evidence: We will describe two of them in more detail here, both related to preventing transmission of infection through air. [...] We thank HICPAC for taking on the challenging task of updating our nation’s infection control isolation guidelines. The COVID-19 pandemic will not be the last one we face. We must be better prepared for the next pandemic and use what we have learned to improve approaches to preventing transmission of any pathogen spread through air in healthcare settings. The multi-year effort to update the isolation precautions guideline is a critical part of achieving that goal.