▁tum or ▁site , ▁giving ▁rise ▁to ▁the ▁development ▁of ▁secondary ▁met ast atic ▁fo ci ▁in ▁distant ▁org ans ▁and ▁t issues . ▁However , ▁despite ▁the ▁achieved ▁progress , ▁there ▁remain ▁un expl ored ▁questions ▁concerning ▁a ▁possible ▁relationship ▁between ▁different ▁types ▁of ▁invas ive ▁cell ▁growth ▁and ▁the ▁parameters ▁of ▁l ym ph ogen ous ▁and ▁h emat ogen ous ▁met ast asis , ▁the ▁features ▁of ▁disease ▁pro gression , ▁as ▁well ▁as ▁the ▁effic acy ▁of ▁the ▁chosen ▁ther apy . ▁A ▁solution ▁to ▁these ▁problems ▁could ▁be ▁of ▁great ▁help ▁in ▁determ ining ▁the ▁disease ▁pro gn osis ▁and , ▁possibly , ▁developing ▁new ▁approaches ▁to ▁the ▁management ▁of ▁cancer ▁patients . ▁ ▁Ab bre vi ations ▁ ▁E MT <0x09> ep ith el ial - mes en ch ym al ▁transition ▁M ET <0x09> mes en ch ym al - ep ith el ial ▁transition ▁G TP ases <0x09> gu anos ine ▁tri ph osph at ases ▁ ▁See ▁also ▁Per ine ural ▁invasion ▁Met ast asis ▁ ▁References ▁ ▁Category : Can cer ▁path ology ▁Category : On col ogy <0x0A> </s> ▁The ▁ 1 9 8 2 ▁Virginia ▁vs . ▁Cham ina de ▁men ' s ▁basketball ▁game ▁was ▁a ▁college ▁basketball ▁game ▁between ▁the ▁Virginia ▁Cav ali ers ▁of ▁the ▁University ▁of ▁Virginia ▁and ▁the ▁Cham ina de ▁Sil vers words ▁of ▁Cham ina de ▁University ▁of ▁Hon ol ulu . ▁The ▁contest ▁was ▁held ▁on ▁December ▁ 2 3 , ▁ 1