evidence: The 2024–25 COVID-19 vaccine is updated to better protect against variants that are currently spreading. This respiratory virus season, only one shot of the vaccine is needed for most people, and there are no boosters. (People who are immunocompromised or ages 6 months to 4 years may need more than one dose of the 2024–25 vaccine.) How is the 2024–25 COVID-19 vaccine different from previous COVID-19 vaccines? [...] Because the 2024–25 COVID vaccine is effective for recent viral strains, it is recommended that everyone stay up to date by getting this vaccine. Previous vaccines or boosters were not developed to target the more recent strains. For 2024–25, the CDC recommends: