ated ▁macro ph ages . ▁Sub sequently , ▁A IF 1 ▁may ▁be ▁an ▁accurate ▁indicator ▁of ▁macro ph age ▁activation ▁in ▁the ▁body . ▁There ▁is ▁also ▁evidence ▁that ▁A IF 1 ▁could ▁be ▁a ▁marker ▁for ▁di ab etic ▁ne ph rop ath y ▁when ▁detected ▁in