▁es oph agit is , ▁non - cel iac ▁gl uten ▁sens itivity . ▁ ▁All erg ic ▁re actions ▁can ▁range ▁from ▁s ne ez ing ▁and ▁r hin or rho ea ▁to ▁an ap hy la xis ▁and ▁even ▁death . ▁ ▁Path oph ys i ology ▁In ▁an ▁all erg ic ▁reaction , ▁initial ▁expos ure ▁to ▁an ▁otherwise ▁har ml ess ▁ex ogen ous ▁subst ance ▁( known ▁as ▁an ▁aller gen ) ▁triggers ▁the ▁production ▁of ▁specific ▁Ig E ▁ant ib od ies ▁by ▁activ ated ▁B ▁cells . ▁These ▁Ig E ▁ant ib od ies ▁bind ▁to ▁the ▁surface ▁of ▁m ast ▁cells ▁via ▁high - aff inity ▁Ig E ▁re cept ors , ▁a ▁step ▁that ▁is ▁not ▁itself ▁associated ▁with ▁a ▁clin ical ▁response . ▁However , ▁upon ▁re - ex pos ure , ▁the ▁aller gen ▁bind s ▁to ▁memb rane - bound ▁Ig E ▁which ▁activ ates ▁the ▁m ast ▁cells , ▁re le asing ▁a ▁variety ▁of ▁medi ators . ▁This ▁type ▁I ▁hyp ers ens itivity ▁reaction ▁is ▁the ▁basis ▁of ▁the ▁sympt oms ▁of ▁all erg ic ▁re actions , ▁which ▁range ▁from ▁s ne ez ing ▁and ▁r hin or rho ea ▁to ▁an ap hy la xis . ▁All erg ens ▁can ▁be ▁a ▁number ▁of ▁different ▁subst ances , ▁for ▁example ▁pol len , ▁d ander , ▁dust ▁mit es , ▁food s . ▁ ▁C aus es ▁At op ic ▁re actions ▁are ▁caused ▁by ▁local