D'entre a suya filmografía, se puet destacar as suyas interpretacions en cintas como Mystic Pizza (1988, Donald Petrie), Steel Magnolias (1989, Herbert Ross), Pretty Woman (1990, Garry Marshall), Dying Young (1991, Joel Schumacher), Sleeping with the Enemy (1991, Joseph Ruben), The Pelican Brief (1993, Alan J. Pakula), My Best Friend's Wedding (1997, P. J. Hogan), Runaway Bride (1999, Garry Marshall), Notting Hill (1999, Roger Michell), Erin Brockovich (2000, Steven Soderbergh), Ocean's Eleven (2001, Steven Soderbergh), Closer (2004, Mike Nichols), Charlie Wilson's War (2007, Mike Nichols), u Duplicity (2009, Tony Gilroy).