evidence: In fact, AIDS Map reports animal models show that while poppers can cause transient immunosuppression (where it may be suppressed for a short period of time), they are not linked to long-term immunosuppression in gay men with HIV or to the development of Kaposi’s sarcoma, the most common AIDS-defining cancer. [...] One particular study by the Multicenter AIDS Cohort Study investigated the relationship between the use of poppers and cancer. Researchers divided 3,223 male participants (1,563 of whom were HIV-positive, and 1,660 of whom were not) into three groups: heavy users, light users, and non-users. [...] Of course, many remember the popularity and hysteria over poppers in the 1980s: During the early days of the AIDS epidemic when poppers were thought to be the cause of the disease that was then called "gay cancer." Now we know it's HIV. It's a reminder that initial studies need to be augmented, and in this case to determine causal links between poppers and cancer in HIV-negative men.