▁ph osph at ase ▁ 2 ▁( PP 2 A ) ▁( Fig . ▁ 1 ). ▁Both ▁lead ▁to ▁the ▁release ▁of ▁C AR ▁from ▁the ▁multip rote in ▁complex ▁and ▁its ▁trans location ▁into ▁the ▁nucle us . ▁Here , ▁C AR ▁forms ▁a ▁heter od imer ▁with ▁ret ino id ▁X ▁re ceptor ▁( R X R ) ▁and ▁interact s ▁with ▁the ▁phen obar b ital - respons ive ▁en han cer ▁module ▁( P B RE M ), ▁a ▁dist al ▁en han cer ▁activ ating ▁trans cription ▁of ▁C AR ▁target ▁gen es . ▁▁ ▁The ▁cons ensus ▁sequence ▁of ▁P B RE M , ▁containing ▁direct ▁repeat - 4 ▁mot ifs , ▁was ▁found ▁to ▁be ▁conser ved ▁in ▁mouse , ▁rat ▁and ▁human ▁' C yp 2 b ' ▁gen es . ▁ ▁Direct ▁activation ▁▁▁ 1 , 4 - bis [ 2 -( 3 , 5 - d ich lor opy rid y lo xy )] ben z ene ▁( T CP OB OP ) ▁is ▁thought ▁to ▁bind ▁directly ▁to ▁mouse ▁C AR , ▁thus ▁indu cing ▁its ▁trans location ▁into ▁the ▁nucle us . ▁ ▁TCP OB OP ▁does ▁not ▁bind ▁to ▁human ▁C AR ▁and ▁hence ▁has ▁no ▁effect ▁on ▁it . ▁Human ▁C AR ▁can ▁be ▁activ ated ▁by ▁C IT CO ▁( 6 -( 4 - ch lor oph en yl ) im id az o ( 2 , 1 - b )( 1 , 3 ) th ia