Fig . ▁ 1 ). <0x09> ▁ <0x09> ▁These ▁changes ▁are ▁described ▁as ▁am o eb oid - mes en ch ym al ▁and ▁mes en ch ym al - amo eb oid ▁trans itions . ▁T um or ▁cells ▁using ▁the ▁mes en ch ym al ▁type ▁of ▁migration ▁can ▁be ▁changed ▁in ▁a ▁certain ▁way ▁and ▁shift ▁to ▁the ▁am o eb oid ▁type ▁of ▁movement ▁under ▁conditions ▁of ▁a ▁weak ened ▁signal ▁and ▁mechanical ▁path ways ▁that ▁are ▁directly ▁involved ▁in ▁the ▁stabil ization ▁of ▁the ▁interactions ▁between ▁ext rac ell ular ▁matrix ▁structures ▁and ▁m align ant ▁cells . ▁However , ▁the ▁available ▁data ▁were ▁obtained ▁primarily ▁by ▁means ▁of ▁experiments . ▁The ▁following ▁mechan isms ▁leading ▁to ▁the ▁transition ▁of ▁cells ▁from ▁the ▁mes en ch ym al ▁to ▁the ▁am o eb oid ▁type ▁of ▁invas ive ▁growth ▁( mes en ch ym al - amo eb oid ▁transition ) ▁have ▁been ▁described : ▁ 1 ) ▁reduction ▁in ▁or ▁complete ▁abol ition ▁of ▁per ic ell ular ▁prote ol ysis ▁due ▁to ▁application ▁of ▁prote ase ▁in hib itors ; ▁ 2 ) ▁reduction ▁in ▁the ▁activity ▁of ▁integr in ▁re cept ors ▁and ▁their ▁interactions ▁with ▁surrounding ▁st rom al ▁elements ▁by ▁their ▁ant agon ists ; ▁ 3 ) ▁increase ▁in ▁and ▁stabil ization ▁of ▁the ▁activity ▁of ▁small ▁G TP ase ▁R ho A ▁and ▁its ▁RO CK ▁effect or . ▁A ▁study ▁by ▁S . ▁Bert on ’ s ▁group ▁provided ▁an