▁am o eb oid ▁migration , ▁in ▁the ▁cell ’ s ▁shape ▁and ▁by ▁minimal ▁de formation ▁of ▁the ▁nucle us . ▁Of ▁clear ▁interest ▁are ▁the ▁results ▁of ▁studies ▁that ▁indicate ▁that ▁the ▁behavior ▁of ▁tum or ▁cells ▁during ▁individual ▁migration ▁depends ▁on ▁the ▁surrounding ▁matrix ’ ▁st iff ness . ▁For ▁example , ▁the ▁mes en ch ym al ▁or ▁prote ol yt ic ▁model ▁of ▁migration ▁domin ates ▁under ▁conditions ▁of ▁a ▁“ st iff ” ▁( “ den se ” ) ▁surrounding ▁matrix . ▁The ▁high ▁migration ▁efficiency ▁of ▁a ▁single ▁cell ▁using ▁the ▁mes en ch ym al ▁mechanism ▁in ▁dense ▁t issues ▁is ▁explained ▁by ▁prote ol ysis ▁due ▁to ▁the ▁secret ion ▁of ▁various ▁prote ases ▁and ▁by ▁the ▁ability ▁to ▁form ▁foc al ▁contacts ▁with ▁st rom al ▁elements . <0x09> ▁ <0x09> ▁Therefore , ▁it ▁is ▁worth ▁not ing ▁that ▁the ▁key ▁points ▁of ▁the ▁fib ro blast - like ▁mechanism ▁of ▁invas ive ▁growth ▁are ▁strong ▁ad hes ion ▁forces ▁on ▁both ▁pol es ▁of ▁the ▁cell ▁as ▁well ▁as ▁between ▁cells ▁and ▁ext rac ell ular ▁matrix ▁components , ▁pron ounced ▁expression ▁of ▁integr ins ▁( β 1 ▁and ▁ β 3 ▁families ), ▁prote ol ysis ▁with ▁destruction ▁and ▁subsequent ▁rem od eling ▁of ▁t issues ▁with ▁the ▁formation ▁of ▁defect s ▁in ▁the ▁matrix ▁structure , ▁and ▁movement ▁of ▁a ▁single ▁cell ▁or ▁cell ▁ch ains ▁through ▁the ▁defect s . ▁The ▁nucle us ▁de formation ▁is ▁minimal , ▁and