▁sample , ▁und il uted ▁with ▁any ▁sol vent . ▁▁ ▁A ▁similarly ▁high ▁value ▁of ▁+ 1 6 ° ▁for ▁the ▁[ α ] D ▁of ▁" con i ine " ▁is ▁given , ▁without ▁explicit ▁c itation ▁of ▁the ▁source , ▁in ▁The ▁Mer ck ▁Index . ▁ ▁The ▁value ▁of ▁+ 7 . 7 ° ▁( c ▁= ▁ 4 . 0 , ▁CH Cl 3 ) ▁for ▁synth etic ▁S -( + )- con i ine ▁and ▁- 7 . 9 ° ▁( c ▁= ▁ 0 . 5 , ▁CH Cl 3 ) ▁for ▁synth etic ▁R -( − )- con i ine ▁is ▁given ▁by ▁other ▁chem ists . ▁ ▁Sal ts ▁of ▁given ▁en anti om ers ▁do ▁not ▁necessarily ▁have ▁the ▁same ▁specific ▁rotation ▁as ▁the ▁same ▁en anti omer ▁of ▁the ▁free ▁base . ▁The ▁hydro ch lor ide ▁sal ts ▁of ▁the ▁( S )- ( +) ▁and ▁( R )- ( − ) ▁en anti om ers ▁of ▁con i ine ▁have ▁values ▁of ▁[ α ] D ▁of ▁+ 4 . 6 ° ▁and ▁- 5 . 2 ° , ▁respectively ▁( c ▁= ▁ 0 . 5 , ▁in ▁m eth an ol ). ▁ ▁Syn thesis ▁ ▁Many ▁synth eses ▁of ▁con i ine ▁have ▁been ▁reported ▁over ▁the ▁last ▁ 5 0 ▁years ; ▁one ▁example ▁of ▁a ▁s tere ose lect ive ▁synth esis ▁is ▁that ▁of ▁End ers ▁and ▁T ie bes , ▁who ▁c ite