▁the ▁Perry ▁Ex ped ition ▁and ▁with ▁the ▁increased ▁threat ▁to ▁Japanese ▁so vere ig nt y ▁pos ed ▁by ▁the ▁European ▁powers ▁and ▁their ▁Black ▁ships , ▁the ▁Japanese ▁government ▁turned ▁towards ▁the ▁Dutch ▁for ▁technical ▁and ▁military ▁assistance . ▁The ▁Nag as aki ▁Naval ▁Training ▁Center ▁was ▁opened ▁in ▁ 1 8 5 5 ▁with ▁Dutch ▁military ▁advis ors ▁to ▁teach ▁the ▁Japanese ▁about ▁steam ▁war ship ▁technology . ▁On ▁arrival , ▁he ▁found ▁that ▁his ▁prede cess or ▁Jan ▁K arel ▁van ▁den ▁Bro ek ▁had ▁been ▁dev oting ▁much ▁of ▁his ▁energ ies ▁into ▁production ▁of ▁a ▁Japanese - D utch / D utch - J apan ese ▁dictionary , ▁and ▁acting ▁as ▁technical ▁ad visor ▁on ▁a ▁wide ▁range ▁of ▁engineering ▁and ▁technical ▁questions , ▁rather ▁than ▁concentr ating ▁on ▁medicine ▁or ▁medical ▁education . ▁However , ▁this ▁provided ▁Pom pe ▁van ▁Me er der vo ort ▁with ▁a ▁foundation ▁on ▁which ▁he ▁was ▁able ▁to ▁establish ▁a ▁school ▁of ▁western ▁medicine ▁on ▁ 1 2 ▁November ▁ 1 8 5 7 . ▁Initial ly , ▁he ▁had ▁only ▁twelve ▁students ▁and ▁used ▁the ▁residence ▁of ▁Tak ash ima ▁Sh ū han ▁to ▁lecture ▁on ▁bi ology , ▁chem istry , ▁human ▁an atom y , ▁phys i ology , ▁and ▁path ology . ▁He ▁performed ▁the ▁first ▁recorded ▁human ▁aut ops y ▁in ▁Japan , ▁and ▁his ▁student ▁base ▁quickly ▁expanded ▁to ▁over ▁ 1 3 3 ▁students , ▁including ▁K us um oto ▁I ne ,