ary ▁relationship ▁between ▁r R NA ▁and ▁the ▁Sh ine - D al gar no ▁sequence ▁in ▁m R NA , ▁ ▁it ▁was ▁proposed ▁that ▁the ▁sequence ▁at ▁the ▁ 3 '- end ▁of ▁the ▁r R NA ▁determ ines ▁the ▁capacity ▁of ▁the ▁pro k ary otic ▁rib os ome ▁to ▁translate ▁a ▁particular ▁gene ▁in ▁an ▁m R NA . ▁Base ▁pair ing ▁between ▁the ▁ 3 '- end ▁of ▁the ▁r R NA ▁and ▁the ▁Sh ine - D al gar no ▁sequence ▁in ▁m R NA ▁is ▁a ▁mechanism ▁by ▁which ▁the ▁cell ▁can ▁distinguish ▁between ▁initi ator ▁A UG s ▁and ▁internal ▁and / or ▁out - of - frame ▁A UG ▁sequences . ▁The ▁degree ▁of ▁base ▁pair ing ▁also ▁plays ▁a ▁role ▁in ▁determ ining ▁the ▁rate ▁of ▁init iation ▁at ▁different ▁A UG ▁initi ator ▁cod ons . ▁ ▁Trans lation ▁term ination ▁In ▁ 1 9 7 3 ▁Dal gar no ▁and ▁Sh ine ▁proposed ▁that ▁in ▁e uk ary otes , ▁the ▁ 3 '- end ▁of ▁the ▁small ▁ 1 8 S ▁r R NA ▁may ▁play ▁a ▁role ▁in ▁the ▁term ination ▁of ▁protein ▁synth esis ▁by ▁complement ary ▁base ▁pair ing ▁with ▁term ination ▁cod ons . ▁This ▁came ▁from ▁their ▁observation ▁that ▁the ▁ 3 ' ▁terminal ▁sequences ▁of ▁ 1 8 S ▁r R NA ▁from ▁D ros oph ila ▁mel an og aster , ▁Sac char omy ces ▁c ere vis iae , ▁and ▁rabb it