atic ▁manifest ation ▁of ▁alco hol ▁over consum ption , ▁including ▁fat ty ▁li ver ▁disease , ▁alco hol ic ▁he pat itis , ▁and ▁cir r hos is . ▁Anal og ous ▁terms ▁such ▁as ▁" d rug - indu ced " ▁or ▁" to xic " ▁li ver ▁disease ▁are ▁also ▁used ▁to ▁refer ▁to ▁dis orders ▁caused ▁by ▁various ▁dru gs . ▁ ▁F at ty ▁li ver ▁disease ▁( he p atic ▁ste atos is ) ▁is ▁a ▁revers ible ▁condition ▁where ▁large ▁vac u oles ▁of ▁trig ly cer ide ▁fat ▁accum ulate ▁in ▁li ver ▁cells . ▁Non - al co hol ic ▁fat ty ▁li ver ▁disease ▁is ▁a ▁spectrum ▁of ▁disease ▁associated ▁with ▁ob es ity ▁and ▁met abol ic ▁synd rome . ▁ ▁Her edit ary ▁dise ases ▁that ▁cause ▁damage ▁to ▁the ▁li ver ▁include ▁hem och rom atos is , ▁involving ▁accum ulation ▁of ▁iron ▁in ▁the ▁body , ▁and ▁Wilson ' s ▁disease . ▁Liver ▁damage ▁is ▁also ▁a ▁clin ical ▁feature ▁of ▁alpha ▁ 1 - ant it ry ps in ▁def ic iency ▁ ▁and ▁g ly c ogen ▁storage ▁disease ▁type ▁II . ▁ ▁In ▁tr anst hy ret in - related ▁her edit ary ▁am y lo idos is , ▁the ▁li ver ▁produces ▁a ▁mut ated ▁tr anst hy ret in ▁protein ▁which ▁has ▁severe ▁ne uro de gener ative ▁or ▁card iop ath ic ▁effects . ▁Liver ▁trans plant ation ▁can ▁give ▁a ▁cur ative