HrrF RNA

HrrF RNA ("Haemophilus" regulatory RNA responsive to iron Fe) is a small non-coding RNA involved in iron homeostasis in "Haemophilus" species. Orthologues exist only among other "Pasteurellacae." Iron- regulated sRNAs JA01- JA04 were identified in related "Aggregatibacte"r. It is an analog to PrrF and RyhB RNAs. HrrF is maximally expressed when iron levels are low. Ferric uptake regulator (Fur) binds upstream of the "hrrF" promoter. HrrF stability is not dependent on the RNA chaperone Hfq. RNA-seq has shown that HrrF targets are mRNAs of genes whose products are involved in molybdate uptake, deoxyribonucleotide synthesis, and amino acid synthesis.