evidence: The most substantive evidence on the risk of severe COVID-19 and death in children and adolescents comes from studies in high resource settings, so the generalizability of the following observations to lower resource settings remains to be determined. One systematic review suggests that there may be larger impact of paediatric COVID-19 related fatality in low to middle income countries versus high income countries (16). [...] In the United States, during the period of Omicron predominance, COVID-19–associated hospitalization rates in children aged 5–11 years were studied in the COVID-19-Associated Hospitalization Surveillance Network. The cumulative hospitalization rate during the Omicron-predominant period was 2.1 times as high among unvaccinated children (19.1 per 100,000 population) as among vaccinated children (9.2). Non-Hispanic Black children represented the largest group of unvaccinated children. Thirty percent of hospitalized children had no underlying medical conditions, and 19% were admitted to an intensive care unit. Children with diabetes and obesity were more likely to experience severe COVID-19(30). [...] COVID-19 vaccines with WHO EUL that have undergone clinical trials in children and adolescent are safe and effective in preventing disease in children and adolescents. Children with comorbidities and severe immunocompromising conditions should be offered vaccination(36).