z ole - 5 - car bal de hy de ▁O -( 3 , 4 - d ich lor oben zy l ) ox ime ). ▁ ▁Ind irect ▁activation ▁▁ ▁Ph en obar b ital ▁( P B ), ▁a ▁widely ▁used ▁ant icon v uls ant , ▁is ▁used ▁as ▁a ▁model ▁lig and ▁for ▁indirect ▁C AR ▁activation . ▁ ▁P B ▁activ ates ▁C AR , ▁by ▁indu cing ▁the ▁de ph osph ory lation ▁of ▁C AR ▁through ▁P P 2 A . ▁How ▁P P 2 A ▁is ▁activ ated ▁remains ▁unclear , ▁but ▁several ▁different ▁mechan isms ▁have ▁been ▁proposed . ▁ ▁The ▁rec ruit ment ▁of ▁P P 2 A ▁has ▁been ▁shown ▁to ▁be ▁medi ated ▁by ▁the ▁multip rote in ▁complex . ▁As ▁P B ▁is ▁involved ▁in ▁the ▁activation ▁of ▁A MP - activ ated ▁protein ▁kin ase , ▁it ▁has ▁been ▁suggested ▁that ▁A MP K ▁activ ates ▁P P 2 A . ▁▁ ▁Alternatively , ▁P P 2 A ▁might ▁be ▁activ ated ▁through ▁another ▁path way ▁including ▁the ▁e pid erm al ▁growth ▁factor ▁re ceptor ▁( EG FR ) ▁and ▁the ▁re ceptor ▁for ▁activ ated ▁C ▁kin ase ▁ 1 ▁( R ACK 1 ). ▁In ▁the ▁absence ▁of ▁P B , ▁the ▁e pid erm al ▁growth ▁factor ▁( EG F ) ▁bind s ▁to ▁E G FR , ▁thereby ▁activ ating ▁the ▁ster oid ▁re ceptor ▁co activ ator - 1 ▁( S rc 1