evidence: As the U.S. death toll from COVID-19 continues to climb, many children and adolescents must deal with the significant adverse childhood experience of losing a loved one. According to a model published in JAMA Pediatrics, nearly 40,000 children have lost a parent to the coronavirus. [...] Health officials continue to wrestle with why some develop multisystem inflammatory syndrome in children (MIS-C), a rare but serious condition associated with COVID-19, and others do not. The case numbers of children afflicted with MIS-C so far are relatively small—as of April 2021, the CDC reports 3,185 cases nationwide and 36 deaths. [...] While hospitalization and death from COVID-19 is uncommon in children, providers are only beginning to understand the effects on the long-term physical health of infected children.