▁They ▁thought ▁that ▁further ▁development ▁of ▁P . ▁mal aria e ▁can ▁occur ▁when ▁pl asma ▁concentr ations ▁of ▁the ▁anti - mal arial s ▁gradually ▁decrease ▁after ▁the ▁anti - mal arial ▁medic ations ▁are ▁taken . ▁According ▁to ▁Dr . ▁William ▁E . ▁Collins ▁from ▁the ▁Center ▁of ▁D ise ase ▁Control ▁( CD C ), ▁ch lor o qu ine ▁is ▁most ▁commonly ▁used ▁for ▁treatment ▁and ▁no ▁evidence ▁of ▁resistance ▁to ▁this ▁drug ▁has ▁been ▁found . ▁In ▁that ▁event , ▁it ▁is ▁possible ▁that ▁the ▁results ▁from ▁Müller - St ö ver ▁et ▁al . ▁provided ▁isolated ▁inc id ences . ▁ ▁Public ▁health , ▁prevent ion ▁strateg ies ▁and ▁v acc ines ▁The ▁food ▁vac u ole ▁is ▁the ▁special ized ▁compart ment ▁that ▁de gr ades ▁hem og lo bin ▁during ▁the ▁a sex ual ▁er yth ro cy t ic ▁stage ▁of ▁the ▁par as ite . ▁It ▁is ▁imp lied ▁that ▁effective ▁drug ▁treat ments ▁can ▁be ▁developed ▁by ▁target ing ▁the ▁prote ol yt ic ▁en zym es ▁of ▁the ▁food ▁vac u ole . ▁In ▁a ▁paper ▁published ▁in ▁ 1 9 9 7 , ▁West ling ▁et ▁al . ▁focused ▁their ▁attention ▁on ▁the ▁as part ic ▁end ope pt id ase ▁class ▁of ▁en zym es , ▁simply ▁called ▁pl as me ps ins . ▁They ▁sought ▁to ▁character ize ▁the ▁specific ity ▁for ▁the ▁en zym es ▁cl oned ▁from ▁P . ▁viv ax ▁and ▁P . ▁mal aria