▁protein ▁encoded ▁by ▁this ▁gene ▁functions ▁as ▁a ▁half - trans porter ▁to ▁limit ▁int est inal ▁absor ption ▁and ▁promote ▁b ili ary ▁ex cret ion ▁of ▁ster ols . ▁It ▁is ▁expressed ▁in ▁a ▁t issue - specific ▁manner ▁in ▁the ▁li ver , ▁colon , ▁and ▁int est ine . ▁This ▁gene ▁is ▁tan dem ly ▁array ed ▁on ▁chrom os ome ▁ 2 , ▁in ▁a ▁head - to - head ▁orientation ▁with ▁family ▁member ▁ABC G 8 . ▁Mut ations ▁in ▁this ▁gene ▁may ▁contribute ▁to ▁ster ol ▁accum ulation ▁and ▁a ther os cl eros is , ▁and ▁have ▁been ▁observed ▁in ▁patients ▁with ▁sit ost ero lem ia . ▁ ▁Inter active ▁path way ▁map ▁ ▁See ▁also ▁▁ ▁ABC G 5 ▁and ▁ABC G 8 ▁Gen es ▁ ▁References ▁ ▁Further ▁reading ▁ ▁External ▁links ▁▁▁▁▁▁ ▁Category : ABC ▁trans por ters <0x0A> </s> ▁George ▁How arth ▁( 1 8 5 4 ▁– ▁ 2 8 ▁June ▁ 1 9 0 8 ) ▁was ▁an ▁English - born ▁Australian ▁politician . ▁ ▁He ▁was ▁born ▁in ▁Kent , ▁and ▁became ▁a ▁mar iner ▁before ▁eventually ▁sett ling ▁in ▁Sydney ▁in ▁ 1 8 8 3 . ▁He ▁worked ▁as ▁a ▁w ool ▁press er ▁on ▁the ▁L ach lan ▁River ▁and ▁at ▁Bool ig al ▁before ▁becoming ▁a ▁staff ▁survey or ▁and ▁then ▁a ▁but cher . ▁On ▁ 2 6 ▁January ▁ 1 8 9 1 ▁he ▁married ▁Ellen ▁Elizabeth ▁Hamm ond ; ▁they