Melanin-concentrating hormone receptor

Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.
Clinical significance.
Antagonists might be useful in the treatment of obesity and anxiety and depression. An agonist might have possible utility as a treatment for osteoporosis and insomnia
Research is ongoing for antagonists affecting MCH receptors R1 and R2.