▁of ▁AB CC 1 ▁was ▁found ▁to ▁increase ▁with ▁the ▁stage ▁of ▁the ▁disease ▁while ▁allowing ▁resistance ▁to ▁chem other ape ut ic ▁dru gs . ▁ ▁Animal ▁studies ▁ ▁Because ▁of ▁its ▁significant ▁role ▁in ▁the ▁transport ation ▁of ▁organ ic ▁an ion ▁mole cules ▁and ▁recent ▁association ▁with ▁multiple ▁ill ness es ▁including ▁Al z heimer ' s ▁disease ▁( AD ), ▁the ▁AB CC 1 ▁protein ▁has ▁become ▁a ▁potential ▁drug ▁target . ▁ ▁In ▁AB BC 1 ▁knock out ▁m ice , ▁▁ β - amy lo id ▁clear ance ▁is ▁much ▁lower ▁than ▁in ▁wild - type ▁m ice ▁that ▁expressed ▁the ▁gene . ▁Furthermore , ▁in ▁mouse ▁models ▁of ▁AD , ▁treatment ▁with ▁th i eth yl per azine , ▁a ▁drug ▁that ▁activ ates ▁AB BC 1 , ▁increases ▁ β - amy lo id ▁clear ance ▁and ▁decre ases ▁in ▁the ▁amount ▁of ▁ β - amy lo id ▁found ▁in ▁the ▁bra ins . ▁ ▁St . ▁John ' s ▁w ort , ▁a ▁subst ance ▁containing ▁the ▁chemical ▁hyper for in , ▁has ▁also ▁been ▁shown ▁to ▁have ▁a ▁positive ▁effect ▁on ▁activity ▁levels ▁of ▁AB CC 1 . ▁In ▁a ▁study ▁of ▁the ▁effects ▁of ▁St . ▁John ' s ▁w ort ▁on ▁AP P - t g ▁m ice , ▁an ▁extract ▁of ▁St . ▁John ' s ▁w ort ▁that ▁contained ▁decre ased ▁levels ▁of ▁hyper for in ▁increased ▁the ▁activity ▁of ▁AB CC 1 ▁by ▁ 7 0 ▁percent