evidence: Both the DNA and RNA vaccines can produce B and T cell-mediated immunity, though they have different conveniences. DNA vaccines have a risk of integrating the DNA with host DNA, whereas RNA vaccines have no such type of risk. Moreover, RNA vaccines require more cold storage temperature than DNA vaccines [55]. There are ten COVID-19 vaccine candidates in the clinical, and 11 candidates are in the preclinical evaluation stage as of 13 August 2021, which are developed using the DNA platform [83]. On the other hand, three COVID-19 vaccine candidates have been employed as an emergency vaccine, and 34 more vaccine candidates in the clinical and preclinical evaluation stage developed using the RNA platform [84]. BNT162b2 (97 countries), mRNA-1273 (65 countries), and TAK-919 (Japan) are mRNA based vaccines that have been using worldwide as authorized vaccines for COVID-19 [34]. [...] Lamb YN. BNT162b2 mRNA COVID-19 vaccine: first approval. Drugs. 2021;81:495–501. https://doi.org/10.1007/s40265-021-01480-7.