This polymerase is required to maintain a threshold level of the repeat RNA, which causes the paramutation by covalently modifying the DNA and/or the DNA-bound histone proteins without changing the DNA sequence of the genes themselves.
This polymerase is required to maintain a threshold level of the repeat RNA, which causes the paramutation. Exactly how the RNA does this is not understood, but a covalent modification the DNA and/or the DNA-bound histone proteins occurs without changing the DNA sequence of the genes themselves.