▁ox id ative ▁stress ▁protection , ▁as ▁observed ▁by ▁decre ased ▁GP X 1 ▁levels , ▁and ▁decre ased ▁tel omer ase ▁expression ▁may ▁help ▁give ▁rise ▁to ▁tel om ere ▁short ening ▁in ▁patients ▁suffering ▁from ▁M DD . ▁ ▁Inter actions ▁▁ ▁GP X 1 ▁has ▁been ▁shown ▁to ▁interact ▁with ▁A BL ▁and ▁G SH . ▁ ▁A ▁recently ▁discovered ▁suppress or ▁for ▁GP X 1 ▁is ▁S - aden os yl hom oc yst e ine , ▁which ▁when ▁accum ulated ▁in ▁end oth el ial ▁cells ▁can ▁cause ▁t R NA ( Sec ) ▁hyp om eth yl ation , ▁reducing ▁the ▁expression ▁of ▁GP X 1 ▁and ▁other ▁s elen op rote ins . ▁The ▁decre ased ▁GP X - 1 ▁expression ▁can ▁then ▁lead ▁to ▁infl am mat ory ▁activ ating ▁of ▁end oth el ial ▁cells , ▁helping ▁give ▁rise ▁to ▁a ▁pro ather ogen ic ▁end oth el ial ▁phen ot ype . ▁ ▁References ▁ ▁Further ▁reading ▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁ ▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁ ▁▁▁▁▁▁▁▁▁ ▁Category : EC ▁ 1 . 1 1 . 1 ▁Category : S elen op rote ins <0x0A> </s> ▁Ch ester ▁Road ▁can ▁mean : ▁Part ▁of ▁the ▁A 1 8 3 ▁road ▁from ▁South ▁Sh ield s ▁to ▁Ch ester - le - St reet ▁The ▁A 4 5 2 ▁road ▁in ▁England . ▁It ▁runs ▁from ▁Le am ington ▁Sp a , ▁War wick shire ▁to ▁Brown h ills ▁in ▁Staff ord shire , ▁following ▁the ▁line ▁of ▁the ▁ancient ▁dro