ary ▁met abol ites ▁by ▁the ▁non rib os om al ▁code ▁is ▁not ▁as ▁concrete ▁as ▁DNA / R NA ▁cod on - to - am ino ▁acid ▁and ▁much ▁research ▁is ▁still ▁needed ▁to ▁have ▁a ▁broad - use ▁code . ▁ ▁The ▁increasing ▁number ▁of ▁sequ enced ▁genom es ▁and ▁high - through put ▁prediction ▁software ▁has ▁allowed ▁for ▁better ▁el uc id ation ▁of ▁predicted ▁substr ate ▁specific ity ▁and ▁thus ▁natural ▁products / second ary ▁met abol ites . ▁ ▁En zym e ▁character ization ▁by , ▁for ▁example , ▁ATP - py roph osph ate ▁exchange ▁ass ays ▁for ▁substr ate ▁specific ity , ▁in ▁sil ico ▁substr ate - binding ▁pocket ▁mod elling ▁and ▁structure - function ▁mut agen esis ▁( in ▁vit ro ▁tests ▁or ▁in ▁sil ico ▁mod elling ) ▁helps ▁support ▁predict ive ▁algorithms . ▁ ▁Much ▁research ▁has ▁been ▁done ▁on ▁b acter ia ▁and ▁fung i , ▁with ▁pro k ary otic ▁b acter ia ▁having ▁easier - to - predict ▁products . ▁ ▁The ▁non rib os om al ▁pe pt ide ▁synth et ase ▁( NR PS ), ▁a ▁multi - mod ular ▁en zym e ▁complex , ▁minim ally ▁contains ▁repeating , ▁tri - dom ains ▁( aden yl ation ▁( A ), ▁pe pt id yl ▁car rier ▁protein ▁( P CP ) ▁and ▁last ly ▁cond ens ation ( C )). ▁The ▁ad en yl ation ▁domain ▁( A ) ▁is ▁the ▁focus ▁for ▁substr ate