Napangaranan siya komo ikaduwang Greatest Male Star of All Time  kan American Film Institute. An mga popular asin mga klasikong pelikula niya nabibilang an She done Him Wrong (1933), Topper (1937), The Awful Truth (1937), Bringing Up Baby (1938), Gunga Din (1939), Only Angels Have Wings (1939), His Girl Friday (1940), The Philadelphia Story (1940), Suspicion(1941)(1941), The Talk of the Town (1942), Arsenic and Old Lace (1944), Notorious (1946), Mr. Blandings Builds His Dream House (1948), To Catch A Thief (1955), An Affair to Remember (1957), North by Northwest (1959), asin Charade (1963).