In the kidneys, the tubuloglomerular feedback (TGF) is one of several mechanisms used to regulate glomerular filtration rate (GFR), in which an increased distal tubular sodium chloride concentration causes a basolateral release of ATP from the macula densa cells.
In the kidneys, the tubuloglomerular feedback (TGF) is one of several mechanisms used to regulate glomerular filtration rate (GFR). TGF is based on the concept of purinergic signalling, in which an increased distal tubular sodium chloride concentration causes a basolateral release of ATP from the macula densa cells.