▁Pro long ed ▁a fox olan er - indu ced ▁hyp ere xc itation ▁results ▁in ▁un control led ▁activity ▁of ▁the ▁central ▁nerv ous ▁system ▁and ▁death ▁of ▁insect s ▁and ▁ac ar ines . ▁ ▁Mark eting ▁ ▁A fox olan er ▁is ▁the ▁active ▁principle ▁of ▁the ▁veter inary ▁medic inal ▁products ▁N ex G ard ▁( alone ) ▁and ▁N ex g ard ▁Spect ra ▁( in ▁combination ▁with ▁mil b emy cin ▁ox ime ). ▁They ▁are ▁indicated ▁for ▁the ▁treatment ▁and ▁prevent ion ▁of ▁fle a ▁inf est ations , ▁and ▁the ▁treatment ▁and ▁control ▁of ▁tick ▁inf est ations ▁in ▁dogs ▁and ▁pu pp ies ▁( 8 ▁weeks ▁of ▁age ▁and ▁older , ▁we igh ing ▁ 4 ▁pounds ▁( ~ 1 . 8 ▁kil og rams ) ▁of ▁body ▁weight ▁or ▁greater ) ▁for ▁one ▁month . ▁These ▁products ▁are ▁admin ister ed ▁or ally ▁and ▁po isons ▁fle as ▁once ▁they ▁start ▁feed ing . ▁ ▁The ▁market ing ▁authorization ▁was ▁granted ▁by ▁the ▁European ▁Medic ines ▁Agency ▁in ▁February ▁ 2 0 1 4 ▁for ▁N ex G ard ▁and ▁January ▁ 2 0 1 5 ▁for ▁N ex g ard ▁Spect ra , ▁after ▁only ▁ 1 4 ▁and ▁ 1 2 ▁months ▁of ▁quality , ▁safety ▁and ▁effic acy ▁assess ment ▁performed ▁by ▁the ▁Committee ▁for ▁Medic inal ▁Product s ▁for ▁V eter inary ▁Use ▁( CV MP ). ▁Therefore , ▁long - term ▁effects ▁are ▁not ▁known . ▁ ▁List