▁larger ▁number ▁of ▁cell ular ▁mole cules ▁in ▁its ▁implementation ▁( Fig . ▁ 1 ). <0x09> ▁ <0x09> ▁This ▁type ▁of ▁migration ▁is ▁typical ▁of ▁ker atin ocy tes ▁during ▁re par ative ▁reg ener ation , ▁end oth eli ocy tes , ▁smooth ▁mus cle ▁cells , ▁and ▁fib ro bl asts . ▁Since ▁m align ant ▁cells , ▁which ▁use ▁the ▁mes en ch ym al ▁type ▁of ▁movement , ▁lose ▁ep ith el ial ▁polar ity ▁and ▁gain ▁an ▁el ong ated ▁sp ind le ▁shape , ▁which ▁res emb les ▁the ▁fib ro blast ▁shape , ▁invasion ▁of ▁this ▁type ▁is ▁also ▁called ▁“ f ib ro blast - like ” ▁migration . ▁M esen ch ym al ▁invasion ▁has ▁been ▁detected ▁during ▁the ▁development ▁of ▁mel an oma , ▁fib ros ar com a , ▁gli ob last oma , ▁and ▁other ▁m align an cies . <0x09> ▁ <0x09> ▁Most ▁of ▁the ▁cancer ▁cells ▁that ▁det ach ▁from ▁the ▁tum or ▁mass ▁and ▁in va de ▁the ▁surrounding ▁t issues ▁are ▁known ▁to ▁under go ▁certain ▁changes , ▁acqu iring ▁the ▁morph ological ▁properties ▁and ▁a ▁phen ot ype ▁typical ▁of ▁mes en ch ym al ▁cells . ▁This ▁transformation ▁of ▁a ▁m align ant ▁ep ith el ial ▁cell , ▁which ▁is ▁related ▁to ▁the ▁emer gence ▁of ▁new ▁mole cular ▁and ▁morph ological ▁features ▁in ▁the ▁cell , ▁was ▁called ▁the ▁“ ep ith el ial - ▁mes en ch ym al ▁transition .”