evidence: The genome of the SARS-CoV was recently sequenced [8, 9]. Since it is a member of the Coronaviridae [10], the S2 protein is believed to play a central role in viral entry. Although we found no sequence homology between the SARS-CoV S2 and HIV-1 gp41, a comprehensive sequence analysis reveals that all the above-mentioned elements of gp41 are present also in S2. [...] Herein, we report the identification of the sequence in SARS-CoV S2 protein that is analogous to the C-HR of HIV-1 gp41. This led us to the suggestion that the viral entry mechanisms are analogous and therefore a therapeutic strategy that is being applied against the HIV-1 can be adopted to fight SARS-CoV. [...] Gallaher WR, Garry RF: Model of the pre-insertion region of the spike (S2) fusion glycoprotein of the human SARS coronavirus: implications for antiviral therapeutics.http://www.virology.net/sars/s2model.html