ney ▁and ▁brain ▁than ▁human . ▁ ▁In ▁m ice , ▁only ▁normal ▁kid ney ▁and ▁pro state ▁tum ors ▁were ▁im aged , ▁and ▁not ▁other ▁t issues , ▁not ▁even ▁C NS ▁suggesting ▁the ▁impr ort ance ▁of ▁the ▁blood – bra in ▁bar rier . ▁In ▁kid ney , ▁a ▁subset ▁of ▁tub ules ▁contain ▁PS MA . ▁Thus , ▁imag ing ▁studies ▁must ▁be ▁performed ▁in ▁humans ▁with ▁low - m ole cular - weight ▁lig ands ▁to ▁define ▁their ▁potential ▁for ▁imag ing ▁and ▁target ing . ▁ ▁Th era pe ut ic ▁target ▁ ▁PS MA ▁is ▁the ▁target ▁of ▁several ▁nuclear ▁medicine ▁imag ing ▁agents ▁for ▁pro state ▁cancer . ▁Cap rom ab pent ide ▁( market ed ▁as ▁PRO ST ASC INT ) ▁is ▁bound ▁to ▁ind ium - 1 1 1 ▁for ▁detection ▁by ▁a ▁g amma ▁camera . ▁ ▁Second - gener ation ▁ant ib od ies ▁and ▁low - m ole cular - weight ▁lig ands ▁for ▁imag ing ▁and ▁ther apy ▁are ▁under ▁development . ▁ ▁PS MA ▁can ▁also ▁be ▁used ▁experiment ally ▁to ▁target ▁treatment . ▁L ut et ium - 1 7 7 ▁is ▁a ▁beta ▁em itter , ▁bound ▁to ▁PS MA ▁to ▁deliver ▁treat ▁pro state ▁tum ours . ▁ ▁In ▁addition ▁to ▁the ▁human ▁pro state ▁and ▁pro state ▁cancer , ▁PS MA ▁is ▁highly ▁expressed ▁in ▁tum or ▁ne ov as cul ature , ▁but ▁not ▁corresponding ▁normal ▁vas cul ature ▁of ▁all ▁types