evidence: 1Institut National de la Santé et de la Recherche Médicale (INSERM) U1151, Paris, France, 2Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark, 3Institut National de la Santé et de la Recherche Médicale (INSERM) U1173, Montigny le Bretonneux, France. [...] Supported by: No.115797-INNODIA and No.945268 INNODIA HARVEST [...] Supported by: RSSDI,RSSDI WB,WBDST,ICMR