evidence: Both the Centers for Disease Control and Prevention (CDC) and the World Health Organization now recommend cloth masks for the general public, but earlier in the pandemic, both organizations recommended just the opposite. These shifting guidelines may have sowed confusion among the public about the utility of masks. [...] We talked to UC San Francisco epidemiologist George Rutherford, MD, and infectious disease specialist Peter Chin-Hong, MD, about the CDC’s reversal on mask-wearing, the current science on how masks work, and what to consider when choosing a mask. [...] What may have finally convinced the CDC to change its guidance in favor of masks were rising disease prevalence and a clearer understanding that both pre-symptomatic and asymptomatic transmission are possible – even common. Studies have found that viral load peaks in the days before symptoms begin and that speaking is enough to expel virus-carrying droplets.