evidence: The primary outcome was susceptibility to SARS-CoV-2 among PLWHA compared to their HIV-negative counterparts. A secondary outcome was the mortality risk of COVID-19 patients with HIV compared to COVID-19 patients without HIV. Predefined search terms determined by the Medical Subject Headings (MeSH) included multiple combinations of the following: "Human Immunodeficiency Virus" OR "HIV" OR "AIDS", AND "COVID-19" OR "Coronavirus." Studies found as a result of our initial search were transferred into Endnote, which further removed duplicate studies. [...] HIV remains an important risk factor of acquiring SARS-CoV-2 infection and is associated with a higher risk of mortality from COVID-19. Therefore, PLWHA should be prioritized for receiving a vaccine. Further studies are warranted to assess the long-term outcomes in PLWHA who survives COVID-19.