▁migration . <0x09> ▁ <0x09> ▁It ▁is ▁worth ▁not ing ▁that ▁migration ▁through ▁the ▁am o eb oid ▁mechanism ▁of ▁invasion ▁is ▁accompanied ▁by ▁changes ▁not ▁only ▁in ▁the ▁cell ▁shape , ▁but ▁also ▁in ▁the ▁shape ▁of ▁the ▁nucle us ▁and ▁its ▁orientation ▁and ▁position ▁relative ▁to ▁other ▁internal ▁organ elles . ▁The ▁nucle us , ▁which ▁is ▁the ▁largest ▁and ▁st iffer , ▁compared ▁to ▁the ▁surrounding ▁c yt os ke leton , ▁organ elle , ▁is ▁mechan ically ▁firm ly ▁stabil ized ▁by ▁an ▁extensive ▁network ▁of ▁struct ural ▁prote ins , ▁and , ▁for ▁this ▁reason , ▁its ▁shape , ▁most ▁likely , ▁often ▁does ▁not ▁under go ▁significant ▁changes . ▁However , ▁the ▁am o eb oid ▁type ▁of ▁migration ▁is ▁character ized ▁by ▁the ▁most ▁pron ounced ▁nucle us ▁de formation , ▁caused ▁by ▁the ▁lack ▁of ▁prote ol yt ic ▁de grad ation ▁of ▁the ▁surrounding ▁matrix . ▁Since ▁tum or ▁cells ▁have ▁to ▁move ▁through ▁narrow ▁spaces ▁and ▁por es , ▁the ▁nucle us ▁in ▁this ▁case ▁also ▁occurs ▁in ▁a ▁maximum ▁com pressed ▁state . ▁It ▁is ▁assumed ▁that , ▁like ▁the ▁am o eb oid ▁movement ▁of ▁le uk ocy tes , ▁nuc lei ▁inside ▁single ▁migr ating ▁tum or ▁cells ▁move ▁forward ▁toward ▁the ▁leading ▁edge . <0x09> ▁ <0x09> ▁In ▁contrast ▁to ▁the ▁mes en ch ym al ▁movement , ▁am o eb oid ▁or ▁a ▁non - prote ol yt ic ▁model ▁of ▁migration ▁prev ails ▁when ▁the ▁surrounding ▁matrix