▁elev ates ▁test oster one ▁levels ▁into ▁the ▁high ▁normal ▁male ▁range ▁via ▁prevent ion ▁of ▁AR ▁activation - medi ated ▁negative ▁feedback ▁on ▁the ▁hypoth al am ic – p itu it ary – gon adal ▁axis ▁in ▁this ▁context . ▁ ▁Other ▁activities ▁Fl ut am ide ▁has ▁been ▁identified ▁as ▁an ▁ag on ist ▁of ▁the ▁ar yl ▁hydro car bon ▁re ceptor . ▁This ▁may ▁be ▁involved ▁in ▁or ▁responsible ▁for ▁the ▁he pat ot ox icity ▁of ▁fl ut am ide . ▁ ▁Ph arm ac ok inet ics ▁The ▁absor ption ▁of ▁fl ut am ide ▁is ▁complete ▁upon ▁or al ▁ing estion . ▁Food ▁has ▁no ▁effect ▁on ▁the ▁bio av ail ability ▁of ▁fl ut am ide . ▁Ste ady - state ▁levels ▁of ▁hydro xy fl ut am ide , ▁the ▁active ▁form ▁of ▁fl ut am ide , ▁are ▁achieved ▁after ▁ 2 ▁to ▁ 4   days ▁administration . ▁Level s ▁of ▁hydro xy fl ut am ide ▁are ▁approximately ▁ 5 0 - fold ▁higher ▁than ▁those ▁of ▁fl ut am ide ▁at ▁steady - state . ▁The ▁pl asma ▁protein ▁binding ▁of ▁fl ut am ide ▁and ▁hydro xy fl ut am ide ▁are ▁high ; ▁ 9 4 ▁to ▁ 9 6 % ▁and ▁ 9 2 ▁to ▁ 9 4 %, ▁respectively . ▁Fl ut am ide ▁is ▁met abol ized ▁by ▁C Y P 1 A 2 ▁( via ▁α - h ydro x yl ation )