▁report ▁on ▁the ▁safety ▁and ▁ph arm ac ok inet ics ▁of ▁ap atin ib ▁in ▁Human ▁clin ical ▁studies ▁con cludes ▁that ▁it ▁has ▁encourag ing ▁ant it um or ▁activity ▁across ▁a ▁broad ▁range ▁of ▁cancer ▁types . ▁ ▁Current ▁status ▁ ▁There ▁is ▁a ▁Ph ase ▁II / III ▁study ▁rec ruit ing ▁patients ▁in ▁China ▁to ▁determine ▁whether ▁ap atin ib ▁can ▁improve ▁pro gression ▁free ▁surv ival ▁compared ▁with ▁place bo ▁in ▁patients ▁with ▁met ast atic ▁g astr ic ▁car cin oma ▁who ▁have ▁failed ▁two ▁lines ▁of ▁chem other apy ▁( Se ptember , ▁ 2 0 0 9 ). ▁A pat in ib ▁was ▁approved ▁by ▁CF DA ▁in ▁December , ▁ 2 0 1 4 ▁for ▁patients ▁with ▁late - stage ▁g astr ic ▁car cin oma ▁in ▁China . ▁A ▁phase ▁IV ▁study ▁on ▁safety ▁of ▁A pat in ib ▁started ▁in ▁April , ▁ 2 0 1 5 . ▁The ▁study ▁a ims ▁to ▁rec ruit ▁ 2 , 0 0 0 ▁patients . ▁ ▁As ▁of ▁November , ▁ 2 0 1 0 , ▁two ▁additional ▁Ph ase ▁II ▁clin ical ▁studies ▁have ▁been ▁initi ated ▁for ▁ap atin ib ▁in ▁met ast atic ▁triple - negative ▁breast ▁cancer ▁patients ▁and ▁advanced ▁he pat oc ell ular ▁car cin oma . ▁ ▁On ▁March ▁ 7 , ▁ 2 0 1 1 , ▁B uk w ang ▁announced ▁that ▁it ▁file d ▁an ▁IN D ▁to ▁the ▁Korean ▁F DA ▁to