ions . ▁Non - rem ov able ▁pressure ▁rel ieving ▁inter vent ions , ▁including ▁non - rem ov able ▁cast s ▁with ▁an ▁Ach illes ▁tend on ▁length ening ▁component , ▁were ▁found ▁to ▁be ▁more ▁effective ▁at ▁he aling ▁foot ▁ul cers ▁related ▁to ▁di ab etes ▁that ▁th era pe ut ic ▁sho es ▁and ▁other ▁pressure ▁rel ieving ▁approaches . ▁ ▁Hyper bar ic ▁o xygen ▁In ▁ 2 0 1 5 , ▁a ▁C och rane ▁review ▁concluded ▁that ▁for ▁people ▁with ▁di ab etic ▁foot ▁ul cers , ▁hyper bar ic ▁o xygen ▁ther apy ▁reduced ▁the ▁risk ▁of ▁am putation ▁and ▁may ▁improve ▁the ▁he aling ▁at ▁ 6 ▁weeks . ▁However , ▁there ▁was ▁no ▁benefit ▁at ▁one ▁year ▁and ▁the ▁quality ▁of ▁the ▁review ed ▁tri als ▁was ▁in ade qu ate ▁to ▁draw ▁strong ▁conclus ions . ▁ ▁Neg ative ▁pressure ▁w ound ▁ther apy ▁ ▁This ▁treatment ▁uses ▁vac u um ▁to ▁remove ▁excess ▁fluid ▁and ▁cell ular ▁waste ▁that ▁usually ▁prolong ▁the ▁infl am mat ory ▁phase ▁of ▁w ound ▁he aling . ▁Despite ▁a ▁straightforward ▁mechanism ▁of ▁action , ▁results ▁of ▁negative ▁pressure ▁w ound ▁ther apy ▁studies ▁have ▁been ▁incons istent . ▁Research ▁needs ▁to ▁be ▁carried ▁out ▁to ▁optimize ▁the ▁parameters ▁of ▁pressure ▁intensity , ▁treatment ▁intervals ▁and ▁exact ▁timing ▁to ▁start ▁negative ▁pressure ▁ther apy ▁in ▁the ▁course ▁of ▁chron ic ▁w ound ▁he aling . ▁ ▁Other ▁treat ments ▁ ▁O zone ▁ther apy ▁– ▁there