0 0 ▁animals ▁treated ▁and ▁were ▁generally ▁self - lim iting ▁and ▁of ▁short ▁duration , ▁ ▁In ▁vit ro ▁studies ▁reported ▁that ▁a fox olan er ▁can ▁bind ▁to ▁dop am ine ▁and ▁n ore pine phr ine ▁cell ular ▁transport ▁re ceptor ▁systems ▁and ▁the ▁C B 1 ▁re ceptor ; ▁in hib ition ▁of ▁these ▁c ate ch ol am iner g ic ▁systems ▁and ▁certain ▁types ▁of ▁compet itive ▁binding ▁at ▁C B 1 ▁re cept ors ▁may ▁medi ate ▁ph arm ac od ynamic ▁effects ▁of ▁di ures is , ▁decre ased ▁food ▁consumption , ▁and ▁decre ased ▁body ▁weight ▁in ▁animals . ▁ ▁According ▁to ▁post - mark eting ▁safety ▁experience : ▁▁ ▁( in ▁combination ▁with ▁mil b emy cin ▁ox ime ): ▁er yth ema ▁and ▁ne uro log ical ▁signs ▁( conv uls ions , ▁at ax ia ▁and ▁mus cle ▁trem ors ) ▁have ▁been ▁reported ▁in ▁less ▁than ▁ 0 . 1 % ▁of ▁ 1 0 , 0 0 0 ▁animals ▁treated , ▁including ▁isolated ▁reports , ▁ ▁The ▁US ▁F DA ▁reports ▁that ▁some ▁dru gs ▁in ▁this ▁class ▁( is ox az ol ines ), ▁including ▁a fox al an er , ▁can ▁have ▁ad verse ▁ne uro logic ▁effects ▁on ▁some ▁dogs , ▁such ▁as ▁mus cle ▁trem ors , ▁at ax ia , ▁and ▁se iz ures . ▁ ▁Select ivity ▁insect s ▁over ▁m amm ali ans ▁ ▁In ▁v ivo ▁studies ▁( repeat - d