▁these ▁patients ▁we ▁can ▁also ▁find ▁vir al ▁in fe ctions ▁caused ▁mostly ▁by ▁Her pes vir idae , ▁that ▁also ▁affect ▁the ▁skin . ▁The ▁my c ob acter ial ▁in fe ctions ▁are ▁often ▁caused ▁by ▁My c ob acter ium ▁t uber cul osis ▁or ▁environmental ▁b acter ia . ▁Very ▁common ▁are ▁also ▁auto imm une ▁sympt oms ▁like ▁type ▁ 1 ▁di ab etes , ▁c yt open ia , ▁regression ▁of ▁the ▁th ym us ▁or ▁system ic ▁l up us ▁er yth em atos us . ▁When ▁T - cell ▁def ic ient , ▁these ▁auto imm une ▁dí se ases ▁are ▁very ▁common . ▁C MC ▁was ▁also ▁reported ▁as ▁a ▁common ▁sympt om ▁in ▁patients ▁with ▁hyper ▁imm un og lob ul in ▁E ▁synd rome ▁( hyper - Ig E ) ▁and ▁with ▁auto imm une ▁poly end ocr ine ▁synd rome ▁type ▁I . ▁There ▁was ▁reported ▁an ▁inter le uk in ▁ 1 7 A ▁role , ▁because ▁of ▁low ▁levels ▁of ▁IL - 1 7 A ▁producing ▁T - cell s ▁in ▁C MC ▁patients . ▁ ▁With ▁various ▁genom ic ▁and ▁gen etic ▁methods ▁was ▁discovered , ▁that ▁a ▁heter o zy g ous ▁gain ▁of ▁function ▁mut ation ▁of ▁ST AT 1 ▁is ▁a ▁cause ▁of ▁more ▁than ▁a ▁half ▁C MC ▁cases . ▁This ▁mut ation ▁is ▁caused ▁by ▁defect ▁in ▁the ▁co iled - co il ▁domain , ▁domain ▁that ▁bind s ▁DNA , ▁N -