▁imp air ment ▁that ▁probably ▁cont ributes ▁to ▁a ▁decre ased ▁production ▁of ▁ext rac ell ular ▁matrix ▁prote ins ▁and ▁delayed ▁w ound ▁contra ction ▁and ▁imp a ired ▁w ound ▁he aling . ▁ ▁In cre ased ▁matrix ▁metal lo prote in ases ▁( M MP ) ▁activity ▁In ▁order ▁for ▁a ▁w ound ▁to ▁he al , ▁ext rac ell ular ▁matrix ▁not ▁only ▁needs ▁to ▁be ▁laid ▁down ▁but ▁also ▁must ▁be ▁able ▁to ▁under go ▁de grad ation ▁and ▁rem od eling ▁to ▁form ▁a ▁m ature ▁t issue ▁with ▁appropriate ▁tens ile ▁strength . ▁Prote ases , ▁namely ▁matrix ▁metal lo prote in ases ▁are ▁known ▁to ▁deg rade ▁almost ▁all ▁the ▁ext rac ell ular ▁matrix ▁components . ▁They ▁are ▁known ▁to ▁be ▁involved ▁in ▁fib ro blast ▁and ▁ker atin ocy te ▁migration , ▁t issue ▁re - organ ization , ▁infl amm ation ▁and ▁rem od eling ▁of ▁the ▁wounded ▁t issue . ▁Due ▁to ▁persist ently ▁high ▁concentr ations ▁of ▁pro - infl am mat ory ▁cy tok ines ▁in ▁di ab etic ▁ul cers , ▁M MP ▁activity ▁is ▁known ▁to ▁increase ▁by ▁ 3 0 ▁fol d ▁when ▁compared ▁to ▁ac ute ▁w ound ▁he aling . ▁M MP - 2 ▁and ▁M MP - 9 ▁show ▁sust ained ▁over expression ▁in ▁chron ic ▁non - he aling ▁di ab etic ▁ul cers . ▁Bal ance ▁in ▁the ▁M MP ▁activity ▁is ▁usually ▁achieved ▁by ▁t issue ▁in hib itor ▁of