evidence: The United States Centers for Disease Control and Prevention (CDC) has data on drug overdose death rates and totals. Around 1,106,900 US residents died from drug overdoses from 1968 to 2020. Around 932,400 died from 1999 through 2020. Around 93,700 died in 2020. Opioids were involved in around 80,400 of the around 109,200 deaths in 2021. Synthetic opioids other than methadone (primarily fentanyl) were involved with 70,601 deaths in 2021. Around 111,000 people died in 2022. Around 108,300 in 2023.[4][5][6][1][2] [...] Opioid charts [edit]Opioids were involved in around 80,400 of the around 106,700 deaths in 2021.[7] See map higher up for states with the highest overdose death rates. Rate timeline by race and ethnicity [edit]Rate timeline by sex [edit]Comparisons to other countries in Europe [edit]There were around 68,700 drug overdose deaths in the United States in 2018. That is a rate of 210 deaths per million residents.[4][5] Compare that rate to the 2018 rates of the European countries in the first chart below.