ren oc ort ical ▁car cin oma ▁ ▁( AC C ) ▁is ▁an ▁ag gress ive ▁cancer ▁origin ating ▁in ▁the ▁cor tex ▁( st ero id ▁h orm one - produ cing ▁t issue ) ▁of ▁the ▁ad ren al ▁g land . ▁ ▁Ad ren oc ort ical ▁car cin oma ▁is ▁remarkable ▁for ▁the ▁many ▁h orm onal ▁synd rom es ▁that ▁can ▁occur ▁in ▁patients ▁with ▁ster oid ▁h orm one - produ cing ▁(" function al ") ▁tum ors , ▁including ▁C ushing ' s ▁synd rome , ▁Con n ▁synd rome , ▁vir il ization , ▁and ▁femin ization . ▁Ad ren oc ort ical ▁car cin oma ▁has ▁often ▁inv aded ▁nearby ▁t issues ▁or ▁met ast as ized ▁to ▁distant ▁org ans ▁at ▁the ▁time ▁of ▁diagn osis , ▁and ▁the ▁overall ▁ 5 - year ▁surv ival ▁rate ▁is ▁only ▁ 2 0 – 3 5 %. ▁ ▁Ad ren oc ort ical ▁car cin oma ▁is ▁a ▁rare ▁tum or , ▁with ▁inc idence ▁of ▁one ▁to ▁two ▁per ▁million ▁population ▁ann ually . ▁It ▁has ▁a ▁b im od al ▁distribution ▁by ▁age , ▁with ▁cases ▁clust ering ▁in ▁children ▁under ▁ 5 ▁and ▁in ▁adult s ▁ 3 0 – 4 0 ▁years ▁old . ▁The ▁widely ▁used ▁ang iot ens in - II - respons ive ▁ster oid - produ cing ▁cell ▁line ▁H 2 9 5 R ▁was ▁originally ▁isolated ▁from ▁a ▁tum or ▁diagn osed ▁as ▁ad