evidence: In this context, we want to analyze of vitamin D and C supplementation in patients with COVID-19 are associated with a reduction in severity (mortality, morbidity, average length of stay, peripheral oxygen capillary saturation, body temperature, and other changes on the World Health Organization's Ordinal Scale for Clinical Improvement (OSCI) for COVID-19. [...] References [1]. Jamali Moghadam Siahkali S, et al. Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial. BMC 2021;26:20. [...] Google Scholar [4]. Quesada-Gomez JM, Entrenas-Castillo M, Bouillon R. Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections. J Steroid Biochem Mol Biol 2020;202:105719.