{"most_severe_consequence": "missense_variant", "transcript_consequences": [{"biotype": "protein_coding", "gene_symbol_source": "HGNC", "protein_end": 3457, "gene_symbol": "APOB", "cds_end": 10370, "cadd_phred": 22.9, "canonical": 1, "phylop100way_vertebrate": 0.014, "strand": -1, "codons": "tCc/tGc", "amino_acids": "S/C", "transcript_id": "ENST00000233242", "gene_id": "ENSG00000084674", "consequence_terms": ["missense_variant"], "protein_start": 3457, "impact": "MODERATE", "cds_start": 10370, "polyphen_prediction": "possibly_damaging", "sift_prediction": "deleterious", "gerp++_rs": 3.94, "hgnc_id": 603, "cdna_start": 10498, "sift_score": 0.02, "cdna_end": 10498, "cadd_raw": 2.631384, "variant_allele": "C", "polyphen_score": 0.865}], "input": "2:g.21229370G>C", "allele_string": "G/C", "id": "2:g.21229370G>C", "colocated_variants": [{"clin_sig_allele": "C:uncertain_significance", "end": 21229370, "allele_string": "G/C", "phenotype_or_disease": 1, "start": 21229370, "clin_sig": ["uncertain_significance"], "id": "rs778985735", "strand": 1, "frequencies": {"C": {"gnomad_asj": 0, "gnomad_oth": 0, "gnomad_nfe": 5.304e-05, "gnomad_afr": 0, "gnomad_fin": 0, "gnomad_sas": 0, "gnomad": 2.393e-05, "gnomad_amr": 0, "gnomad_eas": 0}}}, {"start": 21229370, "end": 21229370, "id": "CM159893", "strand": 1, "allele_string": "HGMD_MUTATION", "phenotype_or_disease": 1}], "strand": 1, "end": 21229370, "seq_region_name": "2", "assembly_name": "GRCh37", "start": 21229370}