evidence: On October 22, 2021, this report was posted online as an MMWR Early Release. [...] VSD, a collaborative project between CDC’s Immunization Safety Office and nine health care organizations, collects electronic health data, including information on vaccines, for specific studies. In this cohort study of VSD members aged ≥12 years, vaccination status through May 31, 2021 was determined. Index dates were assigned to all persons on the basis of the distribution of vaccination dates among vaccinated persons.¶ Person-time for unvaccinated persons included unvaccinated person-time before COVID-19 vaccination among COVID-19 vaccinees, and unvaccinated person-time of persons who did not receive a COVID-19 vaccine by May 31, 2021. To ensure comparable health care–seeking behavior among persons who received a COVID-19 vaccine and those who did not (unvaccinated persons), eligible unvaccinated persons were selected from among those who received ≥1 dose of influenza vaccine in the last 2 years. Separate unvaccinated groups were selected for mRNA and Janssen vaccines.** Deaths were identified through VSD, which captures hospital deaths and deaths reported to health plans. In this study, non–COVID-19 deaths were assessed because a protective effect of COVID-19 vaccination for COVID-19–related deaths was expected. [...] Suggested citation for this article: Xu S, Huang R, Sy LS, et al. COVID-19 Vaccination and Non–COVID-19 Mortality Risk — Seven Integrated Health Care Organizations, United States, December 14, 2020–July 31, 2021. MMWR Morb Mortal Wkly Rep 2021;70:1520–1524. DOI: http://dx.doi.org/10.15585/mmwr.mm7043e2.