▁showed ▁no ▁benefit , ▁while ▁a ▁small ▁benefit ▁was ▁shown ▁with ▁adding ▁anti and rog ens ▁to ▁G n R H ▁analog ues . ▁ ▁Unfortunately , ▁ther ap ies ▁which ▁lower ▁test oster one ▁levels , ▁such ▁as ▁orch ie ct omy ▁or ▁G n R H ▁analog ue ▁administration , ▁also ▁have ▁significant ▁side ▁effects . ▁Comp ared ▁to ▁these ▁ther ap ies , ▁treatment ▁with ▁anti and rog ens ▁exhib its ▁" fe wer ▁hot ▁flash es , ▁less ▁of ▁an ▁effect ▁on ▁lib ido , ▁less ▁mus cle ▁was ting , ▁fewer ▁person ality ▁changes , ▁and ▁less ▁b one ▁loss ." ▁However , ▁anti andro gen ▁ther apy ▁alone ▁is ▁less ▁effective ▁than ▁surg ery . ▁Nevertheless , ▁given ▁the ▁advanced ▁age ▁of ▁many ▁with ▁pro state ▁cancer , ▁as ▁well ▁as ▁other ▁features , ▁many ▁men ▁may ▁choose ▁anti andro gen ▁ther apy ▁alone ▁for ▁a ▁better ▁quality ▁of ▁life . ▁ ▁Fl ut am ide ▁has ▁been ▁found ▁to ▁be ▁similarly ▁effective ▁in ▁the ▁treatment ▁of ▁pro state ▁cancer ▁to ▁b ical ut am ide , ▁although ▁indic ations ▁of ▁inferior ▁effic acy , ▁including ▁greater ▁compens atory ▁increases ▁in ▁test oster one ▁levels ▁and ▁greater ▁redu ctions ▁in ▁P SA ▁levels ▁with ▁b ical ut am ide , ▁were ▁observed . ▁The ▁medic ation , ▁at ▁a ▁dos age ▁of ▁ 7 5 0   m g / day ▁( 2 5 0   m g ▁three ▁times ▁daily ), ▁has ▁also ▁been ▁found ▁to