▁begin ▁Human ▁clin ical ▁studies ▁of ▁A pat in ib ▁in ▁Ph ase ▁II . ▁ ▁Non - cl in ical ▁studies ▁Some ▁cancer ▁cells ▁have ▁the ▁ability ▁to ▁develop ▁resistance ▁to ▁the ▁c yt ot ox ic ▁effects ▁of ▁certain ▁cancer ▁dru gs ▁( called ▁mult id rug ▁resistance ). ▁ ▁A ▁study ▁concluded ▁that ▁ap atin ib ▁may ▁be ▁useful ▁in ▁circum vent ing ▁cancer ▁cells ' ▁mult id rug ▁resistance ▁to ▁certain ▁conventional ▁ant ine op last ic ▁dru gs . ▁ ▁The ▁study ▁showed ▁that ▁ap atin ib ▁revers es ▁the ▁ABC B 1 - ▁and ▁ABC G 2 - medi ated ▁mult id rug ▁resistance ▁by ▁in hib iting ▁those ▁functions ▁and ▁increasing ▁the ▁int rac ell ular ▁concentr ations ▁of ▁the ▁ant ine op last ic ▁dru gs . ▁ ▁This ▁study ▁suggests ▁that ▁ap atin ib ▁will ▁be ▁potentially ▁effective ▁in ▁combination ▁ther ap ies ▁with ▁conventional ▁ant ican cer ▁dru gs ▁especially ▁in ▁cases ▁where ▁resistance ▁to ▁chem other apy ▁exists . ▁ ▁References ▁ ▁Category : Ty ros ine ▁kin ase ▁in hib itors ▁Category : Ex perimental ▁cancer ▁dru gs ▁Category : C yc lop ent anes <0x0A> </s> ▁The ▁United ▁Work ers ' ▁Party ▁is ▁a ▁cent rist ▁political ▁party ▁in ▁Domin ica . ▁ ▁As ▁of ▁the ▁ 2 0 1 9 ▁general ▁election , ▁it ▁is ▁the ▁only ▁opposition ▁party ▁represented ▁in ▁the ▁House ▁of ▁Assembly ▁of ▁Domin ica , ▁holding ▁three ▁of ▁the ▁twenty - one ▁seats . ▁