E th yl male im ide ▁being ▁able ▁to ▁in hib it ▁approximately ▁ 9 5 % ▁of ▁the ▁specific ▁binding ▁of ▁[ 3 H ] M az ind ol ▁to ▁the ▁resid ues ▁of ▁the ▁M AT ▁binding ▁site ( s ), ▁however ▁said ▁effect ▁of ▁ 1 0 ▁m M ▁N - E th yl male im ide ▁was ▁prevent ed ▁in ▁its ▁entire ty ▁by ▁just ▁ 1 0 ▁ μ M ▁c oca ine . ▁Where as ▁neither ▁ 3 0 0 ▁ μ M ▁dop am ine ▁or ▁D - am ph et am ine ▁afford ed ▁sufficient ▁protection ▁to ▁contrast ▁the ▁effic acy ▁of ▁c oca ine . ▁ ▁The ▁above ▁steps ▁in ▁its ▁synth esis ▁show ▁the ▁sim il itude ▁of ▁its ▁prec urs ors ▁to ▁the ▁M AT ▁re upt ake ▁in hib itor ▁pi pr ad rol ▁& ▁related ▁comp ounds . ▁ ▁Local ▁an est het ics ▁( not ▁usually ▁C NS ▁stim ul ants ) ▁▁▁ ▁In ▁animal ▁studies , ▁certain ▁of ▁the ▁local ▁an est het ics ▁have ▁displayed ▁resid ual ▁dop am ine ▁re upt ake ▁in hib itor ▁properties , ▁although ▁not ▁normally ▁ones ▁that ▁are ▁easily ▁available . ▁These ▁are ▁expected ▁to ▁be ▁more ▁card iot ox ic ▁than ▁ph eny lt rop anes . ▁For ▁example , ▁dim eth oca ine ▁has ▁behavior al ▁stim ul ant ▁effects ▁( and ▁therefore ▁not ▁here ▁listed ▁below ) ▁if ▁a ▁do se ▁of ▁it ▁is ▁taken ▁that ▁is ▁