▁ben ign ▁( aden omas ) ▁and ▁only ▁occasionally ▁cause ▁C ushing ' s ▁synd rome . ▁ ▁Five - year ▁disease - free ▁surv ival ▁for ▁a ▁complete ▁res ection ▁of ▁a ▁stage ▁I – III ▁A CC ▁is ▁about ▁ 3 0 %. ▁The ▁most ▁important ▁pro gn ost ic ▁factors ▁are ▁age ▁of ▁the ▁patient ▁and ▁stage ▁of ▁the ▁tum or . ▁Po or ▁pro gn ost ic ▁factors ▁include ▁mit otic ▁activity , ▁ven ous ▁invasion , ▁weight ▁of ▁ 5 0 ▁g ▁or ▁more , ▁diameter ▁of ▁ 6 . 5   cm ▁or ▁more , ▁Ki - 6 7 / M IB 1 ▁label ing ▁index ▁of ▁ 4 % ▁or ▁more , ▁and ▁p 5 3 ▁positive . ▁ ▁References ▁ ▁External ▁links ▁▁ ▁Category : R are ▁can cers ▁Category : End ocr ine ▁ne op las ia ▁Category : End ocr ine - related ▁cut aneous ▁conditions ▁Category : Ad ren al ▁g land ▁dis orders <0x0A> </s> ▁Daniel ▁B lain , ▁M . D . ▁( 1 8 9 8 – 1 9 8 1 ) ▁was ▁an ▁American ▁phys ician ▁and ▁was ▁the ▁first ▁medical ▁director ▁of ▁the ▁American ▁Psych iat ric ▁Association ▁( AP A ), ▁the ▁first ▁professional ▁medical ▁society , ▁founded ▁in ▁the ▁United ▁States ▁in ▁ 1 8 4 4 . ▁ ▁He ▁may ▁be ▁cred ited ▁with ▁the ▁leadership ▁which ▁brought ▁changes ▁in ▁the ▁practice ▁of ▁psych iat ry ▁after ▁World ▁War ▁II ▁and ▁in ▁advoc ating