▁“ Ch em ical ▁Kin etic ▁Me asure ments ▁of ▁a ▁M amm al ian ▁Ac et yl ch oline ▁Re ceptor ▁by ▁a ▁Fast - Re action ▁Te chni que .” ▁ ▁In ▁ 1 9 9 5 ▁he ▁pione ered ▁the ▁use ▁of ▁yet ▁another ▁revolution ary ▁technique , ▁las er - p ulse ▁phot ol ysis , ▁that ▁allowed ▁the ▁visual ization ▁of ▁results ▁down ▁to ▁the ▁micro second .   ▁He ▁used ▁this ▁technique ▁for ▁further ▁studies ▁on ▁the ▁effects ▁of ▁c oca ine ▁on ▁the ▁ac et yl ch oline ▁re ceptor , ▁foc using ▁on ▁the ▁mus cular ▁effects ▁of ▁ac et yl ch oline ▁re ceptor ▁in hib ition , ▁rather ▁than ▁the ▁ne uro log ical ▁effects .   ▁His ▁results ▁were ▁published ▁in ▁his ▁ 1 9 9 5 ▁paper : ▁“ C oca ine : ▁Mechan ism ▁of ▁In hib ition ▁of ▁a ▁Mus cle ▁Ac et yl ch oline ▁Re ceptor ▁Stud ied ▁by ▁a ▁Las er - P ulse ▁Phot ol ysis ▁Te chni que .” ▁ ▁Other ▁research ▁ ▁Though ▁most ▁of ▁his ▁research ▁focused ▁on ▁ac et yl ch oline ▁re cept ors , ▁H ess ▁worked ▁on ▁a ▁wide ▁variety ▁of ▁subjects ▁during ▁his ▁time ▁at ▁Corn ell .   ▁His ▁ 1 9 6 2 ▁paper ▁“ Con form ational ▁Ch anges ▁in ▁En zym e ▁Catal yst s ” ▁provided ▁some ▁of ▁the ▁first ▁evidence ▁that ▁en zym e ▁catal yst s ▁under go ▁conform ational