evidence: This report found a disproportionately high percentage of cancer deaths with COVID-19 as the underlying cause among Hispanic, AI/AN, and Black persons compared with the percentage in other racial and ethnic groups. Similar disparities have been observed for COVID-19 mortality (8) as well as cancer mortality (9). Health inequities are driven, in part, by structural racism, discrimination, stigma, and longstanding disenfranchisement (10). CDC is collaborating with local, state, tribal, and national partners to address environmental, place-based, occupational, policy, and systemic factors that affect health outcomes.§§§ For example, national cancer programs funded by CDC are required to include activities to identify drivers of cancer health disparities and address inequities in populations disproportionately affected by the increased risk for cancer or by the lack of adequate health care options for prevention or treatment.¶¶¶ Disproportionately affected populations can be defined by sex, race, religion, ethnicity, culture, disability, sexual orientation, gender identity, geographic location, socioeconomic status, insurance status, literacy level, or the intersection of several of these factors that collectively affect health outcomes. [...] This report found disproportionately higher percentage of cancer deaths with COVID-19 as the underlying cause of death among persons who were older; male; categorized as Hispanic, AI/AN, and Black; or living with certain cancers, such as leukemia, lymphoma, and myeloma. These results could guide multicomponent COVID-19 prevention interventions and ongoing, cross-cutting efforts to reduce health disparities and address structural and social determinants of health among cancer survivors, which might help protect those at disproportionately increased risk for dying from COVID-19.