evidence: Professor Daniel O'Connor, Head of Bioinformatics at the Oxford Vaccine Group (OVG), led the study. He said: 'These results confirm the efficacy of vaccination and its pivotal role in reducing the harmful consequences associated with COVID-19. The results of our research highlight the ChAdOx1 nCoV-19 vaccine's ability to modulate harmful responses to the SARS-CoV-2 virus, and therefore to reduce the severity of illness. The implications of these findings are far-reaching, offering evidence that is fundamental to future vaccine development and pandemic mitigation strategies. It also provides valuable guidance for policymakers and public health experts.' Professor Sir Andrew Pollard, Ashall Professor of Infection and Immunity and Director of the Oxford Vaccine Group, said: 'Better understanding of how vaccines can reduce the severity of infections caused by viruses like COVID-19 is a key part of our preparedness to make effective vaccines against the next pandemic threat. Ongoing research is critical as we know the next one is coming but we don’t know which virus or when it will be.' [...] - Demonstrated reduction in harmful responses associated with COVID-19 severity in recipients of the ChAdOx1 nCoV-19 vaccine compared with unvaccinated counterparts.