evidence: To enhance public acceptance of COVID-19 vaccines and establish trust in vaccine safety and understand potential adverse effects, clear and reliable information is essential. The National Institutes of Health (NIH) urged further research on the effects of COVID-19 vaccines12. Despite the WHO's call for high-quality research on the negative health, social, and economic effects of COVID-19 vaccines, conclusive evidence is still lacking, necessitating further investigation into the factors contributing to these effects2,11,23. Many observational studies were conducted to monitor or detect the AEs following COVID-19 vaccinations with a wide range of AE rates between 13 and 90%12,24,25,26,27,28,29,30,31,32,33. Fewer studies focusing only on one country, one province, or one area were performed in the Arab countries with most studies done in Saudi Arabia and Egypt33,34,35,36,37,38,39,40,41. Hence, this multicenter study aimed to explore the AEs of different types and doses of COVID-19 vaccines and identify associated factors among vaccinated participants in six Arabic countries.