▁cells , ▁white ▁blood ▁cells , ▁and ▁plate lets . ▁Red ▁blood ▁cells ▁may ▁show ▁ab normal ities ▁including ▁b izar re ▁shapes , ▁such ▁as ▁te ard rop - sh aped ▁cells , ▁and ▁nucle ated ▁red ▁blood ▁cell ▁prec urs ors ▁may ▁appear ▁in ▁the ▁blood ▁sm ear ▁( le uk o ery th ro bl astic ▁reaction ). ▁Norm ally , ▁m ature ▁red ▁blood ▁cells ▁in ▁adult s ▁do ▁not ▁have ▁a ▁cell ▁nucle us , ▁and ▁the ▁presence ▁of ▁nucle ated ▁red ▁blood ▁cells ▁suggests ▁that ▁imm ature ▁cells ▁are ▁being ▁released ▁into ▁the ▁blood stream ▁in ▁response ▁to ▁a ▁very ▁high ▁demand ▁for ▁the ▁b one ▁mar row ▁to ▁produce ▁new ▁red ▁blood ▁cells . ▁Im m ature ▁white ▁cells ▁and ▁plate lets ▁( large ▁meg ak ary ocy tes ) ▁are ▁also ▁seen ▁in ▁blood ▁samples , ▁and ▁bas oph il ▁counts ▁are ▁increased . ▁ ▁When ▁late ▁in ▁the ▁disease ▁pro gression ▁an ▁attempt ▁is ▁made ▁to ▁take ▁a ▁sample ▁of ▁b one ▁mar row ▁by ▁asp iration , ▁it ▁may ▁result ▁in ▁a ▁dry ▁tap , ▁meaning ▁that ▁where ▁the ▁need le ▁can ▁normally ▁su ck ▁out ▁a ▁sample ▁of ▁semi - liqu id ▁b one ▁mar row , ▁it ▁produces ▁no ▁sample ▁because ▁the ▁mar row ▁has ▁been ▁replaced ▁with ▁col lagen ▁fib ers . ▁A ▁b one ▁mar row ▁bi ops y ▁will ▁reve al ▁col lagen ▁fib ros is , ▁replacing ▁the ▁mar row ▁that ▁would ▁normally ▁occup y ▁the ▁space