{"seq_region_name": "1", "end": 55524250, "assembly_name": "GRCh37", "start": 55524250, "most_severe_consequence": "missense_variant", "colocated_variants": [{"id": "rs1430200092", "strand": 1, "allele_string": "C/T", "end": 55524250, "start": 55524250}], "strand": 1, "id": "1:g.55524250C>T", "input": "1:g.55524250C>T", "transcript_consequences": [{"gene_symbol": "PCSK9", "protein_end": 478, "cadd_phred": 10.8, "cds_end": 1433, "biotype": "protein_coding", "gene_symbol_source": "HGNC", "canonical": 1, "phylop100way_vertebrate": 1.795, "codons": "gCc/gTc", "amino_acids": "A/V", "strand": 1, "consequence_terms": ["missense_variant"], "gene_id": "ENSG00000169174", "transcript_id": "ENST00000302118", "cds_start": 1433, "polyphen_prediction": "benign", "sift_prediction": "tolerated", "gerp++_rs": 2.44, "impact": "MODERATE", "protein_start": 478, "hgnc_id": 20001, "sift_score": 0.25, "cdna_end": 1723, "cdna_start": 1723, "polyphen_score": 0.034, "cadd_raw": 0.66386, "variant_allele": "T"}, {"strand": 1, "cdna_start": 2157, "cdna_end": 2157, "variant_allele": "T", "transcript_id": "ENST00000490692", "cadd_raw": 0.66386, "gene_id": "ENSG00000169174", "consequence_terms": ["non_coding_transcript_exon_variant"], "impact": "MODIFIER", "gene_symbol_source": "HGNC", "biotype": "processed_transcript", "cadd_phred": 10.8, "gene_symbol": "PCSK9", "hgnc_id": 20001}, {"codons": "Ccc/Tcc", "amino_acids": "P/S", "strand": 1, "consequence_terms": ["missense_variant"], "gene_id": "ENSG00000169174", "transcript_id": "ENST00000543384", "protein_end": 261, "gene_symbol": "PCSK9", "cds_end": 781, "cadd_phred": 10.8, "biotype": "protein_coding", "gene_symbol_source": "HGNC", "phylop100way_vertebrate": 1.795, "sift_score": 0, "cdna_end": 1040, "cdna_start": 1040, "polyphen_score": 0, "cadd_raw": 0.66386, "variant_allele": "T", "cds_start": 781, "polyphen_prediction": "unknown", "sift_prediction": "deleterious_low_confidence", "gerp++_rs": 2.44, "protein_start": 261, "impact": "MODERATE", "hgnc_id": 20001}], "allele_string": "C/T"}