yd rate ▁sul f otr ans fer ases ▁are ▁transm emb rane ▁en zym es ▁in ▁the ▁Gol gi ▁that ▁modify ▁car bo h yd r ates ▁on ▁g ly col ip ids ▁or ▁g ly op rote ins ▁as ▁they ▁move ▁along ▁the ▁secret ory ▁path way . ▁They ▁have ▁a ▁short ▁cy top las mic ▁N - term inal , ▁one ▁transm emb rane ▁domain , ▁and ▁a ▁large ▁C - term inal ▁Gol gi ▁lum inal ▁domain . ▁They ▁are ▁distinct ▁from ▁c yt os ol ic ▁sul f otr ans fer ases ▁in ▁both ▁structure ▁and ▁function . ▁While ▁c yt os ol ic ▁sul f otr ans fer ases ▁play ▁a ▁met abol ic ▁role ▁by ▁modifying ▁small ▁mole c ule ▁substr ates ▁such ▁as ▁ster oid s , ▁flav ono ids , ▁ne uro trans mit ters , ▁and ▁phen ols , ▁car bo h yd rate ▁sul f otr ans fer ases ▁have ▁a ▁fundamental ▁role ▁in ▁ext rac ell ular ▁sign alling ▁and ▁ad hes ion ▁by ▁generating ▁unique ▁lig ands ▁through ▁the ▁modification ▁of ▁car bo h yd rate ▁sc aff olds . ▁Since ▁the ▁substr ates ▁of ▁car bo h yd rate ▁sul f otr ans fer ases ▁are ▁larger , ▁they ▁have ▁larger ▁active ▁sites ▁than ▁c yt os ol ic ▁sul f otr ans fer ases . ▁ ▁There ▁are ▁two ▁major ▁families ▁of ▁car bo h yd rate ▁sul f otr ans fer ases : ▁he par an ▁sul f