▁is ▁only ▁limited ▁and ▁poor - quality ▁information ▁available ▁regarding ▁the ▁effect iveness ▁of ▁o zone ▁ther apy ▁for ▁tre ating ▁foot ▁ul cers ▁in ▁people ▁with ▁di ab etes . ▁ ▁G row th ▁factors ▁- ▁there ▁is ▁some ▁low - quality ▁evidence ▁that ▁growth ▁factors ▁may ▁increase ▁the ▁lik elihood ▁that ▁di ab etic ▁foot ▁ul cers ▁will ▁he al ▁completely . ▁ ▁Cont inu ous ▁diffusion ▁of ▁o xygen ▁( C DO ) ▁- ▁C DO ▁del ivers ▁continuous ▁o xygen ▁to ▁an ▁occ l ud ed , ▁mo ist ▁w ound ▁site ▁at ▁much ▁lower ▁flow ▁rates ▁of ▁ 3 – 1 2 ▁m L / h ▁for ▁ 2 4 ▁h ▁ 7 ▁days ▁a ▁week ▁for ▁up ▁to ▁several ▁weeks ▁or ▁months , ▁depending ▁on ▁the ▁w ound ▁status . ▁ ▁Ep ide mi ology ▁Appro xim ately ▁ 1 5 ▁percent ▁of ▁people ▁with ▁di ab etes ▁experience ▁foot ▁ul cers . ▁And ▁approximately ▁ 8 4 ▁percent ▁of ▁lower ▁lim b ▁am put ations ▁have ▁a ▁history ▁of ▁ul cer ation ▁with ▁only ▁approximately ▁half ▁of ▁am put ees ▁surv iving ▁for ▁more ▁than ▁ 2 ▁years . ▁ 5 6 ▁percent ▁of ▁individuals ▁with ▁foot ▁ul cers ▁who ▁do ▁not ▁have ▁an ▁am put ations ▁surv ive ▁for ▁ 5 ▁years . ▁Foot ▁ul cers ▁and ▁am put ations ▁significantly ▁reduce ▁the ▁quality ▁of ▁life . ▁Appro xim ately ▁ 8 . 8 ▁percent ▁of ▁hospital ▁adm issions ▁of ▁di ab etic ▁patients ▁are