In 1859 he married Asia Booth, daughter of Junius Brutus Booth, and he was associated with his brother-in-law Edwin Booth in the management of the Winter Garden theatre in New York, the Walnut Street theatre in Philadelphia and the Boston theatre.
In 1859 he married Asia Booth, daughter of Junius Brutus Booth, and sister of John Wilkes Booth. Clarke was associated with his brother-in-law Edwin Booth in the management of the Winter Garden theatre in New York, the Walnut Street theatre in Philadelphia and the Boston theatre.