The ACTH receptor is a seven membrane-spanning G-protein coupled to adenylyl cyclase, which leads to an increase in intraceullar cAMP and subsequent activation of protein kinase A. This ultimately results in stimulation of steroidogenesis.
The ACTH receptor is a seven membrane-spanning G-protein coupled receptor. Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intraceullar cAMP and subsequent activation of protein kinase A. This ultimately results in stimulation of steroidogenesis.