In the "Ultimate Spider-Man" universe, the Venom suit is a man-made creation born of an experiment by Richard Parker and Edward Brock, Sr. to develop a protoplasmic cure for cancer.
In the "Ultimate Spider-Man" universe, the symbiote has vastly changed. The fathers of Peter Parker and Eddie Brock Jr. (Richard "Ray" Parker and Edward Brock, Sr.) had created the suit as a protoplasmic cure for cancer.