▁kid ney , ▁and ▁low ▁levels ▁in ▁ske let al ▁mus cle , ▁li ver , ▁and ▁brain ▁t issue . ▁ ▁S 1 0 0 A 1 1 ▁is ▁imp licated ▁in ▁memb rane ▁and ▁c yt os ke let ar ▁dynamics , ▁ves icular ▁transport ation ▁and ▁processes ▁of ▁end o ▁and ▁ex oc yt osis . ▁It ▁has ▁been ▁shown ▁that ▁S 1 0 0 A 1 1 ▁interact s ▁with ▁many ▁c yt os ke let al ▁structures ▁as ▁tub ul in , ▁act in , ▁intermediate ▁fil aments ▁also ▁with ▁an nex in ▁I ▁and ▁an nex in ▁II . ▁S 1 0 0 A 1 1 ▁is ▁able ▁to ▁control ▁re organ ization ▁of ▁act in ▁and ▁it ▁is   important ▁in ▁forming ▁pro tr usion ▁by ▁met ast atic ▁cells . ▁▁ ▁It ▁la cks ▁en zym atic ▁activity , ▁it ▁functions ▁by ▁binding ▁to ▁other ▁prote ins , ▁it ▁regul ates ▁activity ▁of ▁other ▁en zym es . ▁It ▁is ▁associated ▁with ▁cell ▁cycle , ▁growth , ▁surv ival ▁and ▁apo pt osis . ▁It ▁has ▁been ▁identified ▁as ▁dual ▁growth ▁medi ator . ▁ ▁Supp ression ▁of ▁S 1 0 0 A 1 1 ▁by ▁small ▁inter fer ing ▁R NA ▁caused ▁cells ▁to ▁apo pt osis , ▁and ▁over expression ▁of ▁S 1 0 0 A 1 1 ▁has ▁been ▁found ▁to ▁in hib it ▁apo pt osis ▁in ▁tum or ▁cells . ▁Furthermore , ▁the ▁knock - down ▁of ▁S 1 0