▁less er ▁amounts ▁in ▁the ▁colon , ▁kid ney ▁and ▁st om ach ▁along ▁with ▁the ▁non ▁edited ▁version . ▁Edit ing ▁is ▁also ▁development ally ▁reg ulated ▁with ▁the ▁non ▁edited ▁version ▁only ▁being ▁translated ▁early ▁in ▁development ▁but ▁the ▁edited ▁form ▁increases ▁during ▁development ▁in ▁the ▁t issues ▁where ▁editing ▁can ▁occur . ▁Edit ing ▁levels ▁of ▁A po B ▁m R NA ▁have ▁been ▁shown ▁to ▁vary ▁in ▁response ▁to ▁changes ▁in ▁di et . ▁expos ure ▁to ▁alco hol ▁and ▁h orm one ▁levels . ▁ ▁Conserv ation ▁ ▁A po B ▁m R NA ▁editing ▁also ▁occurs ▁in ▁m ice , ▁and ▁r ats . ▁In ▁contrast ▁to ▁humans ▁editing ▁occurs ▁in ▁li ver ▁in ▁m ice ▁and ▁r ats ▁up ▁to ▁a ▁frequency ▁of ▁ 6 5 %. ▁It ▁has ▁not ▁been ▁observed ▁in ▁birds ▁or ▁less er ▁species . ▁ ▁Con sequ ences ▁ ▁Str ucture ▁Edit ing ▁results ▁in ▁a ▁cod on ▁change ▁creating ▁an ▁in - frame ▁stop ▁cod on ▁leading ▁to ▁translation ▁of ▁a ▁trunc ated ▁protein , ▁A po B 4 8 . ▁This ▁stop ▁cod on ▁results ▁in ▁the ▁translation ▁of ▁a ▁protein ▁that ▁la cks ▁the ▁car box yl ▁termin us ▁which ▁contains ▁the ▁protein ' s ▁L DL R ▁binding ▁domain . ▁The ▁full ▁protein ▁A po B 1 0 0 ▁which ▁has ▁nearly ▁ 4 5 0 0 ▁am ino ▁ac ids ▁is ▁present ▁in ▁V LD L ▁and ▁L DL . ▁Since ▁many ▁parts ▁of ▁A po