▁a ▁slow ▁rate ▁of ▁cell ▁migration ▁is ▁observed . <0x09> ▁ <0x09> ▁Based ▁on ▁the ▁supp ression ▁of ▁the ▁expression ▁of ▁the ▁relevant ▁gen es ▁using ▁small ▁inter fer ing ▁R N As , ▁the ▁specific ▁activity ▁of ▁G TP ases ▁R ac 1 ▁and ▁C dc 4 2 ▁was ▁demonstrated ▁to ▁be ▁the ▁characteristic ▁feature ▁of ▁the ▁mes en ch ym al ▁type ▁of ▁invasion . ▁Supp ression ▁of ▁G TP ase ▁R ac 1 ▁through ▁signal ing ▁activation ▁of ▁G TP ase ▁R ho A ▁and ▁its ▁effect or , ▁RO CK ▁kin ase , ▁leads ▁to ▁block age ▁of ▁the ▁mes en ch ym al ▁migration ▁of ▁tum or ▁cells . <0x09> ▁ <0x09> ▁Am o eb oid ▁cell ▁migration <0x09> ▁ <0x09> ▁The ▁am o eb oid ▁mechanism ▁of ▁invas ive ▁growth ▁is ▁the ▁most ▁primitive ▁and , ▁at ▁the ▁same ▁time , ▁the ▁most ▁efficient ▁mode ▁of ▁migration ▁of ▁single ▁tum or ▁cells . ▁In ▁all ▁of ▁its ▁features , ▁it ▁is ▁similar ▁to ▁the ▁behavior ▁and ▁movement ▁of ▁a ▁single - cel led ▁organ ism , ▁such ▁as ▁the ▁am o eb a ▁D ict y ost el ium ▁disco ide um . <0x09> ▁ <0x09> ▁The ▁use ▁of ▁ant ib od ies ▁that ▁block ▁integr ins ▁or ▁prote ase ▁in hib itors ▁in ▁clin ical ▁tri als ▁leads ▁to ▁the ▁emer gence ▁of ▁tum or ▁cells ▁with ▁the ▁am o eb oid ▁type ▁of ▁migration . ▁Similar ▁results ▁were ▁obtained ▁in ▁studies ▁of ▁m align ant