evidence: Amid ongoing misinformation about COVID-19 vaccinations and blood donation, America’s Blood Centers, the Association for the Advancement of Blood & Biotherapies (AABB), and the American Red Cross reiterate the safety of America’s blood supply and assure the public that vaccines do not pose a risk to patients receiving blood transfusions. Blood donations from individuals who have received a COVID-19 vaccine approved or authorized for use in the U.S. are safe for transfusion. Similar to other vaccines such as those for measles, mumps or influenza, COVID-19 vaccines are designed to generate an immune response to help protect an individual from illness, but vaccine components themselves do not replicate through blood transfusions or alter a blood recipients’ DNA. In summary, there is no scientific evidence that demonstrates adverse outcomes from the transfusions of blood products collected from vaccinated donors and, therefore, no medical reason to distinguish or separate blood donations from individuals who have received a COVID-19 vaccination.