Des Bistum Knoxville umfosst de im Bundesstoot Tennessee glengna Gebiete: Anderson County, Bledsoe County, Blount County, Bradley County, Campbell County, Carter County, Claiborne County, Cocke County, Cumberland County, Fentress County, Grainger County, Greene County, Hamblen County, Hamilton County, Hancock County, Hawkins County, Jefferson County, Johnson County, Knox County, Meigs County, Pickett County, Unicoi County und Union County.