ention ▁of ▁E c ad her in ▁expression . <0x09> ▁ <0x09> ▁Data ▁have ▁been ▁reported ▁indicating ▁that ▁collect ively ▁migr ating ▁cancer ▁cells ▁can ▁use ▁the ▁ability ▁of ▁adjacent ▁mes en ch ym al ▁cells ▁to ▁modify ▁the ▁structure ▁of ▁the ▁matrix ▁and ▁re build ▁it , ▁and ▁then ▁follow ▁in ▁their ▁“ foot steps .” ▁In ▁in ▁vit ro ▁experiments , ▁the ▁introduction ▁of ▁fib ro bl asts ▁in ▁the ▁culture ▁indu ces ▁collect ive ▁tum or ▁cell ▁migration ▁to ▁the ▁underlying ▁matrix ▁in ▁the ▁form ▁of ▁ch ains . ▁Therefore , ▁fib ro bl asts ▁are ▁a ▁“ guide ” ▁for ▁inv ading ▁tum or ▁cells , ▁rem od eling ▁the ▁surrounding ▁ext rac ell ular ▁matrix ▁to ▁path ways ▁with ▁thick ▁col lagen ▁bund les ▁on ▁the ▁sides ▁and ▁a ▁lack ▁of ▁a ▁matrix ▁in ▁the ▁center . <0x09> ▁ <0x09> ▁LIM - kin ase , ▁a ▁member ▁of ▁one ▁of ▁the ▁protein ▁families , ▁plays ▁a ▁role ▁in ▁the ▁development ▁of ▁collect ive ▁migration ▁by ▁tum or ▁cells . ▁This ▁protein ▁is ▁known ▁to ▁be ▁involved ▁in ▁the ▁reg ulation ▁of ▁developing ▁inv ad op od ias , ▁which ▁are ▁structures ▁typical ▁of ▁m align ant ▁tum or ▁cells ▁and ▁responsible ▁for ▁the ▁destruction ▁of ▁the ▁surrounding ▁ext rac ell ular ▁matrix . ▁Ex cess ive ▁activation ▁of ▁LIM - kin ase ▁is ▁displayed ▁in ▁breast ▁cancer . ▁Bre ast ▁tum or ▁cells ▁with ▁suppress ed ▁expression ▁of ▁the ▁LIM - kin ase ▁gene ▁lose ▁their ▁ability ▁to