evidence: Microangiopathic dysfunction and hypotension are common findings in advanced sepsis (Pravda 2019a). H2O2 toxicity results in microangiopathic dysfunction and studies have reported hypotension in an animal model after intravenous administration of H2O2 (Shenep et al. 1985). Consistent with the known pathogenic effects of H2O2 is a report describing a fatal case of sepsis with multi-organ failure in a previously healthy 37-year-old man after receiving several intravenous infusions of H2O2 (Wetter and Davis 2006). [...] Shenep JL, Stokes DC, Hughes WT. Lack of antibacterial activity after intravenous hydrogen peroxide infusion in experimental Escherichia coli sepsis. Infect Immun. 1985;48:607–10. [...] Wetter DA, Davis MD. Ulceration of the arm attributed to a spider bite and treated with intravenous hydrogen peroxide: a cautionary tale. Arch Dermatol. 2006;142:1658–9.