6 8 ▁years ▁old . ▁Of ▁these ▁people ▁with ▁di ab etes ▁carrying ▁the ▁mit och ond rial ▁DNA ▁mut ation ▁at ▁position ▁ 3 2 4 3 , ▁ 7 5 % ▁experience ▁sensor ine ural ▁hearing ▁loss . ▁In ▁these ▁cases , ▁hearing ▁loss ▁normally ▁appears ▁before ▁the ▁on set ▁of ▁di ab etes ▁and ▁is ▁marked ▁by ▁a ▁decrease ▁in ▁per ception ▁of ▁high ▁tone ▁frequencies . ▁The ▁associated ▁hearing ▁loss ▁with ▁di ab etes ▁is ▁typically ▁more ▁common ▁and ▁more ▁quickly ▁decl ining ▁in ▁men ▁than ▁in ▁women . ▁ ▁Effect ▁of ▁mut ation ▁on ▁t R N AL eu ( U UR ) ▁ ▁M ito ch ond ria ▁have ▁their ▁own ▁circular ▁gen ome ▁which ▁contains ▁ 3 7 ▁gen es , ▁of ▁which ▁ 2 2 ▁code ▁for ▁t R N As . ▁These ▁t R N As ▁play ▁an ▁essential ▁role ▁in ▁protein ▁synth esis ▁by ▁transport ing ▁am ino ▁ac ids ▁to ▁the ▁rib os ome . ▁ ▁M ID D ▁is ▁caused ▁by ▁an ▁A ▁to ▁G ▁substitution ▁in ▁the ▁mit och ond rial ▁DNA ▁at ▁position ▁ 3 2 4 3 , ▁which ▁enc odes ▁t R N AL eu ( U UR ). ▁This ▁mut ation ▁is ▁typically ▁in ▁heter op las mic ▁form . ▁A ▁mut ation ▁in ▁this ▁gene ▁( A 3 2 4 3 G ) ▁causes ▁the ▁native ▁con formation ▁to ▁be ▁dest abil ized , ▁as ▁well ▁as ▁dim er ization ▁in ▁the ▁t R N