evidence: French Guiana - an overseas region and department of France is, divided into two arrondissements, 19 cantons and a total of 22 communes (towns and villages). Cayenne and Saint-Laurent Du Maroni are the two arrondissements. Saint-Laurent Du Maroni has 8 communes and Cayenne has 14 communes. Covering an area of 83,534 sq. km, French Guiana is France’s 2nd largest region. Located in the northwestern corner of the Island of Cayenne at the Cayenne River Estuary is Cayenne – the capital (prefecture) city of French Guiana. French Guiana is an overseas region and department of France that is located in the northeastern edge of South America. It is geographically positioned in the Northern and Western hemispheres of the Earth. French Guiana is bordered by Brazil in the east and south; by Suriname in the west and by the Atlantic Ocean in the northeast.