She bore him one son, Edward William Cornelius Humphrey, who became a lawyer, and one young daughter who died shortly after Catherine died during childbirth on September 28,1844.
She bore him one son, Edward William Cornelius Humphrey, who became a legal expert and representative to the national Presbyterian General Assembly. Edward and Catherine also had one young daughter who died as an infant shortly after Catherine died during childbirth on September 28,1844.