query: date_of_death albert hofmann
supports: Sir Timothy John Berners-Lee (born 8 June 1955), also known as TimBL, is an English computer scientist, best known as the inventor of the World Wide Web. He made a proposal for an information management system in March 1989, and he implemented the first successful communication between a Hypertext Transfer Protocol (HTTP) client and server via the Internet sometime around mid-November of that same year. Lysergic acid diethylamide (LSD), also known as acid, is a psychedelic drug known for its psychological effects. This may include altered awareness of the surroundings, perceptions, and feelings as well as sensations and images that seem real though they are not. It is used mainly as a recreational drug and for spiritual reasons. LSD is typically either swallowed or held under the tongue. It is often sold on blotter paper, a sugar cube, or gelatin. It can also be injected.
  LSD is not addictive. However, adverse psychiatric reactions such as anxiety, paranoia, and delusions are possible. LSD is in the ergoline family. LSD is sensitive to oxygen, ultraviolet light, and chlorine, though it may last for years if it is stored away from light and moisture at low temperature. In pure form it is odorless and clear or white in color. As little as 2030 micrograms can produce an effect.
  LSD was first made by Albert Hofmann in Switzerland in 1938 from ergotamine, a chemical from the fungus ergot. The laboratory name for the compound was the acronym for the German "Lyserg-säure-diäthylamid", followed by a sequential number: LSD-25. Hofmann discovered its psychedelic properties in 1943. LSD was introduced as a commercial medication under the trade-name Delysid for various psychiatric uses in 1947. In the 1950s, officials at the U.S. Central Intelligence Agency (CIA) thought the drug might be useful for mind control and chemical warfare and tested the drug on young servicemen and students, and others without their knowledge. The subsequent recreational use by youth culture in the Western world as part of 1960s counterculture resulted in its prohibition. An amide (or or ), also known as an acid amide, is a compound with the functional group RE(O)NR (R and R refer to H or organic groups). Most common are carboxamides (organic amides) ("n" = 1, E = C, "x" = 1), but many other important types of amides are known, including phosphoramides ("n" = 2, E = P, "x" = 1 and many related formulas) and sulfonamides (E = S, "x" = 2). The term amide refers both to "classes of compounds" and to the "functional group" (RE(O)NR) within those compounds. Albert Hofmann ( January 11 , 1906 -- April 29 , 2008 ) was a Swiss scientist known best for being the first person to synthesize , ingest , and learn of the psychedelic effects of lysergic acid diethylamide ( LSD ) . Hofmann was also the first person to isolate , synthesize , and name the principal psychedelic mushroom compounds psilocybin and psilocin . He authored more than 100 scientific articles and numerous books , including LSD : Mein Sorgenkind ( LSD : My Problem Child ) . In 2007 , he shared first place , alongside Tim Berners - Lee , in a list of the 100 greatest living geniuses , published by The Telegraph newspaper . Lysergic acid, also known as -lysergic acid and (+)-lysergic acid, is a precursor for a wide range of ergoline alkaloids that are produced by the ergot fungus and found in the seeds of "Turbina corymbosa" (ololiuhqui), "Argyreia nervosa" (Hawaiian Baby Woodrose), and "Ipomoea tricolor" (morning glories, tlitliltzin). Amides of lysergic acid, lysergamides, are widely used as pharmaceuticals and as psychedelic drugs (LSD). Lysergic acid received its name as it was a product of the lysis of various ergot alkaloids. The World Wide Web (abbreviated WWW or the Web) is an information space where documents and other web resources are identified by Uniform Resource Locators (URLs), interlinked by hypertext links, and can be accessed via the Internet. English scientist Tim Berners-Lee invented the World Wide Web in 1989. He wrote the first web browser computer program in 1990 while employed at CERN in Switzerland. Switzerland, officially the Swiss Confederation, is a federal republic in Europe. It consists of 26 cantons, and the city of Bern is the seat of the federal authorities. 
  The country is situated in Western-Central Europe, and is bordered by Italy to the south, France to the west, Germany to the north, and Austria and Liechtenstein to the east. Switzerland is a landlocked country geographically divided between the Alps, the Swiss Plateau and the Jura, spanning an area of . While the Alps occupy the greater part of the territory, the Swiss population of approximately eight million people is concentrated mostly on the plateau, where the largest cities are to be found: among them are the two global cities and economic centres Zürich and Geneva. The Convention on Psychotropic Substances of 1971 is a United Nations treaty designed to control psychoactive drugs such as amphetamine-type stimulants, barbiturates, benzodiazepines, and psychedelics signed in Vienna, Austria on 21 February 1971. The Single Convention on Narcotic Drugs of 1961 could not ban the many newly discovered psychotropics, since its scope was limited to drugs with cannabis, coca, and opium-like effects. Psilocin (also known as 4-HO-DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocybin. Psilocin is a Schedule I drug under the Convention on Psychotropic Substances. The mind-altering effects of psilocin are highly variable and subjective and resemble those of LSD and DMT. A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Inactive prodrugs are pharmacologically inactive medications that are metabolized into an active form within the body. Instead of administering a drug directly, a corresponding prodrug might be used instead to improve how a medicine is absorbed, distributed, metabolized, and excreted (ADME). Prodrugs are often designed to improve bioavailability when a drug itself is poorly absorbed from the gastrointestinal tract. A prodrug may be used to improve how selectively the drug interacts with cells or processes that are not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects.
  History.
  Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a -D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine, the administered drug is enzymatically activated to form sugar derivatives (morphine-glucuronides) that are more active than the parent compound. Chlorine is a chemical element with symbol Cl and atomic number 17. The second-lightest of the halogens, it appears between fluorine and bromine in the periodic table and its properties are mostly intermediate between them. Chlorine is a yellow-green gas at room temperature. It is an extremely reactive element and a strong oxidising agent: among the elements, it has the highest electron affinity and the third-highest electronegativity, behind only oxygen and fluorine. Psilocybin is a naturally occurring psychedelic compound produced by more than 200 species of mushrooms, collectively known as psilocybin mushrooms. The most potent are members of the genus "Psilocybe", such as "P. azurescens", "P. semilanceata", and "P. cyanescens", but psilocybin has also been isolated from about a dozen other genera. As a prodrug, psilocybin is quickly converted by the body to psilocin, which has mind-altering effects similar, in some aspects, to those of LSD, mescaline, and DMT. In general, the effects include euphoria, visual and mental hallucinations, changes in perception, a distorted sense of time, and spiritual experiences, and can include possible adverse reactions such as nausea and panic attacks. Mescaline, or 3,4,5-trimethoxyphenethylamine, is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Panic attacks are sudden periods of intense fear that may include palpitations, sweating, shaking, shortness of breath, numbness, or a feeling that something bad is going to happen. The maximum degree of symptoms occurs within minutes. Typically they last for about 30 minutes but the duration can vary from seconds to hours. There may be a fear of losing control or chest pain. Panic attacks themselves are not dangerous.
  Panic attacks can occur due to number of disorders including panic disorder, social anxiety disorder, post traumatic stress disorder, drug use, depression, and medical problems. They can either be triggered or occur unexpectedly. Risk factors include smoking and psychological stress. Diagnosis should involve ruling out other conditions that can produce similar symptoms including hyperthyroidism, hyperparathyroidism, heart disease, lung disease, and drug use.
  Treatment of panic attacks should be directed at the underlying cause. In those with frequent attacks, counselling or medications may be used. Breathing training and muscle relaxation techniques may also help. Those affected are at a higher risk of suicide.
  In Europe about 3% of the population has a panic attack in a given year while in the United States they affect about 11%. They are more common in females than males. They often begin during puberty or early adulthood. Children and older people are less commonly affected. Albert Hofmann (11 January 1906  29 April 2008) was a Swiss scientist known best for being the first person to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann was also the first person to isolate, synthesize, and name the principal psychedelic mushroom compounds psilocybin and psilocin. He authored more than 100 scientific articles and numerous books, including "LSD: Mein Sorgenkind" ("LSD: My Problem Child"). In 2007, he shared first place, alongside Tim Berners-Lee, in a list of the 100 greatest living geniuses, published by "The Telegraph" newspaper. Ipomoea tricolor (grannyvine or morning glory) is a species of flowering plant in the family Convolvulaceae, native to the New World tropics, and widely cultivated and naturalised elsewhere. It is an herbaceous annual or perennial twining liana growing to tall. The leaves are spirally arranged, 37 cm long with a 1.56 cm long petiole. The flowers are trumpet-shaped, in diameter, most commonly blue with a white to golden yellow centre.
candidates: 1 11 january 1906 17 1897 1906 1938 1943 1955 1961 1971 1989 1990 2 20 200 2008 26 29 29 april 2008 30 4 6 7 8 june 1955 march 1989
answer: 29 april 2008