pat ot ox icity ▁in ▁comparison . ▁ ▁As ide ▁from ▁its ▁risk ▁of ▁li ver ▁to x icity ▁and ▁besides ▁other ▁non st ero idal ▁anti and rog ens , ▁it ▁has ▁been ▁said ▁that ▁fl ut am ide ▁is ▁likely ▁the ▁best ▁typically ▁used ▁anti andro gen ▁medic ation ▁for ▁the ▁treatment ▁of ▁and ro gen - dependent ▁sympt oms ▁in ▁women . ▁This ▁is ▁related ▁to ▁its ▁high ▁effect iveness ▁and ▁minimal ▁side ▁effects . ▁ ▁Ac ne ▁and ▁se bor r he a ▁Fl ut am ide ▁has ▁been ▁found ▁to ▁be ▁effective ▁in ▁the ▁treatment ▁of ▁ac ne ▁and ▁se bor r he a ▁in ▁women ▁in ▁a ▁number ▁of ▁studies . ▁In ▁a ▁long - term ▁study ▁of ▁ 2 3 0   w omen ▁with ▁ac ne , ▁ 2 1 1 ▁of ▁whom ▁also ▁had ▁se bor r he a , ▁very - low - d ose ▁fl ut am ide ▁alone ▁or ▁in ▁combination ▁with ▁an ▁or al ▁contra cept ive ▁caused ▁a ▁marked ▁decrease ▁in ▁ac ne ▁and ▁se bor r he a ▁after ▁ 6   month s ▁of ▁treatment , ▁with ▁maximal ▁effect ▁by ▁ 1   year ▁of ▁treatment ▁and ▁benefits ▁maintained ▁in ▁the ▁years ▁there after . ▁In ▁the ▁study , ▁ 9 7 % ▁of ▁the ▁women ▁reported ▁satisfaction ▁with ▁the ▁control ▁of ▁their ▁ac ne ▁with ▁fl ut am ide . ▁In ▁another ▁study , ▁fl ut am ide ▁decre ased ▁ac ne ▁and ▁se bor r