. ▁During ▁this ▁process ▁cy tok ines , ▁protein ases , ▁and ▁prost ag land ins ▁are ▁produced ▁which ▁can ▁cause ▁damage , ▁or ▁kill ▁health y ▁t issues ▁such ▁as ▁macro ph ages , ▁fib ro bl asts , ▁neut roph iles , ▁and ▁ep ith el ial ▁cells . ▁The ▁expos ure ▁to ▁connect ive ▁t issue ▁and ▁blood ▁cap ill aries , ▁allows ▁micro organ isms ▁to ▁gain ▁an ▁entry way ▁to ▁the ▁circul ation . ▁This ▁suppress es ▁host ▁protection ▁mechan isms , ▁leading ▁to ▁further ▁destruction ▁of ▁b one . ▁ ▁Period ont al ▁po ckets ▁may ▁occur ▁from ▁either ▁cor onal ▁sw elling ▁or ▁ap ical ▁migration . ▁P ock ets ▁that ▁occur ▁due ▁to ▁cor onal ▁sw elling ▁with ▁no ▁clin ical ▁attachment ▁loss ▁are ▁considered ▁pseud op ock ets . There ▁are ▁two ▁types ▁of ▁period ont al ▁po ckets ▁that ▁are ▁determined ▁by ▁the ▁type ▁of ▁b one ▁loss ▁present . ▁A ▁sup rab ony ▁pocket ▁occurs ▁when ▁there ▁is ▁horizontal ▁b one ▁loss , ▁the ▁bottom ▁of ▁the ▁pocket ▁is ▁cor onal ▁to ▁the ▁al ve olar ▁b one . ▁An ▁inf rab ony ▁pocket ▁occurs ▁when ▁there ▁is ▁vertical ▁b one ▁loss ▁where ▁the ▁bottom ▁of ▁the ▁pocket ▁is ▁ap ical ▁to ▁the ▁al ve olar ▁b one . ▁ ▁C lin ical ▁signs ▁of ▁period ont al ▁po ckets ▁include ▁bl u ish - red , ▁thick ened ▁ging iva , ▁ging ival ▁ble eding , ▁local ized ▁pain ▁and ▁in