The primary cause is deficiency of an acidic hydrolase, while there are conditions of defects in lysosomal membrane proteins that fail to transport the enzyme, or non-enzymatic soluble lysosomal proteins.
The primary cause is deficiency of an acidic hydrolase (a hydrolase which functions best in acidic environments). Other conditions are due to defects in lysosomal membrane proteins that fail to transport the enzyme, non-enzymatic soluble lysosomal proteins.