evidence: Overall, a graded reduction in the risk of clinical sequelae among infected patients was observed over time and with the increased number of doses of COVID-19 vaccines received prior to infection. Compared to non-infected controls, patients with SARS-CoV-2 infection were observed to incur a greater risk of clinical sequelae including major cardiovascular diseases [HR dose=0: 4.64 (4.00, 5.38); dose=1: 3.13 (2.60, 3.76); dose=2: 2.53 (2.21, 2.89); dose ≥3: 1.99 (1.72, 2.29)], and all-cause mortality [HR dose=0: 18.89 (18.07, 19.74); dose=1: 8.96 (8.46, 9.48); dose=2: 3.95 (3.71, 4.20); dose ≥3: 1.74 (1.50, 2.02)] across patients with different COVID-19 vaccination status during the acute phase of infection. A graded decrease in risk was observed in patients with a greater number of doses of COVID-19 vaccination with unvaccinated and incompletely vaccinated patients incurring a greater risk of most clinical sequelae than those completely vaccinated and those who received booster doses of vaccines. Most notably, there was an approximately five-fold reduction in risk of all-cause mortality between unvaccinated patients (18.89; 18.07,19.74) and patients with complete vaccination (3.95; 3.71, 4.20) during the acute phase of infection. Such risk was further reduced amongst patients who received booster dose of vaccines (1.74; 1.50, 2.02).