▁integrity ▁of ▁the ▁ep ith el ial ▁cell ▁layer , ▁allowing ▁for ▁ ▁invasion ▁and ▁colon ization . ▁ ▁E col ogy ▁ ▁P . ▁ging ival is ▁plays ▁an ▁important ▁role ▁in ▁the ▁on set ▁of ▁chron ic ▁adult ▁period ont itis . ▁Though ▁it ▁is ▁found ▁in ▁low ▁abund ance ▁in ▁the ▁or al ▁cav ity , ▁it ▁causes ▁a ▁micro b ial ▁shift ▁of ▁the ▁or al ▁cav ity , ▁allowing ▁for ▁un control led ▁growth ▁of ▁the ▁comm ens al ▁micro b ial ▁community . ▁This ▁leads ▁to ▁period ont itis ▁through ▁the ▁dis ruption ▁of ▁the ▁host ▁t issue ▁home ost asis ▁and ▁adapt ive ▁imm une ▁response . ▁After ▁using ▁las er ▁capture ▁micro dis section ▁plus ▁q RT - PC R ▁to ▁detect ▁P . ▁ging ival is ▁in ▁human ▁bi ops ies , ▁col ocal ization ▁of ▁P . ▁ging ival is ▁with ▁CD 4 + ▁T ▁cells ▁was ▁observed . ▁However , ▁the ▁in fection ▁mechanism ▁of ▁T ▁cells ▁by ▁P . ▁ging ival is ▁remains ▁unknown . ▁ ▁P . ▁ging ival is ▁has ▁been ▁associated ▁with ▁increasing ▁the ▁vir ul ence ▁of ▁other ▁comm ens al ▁b acter ia ▁in ▁both ▁in ▁v ivo ▁and ▁in ▁vit ro ▁experiments . ▁P . ▁ging ival is ▁outer ▁memb rane ▁ves icles ▁ ▁were ▁found ▁to ▁be ▁necessary ▁for ▁the ▁invasion ▁of ▁ep ith el ial ▁cells ▁of ▁T anner ella ▁for s yth ia . ▁P . ▁ging ival is ▁short ▁f imb