▁re ceptor ▁( R X R ) ▁resulting ▁in ▁activation ▁or ▁repr ession ▁of ▁target ▁gene ▁trans cription . ▁C AR - reg ulated ▁gen es ▁are ▁involved ▁in ▁drug ▁met abol ism ▁and ▁bil ir ub in ▁ ▁clear ance . ▁Ex amples ▁for ▁C AR - reg ulated ▁gen es ▁are ▁members ▁of ▁the ▁C Y P 2 B , ▁C Y P 2 C , ▁and ▁C Y P 3 A ▁sub famil ies , ▁sul f otr ans fer ases , ▁and ▁gl ut ath ione - S - trans fer ases . ▁Lig ands ▁binding ▁to ▁C AR ▁include ▁bil ir ub in , ▁a ▁variety ▁of ▁foreign ▁comp ounds , ▁ster oid ▁h orm ones , ▁and ▁pres cription ▁dru gs . ▁ ▁Activ ation ▁mechanism ▁▁ ▁Ph osph ory l ated ▁C AR ▁forms ▁a ▁multip rote in ▁complex ▁with ▁the ▁heat ▁shock ▁protein ▁ 9 0 ▁( h sp 9 0 ) ▁and ▁the ▁cy top las mic ▁C AR ▁ret ention ▁protein ▁( CC R P ) ▁which ▁keep ▁C AR ▁in ▁the ▁c yt os ol ▁thereby ▁in activ ating ▁it . ▁C AR ▁can ▁be ▁activ ated ▁in ▁two ▁ways : ▁by ▁direct ▁binding ▁of ▁a ▁lig and ▁( e . g . ▁TCP OB OP ) ▁or ▁indirect ▁reg ulation ▁by ▁phen obar b ital ▁( P B ), ▁a ▁common ▁se iz ure ▁medic ation , ▁facil it ating ▁the ▁de ph osph ory lation ▁of ▁C AR ▁through ▁protein