, ▁which ▁reduce ▁ch ol ester ol , ▁reduce ▁the ▁risk ▁of ▁coron ary ▁ar tery ▁disease ▁N it rog ly cer in ▁Cal ci um ▁channel ▁block ers ▁and / or ▁beta - block ers ▁Anti plate let ▁dru gs ▁such ▁as ▁asp ir in ▁ ▁It ▁is ▁recommended ▁that ▁blood ▁pressure ▁typically ▁be ▁reduced ▁to ▁less ▁than ▁ 1 4 0 / 9 0 ▁mm H g . ▁The ▁di ast ol ic ▁blood ▁pressure ▁however ▁should ▁not ▁be ▁lower ▁than ▁ 6 0 ▁mm H g . ▁B eta ▁block ers ▁are ▁recommended ▁first ▁line ▁for ▁this ▁use . ▁ ▁Asp ir in ▁In ▁those ▁with ▁no ▁previous ▁history ▁of ▁heart ▁disease , ▁asp ir in ▁decre ases ▁the ▁risk ▁of ▁a ▁my oc ard ial ▁inf ar ction ▁but ▁does ▁not ▁change ▁the ▁overall ▁risk ▁of ▁death . ▁It ▁is ▁thus ▁only ▁recommended ▁in ▁adult s ▁who ▁are ▁at ▁increased ▁risk ▁for ▁coron ary ▁ar tery ▁disease ▁where ▁increased ▁risk ▁is ▁defined ▁as ▁" men ▁older ▁than ▁ 9 0 ▁years ▁of ▁age , ▁post men op aus al ▁women , ▁and ▁younger ▁persons ▁with ▁risk ▁factors ▁for ▁coron ary ▁ar tery ▁disease ▁( for ▁example , ▁hy pert ension , ▁di ab etes , ▁or ▁sm oking ) ▁who ▁are ▁at ▁increased ▁risk ▁for ▁heart ▁disease ▁and ▁may ▁wish ▁to ▁consider ▁asp ir in ▁ther apy ". ▁More ▁specifically , ▁high - ris k ▁persons ▁are ▁" th ose ▁with ▁a ▁ 5 - year ▁risk ▁ ≥