ie ▁( Jack ie ▁Guerra ), ▁a ▁Y ale ▁University ▁gradu ate ▁who ▁now ▁has ▁a ▁tr end y ▁hair ▁sal on ▁in ▁Los ▁Angeles , ▁California , ▁att ends ▁law - school ▁classes ▁at ▁night , ▁and ▁long s ▁to ▁find ▁a ▁man . ▁She ▁shares ▁an ▁a partment ▁with ▁her ▁friends ▁Domin ique ▁( Le ah ▁Rem ini ), ▁a ▁c yn ical ▁assistant ▁at ▁Vent ura ▁Records , ▁and ▁Susan ▁( M ia ▁C ott et ), ▁who ' s ▁about ▁to ▁get ▁her ▁psych other ap ist ▁license ▁and ▁is ▁ne uro t ic ▁herself . ▁She ' s ▁good ▁friends ▁with ▁her ▁co - work ers ▁at ▁the ▁sal on , ▁Rosa ▁( T racy ▁V ilar ) ▁and ▁Fred dy ▁( Har ry ▁Van ▁G ork um ), ▁an ▁ob no x ious , ▁woman izing ▁English ▁ha irst y list . ▁R ounding ▁out ▁the ▁cast ▁are ▁Mad eline ▁( R ox anne ▁Beck ford ), ▁a ▁y upp ie ▁executive ▁who ▁lives ▁across ▁the ▁hall , ▁and ▁Nathan ▁( C ra ig ▁Anton ), ▁Jack ie ' s ▁kl ut zy , ▁sex - obs essed ▁child hood ▁friend . ▁ ▁The ▁W B ▁network ▁called ▁Jack ie , ▁" the ▁first ▁Lat ina ▁to ▁star ▁in ▁her ▁own ▁series ". ▁ ▁Cast ▁ ▁Jack ie ▁Guerra ▁– ▁Jack ie ▁ ▁Le ah ▁Rem ini ▁– ▁Domin ique ▁Const ell ano ▁ ▁T racy ▁V ilar ▁– ▁Rosa ▁ ▁Ro x anne ▁Beck ford ▁–