query: date_of_birth clopton havers
supports: A physician, medical practitioner, medical doctor or simply doctor is a professional who practises medicine, which is concerned with promoting, maintaining, or restoring health through the study, diagnosis, and treatment of disease, injury, and other physical and mental impairments. Physicians may focus their practice on certain disease categories, types of patients and methods of treatmentknown as specialitiesor they may assume responsibility for the provision of continuing and comprehensive medical care to individuals, families, and communitiesknown as general practice. Medical practice properly requires both a detailed knowledge of the academic disciplines (such as anatomy and physiology) underlying diseases and their treatmentthe "science" of medicineand also a decent competence in its applied practicethe art or "craft" of medicine. A profession is a vocation founded upon specialized educational training, the purpose of which is to supply disinterested objective counsel and service to others, for a direct and definite compensation, wholly apart from expectation of other business gain. The term is a truncation of the term "liberal profession", which is, in turn, an Anglicization of the French term "profession libérale". Originally borrowed by English users in the 19th century, it has been re-borrowed by international users from the late 20th, though the (upper-middle) class overtones of the term do not seem to survive retranslation: "liberal professions" are, according to the European Union's Directive on Recognition of Professional Qualifications (2005/36/EC) "those practiced on the basis of relevant professional qualifications in a personal, responsible and professionally independent capacity by those providing intellectual and conceptual services in the interest of the client and the public". Health is the level of functional and metabolic efficiency of a living organism. In humans it is the ability of individuals or communities to adapt and self-manage when facing physical, mental or social changes. The World Health Organization (WHO) defined health in its broader sense in its 1948 constitution as "a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity." This definition has been subject to controversy, in particular as lacking operational value, the ambiguity in developing cohesive health strategies, and because of the problem created by use of the word "complete". Other definitions have been proposed, among which a recent definition that correlates health and personal satisfaction. Clopton Havers (24 February 1657 (Stambourne, Essex) - April 1702) was an English physician who did pioneering research on the microstructure of bone. He is believed to have been the first person to observe and almost certainly the first to describe what are now called Haversian canals and Sharpey's fibres. Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content. Depending upon the degree of mineralization, collagen tissues may be rigid (bone), compliant (tendon), or have a gradient from rigid to compliant (cartilage). Collagen, in the form of elongated fibrils, is mostly found in fibrous tissues such as tendons, ligaments and skin. It is also abundant in corneas, cartilage, bones, blood vessels, the gut, intervertebral discs and the dentin in teeth. In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. The fibroblast is the most common cell that creates collagen. Stambourne is a village and civil parish in the Braintree District in north Essex, England. The population at the 2011 Census was 409. Braintree is a local government district in the English county of Essex, with a population (2011 census) of 147,084. Its main town is Braintree. Haversian canals (sometimes canals of Havers, named after British physician Clopton Havers) are a series of microscopic tubes in the outermost region of bone called cortical bone that allow blood vessels and nerves to travel through them. Each haversian canal generally contains one or two capillaries and nerve fibres. The channels are formed by concentric layers called lamellae. The haversian canals surround blood vessels and nerve cells throughout bones and communicate with bone cells (contained in spaces within the dense bone matrix called lacunae) through connections called canaliculi. This unique arrangement is conducive to mineral salt deposits and storage which gives bone tissue its strength. Sharpey's fibres (bone fibres, or perforating fibres) are a matrix of connective tissue consisting of bundles of strong predominantly type I collagen fibres connecting periosteum to bone. They are part of the outer fibrous layer of periosteum, entering into the outer circumferential and interstitial lamellae of bone tissue. Clopton Havers ( 24 Feb 1657 ( Stambourne , Essex ) - Apr 1702 ) was an English physician who did pioneering research on the microstructure of bone . He is believed to have been the first person to observe and almost certainly the first to describe what are now called Haversian canals and Sharpey 's fibres .
candidates: 147 1948 2005 24 february 1657 25 35 409 6
answer: 24 february 1657