D'entre a suya filmografía como director, se puet destacar as cintas The Maltese Falcon (1941, con Humphrey Bogart, Mary Astor, Gladys George, Peter Lorre y Sydney Greenstreet), The Treasure of the Sierra Madre (1948, con Humphrey Bogart, Walter Huston, Tim Holt y Bruce Bennett), Key Largo (1948, con Humphrey Bogart, Edward G. Robinson, Lauren Bacall, Lionel Barrymore, Claire Trevor y Marc Lawrence), The Asphalt Jungle (1950, con Sterling Hayden, Louis Calhern, Jean Hagen, James Whitmore, Sam Jaffe y Marilyn Monroe), The African Queen (1951, con Humphrey Bogart, Katharine Hepburn y Robert Morley), Moulin Rouge (1952, con José Ferrer, Zsa Zsa Gabor y Suzanne Flon), Heaven Knows, Mr. Allison (1957, con Deborah Kerr y Robert Mitchum), The Night of the Iguana (1964, con Richard Burton, Ava Gardner y Deborah Kerr), The Man Who Would Be King (1975, con Sean Connery, Michael Caine, Christopher Plummer y Saeed Jaffrey), Escape to Victory (1981, con Sylvester Stallone, Michael Caine, Max Von Sydow y Pelé), Under the Volcano (1984, con Albert Finney y Jacqueline Bisset), u Prizzi's Honor (1985, con Jack Nicholson, Kathleen Turner, Robert Loggia y Anjelica Huston).