ant ▁medic ation ▁aug ments ▁the ▁effect ▁of ▁stim ul ant ▁medic ation ▁on ▁executive ▁function . ▁ ▁It ▁is ▁believed ▁that ▁these ▁short - term ▁effects ▁of ▁exercise ▁are ▁medi ated ▁by ▁an ▁increased ▁abund ance ▁of ▁syn apt ic ▁dop am ine ▁and ▁n ore pine phr ine ▁in ▁the ▁brain . ▁ ▁Major ▁de press ive ▁dis order ▁A ▁number ▁of ▁medical ▁reviews ▁have ▁indicated ▁that ▁exercise ▁has ▁a ▁marked ▁and ▁persistent ▁ant ide press ant ▁effect ▁in ▁humans , ▁an ▁effect ▁believed ▁to ▁be ▁medi ated ▁through ▁en hanced ▁ ▁signal ing ▁in ▁the ▁brain . ▁Several ▁system atic ▁reviews ▁have ▁analyz ed ▁the ▁potential ▁for ▁physical ▁exercise ▁in ▁the ▁treatment ▁of ▁de press ive ▁dis orders . ▁The ▁ 2 0 1 3 ▁C och rane ▁Coll abor ation ▁review ▁on ▁ ▁for ▁de pression ▁noted ▁that , ▁based ▁upon ▁limited ▁evidence , ▁it ▁is ▁more ▁effective ▁than ▁a ▁control ▁inter vention ▁and ▁compar able ▁to ▁psych ological ▁or ▁ant ide press ant ▁drug ▁ther ap ies . ▁Three ▁subsequent ▁ 2 0 1 4 ▁system atic ▁reviews ▁that ▁included ▁the ▁C och rane ▁review ▁in ▁their ▁analysis ▁concluded ▁with ▁similar ▁find ings : ▁one ▁indicated ▁that ▁physical ▁exercise ▁is ▁effective ▁as ▁an ▁adj unct ▁treatment ▁( i . e ., ▁treat ments ▁that ▁are ▁used ▁together ) ▁with ▁ant ide press ant ▁medic ation ; ▁the ▁other ▁two ▁indicated ▁that ▁physical ▁exercise ▁has ▁marked ▁ant ide press ant ▁effects ▁and ▁recommended ▁the ▁inclusion ▁of ▁physical ▁activity ▁as