op leg ia ▁makes ▁the ▁diagn osis ▁of ▁AD CA ▁I , ▁the ▁presence ▁of ▁ret in op ath y ▁points ▁to ▁AD CA ▁II , ▁and ▁the ▁absence ▁of ▁associated ▁signs ▁to ▁AD CA ▁III . ▁Gen etic ▁link age ▁and ▁mole cular ▁anal ys es ▁revealed ▁that ▁AD C As ▁are ▁gen et ically ▁heter ogeneous ▁even ▁within ▁the ▁various ▁sub types . ▁ ▁De fect s ▁in ▁AT X N 1 0 ▁have ▁been ▁associated ▁with ▁J ou bert ▁synd rome . ▁ ▁References ▁ ▁Further ▁reading ▁ ▁External ▁links ▁▁ ▁Gene Re views / NC BI / NI H / U W ▁entry ▁on ▁Sp in oc ere bell ar ▁A tax ia ▁Type ▁ 1 0 <0x0A> </s> ▁Sal ca j á ▁is ▁a ▁town ▁and ▁municipality ▁in ▁ ▁Qu etz al ten ango ▁department ▁of ▁Gu atem ala . ▁ ▁Sal ca j á ▁is ▁best ▁known ▁for ▁the ▁Church ▁of ▁San ▁Jac into , ▁founded ▁in ▁ 1 5 2 4 , ▁which ▁was ▁the ▁first ▁church ▁built ▁in ▁Central ▁America ▁since ▁it ▁was ▁one ▁of ▁the ▁first ▁places ▁inv aded ▁in ▁the ▁Spanish ▁con quest ▁of ▁Gu atem ala . ▁It ▁is ▁also ▁known ▁as ▁La ▁Con qu ist adora ▁(" The ▁Con quer or ") ▁pres umably ▁because ▁of ▁the ▁time ▁period ▁and ▁its ▁religious ▁influence ▁on ▁the ▁ind igen ous ▁population . ▁After ▁ 4 9 0 ▁years ▁and ▁several ▁ ▁earth qu akes , ▁the ▁building ▁still ▁is ▁in ▁relatively ▁good ▁condition