GyrA RNA motif

The "gyrA" RNA motif is a conserved RNA structure identified by bioinformatics. The RNAs are present in multiple species of bacteria within the order Pseudomonadales. This order contains the genus "Pseudomonas", which includes the opportunistic human pathogen "Pseudomonas aeruginosa" and "Pseudomonas syringae", a plant pathogen.
"gyrA" RNAs are always found in the presumed 5' untranslated regions of "gyrA" genes, which encodes a protein forming a subunit of a DNA gyrase. Resistance to the antibiotic ciprofloxacin in "Pseudomonas" is often achieved via mutations in the "gyrA" gene. Because of its positioning, the "gyrA" RNA motif was hypothesized to be a cis-regulatory element acting up the downstream "gyrA" genes. However, "gyrA" was previously regarded as a gene whose level of expression is consistent in a wide variety of growth conditions.