OSI PHARMACEUTICALS INC
EX-10.5: CONSULTING AGREEMENT
<DOCUMENT>
<TYPE>EX-10.5
<SEQUENCE>4
<FILENAME>y37931exv10w5.htm
<DESCRIPTION>EX-10.5: CONSULTING AGREEMENT
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<TITLE>EX-10.5</TITLE>
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<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CONFIDENTIAL MATERIALS OMITTED AND FILED SEPARATELY WITH THE<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
ASTERISKS DENOTE OMISSIONS</B>
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<DIV align="right" style="font-size: 10pt; margin-top: 12pt"><B>EXHIBIT 10.5</B>
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CONSULTING AGREEMENT</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Consulting Agreement (&#147;<B>Agreement</B>&#148;) is signed on April&nbsp;28, 2006 and effective as of May&nbsp;2,
2006 (&#147;<B>Effective Date</B>&#148;) by and between OSI Pharmaceuticals, Inc., a Delaware corporation (together
with its affiliates and subsidiaries, &#147;<B>OSI</B>&#148;), having executive offices at 41 Pinelawn Road,
Melville, New York 11747, and David Guyer (&#147;<B>Consultant</B>&#148;)<B>, </B>having an address at **.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>1. CONSULTING SERVICES.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The initial phase of the Term (as defined in Section&nbsp;13 hereof) shall commence on the
Effective Date and continue until the day immediately prior to the first anniversary of the
Effective Date and shall be referred to herein as the &#147;Transition Phase&#148;. The period commencing
with the first anniversary of the Effective Date and continuing through the remainder of the Term
shall be referred to herein as the &#147;Consulting Period&#148;. Consultant shall provide consulting
services to OSI during the Term as follows:
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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(a)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>During the Transition Phase, Consultant shall provide advice and
consultation to, as needed and reasonably requested by, OSI and its subsidiary, (OSI)
Eyetech, Inc. (&#147;(OSI) Eyetech&#148;) regarding the business and operations of (OSI)&nbsp;Eyetech
so as to facilitate an orderly transition of the duties and responsibilities undertaken
by Consultant prior to the Effective Date in his role as head of the (OSI)&nbsp;Eyetech
business to his successor in such role. Consultant will be available to provide such
Services not less than <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></SUP> days per month for this purpose during the
Transition Phase.</TD>
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</TABLE>
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<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></TD>
    <TD>&nbsp;</TD>
    <TD>This portion has been redacted pursuant to a confidential treatment request.</TD>
</TR>

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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(b)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>During the Transition Phase and during the Consulting Period, Consultant
will provide advice and consultation to, as needed and reasonably requested by, the
Board of Directors of OSI and the CEO and other members of senior management of OSI
relating to the field of ophthalmology. In addition, during the Term, Consultant will
serve as a technical advisor to the eye disease subcommittee of the OSI Board of
Directors. Consultant will be available to provide such Services not less <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></SUP> days per month during the Term.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(c)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The services described in subsection (a)&nbsp;and subsection (b)&nbsp;above shall be collectively referred to herein as the &#147;Services.&#148;</TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>2. DELIVERY OF CONSULTING SERVICES.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Consultant will carry out the Services to the best of Consultant&#146;s ability in a professional
manner consistent with industry standards, in accordance with the standard of care customarily
observed with regard to such services in Consultant&#146;s profession and using the Consultant&#146;s
expertise and creative talents. Consultant will perform the Services in a timely manner and at a
location, time and place that Consultant deems appropriate. Consultant will perform the Services
in compliance with all applicable laws, rules and regulations.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>3. COMPENSATION AND REIMBURSEMENT.</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(a)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>During the Transition Phase, OSI shall pay Consultant an annual retainer of
$775,000 which shall be due and payable in two equal installments on November&nbsp;2, 2006
and May&nbsp;2, 2007. During the Consulting Period, OSI shall pay Consultant an annual
retainer of $250,000 which shall be due and payable in two</TD>
</TR>

</TABLE>
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<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
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<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></TD>
    <TD>&nbsp;</TD>
    <TD>This portion has been redacted pursuant to a confidential treatment request.</TD>
</TR>

</TABLE>


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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>equal installments on the anniversaries of the payment dates during the Transition Phase.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(b)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>OSI will reimburse Consultant for reasonable out-of-pocket expenses incurred
in connection with the Consultant&#146;s performance of the Services upon the presentation
of receipts for such expenses. To the extent feasible, Consultant will use
OSI-designated travel services to make all OSI requested travel arrangements.</TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>4. USE OF OFFICE AND SUPPORT STAFF.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;During the Term, OSI shall provide to Consultant the use of an office at OSI&#146;s Times Square
facility or another OSI facility mutually agreed upon by Consultant and OSI; provided, however,
that the foregoing shall in no way obligate OSI to maintain a facility in New York City for the
duration of the Term. During the Term, OSI shall also provide to Consultant administrative support
services mutually agreed upon by OSI and Consultant.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>5. CONFIDENTIALITY.</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(a)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>&#147;<B>Confidential Information</B>&#148; means confidential or proprietary information of
OSI either disclosed orally, graphically, in writing, or in electronic or other form to
or otherwise learned by Consultant during the course of his employment by OSI and (OSI)
Eyetech and under this Agreement or that should reasonably be known by Consultant to be
confidential or proprietary to OSI, including but not limited to information relating
to OSI&#146;s research, development, preclinical and clinical programs, data and results;
product candidates and products; inventions, works of authorship, trade secrets,
processes, conceptions, formulas, patents, patent applications and licenses; IP Rights
(as defined in Section&nbsp;8); business, product, marketing, sales, scientific and
technical strategies, programs and results, </TD>
</TR>

</TABLE>
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<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR valign="top" style="font-size: 10pt; color: #textcolor#; background: #bgcolor#">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>including costs and prices; suppliers,
manufacturers, customers, market data, personnel, and consultants; and other
confidential matters related to OSI, but not including Consultant&#146;s general knowledge
and know how.</TD>
</TR>

</TABLE>
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<DIV style="margin-top: 6pt">
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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(b)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Subject to Section&nbsp;5(c), until <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></SUP> years after the
expiration or termination of this Agreement, Consultant:</TD>
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<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="6%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(i)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>shall not use Confidential Information for his own benefit or the
benefit of any third party except solely for the purpose of performing
Services;</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="6%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(ii)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>shall hold Confidential Information in strictest confidence and
shall not disclose Confidential Information to others;</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="6%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(iii)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>shall use reasonable efforts to protect the confidentiality of
Confidential Information; and</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="6%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(iv)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>shall notify OSI as promptly as practicable of discovery of any
unauthorized use or disclosure of Confidential Information.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(c)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Consultant&#146;s obligations under Section 5(b) shall not apply to any
Confidential Information that:</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="6%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(i)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>is now, or becomes in the future, publicly available other than by
an act or omission of Consultant in violation of this Section&nbsp;5;</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="6%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(ii)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>a third party discloses to Consultant, without any legal
restriction on disclosure known to Consultant, and without any breach of any direct or indirect obligation of confidentiality to OSI
known to Consultant; or</TD>
</TR>

</TABLE>
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></TD>
    <TD>&nbsp;</TD>
    <TD>This portion has been redacted pursuant to a confidential treatment request.</TD>
</TR>

</TABLE>


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<DIV style="font-family: 'Times New Roman',Times,serif">











<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="6%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(iii)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>was or is independently developed by Consultant or others on
Consultant&#146;s behalf without using any Confidential Information or violating any
of Consultant&#146;s obligations under this Agreement.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(d)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Notwithstanding other provisions of this Agreement, Consultant may disclose
Confidential Information to the extent and to the persons or entities required under
applicable governmental law, rule, regulation or order, provided that Consultant (i)
first gives prompt notice of such disclosure requirement to OSI so as to enable OSI to
seek any limitations on or exemptions from such disclosure requirement and (ii)
reasonably cooperates at OSI&#146;s request in any such efforts by OSI, at OSI&#146;s
expense.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(e)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Upon the earlier of the completion of the Services or OSI&#146;s request for any
reason at any time, Consultant will (i)&nbsp;immediately cease all commercial use of
Confidential Information and notify OSI and (ii)&nbsp;promptly, at OSI&#146;s instruction, either
return to OSI or destroy all Confidential Information that exists in tangible form,
including destroying (but not returning to OSI) any copies, extracts, summaries, or
derivative works thereof, and certify in writing to OSI the completion of such return
and/or destruction.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(f)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>OSI retains all right, title and interest in and to Confidential
Information. This Agreement gives Consultant no right or license to any Confidential
Information or any intellectual property or other rights owned by or licensed to OSI,
by implication or otherwise, except the right to use Confidential Information solely
for performance of Services. OSI may freely transfer, disclose and/or use Confidential
Information for its or others&#146; purposes.</TD>
</TR>

</TABLE>
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<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">



</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>6. CERTAIN AGREEMENTS.</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(a)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>During the Term, Consultant shall not serve as an employee of, or consultant
to, or owner of more than <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></sup> of the equity of, any company that is a
Competing Business at the time Consultant serves in such capacity. For purposes of
this Agreement, &#147;Competing Business&#148; means (i)&nbsp;during the period beginning on the
Effective Date and ending on the first anniversary of the Effective Date, any company
that <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></sup> of <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></sup>, (ii)&nbsp;during the period beginning on the first anniversary of the
Effective Date and ending on the second anniversary of the Effective Date, any
company that <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></sup> and (iii)&nbsp;at any time during the Term, any company that <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></sup>. For the
avoidance of doubt, <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></sup>.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(b)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>During the Term, Consultant shall not, individually or on behalf of or
through any third party, directly or indirectly, (i)&nbsp;solicit, entice or persuade or
attempt to solicit, entice or persuade any employees of or consultants to OSI to leave
the service of OSI for any reason, or employ, cause to be employed, or solicit the
employment of, any employees of or consultants to OSI while any such person is
providing services to OSI, or (ii)&nbsp;solicit, divert or appropriate or attempt to
solicit, divert or appropriate, any customers of OSI&#146;s Eye Business for the purpose of
directly competing with OSI&#146;s Eye Business. For purposes of this Section&nbsp;6, &#147;Eye
Business&#148; shall specifically refer to <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></sup>.</TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>7. INJUNCTIVE RELIEF.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Consultant expressly acknowledges that any breach or threatened breach of any of the terms
and/or conditions set forth in Sections&nbsp;5 and 6 of this Agreement will result in substantial,
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></TD>
    <TD>&nbsp;</TD>
    <TD>This portion has been redacted pursuant to a confidential treatment request.</TD>
</TR>

</TABLE>


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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">continuing and irreparable injury to OSI. Therefore, in addition to any other remedy that may be
available to OSI, OSI will be entitled to injunctive or other equitable relief by a court of
appropriate jurisdiction in the event of any breach or threatened breach of the terms of Sections&nbsp;5
and 6 of this Agreement.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>8. INTELLECTUAL PROPERTY.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Consultant hereby assigns to OSI all of Consultant&#146;s right, title and interest in and to any
intellectual property rights arising from inventions, software programs, databases or other
discoveries made, conceived, reduced to practice, authored or otherwise developed solely or jointly
by Consultant or any of Consultant&#146;s employees or agents in whole or in part through use of
Confidential Information or in the course of performing Services (&#147;<B>IP Rights</B>&#148;). Consultant hereby
grants OSI an irrevocable power of attorney to execute on Consultant&#146;s behalf patent and copyright
applications or other such documents required to protect, enforce or perfect OSI&#146;s right, title and
interest in and to such IP Rights.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>9. PUBLICATION.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Consultant agrees that, during the term of this Agreement and for a period of <SUP style="font-size: 85%; vertical-align: text-top"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></sup>
years from termination of this Agreement, if for any reason Consultant wishes to present or publish
scientific articles or papers concerning Consultant&#146;s own research work, the content of which is
based on Confidential Information first received from OSI, Consultant shall submit such proposed presentations, articles and papers to
OSI for its review and possible action to protect OSI&#146;s patent rights at least <SUP style="font-size: 85%; vertical-align: text-top">**</sup> days prior to the
publication or disclosure date. OSI will promptly review Consultant&#146;s proposed presentations or
publications.<SUP style="font-size: 85%; vertical-align: text-top">**</sup>
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></TD>
    <TD>&nbsp;</TD>
    <TD>This portion has been redacted pursuant to a confidential treatment request.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->7<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">






<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>10. REPRESENTATION AND WARRANTIES.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Consultant represents and warrants to OSI that:
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(a)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Consultant has the full right, power and authority to enter into this
Agreement and perform its obligations hereunder without the consent of any third party
and without breach of any agreements with or obligations to any third party;</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(b)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Consultant will not grant, transfer, assign or convey, directly or
indirectly, any right, title or interest in or to any IP Rights to any third party;</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(c)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Consultant has not entered and will not enter into any agreement with or
obligation to a third party inconsistent, incompatible, or conflicting with its
obligations under this Agreement; and</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(d)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Consultant will inform OSI immediately of any contracts or subject matter
with which Consultant or members of Consultant&#146;s family are engaged in that may in any
way raise a conflict of interest between Consultant and OSI.</TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>11. INDEMNIFICATION.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each party will defend, indemnify and hold harmless the other party, its officers, directors,
employees and agents from and against any and all losses, liabilities, damages, expenses and costs
(including reasonable attorney&#146;s fees) (&#147;<B>Losses</B>&#148;) directly caused by or resulting from a material
breach of this Agreement by such party, except to the extent such Loss was caused by the gross
negligence or willful misconduct of the party (including its officers, directors, employees and
agents) seeking indemnification. Each party will notify the other party promptly upon learning of
a claim, demand, suit, or proceeding of which it is aware that would reasonably be expected to give
rise to a Loss, and the potentially indemnifying party may control defense and settlement thereof
provided it does so diligently, in good faith and using reasonably
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->8<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">experienced counsel with
expertise in the relevant field. The potentially indemnified party will reasonably cooperate in
such defense and/or settlement at the potentially indemnifying party&#146;s request and expense and may
participate at its own expense using its own counsel.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>12. WAIVER AND RELEASE.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Except with respect to compensation set forth in Section&nbsp;3, Consultant hereby waives, fully
releases and forever discharges OSI and its agents, employees, successors and assigns from and
against any and all demands, claims, actions, causes of action, rights, suits, covenants, contracts
and agreements of any kind, known or unknown, absolute or contingent, determined or speculative,
both in law and in equity, brought or made by or on behalf of Consultant, arising out of
Consultant&#146;s services under and pursuant to the Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>13. TERM AND TERMINATION.</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(a)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The term of this Agreement shall commence on the Effective Date and expire
on the fourth anniversary of the Effective Date (the &#147;Term&#148;) unless earlier terminated
under this Section&nbsp;13.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(b)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Either party may terminate this Agreement for a material breach by the other
party upon <SUP style="font-size: 85%; vertical-align: text-top">**</sup> days&#146; written notice specifying the breach unless such
breach is cured within such <SUP style="font-size: 85%; vertical-align: text-top">**</sup> day period.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(c)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Consultant may terminate this Agreement at any time and for any reason
upon <SUP style="font-size: 85%; vertical-align: text-top">**</sup> days&#146; written notice to OSI.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(d)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Expiration or termination of this Agreement shall not affect accrued rights
or obligations of the parties. Sections&nbsp;5, 7, 8, 9, 10(c), 10(d), 10(e), 11, 12, 13(d),
15, 16, 17 and 18 shall survive termination or expiration of this Agreement.</TD>
</TR>

</TABLE>
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></TD>
    <TD>&nbsp;</TD>
    <TD>This portion has been redacted pursuant to a confidential treatment request.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->9<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">






<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>14. CHANGE OF CONTROL.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Upon a &#147;Change of Control&#148; of OSI, all amounts remaining to be paid to Consultant under this
Agreement shall become immediately due and payable and this Agreement shall terminate. &#147;Change of
Control shall be defined as <SUP style="font-size: 85%; vertical-align: text-top">**</sup> .
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>15. STOCK OPTIONS.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Consultant&#146;s stock options to acquire common stock of OSI shall not terminate as a result
of the termination of Consultant&#146;s employment with OSI and commencement of this consulting
arrangement, but instead shall continue to vest during the Term on the same terms as they would
have vested if Consultant had remained employed by OSI during such time period.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>16. ACKNOWLEDGEMENT.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;OSI acknowledges that Consultant intends to commence immediately a relationship, which may be
as a partner, consultant, advisor, employee, or in some other capacity, with SV Life Sciences.
Without limiting the generality of the foregoing, OSI acknowledges that Consultant may, during the
Term, (i)&nbsp;serve as an employee or partner of, or consultant to, any venture capital firm or other
institutional investor, (ii)&nbsp;assist in the evaluation of investment opportunities by any venture
capital firm or other institutional investor, and (iii)&nbsp;serve on the board of directors of, or as
an employee of or consultant to, any company that is not a Competing Business. In particular, the
Consultant has advised OSI that he may, and OSI acknowledges that Consultant may, join the board of
directors of each of Optos plc, a retinal imaging company, and NeoVista, Inc., a company developing
a radiation probe device for macular degeneration.
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></TD>
    <TD>&nbsp;</TD>
    <TD>This portion has been redacted pursuant to a confidential treatment request.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->10<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">






<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>17. INDEMNITY.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;From the Effective Date through the sixth anniversary of the last day of the Term, OSI and
(OSI)&nbsp;Eyetech shall jointly and severally indemnify the Consultant, and hold the Consultant
harmless against, all claims, losses, liabilities, damages, judgments, fines and reasonable fees,
costs and expenses, including attorneys&#146; fees and disbursements, incurred in connection with any
claim, action, suit, proceeding or investigation, whether civil, criminal, administrative or
investigative, arising out of or by reason of the fact that the Consultant is or was an officer,
director, employee or agent of OSI or any of its subsidiaries, to the fullest extent permitted
under Delaware law. OSI shall pay all expenses, including reasonable attorneys&#146; fees, that may be
incurred by the Consultant in connection with his enforcement of his rights provided in this
Section&nbsp;17. The provisions of this Section&nbsp;17 are intended to be in addition to the rights
otherwise available to the Consultant by law, charter, bylaw or agreement, and shall operate for
the benefit of, and shall be enforceable by, the Consultant and his heirs and representatives.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>18. GENERAL.</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(a)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>This Agreement shall be interpreted and enforced in accordance with the laws
of the State of New York, regardless of any choice of law principles that would cause
the application of the law of any other jurisdiction. The parties will submit any
dispute or claim arising under this Agreement to the exclusive jurisdiction of the U.S.
federal or New York state courts within the counties of New York or Suffolk, and the
parties hereby submit to, and waive any objection to, personal jurisdiction and venue
in such courts for such purpose.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(b)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Any purported assignment or delegation by Consultant of this Agreement in
whole or in part without the prior written consent of OSI
shall be void. OSI has </TD>
</TR>

</TABLE>
</DIV>
<P align="center" style="font-size: 10pt"><!-- Folio -->11<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR valign="top" style="font-size: 10pt; color: #textcolor#; background: #bgcolor#">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>the unconditional right to assign this Agreement if
there is no resulting material change in the scope of the Services. This Agreement
shall be binding upon the parties, their successors and their permitted assigns.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(c)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>All notices under this Agreement shall be in writing and shall be deemed
given upon personal delivery, delivery by internationally- or nationally-recognized
bonded courier service, or seven days after sending by certified or registered mail,
postage prepaid and return receipt requested, to the following addresses of the
respective parties or such other address as given by notice under this Section
18(c):</TD>
</TR>

</TABLE>
</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="10%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="85%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:45px; text-indent:-0px">OSI:
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">OSI Pharmaceuticals, Inc.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">At the address set forth at the beginning of this Agreement</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Attention: General Counsel</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:45px; text-indent:-0px">Consultant:
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">David Guyer</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">At the address set forth at the beginning of this Agreement</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(d)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>During the Term, Consultant agrees to abide by the terms of OSI&#146;s
insider trading policy attached hereto as Exhibit&nbsp;A; provided, however, that Consultant
may enter into a trading plan compliant with Rule&nbsp;10b5-1 under the Securities Exchange
Act of 1934 providing for a sale by Consultant of securities of OSI at times that would
otherwise be prohibited by OSI&#146;s insider trading policy.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(e)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>During the term of this Agreement, Consultant will not improperly use or
disclose to OSI any proprietary information or trade secrets of any former or
concurrent employer or other person or entity.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(f)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Consultant recognizes that OSI has received and in the future will receive
from third parties their confidential or proprietary information subject to a duty on
OSI&#146;s part to maintain the confidentiality of such information and to use it only </TD>
</TR>

</TABLE>
</DIV>
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</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR valign="top" style="font-size: 10pt; color: #textcolor#; background: #bgcolor#">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>for certain limited purposes. Consultant agrees to hold all such confidential or
proprietary information in the strictest confidence and not to disclose it to any
person, firm or corporation or to use it except as necessary in carrying out
Consultant&#146;s work for OSI consistent with the OSI&#146;s agreement with such third
party.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(g)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>This Agreement sets forth the complete, final and exclusive agreement
between the parties and supersedes and terminates all prior written and oral agreements
and understandings between Consultant, on the one hand, and OSI and its subsidiaries,
including (OSI)&nbsp;Eyetech, on the other hand, other than the stock option agreements
between OSI and Consultant. No amendment to, or waiver of right under, this Agreement is
effective unless in writing signed by authorized representatives of the parties. No
waiver by a party of any breach of this Agreement shall be a waiver of any preceding
or succeeding breach. No waiver by a party of any right under this Agreement shall
be construed as a waiver of any other right. If any provision of this Agreement is
judicially or administratively determined to be unenforceable, the provision will be
reformed to most nearly approximate the parties&#146; original intent, but otherwise this
Agreement will continue in full force and effect.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(h)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Consultant&#146;s relationship with OSI will be that of an independent
contractor, and nothing in this Agreement shall be construed to create a partnership,
joint venture, or employer-employee relationship. Consultant is not the agent of OSI
and is not authorized to make any representation, contract, or commitment on behalf of
OSI. Consultant will be solely responsible for all tax returns and payments required
to</TD>
</TR>

</TABLE>
</DIV>
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</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR valign="top" style="font-size: 10pt; color: #textcolor#; background: #bgcolor#">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>be filed with or made to any federal, state or local tax authority with respect to
Consultant&#146;s performance of services and receipt of fees under this Agreement.
Consultant will not be entitled to any of the benefits that OSI may make available to
OSI employees, such as group insurance, profit-sharing or retirement benefits. OSI
will regularly report amounts paid to Consultant by filing Form 1099-MISC with the
Internal Revenue Service as required by law, and OSI will not withhold or make payments
for social security, make unemployment insurance or disability insurance contributions,
or obtain worker&#146;s compensation insurance on Consultant&#146;s behalf. Consultant accepts
exclusive liability for complying with all applicable state and federal laws governing
self-employed individuals, including obligations such as payment of taxes, social
security, disability and other contributions based on fees paid to Consultant, its
agents or employees under this Agreement, and will defend, indemnify and hold harmless
OSI from and against any and all such taxes or contributions, including penalties and
interest.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(i)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>This Agreement may be executed simultaneously in two or more counterparts,
each of which shall be deemed an original, but all of which together shall constitute
one and the same instrument.</TD>
</TR>

</TABLE>
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->14<!-- /Folio -->
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The parties hereto have entered into this Agreement as of the Effective Date by their duly
authorized representatives.
</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="8%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="45%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top">/s/</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" valign="top" align="left"><B>OSI PHARMACEUTICALS, INC.</B></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
David Guyer
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(Consultant)</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Social Security Number
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">/s/</TD>
</TR>
<TR style="font-size: 1px">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></TD>
    <TD>&nbsp;</TD>
    <TD>This portion has been redacted pursuant to a confidential treatment request.</TD>
</TR>

</TABLE>



<DIV align="center" style="font-size: 10pt; margin-top: 18pt">&#091;Signature page to consulting agreement&#093;
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B><U>Exhibit&nbsp;A</U></B><SUP style="font-size: 85%; vertical-align: text-top">**</sup>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">**</sup></TD>
    <TD>&nbsp;</TD>
    <TD>This portion has been redacted pursuant to a confidential treatment request.</TD>
</TR>

</TABLE>




<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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