▁both ▁his ▁personal ▁life ▁and ▁his ▁duties ▁as ▁Spider - Man , ▁which ▁affect s ▁his ▁civil ian ▁life ▁dram atically . ▁Meanwhile , ▁Dr . ▁Otto ▁Oct av ius ▁becomes ▁a ▁di abol ical ▁villa in ▁after ▁a ▁failed ▁experiment ▁k ills ▁his ▁wife ▁and ▁leaves ▁him ▁ne uro log ically ▁f used ▁to ▁mechanical ▁tent acles . ▁Spider - Man ▁must ▁stop ▁him ▁from ▁successfully ▁recre ating ▁the ▁dangerous ▁experiment , ▁while ▁dealing ▁with ▁a ▁sub cons cious ▁desire ▁to ▁stop ▁being ▁Spider - Man ▁that ▁is ▁stri pping ▁him ▁of ▁his ▁powers . ▁ ▁Ra imi ' s ▁insp iration ▁for ▁the ▁film ▁came ▁from ▁the ▁debut ▁of ▁Doctor ▁Oct opus ▁in ▁The ▁Ama zing ▁Spider - Man ▁# 3 ▁in ▁ 1 9 6 4 , ▁the ▁ 1 9 6 6 ▁story ▁arc ▁If ▁This ▁Be ▁My ▁Dest iny ... !, ▁and ▁the ▁ 1 9 6 7 ▁story ▁arc ▁Spider - Man ▁No ▁More !. ▁Princi pal ▁phot ography ▁began ▁in ▁April ▁ 2 0 0 3 ▁in ▁New ▁York ▁City ▁and ▁also ▁took ▁place ▁in ▁Los ▁Angeles . ▁Spider - Man ▁ 2 ▁was ▁released ▁in ▁both ▁conventional ▁and ▁I MAX ▁the aters ▁on ▁June ▁ 3 0 , ▁ 2 0 0 4 , ▁to ▁w ides p read ▁critical ▁acc laim ▁and ▁gross ed ▁$ 7 8 9 ▁million ▁world wide , ▁becoming ▁the ▁third ▁highest - g ross ing ▁film ▁of ▁the ▁year . ▁It ▁won ▁the ▁Academy ▁Award ▁for ▁Best ▁Visual ▁Effect