▁her it ability ▁of ▁coron ary ▁ar tery ▁disease ▁has ▁been ▁estimated ▁between ▁ 4 0 % ▁and ▁ 6 0 %. ▁Gen ome - wide ▁association ▁studies ▁have ▁identified ▁over ▁ 1 6 0 ▁gen etic ▁sus cept ibility ▁lo ci ▁for ▁coron ary ▁ar tery ▁disease . ▁ ▁Other ▁ ▁End omet rios is ▁in ▁women ▁under ▁the ▁age ▁of ▁ 4 0 . ▁De pression ▁and ▁host ility ▁appear ▁to ▁be ▁ris ks . ▁ ▁The ▁number ▁of ▁categories ▁of ▁ad verse ▁child hood ▁experiences ▁( ps ych ological , ▁physical , ▁or ▁sexual ▁ab use ; ▁violence ▁against ▁mother ; ▁or ▁living ▁with ▁household ▁members ▁who ▁were ▁subst ance ▁ab users , ▁ment ally ▁ill , ▁suic idal , ▁or ▁in car cer ated ) ▁showed ▁a ▁grad ed ▁correlation ▁with ▁the ▁presence ▁of ▁adult ▁dise ases ▁including ▁coron ary ▁ar tery ▁( isch em ic ▁heart ) ▁disease . ▁▁ ▁Hem ost atic ▁factors : ▁High ▁levels ▁of ▁f ibr in ogen ▁and ▁co ag ulation ▁factor ▁VII ▁are ▁associated ▁with ▁an ▁increased ▁risk ▁of ▁C AD . ▁▁ ▁Low ▁hem og lo bin . ▁ ▁In ▁the ▁Asian ▁population , ▁the ▁b ▁f ibr in ogen ▁gene ▁G - 4 5 5 A ▁polym orphism ▁was ▁associated ▁with ▁the ▁risk ▁of ▁C AD . ▁ ▁Path oph ys i ology ▁ ▁Lim itation ▁of ▁blood ▁flow ▁to ▁the ▁heart ▁causes ▁is chem ia ▁( cell ▁star v ation ▁secondary ▁to ▁a ▁lack ▁of ▁o xygen ) ▁of