▁human ▁add iction ▁models ▁has ▁to ▁do ▁with ▁the ▁respective ▁difference ▁in ▁their ▁entropy ▁of ▁binding : ▁c oca ine ▁being ▁— 5 . 6 ▁k cal / m ol ▁& ▁m eth yl phen id ate ▁being ▁— 2 5 . 5 ▁k cal / m ol ▁( Δ s ° , ▁measured ▁using ▁[ ³ H ] GB R ▁ 1 2 7 8 ▁@ ▁ 2 5   ° C ) ▁ ▁J Z - IV - 1 0 ▁( a ▁" Mod af in il ▁hy brid " ▁with ▁n oca ine . ▁c f . ▁List ▁of ▁mod af in il ▁analog ues ) ▁▁ ▁N oca ine ▁ ▁A ▁somewhat ▁recent ▁occurrence ▁among ▁tent ative ▁modern ▁fol kl ore ▁which ▁has ▁travers ed ▁the ▁cir cling ▁of ▁rum ors ▁mostly ▁conf ined ▁to ▁the ▁lik es ▁of ▁univers ities ▁and ▁popular ▁culture ▁t riv ia ▁has ▁been ▁that ▁c oca ine ▁is ▁one ▁element , ▁or ▁mole c ule ▁increment ▁of ▁weight ▁or ▁charge ▁etc ., ▁away ▁from ▁the ▁mole cular ▁structure ▁of ▁sugar . ▁Though ▁such ▁a ▁statement ▁is ▁false ▁as ▁a ▁general ▁pre ten se , ▁there ▁is ▁a ▁de xt rose ▁based ▁super - structure ▁that ▁has ▁a ▁v agu ely ▁similar ▁overlay ▁with ▁c oca ine ▁which ▁is ▁" ben zo yl - beta - D - gl uc os ide ." ▁Ben zo yl - beta - D - gl uc os ide ▁ ▁Ben zt rop ine ▁( 3 α -