las mic ▁ret icul um ▁stress ▁and ▁ins ul in ▁resistance ▁in ▁the ▁li ver . ▁ ▁Ro le ▁in ▁li pop rote ins ▁and ▁a ther os cl eros is ▁ ▁A po B 1 0 0 ▁is ▁found ▁in ▁li pop rote ins ▁origin ating ▁from ▁the ▁li ver ▁( V LD L , ▁ID L , ▁L DL ). ▁Import antly , ▁there ▁is ▁one ▁A po B 1 0 0 ▁mole c ule ▁per ▁he p atic - der ived ▁li pop rote in . ▁Hence , ▁using ▁that ▁fact , ▁one ▁can ▁quant ify ▁the ▁number ▁of ▁li pop rote in ▁particles ▁by ▁not ing ▁the ▁total ▁A po B 1 0 0 ▁concentration ▁in ▁the ▁circul ation . ▁Since ▁there ▁is ▁one ▁and ▁only ▁one ▁A po B 1 0 0 ▁per ▁particle , ▁the ▁number ▁of ▁particles ▁is ▁reflected ▁by ▁the ▁A po B 1 0 0 ▁concentration . ▁The ▁same ▁technique ▁can ▁be ▁applied ▁to ▁individual ▁li pop rote in ▁classes ▁( e . g . ▁L DL ) ▁and ▁thereby ▁enable ▁one ▁to ▁count ▁them ▁as ▁well . ▁ ▁It ▁is ▁well ▁established ▁that ▁A po B 1 0 0 ▁levels ▁are ▁associated ▁with ▁coron ary ▁heart ▁disease , ▁they ▁are ▁a ▁far ▁better ▁predict or ▁of ▁it ▁than ▁are ▁L DL - C ▁concentr ations ▁. ▁Re ason : ▁L CL - C ▁does ▁not ▁reflect ▁actual ▁particle ▁concentr ations ▁& ▁ch ol ester ol ▁cannot ▁dissol ve ▁or ▁move ▁( in ▁water