query: instance_of glycogen branching enzyme
supports: Starch or amylum is a polymeric carbohydrate consisting of a large number of glucose units joined by glycosidic bonds. This polysaccharide is produced by most green plants as an energy store. It is the most common carbohydrate in human diets and is contained in large amounts in staple foods such as potatoes, wheat, maize (corn), rice, and cassava. Glycogen synthase (UDP-glucose-glycogen glucosyltransferase) is a key enzyme in glycogenesis, the conversion of glucose into glycogen. It is a glycosyltransferase that catalyses the reaction of UDP-glucose and (1,4--D-glucosyl) to yield UDP and (1,4--D-glucosyl). In other words, this enzyme combines excess glucose residues one by one into a polymeric chain for storage as glycogen.  Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyze, chemical reactions. The molecules at the beginning of the process upon which enzymes may act are called substrates and the enzyme converts these into different molecules, called products. Almost all metabolic processes in the cell need enzymes in order to occur at rates fast enough to sustain life. The set of enzymes made in a cell determines which metabolic pathways occur in that cell. The study of enzymes is called "enzymology". Glycogenolysis is the breakdown of glycogen (n) to glucose-6-phosphate and glycogen (n-1). Glycogen branches are catabolized by the sequential removal of glucose monomers via phosphorolysis, by the enzyme glycogen phosphorylase. The blood sugar concentration or blood glucose level is the amount of glucose (sugar) present in the blood of a human or animal. The body naturally tightly regulates blood glucose levels as a part of metabolic homeostasis. Polysaccharides are polymeric carbohydrate molecules composed of long chains of monosaccharide units bound together by glycosidic linkages and on hydrolysis give the constituent monosaccharides or oligosaccharides. They range in structure from linear to highly branched. Examples include storage polysaccharides such as starch and glycogen, and structural polysaccharides such as cellulose and chitin. Phosphorylation is the addition of a phosphate group (PO) to a molecule. In biology, phosphorylation and its counterpart, dephosphorylation, are critical for many cellular processes. A large fraction of proteins are at least temporarily phosphorylated, as are many sugars, lipids, and other molecules. Phosphorylation is especially important for protein function as this modification activates (or deactivates) many enzymes, thereby regulating their function. Protein phosphorylation is one type of post-translational modification. Photosynthesis is a process used by plants and other organisms to convert light energy into chemical energy that can later be released to fuel the organisms' activities (energy transformation). This chemical energy is stored in carbohydrate molecules, such as sugars, which are synthesized from carbon dioxide and water  hence the name "photosynthesis", from the Greek , "phs", "light", and , "synthesis", "putting together". In most cases, oxygen is also released as a waste product. Most plants, most algae, and cyanobacteria perform photosynthesis; such organisms are called photoautotrophs. Photosynthesis is largely responsible for producing and maintaining the oxygen content of the Earth's atmosphere, and supplies all of the organic compounds and most of the energy necessary for life on Earth. Cellular respiration is a set of metabolic reactions and processes that take place in the cells of organisms to convert biochemical energy from nutrients into adenosine triphosphate (ATP), and then release waste products. The reactions involved in respiration are catabolic reactions, which break large molecules into smaller ones, releasing energy in the process, as weak so-called "high-energy" bonds are replaced by stronger bonds in the products. Respiration is one of the key ways a cell releases chemical energy to fuel cellular activity. Cellular respiration is considered an exothermic redox reaction which releases heat. The overall reaction occurs in a series of biochemical steps, most of which are redox reactions themselves. Although technically, cellular respiration is a combustion reaction, it clearly does not resemble one when it occurs in a living cell because of the slow release of energy from the series of reactions. Glycogenesis is the process of glycogen synthesis, in which glucose molecules are added to chains of glycogen for storage. This process is activated during rest periods following the Cori cycle, in the liver, and also activated by insulin in response to high glucose levels, for example after a carbohydrate-containing meal. Glycogen phosphorylase is one of the phosphorylase enzymes. Glycogen phosphorylase catalyzes the rate-limiting step in glycogenolysis in animals by releasing glucose-1-phosphate from the terminal alpha-1,4-glycosidic bond. Glycogen phosphorylase is also studied as a model protein regulated by both reversible phosphorylation and allosteric effects. A polymer (Greek "poly-", "many" + "-mer", "parts") is a large molecule, or macromolecule, composed of many repeated subunits. Because of their broad range of properties, both synthetic and natural polymers play an essential and ubiquitous role in everyday life. Polymers range from familiar synthetic plastics such as polystyrene to natural biopolymers such as DNA and proteins that are fundamental to biological structure and function. Polymers, both natural and synthetic, are created via polymerization of many small molecules, known as monomers. Their consequently large molecular mass relative to small molecule compounds produces unique physical properties, including toughness, viscoelasticity, and a tendency to form glasses and semicrystalline structures rather than crystals. Water is a transparent and nearly colorless chemical substance that is the main constituent of Earth's streams, lakes, and oceans, and the fluids of most living organisms. Its chemical formula is HO, meaning that its molecule contains one oxygen and two hydrogen atoms, that are connected by covalent bonds. Water strictly refers to the liquid state of that substance, that prevails at standard ambient temperature and pressure; but it often refers also to its solid state (ice) or its gaseous state (steam or water vapor). It also occurs in nature as snow, glaciers, ice packs and icebergs, clouds, fog, dew, aquifers, and atmospheric humidity. Glycogen branching enzyme is an enzyme that adds branches to the growing glycogen molecule during the synthesis of glycogen , a storage form of glucose . More specifically , during glycogen synthesis , a glucose 1 - phosphate molecule reacts with uridine triphosphate ( UTP ) to become UDP - glucose , an activated form of glucose . The activated glucosyl unit of UDP - glucose is then transferred to the hydroxyl group at the C - 4 of a terminal residue of glycogen to form an  - 1,4 - glycosidic linkage , a reaction catalyzed by glycogen synthase . Importantly , glycogen synthase can only catalyze the synthesis of  - 1,4 - glycosidic linkages . Since glycogen is a readily mobilized storage form of glucose , the extended glycogen polymer is branched by glycogen branching enzyme to provide glycogen breakdown enzymes , such as glycogen phosphorylase , with a large number of terminal residues for rapid degradation . Branching also importantly increases the solubility and decreases the osmotic strength of glycogen . Modern humans ("Homo sapiens", primarily ssp. "Homo sapiens sapiens") are the only extant members of Hominina tribe (or human tribe), a branch of the tribe Hominini belonging to the family of great apes. They are characterized by erect posture and bipedal locomotion; manual dexterity and increased tool use, compared to other animals; and a general trend toward larger, more complex brains and societies. Glucose is a simple sugar with the molecular formula CHO. Glucose circulates in the blood of animals as blood sugar. It is made during photosynthesis from water and carbon dioxide, using energy from sunlight. The reverse of the photosynthesis reaction, which releases this energy, is an important source of power for cellular respiration. Glucose is stored as a polymer, in plants as starch and in animals as glycogen, for times when the organism will need it. Carbon (from "coal") is a chemical element with symbol C and atomic number 6. It is nonmetallic and tetravalentmaking four electrons available to form covalent chemical bonds. Three isotopes occur naturally, C and C being stable, while C is a radioactive isotope, decaying with a half-life of about 5,730 years. Carbon is one of the few elements known since antiquity. Sugar is the generalized name for sweet, short-chain, soluble carbohydrates, many of which are used in food. They are composed of carbon, hydrogen, and oxygen. There are various types of sugar derived from different sources. Simple sugars are called monosaccharides and include glucose (also known as dextrose), fructose, and galactose. The table or granulated sugar most customarily used as food is sucrose, a disaccharide. (In the body, sucrose hydrolyses into fructose and glucose.) Other disaccharides include maltose and lactose. Longer chains of sugars are called oligosaccharides. Chemically-different substances may also have a sweet taste, but are not classified as sugars. Some are used as lower-calorie food substitutes for sugar, described as artificial sweeteners. Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in humans, animals and fungi. The polysaccharide structure represents the main storage form of glucose in the body. Glycosyltransferases (abbre. GTFs, Gtfs) are enzymes (EC 2.4) that establish natural glycosidic linkages. They catalyze the transfer of saccharide moieties from an activated nucleotide sugar (also known as the "glycosyl donor") to a nucleophilic glycosyl acceptor molecule, the nucleophile of which can be oxygen- carbon-, nitrogen-, or sulfur-based. In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell. The reactants, products, and intermediates of an enzymatic reaction are known as metabolites, which are modified by a sequence of chemical reactions catalyzed by enzymes. In a metabolic pathway, the product of one enzyme acts as the substrate for the next. These enzymes often require dietary minerals, vitamins, and other cofactors to function. Phosphorylases are enzymes that catalyze the addition of a phosphate group from an inorganic phosphate (phosphate+hydrogen) to an acceptor.
  They include allosteric enzymes that catalyze the production of glucose-1-phosphate from a glucan such as glycogen, starch or maltodextrin. Phosphorylase is also a common name used for glycogen phosphorylase in honor of Earl W. Sutherland Jr. who in the late 1930s discovered the first phosphorylase. In physics, energy is the property that must be transferred to an object in order to perform work on  or to heat  the object, and can be converted in form, but not created or destroyed. The SI unit of energy is the joule, which is the energy transferred to an object by the mechanical work of moving it a distance of 1 metre against a force of 1 newton. Animals are multicellular, eukaryotic organisms of the kingdom Animalia (also called Metazoa). The animal kingdom emerged as a basal clade within Apoikozoa as a sister of the choanoflagellates. Sponges are the most basal clade of animals. Animals are motile, meaning they can move spontaneously and independently at some point in their lives. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later in their lives. All animals are heterotrophs: they must ingest other organisms or their products for sustenance. A molecule is an electrically neutral group of two or more atoms held together by chemical bonds. Molecules are distinguished from ions by their lack of electrical charge. However, in quantum physics, organic chemistry, and biochemistry, the term "molecule" is often used less strictly, also being applied to polyatomic ions.
candidates: 1 activity addition animal bond chain chemical chemical element chemical substance clade common name complex distance earl energy enzyme formula group homo human humans hydrogen key may molecular formula molecule name number order part phosphate physics plan plastics point polymer polysaccharide process product production protein range role sequence series set state store structure symbol temperature three tribe unit of energy water will work
answer: protein