im id az oles u cc in oc ar box am ide ▁synth ase . ▁ ▁CA IR ▁+ ▁L - A sp art ate ▁+ ▁ATP ▁→ ▁SA IC AR ▁+ ▁AD P ▁+ ▁Pi ▁ ▁The ▁eight ▁is ▁catal yz ed ▁by ▁ad en yl os u cc inate ▁ly ase . ▁ ▁SA IC AR ▁→ ▁A IC AR ▁+ ▁F umar ate ▁ ▁The ▁products ▁A IC AR ▁and ▁f umar ate ▁move ▁on ▁to ▁two ▁different ▁path ways . ▁A IC AR ▁serves ▁as ▁the ▁react ant ▁for ▁the ▁nin th ▁step , ▁while ▁f umar ate ▁is ▁transport ed ▁to ▁the ▁cit ric ▁acid ▁cycle ▁which ▁can ▁then ▁skip ▁the ▁carbon ▁dio x ide ▁evolution ▁steps ▁to ▁produce ▁mal ate . ▁The ▁conversion ▁of ▁f umar ate ▁to ▁mal ate ▁is ▁catal yz ed ▁by ▁f umar ase . ▁In ▁this ▁way , ▁f umar ate ▁connect s ▁pur ine ▁synth esis ▁to ▁the ▁cit ric ▁acid ▁cycle . ▁ ▁The ▁nin th ▁is ▁catal yz ed ▁by ▁ph osph or ib os yl am ino im id az ole car box am ide ▁form yl trans fer ase . ▁ ▁A IC AR ▁+ ▁f TH F ▁→ ▁FA IC AR ▁+ ▁TH F ▁ ▁The ▁last ▁step ▁is ▁catal yz ed ▁by ▁In os ine ▁mon oph osph ate ▁synth ase . ▁ ▁FA IC AR ▁→ ▁I MP ▁+ ▁H 2 O ▁ ▁In ▁e uk ary otes ▁the ▁second , ▁third , ▁and