6 0 ▁times ▁more ▁active ▁as ▁an ▁ant ich ol iner g ic ▁than ▁as ▁a ▁dop am iner g ic . ▁ ▁M 1 ▁re ceptor ▁consider ations ▁aside , ▁analog ues ▁of ▁this ▁ben zt rop ine ▁class ▁still ▁won ' t ▁substitute ▁for ▁c oca ine , ▁and ▁have ▁no ▁prop ens ity ▁to ▁elev ate ▁locomot or ▁activity . ▁▁ ɑ In hib ition ▁at ▁ 1 0 ▁ μ M ▁ ▁Trop any l ▁I so x az oline ▁Anal og ues ▁▁ 8 - A min op ent acy clo ▁( σ ▁re ceptor ▁lig and ) ▁Tr ish om oc ub ane ▁Anal ogs ▁c f . ▁other ▁tr ish om oc ub anes ▁such ▁as ▁basket ane . ▁ ▁S igma ▁re ceptor ▁ag on ists ▁with ▁nan om olar ▁aff inity ▁such ▁as ▁C M 1 5 6 ▁have ▁been ▁shown ▁to ▁counter act ▁the ▁de le ter ious ▁effects ▁of ▁c oca ine ▁when ▁co - admin ister ed ▁with ▁it . ▁Ind ic ative ▁that ▁e . g . ▁the ▁local ▁an est h etic ▁effect ▁at ▁the ▁s igma ▁site ▁medi ating ▁the ▁to x icity ▁or ▁otherwise ▁a ▁cross ▁over ▁or ▁tie ▁in ▁of ▁c oca ine ' s ▁separate ▁functional ities ▁lower ing ▁threshold ▁to ▁its ▁safety ▁profile . ▁Poly cyc lic ▁c age ▁mole cules : ▁N - subst it uted ▁ 8 - amin op ent acy clo [ 5 . 4 . 0 . 0 2