evidence: The study included 26,683 cases with SGTF status available. Based on whole-genome sequencing (WGS) results received for a subset of 1,383 positive specimens, we confirmed that all 704 cases exhibiting SGTF were Omicron (100%), and 673 of the 679 SGTF-negative cases were Delta (99.1%), with a kappa of 0.991. The sensitivity and specificity of SGTF in predicting Omicron was 99.2% and 100%, respectively. Of the 26,683 cases, 11,483 (43.0%) individuals were unvaccinated (2,883 Delta and 8,600 Omicron), and 15,200 (57.0%) individuals were vaccinated with mRNA-1273 (1,431 Delta and 13,769 Omicron; 416 vaccinated with one dose, 12,029 vaccinated with two doses and 2,755 vaccinated with three doses). The flow chart depicting the selection steps is provided (Fig. 1). The distribution of covariates by test outcomes, separated by variant type, is summarized in Table 1 (two-dose and three-dose analyses) and Supplementary Table 1 (one-dose analysis).