evidence: Current scientific evidence does not support the use of hydroxychloroquine to prevent or cure COVID-19. In contrast to some small early studies showing an increased recovery rate among patients treated with hydroxychloroquine, more recent large and well-designed clinical trials showed no such improvement when the drug was used alone or in combination with zinc or azithromycin. In the absence of a proven cure for COVID-19, physical distancing, good hand hygiene, and the use of masks are effective measures for reducing the transmission of the disease.