evidence: We also discovered a significant increase in post-vaccination COVID-19 cases among individuals previously infected with COVID-19. Such findings may raise the issue of the benefit of vaccines for people who were previously infected with SARS-CoV-2. It is noteworthy that a study conducted in Kentucky (May–June 2021), reported an odds ratio of 2.34 (95% CI 1.58–3.47) of re-infection among unvaccinated participants compared to those who were fully vaccinated, suggesting that full vaccinations after a past SARS-CoV-2 infection provide additional protection by decreasing its transmissibility by shortening the duration of infectivity and so decrease the transmissibility77. Therefore, vaccination should be offered to all eligible individuals regardless of their previous infection status. While there is limited epidemiological evidence supporting the benefits of vaccination for previously infected individuals, our study supports the notion. [...] Stamatatos, L. et al. mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection. Science372, 1413–1418 (2021). [...] Centers for Disease Control and Prevention (CDC). Myocarditis and Pericarditis After mRNA COVID-19 Vaccination. Centers for Disease Control and Preventionhttps://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/myocarditis.html (2020).