ub le ▁e ct od om ain ▁is ▁the ▁cy tok ine ▁commonly ▁known ▁as ▁T NF - α , ▁which ▁is ▁of ▁p iv otal ▁importance ▁in ▁par ac r ine ▁signal ing . ▁This ▁prote ol yt ic ▁liber ation ▁of ▁sol ub le ▁T NF - α ▁is ▁catal yz ed ▁by ▁AD AM 1 7 . ▁ ▁Rec ently , ▁AD AM 1 7 ▁was ▁discovered ▁as ▁a ▁cru cial ▁medi ator ▁of ▁resistance ▁to ▁radi other apy . ▁Rad i other apy ▁can ▁indu ce ▁a ▁do se - dependent ▁increase ▁of ▁fur in - medi ated ▁cle av age ▁of ▁the ▁AD AM 1 7 ▁pro form ▁to ▁active ▁AD AM 1 7 , ▁which ▁results ▁in ▁en hanced ▁AD AM 1 7 ▁activity ▁in ▁vit ro ▁and ▁in ▁v ivo . ▁It ▁was ▁also ▁shown ▁that ▁radi other apy ▁activ ates ▁AD AM 1 7 ▁in ▁non - small ▁cell ▁lung ▁cancer , ▁which ▁results ▁in ▁shed ding ▁of ▁multiple ▁surv ival ▁factors , ▁growth ▁factor ▁path way ▁activation , ▁and ▁radi other apy - indu ced ▁treatment ▁resistance . ▁ ▁AD AM 1 7 ▁may ▁play ▁a ▁prominent ▁role ▁in ▁the ▁Not ch ▁signal ing ▁path way , ▁during ▁the ▁prote ol yt ic ▁release ▁of ▁the ▁Not ch ▁int rac ell ular ▁domain ▁( from ▁the ▁Not ch 1 ▁re ceptor ) ▁that ▁occurs ▁following ▁lig and ▁binding . ▁▁ ▁AD AM 1 7 ▁also ▁regul ates ▁the ▁M AP ▁kin ase ▁signal ing