▁in ▁the ▁li ver ▁during ▁first - pass ▁met abol ism ▁to ▁its ▁main ▁met abol ite ▁hydro xy fl ut am ide ▁( which ▁accounts ▁for ▁ 2 3 % ▁of ▁an ▁or al ▁do se ▁of ▁fl ut am ide ▁one ▁hour ▁post - ing estion ), ▁and ▁to ▁at ▁least ▁five ▁other , ▁minor ▁met abol ites . ▁Fl ut am ide ▁has ▁at ▁least ▁ 1 0   in active ▁met abol ites ▁total , ▁including ▁ 4 - nit ro - 3 - flu oro - m eth yl an il ine . ▁Fl ut am ide ▁is ▁ex cret ed ▁in ▁various ▁forms ▁in ▁the ▁ur ine , ▁the ▁primary ▁form ▁being ▁ 2 - am ino - 5 - nit ro - 4 -( tr if lu or om eth yl ) phen ol . ▁ ▁Fl ut am ide ▁and ▁hydro xy fl ut am ide ▁have ▁elim ination ▁half - l ives ▁of ▁ 4 . 7   h ours ▁and ▁ 6   h ours ▁in ▁adult s , ▁respectively . ▁However , ▁the ▁half - life ▁of ▁hydro xy fl ut am ide ▁is ▁extended ▁to ▁ 8   h ours ▁after ▁a ▁single ▁do se ▁and ▁to ▁ 9 . 6   h ours ▁at ▁steady ▁state ) ▁in ▁elder ly ▁individuals . ▁The ▁elim ination ▁half - l ives ▁of ▁fl ut am ide ▁and ▁hydro xy fl ut am ide ▁are ▁regarded ▁as ▁too ▁short ▁to ▁allow ▁for ▁once