issue ▁protein ▁levels , ▁due ▁to ▁mus cle ▁and ▁b one ▁at ro phy , ▁and ▁high ▁blood ▁gl uc ose ▁levels . ▁S od ium ▁levels ▁also ▁see ▁an ▁increase ▁which ▁results ▁in ▁fluid ▁ret ention ▁in ▁t issues ▁and ▁elev ated ▁blood ▁pressure . ▁In ▁addition ▁to ▁hyper secret ion ▁of ▁cort is ol , ▁excess ▁and rog ens ▁are ▁secret ed . ▁In ▁females , ▁increased ▁secret ion ▁of ▁and rog ens , ▁such ▁as ▁test oster one , ▁results ▁in ▁mascul in ization ▁which ▁may ▁present ▁as ▁fa cial ▁hair ▁growth ▁and ▁a ▁deep ened ▁voice . ▁ ▁Tre at ment ▁for ▁C ushing ’ s ▁synd rome ▁a ims ▁to ▁reduce ▁the ▁high ▁levels ▁of ▁cort is ol ▁circul ating ▁through ▁the ▁human ▁body . ▁The ▁course ▁of ▁action ▁ultimately ▁depends ▁on ▁the ▁cause ▁of ▁the ▁hyper secret ion . ▁C ushing ’ s ▁can ▁be ▁induced ▁by ▁repeated ▁synth etic ▁ster oid ▁use ▁to ▁treat ▁infl am mat ory ▁dise ases , ▁or ▁it ▁can ▁also ▁be ▁caused ▁by ▁a ▁tum or ▁in ▁the ▁p itu it ary ▁g land ▁or ▁ad ren al ▁g land . ▁In ▁either ▁case , ▁treatment ▁may ▁rely ▁on ▁removal ▁of ▁the ▁tum or ▁or ▁of ▁the ▁ad ren al ▁g lands . ▁Without ▁the ▁ad ren al ▁g lands , ▁the ▁human ▁body ▁is ▁unable ▁to ▁supply ▁the ▁h orm ones ▁it ▁produces ▁and ▁therefore ▁requires ▁h orm one ▁replacement ▁ther apy . ▁ ▁Add ison ' s ▁D ise