. ▁▁ ▁Some ▁dis adv antages ▁to ▁the ▁use ▁of ▁b acter i oph ages ▁also ▁exist , ▁however . ▁B acter i oph ages ▁may ▁har bour ▁vir ul ence ▁factors ▁or ▁to xic ▁gen es ▁in ▁their ▁genom es ▁and , ▁prior ▁to ▁use , ▁it ▁may ▁be ▁pr udent ▁to ▁identify ▁gen es ▁with ▁similarity ▁to ▁known ▁vir ul ence ▁factors ▁or ▁to x ins ▁by ▁genom ic ▁sequ encing . ▁In ▁addition , ▁the ▁or al ▁and ▁IV ▁administration ▁of ▁ph ages ▁for ▁the ▁er adic ation ▁of ▁b acter ial ▁in fe ctions ▁pos es ▁a ▁much ▁higher ▁safety ▁risk ▁than ▁top ical ▁application . ▁Also , ▁there ▁is ▁the ▁additional ▁concern ▁of ▁uncertain ▁imm une ▁responses ▁to ▁these ▁large ▁ant igen ic ▁co ck t ails . ▁▁ ▁There ▁are ▁considerable ▁regul atory ▁hur d les ▁that ▁must ▁be ▁cleared ▁for ▁such ▁ther ap ies . ▁Despite ▁numerous ▁challeng es , ▁the ▁use ▁of ▁b acter i oph ages ▁as ▁a ▁replacement ▁for ▁ant im icro b ial ▁agents ▁against ▁M DR ▁path og ens ▁that ▁no ▁longer ▁respond ▁to ▁conventional ▁ant ib iot ics , ▁remains ▁an ▁attract ive ▁option . ▁ ▁Ph y to chem ical s ▁Pl ants ▁are ▁an ▁important ▁source ▁of ▁ant im icro b ial ▁comp ounds ▁and ▁traditional ▁he al ers ▁have ▁long ▁used ▁plants ▁to ▁prevent ▁or ▁c ure ▁inf ect ious ▁dise ases . ▁There ▁is ▁a ▁recent ▁renew ed ▁interest ▁into ▁the ▁use ▁of ▁natural ▁products ▁for