evidence: Increased Hospitalizations Involving Fungal Infections during COVID-19 Pandemic, United States, January 2020–December 2021 Hospitalizations involving fungal infections increased 8.5% each year in the United States during 2019–2021. During 2020–2021, patients hospitalized with COVID-19–associated fungal infections had higher (48.5%) in-hospital mortality rates than those with non–COVID-19–associated fungal infections (12.3%). Improved fungal disease surveillance is needed, particularly during respiratory virus pandemics. [...] During 2019–2021, a total of 59,212 fungal hospitalizations were identified in the PHD-SR. Rates of fungal hospitalizations (per 10,000 hospitalizations) increased from 22.3 in 2019 to 25.0 in 2020 and 26.8 in 2021 (p<0.01), representing an average annual percentage change of 8.5% (Table 1). Average annual rates of hospitalization significantly increased for each fungal infection, except for those caused by Pneumocystis spp., Cryptococcus spp., and other specified fungi (Table 1).