NOVEN PHARMACEUTICALS INC
EX-10.1 LETTER AGREEMENT
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<DESCRIPTION>EX-10.1 LETTER AGREEMENT
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<DIV align="right" style="font-size: 10pt; margin-top: 12pt"><B>Exhibit&nbsp;10.1</B>
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<DIV align="center" style="font-size: 10pt; margin-top: 18pt">November&nbsp;13, 2007
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Diane M. Barrett<BR>
c/o Noven Pharmaceuticals, Inc.<BR>
11960 SW 144<SUP style="font-size: 85%; vertical-align: text-top">th</SUP>
 Street<BR>
Miami, Florida 33186

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<DIV align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">Dear Diane:</DIV>


<DIV align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">This letter confirms the arrangement regarding your retirement as Vice President and Chief
Financial Officer of Noven Pharmaceuticals, Inc. (&#148;Noven&#148;).</DIV>


<DIV align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Noven has expressed its desire that you continue your employment with Noven until December&nbsp;31,
2007 in order to ensure an orderly transition of your position to your successor.</DIV>


<DIV align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; It is understood and agreed that you will: (a)&nbsp;continue to perform your regular duties as
Noven&#146;s Vice President and Chief Financial Officer until the earlier of December&nbsp;31, 2007 or the
date your successor has been elected to the position of Vice President and Chief Financial Officer;
and (b)&nbsp;you will assist the Corporation in the transition of the position of Vice President and
Chief Financial Officer to your successor from the date hereof through December&nbsp;31, 2007. In the
event that your successor is elected prior to December&nbsp;31, 2007, then you will continue as a Vice
President of Noven, but will no longer serve as Noven&#146;s Vice President and Chief Financial Officer.</DIV>


<DIV align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In exchange for (i)&nbsp;continuing your employment through December&nbsp;31, 2007 (or such later date as
may be mutually agreed to the by the parties) (the &#147;Employment End Date&#148;) in accordance with
paragraph 2 and (ii)&nbsp;signing the Confidential Separation Agreement and General Release of All
Claims attached hereto as Exhibit&nbsp;A, Noven agrees to the following:</DIV>


<DIV align="left" style="margin-left: 2%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">a.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;You will be paid Three Hundred and Ninety-Five Thousand, Eight Hundred and Fifty Dollars
($395,850), which amount will be paid in 26 bi-weekly installments over the 12&nbsp;month period
commencing on the Employment End Date.</DIV>


<DIV align="left" style="margin-left: 2%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">b.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;You will receive an annual bonus for 2007 determined in accordance with Noven&#146;s 2007 Annual
Incentive Plan and paid at the same time and manner as such payment is made to Noven&#146;s other
executive officers.</DIV>


<DIV align="left" style="margin-left: 2%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">c.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;You will be paid all of your accrued but unused vacation time which you had earned through the
Employment End Date. You will not continue to earn vacation or other paid time off after the
Employment End Date.</DIV>


<DIV align="left" style="margin-left: 2%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">d.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Your equity awards (stock options and SSARs) granted under Noven&#146;s 1999 Long-Term Incentive Plan
will continue to vest through the Employment End Date. All vesting will cease as of that date and
you will have 12&nbsp;months from your Employment</DIV>


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<DIV align="left" style="margin-left: 2%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">End Date with which to exercise any and all vested awards under and in accordance with Noven&#146;s
1999 Long Term Incentive Plan, provided, however, that this provision shall not extend the original
seven year term of any of your equity awards.</DIV>


<DIV align="left" style="margin-left: 2%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">e.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Your participation in Noven&#146;s medical and dental insurance programs at employee rates will
continue through the end of the month following the date that is twelve months after the Employment
End Date, at which date your participation in such programs will cease in accordance with the terms
of those programs.</DIV>


<DIV align="left" style="margin-left: 2%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">f.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;You will have the option to elect to continue your health care coverage for an additional 18
months under COBRA, provided you pay the full monthly premium cost of the coverage. Detailed
information on COBRA will be provided to you under separate cover.</DIV>


<DIV align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The parties acknowledge that this agreement is not an employment contract, that you will
continue to be an employee &#147;at will&#148;, and that we retain the right to terminate you for any reason
or no reason at any time; provided that if you are terminated for any reason other than for cause
prior to December&nbsp;31, 2007, then you will be entitled to the benefits listed in paragraph 3 hereof.</DIV>


<DIV align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;You have indicated your willingness to discuss an arrangement by which you will provide
consulting services to Noven after your Employment End Date pursuant to a mutually-acceptable
consulting agreement.</DIV>


<DIV align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt; margin-top: 6pt">If you have any questions please do not hesitate to contact me. Otherwise, please indicate your
acceptance of the terms and conditions set forth herein by signing this letter where indicated
below.</DIV>


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    <TD colspan="3" align="left">NOVEN PHARMACEUTICALS, INC.<BR>
<BR>
Sincerely,<BR>


&nbsp;</TD>
    <TD>&nbsp;</TD>
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    <TD align="left">&nbsp;</TD>
    <TD colspan="3" style="border-bottom: 0px solid #000000" align="left">/s/ Carolyn Donaldson
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD colspan="3" align="left">Vice President, Human Resources&nbsp;</TD>
    <TD>&nbsp;</TD>
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    <TD align="left">&nbsp;</TD>
    <TD colspan="3" align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Agreed to and Accepted by:

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">/s/ Diane M. Barrett<BR>
Dated: November&nbsp;13, 2007

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