evidence: Vitamin D is efficient at alleviating SARS-CoV-2 infection, according to a retrospective observational analysis of SARS-CoV-2 positivity in relation to serum 25(OH) D concentration measurements in the United States [18]. Data indicated that SARS-CoV-2 positivity in those with a serum concentration of 55 ng/mL was roughly half that of those with a serum value of 20 ng/ml. Data from a meta-analysis of 43 observational studies with a total of 612,601 patients indicated that among subjects with vitamin D deficiency (a serum 25(OH)D concentration < 20 ng/ml), the risk for COVID-19 infection was higher compared to those with serum 25(OH)D concentrations > 30 ng/mL (OR, 1.26; P < 0.01) [6]. Additionally, data from a large cohort study conducted in the United Kingdom indicated that supplementation with omega-3 fatty acids, probiotics, multivitamins, or vitamin D was related to a reduced risk of infection with the COVID-19 virus; however, vitamin C, zinc, or garlic supplementation did not show therapeutic effects against COVID-19 [19].