evidence: Leuprolide injection comes as a long-acting suspension that is injected intramuscularly (into a muscle) by a doctor or nurse in a medical office or clinic and is usually given once a month or every 1, 3, 4, or 6 months depending on the product chosen for you (Lupron Depot-PED, Lupron Depot, leuprolide acetate for suspension). Leuprolide injection also comes as a long-acting suspension that is injected subcutaneously (just under the skin) by a doctor or nurse in a medical office or clinic and is usually given every 1, 3, 4, or 6 months depending on the product chosen for you (Camcevi, Eligard, Fensolvi). Your doctor will tell you how long your treatment with leuprolide injection will last. When used in children with precocious puberty, leuprolide injection (Lupron Depot-PED, Lupron Depot-PED-3 month, Fensolvi) will likely be stopped by your child's doctor before 11 years of age in girls and 12 years of age in boys. [...] In children receiving leuprolide injection for precocious puberty, new or worsening symptoms of sexual development may occur during the first few weeks of treatment. In girls receiving leuprolide injection for precocious puberty, the onset of menstruation or spotting (light vaginal bleeding) may occur during the first two months of treatment. If bleeding continues beyond the second month, call your doctor.