▁in ▁cell ▁bi ology ▁or ▁mole cular ▁bi ology , ▁is ▁a ▁process ▁where by ▁different ▁fra ctions ▁of ▁a ▁bi ological ▁sample ▁become ▁equal ▁in ▁composition . ▁It ▁can ▁be ▁a ▁disease ▁sign ▁in ▁hist op ath ology , ▁or ▁an ▁intent ional ▁process ▁in ▁research : ▁A ▁hom ogen ized ▁sample ▁is ▁equal ▁in ▁composition ▁throughout , ▁so ▁that ▁removing ▁a ▁fraction ▁does ▁not ▁alter ▁the ▁overall ▁mole cular ▁make - up ▁of ▁the ▁sample ▁remaining , ▁and ▁is ▁identical ▁to ▁the ▁fraction ▁removed . ▁Ind u ced ▁hom ogen ization ▁in ▁bi ology ▁is ▁often ▁followed ▁by ▁mole cular ▁extra ction ▁and ▁various ▁analyt ical ▁techniques , ▁including ▁EL IS A ▁and ▁western ▁bl ot . ▁ ▁Method s ▁Hom ogen ization ▁of ▁t issue ▁in ▁solution ▁is ▁often ▁performed ▁simultaneously ▁with ▁cell ▁l ysis . ▁To ▁prevent ▁l ysis ▁however , ▁the ▁t issue ▁( or ▁collection ▁of ▁cells , ▁e . g . ▁from ▁cell ▁culture ) ▁can ▁be ▁kept ▁at ▁temper atures ▁slightly ▁above ▁zero ▁to ▁prevent ▁aut ol ysis , ▁and ▁in ▁an ▁is ot onic ▁solution ▁to ▁prevent ▁os m otic ▁damage . ▁ ▁If ▁free zing ▁the ▁t issue ▁is ▁possible , ▁cry oh om ogen ization ▁can ▁be ▁performed ▁under ▁" d ry " ▁conditions , ▁and ▁is ▁often ▁the ▁method ▁of ▁choice ▁whenever ▁it ▁is ▁des irable ▁to ▁collect ▁several ▁distinct ▁mole cular ▁classes ▁( e . g . ▁both ▁protein ▁and ▁R NA ) ▁from ▁a ▁single ▁sample , ▁or ▁combined