. ▁ ▁Gen etic ▁dis orders ▁High ▁levels ▁of ▁A po B ▁are ▁related ▁to ▁heart ▁disease . ▁Hyp ob etal ip op rote in emia ▁is ▁a ▁gen etic ▁dis order ▁that ▁can ▁be ▁caused ▁by ▁a ▁mut ation ▁in ▁the ▁A po B ▁gene , ▁AP OB . ▁Ab etal ip op rote ina emia ▁is ▁usually ▁caused ▁by ▁a ▁mut ation ▁in ▁the ▁M TP ▁gene , ▁M TP . ▁ ▁Mut ations ▁in ▁gene ▁AP OB 1 0 0 ▁can ▁also ▁cause ▁famil ial ▁hyper ch ol est ero lem ia , ▁a ▁her edit ary ▁( aut os om al ▁dominant ) ▁form ▁of ▁met abol ic ▁dis order ▁Hyper ch ol est ero lem ia . ▁ ▁Mouse ▁studies ▁Most ▁relevant ▁information ▁regarding ▁mouse ▁A po B ▁hom olog ue , ▁m A po B , ▁has ▁come ▁from ▁mouse ▁studies . ▁M ice ▁over express ing ▁m A po B ▁have ▁increased ▁levels ▁of ▁L DL ▁" bad ▁ch ol ester ol " ▁and ▁decre ased ▁levels ▁of ▁HD L ▁" good ▁ch ol ester ol ". ▁M ice ▁containing ▁only ▁one ▁functional ▁copy ▁of ▁the ▁m A po B ▁gene ▁show ▁the ▁opposite ▁effect , ▁being ▁resist ant ▁to ▁hyper ch ol est ero lem ia . ▁M ice ▁containing ▁no ▁functional ▁copies ▁of ▁the ▁gene ▁are ▁not ▁vi able . ▁ ▁M ole cular ▁bi ology ▁ ▁The ▁protein ▁occurs ▁in ▁the ▁pl asma ▁in ▁ 2 ▁main ▁is o forms , ▁A po