▁was ▁about ▁an ▁aut os om al ▁re cess ive ▁form . ▁ 2 ▁related ▁patients ▁had ▁a ▁hom o zy g ous ▁miss ense ▁ST AT 1 ▁mut ation ▁which ▁caused ▁imp a ired ▁sp lic ing , ▁therefore ▁a ▁defect ▁in ▁m ature ▁protein . ▁Pat ients ▁had ▁partially ▁dam aged ▁response ▁to ▁both ▁IF Na ▁and ▁IF N g . ▁Scient ists ▁now ▁claim ▁that ▁re cess ive ▁ST AT 1 ▁def ic iency ▁is ▁a ▁new ▁form ▁of ▁primary ▁imm un ode fic iency ▁and ▁whenever ▁a ▁patient ▁suff ers ▁sudden , ▁severe ▁and ▁unexpected ▁b acter ial ▁and ▁vir al ▁in fe ctions , ▁should ▁be ▁considered ▁as ▁potentially ▁ST AT 1 ▁def ic ient ▁ ▁G ain ▁of ▁function ▁ ▁G ain ▁of ▁function ▁mut ation ▁was ▁first ▁discovered ▁in ▁patients ▁with ▁chron ic ▁m uc oc ut aneous ▁candid ias is ▁( C MC ). ▁This ▁disease ▁is ▁characteristic ▁with ▁its ▁sympt oms ▁as ▁persistent ▁in fe ctions ▁of ▁the ▁skin , ▁m uc osa e ▁- ▁or al ▁or ▁gen ital ▁and ▁n ails ▁in fe ctions ▁caused ▁by ▁Cand ida , ▁mostly ▁Cand ida ▁alb icans . ▁C MC ▁may ▁very ▁often ▁result ▁from ▁primary ▁imm un ode fic iency . ▁Pat ients ▁with ▁C MC ▁often ▁suffer ▁also ▁with ▁b acter ial ▁in fe ctions ▁( most ly ▁St ap hy loc oc cus ▁a ure us ), ▁also ▁with ▁in fe ctions ▁of ▁the ▁resp ir atory ▁system ▁and ▁skin . ▁In