evidence: Researchers link new gene variant in Amish population to lower risk of heart disease [...] University of Maryland School of Medicine (UMSOM) researchers, working with scientists from the Regeneron Genetics Center (RGC), discovered a new gene variant associated with lower levels of heart-damaging LDL cholesterol and a blood clotting protein called fibrinogen that appears to significantly lower a person's risk of heart disease. While the gene variant is extremely rare in the general population (less than 1 in 10,000), it is found in about 12 percent of those living in the Lancaster county, Pennsylvania Amish community, according to the study published today in the journal Science.