D'entre a suya filmografía como director, se puet destacar cintas como Night of the Living Dead (1968, con Duane Jones, Judith O'Dea, Karl Hardman, Marilyn Eastman, Keith Wayne, Judith Ridley y Kyra Schon), The Crazies (1973, con Lane Carroll, Will MacMillan, Harold Wayne Jones, Richard Liberty y Lynn Lowry), Day of the Dead (1985, con Lori Cardille, Terry Alexander, Joe Pilato, Jarlath Conroy, Anthony Dileo Jr., Richard Liberty y Sherman Howard), Two Evil Eyes (1990, con Adrienne Barbeau, E.G. Marshall, Harvey Keitel, Madeleine Potter, Martin Balsam y Barbara Bryne), Land of the Dead (2005, con Simon Baker, John Leguizamo, Dennis Hopper y Asia Argento), u Survival of the Dead (2009, con Alan van Sprang, Kenneth Welsh, Kathleen Munroe, Devon Bostick, Richard Fitzpatrick, Athena Karkanis, Stefano Collaciti, Joris Jarsky, Eric Woolfe, Julian Richings y Wayne Robson).