query: instance_of tequila and tonic
supports: Jalisco, officially the Free and Sovereign State of Jalisco, is one of the 31 states which, with the Federal District, comprise the 32 Federal Entities of Mexico. It is located in Western Mexico and divided into 125 municipalities, and its capital city is Guadalajara. Jalisco is one of the most important states in Mexico because of its natural resources as well as its history. Many of the characteristic traits of Mexican culture, particularly outside Mexico City, are originally from Jalisco, such as mariachi, ranchera music, birria, tequila, jaripeo, etc. Hence, the state's motto: "Jalisco es México." Economically, it is ranked third in the country, with industries centered in the Guadalajara metropolitan area, the second largest metropolitan area in Mexico.
  The state is home to two significant indigenous populations, the Huichols and the Nahuas. There is also a significant foreign population, mostly retirees from the United States and Canada, living in the Lake Chapala and Puerto Vallarta areas. Tonic water (or Indian tonic water) is a carbonated soft drink in which quinine is dissolved. Originally used as a prophylactic against malaria, tonic water usually now has a significantly lower quinine content and is consumed for its distinctive bitter flavour. It is often used in mixed drinks, particularly in gin and tonic. A gin and tonic is a highball cocktail made with gin and tonic water poured over ice. It is usually garnished with a slice or wedge of lime. The amount of gin varies according to taste. Suggested ratios of gin to tonic are between 1:1 and 1:3. Tequila and Tonic is a non-standard highball beverage also known as a TnT , Teqtonic . The drink is made with a 2:1 ratio of Tonic water to Tequila and is served with lemon or lime wedges on ice . Malaria is a mosquito-borne infectious disease affecting humans and other animals caused by parasitic protozoans (a group of single-celled microorganisms) belonging to the "Plasmodium" type. Malaria causes symptoms that typically include fever, fatigue, vomiting, and headaches. In severe cases it can cause yellow skin, seizures, coma, or death. Symptoms usually begin ten to fifteen days after being bitten. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria.
  The disease is most commonly transmitted by an infected female "Anopheles" mosquito. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver where they mature and reproduce. Five species of "Plasmodium" can infect and be spread by humans. Most deaths are caused by "P. falciparum" because "P. vivax", "P. ovale", and "P. malariae" generally cause a milder form of malaria. The species "P. knowlesi" rarely causes disease in humans. Malaria is typically diagnosed by the microscopic examination of blood using blood films, or with antigen-based rapid diagnostic tests. Methods that use the polymerase chain reaction to detect the parasite's DNA have been developed, but are not widely used in areas where malaria is common due to their cost and complexity.
  The risk of disease can be reduced by preventing mosquito bites through the use of mosquito nets and insect repellents, or with mosquito control measures such as spraying insecticides and draining standing water. Several medications are available to prevent malaria in travellers to areas where the disease is common. Occasional doses of the combination medication sulfadoxine/pyrimethamine are recommended in infants and after the first trimester of pregnancy in areas with high rates of malaria. Despite a need, no effective vaccine exists, although efforts to develop one are ongoing. The recommended treatment for malaria is a combination of antimalarial medications that includes an artemisinin. The second medication may be either mefloquine, lumefantrine, or sulfadoxine/pyrimethamine. Quinine along with doxycycline may be used if an artemisinin is not available. It is recommended that in areas where the disease is common, malaria is confirmed if possible before treatment is started due to concerns of increasing drug resistance. Resistance among the parasites has developed to several antimalarial medications; for example, chloroquine-resistant "P. falciparum" has spread to most malarial areas, and resistance to artemisinin has become a problem in some parts of Southeast Asia.
  The disease is widespread in the tropical and subtropical regions that exist in a broad band around the equator. This includes much of Sub-Saharan Africa, Asia, and Latin America. In 2015, there were 214 million cases of malaria worldwide resulting in an estimated 438,000 deaths, 90% of which occurred in Africa. Rates of disease have decreased from 2000 to 2015 by 37%, but increased from 2014 during which there were 198 million cases. Malaria is commonly associated with poverty and has a major negative effect on economic development. In Africa, it is estimated to result in losses of US$12 billion a year due to increased healthcare costs, lost ability to work, and negative effects on tourism. Highball is the name for a family of mixed alcoholic drinks that are composed of an alcoholic base spirit and a larger proportion of a non-alcoholic mixer. A mixed drink is a beverage in which two or more ingredients are mixed. Some mixed drinks contain liquor; others are non-alcoholic. In chemistry, esters are chemical compounds derived from an acid (organic or inorganic) in which at least one OH (hydroxyl) group is replaced by an Oalkyl (alkoxy) group. Usually, esters are derived from a carboxylic acid and an alcohol. Glycerides, which are fatty acid esters of glycerol, are important esters in biology, being one of the main classes of lipids, and making up the bulk of animal fats and vegetable oils. Esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Phosphoesters form the backbone of DNA molecules. Nitrate esters, such as nitroglycerin, are known for their explosive properties, while polyesters are important plastics, with monomers linked by ester moieties. A distilled beverage, spirit, liquor, hard liquor or hard alcohol is an alcoholic beverage produced by distillation of a mixture produced from alcoholic fermentation. This process purifies it and removes diluting components like water, for the purpose of increasing its proportion of alcohol content (commonly expressed as alcohol by volume, ABV). As distilled beverages contain more alcohol, they are considered "harder"  in North America, the term "hard liquor" is used to distinguish distilled beverages from undistilled ones. Tequila is a regionally specific name for a distilled beverage made from the blue agave plant, primarily in the area surrounding the city of Tequila, northwest of Guadalajara, and in the highlands ("Los Altos") of the central western Mexican state of Jalisco. Although tequila is similar to mezcal, modern tequila differs somewhat in the method of its production, in the use of only blue agave plants, as well as in its regional specificity. Tequila is commonly served neat in Mexico and as a shot with salt and lime across the rest of the world. Agave (US: , UK: , Anglo-Hispanic: ) is a genus of monocots native to the hot and arid regions of Mexico and the Southwestern United States. Some agave species are also native to tropical areas of South America. The plants are perennial, but each rosette flowers once and then dies (see semelparity). Some species are known by the name "century plant". Gin is a spirit which derives its predominant flavour from juniper berries ("Juniperus communis"). From its earliest origins in the Middle Ages, gin has evolved from a herbal medicine to an object of commerce in the spirits industry. Gin was developed on the basis of the older jenever, and became popular in Great Britain (particularly in London) when William of Orange, leader of the Dutch Republic, occupied the English, Scottish, and Irish thrones with his wife Mary. Gin is one of the broadest categories of spirits, represented by products of various origins, styles, and flavour profiles that all revolve around juniper as a common ingredient. Mezcal (or mescal) is a distilled alcoholic beverage made from any type of agave plant native to Mexico. The word "mezcal" comes from Nahuatl "mexcalli" "metl" and "ixcalli" which means "oven-cooked agave".
candidates: 1 alcohol alcoholic beverage area band base biology carboxylic acid chemical cocktail combination cost country culture disease distilled beverage district drink family federal district fermentation genus gin group highball home humans infectious ingredient may medicine metropolitan metropolitan area mixed drink music name object people person plant production result salt soft drink sovereign state species spirit state ten the city tourism two vaccine vegetable volume vomiting water year
answer: cocktail