evidence: These days, standardised sterile medical grade Manuka honey is available, and there is considerable evidence demonstrating its antibacterial effect against a wide range of infections. Furthermore, we now have explanations for the different process by which this particular honey can kill both Staphylococcus aureus and Pseudomonas aeruginosa. Laboratory testing of antibiotics – such as oxacillin, rifampicin, tetracycline and colistin – has revealed that the drugs have an increased potency against either Pseudomonas aeruginosa or methicillin-resistant Staphylococcus aureus (MRSA) when combined with very low concentrations of medical grade Manuka honey. When used to fight MRSA, the honey damages the bacterial genes involved in creating resistance to oxacilin, which then allows oxacillin to better kill the bacteria. The specific mechanism by which Manuka honey restores the power of the other three antibiotics is not yet clear, though several different research groups have now reported the improved effectiveness of antibiotics when combined with honey. [...] As some infections are resistant to multiple antibiotics, some treatments combine two or more drugs to battle infections. Our research suggests that Manuka honey has the potential to be used in a similar way, combined with antibiotics. As most infections come from a mixture of different bacteria, identifying an antibiotic which works better against them when combined with honey would be the most useful. We have successfully seen this effect, using honey to improve the efficacy of the drug tetracycline against both Pseudomonas aeruginosa and MRSA.