ological )). ▁Regional ▁( local ) ▁stress ▁forms ▁with ▁participation ▁of ▁not ▁one ▁but ▁several ▁t issues ▁making ▁up ▁an ▁organ ▁or ▁a ▁body ▁part . ▁This ▁is ▁why ▁it ▁can ▁be ▁believed ▁that ▁regional ▁stress - re action ▁is ▁realized ▁with ▁the ▁participation ▁of ▁effect ors ▁of ▁int ra organ ▁inter t issue ▁interactions . ▁Finally , ▁the ▁cell ▁stress ▁is ▁realized ▁via ▁int rac ell ular ▁mechan isms , ▁without ▁any ▁participation ▁of ▁inter cell ular ▁interactions . ▁In ▁the ▁latter ▁case ▁the ▁C UR D ▁formation ▁and ▁synth esis ▁of ▁heat ▁shock ▁prote ins ▁act ▁as ▁“ self - def ense ” ▁mechanism ▁of ▁the ▁cell . ▁ ▁Another ▁distinct ive ▁feature ▁of ▁t issue ▁stress ▁is ▁the ▁principle ▁of ▁formation ▁of ▁its ▁executive ▁mechanism , ▁the ▁C UR D , ▁via ▁t issues pec ific ▁self - dam age ▁of ▁hom olog ous ▁t issue ▁cells . ▁Despite ▁the ▁fact ▁that ▁T AS , ▁just ▁as ▁the ▁cell ▁stress , ▁is ▁realized ▁via ▁C UR D , ▁the ▁T AS ▁has ▁a ▁variety ▁of ▁features ▁which ▁distinguish ▁it ▁from ▁the ▁cell ▁stress , ▁the ▁key ▁one ▁being ▁the ▁t issue - select ivity ▁of ▁C UR D ▁init iation ▁under ▁T AS ▁effect ors ▁influence . ▁In ▁addition , ▁under ▁cell ▁stress ▁the ▁cell ▁protection ▁is ▁realized ▁with ▁C UR D ▁participation ▁only ▁via ▁“ pass ive ” ▁mechanism . ▁It ▁consists ▁in ▁the ▁formation ▁of ▁the ▁protect ive ▁phase ▁of ▁this ▁phys i ological ▁reaction . ▁Meanwhile ,