evidence: In a small study supported by the National Cancer Institute; the National Heart, Lung, and Blood Institute; the National Institute of Allergy and Infectious Diseases; and the National Institute on Minority Health and Health Disparities, researchers examined children after their COVID-19 vaccinations to learn more about their immune response. [...] All of the vaccinated children made antibodies against SARS-CoV-2. At the same dose as adults, children had a stronger antibody response than adults did. Children who received the adult dose also had a stronger antibody reaction than children who had tested positive for COVID-19 or children with acute MIS-C did. [...] This research helps show how children respond to vaccination and infection with the SARS-CoV-2 virus. The findings suggest that giving children a higher dose of a COVID-19 mRNA vaccine might allow them to recruit more of their immune system to fight an infection.