evidence: WHO published a Scientific Brief on the off-label use of medicines for COVID-19, addressing the issue of compassionate use. [...] WHO announced that the hydroxychloroquine arm of the Solidarity Trial to find an effective COVID-19 treatment was being stopped. The decision was based on large scale randomized evidence from the Solidarity, Discovery and Recovery trials, as well as a review of available published evidence from other sources, which showed that hydroxychloroquine did not reduce mortality for hospitalised COVID-19 patients. [...] WHO published a guideline on therapeutics and COVID-19, with new information for clinicians including a conditional recommendation against the use of remdesivir in hospitalized patients with COVID-19, regardless of disease severity.