es ion ▁binding ▁has ▁been ▁proven . ▁Bud ding ▁ye ast ▁la cks ▁repet itive ▁sequences ▁and , ▁therefore , ▁requires ▁a ▁different ▁mechanism ▁for ▁coh es ion ▁binding . ▁Ev idence ▁suggests ▁that ▁binding ▁of ▁coh es in ▁to ▁the ▁bud ding ▁ye ast ▁cent rom ere ▁region ▁depends ▁on ▁chrom os ome - associ ated ▁prote ins ▁of ▁the ▁k inet och ore ▁that ▁medi ate ▁coh es ion ▁association ▁to ▁per ic ent ric ▁regions ▁( the ▁k inet och ore ▁is ▁an ▁en han cer ▁of ▁per ic ent ric ▁coh es in ▁binding ). ▁ ▁C oh es in ▁and ▁CT CF ▁Many ▁chrom atin ▁loops ▁are ▁formed ▁by ▁so ▁called ▁loop ▁extr usion ▁mechanism , ▁when ▁the ▁coh es in ▁ring ▁moves ▁act ively ▁along ▁the ▁two ▁DNA ▁double ▁hel ices , ▁trans loc ating ▁one ▁of ▁them ▁with ▁respect ▁to ▁the ▁other . ▁Thus , ▁the ▁loop ▁can ▁become ▁smaller ▁or ▁larger . ▁The ▁loop ▁extr usion ▁process ▁stops ▁when ▁coh es in ▁enc oun ters ▁the ▁architect ural ▁chrom atin ▁protein ▁CT CF . ▁The ▁CT CF ▁site ▁needs ▁to ▁be ▁in ▁a ▁proper ▁orientation ▁to ▁stop ▁coh es in . ▁ ▁Me ios is ▁ ▁C oh es in ▁prote ins ▁S MC 1 ß , ▁S MC 3 , ▁RE C 8 ▁and ▁S TAG 3 ▁appear ▁to ▁particip ate ▁in ▁coh es ion ▁of ▁sister ▁chrom at ids ▁throughout ▁the ▁me i otic ▁process ▁in ▁human ▁o ocy tes . ▁ ▁S