[
  {
    "comment": "2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699), subsequently R03270 TPP-dependent enzymatic reaction (see R00006), subsequently R03050 TPP-dependent enzymatic reaction (see R00226), subsequently R04672 TPP-dependent enzymatic reaction (see R00224), subsequently R00755 TPP-dependent enzymatic reaction (see R08648), subsequently R04673", 
    "definition": "Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2", 
    "orthologs": {
      "K11258": "acetolactate synthase II small subunit [EC:2.2.1.6]", 
      "K00161": "pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]", 
      "K00162": "pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]", 
      "K00163": "pyruvate dehydrogenase E1 component [EC:1.2.4.1]", 
      "K01568": "pyruvate decarboxylase [EC:4.1.1.1]", 
      "K01653": "acetolactate synthase I/III small subunit [EC:2.2.1.6]", 
      "K01652": "acetolactate synthase I/II/III large subunit [EC:2.2.1.6]"
    }, 
    "name": "pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)", 
    "product_stoichiometries": [
      "1", 
      "1"
    ], 
    "enzymes": [
      "1.2.4.1", 
      "2.2.1.6", 
      "4.1.1.1"
    ], 
    "equation": "C00022 + C00068 <=> C05125 + C00011", 
    "glycans": false, 
    "substrate_stoichiometries": [
      "1", 
      "1"
    ], 
    "rpairs": {}, 
    "entry_id": "R00014", 
    "pathways": {
      "rn01130": "Biosynthesis of antibiotics", 
      "rn01120": "Microbial metabolism in diverse environments", 
      "rn01110": "Biosynthesis of secondary metabolites", 
      "rn00620": "Pyruvate metabolism", 
      "rn00020": "Citrate cycle (TCA cycle)", 
      "rn00010": "Glycolysis / Gluconeogenesis"
    }, 
    "products": [
      "C05125", 
      "C00011"
    ], 
    "substrates": [
      "C00022", 
      "C00068"
    ]
  }
]