▁their ▁essential ▁roles ▁in ▁cell - cell ▁sign alling , ▁ad hes ion , ▁and ▁EC M ▁maintenance . ▁Their ▁roles ▁in ▁blood ▁co ag ulation , ▁chron ic ▁infl amm ation , ▁and ▁cor nea ▁maintenance ▁mentioned ▁in ▁the ▁Bi ological ▁Function ▁section ▁above ▁are ▁all ▁of ▁interest ▁for ▁potential ▁th era pe ut ic ▁purposes . ▁In ▁addition ▁to ▁these ▁roles , ▁car bo h yd rate ▁sul f otr ans fer ases ▁are ▁of ▁ph arm ac ological ▁interest ▁because ▁of ▁their ▁roles ▁in ▁vir al ▁in fection , ▁including ▁her pes ▁simple x ▁virus ▁ 1 ▁( H SV - 1 ) ▁and ▁human ▁imm un ode fic iency ▁virus ▁ 1 ▁( H IV - 1 ). ▁He par an ▁sul f ate ▁sites ▁have ▁been ▁shown ▁to ▁be ▁essential ▁for ▁H SV - 1 ▁binding ▁that ▁leads ▁to ▁the ▁virus ▁entering ▁the ▁cell . ▁In ▁contrast , ▁he par an ▁sul f ate ▁complex es ▁have ▁been ▁shown ▁to ▁bind ▁to ▁H IV - 1 ▁and ▁prevent ▁it ▁from ▁entering ▁the ▁cell ▁through ▁its ▁intended ▁target , ▁the ▁CD 4 ▁re ceptor . ▁ ▁Mut ation ▁in ▁Car bo h yd rate ▁sul f otr ans fer ases ▁ 6 ▁( CH ST 6 ) ▁is ▁associated ▁with ▁Mac ular ▁Cor ne al ▁D yst ro phy ▁( M CD ) ▁In herit ance : ▁Aut os om al ▁re cess ive . ▁Gen etic ▁L ocus : ▁ 1 6 q 2 2 ▁Online ▁M end