3 ▁and ▁extended ▁over ▁SR   3 0 3 ▁in ▁ 1 9 9 1 ▁to ▁SR   3 ▁after ▁SR   3 0 3 ▁was ▁moved ▁south ▁to ▁end ▁in ▁Silver dale . ▁ ▁Major ▁inter sections ▁ ▁References ▁ ▁External ▁links ▁ ▁High ways ▁of ▁Washington ▁State ▁▁ 3 0 8 ▁Category : Transport ation ▁in ▁K its ap ▁County , ▁Washington <0x0A> </s> ▁AP OB EC ▁(" ap ol ip op rote in ▁B ▁m R NA ▁editing ▁en zym e , ▁catal yt ic ▁pol ype pt ide - like ") ▁is ▁a ▁family ▁of ▁evolution arily ▁conser ved ▁c yt id ine ▁de amin ases . ▁ ▁A ▁mechanism ▁of ▁generating ▁protein ▁divers ity ▁is ▁m R NA ▁editing . ▁ ▁M embers ▁of ▁this ▁family ▁are ▁C - to - U ▁editing ▁en zym es . ▁ ▁The ▁N - term inal ▁domain ▁of ▁AP OB EC ▁like ▁prote ins ▁is ▁the ▁catal yt ic ▁domain , ▁while ▁the ▁C - term inal ▁domain ▁is ▁a ▁pseud oc atal yt ic ▁domain . ▁More ▁specifically , ▁the ▁catal yt ic ▁domain ▁is ▁a ▁z inc ▁dependent ▁c yt id ine ▁de amin ase ▁domain ▁and ▁is ▁essential ▁for ▁c yt id ine ▁de am ination . ▁R NA ▁editing ▁by ▁AP OB EC - 1 ▁requires ▁hom od imer isation ▁and ▁this ▁complex ▁interact s ▁with ▁R NA ▁binding ▁prote ins ▁to ▁form ▁the ▁edit os ome . ▁ ▁In ▁humans / m amm als ▁they ▁help