▁align ments ▁that ▁contain ▁fewer ▁g aps , ▁and ▁fixing ▁mis re present ations ▁in ▁the ▁sequence . ▁ ▁Human ▁reference ▁gen ome ▁The ▁human ▁reference ▁gen ome ▁GR Ch 3 8 ▁was ▁released ▁from ▁the ▁Gen ome ▁Reference ▁Cons ort ium ▁on ▁ 1 7 ▁December ▁ 2 0 1 3 . ▁This ▁build ▁contained ▁around ▁ 2 5 0 ▁g aps , ▁whereas ▁the ▁first ▁version ▁had ▁roughly ▁ 1 5 0 , 0 0 0 ▁g aps . ▁The ▁GR Ch 3 8 ▁assembly ▁saw ▁the ▁closure ▁or ▁reduction ▁of ▁more ▁than ▁ 1 0 0 ▁g aps . ▁Nan op ore ▁sequ encing ▁has ▁seen ▁the ▁closure ▁of ▁ 1 2 ▁g aps ▁in ▁the ▁GR Ch 3 8 ▁reference ▁assembly ▁through ▁the ▁use ▁of ▁ult ra - long ▁reads . ▁ ▁The ▁human ▁reference ▁gen ome ▁is ▁derived ▁from ▁th ir teen ▁anonymous ▁volunte ers ▁from ▁Buff alo , ▁New ▁York . ▁Don ors ▁were ▁rec ru ited ▁by ▁advert is ement ▁in ▁The ▁Buff alo ▁News , ▁on ▁Sunday , ▁March ▁ 2 3 , ▁ 1 9 9 7 . ▁The ▁first ▁ten ▁male ▁and ▁ten ▁female ▁volunte ers ▁were ▁invited ▁to ▁make ▁an ▁appointment ▁with ▁the ▁project ' s ▁gen etic ▁coun sel ors ▁and ▁don ate ▁blood ▁from ▁which ▁DNA ▁was ▁extracted . ▁As ▁a ▁result ▁of ▁how ▁the ▁DNA ▁samples ▁were ▁processed , ▁about ▁ 8 0 ▁percent ▁of ▁the ▁reference ▁gen ome ▁came ▁from ▁eight ▁people ▁and ▁one ▁male , ▁designated ▁R