▁an ▁a za - C ope - M ann ich ▁reaction . ▁ ▁Giorg io ▁Ort ar ▁et ▁al . ▁expl ored ▁how ▁the ▁St ille - car b ony l ative ▁cross - cou pling ▁could ▁be ▁used ▁to ▁synth es ize ▁ben z oph en one ▁ph osph ores . ▁ ▁These ▁were ▁embedded ▁into ▁ 4 - ben zo yl - L - phen yl al an ine ▁pe pt ides ▁and ▁used ▁for ▁their ▁photo aff inity ▁lab elling ▁properties ▁to ▁explore ▁various ▁pe pt ide - prote in ▁interactions . ▁ ▁Louis ▁H eg ed us ' ▁ 1 6 - step ▁rac em ic ▁total ▁synth esis ▁of ▁J at raph one ▁involved ▁a ▁St ille - car b ony l ative ▁cross - cou pling ▁as ▁its ▁final ▁step ▁to ▁form ▁the ▁ 1 1 - member ed ▁macro cycle . ▁In ▁lieu ▁of ▁a ▁ha ilde , ▁a ▁vin yl ▁trif late ▁is ▁used ▁there ▁as ▁the ▁coupling ▁partner . ▁ ▁St ille - K elly ▁Cou pling ▁ ▁Using ▁the ▁sem inal ▁publication ▁by ▁E ab orn ▁in ▁ 1 9 7 6 , ▁which ▁forms ▁ar yl st ann anes ▁from ▁ar yl hal ides ▁and ▁dist ann anes , ▁T . ▁Ross ▁Kelly ▁applied ▁this ▁process ▁to ▁the ▁intr am ole cular ▁coupling ▁of ▁ar yl hal ides . ▁This ▁tan dem ▁st ann yl ation / ary l ▁hal ide ▁coupling ▁was ▁used ▁for ▁the ▁synth eses ▁of ▁a ▁variety ▁of