▁t uber cul osis ▁the ▁caus ative ▁agent ▁of ▁T uber cul osis ▁men ing itis . ▁ ▁The ▁same ▁mut ation , ▁T 5 9 7 C , ▁was ▁later ▁ ▁observed ▁consist ently ▁with ▁the ▁failure ▁to ▁recognize ▁My c ob acter ium ▁le p ra e , ▁the ▁caus ative ▁agent ▁of ▁Le pro s y . ▁ ▁An ▁Ar gin ine ▁to ▁Gl ut am ine ▁mut ation ▁in ▁T RL 2 , ▁Arg 7 5 3 G ln , ▁was ▁connected ▁to ▁increased ▁ped iat ric ▁Ur inary ▁T ract ▁In fe ctions ▁caused ▁by ▁gram - pos itive ▁b acter ia . ▁ ▁Multiple ▁mut ations ▁in ▁T LR 4 , ▁Asp 2 9 9 G ly ▁and ▁Th r 3 9 9 I le , ▁were ▁imp licated ▁in ▁sus cept ibility ▁to ▁the ▁b acter ial ▁path og ens ▁that ▁cause ▁Period ont itis . ▁ ▁The ▁connection ▁of ▁T LR ▁mut ations ▁to ▁Chron ' s ▁D ise ase ▁has ▁also ▁been ▁investig ated , ▁but ▁has ▁not ▁yield ed ▁conclus ive ▁evidence . ▁The ▁common ▁characteristic ▁between ▁these ▁miss ense ▁mut ations ▁is ▁that ▁the ▁am ino ▁acid ▁resid ues ▁that ▁are ▁subst it uted ▁have ▁not ably ▁different ▁side ▁chain ▁properties , ▁which ▁likely ▁cont ributes ▁to ▁the ▁defect ive ▁T LR ▁protein ▁function . ▁ ▁References ▁ ▁External ▁links ▁▁ ▁YouTube ▁Video : ▁Path ogen ▁Rec ogn ition ▁in ▁a ▁Mac roph age ▁Cell ▁ ▁Category : Cell ▁communication <0x0A> </s>