▁system ic ▁ther apy ▁for ▁treatment ▁of ▁these ▁les ions . ▁ ▁Other ▁system ic ▁ther ap ies ▁which ▁may ▁be ▁effective ▁for ▁I H ▁treatment ▁include ▁v inc rist ine , ▁ ▁inter fer on , ▁and ▁other ▁agents ▁with ▁anti ang i ogen ic ▁properties . ▁ ▁V inc rist ine , ▁which ▁requires ▁central ▁ven ous ▁access ▁for ▁administration , ▁is ▁tradition ally ▁used ▁as ▁a ▁chem other apy ▁agent , ▁but ▁has ▁been ▁demonstrated ▁to ▁have ▁effic acy ▁against ▁hem ang iom as ▁and ▁other ▁child hood ▁v asc ular ▁tum ors , ▁such ▁as ▁kap os iform ▁hem ang io end oth eli oma ▁and ▁tu ft ed ▁ang i oma . ▁Inter fer on - alpha ▁ 2 a ▁and ▁ 2 b , ▁given ▁by ▁sub cut aneous ▁injection , ▁has ▁shown ▁effic acy ▁against ▁hem ang iom as , ▁but ▁may ▁result ▁in ▁sp astic ▁di ple gia ▁in ▁up ▁to ▁ 2 0 % ▁of ▁treated ▁children . ▁ ▁These ▁agents ▁are ▁rarely ▁used ▁now ▁in ▁the ▁era ▁of ▁beta - block er ▁ther apy . ▁ ▁In tr ales ional ▁cort ic ost ero id ▁( us ually ▁tri am cin ol one ) ▁injection ▁has ▁been ▁used ▁for ▁small , ▁local ized ▁hem ang iom as , ▁where ▁it ▁has ▁been ▁demonstrated ▁to ▁be ▁relatively ▁safe ▁and ▁effective . ▁ ▁In jection ▁of ▁upper ▁e y el id ▁hem ang iom as ▁is ▁controvers ial , ▁given ▁the ▁reported ▁risk ▁of ▁ret