▁path way ▁by ▁reg ulating ▁shed ding ▁of ▁the ▁E G FR ▁lig and ▁am ph ire g ul in ▁in ▁the ▁m amm ary ▁g land . ▁AD AM 1 7 ▁also ▁has ▁a ▁role ▁in ▁the ▁shed ding ▁of ▁L - select in , ▁a ▁cell ular ▁ad hes ion ▁mole c ule . ▁ ▁Inter actions ▁▁ ▁AD AM 1 7 ▁has ▁been ▁shown ▁to ▁interact ▁with : ▁ ▁D L G 1 ▁▁ ▁M AD 2 L 1 , ▁and ▁ ▁M AP K 1 . ▁ ▁Cell ular ▁local ization ▁▁ ▁The ▁local ization ▁of ▁AD AM 1 7 ▁is ▁spec ulated ▁to ▁be ▁an ▁important ▁determin ant ▁of ▁shed ding ▁activity . ▁T NF - α ▁processing ▁has ▁class ically ▁been ▁understood ▁to ▁occur ▁in ▁the ▁trans - G ol gi ▁network , ▁and ▁be ▁closely ▁connected ▁to ▁transport ▁of ▁sol ub le ▁T NF - α ▁to ▁the ▁cell ▁surface . ▁However , ▁research ▁that ▁suggests ▁that ▁the ▁majority ▁of ▁m ature , ▁end ogen ous ▁AD AM 1 7 ▁may ▁be ▁local ized ▁to ▁a ▁per in uc lear ▁compart ment , ▁with ▁only ▁a ▁small ▁amount ▁of ▁T ACE ▁being ▁present ▁on ▁the ▁cell ▁surface . ▁The ▁local ization ▁of ▁m ature ▁AD AM 1 7 ▁to ▁a ▁per in uc lear ▁compart ment , ▁therefore , ▁ra ises ▁the ▁possibility ▁that ▁AD AM 1 7 - medi ated ▁e ct od om ain ▁shed ding ▁may ▁also ▁occur ▁in ▁the ▁int rac ell