- e ight ▁her edit ary ▁dis orders , ▁possibly ▁some ▁more ▁as ▁yet ▁unknown . ▁Sym pt oms ▁can ▁include ▁g out , ▁an a emia , ▁ep ile ps y , ▁delayed ▁development , ▁de af ness , ▁comp uls ive ▁self - bit ing , ▁kid ney ▁failure ▁or ▁stones , ▁or ▁loss ▁of ▁imm unity . ▁ ▁Pur ine ▁met abol ism ▁can ▁have ▁im bal ances ▁that ▁can ▁arise ▁from ▁harm ful ▁nucle ot ide ▁tri ph osph osph ates ▁incorpor ating ▁into ▁DNA ▁and ▁R NA ▁which ▁further ▁lead ▁to ▁gen etic ▁dist urban ces ▁and ▁mut ations , ▁and ▁as ▁a ▁result , ▁give ▁rise ▁to ▁several ▁types ▁of ▁dise ases . ▁Some ▁of ▁the ▁dise ases ▁are : ▁ ▁Se vere ▁imm un ode fic iency ▁by ▁loss ▁of ▁ad en os ine ▁de amin ase . ▁Hyper ur ic emia ▁and ▁L esch – N y han ▁synd rome ▁by ▁the ▁loss ▁of ▁hy po x anth ine - gu an ine ▁ph osph or ib os yl trans fer ase . ▁D ifferent ▁types ▁of ▁cancer ▁by ▁an ▁increase ▁in ▁the ▁activities ▁of ▁en zym es ▁like ▁I MP ▁de h ydro gen ase . ▁ ▁Ph arm ac other apy ▁Mod ulation ▁of ▁pur ine ▁met abol ism ▁has ▁ph arm ac other ape ut ic ▁value . ▁ ▁Pur ine ▁synth esis ▁in hib itors ▁in hib it ▁the ▁pro l ifer ation ▁of ▁cells , ▁especially ▁le uk ocy tes