ating ▁the ▁integrity ▁of ▁the ▁bio film ▁in ▁the ▁developing ▁and ▁m atur ation ▁phase . ▁L ys - ▁ging ip ains ▁( K g p ) ▁can ▁bind ▁to ▁imm obil ized ▁matrix ▁prote ins ▁f ibr in ogen ▁and ▁fib ron ect in ▁and ▁may ▁have ▁a ▁role ▁in ▁host ▁colon ization . ▁ ▁G ing ip ains ▁also ▁have ▁the ▁ability ▁to ▁deg rade ▁multiple ▁signals ▁of ▁the ▁host ▁imm une ▁response . ▁They ▁have ▁the ▁ability ▁to ▁cle ave ▁subclass ▁ 1 ▁and ▁ 3 ▁Ig G ▁ant ib od ies ▁as ▁well ▁as ▁pro infl am mat ory ▁cy tok ines ▁such ▁as ▁IL - 1 β , ▁IL - 2 , ▁IL - 6 , ▁T NF - α ▁and ▁IL - 8 ▁in ▁regions ▁of ▁high ▁P . ▁ging ival is ▁concentration , ▁imp air ing ▁host ▁imm une ▁response ▁function . ▁R g p ▁can ▁in hib it ▁IL - 2 ▁accum ulation ▁in ▁T - cell s , ▁which ▁enables ▁it ▁to ▁e va de ▁the ▁host ▁adapt ive ▁imm une ▁response , ▁by ▁mod ulating ▁T - cell ▁communication ▁and ▁pro l ifer ation . ▁ ▁G ing ip ains ▁are ▁key ▁factors ▁in ▁t issue ▁damage ▁sympt oms ▁of ▁period ont itis , ▁which ▁results ▁from ▁the ▁de grad ation ▁of ▁matrix ▁metal lo prote ins , ▁col lagen , ▁and ▁fib ron ect in . ▁D eg rad ation ▁of ▁these ▁substr ates ▁inter fer es ▁with ▁interactions ▁between ▁host ▁cells