Released in 2008, "Devil May Cry 4" is chronologicly the first game in the series, and is the first game in the series not to feature Dante as the primary character.
Released in 2008, "Devil May Cry 4" in the series chronology, takes place after "Devil May Cry", but before "Devil May Cry 2". It is the first game in the series not to feature Dante as the primary character.