ib acter ial ▁so aps , ▁and ▁chemical ▁dis in fect ants , ▁whereas ▁ant ib iot ics ▁are ▁an ▁important ▁class ▁of ▁ant ib acter ial s ▁used ▁more ▁specifically ▁in ▁medicine ▁and ▁sometimes ▁in ▁liv est ock ▁feed . ▁ ▁Ant ib iot ics ▁have ▁been ▁used ▁since ▁ancient ▁times . ▁Many ▁civil izations ▁used ▁top ical ▁application ▁of ▁m ould y ▁bread , ▁with ▁many ▁references ▁to ▁its ▁benef icial ▁effects ▁ar ising ▁from ▁ancient ▁Egypt , ▁China , ▁Ser bia , ▁Greece , ▁and ▁Rome . ▁The ▁first ▁person ▁to ▁directly ▁document ▁the ▁use ▁of ▁m ould s ▁to ▁treat ▁in fe ctions ▁was ▁John ▁Park inson ▁( 1 5 6 7 – 1 6 5 0 ). ▁Ant ib iot ics ▁revolution ized ▁medicine ▁in ▁the ▁ 2 0 th ▁century . ▁Alexander ▁F lem ing ▁( 1 8 8 1 – 1 9 5 5 ) ▁discovered ▁modern ▁day ▁pen ic ill in ▁in ▁ 1 9 2 8 , ▁the ▁w ides p read ▁use ▁of ▁which ▁proved ▁significantly ▁benef icial ▁during ▁w art ime . ▁However , ▁the ▁effect iveness ▁and ▁easy ▁access ▁to ▁ant ib iot ics ▁have ▁also ▁led ▁to ▁their ▁over use ▁and ▁some ▁b acter ia ▁have ▁evol ved ▁resistance ▁to ▁them . ▁The ▁World ▁Health ▁Organ ization ▁has ▁class ified ▁ant im icro b ial ▁resistance ▁as ▁a ▁w ides p read ▁" ser ious ▁threat ▁[ that ] ▁is ▁no ▁longer ▁a ▁prediction ▁for ▁the ▁future , ▁it ▁is