ulation . ▁Gu an ▁has ▁made ▁sem inal ▁contributions ▁in ▁the ▁fields ▁of ▁protein ▁ty ros ine ▁ph osph at ase , ▁Mit ogen - Activ ated ▁Prote in ▁( MAP ) ▁kin ase , ▁and ▁the ▁m amm al ian ▁Target ▁of ▁Rap am yc in ▁( m T OR ) ▁path ways . ▁Gu an ▁and ▁his ▁team ▁have ▁published ▁numerous ▁influ ential ▁papers ▁in , ▁many ▁publications , ▁such ▁as ▁Cell , ▁Nature ▁and ▁Science . ▁ ▁Research ▁in ▁Gu an ' s ▁labor atory ▁focus es ▁on ▁int rac ell ular ▁signal ▁trans du ction ▁in ▁cell ▁growth ▁reg ulation ▁and ▁cancer ▁bi ology . ▁ ▁T uber ous ▁s cl eros is ▁complex ▁( T SC ) ▁is ▁an ▁aut os om al ▁dominant ▁dis order ▁character ized ▁by ▁the ▁development ▁of ▁ben ign ▁tum ors ▁in ▁a ▁wide ▁range ▁of ▁t issues . ▁Mut ations ▁in ▁either ▁the ▁T SC 1 ▁or ▁T SC 2 ▁tum or ▁suppress or ▁gene ▁are ▁responsible ▁for ▁T SC ▁disease . ▁T SC 1 ▁and ▁T SC 2 ▁prote ins ▁form ▁a ▁physical ▁and ▁functional ▁complex . ▁ ▁Rec ent ▁studies ▁from ▁Gu an ' s ▁labor atory ▁demonstrate ▁that ▁T SC 1 / T SC 2 ▁functions ▁to ▁in hib it ▁the ▁m amm al ian ▁target ▁of ▁rap am yc in ▁( m T OR ), ▁which ▁is ▁a ▁central ▁cell ▁growth ▁controller ▁conser ved ▁from ▁ye ast ▁to ▁human . ▁m T OR ▁integr ates ▁a ▁wide ▁range