ar box yl ate ▁is ▁t et ram eth yl quin ol iz ine - 1 , 2 , 3 , 4 - t et rac ar box yl ate , ▁which ▁on ▁ox id ation ▁with ▁dil ute ▁nit ric ▁acid ▁is ▁converted ▁into ▁trim eth yl ▁ind ol iz ine - tr ic ar box yl ate . ▁This , ▁on ▁hydro ly s is ▁and ▁dec ar box yl ation , ▁furn ishes ▁ind ol iz ine , ▁the ▁oct ah ydro - der iv ate ▁of ▁which , ▁also ▁known ▁as ▁oct ah yd rop yr ro col ine ▁is ▁converted ▁by ▁the ▁cy an ogen ▁b rom ide ▁method ▁success ively ▁into ▁the ▁b rom ocy ano am ide , ▁cy ano am ide ▁and ▁rac .- con i ine . ▁A ▁synth esis ▁of ▁the ▁al kal oid , ▁starting ▁from ▁ind ol iz ine ▁( py r ro col ine ) ▁is ▁described ▁by ▁O ch iai ▁and ▁Ts uda . ▁ ▁The ▁prepar ation ▁of ▁L -( R )- con i ine ▁by ▁the ▁reduction ▁of ▁ β - con ice ine ▁( L - pro pen yl pi per id ine ) ▁by ▁L öff ler ▁and ▁Friedrich ▁is ▁interesting ▁as ▁a ▁means ▁of ▁converting ▁con h yd r ine ▁to ▁L -( R )- con i ine . ▁H ess ▁and ▁E ich el ▁reported , ▁incorrectly , ▁that ▁pel let ier ine ▁was ▁the ▁al de hy de ▁( β - 2