▁conversion ▁of ▁factor ▁IX ▁and ▁factor ▁X ▁into ▁the ▁active ▁prote ases , ▁factor ▁IX a ▁and ▁factor ▁X a , ▁respectively . ▁ ▁The ▁action ▁of ▁the ▁factor ▁is ▁imp eded ▁by ▁t issue ▁factor ▁path way ▁in hib itor ▁( TF PI ), ▁which ▁is ▁released ▁almost ▁immediately ▁after ▁init iation ▁of ▁co ag ulation . ▁F actor ▁VII , ▁which ▁was ▁discovered ▁around ▁ 1 9 5 0 , ▁is ▁vit amin ▁K - dependent ▁and ▁produced ▁in ▁the ▁li ver . ▁Use ▁of ▁war far in ▁or ▁similar ▁ant ico ag ul ants ▁decre ases ▁he p atic ▁synth esis ▁of ▁F V II . ▁ ▁Str ucture ▁ ▁F actor ▁VII ▁shares ▁a ▁common ▁domain ▁architecture ▁with ▁factors ▁IX ▁and ▁X . ▁ ▁Gen et ics ▁▁ ▁The ▁gene ▁for ▁factor ▁VII ▁is ▁located ▁on ▁chrom os ome ▁ 1 3 ▁( 1 3 q 3 4 ). ▁ ▁Ro le ▁in ▁disease ▁▁ ▁F actor ▁VII ▁def ic iency ▁( con gen ital ▁pro convert in ▁def ic iency ) ▁is ▁rare ▁and ▁inherited ▁re cess ively . ▁ ▁It ▁presents ▁as ▁a ▁hem oph ilia - like ▁ble eding ▁dis order . ▁ ▁It ▁is ▁treated ▁with ▁recom bin ant ▁factor ▁VII a ▁( N ovo Se ven ▁or ▁A ry o Se ven ). ▁Gene ▁ther apy ▁approaches ▁for ▁tre ating ▁F V II ▁def ic iency ▁are ▁very ▁prom ising ▁() ▁ ▁Medical ▁uses ▁▁ ▁Re com bin ant ▁factor ▁VII a , ▁market