I've used Acronis TrueImage since version 3, I switched to it because I grew tired of all the hoops you needed to jump through to use Ghost, and TrueImage offered a more "modern" approach to backup — they actually built a bootable disk AUTOMATICALLY.
Ghost has come a long way since that time, but so has TrueImage.
Why would you want TrueImage?
Well, it works, and it works well — and it's affordable ($49.99 or $29.99 for an upgrade).
TrueImage has lots of features, but nine times out of ten the ones I care most about is creating an image of a disk and restoring it; or creating a clone of a disk. TrueImage has excellent support for network adapters and disk channels when you boot it from the rescue media and since you can run it under Windows it will support anything Windows can access.
Previous versions of TrueImage all worked great… so why did I upgrade to v12 aka 2009? Simple, AHCI support — that's Advanced Host Controller Interface, it's the mode you want to run your SATA controller and discs in if your operating system supports it (which Vista does).
Aside from including AHCI support in the new version, Acronis changed the user interface — according to them to be more Vista like; I say they just changed it.
The Acronis user interface is useable, but I would say that it's never been as clear as it should be. In my mind they should have sat down in a focus group with some users and hammered out the details of making it present better and clearer information. As long as you pay attention and read what's on the screen and don't continue if you're not sure you'll be fine… it works fine and the information is there (it's just not as clear as you might want).
I definitely recommend Acronis TrueImage (and all the Acronis products I've tried are fine). I do, however, have to gripes that I'll share.
First, TrueImage basically has most of the functions of Disk Director included in it, so why not just expose them so that they are easy to use.
Second, Acronis has too many products! In fact, when I wanted to upgrade my copy of TrueImage I almost just threw my hands up and left when it wasn't easy to find the product I wanted (and I even knew the name of it). Why? Why so many different products that do almost the same thing? Wouldn't it be far simpler to have fewer base products and sell option packs (keys) to enable advanced features?
Acronis does a great job of keeping their products up-to-date with patches, and they have a fairly nice web interface to their customer registration system (keeps your previous purchases since version 6 I think in one place along with the serial numbers).
One thing to keep in mind, Vista has some of the capabilities of TrueImage (backup and partition re-size), but not all of them… you may be quite happy with what you already have, or you may want a more complete solution.
If you're not sure what Acronis can do for you, checkout their web site, and you can even try their trial version (it is crippled unfortunately, but if it weren't people would just use the trial and never buy).