Ginampanan ni Jackson si Propesor Denise Gaines sa The Nutty Professor II: The Klumps, katambal siEddie Murphy. Sinabi ni Brian Grazer, "she's a superstar musician who acts. Getting Janet is a huge coup for us because she doesn't have to do movies, but she wants to do this one." Komento ni Murphy, "I've known for years that she's a good actress. [...] She's a superstar and a really talented woman... It was like 'Wow, I'm with a superstar on the set'." Nagbukas an pelikula na numero uno asin may $ 175 milyon na ganar sa interong kinaban, asin ini an may pinakadakula sa laog nin sarong semana matapos an opening, sa bilong na karera ni Murphy. Nagresibe si Jackson nin pag-umaw sa mga kritiko para sa saiyang pagganap. Sinabi ni Melissa Marschheuser kan The Sentinel na "ginampanan niya ang perpektong papel", mantang inumaw siya ni Variety na "bakong mapanghimok na panghihimok."