▁and ▁alpha ▁ 2 - anti pl as min ▁have ▁been ▁imp licated ▁in ▁the ▁met abol ic ▁synd rome ▁and ▁various ▁other ▁disease ▁states . ▁ ▁However , ▁acquired ▁disturb ance ▁of ▁f ibr in ol ysis ▁( Hy per f ibr in ol ysis ), ▁is ▁not ▁un common . ▁Many ▁tra uma ▁patients ▁suffer ▁from ▁an ▁over wh el ming ▁activation ▁of ▁t issue ▁factor ▁and ▁thus ▁massive ▁hyper f ibr in ol ysis . ▁Also ▁in ▁other ▁disease ▁states ▁hyper f ibr in ol ysis ▁may ▁occur . ▁It ▁could ▁lead ▁to ▁massive ▁ble eding ▁if ▁not ▁diagn osed ▁and ▁treated ▁early ▁enough . ▁ ▁The ▁f ibr in ol yt ic ▁system ▁is ▁closely ▁linked ▁to ▁control ▁of ▁infl amm ation , ▁and ▁plays ▁a ▁role ▁in ▁disease ▁states ▁associated ▁with ▁infl amm ation . ▁ ▁Pl as min , ▁in ▁addition ▁to ▁l ys ing ▁f ibr in ▁cl ots , ▁also ▁cle aves ▁the ▁complement ▁system ▁component ▁C 3 , ▁and ▁f ibr in ▁de grad ation ▁products ▁have ▁some ▁v asc ular ▁per me ability ▁indu cing ▁effects . ▁ ▁Ph arm ac ology ▁In ▁a ▁process ▁called ▁th rom bol ysis ▁( the ▁break down ▁of ▁a ▁th rom bus ), ▁f ibr in ol yt ic ▁dru gs ▁are ▁used . ▁They ▁are ▁given ▁following ▁a ▁heart ▁attack ▁to ▁dissol ve ▁the ▁th rom bus ▁blocking ▁the ▁coron ary ▁ar tery ; ▁ ▁experiment ally ▁after ▁a ▁stroke ▁to ▁allow ▁blood ▁flow ▁back