is ▁develop ▁a ▁form ▁of ▁li ver ▁cancer ▁known ▁as ▁he pat oc ell ular ▁car cin oma . Acc ording ▁to ▁T il g , ▁et ▁al ., ▁gut ▁micro bi ome ▁could ▁very ▁well ▁have ▁an ▁effect , ▁be ▁involved ▁in ▁the ▁path oph ys i ology , ▁on ▁the ▁various ▁types ▁of ▁li ver ▁disease ▁which ▁an ▁individual ▁may ▁encounter . ▁ ▁Air ▁poll ut ants ▁Part ic ulate ▁matter ▁( PM ) ▁or ▁carbon ▁black ▁( CB ) ▁are ▁common ▁poll ut ants . ▁The ▁following ▁factors ▁are ▁the ▁harm ful ▁effects ▁of ▁li ver ▁expos ure ▁under ▁PM ▁or ▁C B . ▁First , ▁they ▁have ▁an ▁obvious ▁direct ▁to xic ▁effect ▁on ▁the ▁li ver . ▁Chem ical s ▁will ▁affect ▁met abol ism ▁and ▁impact ▁li ver ▁function . ▁Second , ▁infl amm ation ▁of ▁li ver ▁caused ▁by ▁ ▁PM ▁and ▁C B ▁impact ▁li pid ▁met abol ism ▁and ▁fat ty ▁li ver ▁disease . ▁Third , ▁PM ▁and ▁C B ▁can ▁trans loc ate ▁from ▁lung ▁to ▁li ver . ▁ ▁PM ▁and ▁C B ▁can ▁easily ▁trans loc ate ▁from ▁lung ▁to ▁li ver . ▁Because ▁they ▁are ▁very ▁diverse ▁and ▁each ▁has ▁different ▁to xic od ynam ics , ▁detailed ▁mechan isms ▁are ▁not ▁clear . ▁ ▁Water - sol ub le ▁fra ctions ▁of ▁PM ▁is ▁the ▁most ▁important ▁part ▁for ▁PM ▁trans location ▁to ▁li ver ▁through ▁extra - p ul mon ary ▁circul ation . ▁When ▁PM ▁goes