▁loss ▁of ▁prote ins ▁in ▁the ▁ur ine ▁caused ▁by ▁ne ph rot ic ▁synd rome ▁results ▁in ▁lower ▁os m otic ▁pressure . ▁Red u ced ▁os m otic ▁pressure ▁will ▁trigger ▁the ▁li ver ▁to ▁produce ▁more ▁prote ins ▁like ▁f ibr in ogen ▁and ▁beta - th rom b og lob ul in , ▁which ▁promote ▁blood ▁cl ot ting . ▁Other ▁than ▁ne ph rot ic ▁synd rome , ▁there ▁are ▁many ▁other ▁factors ▁that ▁can ▁promote ▁hyper co ag ul ability . ▁Hyper co ag ul ability ▁can ▁be ▁promoted ▁by ▁ ▁increased ▁plate let ▁count , ▁en hanced ▁plate let ▁aggreg ation , ▁increased ▁protein ▁S ▁count , ▁and ▁a ▁decrease ▁in ▁co ag ulation ▁in hib it ers ▁like ▁ant ith rom bin . ▁Hyper co ag ul ability ▁can ▁be ▁inherited ▁and / or ▁acquired . ▁Hyper hom oc yst ein emia , ▁a ▁condition ▁known ▁to ▁promote ▁cl ots , ▁can ▁be ▁caused ▁by ▁a ▁combination ▁of ▁gen etic ▁factors ▁and ▁vit amin ▁B 6 , ▁vit amin ▁B 1 2 ▁and ▁fol ic ▁acid ▁def ic iency . ▁F actor ▁V ▁Le idan ▁and ▁mut ations ▁of ▁the ▁pro th rom bin ▁gene ▁are ▁the ▁two ▁most ▁common ▁gen etic ▁causes ▁of ▁hyper co ag ul ability . ▁About ▁ 5 % ▁of ▁the ▁general ▁population ▁have ▁these ▁heter o zy g ous ▁mut ations ▁and ▁in ▁the ▁th rom b oph il ic ▁population , ▁ 4 5 – 6 3 %