▁co oper ative ▁group ▁for ▁the ▁purpose ▁of ▁conduct ing ▁radiation ▁ther apy ▁research ▁and ▁clin ical ▁investig ations . ▁Fund ing ▁from ▁the ▁National ▁Can cer ▁Institute ▁( N CI ) ▁began ▁in ▁ 1 9 7 1 . ▁The ▁group ▁has ▁grown ▁consider ably ▁since ▁the ▁activation ▁of ▁its ▁first ▁study ▁in ▁ 1 9 6 8 , ▁an ▁adj uv ant ▁m eth ot re x ate ▁study ▁for ▁head ▁and ▁neck ▁cancer . ▁The ▁m eth ot re x ate ▁study ▁employed ▁combinations ▁of ▁radiation , ▁m eth ot re x ate ▁and ▁surg ery ▁in ▁the ▁treatment ▁of ▁advanced ▁head ▁and ▁neck ▁cancer , ▁and ▁is ▁considered ▁a ▁mil estone ▁in ▁inter dis cipl inary ▁clin ical ▁efforts . ▁The ▁over ▁ 7 0 0 ▁patients ▁accessed ▁to ▁this ▁study ▁formed ▁the ▁bas eline ▁for ▁many ▁of ▁the ▁clin ical ▁investig ations ▁in ▁the ▁area ▁of ▁head ▁and ▁neck ▁cancer ." ▁ ▁" Since ▁its ▁in ception ▁the ▁Group ▁has ▁activ ated ▁ 3 0 0 ▁protocol s ▁and ▁acc ru ed ▁a ▁total ▁of ▁about ▁ 6 0 , 0 0 0 ▁patients ▁to ▁co oper ative ▁group ▁studies ." ▁ ▁" The ▁Group ▁Head quarters ▁and ▁Statist ical ▁Unit ▁are ▁located ▁at ▁the ▁offices ▁of ▁the ▁American ▁College ▁of ▁Rad i ology ▁in ▁Philadelphia , ▁Pennsylvania . ▁The ▁Head quarters ▁Office ▁has ▁been ▁in ▁Philadelphia ▁since ▁the ▁Group ' s ▁in ception , ▁while ▁the ▁current ▁Statist ical ▁Unit ▁was ▁formed ▁in ▁ 1 9 8