▁orth olog s , ▁it ▁is ▁meant ▁to ▁display ▁the ▁span ▁in ▁which ▁there ▁are ▁orth olog s ▁and ▁the ▁divers ity ▁of ▁those ▁species . ▁ ▁M ole cular ▁evolution ▁ ▁UP F 0 5 7 5 ▁protein ▁C 1 9 orf 6 7 ▁consists ▁of ▁one ▁family ▁and ▁there ▁are ▁no ▁apparent ▁dup lications ▁throughout ▁the ▁evolution ▁of ▁UP F 0 5 7 5 ▁protein ▁C 1 9 orf 6 7 . ▁ ▁The ▁D U F 3 3 1 4 ▁region ▁of ▁the ▁gene ▁appears ▁to ▁have ▁diver ged ▁at ▁a ▁slower ▁rate ▁relative ▁to ▁the ▁rest ▁of ▁the ▁gene , ▁indicating ▁that ▁that ▁region ▁may ▁have ▁been ▁under going ▁pur ifying ▁selection ▁because ▁that ▁region ▁played ▁an ▁important ▁role ▁in ▁the ▁protein . ▁ ▁C lin ical ▁significance ▁ ▁In ▁one ▁case ▁study , ▁C 1 9 orf 6 7 ▁was ▁one ▁of ▁ 2 9 ▁gen es ▁on ▁chrom os ome ▁ 1 9 ▁lost ▁due ▁to ▁delet ions ▁caused ▁by ▁chrom os om al ▁re arr ang ements . ▁The ▁re arr ang ements ▁resulted ▁neural ▁development ▁issues ▁and ▁behavior al ▁ab normal ities , ▁although ▁it ▁is ▁not ▁known ▁whether ▁C 1 9 orf 6 7 ▁played ▁an ▁active ▁role ▁in ▁the ▁resulting ▁phen ot ypes . ▁In ▁a ▁different ▁study , ▁when ▁a ▁portion ▁of ▁chrom os ome ▁ 1 9 ▁that ▁also ▁included ▁C 1 9 orf 6 7 ▁was ▁deleted , ▁development al ▁issues ▁such ▁as ▁In tra uter ine ▁growth ▁restriction ,