evidence: Nicotine may relieve symptoms of Parkinson's disease - PMID: 7862924 - DOI: 10.1007/BF02244882 Nicotine may relieve symptoms of Parkinson's disease Two elderly patients with Parkinson's disease were treated with nicotine gum and patch. Reliable changes in symptomatology were noted, using a single-subject, placebo-control reversal design. Improvement was associated with active nicotine dosing and involved diminished tremor and disorganized thinking in one patient and diminished bradykinesia and increased energy in the other.