evidence: Caffeine should largely work as expected if you take it while on Suboxone.[3] It is a stimulant, increasing nervous system activity and, by extension, generally making a user feel more alert and energetic. It could potentially worsen the gastrointestinal side effects Suboxone can sometimes cause, as caffeine is known to sometimes cause upset stomach or heartburn. [...] If you are looking for a safer alternative to caffeine while on Suboxone, avoid any supplement purported to be "energy boosting." This will essentially have all the same problems as mixing caffeine and Suboxone, except other stimulants are even less well-studied than caffeine. You should especially avoid potent and controlled stimulants unless you are prescribed them by a doctor who knows you are on Suboxone.