evidence: The association was supported in further stratified Mendelian randomization analyses, which confirmed an inverse association between serum 25(OH)D in the deficiency range and CRP, but not with higher concentrations of serum vitamin D. [...] However, the nonlinear Mendelian randomization approach used in the current study allows for better detection of the association, and the authors point out that the method has also been recently used in research showing an adverse effect of vitamin D deficiency on cardiovascular disease (CVD) risk and mortality, which would not be visible using the standard linear Mendelian randomization approach. [...] Cite this: Vitamin D Deficiency Clearly Linked to Inflammation - Medscape - Aug 19, 2022.