▁pre gn ant ▁women ▁with ▁scr ub ▁ty ph us , ▁and ▁when ▁do xy cy cl ine ▁resistance ▁is ▁sus pected . ▁C ip ro f lo x ac in ▁cannot ▁be ▁used ▁safely ▁in ▁pre gn ancy ▁and ▁is ▁associated ▁with ▁still b irth s ▁and ▁mis car riage . ▁Com bin ation ▁ther apy ▁with ▁do xy cy cl ine ▁and ▁rif amp ic in ▁is ▁not ▁recommended ▁due ▁to ▁possible ▁ant agon ism . ▁ ▁V acc ine ▁ ▁No ▁lic ensed ▁v acc ines ▁are ▁available . ▁ ▁An ▁early ▁attempt ▁to ▁create ▁a ▁scr ub ▁ty ph us ▁v acc ine ▁occurred ▁in ▁the ▁United ▁Kingdom ▁in ▁ 1 9 3 7 ▁( with ▁the ▁Well come ▁Foundation ▁inf ect ing ▁around ▁ 3 0 0 , 0 0 0 ▁cot ton ▁r ats ▁ ▁in ▁a ▁class ified ▁project ▁called ▁" Operation ▁Ty burn "), ▁but ▁the ▁v acc ine ▁was ▁not ▁used . ▁ ▁The ▁first ▁known ▁batch ▁of ▁scr ub ▁ty ph us ▁v acc ine ▁actually ▁used ▁to ▁in oc ulate ▁human ▁subjects ▁was ▁dispatch ed ▁to ▁India ▁for ▁use ▁by ▁Al lied ▁Land ▁Forces , ▁South - E ast ▁Asia ▁Command ▁in ▁June ▁ 1 9 4 5 . ▁ ▁By ▁December ▁ 1 9 4 5 , ▁ 2 6 8 , 0 0 0 ▁cc ▁had ▁been ▁dispatch ed . ▁ ▁The ▁v acc ine ▁was ▁produced ▁at ▁Well come ' s ▁labor atory ▁at ▁E ly ▁G range ,