select ive ▁mus car in ic ▁ac et yl ch oline ▁re ceptor ▁ag on ist ▁which ▁acts ▁as ▁a ▁full ▁ag on ist ▁at ▁the ▁M 1 ▁sub type , ▁and ▁as ▁a ▁partial ▁ag on ist ▁at ▁the ▁M 2 ▁and ▁M 3 ▁sub types . ▁It ▁was ▁under ▁development ▁for ▁the ▁treatment ▁of ▁Al z heimer ' s ▁disease ▁but ▁showed ▁only ▁mod est ▁or ▁poor ▁effic acy ▁in ▁r hes us ▁mon keys ▁and ▁humans , ▁respectively , ▁perhaps ▁due ▁to ▁an ▁array ▁of ▁do se - lim iting ▁side ▁effects ▁including ▁increased ▁heart ▁rate ▁and ▁blood ▁pressure , ▁increased ▁sal iv ation , ▁ur inary ▁frequency ▁and ▁burning ▁upon ▁ur ination , ▁increased ▁lac rim ation ▁and ▁nas al ▁secret ion , ▁ab normal ▁accommod ation , ▁heart burn , ▁ups et ▁st om ach ▁as ▁well ▁as ▁cr amps , ▁n ause a , ▁vom iting ▁and ▁di arr he a , ▁excess ive ▁swe ating ▁and ▁pal pit ations . ▁ ▁See ▁also ▁▁ ▁A ce cl id ine ▁ ▁V ed ac l id ine ▁ ▁References ▁▁ ▁Category : Mus car in ic ▁ag on ists ▁Category : Qu inu cl id ines ▁Category : Al ky ne ▁derivatives ▁Category : eth ers <0x0A> </s> ▁The ▁United ▁Nations ▁General ▁Assembly ▁designated ▁the ▁ 1 9 9 0 s ▁as ▁the ▁International ▁Dec ade ▁for ▁Natural ▁Dis aster ▁Red u ction ▁( ID ND R ). ▁ ▁Its ▁basic ▁objective ▁was ▁to ▁decrease ▁the ▁loss