▁of ▁ 1 7 0   m g / kg ▁body ▁weight ▁( m ales ) ▁and ▁ 1 9 2   m g / kg ▁body ▁weight ▁( f em ales ), ▁as ▁well ▁as ▁significant ▁increases ▁in ▁ad en omas ▁in ▁the ▁Hard er ian ▁g land ▁( male ▁m ice ▁only ) ▁and ▁in ▁the ▁li ver ▁at ▁median ▁di et ary ▁int akes ▁of ▁ 9 1   m g / kg ▁body ▁weight ▁( m ales ) ▁and ▁ 1 0 1   m g / kg ▁body ▁weight ▁( f em ales ). ▁ ▁The ▁European ▁Union ▁R isk ▁Ass ess ment ▁Report ▁makes ▁a ▁number ▁of ▁observations ▁about ▁this ▁study : ▁it ▁was ▁conducted ▁on ▁a ▁single ▁species ; ▁no ▁studies ▁are ▁available ▁on , ▁for ▁example , ▁r ats ; ▁B 6 C 3 F 1 - stra in ▁m ice ▁are ▁known ▁to ▁be ▁particularly ▁pr one ▁to ▁li ver ▁can cers ; ▁the ▁dos es ▁were ▁high , ▁and ▁to xic ▁effects ▁( es pecially ▁on ▁the ▁li ver ) ▁were ▁observed ▁in ▁the ▁test ▁animals ; ▁the ▁mechanism ▁of ▁tum our ▁development ▁is ▁unclear . ▁ ▁Mus k ▁x yl ene ▁is ▁not ▁gen ot ox ic . ▁It ▁has ▁significant ▁effects ▁on ▁li ver ▁function ▁which ▁are ▁similar ▁to ▁those ▁shown ▁by ▁phen obar b ital , ▁for ▁example , ▁induction ▁of ▁C Y P 2 B 6 ▁and ▁other ▁cy to chrome ▁P 4 5 0 ▁en zym es .