ly ▁activ ate ▁the ▁AR . ▁Fl ut am ide ▁has ▁far ▁lower ▁aff inity ▁for ▁the ▁AR ▁than ▁do ▁ster oid al ▁anti and rog ens ▁like ▁spir on ol act one ▁and ▁cy pro ter one ▁ac et ate , ▁and ▁it ▁is ▁a ▁relatively ▁weak ▁anti andro gen ▁in ▁terms ▁of ▁pot ency ▁by ▁weight , ▁but ▁the ▁large ▁dos ages ▁at ▁which ▁fl ut am ide ▁is ▁used ▁appear ▁to ▁compens ate ▁for ▁this . ▁In ▁accord ance ▁with ▁its ▁select ivity ▁for ▁the ▁AR , ▁fl ut am ide ▁does ▁not ▁interact ▁with ▁the ▁pro g ester one , ▁est ro gen , ▁gl uc oc ort ico id , ▁or ▁min eral oc ort ico id ▁re ceptor , ▁and ▁poss esses ▁no ▁intr insic ▁pro gest ogen ic , ▁est ro gen ic , ▁gl uc oc ort ico id , ▁or ▁ant ig on ad otrop ic ▁activity . ▁However , ▁it ▁can ▁have ▁some ▁indirect ▁est ro gen ic ▁effects ▁via ▁increased ▁levels ▁of ▁est rad i ol ▁secondary ▁to ▁AR ▁block ade , ▁and ▁this ▁involved ▁in ▁the ▁gy ne com ast ia ▁it ▁can ▁produce . ▁Because ▁fl ut am ide ▁does ▁not ▁have ▁any ▁est ro gen ic , ▁pro gest ogen ic , ▁or ▁ant ig on ad otrop ic ▁activity , ▁the ▁medic ation ▁does ▁not ▁cause ▁men stru al ▁irregular ities ▁in ▁women . ▁This ▁is ▁in ▁contrast ▁to ▁ster oid al ▁anti and rog ens ▁like ▁spir