▁the ▁identification ▁of ▁new ▁members ▁of ▁the ▁' ant ib i otic - ome ' ▁( defined ▁as ▁natural ▁products ▁with ▁ant ib i otic ▁activity ), ▁and ▁their ▁application ▁in ▁ant ib acter ial ▁drug ▁discovery ▁in ▁the ▁genom ics ▁era . ▁Ph y to chem ical s ▁are ▁the ▁active ▁bi ological ▁component ▁of ▁plants ▁and ▁some ▁ph y to chem ical s ▁including ▁t ann ins , ▁al kal oid s , ▁ter pen oid s , ▁and ▁flav ono ids ▁possess ▁ant im icro b ial ▁activity . ▁Some ▁ant io x id ant ▁di et ary ▁supp lement s ▁also ▁contain ▁ph y to chem ical s ▁( poly phen ols ), ▁such ▁as ▁gra pe ▁seed ▁extract , ▁and ▁demonstrate ▁in ▁vit ro ▁anti - b acter ial ▁properties . ▁Ph y to chem ical s ▁are ▁able ▁to ▁in hib it ▁pe pt id og ly can ▁synth esis , ▁damage ▁micro b ial ▁memb rane ▁structures , ▁modify ▁b acter ial ▁memb rane ▁surface ▁hydro ph ob icity ▁and ▁also ▁mod ulate ▁qu orum ▁sens ing . ▁With ▁increasing ▁ant ib i otic ▁resistance ▁in ▁recent ▁years , ▁the ▁potential ▁of ▁new ▁plant - der ived ▁ant ib iot ics ▁is ▁under ▁investigation . ▁ ▁New ▁ant ib iot ics ▁development ▁Both ▁the ▁W HO ▁and ▁the ▁In fect ious ▁D ise ase ▁Society ▁of ▁America ▁reported ▁that ▁the ▁weak ▁ant ib i otic ▁pipeline ▁does ▁not ▁match ▁b acter ia ' s ▁increasing ▁ability