▁by ▁this ▁gene ▁is ▁of ▁the ▁k ain ate ▁re ceptor ▁sub type . ▁Re ceptor ▁assembly ▁and ▁int rac ell ular ▁tra ff ick ing ▁of ▁ion otrop ic ▁gl ut am ate ▁re cept ors ▁are ▁reg ulated ▁by ▁R NA ▁editing ▁and ▁alternative ▁sp lic ing . ▁These ▁re cept ors ▁medi ate ▁exc itat ory ▁ne uro trans mission ▁and ▁are ▁critical ▁for ▁normal ▁syn apt ic ▁function . ▁Two ▁altern atively ▁sp lic ed ▁trans cript ▁variants ▁that ▁encode ▁different ▁is o forms ▁have ▁been ▁described . ▁Ex ons ▁of ▁this ▁gene ▁are ▁inter sp ers ed ▁with ▁ex ons ▁from ▁the ▁C 2 1 orf 4 1 ▁gene , ▁which ▁is ▁trans cribed ▁in ▁the ▁same ▁orientation ▁as ▁this ▁gene ▁but ▁does ▁not ▁seem ▁to ▁encode ▁a ▁protein . ▁ ▁Inter actions ▁G RI K 1 ▁has ▁been ▁shown ▁to ▁interact ▁with ▁D L G 4 , ▁P IC K 1 ▁and ▁SD CB P . ▁ ▁R NA ▁editing ▁ ▁Type ▁▁ ▁A ▁to ▁I ▁R NA ▁editing ▁is ▁catal yz ed ▁by ▁a ▁family ▁of ▁ad en os ine ▁de amin ases ▁acting ▁on ▁R NA ▁( AD AR s ) ▁that ▁specifically ▁recognize ▁ad en os ines ▁within ▁double - str and ed ▁regions ▁of ▁pre - m R N As ▁and ▁de amin ate ▁them ▁to ▁in os ine . ▁In os ines ▁are ▁recogn ised ▁as ▁gu anos ine ▁by ▁the ▁cells ▁transl ational ▁mach in ery . ▁There ▁are ▁three ▁members