am ide ▁and ▁ 7 5 0   m g / day ▁fl ut am ide ▁( a ▁ 1 5 - fold ▁difference ), ▁circul ating ▁levels ▁of ▁fl ut am ide ▁at ▁steady - state ▁have ▁been ▁found ▁to ▁be ▁approximately ▁ 7 . 5 - fold ▁lower ▁than ▁those ▁of ▁b ical ut am ide . ▁Moreover , ▁whereas ▁fl ut am ide ▁at ▁this ▁dos age ▁has ▁been ▁found ▁to ▁produce ▁a ▁ 7 5 % ▁reduction ▁in ▁pro state - specific ▁ant igen ▁levels ▁in ▁men ▁with ▁pro state ▁cancer , ▁a ▁fall ▁of ▁ 9 0 % ▁has ▁been ▁demonstrated ▁with ▁this ▁dos age ▁of ▁b ical ut am ide . ▁In ▁accord ance , ▁ 5 0   m g / day ▁b ical ut am ide ▁has ▁been ▁found ▁to ▁possess ▁equivalent ▁or ▁superior ▁effect iveness ▁to ▁ 7 5 0   m g / day ▁fl ut am ide ▁in ▁a ▁large ▁clin ical ▁trial ▁for ▁pro state ▁cancer . ▁Also , ▁b ical ut am ide ▁has ▁been ▁shown ▁to ▁be ▁ 5 - fold ▁more ▁pot ent ▁than ▁fl ut am ide ▁in ▁r ats ▁and ▁ 5 0 - fold ▁more ▁pot ent ▁than ▁fl ut am ide ▁in ▁dogs . ▁T aken ▁together , ▁fl ut am ide ▁appears ▁to ▁be ▁a ▁consider ably ▁less ▁pot ent ▁and ▁eff ica cious ▁anti andro gen ▁than ▁is ▁b ical ut am ide . ▁ ▁D ose - r anging ▁studies ▁of