▁surv ival ▁of ▁cancer ▁patients . ▁It ▁is ▁believed ▁that ▁Z EB 1 / 2 , ▁Sn ail , ▁and ▁Sl ug ▁are ▁induced ▁by ▁T G F - β , ▁infl am mat ory ▁cy tok ines , ▁and ▁hy po x ia . <0x09> ▁ <0x09> ▁Collect ive - amo eb oid ▁transition <0x09> ▁ <0x09> ▁Based ▁on ▁experimental ▁data , ▁a ▁number ▁of ▁research ers ▁indicate ▁the ▁possible ▁existence ▁of ▁a ▁so - called ▁collect ive - ▁am o eb oid ▁transition ▁( Fig . ▁ 1 ), ▁when ▁tum or ▁masses ▁inv ading ▁surrounding ▁t issues ▁in ▁the ▁form ▁of ▁collect ive ▁mult ic ell ular ▁groups ▁dis soci ate ▁into ▁single ▁migr ating ▁cells ▁that ▁use ▁the ▁am o eb oid ▁movement . ▁This ▁event ▁has ▁been ▁shown ▁to ▁become ▁possible ▁with ▁the ▁application ▁of ▁in hib itors ▁of ▁integr in ▁re cept ors ▁of ▁the ▁ β 1 ▁family , ▁since ▁these ▁mole cules ▁play ▁a ▁key ▁role ▁both ▁in ▁the ▁formation ▁of ▁cell - cell ▁contacts ▁and ▁in ▁the ▁interactions ▁between ▁tum or ▁cells ▁and ▁surrounding ▁t issue ▁components . <0x09> ▁ <0x09> ▁M esen ch ym al - ep ith el ial ▁transition <0x09> ▁ <0x09> ▁There ▁are ▁actually ▁no ▁studies ▁devoted ▁to ▁the ▁investigation ▁of ▁the ▁mechan isms ▁underlying ▁the ▁mes en ch ym al - ▁ep ith el ial ▁transition . ▁However , ▁the ▁possibility ▁of ▁such ▁a ▁phenomen on ▁is ▁recognized . ▁In ▁this ▁case , ▁it ▁is ▁said ▁that ▁often ,