Interestingly, Obscurin is the major cytoplasmic ligand for small ankyrin 1, a sarcoplasmic reticular protein, suggesting that Obscurin may serve as a signaling link between the sarcomeric and sarcoplasmic reticular domains.
Interestingly, Obscurin is the major cytoplasmic ligand for small ankyrin 1 (sANK1), a sarcoplasmic reticular protein, and the scaffolding function of obscurin appears to prevent degradation of sANK1. These data indicate that obscurin serves as a signaling link between the sarcomeric and sarcoplasmic reticular domains.