▁new ▁bond ▁in ▁protect ing ▁the ▁react ivity ▁of ▁GP X 1 . ▁ ▁Animal ▁studies ▁▁ ▁GP X 1 ▁helps ▁to ▁prevent ▁card iac ▁d ys function ▁after ▁is chem ia - re per f usion ▁inj uries . ▁M ito ch ond rial ▁R OS ▁production ▁and ▁ox id ative ▁m t D NA ▁damage ▁is ▁increased ▁during ▁re ox y gen ation ▁in ▁the ▁GP X 1 ▁knock out ▁m ice , ▁in ▁addition ▁to ▁struct ural ▁ab normal ities ▁in ▁card iac ▁mit och ond ria ▁and ▁my ocy tes , ▁suggesting ▁GP X 1 ▁may ▁play ▁an ▁important ▁role ▁in ▁protect ing ▁card iac ▁mit och ond ria ▁from ▁re ox y gen ation ▁damage ▁in ▁v ivo . ▁ ▁In ▁GP X 1 ▁(- / -) ▁m ice , ▁ox id ant ▁formation ▁is ▁increased , ▁end oth el ial ▁NO ▁synth ase ▁is ▁der eg ulated , ▁and ▁ad hes ion ▁of ▁le uk ocy tes ▁to ▁cult ured ▁end oth el ial ▁cells ▁is ▁increased . ▁Ex perimental ▁GP X 1 ▁def ic iency ▁ampl ifies ▁certain ▁aspects ▁of ▁ag ing , ▁namely ▁end oth el ial ▁d ys function , ▁v asc ular ▁rem od eling , ▁and ▁invasion ▁of ▁le uk ocy tes ▁in ▁card i ov asc ular ▁t issue . ▁ ▁C lin ical ▁significance ▁▁ ▁The ▁GP x 1 ▁alle le ▁with ▁five ▁A la ▁repe ats ▁is ▁significantly ▁associated ▁with ▁breast ▁cancer ▁risk . ▁ ▁K oc ab as