▁in va de ▁due ▁to ▁the ▁loss ▁of ▁their ▁ability ▁to ▁dis rupt ▁the ▁ext rac ell ular ▁matrix . <0x09> ▁ <0x09> ▁Single ▁cell ▁invasion ▁or ▁individual ▁cell ▁migration <0x09> ▁ <0x09> ▁Such ▁a ▁type ▁of ▁invas ive ▁growth ▁as ▁single ▁cell ▁invasion ▁is ▁distinguished ▁based ▁on ▁the ▁detection , ▁during ▁morph ological ▁analysis , ▁of ▁individual ▁tum or ▁cells ▁that ▁in va de ▁the ▁surrounding ▁t issues ▁independently ▁of ▁each ▁other . ▁In ▁this ▁type ▁of ▁tum or ▁invasion , ▁single ▁cell ▁migration ▁can ▁occur ▁via ▁two ▁different ▁movement ▁types : ▁mes en ch ym al ▁and ▁am o eb oid . ▁A ▁number ▁of ▁research ers ▁point ▁to ▁the ▁possibility ▁of ▁a ▁“ shift ” ▁from ▁one ▁type ▁of ▁migration ▁to ▁the ▁other ▁( from ▁mes en ch ym al ▁to ▁am o eb oid ▁and ▁vice ▁vers a , ▁Fig . ▁ 1 ) ▁in ▁the ▁case ▁of ▁single ▁cell ▁invasion . ▁These ▁trans itions ▁usually ▁occur ▁upon ▁changes ▁in ▁the ▁activity ▁of ▁certain ▁cell ▁mole cules ▁when ▁tum or ▁cells ▁have ▁to ▁adapt ▁to ▁the ▁peculiar ities ▁of ▁the ▁micro environment . <0x09> ▁ <0x09> ▁M esen ch ym al ▁( f ib ro blast - like ) ▁cell ▁migration <0x09> ▁ <0x09> ▁The ▁mes en ch ym al ▁mechan isms ▁of ▁invas ive ▁cell ▁growth , ▁in ▁contrast ▁to ▁the ▁am o eb oid ▁type ▁of ▁migration , ▁are ▁character ized ▁by ▁the ▁occurrence ▁of ▁more ▁complex ▁processes ▁and ▁a ▁need ▁for ▁the ▁invol vement ▁of ▁a