1 6 ▁Category : 2 0 1 6 ▁establish ments ▁in ▁China <0x0A> </s> ▁He par an ▁sul f ate ▁gl uc os am ine ▁ 3 - O - s ulf otr ans fer ase ▁ 2 ▁is ▁an ▁en zym e ▁that ▁in ▁humans ▁is ▁encoded ▁by ▁the ▁H S 3 ST 2 ▁gene . ▁ ▁He par an ▁sul f ate ▁b ios yn th etic ▁en zym es ▁are ▁key ▁components ▁in ▁generating ▁a ▁my ri ad ▁of ▁distinct ▁he par an ▁sul f ate ▁fine ▁structures ▁that ▁carry ▁out ▁multiple ▁bi olog ic ▁activities . ▁The ▁en zym e ▁encoded ▁by ▁this ▁gene ▁is ▁a ▁member ▁of ▁the ▁he par an ▁sul f ate ▁b ios yn th etic ▁en zym e ▁family . ▁It ▁is ▁a ▁type ▁II ▁integral ▁memb rane ▁protein ▁and ▁poss esses ▁he par an ▁sul f ate ▁gl uc os amin yl ▁ 3 - O - s ulf otr ans fer ase ▁activity . ▁This ▁gene ▁is ▁expressed ▁pre domin antly ▁in ▁brain ▁and ▁may ▁play ▁a ▁role ▁in ▁the ▁nerv ous ▁system . ▁ ▁Ro le ▁in ▁breast ▁cancer ▁The ▁H S 3 ST 2 ▁prom oter ▁is ▁hyper m eth yl ated ▁in ▁breast ▁cancer ▁t issue ▁compared ▁to ▁normal ▁breast ▁du ct s , ▁suggesting ▁a ▁potential ▁invol vement ▁in ▁the ▁path ogen esis ▁of ▁the ▁disease . ▁Function al ▁analysis ▁revealed ▁that ▁up reg ulation ▁of ▁H S 3 ST 2 ▁in ▁human ▁breast ▁cancer ▁cells ▁resulted ▁in