evidence: CN112220919A - Nano coronavirus recombinant vaccine taking graphene oxide as carrier - Google Patents [...] The invention belongs to the field of nano materials and biomedicine, and relates to a vaccine, in particular to development of 2019-nCoV coronavirus nuclear recombinant nano vaccine. The invention also comprises a preparation method of the vaccine and application of the vaccine in animal experiments. The new corona vaccine contains graphene oxide, carnosine, CpG and new corona virus RBD; binding carnosine, CpG and neocoronavirus RBD on the backbone of graphene oxide; the CpG coding sequence is shown as SEQ ID NO 1; the novel coronavirus RBD refers to a novel coronavirus protein receptor binding region which can generate a high-titer specific antibody aiming at the RBD in a mouse body, and provides a strong support for prevention and treatment of the novel coronavirus. [...] 1. A coronavirus vaccine, wherein said coronavirus comprises graphene oxide, carnosine, CpG, and a novel coronavirus receptor binding domain; binding carnosine, CpG, and a novel coronavirus receptor binding region on a backbone of graphene oxide; the CpG coding sequence is shown as SEQ ID NO 1; the novel coronavirus receptor binding region refers to a novel coronavirus S protein receptor binding region.