evidence: Measles continues to pose a relentlessly increasing threat to children. In 2022, 37 countries experienced large or disruptive measles outbreaks compared with 22 countries in 2021. Of the countries experiencing outbreaks, 28 were in the WHO Region for Africa, six in the Eastern Mediterranean, two in the South-East Asia, and one in the European Region. "The increase in measles outbreaks and deaths is staggering, but unfortunately, not unexpected given the declining vaccination rates we’ve seen in the past few years," said John Vertefeuille, director of CDC’s Global Immunization Division. "Measles cases anywhere pose a risk to all countries and communities where people are under-vaccinated. Urgent, targeted efforts are critical to prevent measles disease and deaths." [...] CDC and WHO urge countries to find and vaccinate all children against measles and other vaccine-preventable diseases, and encourage global stakeholders to aid countries to vaccinate their most vulnerable communities. In addition, to help prevent outbreaks, all global health partners at the global, regional, national, and local levels must invest in robust surveillance systems and outbreak response capacity to rapidly detect and respond to outbreaks.