oph age al ▁s ph inct er ▁won ' t ▁open ; ▁loss ▁of ▁in hib itory ▁neur ons ), ▁meg ac ol on , ▁and ▁m ega ure ter , ▁respectively . ▁ ▁Ro le ▁in ▁C NS ▁dis orders ▁Because ▁the ▁E NS ▁is ▁known ▁as ▁the ▁" bra in ▁of ▁the ▁gut ", ▁due ▁to ▁its ▁similar ities ▁with ▁the ▁C NS , ▁research ers ▁have ▁been ▁using ▁colon ic ▁bi ops ies ▁of ▁Park inson ' s ▁patients ▁to ▁help ▁better ▁understand ▁and ▁manage ▁Park inson ' s ▁disease . ▁P D ▁patients ▁are ▁known ▁to ▁experience ▁severe ▁const ip ation ▁due ▁to ▁G I ▁tract ▁d ys function ▁years ▁before ▁the ▁on set ▁of ▁motor ▁movement ▁comp lications , ▁which ▁character ises ▁Park inson ' s ▁disease . ▁ ▁History ▁Leopold ▁A uer bach , ▁a ▁ne urop ath ologist , ▁was ▁one ▁of ▁the ▁first ▁to ▁further ▁research ▁the ▁nerv ous ▁system ▁using ▁hist ological ▁st aining ▁methods . ▁ ▁References ▁ ▁External ▁links ▁ ▁S lide ▁at ▁u cla . edu ▁▁▁▁▁▁▁ ▁Category : Dig est ive ▁system ▁Category : Enter ic ▁nerv ous ▁system ▁Category : N erve ▁p lex us <0x0A> </s> ▁This ▁is ▁a ▁list ▁of ▁all ▁companies ▁that ▁manufact ure ▁Rub ik ' s ▁Cub es ▁and ▁other ▁similar ▁tw ist y ▁puzz les . ▁ ▁Rub ik ' s ▁brand ▁( original ) ▁ ▁M ef fert ’ s ▁ ▁O sk ar ▁ ▁Wit E den ▁produced ▁by ▁Gu ang