term inal ▁domain ▁or ▁SH 2 ▁domain . ▁Because ▁of ▁this ▁there ▁is ▁increased ▁ph osph ory lation ▁because ▁of ▁impossible ▁de ph osph ory lation ▁in ▁nucle us . ▁These ▁processes ▁are ▁dependent ▁on ▁cy tok ines ▁like ▁inter fer on ▁alpha ▁or ▁beta , ▁inter fer on ▁g amma ▁or ▁inter le uk in ▁ 2 7 . ▁As ▁mentioned ▁above , ▁low ▁levels ▁of ▁inter le uk in ▁ 1 7 A ▁were ▁observed , ▁therefore ▁imp a ired ▁the ▁Th 1 7 ▁polar ization ▁of ▁the ▁imm une ▁response . ▁ ▁Pat ients ▁with ▁ST AT 1 ▁gain ▁of ▁function ▁mut ation ▁and ▁C MC ▁poor ly ▁or ▁not ▁at ▁all ▁respond ▁to ▁treatment ▁with ▁az ole ▁dru gs ▁such ▁as ▁Fl u con az ole , ▁It ra con az ole ▁or ▁P osa con az ole . ▁Besides ▁common ▁vir al ▁and ▁b acter ial ▁in fe ctions , ▁these ▁patients ▁develop ▁auto imm un ities ▁or ▁even ▁car cin omas . ▁It ▁is ▁very ▁complicated ▁to ▁find ▁a ▁treatment ▁because ▁of ▁various ▁sympt oms ▁and ▁resist an cies , ▁in hib itors ▁of ▁J AK / STAT ▁path way ▁such ▁as ▁R ux olit in ib ▁are ▁being ▁tested ▁and ▁are ▁a ▁possible ▁choice ▁of ▁treatment ▁for ▁these ▁patients ▁ ▁Inter actions ▁ ▁ST AT 1 ▁has ▁been ▁shown ▁to ▁interact ▁with : ▁▁ ▁BR CA 1 , ▁▁ ▁C - j un , ▁▁ ▁CD 1 1 7 , ▁▁ ▁C RE B - binding