cul in ▁in ▁ 1 8 9 0 . ▁In oc ulated ▁into ▁individuals ▁who ▁have ▁had ▁t uber cul osis , ▁it ▁produces ▁a ▁hyp ers ens itivity ▁reaction , ▁and ▁is ▁still ▁used ▁to ▁detect ▁those ▁who ▁have ▁been ▁inf ected . ▁However , ▁Koch ▁used ▁t uber cul in ▁as ▁a ▁v acc ine . ▁This ▁caused ▁serious ▁re actions ▁and ▁death s ▁in ▁individuals ▁whose ▁lat ent ▁t uber cul osis ▁was ▁react iv ated ▁by ▁the ▁t uber cul in . ▁This ▁was ▁a ▁major ▁set back ▁for ▁supp or ters ▁of ▁new ▁v acc ines . ▁Such ▁inc idents ▁and ▁others ▁ens ured ▁that ▁any ▁un t ow ard ▁results ▁concerning ▁v acc ination ▁and ▁related ▁procedures ▁received ▁continued ▁public ity , ▁which ▁grew ▁as ▁the ▁number ▁of ▁new ▁procedures ▁increased . ▁ ▁In ▁ 1 9 5 5 , ▁in ▁a ▁tra ged y ▁known ▁as ▁the ▁C utter ▁incident , ▁C utter ▁Labor ator ies ▁produced ▁ 1 2 0 , 0 0 0 ▁dos es ▁of ▁the ▁S alk ▁pol io ▁v acc ine ▁that ▁in ad vert ently ▁contained ▁some ▁live ▁pol io ▁virus ▁along ▁with ▁in activ ated ▁virus . ▁This ▁v acc ine ▁caused ▁ 4 0 , 0 0 0 ▁cases ▁of ▁pol io , ▁ 5 3 ▁cases ▁of ▁par al ysis , ▁and ▁five ▁death s . ▁The ▁disease ▁spread ▁through ▁the ▁recip ients ' ▁families , ▁creating ▁a ▁pol io ▁ep ide mic ▁that ▁led ▁to ▁a