▁human ▁breast ▁car cin oma ▁cells . ▁For ▁instance , ▁the ▁alle le ▁express ing ▁the ▁le uc ine - 1 9 8 ▁polym orphism ▁and ▁ 7 ▁al an ine ▁repe ats ▁generates ▁GP X - 1 ▁local ization ▁that ▁is ▁dis pro port ion ately ▁in ▁the ▁cy top las m ▁as ▁compared ▁to ▁other ▁alle lic ▁variants . ▁To ▁further ▁understand ▁the ▁effects ▁of ▁these ▁variants ▁on ▁GP X - 1 ▁function , ▁mut ant ▁GP X - 1 ▁with ▁mit och ond rial ▁local ization ▁sequences ▁were ▁generated ▁and ▁the ▁GP X - 1 ▁inf used ▁cells ▁were ▁analyz ed ▁for ▁their ▁response ▁to ▁ox id ative ▁stress , ▁energy ▁met abol ism ▁and ▁cancer - associ ated ▁signal ing ▁mole cules . ▁Ult imately , ▁GP X - 1 ▁variants ▁heavily ▁influenced ▁cell ular ▁bi ology , ▁suggesting ▁that ▁different ▁GP X - 1 ▁variants ▁affect ▁cancer ▁risk ▁differently . ▁ ▁An ▁analysis ▁of ▁GP X 1 ▁expression ▁in ▁o lig od end ro cy tes ▁from ▁patients ▁with ▁major ▁de press ive ▁dis order ▁and ▁control ▁patients ▁showed ▁that ▁GP X 1 ▁levels ▁were ▁significantly ▁decre ased ▁in ▁patients ▁with ▁the ▁dis order , ▁but ▁not ▁in ▁their ▁ast ro cy tes . ▁Short ening ▁of ▁tel om eres ▁and ▁decre ased ▁expression ▁of ▁tel omer ase ▁were ▁also ▁evident ▁in ▁these ▁o lig od end ro cy tes , ▁but ▁not ▁in ▁the ▁ast ro cy tes ▁in ▁these ▁patients . ▁This ▁suggests ▁that ▁decre ased