ize ▁ac etal de hy de ▁poor ly ▁and ▁are ▁thereby ▁sus cept ible ▁to ▁a ▁set ▁of ▁ad verse ▁responses ▁to ▁eth an ol ▁and ▁eth an ol - cont aining ▁be ver ages ; ▁these ▁responses ▁include ▁the ▁trans ient ▁accum ulation ▁of ▁ac etal de hy de ▁in ▁blood ▁and ▁t issues ; ▁fa cial ▁fl ushing ▁u rt ic aria , ▁system ic ▁der mat itis , ▁and ▁alco hol - indu ced ▁resp ir atory ▁re actions ▁( i . e . ▁rh init is ▁and , ▁primarily ▁in ▁patients ▁with ▁a ▁history ▁of ▁ast h ma , ▁m ild ▁to ▁moder ately ▁bron cho con str iction ▁ex ac erb ations ▁of ▁their ▁ast hm atic ▁disease . ▁ ▁These ▁all erg ic ▁reaction - like ▁sympt oms , ▁which ▁typically ▁occur ▁within ▁ 3 0 – 6 0 ▁minutes ▁of ▁ing est ing ▁alco hol ic ▁be ver ages , ▁do ▁not ▁appear ▁to ▁reflect ▁the ▁operation ▁of ▁classical ▁Ig E - ▁or ▁T ▁cell - related ▁aller gen - indu ced ▁re actions ▁but ▁rather ▁are ▁due , ▁at ▁least ▁in ▁large ▁part , ▁to ▁the ▁action ▁of ▁ac etal de hy de ▁in ▁stim ulating ▁t issue ▁m ast ▁cells ▁and ▁blood ▁bor ne ▁bas oph ils ▁to ▁release ▁hist am ine , ▁the ▁probable ▁ev oker ▁of ▁these ▁sympt oms . ▁▁▁▁ ▁The ▁percent ages ▁of ▁gl u 4 8 7 ly s ▁heter o zy g ous ▁plus ▁hom o zy g