X 1 ), ▁ring ▁finger ▁protein ▁ 2 4 ▁( R NF 2 4 ), ▁and ▁SE C 1 4 ▁domain ▁and ▁spect rin ▁repeat - cont aining ▁protein ▁ 1 ▁( SE ST D 1 ). ▁ ▁TR PC 4 ▁and ▁TR PC 5 ▁have ▁been ▁imp licated ▁in ▁the ▁mechanism ▁of ▁mer cur y ▁to x icity ▁and ▁ne uro log ical ▁behavior . ▁ ▁Activ ation ▁▁ ▁Hom om ult imer ic ▁TR PC 5 ▁and ▁heter om ult imer ic ▁TR PC 5 - TR PC 1 ▁channels ▁are ▁activ ated ▁by ▁ext rac ell ular ▁reduced ▁th ior ed ox in . ▁This ▁channel ▁has ▁also ▁been ▁found ▁to ▁be ▁involved ▁in ▁the ▁action ▁of ▁an a est het ics ▁such ▁as ▁ch lor o form , ▁hal oth ane ▁and ▁prop of ol . ▁ ▁Inter actions ▁▁ ▁TR PC 5 ▁has ▁been ▁shown ▁to ▁interact ▁with ▁ST M N 3 , ▁TR PC 1 , ▁and ▁TR PC 4 . ▁ ▁See ▁also ▁▁ ▁TR PC ▁ ▁References ▁ ▁Further ▁reading ▁ ▁External ▁links ▁▁▁▁ ▁Category : I on ▁channels <0x0A> </s> ▁My ▁F av our ite ▁Film ▁was ▁a ▁television ▁special ▁broadcast ▁on ▁the ▁ABC ▁on ▁ 4 ▁December ▁ 2 0 0 5 . ▁After ▁public ▁voting ▁took ▁place ▁on ▁the ▁show ' s ▁website , ▁the ▁special ▁listed ▁the ▁top ▁ten ▁most ▁popular ▁films ▁as ▁chosen ▁by ▁vot ers , ▁and ▁these ▁films ▁were ▁discussed ▁and ▁their ▁rank ings ▁deb ated ▁by ▁a