D'entre a suya muit ampla filmografía, se puet destacar bellas cintas, como Murder! (1930, con Herbert Marshall y Norah Baring), The 39 Steps (1935, con Robert Donat, Madeleine Carroll, Lucie Mannheim y Godfrey Tearle), The Lady Vanishes (1938, con Margaret Lockwood, Michael Redgrave y Paul Lukas), Jamaica Inn (1939, con Charles Laughton, Maureen O'Hara y Emlyn Williams), Rebecca (1940, con Laurence Olivier, Joan Fontaine y Judith Anderson), Suspicion (1941, con Joan Fontaine, Cary Grant, Cedric Hardwicke, Nigel Bruce y May Whitty), Notorious (1946, con Ingrid Bergman, Cary Grant y Claude Rains), I Confess (1953, con Montgomery Clift, Anne Baxter, Karl Malden y Brian Aherne), Dial M for Murder (1954, con Ray Milland, Grace Kelly y Robert Cummings), Vertigo (1958, con James Stewart, Kim Novak y Barbara Bel Geddes), North by Northwest (1959, con Cary Grant, Eva Marie Saint y James Mason), Psycho (1960, con Anthony Perkins, Vera Miles, John Gavin y Janet Leigh), The Birds (1963, con Tippi Hedren, Rod Taylor, Jessica Tandy, Suzanne Pleshette y Veronica Cartwright), u Topaz (1969, con Frederick Stafford, Dany Robin, Claude Jade, Michel Subor u John Forsythe).