1 0 1 ; ▁Cy cl ur ad ) ▁– ▁N MD A ▁re ceptor ▁g ly c ine ▁site ▁partial ▁ag on ist ▁and ▁AA ▁combination ▁– ▁specifically ▁under ▁development ▁for ▁the ▁treatment ▁of ▁de press ive ▁episodes ▁in ▁b ip olar ▁dis order ▁ ▁De xt rom eth orph an / quin id ine ▁( AV P - 7 8 6 / AV P - 9 2 3 ) ▁– ▁ σ 1 ▁re ceptor ▁ag on ist , ▁SN RI , ▁un comp et itive ▁N MD A ▁re ceptor ▁ant agon ist , ▁and ▁other ▁actions ▁ ▁Not ▁under ▁development ▁The ▁following ▁dru gs ▁are ▁currently ▁of ▁investig ational ▁interest ▁as ▁potential ▁ant ide press ants ▁but ▁are ▁not ▁formally ▁under ▁clin ical ▁development ▁for ▁appro val ▁at ▁this ▁time : ▁▁▁ 7 , 8 - D ih ydro xy f lav one ▁( 7 , 8 - D H F ) ▁– ▁Tr k B ▁ag on ist ▁ ▁Min ocy cl ine ▁– ▁micro gl ia ▁in hib itor ▁and ▁other ▁actions ; ▁a ▁ 2 0 1 8 ▁system atic ▁review ▁and ▁meta - analysis ▁reported ▁that ▁the ▁overall ▁ant ide press ant ▁effect ▁size ▁of ▁min ocy cl ine ▁compared ▁to ▁place bo ▁was ▁- 0 . 7 8 ▁( 9 5 % ▁CI : ▁- 0 . 4 ▁to ▁- 1 . 3 3 , ▁P = 0 . 0 0 5 ), ▁indic ative ▁of ▁a ▁large ▁and ▁statist ically ▁significant ▁ant ide