It is currently suggested that agRNA is first loaded and processed by an Ago protein which then guides it to its promoter target, which can be a non-coding transcript overlapping the promoter or the chromosomal DNA.
It is currently suggested that agRNAs are first loaded and processed by an Ago protein to form an Ago-RNA complex which is then guided by the RNA to its promoter target. The target can be a non-coding transcript overlapping the promoter or the chromosomal DNA.