The module will focus on understanding the mechanisms underlying complex brain disorders and injury. Topic covered will include an integrated view of the major neurotransmitter systems and in-depth analysis of the mechanisms underlying the effects of drugs used in central nervous system. Neuronal pathways using excitatory and inhibitory amino acids and neuropeptides will be reviewed, with emphasis on their involvement in neuropathological processes underlying disorders such as Parkinson's disease, dementia, schizophrenia, mood disorders, pain, head injury, stroke, epilepsy and drug abuse.