, ▁especially ▁end urance ▁exercise ▁( e . g ., ▁mar athon ▁running ), ▁actually ▁prevents ▁the ▁development ▁of ▁certain ▁drug ▁add ict ions ▁and ▁is ▁an ▁effective ▁adj unct ▁treatment ▁for ▁drug ▁add iction , ▁and ▁psych ost im ul ant ▁add iction ▁in ▁particular . ▁ ▁Cons istent ▁aer ob ic ▁exercise ▁magnitude - dep end ently ▁( i . e ., ▁by ▁duration ▁and ▁intensity ) ▁reduces ▁drug ▁add iction ▁risk , ▁which ▁appears ▁to ▁occur ▁through ▁the ▁revers al ▁of ▁drug - indu ced , ▁add iction - related ▁ne uro pl astic ity . ▁One ▁review ▁noted ▁that ▁exercise ▁may ▁prevent ▁the ▁development ▁of ▁drug ▁add iction ▁by ▁alter ing ▁ Δ F os B ▁or ▁c - F os ▁imm un ore activity ▁in ▁the ▁stri atum ▁or ▁other ▁parts ▁of ▁the ▁reward ▁system . ▁Moreover , ▁aer ob ic ▁exercise ▁decre ases ▁psych ost im ul ant ▁self - admin istration , ▁reduces ▁the ▁re inst at ement ▁( i . e ., ▁re lapse ) ▁of ▁drug - se ek ing , ▁and ▁indu ces ▁opposite ▁effects ▁on ▁stri atal ▁dop am ine ▁re ceptor ▁D 2 ▁( DR D 2 ) ▁signal ing ▁( in cre ased ▁DR D 2 ▁density ) ▁to ▁those ▁induced ▁by ▁path ological ▁stim ul ant ▁use ▁( de cre ased ▁DR D 2 ▁density ). ▁Con sequently , ▁consistent ▁aer ob ic ▁exercise ▁may ▁lead ▁to ▁better ▁treatment ▁out comes ▁when ▁used ▁as ▁an ▁adj unct ▁treatment ▁for