▁to ▁central ▁core ▁disease ▁( CC D ), ▁an ▁aut os om al ▁dominant ▁dis order ▁character ized ▁both ▁by ▁M H ▁sympt oms ▁and ▁by ▁my op ath y . ▁M H ▁is ▁usually ▁un mask ed ▁by ▁an est hes ia , ▁or ▁when ▁a ▁family ▁member ▁develop s ▁the ▁sympt oms . ▁There ▁is ▁no ▁simple , ▁straightforward ▁test ▁to ▁diagn ose ▁the ▁condition . ▁When ▁M H ▁develop s ▁during ▁a ▁procedure , ▁treatment ▁with ▁d ant rol ene ▁sod ium ▁is ▁usually ▁initi ated ; ▁d ant rol ene ▁and ▁the ▁avoid ance ▁of ▁su x am eth on ium ▁administration ▁in ▁sus cept ible ▁people ▁have ▁marked ly ▁reduced ▁the ▁mort ality ▁from ▁this ▁condition . ▁ ▁Ap nea ▁ ▁The ▁normal ▁short ▁duration ▁of ▁action ▁of ▁su x am eth on ium ▁is ▁due ▁to ▁the ▁rapid ▁met abol ism ▁of ▁the ▁drug ▁by ▁non - specific ▁pl asma ▁ch olin ester ases . ▁However ▁pl asma ▁ch olin ester ase ▁activity ▁is ▁reduced ▁in ▁some ▁people ▁due ▁to ▁either ▁gen etic ▁variation ▁or ▁acquired ▁conditions , ▁which ▁results ▁in ▁a ▁prolong ed ▁duration ▁of ▁neur om us cular ▁block . ▁Gen et ically , ▁nin ety ▁six ▁percent ▁of ▁the ▁population ▁have ▁a ▁normal ▁( E u : E u ) ▁gen ot ype ▁and ▁block ▁duration ; ▁however , ▁some ▁people ▁have ▁at yp ical ▁gen es ▁( E a , ▁Es , ▁E f ) ▁which ▁can ▁be ▁found ▁in ▁varying ▁combinations ▁with