▁in ▁m ood ▁and ▁self - este em . ▁ ▁Reg ular ▁aer ob ic ▁exercise ▁impro ves ▁sympt oms ▁associated ▁with ▁a ▁variety ▁of ▁central ▁nerv ous ▁system ▁dis orders ▁and ▁may ▁be ▁used ▁as ▁an ▁adj unct ▁ther apy ▁for ▁these ▁dis orders . ▁ ▁There ▁is ▁clear ▁evidence ▁of ▁exercise ▁treatment ▁effic acy ▁for ▁major ▁de press ive ▁dis order ▁and ▁attention ▁def ic it ▁hyper activity ▁dis order . ▁The ▁American ▁Academy ▁of ▁Ne uro log y ' s ▁clin ical ▁practice ▁guid eline ▁for ▁m ild ▁cogn itive ▁imp air ment ▁indicates ▁that ▁clin icians ▁should ▁recommend ▁regular ▁exercise ▁( two ▁times ▁per ▁week ) ▁to ▁individuals ▁who ▁have ▁been ▁diagn osed ▁with ▁this ▁condition . ▁Re views ▁of ▁clin ical ▁evidence ▁also ▁support ▁the ▁use ▁of ▁exercise ▁as ▁an ▁adj unct ▁ther apy ▁for ▁certain ▁ne uro de gener ative ▁dis orders , ▁particularly ▁Al z heimer ’ s ▁disease ▁and ▁Park inson ' s ▁disease . ▁Reg ular ▁exercise ▁is ▁also ▁associated ▁with ▁a ▁lower ▁risk ▁of ▁developing ▁ne uro de gener ative ▁dis orders . ▁A ▁large ▁body ▁of ▁pre cl in ical ▁evidence ▁and ▁emer ging ▁clin ical ▁evidence ▁supports ▁the ▁use ▁of ▁exercise ▁as ▁an ▁adj unct ▁ther apy ▁for ▁the ▁treatment ▁and ▁prevent ion ▁of ▁drug ▁add ict ions . ▁Reg ular ▁exercise ▁has ▁also ▁been ▁proposed ▁as ▁an ▁adj unct ▁ther apy ▁for ▁brain ▁can cers . ▁ ▁Long - term ▁effects ▁ ▁Ne uro pl astic ity ▁Ne uro pl