pe pt ide ▁m imet ics ▁P B DA - ▁and ▁u rea - based ▁in hib itors . ▁ ▁Other ▁potential ▁th era pe ut ic ▁applications ▁ ▁Ne urop ath ic ▁and ▁infl am mat ory ▁pain ▁▁ ▁P ain ▁cause ▁by ▁injury ▁to ▁C NS ▁or ▁P NS ▁has ▁been ▁associated ▁with ▁increase ▁gl ut am ate ▁concentration . ▁N AA G ▁in hib ition ▁reduced ▁gl ut am ate ▁presence ▁and ▁could , ▁thus , ▁dimin ish ▁pain . ▁( Ne ale ▁J H ▁et ▁al ., ▁ 2 0 0 5 ). ▁Nag el ▁et ▁al . ▁used ▁the ▁in hib itor ▁ 2 - P MP A ▁to ▁show ▁the ▁anal ges ic ▁effect ▁of ▁N AA G ▁pe pt id ase ▁in hib itions . ▁This ▁study ▁followed ▁one ▁by ▁Chen ▁et ▁al ., ▁which ▁showed ▁similar ▁results . ▁ ▁Head ▁injury ▁▁ ▁Se vere ▁head ▁injury ▁( SH I ) ▁and ▁tra um atic ▁brain ▁injury ▁( T BI ) ▁are ▁w ides p read ▁and ▁have ▁a ▁trem end ous ▁impact . ▁“ They ▁are ▁the ▁leading ▁cause ▁of ▁death ▁in ▁children ▁and ▁young ▁adult s ▁( < 2 5 ▁years ) ▁and ▁account ▁for ▁a ▁quarter ▁of ▁all ▁death s ▁in ▁the ▁five ▁to ▁ 1 5 ▁years ▁age ▁group ”. ▁Following ▁initial ▁impact , ▁gl ut am ate ▁levels ▁rise ▁and ▁cause ▁exc it ot ox ic ▁damage ▁in ▁a ▁process ▁that ▁has ▁been ▁well ▁character ized . ▁With ▁its ▁ability ▁to