▁fat ty ▁ac ids ▁daily , ▁containing ▁ 4 6 0   m g ▁of ▁E - E PA ▁and ▁ 3 8 0   m g ▁of ▁E - D HA ▁( eth yl ▁est ers ), ▁may ▁lower ▁A po B 4 8 ▁in ▁hyper lip em ic ▁type ▁ 2 ▁di abet ics . ▁ ▁Inter actions ▁ ▁A po B ▁has ▁been ▁shown ▁to ▁interact ▁with ▁apo ( a ), ▁P PI B , ▁Cal cit on in ▁re ceptor ▁and ▁H SP 9 0 B 1 . ▁Inter action ▁of ▁A po B ▁with ▁prote og ly c ans , ▁col lagen , ▁and ▁fib ron ect in ▁is ▁believed ▁to ▁cause ▁a ther os cl eros is . ▁ ▁Inter active ▁path way ▁map ▁ ▁Reg ulation ▁The ▁expression ▁of ▁AP OB ▁is ▁reg ulated ▁by ▁c is - reg ul atory ▁elements ▁in ▁the ▁AP OB ▁ 5 ′ ▁U TR ▁and ▁ 3 ′ ▁U TR . ▁ ▁R NA ▁editing ▁The ▁m R NA ▁of ▁this ▁protein ▁is ▁subject ▁to ▁C yt id ine ▁to ▁U rid ine ▁( C ▁to ▁U ) ▁site - specific ▁R NA ▁editing . ▁A po B 1 0 0 ▁and ▁A po B 4 8 ▁are ▁encoded ▁by ▁the ▁same ▁gene , ▁however , ▁the ▁differences ▁in ▁the ▁translated ▁prote ins ▁are ▁not ▁due ▁to ▁alternative ▁sp lic ing ▁but ▁are ▁due ▁to ▁the ▁t issue - specific ▁R NA ▁editing ▁event . ▁A po B ▁m