▁each ▁sister ▁chrom at id ▁is ▁from ▁a ▁different ▁pole . ▁▁ 2 . ▁It ▁facil it ates ▁sp ind le ▁attachment ▁onto ▁chrom os om es . ▁▁ 3 . ▁It ▁facil it ates ▁DNA ▁repair ▁by ▁recom bin ation . ▁▁ 4 . ▁Rec ently ▁many ▁novel ▁functions ▁of ▁coh es in ▁have ▁been ▁discovered ▁in ▁many ▁different ▁cell ular ▁processes . ▁C oh es in ▁has ▁been ▁shown ▁to ▁be ▁responsible ▁for ▁trans cription ▁reg ulation , ▁DNA ▁double ▁str and ▁break ▁repair , ▁chrom os ome ▁cond ens ation , ▁pair ing ▁of ▁hom olog ous ▁chrom os om es ▁during ▁me ios is ▁I , ▁mon o - orientation ▁of ▁sister ▁k inet och ores ▁during ▁me ios is ▁I , ▁non - hom olog ous ▁cent rom ere ▁coupling , ▁chrom os ome ▁architecture ▁and ▁re arr ang ement , ▁DNA ▁rep lication ▁etc . ▁ ▁Dis soci ation ▁of ▁sister ▁chrom at id ▁coh es ion ▁ ▁The ▁an aph ase ▁prom oting ▁complex ▁associated ▁to ▁C dc 2 0 ▁( AP C / C - cd c 2 0 ) ▁marks ▁Sec ur in ▁( an aph ase ▁in hib itor ) ▁for ▁de grad ation ▁by ▁the ▁prote as ome . ▁Sec ur in ▁is ▁cle aved ▁at ▁an aph ase , ▁following ▁A PC / C - cd c 2 0 ▁medi ated ▁de grad ation , ▁and ▁it ▁rend ers ▁separ ase ▁( a ▁prote ase , ▁in hib ited ▁by ▁the