London: England manager Gareth Southgate expressed his support for Declan Rice after the West Ham midfielder apologised on Thursday for old social media posts that appeared to express support for the IRA.
Rashford's absence means that one of 18-year-old pair Jadon Sancho or Callum Hudson-Odoi is likely to start alongside Harry Kane and Raheem Sterling in attack.
Hudson-Odoi is yet to start a Premier League game for Chelsea and was only called into the senior squad on Monday due to injuries.
But Southgate insists he has the faith in the winger's talent that Maurizio Sarri often has not at Stamford Bridge this season.
"Jadon has had more big match experience at this point, but Callum has fitted in brilliantly. I wouldn't hesitate to start either of them, they are ready. They can play for us," he added.
"Ideally you would have them all playing regularly and ideally they would all have a certain number of games for their clubs, but I can't wait for that.
"I can't wait for clubs to pick players 50, 100 times. That is not the landscape we are operating in.
"What we have seen in different positions is players we think are good enough so we'll play them. Callum has fitted in, he looks every inch an England international in training and I wouldn't hesitate to start him."