Symptoms and signs due to the cryoglobulins of Type I croglobulinemic disease may reflect the hyperviscosity and consequential poor tissue perfusion of blood containing particularly high levels of these proteins, e.g. neurological symptoms of confusion, headache, and hearing loss, and peripheral neuropathy.
Symptoms and signs due to the cryoglobulins of Type I disease reflect the hyperviscosity and intravascular deposition of cryoglobulins which reduce or stop blood perfusion to tissues. The interruption of blood flow to neurological tissues can cause symptoms of confusion, headache, hearing loss, and peripheral neuropathy.