A major breakthrough was achieved with the discovery of the first well-tolerated orally available diuretics, the first of which was was chlorothiazide, which was derived from the antibiotic sulfanilamide, which became available in 1958; it increased salt excretion while preventing fluid accumulation.
A major breakthrough was achieved with the discovery of the first well-tolerated orally available agents. The first was chlorothiazide, the first thiazide diuretic and developed from the antibiotic sulfanilamide, which became available in 1958; it increased salt excretion while preventing fluid accumulation.