▁as ▁a ▁form ▁of ▁combined ▁and ro gen ▁block ade ▁and ▁as ▁an ▁alternative ▁to ▁the ▁combination ▁of ▁fl ut am ide ▁with ▁surg ical ▁or ▁medical ▁cas tr ation . ▁ ▁Sk in ▁and ▁hair ▁conditions ▁Fl ut am ide ▁has ▁been ▁research ed ▁and ▁used ▁extens ively ▁in ▁the ▁treatment ▁of ▁and ro gen - dependent ▁skin ▁and ▁hair ▁conditions ▁in ▁women ▁including ▁ac ne , ▁se bor r he a , ▁h irs ut ism , ▁and ▁scal p ▁hair ▁loss , ▁as ▁well ▁as ▁in ▁hyper andro gen ism ▁( e . g ., ▁in ▁pol yc yst ic ▁ov ary ▁synd rome ▁or ▁con gen ital ▁ad ren al ▁hyper pl asia ), ▁and ▁is ▁effective ▁in ▁impro ving ▁the ▁sympt oms ▁of ▁these ▁conditions . ▁The ▁dos ages ▁used ▁are ▁lower ▁than ▁those ▁used ▁in ▁the ▁treatment ▁of ▁pro state ▁cancer . ▁Although ▁fl ut am ide ▁continues ▁to ▁be ▁used ▁for ▁these ▁indic ations , ▁its ▁use ▁in ▁recent ▁years ▁has ▁been ▁limited ▁due ▁to ▁the ▁risk ▁of ▁potentially ▁fatal ▁he pat ot ox icity , ▁and ▁it ▁is ▁no ▁longer ▁recommended ▁as ▁a ▁first - ▁or ▁second - line ▁ther apy . ▁The ▁related ▁NS AA ▁b ical ut am ide ▁has ▁also ▁been ▁found ▁to ▁be ▁effective ▁in ▁the ▁treatment ▁of ▁h irs ut ism ▁in ▁women ▁and ▁appears ▁to ▁have ▁compar able ▁effect iveness ▁to ▁that ▁of ▁fl ut am ide , ▁but ▁has ▁a ▁far ▁lower ▁and ▁only ▁small ▁risk ▁of ▁he