▁is ▁very ▁likely ▁that ▁the ▁same ▁signal ing ▁path ways ▁are ▁involved ▁in ▁cell ▁migration ▁and ▁the ▁development ▁of ▁tum or ▁resistance ▁to ▁ther apy . <0x09> ▁ <0x09> ▁M igr ating ▁tum or ▁cells ▁( reg ard less ▁of ▁the ▁movement ’ s ▁type ) ▁are ▁more ▁resist ant ▁to ▁chem other apy ▁and ▁radi other apy ▁than ▁non - mov ing ▁cells . ▁This ▁is ▁largely ▁due ▁to ▁the ▁fact ▁that ▁migr ating ▁cells ▁tempor arily ▁lose ▁their ▁ability ▁to ▁divide . ▁It ▁is ▁also ▁the ▁fact ▁that ▁moving ▁tum or ▁cells ▁display ▁increased ▁activity ▁of ▁anti - ap opt otic ▁gen es , ▁which ▁causes ▁resistance ▁to ▁chem other ape ut ic ▁dru gs ▁aim ed ▁at ▁induction ▁of ▁program med ▁cell ▁death . ▁In ▁addition , ▁cells ▁in ▁the ▁E MT ▁state ▁are ▁known ▁to ▁also ▁exhib it ▁chem ores istance . ▁This ▁drug ▁resistance ▁is ▁due ▁to ▁induction , ▁during ▁E MT , ▁of ▁the ▁synth esis ▁of ▁the ▁ABC ▁family ▁prote ins ▁responsible ▁for ▁the ▁eff l ux ▁of ▁chem other ape ut ic ▁dru gs ▁out ▁of ▁the ▁cell . ▁The ▁main ▁trans cription ▁factors ▁that ▁trigger ▁E MT ▁and , ▁at ▁the ▁same ▁time , ▁posit ively ▁reg ulate ▁the ▁activity ▁of ▁ABC ▁trans por ters ▁include ▁T W IST 1 , ▁Sn ail , ▁etc . <0x09> ▁ <0x09> ▁Rec ently ▁obtained ▁data ▁indicate ▁strong ▁association ▁between ▁collect ive ▁migration ▁and ▁resistance ▁to ▁radi other apy ▁and ▁chem other apy . ▁According ▁to ▁our