▁pro l ifer ation ▁and ▁apo pt osis . ▁Com ponents ▁of ▁the ▁Hi ppo ▁path way ▁are ▁highly ▁conser ved ▁in ▁m amm al ian ▁cells . ▁Act ing ▁down ▁stream ▁of ▁the ▁Hi ppo ▁path way ▁is ▁the ▁Y AP ▁on c ogene , ▁which ▁enc odes ▁a ▁trans cription ▁co - activ ator . ▁ ▁Their ▁recent ▁studies ▁have ▁shown ▁that ▁reg ulation ▁of ▁Y AP ▁by ▁the ▁Hi ppo ▁path way ▁plays ▁a ▁critical ▁role ▁in ▁cell ▁contact ▁in hib ition . ▁Furthermore , ▁Y AP ▁is ▁elev ated ▁in ▁many ▁human ▁can cers . ▁The ▁main ▁focus ▁of ▁this ▁project ▁is ▁to ▁el uc id ate ▁the ▁phys i ological ▁reg ulation ▁of ▁the ▁Hi ppo ▁path way ▁and ▁to ▁understand ▁how ▁d ys reg ulation ▁of ▁the ▁path way ▁cont ributes ▁to ▁tum or igen esis . ▁ ▁References ▁ ▁External ▁links ▁ ▁Kun - Li ang ▁Gu an ' s ▁home page ▁at ▁U C SD ▁ ▁Bio chem ist ▁Kun - Li ang ▁Gu an ▁named ▁a ▁Mac Ar thur ▁Fellow ▁ ▁Kun - Li ang ▁Gu an ' s ▁home page ▁at ▁U M ▁▁▁ ▁Category : 1 9 6 3 ▁birth s ▁Category : L iving ▁people ▁Category : American ▁bio chem ists ▁Category : Ch inese ▁em igr ants ▁to ▁the ▁United ▁States ▁Category : E du c ators ▁from ▁J ia x ing ▁Category : H ang z hou ▁University ▁al umn i ▁Category : Mac Ar thur ▁F ell ows