evidence: RSV vaccine developed in late sixties clearly failed. Fulginiti et al. (1969). Respiratory virus immunizations. I A field trial of two inactivated respiratory virus vaccines…Am J Epidemiology; 80 (4): 435-448) and others showed the vaccine ineffective, inducing exaggerated, altered clinical response…causing RSV illness requiring hospitalisations among vaccines and delayed dermal hypersensitivity. Simoes (1999. Respiratory syncytial virus infection. Lancet; 354: 847-852) wrote "Since it was identified as the agent that causes chimpanzee coryza in 1956, and after its subsequent isolation from children with pulmonary disease in Baltimore, USA, respiratory syncytial virus (RSV) had been described as the single most important virus causing acute respiratory-tract infections in children. The WHO estimates that of the 12.2. million annual deaths in children under 5 years, a third are due to acute infections of the lower respiratory tract. Streptococcus pneumoniae, Haemophilus influenzae, and RSV are the predominant pathogens… vaccinated children were not protected from subsequent RSV infection. Furthermore, RSV-naïve infants who received formalin-inactivated RSV vaccine, and who were naturally infected with RSV later, developed more severe disease in the lower respiratory tract than a control group immunized with a trivalent parainfluenza vaccine".