evidence: Can manuka honey kill superbugs? The activity of manuka honey has been tested against a diverse range of microbes, particularly those that cause wound infections, and it inhibits problematic bacterial pathogens, including superbugs that are resistant to multiple antibiotics. Manuka honey can also disperse and kill bacteria living in biofilms (communities of microbes notoriously resistant to antibiotics), including ones of Streptococcus (the cause of strep throat) and Staphylococcus (the cause of Golden staph infections).