2 0 1 1 . ▁It ▁is ▁unclear ▁who ▁AB - 0 0 1 ▁was ▁originally ▁developed ▁by , ▁but ▁it ▁is ▁struct ur ally ▁related ▁to ▁comp ounds ▁such ▁as ▁AM - 1 2 4 8 ▁and ▁its ▁corresponding ▁ 1 -( t et rah yd ropy ran - 4 - yl m eth yl ) ▁analog ue , ▁which ▁are ▁known ▁to ▁be ▁pot ent ▁can nab ino id ▁ag on ists ▁with ▁moder ate ▁to ▁high ▁select ivity ▁for ▁C B 2 ▁over ▁C B 1 . ▁The ▁first ▁published ▁synth esis ▁and ▁ph arm ac ological ▁evaluation ▁of ▁AB - 0 0 1 ▁revealed ▁that ▁it ▁acts ▁as ▁a ▁full ▁ag on ist ▁at ▁C B 1 ▁( EC 5 0 ▁= ▁ 3 5 ▁n M ) ▁and ▁C B 2 ▁re cept ors ▁( EC 5 0 ▁= ▁ 4 8 ▁n M ). ▁However , ▁AB - 0 0 1 ▁was ▁found ▁to ▁possess ▁only ▁weak ▁can nab im im etic ▁effects ▁in ▁r ats ▁at ▁dos es ▁up ▁to ▁ 3 0   m g / kg , ▁making ▁it ▁less ▁pot ent ▁than ▁the ▁car box am ide ▁analog ue ▁API CA , ▁which ▁poss esses ▁pot ent ▁can nab im im etic ▁activity ▁at ▁dos es ▁of ▁ 3   m g / kg . ▁ ▁See ▁also ▁▁ ▁A - 8 3 4 , 7 3 5 ▁ ▁AB - 0 0 5 ▁ ▁AM - 1 2 4 8 ▁ ▁API