ular ▁environment , ▁in ▁contrast ▁with ▁the ▁conventional ▁model . ▁ ▁Function al ▁AD AM 1 7 ▁has ▁been ▁documented ▁to ▁be ▁u bi quit ously ▁expressed ▁in ▁the ▁human ▁colon , ▁with ▁increased ▁activity ▁in ▁the ▁colon ic ▁m uc osa ▁of ▁patients ▁with ▁ul cer ative ▁col itis , ▁a ▁main ▁form ▁of ▁infl am mat ory ▁bow el ▁disease . ▁Other ▁experiments ▁have ▁also ▁suggested ▁that ▁expression ▁of ▁AD AM 1 7 ▁may ▁be ▁in hib ited ▁by ▁eth an ol . ▁ ▁Model ▁organ isms ▁▁▁ <0x09> <0x09> <0x09> <0x09> ▁Model ▁organ isms ▁have ▁been ▁used ▁in ▁the ▁study ▁of ▁AD AM 1 7 ▁function . ▁A ▁conditional ▁knock out ▁mouse ▁line , ▁called ▁Adam 1 7 tm 1 a ( E U CO MM ) W t si ▁was ▁generated ▁as ▁part ▁of ▁the ▁International ▁Kno ck out ▁Mouse ▁Cons ort ium ▁program ▁— ▁a ▁high - through put ▁mut agen esis ▁project ▁to ▁generate ▁and ▁dist ribute ▁animal ▁models ▁of ▁disease ▁to ▁interested ▁scient ists . ▁ ▁Male ▁and ▁female ▁animals ▁under w ent ▁a ▁standard ized ▁phen ot yp ic ▁screen ▁to ▁determine ▁the ▁effects ▁of ▁delet ion . ▁Tw enty ▁eight ▁tests ▁were ▁carried ▁out ▁on ▁mut ant ▁m ice ▁and ▁two ▁significant ▁ab normal ities ▁were ▁observed . ▁F ew ▁hom o zy g ous ▁mut ant ▁emb ry os ▁were ▁identified ▁during ▁gest ation . ▁The ▁remaining ▁tests ▁were ▁carried ▁out ▁on ▁heter o zy g ous ▁mut ant ▁adult ▁m ice ;