▁suitable ▁collection ▁of ▁comp ounds ▁and ▁an ▁appropriate ▁model ▁system ▁for ▁screen ing ▁the ▁comp ounds ▁and ▁looking ▁for ▁the ▁parallel ▁identification ▁of ▁bi ological ▁targets ▁and ▁bi olog ically ▁active ▁comp ounds . ▁ ▁The ▁bi olog ically ▁active ▁comp ounds ▁that ▁are ▁discovered ▁through ▁forward ▁or ▁reverse ▁chem ogen om ics ▁approaches ▁are ▁known ▁as ▁mod ul ators ▁because ▁they ▁bind ▁to ▁and ▁mod ulate ▁specific ▁mole cular ▁targets , ▁thus ▁they ▁could ▁be ▁used ▁as ▁‘ target ed ▁th era pe ut ics ’ . ▁ ▁For ward ▁chem ogen om ics ▁▁ ▁In ▁forward ▁chem ogen om ics , ▁which ▁is ▁also ▁known ▁as ▁classical ▁chem ogen om ics , ▁a ▁particular ▁phen ot ype ▁is ▁studied ▁and ▁small ▁comp ound ▁interact ing ▁with ▁this ▁function ▁are ▁identified . ▁ ▁The ▁mole cular ▁basis ▁of ▁this ▁desired ▁phen ot ype ▁is ▁unknown . ▁ ▁Once ▁the ▁mod ul ators ▁have ▁been ▁identified , ▁they ▁will ▁be ▁used ▁as ▁tools ▁to ▁look ▁for ▁the ▁protein ▁responsible ▁for ▁the ▁phen ot ype . ▁ ▁For ▁example , ▁a ▁loss - of - function ▁phen ot ype ▁could ▁be ▁an ▁arrest ▁of ▁tum or ▁growth . ▁ ▁Once ▁comp ounds ▁that ▁lead ▁to ▁a ▁target ▁phen ot ype ▁have ▁been ▁identified , ▁ident ifying ▁the ▁gene ▁and ▁protein ▁targets ▁should ▁be ▁the ▁next ▁step . ▁The ▁main ▁challenge ▁of ▁forward ▁chem ogen om ics ▁strategy ▁lies ▁in ▁design ing ▁phen ot yp ic ▁ass ays ▁that ▁lead ▁immediately ▁from ▁screen ing ▁to