▁understood . ▁ ▁Cy cl in ▁K ▁also ▁interact s ▁with ▁H IV ▁ne f ▁protein . ▁In ▁the ▁presence ▁of ▁over ex pressed ▁N ef ▁protein , ▁Cy cl in ▁k ▁and ▁CD K 9 ▁binding ▁is ▁induced , ▁in hib iting ▁the ▁positive ▁el ong ation ▁factor ▁of ▁other ▁CD K 9 ▁binding ▁complex es , ▁resulting ▁in ▁an ▁in hib ition ▁of ▁specific ▁H IV - 1 ▁gene ▁expression . ▁ ▁CD K ▁ 1 3 ▁may ▁also ▁be ▁character ized ▁to ▁interact ▁with ▁H IV ▁m R NA ▁sp lic ing , ▁alongside ▁N ef , ▁and ▁the ▁und ere x pression ▁of ▁G ag ▁and ▁En v ▁related ▁prote ins . ▁ ▁Cy cl in ▁K ▁is ▁ind isp ens able ▁for ▁Le uk emia ▁growth . ▁SET D 1 A , ▁is ▁also ▁known ▁to ▁bind ▁Cy cl in ▁K ▁through ▁its ▁F L OS ▁domain . ▁The ▁interaction ▁is ▁shown ▁to ▁be ▁important ▁to ▁DNA ▁damage ▁response ▁gen es ▁and ▁for ▁Le uk emia ▁pro l ifer ation . ▁ ▁References ▁ ▁Further ▁reading ▁ ▁External ▁links <0x0A> </s> ▁The ▁Master ▁System — ren amed ▁and ▁with ▁a ▁red es igned ▁cas ing ▁from ▁the ▁original ▁S ega ▁Mark ▁III , ▁which ▁had ▁been ▁released ▁in ▁the ▁Japanese ▁market ▁in ▁ 1 9 8 5 — is ▁a ▁video ▁game ▁console ▁released ▁by ▁S ega ▁in ▁the ▁North ▁American ▁market ▁in ▁June ▁ 1 9 8 6 ▁to ▁comp ete ▁with ▁the ▁N intendo ▁Entertainment ▁System