▁the ▁an ionic ▁ch lor ide ▁ ions . ▁Ch lor ide ▁ion ▁channels ▁are ▁p ore - form ing ▁memb rane ▁prote ins ▁that ▁allow ▁the ▁pass ive ▁transport ▁of ▁ch lor ide ▁ ions ▁across ▁bi ological ▁memb ran es . ▁Ch lor ide ▁ion ▁channels ▁involve ▁both ▁voltage - g ated ▁and ▁lig and - g ated ▁mechan isms ▁to ▁transport ▁the ▁ ions ▁across ▁cell ular ▁memb ran es . ▁Ch lor ide ▁ion ▁channels ▁have ▁been ▁found ▁to ▁play ▁cru cial ▁roles ▁in ▁the ▁development ▁of ▁human ▁dise ases , ▁for ▁example , ▁mut ations ▁in ▁the ▁gen es ▁encoding ▁ch lor ide ▁ion ▁channels ▁lead ▁to ▁a ▁variety ▁of ▁de le ter ious ▁dise ases ▁in ▁mus cle , ▁kid ney , ▁b one , ▁and ▁brain , ▁including ▁c yst ic ▁fib ros is , ▁o ste op or osis , ▁and ▁ep ile ps y , ▁and ▁similarly ▁their ▁activation ▁is ▁supposed ▁to ▁be ▁responsible ▁for ▁the ▁pro gression ▁of ▁gli oma ▁in ▁the ▁brain ▁and ▁the ▁growth ▁of ▁mal aria - par as ite ▁in ▁the ▁red ▁blood ▁cells . ▁Currently , ▁ch lor ide ▁ion ▁channels ▁are ▁not ▁completely ▁understood , ▁and ▁more ▁research ▁is ▁necessary . ▁ ▁See ▁also ▁▁ ▁Cal ci um ▁in ▁bi ology ▁ ▁Mag nes ium ▁in ▁bi ology ▁ ▁References ▁ ▁Category : I ons ▁Category : Cell ▁bi ology ▁Category : Sign al ▁trans du ction <0x0A> </s> ▁Lake ▁Zahl ▁National ▁Wild life ▁Ref uge ▁is