▁in ▁a ▁large ▁clin ical ▁coh ort ▁of ▁ 4 1 , 7 0 0 ▁pro state ▁cancer ▁patients . ▁A ▁variety ▁of ▁case ▁reports ▁have ▁associated ▁fl ut am ide ▁with ▁photos ens itivity . ▁Fl ut am ide ▁has ▁been ▁associated ▁with ▁several ▁case ▁reports ▁of ▁m eth em og lo bin emia . ▁B ical ut am ide ▁does ▁not ▁share ▁this ▁risk ▁with ▁fl ut am ide . ▁Fl ut am ide ▁has ▁also ▁been ▁associated ▁with ▁reports ▁of ▁sul f hem og lo bin emia ▁and ▁neut rop enia . ▁ ▁B irth ▁defect s ▁Out ▁of ▁the ▁available ▁end ocr ine - dis rupt ing ▁comp ounds ▁looked ▁at , ▁fl ut am ide ▁has ▁a ▁notable ▁effect ▁on ▁an ogen ital ▁distance ▁in ▁r ats .) ▁ ▁Ph arm ac ology ▁ ▁Ph arm ac od ynam ics ▁ ▁Anti andro gen ic ▁activity ▁ ▁Fl ut am ide ▁acts ▁as ▁a ▁select ive , ▁compet itive , ▁silent ▁ant agon ist ▁of ▁the ▁and ro gen ▁re ceptor ▁( AR ). ▁Its ▁active ▁form , ▁hydro xy fl ut am ide , ▁has ▁between ▁ 1 0 - ▁to ▁ 2 5 - fold ▁higher ▁aff inity ▁for ▁the ▁AR ▁than ▁does ▁fl ut am ide , ▁and ▁hence ▁is ▁a ▁much ▁more ▁pot ent ▁AR ▁ant agon ist ▁in ▁comparison . ▁However , ▁at ▁high ▁concentr ations , ▁unlike ▁fl ut am ide , ▁hydro xy fl ut am ide ▁is ▁able ▁to ▁weak