evidence: The Build Back Better package now heads to the Senate, where lawmakers in the upper chamber will continue negotiating elements of the bill. The Senate can then pass it with a simple majority through a budget mechanism called reconciliation, but Democrats can’t afford any defections from their 50-member caucus. That means moderate members of the party like West Virginia Sen. Joe Manchin and Arizona Sen. Kyrsten Sinema wield enormous power to alter the text of the bill. [...] The Build Back Better bill also delivers a compromise for taking on Big Pharma over rising drug prices: It would restrict how much drugmakers can increase their prices each year and set an annual limit on out-of-pocket spending, but only after those drugs have been on the market for about a decade. [...] The CBO findings are at odds with the White House’s pledge to fully pay for the Build Back Better bill, which is now expected to increase the federal budget deficit by $160 billion over the next 10 years.