evidence: Self-reported use of ivermectin or hydroxychloroquine, endorsing false statements related to COVID-19 vaccination, self-reported trust in various institutions, conspiratorial thinking measured by the American Conspiracy Thinking Scale, and news sources. [...] The antiparasitic agents ivermectin and hydroxychloroquine were both touted as cures for the SARS-CoV-2 virus, in the absence of evidence of efficacy. Despite multiple US Food and Drug Administration (FDA) statements clarifying that these medicines are not indicated for COVID-19,1 prescribing increased substantially in the US, Canada, and Australia in the first year of the pandemic2-4; 1 study3 showed an association between prescribing and county-level support for Donald Trump. Beyond a lack of efficacy, such prescriptions were associated with risk of toxic effects.5 Their use thus introduced inefficiencies and expense as well as potential adverse effects on health and may help explain the observed association between more misinformation-prone counties and greater COVID-19 death rates.6 [...] PA. Hydroxychloroquine for COVID-19: variation in regional political preferences predicted new prescriptions after President Trump’s endorsement.