▁is ▁an ▁en zym e ▁that ▁in ▁humans ▁is ▁encoded ▁by ▁the ▁D US P 1 0 ▁gene . ▁ ▁D ual ▁specific ity ▁protein ▁ph osph at ases ▁in activ ate ▁their ▁target ▁kin ases ▁by ▁de ph osph ory l ating ▁both ▁the ▁ph osph oser ine / th re on ine ▁and ▁ph osph oty ros ine ▁resid ues . ▁They ▁neg atively ▁reg ulate ▁members ▁of ▁the ▁M AP K ▁super family ▁( MA PK / ER K , ▁S AP K / J N K , ▁p 3 8 ), ▁which ▁is ▁associated ▁with ▁cell ular ▁pro l ifer ation ▁and ▁different iation . ▁D ifferent ▁members ▁of ▁this ▁family ▁of ▁dual ▁specific ity ▁ph osph at ases ▁show ▁distinct ▁substr ate ▁specific ities ▁for ▁M AP K s , ▁different ▁t issue ▁distribution ▁and ▁sub cell ular ▁local ization , ▁and ▁different ▁modes ▁of ▁indu ci b ility ▁of ▁their ▁expression ▁by ▁ext rac ell ular ▁stim uli . ▁This ▁gene ▁product ▁bind s ▁to ▁and ▁in activ ates ▁p 3 8 ▁and ▁S AP K / J N K , ▁but ▁not ▁M AP K / ER K . ▁Its ▁sub cell ular ▁local ization ▁is ▁unique ; ▁it ▁is ▁even ly ▁distributed ▁in ▁both ▁the ▁cy top las m ▁and ▁the ▁nucle us . ▁This ▁gene ▁is ▁widely ▁expressed ▁in ▁various ▁t issues ▁and ▁org ans , ▁and ▁its ▁expression ▁is ▁elev ated ▁by ▁stress ▁stim uli . ▁Three ▁trans cript ▁variants ▁encoding ▁two ▁different