▁des i pr am ine ▁@ ▁N ET ▁= ▁ 2 . 7 4 ▁ ± ▁ 0 . 5 9 ▁( n ▁= ▁ 3 ) ▁C oca ine ▁anal ogs ▁subst itut ing ▁the ▁C 1 - t rop ane ▁ring ▁position , ▁requiring ▁sul fin im ine ▁( N - s ul fin yl - im ine ) ▁chem istry ▁( before ▁the ▁innov ation ▁of ▁which ▁were ▁un ten able ) ▁which ▁bind ▁unlike ▁the ▁typical ▁configuration ▁at ▁DAT ▁( open ▁to ▁out ) ▁as ▁c oca ine ▁( with ▁its ▁terminal ▁D 7 9 - Y 1 5 6 ▁distance ▁of ▁ 6 . 0 3 ▁Å ), ▁or ▁in ▁the ▁at yp ical ▁( closed ▁to ▁out ) ▁con formation ▁of ▁the ▁ben zt rop ines ▁( 3 . 2 9 ▁Å ). ▁Though ▁closer ▁to ▁the ▁open ▁to ▁out : ▁( — )- 1 - m eth yl - c oca ine ▁= ▁ 4 . 4 0 ▁Å ▁& ▁( — )- 1 - phen yl - c oca ine ▁= ▁ 4 . 8 9 ▁Å , ▁and ▁exhib iting ▁prefer ential ▁interaction ▁with ▁out ward ▁facing ▁DAT ▁con formation , ▁they ▁appear ▁to ▁have ▁the ▁lack ▁of ▁behavior al ▁stim ulation ▁as - like ▁the ▁closed ▁to ▁out ▁type . ▁Despite ▁having ▁non - st im ul ant ▁behavior ▁profiles , ▁they ▁still ▁seem ▁to ▁have ▁anti - de press ant ▁behavior al ▁profiles . ▁ ▁The ▁C 1 ▁phen yl ▁analog ▁is