evidence: Our findings substantially add to the current understanding of the relationship between glucose normalization and outcomes in hyperglycemic patients with AMI and address some of the important knowledge gaps highlighted in the American Heart Association's scientific statement on hyperglycemia and acute coronary syndrome.32 Using unique features of our database, including detailed information about glucose measurements and insulin therapy, and the ability to perform detailed subgroup analyses because of the large sample size, we determined that postadmission glucose normalization is associated with improved survival. In addition, our findings suggest that targeting posttreatment glucose levels of about 80 to 130 mg/dL may represent a reasonable initial strategy in this patient group. Because a causal relationship between glucose normalization and improved survival cannot be established based on the results of our study, testing these potential treatment targets in large properly designed randomized clinical trials is the next logical and necessary step before their implementation in routine clinical practice.