▁with ▁an ▁or al ▁contra cept ive ▁produced ▁a ▁marked ▁decrease ▁in ▁hair ▁loss ▁scores ▁after ▁ 1   year ▁of ▁treatment , ▁with ▁maximum ▁effect ▁after ▁ 2   year s ▁of ▁treatment ▁and ▁benefits ▁maintained ▁for ▁another ▁ 2   year s . ▁In ▁a ▁small ▁study ▁of ▁fl ut am ide ▁with ▁an ▁or al ▁contra cept ive , ▁the ▁medic ation ▁caused ▁an ▁increase ▁in ▁cos met ically ▁accept ance ▁hair ▁density ▁in ▁ 6 ▁of ▁ 7   w omen ▁with ▁diff use ▁scal p ▁hair ▁loss . ▁In ▁a ▁compar ative ▁study , ▁fl ut am ide ▁significantly ▁improved ▁scal p ▁hair ▁growth ▁( 2 1 % ▁reduction ▁in ▁Ludwig ▁scores ) ▁in ▁hyper andro gen ic ▁women ▁after ▁ 1   year ▁of ▁treatment , ▁whereas ▁cy pro ter one ▁ac et ate ▁and ▁fin aster ide ▁were ▁in effect ive . ▁ ▁Trans gender ▁h orm one ▁ther apy ▁Fl ut am ide ▁has ▁been ▁used ▁as ▁a ▁component ▁of ▁femin izing ▁h orm one ▁ther apy ▁for ▁trans gender ▁women . ▁At ▁least ▁two ▁cent ers ▁have ▁been ▁reported ▁to ▁use ▁fl ut am ide ▁as ▁an ▁anti andro gen ▁in ▁trans gender ▁women . ▁However , ▁the ▁use ▁of ▁fl ut am ide ▁for ▁such ▁purposes , ▁as ▁well ▁as ▁in ▁c is gender ▁women ▁with ▁and ro gen - dependent ▁der mat ological ▁conditions , ▁is ▁disc ou rag ed ▁due ▁to ▁reports ▁of ▁he pat ot ox icity ▁in ▁men ▁with