MC 1 ß , ▁ ▁RE C 8 ▁and ▁S TAG 3 ▁prote ins ▁are ▁me ios is ▁specific ▁coh es ins . ▁ ▁The ▁S TAG 3 ▁protein ▁appears ▁to ▁be ▁essential ▁for ▁female ▁me ios is . ▁ ▁A ▁hom o zy g ous ▁frames h ift ▁mut ation ▁in ▁the ▁St ag 3 ▁gene ▁was ▁identified ▁in ▁a ▁large ▁cons angu ine ous ▁family ▁with ▁prem ature ▁o var ian ▁failure . ▁ ▁Also , ▁female ▁m ice ▁def ic ient ▁in ▁S TAG 3 ▁are ▁ster ile , ▁and ▁their ▁f etal ▁o ocy tes ▁arrest ▁at ▁early ▁pro phase ▁ 1 . ▁ ▁E volution ▁ ▁C oh es in ▁structure ▁and ▁function ▁has ▁been ▁conser ved ▁in ▁evolution . ▁The ▁S MC ▁prote ins ▁are ▁found ▁in ▁pro k ary otes ▁and ▁have ▁been ▁conser ved ▁through ▁evolution . ▁The ▁co ils ▁of ▁S MC 1 ▁and ▁S MC 3 ▁are ▁conser ved ▁with ▁an ▁am ino ▁acid ▁diver gence ▁of ▁less ▁than ▁ 0 . 5 %. ▁ ▁C lin ical ▁significance ▁ ▁The ▁term ▁" co hes in op ath y " ▁has ▁been ▁used ▁to ▁describe ▁conditions ▁affect ing ▁the ▁coh es in ▁complex . ▁ ▁These ▁conditions ▁include : ▁ ▁Corn elia ▁de ▁L ange ▁Sy nd rome ▁ ▁Roberts ▁synd rome ▁ ▁Wars aw ▁break age ▁synd rome ▁ ▁Many ▁types ▁of ▁m align an cies ▁ ▁See ▁also ▁▁ ▁Cond ens in ▁ ▁S MC ▁protein ▁ ▁Est ab lish ment