▁take ▁fl ut am ide ▁multiple ▁times ▁per ▁day . ▁ ▁Fl ut am ide ▁was ▁first ▁described ▁in ▁ 1 9 6 7 ▁and ▁was ▁first ▁introduced ▁for ▁medical ▁use ▁in ▁ 1 9 8 3 . ▁It ▁became ▁available ▁in ▁the ▁United ▁States ▁in ▁ 1 9 8 9 . ▁The ▁medic ation ▁has ▁largely ▁been ▁replaced ▁by ▁newer ▁and ▁improved ▁NS A As , ▁namely ▁b ical ut am ide ▁and ▁en z al ut am ide , ▁due ▁to ▁their ▁better ▁effic acy , ▁toler ability , ▁safety , ▁and ▁dos ing ▁frequency ▁( once ▁per ▁day ), ▁and ▁is ▁now ▁relatively ▁little - used . ▁ ▁Medical ▁uses ▁ ▁Pro state ▁cancer ▁G n R H ▁is ▁released ▁by ▁the ▁hypoth al am us ▁in ▁a ▁p uls atile ▁fashion ; ▁this ▁causes ▁the ▁anterior ▁p itu it ary ▁g land ▁to ▁release ▁l ute in izing ▁h orm one ▁( L H ) ▁and ▁fol lic le - st im ulating ▁h orm one ▁( F SH ). ▁L H ▁stim ul ates ▁the ▁test es ▁to ▁produce ▁test oster one , ▁which ▁is ▁met abol ized ▁to ▁D HT ▁by ▁the ▁en zym e ▁ 5 α - re duct ase . ▁ ▁D HT , ▁and ▁to ▁a ▁significantly ▁smaller ▁extent , ▁test oster one , ▁stim ulate ▁pro state ▁cancer ▁cells ▁to ▁grow . ▁Therefore , ▁blocking ▁these ▁and rog ens ▁can ▁provide ▁powerful ▁treatment ▁for ▁pro state ▁cancer , ▁especially ▁met ast atic