▁are ▁sh utt led ▁back ▁to ▁the ▁mit och ond ria ▁in ▁the ▁region ▁of ▁the ▁ad ren al ▁cor tex ▁within ▁which ▁synth esis ▁initially ▁began ▁and ▁it ▁is ▁there ▁that ▁synth esis ▁is ▁completed . ▁ ▁Path ology ▁ ▁C ushing ' s ▁Sy nd rome ▁C ushing ’ s ▁synd rome ▁ar ises ▁from ▁the ▁repeated ▁hyper secret ion ▁of ▁gl uc oc ort ico ids . ▁It ▁can ▁be ▁caused ▁by ▁either ▁an ▁ad ren al ▁tum or ▁or ▁by ▁hyper secret ion ▁of ▁ad ren oc ort ic otrop ic ▁h orm one ▁( ACT H ) ▁from ▁the ▁anterior ▁p itu it ary ▁g land . ▁It ▁is ▁pre domin antly ▁due ▁to ▁an ▁excess ▁of ▁the ▁gl uc oc ort ico id ▁cort is ol . ▁Secret ion ▁is ▁typically ▁reg ulated ▁by ▁the ▁hypoth al am us ▁which ▁secre tes ▁cort ic otrop in - re le asing ▁h orm one ▁( CR H ) ▁to ▁the ▁p itu it ary ▁g land , ▁stim ulating ▁the ▁p itu it ary ▁to ▁se crete ▁ad ren oc ort ic otrop ic ▁h orm one ▁( ACT H ). ▁A CT H ▁then ▁travel s ▁to ▁the ▁ad ren al ▁g lands ▁and ▁indu ces ▁the ▁release ▁of ▁cort is ol ▁into ▁the ▁blood stream . ▁In ▁C ushing ’ s ▁synd rome , ▁this ▁process ▁occurs ▁in ▁excess . ▁Some ▁sympt oms ▁of ▁an ▁individual ▁with ▁C ushing ’ s ▁synd rome ▁include ▁low ▁t