is ▁in ▁m ice ▁and ▁sp iro cha eta ▁in fection ▁in ▁rabb its . ▁While ▁their ▁early ▁comp ounds ▁were ▁too ▁to xic , ▁Ehr lich ▁and ▁Sah ach iro ▁H ata , ▁a ▁Japanese ▁b acter i ologist ▁working ▁with ▁Er lich ▁in ▁the ▁quest ▁for ▁a ▁drug ▁to ▁treat ▁sy ph ilis , ▁achieved ▁success ▁with ▁the ▁ 6 0 6 th ▁comp ound ▁in ▁their ▁series ▁of ▁experiments . ▁In ▁ 1 9 1 0 ▁Ehr lich ▁and ▁H ata ▁announced ▁their ▁discovery , ▁which ▁they ▁called ▁drug ▁" 6 0 6 ", ▁at ▁the ▁Congress ▁for ▁In ternal ▁Medicine ▁at ▁Wies b aden . ▁The ▁Ho ech st ▁company ▁began ▁to ▁market ▁the ▁comp ound ▁toward ▁the ▁end ▁of ▁ 1 9 1 0 ▁under ▁the ▁name ▁Salv ars an , ▁now ▁known ▁as ▁ar s phen am ine . ▁The ▁drug ▁was ▁used ▁to ▁treat ▁sy ph ilis ▁in ▁the ▁first ▁half ▁of ▁the ▁ 2 0 th ▁century . ▁In ▁ 1 9 0 8 , ▁Ehr lich ▁received ▁the ▁Nobel ▁Prize ▁in ▁Phys i ology ▁or ▁Medicine ▁for ▁his ▁contributions ▁to ▁imm un ology . ▁H ata ▁was ▁nominated ▁for ▁the ▁Nobel ▁Prize ▁in ▁Chem istry ▁in ▁ 1 9 1 1 ▁and ▁for ▁the ▁Nobel ▁Prize ▁in ▁Phys i ology ▁or ▁Medicine ▁in ▁ 1 9 1 2 ▁and ▁ 1 9 1 3 . ▁ ▁The ▁first ▁sul fon am ide ▁and ▁the ▁first ▁system ically ▁active ▁ant ib acter ial ▁drug ,