ed ▁c aten anes ▁without ▁acting ▁on ▁right - hand ed ▁p lect on emes ▁in ▁neg atively ▁super co iled ▁DNA ▁mole cules , ▁based ▁on ▁geomet rical ▁specific ity ▁of ▁ju xt ap os itions . ▁ ▁C lin ical ▁significance ▁Top ois omer ase ▁IV ▁is ▁also ▁a ▁target ▁of ▁ant ib iot ics , ▁such ▁as ▁the ▁qu in ol one ▁dru gs , ▁which ▁include ▁c ip ro f lo x ac in . ▁ ▁References ▁ ▁External ▁links ▁▁▁▁ ▁Category : EC ▁ 5 . 9 9 . 1 <0x0A> </s> ▁N PS ▁may ▁refer ▁to : ▁ ▁Organ izations ▁▁ ▁National ▁Park ▁Service , ▁U . S . ▁ ▁National ▁P ension ▁System , ▁India ▁ ▁National ▁P ension ▁Service , ▁Korea ▁ ▁National ▁Ph ob ics ▁Society , ▁UK ▁ ▁char ity ▁ ▁National ▁Po etry ▁S lam , ▁competition ▁▁ ▁National ▁Pro b ation ▁Service , ▁a ▁stat ut ory ▁criminal ▁justice ▁service ▁for ▁England ▁and ▁Wales ▁ ▁Nederlandse ▁Program ma ▁St icht ing , ▁a ▁Dutch ▁broadcast ing ▁foundation ▁now ▁part ▁of ▁Om ro ep ▁N TR ▁ ▁Niger ian ▁Pr isons ▁Services ▁ ▁N PS ▁Medicine W ise , ▁known ▁prior ▁to ▁ 2 0 0 9 ▁as ▁the ▁National ▁Pres cri bing ▁Service , ▁a ▁medical ▁information ▁provider ▁in ▁Australia ▁ ▁Science , ▁medicine ▁and ▁ph arma ce ut ics ▁▁ ▁N ail – pat ella ▁synd rome , ▁an ▁aut os om al ▁dominant ▁gen etic ▁dis order ▁ ▁Ne