▁associated ▁with ▁increased ▁cell ▁migration , ▁ad hes ion ▁and ▁invas iveness . ▁ ▁Several ▁studies ▁have ▁identified ▁M AP 4 K 4 ▁as ▁an ▁up stream ▁reg ulator ▁of ▁prote ins ▁associated ▁with ▁c yt os ke let al ▁dynamics ▁or ▁ad hes ion . ▁De let ion ▁of ▁the ▁M AP 4 K 4 ▁gene ▁appears ▁to ▁affect ▁memb rane ▁dynamics ▁in ▁end oth el ial ▁cells , ▁resulting ▁in ▁reduced ▁cell ▁migration ▁and ▁imp a ired ▁ang i ogen esis ; ▁while ▁an ▁over expression ▁significantly ▁elev ates ▁the ▁rate ▁of ▁cell ▁invasion ▁and ▁morph ogen esis . ▁ ▁Ev idence ▁also ▁indicates ▁that ▁M AP 4 K 4 ▁is ▁a ▁major ▁contrib utor ▁to ▁the ▁elev ated ▁growth ▁and ▁mig rat ory ▁properties ▁of ▁tum our ▁cells . ▁Po or ▁pro gn osis ▁and ▁clin ical ▁pro gression ▁of ▁he pat oc ell ular ▁car cin oma , ▁pan cre atic ▁ad en oc arc in oma , ▁and ▁col ore ct al ▁cancer ▁are ▁all ▁closely ▁correl ated ▁with ▁M AP 4 K 4 ▁expression ▁levels . ▁ ▁References ▁ ▁Further ▁reading ▁ ▁External ▁links <0x0A> </s> ▁At ▁the ▁end ▁of ▁the ▁Chile an ▁Civil ▁War ▁of ▁ 1 8 2 9 – 1 8 3 0 ▁the ▁government ▁decided ▁to ▁buy ▁the ▁brig antine - sch oon er ▁Flora ▁to ▁confront ▁a ▁new ▁attack ▁of ▁ins urg ents . ▁She ▁was ▁renamed ▁Col o ▁Col o . ▁ ▁She ▁brought ▁Cla udio ▁Gay ▁to ▁the ▁Juan ▁Fernández