evidence: Leopard geckos are not poisonous. For some reason, there is a misconception that they are. Leopard geckos pose no threat to humans or other animals. [...] The idea of venom glands in leopard geckos may stem from a confusion between poison and venom. It’s important to remember that poisonous animals passively secrete or excrete toxins, while venomous animals actively inject their venom into their prey. Fortunately for you, leopard geckos are neither venomous nor poisonous. [...] The myth that leopard geckos are poisonous likely stems from their unique appearance. In the wild, bright colors on an animal generally signal it is poisonous. The colors act as a warning sign to potential predators. Add this to the fact that many reptiles are venomous and you can see where the misconception might come from.