evidence: Researchers in The Netherlands and Germany have warned that Pfizer-BioNTech’s coronavirus disease 2019 (COVID-19) vaccine induces complex reprogramming of innate immune responses that should be considered in the development and use of mRNA-based vaccines. [...] The mRNA BNT162b2 vaccine induces complex functional reprogramming of innate immune responses, which should be considered in the development and use of this new class of vaccines," writes the team. [...] The scale of the pandemic has led to the accelerated development of new mRNA-based vaccines, the first of which to be registered was the BNT162b2 vaccine from Pfizer-BioNTech.