evidence: Males continued to account for three-quarters of suicide deaths registered in 2021 (4,129 male deaths compared with 1,454 female deaths), as seen since the mid-1990s. In 2021, the suicide ASMR for males in England and Wales was 16.0 deaths per 100,000; consistent with rates between 2018 and 2020. [...] By English region, the highest ASMR was in the North East (14.1 deaths per 100,000 people), which is the case in 6 out of the last 10 preceding years. The North East, North West, Yorkshire and The Humber and the South West regions had statistically significantly higher ASMRs of suicide compared with the overall England ASMR (10.5 per 100,000). The lowest rate in 2021 was in London (6.6 deaths per 100,000 people), which was statistically lower than any English region. The lowest London rate, since records started in 1981, occurred in 2021 and was statistically lower than the London rate in 2018 and 2019. [...] Scotland and Northern Ireland each produce their own suicide statistics. These statistics are compiled by National Records of Scotland (NRS) and the Northern Ireland Statistics and Research Agency (NISRA), and are comparable with those in this bulletin. The Office for Health Improvement and Disparities (OHID) provide data, via their Suicide Prevention Profiles, on a wide range of indicators related to suicide, including mortality and years of life lost due to suicide.