▁former ▁even ▁being ▁less ▁than ▁the ▁ 0 . 1 7 ▁of ▁morph ine ▁that ▁code ine ▁is ); ▁with ▁the ▁final ▁possible ▁stand ▁alone ▁intermediate ▁comp ound ▁between ▁code ine ▁& ▁o xy cod one ▁( i . e . ▁ 7 , 8 - d ih ydro code ine ) ▁being ▁at ▁most ▁ 1 5 0 % ▁to ▁ 2 0 0 % ▁that ▁of ▁code ine . ▁ ▁ben zo yl ▁phen yl - alter ations ▁ ▁The ▁nap h th al ene ▁anal ogs ▁allow ▁for ▁further ▁numeric ▁substitution s , ▁including ▁eight ▁position ▁peri ▁subst it uted ▁patterns . ▁Many ▁more ▁alter ations ▁creating ▁differ ing ▁a rom atic ▁rings ▁are ▁possible . ▁ ▁Ben zo yl ▁branch ▁modifications ▁▁▁ ▁Ben zo yl th iom eth yle c gon ine ▁ ▁A ▁sul fur ▁in ▁place ▁of ▁the ▁o xygen ▁at ▁the ▁ben zo yl ▁est er ▁single ▁bond ▁results ▁in ▁a ▁lower ▁electron eg ativity ▁than ▁that ▁of ▁c oca ine . ▁ ▁C 1 - t rop ane - ring ▁hydro gen — subst itution s ▁ ▁c f . ▁hydro xy t rop ac oca ine ▁for ▁a ▁natural ▁al kal oid ▁( lack ing ▁however , ▁the ▁ 2 - position ▁car bm eth ox y ) ▁that ▁is ▁a ▁C 1 ▁subst itu ent ▁with ▁a ▁hydro xy ▁group . ▁▁ ɑ , ▁P ▁< ▁ 0 . 0 5 ▁compared ▁with ▁( — )- c oca ine ▁( one - way