Highway 101 begins at U.S.62 east of Mountain Home near Lake Norfork and runs north approximately passing through the community of Gamaliel before crossing into Missouri where the road continues as Route 101.
Highway 101 begins at an overlap between US 62/US 412 east of Mountain Home near Lake Norfork. Highway continues north through the community of Gamaliel before crossing into Missouri where the roadway continues as Route 101.