evidence: Key Points - Anaphylaxis, an acute and potentially life-threatening allergic reaction, has been reported rarely following COVID-19 vaccination. [...] Anaphylaxis, an acute and potentially life-threatening allergic reaction, has been reported rarely following COVID-19 vaccination. These interim considerations provide recommendations on assessment and potential management of anaphylaxis following COVID-19 vaccination. Detailed information on CDC recommendations for vaccination, including contraindications and precautions to vaccination, can be found in the Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States. Patients should be screened prior to receipt of each vaccine dose, and those with a contraindication should not be vaccinated. Resources from Immunize.org are available to help providers determine if a contraindication or precaution exists for all routinely recommended vaccines for adults and children and teens, including COVID-19 vaccines. [...] Anyone can report any adverse events, including anaphylaxis, that occur in a recipient following COVID-19 vaccination, to the Vaccine Adverse Event Reporting System (VAERS). Reporting is encouraged for any clinically significant adverse event, even if it is uncertain whether the vaccine caused the event. For detailed reporting requirements for VAERS, please see Clinical Guidance for COVID-19 Vaccination | CDC. Refer to the VAERS website or call 1-800-822-7967 for more information on how to submit a report to VAERS.