oth el ial ▁cells ▁highly ▁express ▁M AP 4 K 4 ▁and ▁recent ▁studies ▁have ▁reported ▁that ▁M AP 4 K 4 ▁enh ances ▁end oth el ial ▁per me ability . ▁This ▁consequ ently ▁cont ributes ▁to ▁the ▁development ▁of ▁a ther os cl eros is ▁due ▁to ▁the ▁promotion ▁of ▁le uk ocy te ▁extra vas ation , ▁transport ▁of ▁ox id ized ▁lip ids ▁and ▁the ▁formation ▁of ▁pla ques . ▁ ▁Sil encing ▁of ▁end oth el ial ▁M AP 4 K 4 ▁am el ior ated ▁the ▁development ▁of ▁a ther os cl eros is ▁in ▁m ice . ▁Additionally , ▁treatment ▁of ▁a ▁M AP 4 K 4 ▁protein ▁kin ase ▁in hib itor ▁in ▁m ice ▁significantly ▁reduced ▁pla que ▁pro gression ▁and ▁promoted ▁pla que ▁regression ▁suggesting ▁th era pe ut ic ▁target ing ▁of ▁M AP 4 K 4 ▁may ▁be ▁a ▁benef icial ▁strategy ▁for ▁card i ov asc ular ▁disease . ▁ ▁Can cer ▁ ▁The ▁biggest ▁causes ▁of ▁death ▁for ▁patients ▁with ▁cancer ▁are ▁tum our ▁invasion ▁and ▁met ast asis ▁– ▁processes ▁that ▁are ▁highly ▁correl ated ▁with ▁cell ▁migration ▁and ▁mot ility . ▁There ▁is ▁limited ▁information ▁regarding ▁how ▁M AP 4 K 4 ▁is ▁involved ▁in ▁cancer ▁but ▁studies ▁have ▁shown ▁that ▁M AP 4 K 4 ▁is ▁over ex pressed ▁in ▁a ▁number ▁of ▁cancer ▁types ▁including ▁lung , ▁pro state , ▁pan cre atic ▁and ▁o var ian ▁cancer ▁where ▁such ▁up - reg ulation ▁is