▁and ▁the ▁successor ▁of ▁the ▁Hel vet ia ▁vere in , ▁hold ▁ 7 9 ▁percent ▁of ▁the ▁shares , ▁whilst ▁Art is ana ' s ▁vere in ▁holds ▁ 2 1 ▁percent . ▁ ▁References ▁ ▁External ▁links ▁▁▁ ▁Website ▁Hels ana ▁AG ▁ ▁Category : Fin an cial ▁services ▁companies ▁established ▁in ▁ 1 9 9 6 ▁Category : Life ▁ins urance ▁companies ▁of ▁Switzerland ▁Category : In sur ance ▁companies ▁of ▁Switzerland ▁Category : Sw iss ▁br ands <0x0A> </s> ▁AD AM ▁metal lo pe pt id ase ▁domain ▁ 1 7 ▁( AD AM 1 7 ), ▁also ▁called ▁T ACE ▁( t um or ▁ne c ros is ▁factor - α - con ver ting ▁en zym e ), ▁is ▁a ▁ 7 0 - k Da ▁en zym e ▁that ▁belongs ▁to ▁the ▁AD AM ▁protein ▁family ▁of ▁dis integr ins ▁and ▁metal lo prote ases . ▁ ▁Chem ical ▁characteristics ▁▁ ▁AD AM 1 7 ▁is ▁an ▁ 8 2 4 - am ino ▁acid ▁pol ype pt ide . ▁ ▁Function ▁▁ ▁AD AM 1 7 ▁is ▁understood ▁to ▁be ▁involved ▁in ▁the ▁processing ▁of ▁tum or ▁ne c ros is ▁factor ▁alpha ▁( T NF - α ) ▁at ▁the ▁surface ▁of ▁the ▁cell , ▁and ▁from ▁within ▁the ▁int rac ell ular ▁memb ran es ▁of ▁the ▁trans - G ol gi ▁network . ▁This ▁process , ▁which ▁is ▁also ▁known ▁as ▁' sh ed ding ', ▁involves ▁the ▁cle av age ▁and