ition ▁a ▁clear ▁model ▁target ▁for ▁comb ating ▁di ab etic ▁ne urop ath y . ▁ ▁D rug ▁add iction ▁▁ ▁Sch iz op hren ia , ▁as ▁previously ▁described , ▁is ▁normally ▁mode led ▁in ▁the ▁labor atory ▁through ▁a ▁P CP ▁animal ▁model . ▁As ▁GC PI II ▁in hib ition ▁was ▁shown ▁to ▁possibly ▁limit ▁sch iz op hren ic ▁behavior ▁in ▁this ▁model , ▁this ▁suggests ▁that ▁GC PI II ▁in hib ition , ▁thus , ▁reduces ▁the ▁effect ▁of ▁P CP . ▁In ▁addition , ▁the ▁reward ▁action ▁of ▁many ▁dru gs ▁( c oca ine , ▁P CP , ▁alco hol , ▁nic ot ine , ▁etc .) ▁have ▁been ▁shown ▁with ▁increasing ▁evidence ▁to ▁be ▁related ▁to ▁gl ut am ate ▁levels , ▁on ▁which ▁N AA G ▁and ▁GC PI II ▁can ▁have ▁some ▁regul atory ▁effect . ▁ ▁In ▁summary , ▁the ▁find ings ▁of ▁multiple ▁drug ▁studies ▁to ▁conclude ▁that : ▁ ▁N AA G / NP ▁system ▁might ▁be ▁involved ▁in ▁neur onal ▁mechan isms ▁reg ulating ▁c ue - indu ced ▁c oca ine ▁cra ving , ▁the ▁development ▁of ▁c oca ine ▁se iz ure ▁kind ling , ▁and ▁management ▁of ▁op io id ▁add iction ▁and ▁alco hol ▁consum pt ive ▁behaviour . ▁Therefore , ▁N P ▁in hib itors ▁could ▁provide ▁a ▁novel ▁ther apy ▁for ▁such ▁conditions . ▁ ▁Other ▁dise ases ▁and ▁dis orders ▁▁ ▁N AA G ▁in hib ition ▁has ▁also ▁been ▁studied