KERYX BIOPHARMACEUTICALS INC
<DOCUMENT>
<TYPE>EX-10.39
<SEQUENCE>11
<FILENAME>ex1039.htm
<TEXT>
<html>
<head>
<title>Redacted Addendum to License and Coopeation Agreement</title>
</head>
<body>
<p align="right"><b><font size="3" face="Times New Roman">Exhibit 10.39</font></b></p>

<p align="center"><font size="3" face="Times New Roman">OMITTED INFORMATION IS THE SUBJECT OF A REQUEST FOR CONFIDENTIAL TREATMENT PURSUANT
  TO RULE 24B-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 AND HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.</font></p>
<p><font size="3" face="Times New Roman"><b>Addendum Agreement to License and Cooperation Agreement for Perifosine</b></font></p>

<p><font size="3" face="Times New Roman">by and between</font></p>

<p><font size="3" face="Times New Roman">Zentaris GmbH, Weism&uuml;llerstrasse 45, D-60314 Frankfurt am Main</font></p>

<p align="right"><font size="3" face="Times New Roman">- herein "<b>Zentaris</b>"</font></p>

<p><font size="3" face="Times New Roman">and</font></p>

<p><font size="3" face="Times New Roman">AOI Pharma, Inc., 750 Lexington Avenue, 26<sup>th</sup> Floor, New York, New York 10022,
USA</font></p>

<p align="right"><font size="3" face="Times New Roman">- herein "<b>AOI</b>"<b></b>-</font></p>

<p align="right"><font size="3" face="Times New Roman">Zentaris and AOI herein each a "<b>Party</b>"</font></p>

<p align="right"><font size="3" face="Times New Roman">and collectively "<b>Parties</b>"</font></p>

<p><font size="3" face="Times New Roman">regarding pharmaceutical activities for Perifosine to be provided by Zentaris.</font></p>

<p align="center"><b><font size="3" face="Times New Roman">WITNESSETH:</font></b></p>

<p style="text-indent: 60"><font size="3" face="Times New Roman">WHEREAS, AOI and Zentaris have entered into a License Agreement for Perifosine dated
September 18, 2002 regarding the development, manufacturing and commercialization of Perifosine ("License Agreement").&nbsp; This
addendum is made to define the agreement of the Parties with respect to the Pharmaceutical Development of Perifosine API and
Perifosine Drug Product.</font></p>

<table border="1" cellpadding="0" cellspacing="0" style="border-collapse: collapse; border-width: 0" bordercolor="#111111" width="95%">
  <tr>
    <td width="57" style="border-style: none; border-width: medium"><b><font size="3" face="Times New Roman">1.</font></b></td>
    <td width="838" style="border-style: none; border-width: medium"><b><font size="3" face="Times New Roman">Definitions</font></b></td>
  </tr>
  <tr>
    <td width="57" style="border-style: none; border-width: medium">&nbsp;</td>
    <td width="838" style="border-style: none; border-width: medium">&nbsp;</td>
  </tr>
  <tr>
    <td width="57" style="border-style: none; border-width: medium">&nbsp;</td>
    <td width="838" style="border-style: none; border-width: medium"><font size="3" face="Times New Roman">The terms employed in this addendum shall have the same meaning as specified in Section 1
of the License Agreement. Additional terms are defined as follows:</font></td>
  </tr>
</table>
<font size="2" face="Times New Roman"><hr size="1" color="#C0C0C0" STYLE="page-break-after: always"></font>

<p>&nbsp;</p>

<table border="0" cellpadding="7" cellspacing="0" style="border-collapse: collapse" bordercolor="#111111" width="95%">
  <tr>
    <td width="54" valign="top"><font size="3" face="Times New Roman">1.1</font></td>
    <td width="841"><font size="3" face="Times New Roman"> <b>"CMC Representatives"</b> shall mean the
personnel designated by each party (refer to &sect; 4) to make decision on tasks and timing required for Pharmaceutical Development
of Perifosine.</font></td>
  </tr>
  <tr>
    <td width="54" valign="top"><font size="3" face="Times New Roman">1.2</font></td>
    <td width="841"><font size="3" face="Times New Roman"> <b>"Development
Services"</b> shall mean and include certain activities to execute the plan for Pharmaceutical Development as herein appended or as
subsequently modified by the Parties, or to produce Perifosine API and/or Drug Product for use in clinical trials.&nbsp; The
Parties agree that such Development Services shall be provided by Zentaris unless Zentaris delegates certain Development Services
to AOI or such Development Services which have to be provided by AOI for regulatory purposes.</font></td>
  </tr>
  <tr>
    <td width="54" valign="top"><font size="3" face="Times New Roman">1.3</font></td>
    <td width="841"><font size="3" face="Times New Roman"> <b>"Pharmaceutical
Development"</b> shall mean and include all tasks and activities performed for the purpose of obtaining CMC (Chemistry,
Manufacturing &amp; Controls) Development Data suitable for regulatory approval, and a robust and economical manufacturing process
capable of meeting quality control targets at commercial production volumes.&nbsp; As such, it includes, but is not limited to the
activities of process and formulation development, scale-up trials and production of drug materials for use in clinical trials,
equipment and process validation, qualification of materials, stability and compatibility testing of the API and Drug Product, as
well as development and validation of analytical methodology necessary to process validation and product release
testing.</font></td>
  </tr>
  <tr>
    <td width="54" valign="top"><b><font size="3" face="Times New Roman">2.</font></b></td>
    <td width="841"><b><font size="3" face="Times New Roman">Development
Services of Zentaris</font></b></td>
  </tr>
  <tr>
    <td width="54" valign="top"><font size="3" face="Times New Roman">2.1</font></td>
    <td width="841"><font size="3" face="Times New Roman">Zentaris and AOI shall jointly be responsible for
the Pharmaceutical Development of Perifosine.&nbsp; The initial Development Services to be performed by Zentaris, including the
estimated time lines for such Development Services, are described in <u>Table 1</u> hereto.&nbsp; Any further Pharmaceutical
Development hereunder shall be agreed first between the CMC Representatives of both Parties and finally in the Co-Ordination
Committee in accordance with Sections 5.2 et seq. of the License Agreement, provided, however, that neither party shall have the
casting vote regarding the Pharmaceutical Development and the Development Services unless either Party can demonstrate to the
reasonable satisfaction of the other Party, that such Pharmaceutical Development and Development Services are (or, alternatively,
are not) required for regulatory or economical manufacturing purposes.</font></td>
  </tr>
  <tr>
    <td width="54" valign="top"><font size="3" face="Times New Roman">2.2</font></td>
    <td width="841"><font size="3" face="Times New Roman">Each Party is entitled - in its own discretion -
to employ subcontractors to perform the Development Services hereunder.</font></td>
  </tr>
  <tr>
    <td width="54" valign="top"><font size="3" face="Times New Roman">2.3</font></td>
    <td width="841"><font size="3" face="Times New Roman">The estimated costs for Zentaris to perform
specified Development Services are indicated in <u>Table 2</u> hereto.&nbsp; The assumptions on which these estimates are based are
indi&shy;cated in the Appendix below.&nbsp; The actual costs of the Development Services performed by Zentaris or AOI hereunder
regarding the Pharmaceutical Development (including API costs) will be shared [**]%</font>&nbsp; by each Party except for the packaging, labelling and final release of study
medication requested by a Party to perform clinical studies, which will be paid for by the requesting Party.&nbsp; <u>Table 3</u>
gives an overview of estimated costs to AOI for packaging, labelling and final release of specific study medication according to
the general project plan.&nbsp; In the event that Development Services exceed the estimate by more than [*******] percent ([**]%),
the reason for the excess will be explained according to Section 2.9 below.</td>
  </tr>
</table>

<p>____________________________________<br>
*Omitted information is the subject of a request for confidential treatment
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934 and has been
filed separately with the Securities and Exchange Commission</p>

<font size="2" face="Times New Roman"><hr size="1" color="#C0C0C0" STYLE="page-break-after: always"></font>

<table border="0" cellpadding="7" cellspacing="0" style="border-collapse: collapse" bordercolor="#111111" width="95%">
  <tr>
    <td width="54" valign="top"><font size="3" face="Times New Roman">2.4</font></td>
    <td width="841"><font size="3" face="Times New Roman">Fees payable by AOI to Zentaris for Development
Services rendered will be invoiced according to <u>Table 2</u>.&nbsp; VAT, if any, will be invoiced separately.&nbsp; All invoices
are payable within thirty (30) days of the date of the invoice.&nbsp; Where applicable, currency exchange shall be made at the
7-day moving average (centered on the invoice date) interbank rate cited at <u><font color="blue">http://www.oanda.com</font></u>
(or other reference as subsequently agreed by the parties).&nbsp; Fees payable to AOI shall be made on the same basis.</font></td>
  </tr>
  <tr>
    <td width="54" valign="top"><font face="Times New Roman">2.5</font></td>
    <td width="841"><font size="3" face="Times New Roman">The costs of the Development Services not included
in <u>Table 1</u> shall be the sum of direct expenses and the cost of Zentaris resources, compensated on an hourly basis in
accordance with Zentaris' applicable standard rate.&nbsp; This standard rate is &euro; [***]</font>&nbsp; per hour for the year 2003, and may be adjusted annually to reflect
increases in labour and operating costs.&nbsp; The new hourly rate for the subsequent year(s) will be referenced to
industry-specific inflation rates and communicated to AOI on or before December 31 of the preceding year.&nbsp; The invoicing of
additional costs will be performed according to &sect;2.3 and 2.4.</td>
  </tr>
  <tr>
    <td width="54" valign="top"><font face="Times New Roman">2.6</font></td>
    <td width="841"><font size="3" face="Times New Roman">&nbsp;The tasks and timing for the Pharmaceutical
Development of Perifosine, including estimates of Zentaris resource requirements for Development Services performed under
subsection 2.5, will be reviewed by the CMC Representatives from time to time both independently and in conjunction with the
meeting of the Co-Ordination Committee. Changes to the approved Pharmaceutical Development plan Table 1) have to be mutually agreed
by the Parties, according to the conditions of Section 5 of the License Agreement.&nbsp; The Parties will make their best
reasonable effort to formally issue a revised plan for the Pharmaceutical Development within 14 business days of the program
review. The Parties may agree on further Development Services (in addition to the Development Services in Table 1) to be performed
by Zentaris for the Pharmaceutical Development, including tasks, timing and fees, for up to the subsequent 12 months.</font></td>
  </tr>
  <tr>
    <td width="54" valign="top"><font face="Times New Roman">2.7</font></td>
    <td width="841"><font size="3" face="Times New Roman">Both Parties appoint
    the persons listed in &#167;4 hereto as CMC Representatives to be contacted on
    all pharmaceutical and technical questions.&nbsp; Each Party shall inform
    the other Party in writing about any replacement.</font></td>
  </tr>
</table>

<p>____________________________________<br>
*Omitted information is the subject of a request for confidential treatment
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934 and has been
filed separately with the Securities and Exchange Commission</p>

<font size="2" face="Times New Roman"><hr size="1" color="#C0C0C0" STYLE="page-break-after: always"></font>

<table border="0" cellpadding="7" cellspacing="0" style="border-collapse: collapse" bordercolor="#111111" width="95%">
  <tr>
    <td width="54" valign="top">2.8</td>
    <td width="841"><font size="3" face="Times New Roman">Each Party shall bear
    its own costs for normal business interactions related to this agreement,
    including, without limitation, communications, business reviews/meetings of
    the Coordination Committee, and travel and living expenses.</font></td>
  </tr>
  <tr>
    <td width="54" valign="top">2.9</td>
    <td width="841"><font size="3" face="Times New Roman">Zentaris shall report on the Development Services
performed and any development results achieved to the CMC Representative from AOI as listed under &sect;4.&nbsp; Reports will be
submitted as indicated in Table 2.</font></td>
  </tr>
  <tr>
    <td width="54" valign="top"><b>3.</b></td>
    <td width="841"><b><font size="3" face="Times New Roman">Intellectual
    Property</font></b></td>
  </tr>
  <tr>
    <td width="54" valign="top">3.1</td>
    <td width="841"><font size="3" face="Times New Roman">Since AOI and Zentaris are partners in the
Pharmaceutical Development of perifosine, all Improvements and Inventions and any other data, information and invention generated
in the course of or as a result of the Development Services shall be the joint property of AOI and Zentaris, each of whom shall
have a one-half pro indiviso share.&nbsp; Joint patent rights shall be filed in the name of both Parties and assigned by the
inventors to both Parties.&nbsp; Both Parties shall be free to use such jointly owned inventions, to grant sublicenses and assign
such jointly owned inventions, subject to the confidentiality obligations under Section 6 of the License Agreement and subject to
the rights and limitations as defined in Section 7 of the License Agreement.</font></td>
  </tr>
  <tr>
    <td width="54" valign="top"><b>4.</b></td>
    <td width="841"><b><font size="3" face="Times New Roman">CMC Representatives</font></b></td>
  </tr>
  <tr>
    <td width="54" valign="top">&nbsp;</td>
    <td width="841"><font size="3" face="Times New Roman">The following persons
    will stay in contact to communicate, discuss and decide about all
    pharmaceutical aspects in the development of the API and final dosage form:</font><p><font size="3" face="Times New Roman">William Bennett (AOI)<br>
    Tel.:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; +1 203 406 1725 ext. 2509<br>
    Fax:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; +1 203 406 1726</font></p>

<p><font size="3" face="Times New Roman">Mobile:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; +l 908 230
7370</font></p>

<p><font size="3" face="Times New Roman">&nbsp;</font></p>

<p><font size="3" face="Times New Roman">Dr. Matthias Rischer (Zentaris)<br>
Tel.:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; + 49 69 42602 3431<br>
Fax:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; + 49 69 42602 3413<br>
Mobile:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; + 49 173 676
7262</font></p>

    </td>
  </tr>
  <tr>
    <td width="54" valign="top"><b>5.</b></td>
    <td width="841"><b><font size="3" face="Times New Roman">Term and
    Termination</font></b></td>
  </tr>
  <tr>
    <td width="54" valign="top">5.1</td>
    <td width="841"><font size="3" face="Times New Roman">After the first year
    of this agreement, either party may terminate this addendum agreement upon
    ninety days written notice to the other Party.&nbsp; After the termination
    notice is issued, the parties shall review the Pharmaceutical Development
    program and terminate any further Pharmaceutical Development activities.&nbsp;
    Any expenses that can not be terminated shall be handled according to
    Section 2 of this agreement.</font></td>
  </tr>
</table>
<font size="2" face="Times New Roman"><hr size="1" color="#C0C0C0" STYLE="page-break-after: always"></font>

<blockquote>

<p>&nbsp;<font size="3" face="Times New Roman">IN WITNESS WHEREOF, the
parties have caused this Agreement to be executed this <u>3<sup>rd</sup></u> day of <u>December</u>, 2003, by their duly authorized
representatives.</font></p>

</blockquote>

<p><font size="3" face="Times New Roman"></font></p>

<table border="0" cellspacing="0" cellpadding="0" width="734">
<tr>
<td valign="top" width="367">
<h1><b><u><font size="3" face="Times New Roman">Zentaris GmbH</font></u></b></h1>
</td>
    <td width="367" align="left" valign="top">
      <p align="left"><u><font size="3" face="Times New Roman">AOI Pharma, Inc.</font></u></p>
</td>
</tr>

<tr>
<td valign="top" width="367"></td>
<td valign="top" width="367"></td>
</tr>

<tr>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">By:&nbsp; <u>&nbsp;&nbsp;&nbsp;&nbsp; /s/ Matthias
Rischer&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">By:&nbsp;&nbsp;&nbsp;&nbsp; <u>&nbsp;
/s/ Michael S. Weiss&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
</tr>

<tr>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">Name: <u>Matthias
Rischer&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">Name: <u>Michael S.
Weiss&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
</tr>

<tr>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">Title:&nbsp; <u>&nbsp; Vice
President&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">Title:&nbsp; <u>&nbsp;
Chairman&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
</tr>

<tr>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">Date: <u>&nbsp;&nbsp; 12/5/2003
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">Date:&nbsp; <u>&nbsp;
12/3/03&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
</tr>

<tr>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">By:&nbsp;&nbsp;&nbsp;&nbsp; <u>&nbsp;&nbsp; /s/ Matthias
Seeber&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
<td valign="top" width="367"></td>
</tr>

<tr>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">Name: <u>Matthias Seeber
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
<td valign="top" width="367"></td>
</tr>

<tr>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">Title:&nbsp; <u>&nbsp; Managing
Director&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
<td valign="top" width="367"></td>
</tr>

<tr>
<td valign="top" width="367">
<p><font size="3" face="Times New Roman">Date:&nbsp; <u>&nbsp;
12/5/03&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>
</td>
<td valign="top" width="367"></td>
</tr>
</table>

</body>
</html>

</TEXT>
</DOCUMENT>
