. ▁C lin ically , ▁the ▁T EM ▁is ▁useful ▁for ▁near ▁real - time ▁measurement ▁of ▁activ ated ▁f ibr in ol ysis ▁for ▁at - ris k ▁patients , ▁such ▁as ▁those ▁experien cing ▁significant ▁blood ▁loss ▁during ▁surg ery . ▁ ▁Test ing ▁of ▁overall ▁f ibr in ol ysis ▁can ▁be ▁measured ▁by ▁a ▁e ug lob ul in ▁l ysis ▁time ▁( E LT ) ▁ass ay . ▁The ▁E LT ▁measures ▁f ibr in ol ysis ▁by ▁cl ot ting ▁the ▁e ug lob ul in ▁fraction ▁( prim arily ▁the ▁important ▁f ibr in ol yt ic ▁factors ▁f ibr in ogen , ▁PA I - 1 , ▁t PA , ▁alpha ▁ 2 - anti pl as min , ▁and ▁pl as min ogen ) ▁from ▁pl asma ▁and ▁then ▁obser ving ▁the ▁time ▁required ▁for ▁cl ot ▁dissol ution . ▁A ▁short ened ▁l ysis ▁time ▁indicates ▁a ▁hyper f ibr in ol yt ic ▁state ▁and ▁ble eding ▁risk . ▁Such ▁results ▁can ▁be ▁seen ▁in ▁pe op les ▁with ▁li ver ▁disease , ▁PA I - 1 ▁def ic iency ▁or ▁alpha ▁ 2 - anti pl as min ▁def ic iency . ▁Similar ▁results ▁are ▁also ▁seen ▁after ▁administration ▁of ▁D D AV P ▁or ▁after ▁severe ▁stress . ▁ ▁Ro le ▁in ▁disease ▁F ew ▁con gen ital ▁dis orders ▁of ▁the ▁f ibr in ol yt ic ▁system ▁have ▁been ▁documented . ▁Nevertheless , ▁excess ▁levels ▁of ▁PA I