, ▁meaning ▁that ▁due ▁to ▁interrupted ▁o xygen ▁supply ▁to ▁the ▁s ple en ▁partial ▁or ▁complete ▁t issue ▁death ▁happens . ▁On ▁the ▁cell ular ▁level , ▁the ▁s ple en ▁contains ▁red ▁blood ▁cell ▁prec urs ors , ▁gran ul ocy te ▁prec urs ors ▁and ▁meg ak ary ocy tes , ▁with ▁the ▁meg ak ary ocy tes ▁prominent ▁in ▁their ▁number ▁and ▁in ▁their ▁b izar re ▁shapes . ▁Meg ak ary ocy tes ▁are ▁believed ▁to ▁be ▁involved ▁in ▁causing ▁the ▁secondary ▁fib ros is ▁seen ▁in ▁this ▁condition , ▁as ▁discussed ▁under ▁" Me chan ism " ▁above . ▁Sometimes ▁unusual ▁activity ▁of ▁the ▁red ▁blood ▁cells , ▁white ▁blood ▁cells , ▁or ▁plate lets ▁is ▁seen . ▁ ▁The ▁li ver ▁is ▁often ▁moder ately ▁en larg ed , ▁with ▁fo ci ▁of ▁extr amed ull ary ▁h emat opo ies is . ▁Micro scop ically , ▁l ym ph ▁nodes ▁also ▁contain ▁fo ci ▁of ▁h emat opo ies is , ▁but ▁these ▁are ▁ins u fficient ▁to ▁cause ▁en larg ement . ▁ ▁There ▁are ▁also ▁reports ▁of ▁h emat opo ies is ▁taking ▁place ▁in ▁the ▁l ungs . ▁These ▁cases ▁are ▁associated ▁with ▁hy pert ension ▁in ▁the ▁pul mon ary ▁ar ter ies . ▁ ▁The ▁b one ▁mar row ▁in ▁a ▁typical ▁case ▁is ▁hyper cell ular ▁and ▁diffus ely ▁fib rot ic . ▁Both ▁early ▁and ▁late ▁in ▁disease , ▁meg ak ary ocy tes ▁are ▁often ▁prominent ▁and