evidence: Beyond rhinosinusitis, two clinical trials have assessed the use of silver colloids in the topical treatment of bacterial infections. In a study completed (NCT02761525) at the Universidad Autónoma de San Luis Potosí (Mexico), AgNPs were explored for treating oral pathogens in patients intubated with mechanical ventilators. The study determined that gels containing 12 ppm of 24-nm AgNPs (produced in house) and applied in the oral mucosa surface of mechanically ventilated patients could reduce up to 9-fold the formation of pathogenic microbial colonies in comparison to the same gel without silver colloids [41]. In a second phase-I study (NCT03752424) at the Al-Azhar University (Egypt), a vanishing cream containing AgNPs is being explored to treat dermal bacterial and fungal infections. [...] Politano AD, Campbell KT, Rosenberger LH, Sawyer RG. Use of Silver in the Prevention and Treatment of Infections. Silver Rev Surg Infections. 2013;14:8–20.