▁to ▁evaluate ▁the ▁safety ▁and ▁effect iveness ▁of ▁li xiv apt an , ▁when ▁compared ▁to ▁the ▁place bo , ▁in ▁increasing ▁ser um ▁sod ium ▁from ▁bas eline ▁in ▁heart ▁failure ▁patients ▁with ▁hy pon at rem ia . ▁ ▁Pre vious ▁studies ▁In ▁previous ▁studies , ▁li xiv apt an ▁improved ▁blood ▁sod ium ▁levels , ▁lower ed ▁body ▁weight ▁and ▁increased ▁ur ine ▁volume . ▁Those ▁studies ▁suggest ▁that ▁li xiv apt an ▁may ▁play ▁an ▁important ▁role ▁in ▁tre ating ▁hy pon at rem ia ▁and ▁the ▁signs ▁and ▁sympt oms ▁of ▁water ▁ret ention ▁associated ▁with ▁heart ▁failure , ▁Sy nd rome ▁of ▁In app ropri ate ▁Anti - Di ure t ic ▁H orm one ( SI AD H ), ▁and ▁Liver ▁Cir r hos is ▁with ▁As c ites ▁( LC WA ). ▁In ▁clin ical ▁tri als ▁involving ▁patients ▁with ▁water ▁volume ▁over load , ▁li xiv apt an ▁resulted ▁in ▁correction ▁of ▁hy pon at rem ia ▁together ▁with ▁marked ▁aqu ares is . ▁ ▁V apt ans ▁The ▁vas op ress in ▁re ceptor ▁ant agon ists , ▁dub bed ▁v apt ans , ▁target ▁the ▁vas op ress in ▁h orm onal ▁feedback ▁system . ▁Vas op ress in , ▁also ▁called ▁the ▁anti - di ure t ic ▁h orm one ▁or ▁AD H , ▁is ▁an ▁important ▁part ▁of ▁reg ulation ▁in ▁the ▁circul atory ▁system ▁and ▁is ▁integral ▁to ▁the ▁balance ▁of ▁water ▁in ▁the ▁body . ▁As ▁a