However, with regard to glutamate transport and metabolism no such drugs have been developed This is because glutamatergic synapses are abundant and the neurotransmitter glutamate is an important metabolite in metabolism, making interference capable of adverse effects.
However, with regard to glutamate transport and metabolism no such drugs have been developed, although malfunctions in the glutamate-glutamine cycle clearly are present. This probably reflects that glutamatergic synapses are so abundant and that glutamate is an important metabolite in intermediary metabolism, making interference with glutamate homeostasis a potential nightmare of adverse effects.