evidence: Study: Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Image Credit: Kateryna Kon / Shutterstock [...] Fungi seem like significant opportunistic pathogens that shape host immunity and infect cancer patients; however, they are understudied. It also remains unknown whether they could be part of polymorphic microbiomes representing cancer. This provided enough motivation to explore cancer clonal evolution as a multi-species process and characterize the pan-cancer mycobiome. Furthermore, since bacteria and fungi share symbiotic and antagonistic relationships in nature, studying their interactions in tumors could also potentially provide synergistic diagnostic performance for specific cancer(s). [...] - Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions, Lian Narunsky-Haziza, Gregory D. Sepich-Poore, Ilana Livyatan, Omer Asraf, Cameron Martino, Deborah Nejman, Nancy Gavert, Jason E. Stajich, Guy Amit, Antonio González, Stephen Wandro, Gili Perry, Ruthie Ariel, Arnon Meltser, Justin P. Shaffer, Qiyun Zhu, Nora Balint-Lahat, Iris Barshack, Maya Dadiani, Einav N. Gal-Yam, Sandip Pravin Patel, Amir Bashan, Austin D. Swafford, Yitzhak Pilpel, Rob Knight, Ravid Straussman, Cell 2022, DOI: https://doi.org/10.1016/j.cell.2022.09.005, https://www.cell.com/cell/fulltext/S0092-8674(22)01127-8