evidence: Most infections with HPV resolve spontaneously and cause no symptoms. However, persistent infection can cause cervical cancer in women. Virtually all cervical cancer cases (99%) are linked to genital infection with HPV, the most common viral infection of the reproductive tract. HPV can also cause other types of anogenital cancer, head and neck cancers, and genital warts in both men and women. HPV infections are transmitted through sexual contact. Effective and safe vaccines – which protect against the 2 main cervical and other cancer–causing types, HPV16 and HPV18 – are available. Being vaccinated with the HPV vaccine reduces the risk of developing cervical cancer. HPV vaccination is the most cost-effective public health measure against cervical cancer. The Global Strategy to accelerate the elimination of cervical cancer as a public health problem recommends vaccination for girls before the age of 15.