evidence: The SARS CoV-2 spike protein, either originating from the virus or coded within the cells from the synthetic mRNAs, is distributed throughout the immune system via exosomes to manifest as disease symptoms, especially towards causing cardiological diseases, including myocarditis, pericarditis, peri-myocarditis and myocardial infarction.15–17 The similarities between the pathophysiological mechanisms causing disease in long COVID and mRNA vaccination injuries are described briefly in later sections in relation to the plausible therapeutic activities of lutein. [...] In this regard, a related in silico docking study46 points to lutein’s synergistic interaction with another phenolic compound, quercetin. The study predicts that, by binding to different spike protein structural locations, the combination of quercetin and lutein can enhance the destabilization of spike on the ACE2 interface. Moreover, it has been shown that quercetin exerts anti-COVID-19 activity by inhibiting the expression of ACE2 receptors.141 Curcumin, another highly lipophilic phytochemical, was shown in an in silico study to also have potentially inhibitory properties against the spike protein of the new SARS-CoV-2 variants.142 Curcumin can thus act synergistically with lutein. Quercetin, curcumin, and lutein all have anti-inflammatory properties that prompted this investigation into potential synergistic activities against post-COVID and mRNA vaccination injuries. Moreover, quercetin and curcumin have been considered as natural potential therapeutic agents against SARS-CoV-2 infection.141,143 In addition, bromelain, another naturally derived potent anti-inflammatory and proteolytic molecule, can be used synergistically with the aforementioned compounds to enhance the anti-inflammatory response.144 Finally, the fibrinolytic enzyme nattokinase can be used in conjunction with lutein, as it has recently been shown to effectively degrade the spike protein of SARS-CoV-2.145