SANTARUS INC
EXHIBIT 10.2
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<DIV align="right" style="font-size: 10pt; margin-top: 12pt">Exhibit&nbsp;10.2
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><FONT style="font-variant: SMALL-CAPS">CERTAIN MATERIAL (INDICATED BY AN ASTERISK) HAS BEEN OMITTED FROM THIS DOCUMENT PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
SECURITIES AND EXCHANGE COMMISSION.</FONT>
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<DIV align="Center" style="font-size: 10pt; margin-top: 6pt">PROMOTION AGREEMENT

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<DIV align="Center" style="font-size: 10pt; margin-top: 6pt">by and between

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<DIV align="Center" style="font-size: 10pt; margin-top: 6pt">DEPOMED, INC.

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<DIV align="Center" style="font-size: 10pt; margin-top: 6pt">and

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<DIV align="Center" style="font-size: 10pt; margin-top: 6pt">SANTARUS, INC.

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<DIV align="Center" style="font-size: 10pt; margin-top: 6pt">Dated as of July&nbsp;21, 2008

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<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><FONT style="font-variant: SMALL-CAPS"><B>PROMOTION AGREEMENT</B></FONT>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This PROMOTION AGREEMENT (this &#147;<U>Agreement</U>&#148;) is made as of July&nbsp;21, 2008 (the
&#147;<U>Effective Date</U>&#148;), by and between Depomed, Inc., a California corporation
(&#147;<U>Depomed</U>&#148;), and Santarus, Inc., a Delaware corporation (&#147;<U>Santarus</U>&#148;). Each of
Depomed and Santarus is referred to herein individually as a &#147;<U>party</U>&#148; and collectively as
the &#147;<U>parties</U>.&#148;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;WHEREAS, Depomed desires to engage Santarus to promote and market the Products in the
Territory (each as defined below), and Santarus desires to promote and market the Products, all in
accordance with the terms and conditions contained herein;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NOW, THEREFORE, in consideration of the foregoing and of the mutual covenants herein
contained, the parties hereto intending to be legally bound hereby agree as follows:
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<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE I<BR>
DEFINITIONS</B>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As used in this Agreement, the following terms shall have the following meanings:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.1 &#147;<U>500mg Product</U>&#148; means the once-daily formulation of 500 mg of metformin
HCl that is the subject of NDA No.&nbsp;21-748 filed with FDA on April&nbsp;27, 2004 (as such NDA may be
amended or supplemented subsequent to the filing date).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.2 &#147;<U>1000mg Product</U>&#148; means the once-daily formulation of 1000 mg of metformin
HCl that is the subject of NDA No.&nbsp;21-748 filed with FDA on April&nbsp;27, 2004 (as such NDA may be
amended or supplemented subsequent to the filing date).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.3 &#147;<U>Act</U>&#148; means the United States Federal Food, Drug and Cosmetic Act, 21
U.S.C. 301, et. seq., as it may be amended from time to time, and the regulations promulgated
thereunder, including the Generic Drug Act.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.4 &#147;<U>AcuForm&nbsp;Patent License</U>&#148; has the meaning set forth in Section&nbsp;10.1.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.5 &#147;<U>Adverse Drug Experience</U>&#148; means any &#147;<U>adverse drug experience</U>&#148; as
defined or contemplated by 21 C.F.R. 314.80 or 312.32, associated with a Product.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.6 &#147;<U>Adverse Drug Experience Report</U>&#148; means any oral, written or electronic
report of any Adverse Drug Experience transmitted to any Person.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.7 &#147;<U>Advertising/Marketing/Educational Expenses</U>&#148; means the following Santarus
expenses for directly Promoting the Products and conducting Educational Programs with respect to
the Products in the Territory: (a)&nbsp;all out-of-pocket costs for Samples incurred as contemplated by
Section&nbsp;6.5 as well as all out-of-pocket costs for Sample warehousing and distribution, (b)&nbsp;all
out-of-pocket costs for Promotional Materials and training materials, (c)&nbsp;all
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">out-of-pocket costs for sales training meetings to the extent attributable to the Products,
(d)&nbsp;all out-of-pocket costs for the purchase of Prescriber Data (including any prescriber data for
competitive products), (e)&nbsp;all out-of-pocket costs associated with market research, advisory
boards, speaker programs, trade shows and &#147;lunch and learns&#148; and other outreach programs with
respect to the Products, (f)&nbsp;all costs related to scientific liaisons, and national and regional
account managers to the extent attributable to the Products, (g)&nbsp;all costs related to up to one (1)
full-time equivalent dedicated product manager; (h)&nbsp;all Medical Affairs Expenses reimbursed by
Santarus pursuant to Section&nbsp;4.7; and (i)&nbsp;all other out-of-pocket costs and expenses of Santarus
for directly Promoting the Products and conducting Educational Programs with respect to the
Products in the Territory. In the case of Product voucher, coupon, loyalty card or other co-pay
assistance programs approved by the JCC, all out-of-pocket costs of Santarus associated with such
programs (other than redemption costs) shall be treated as Advertising/Marketing/ Educational
Expenses. Notwithstanding the foregoing, (A)&nbsp;the costs set forth in items (f)&nbsp;and (g)&nbsp;above shall
be subject to a $&#091;***&#093; cap per Agreement Quarter and (B)&nbsp;the costs set forth in item (c)&nbsp;above
shall be subject to a $&#091;***&#093; cap during the Launch Period and to a $&#091;***&#093; cap during each twelve
(12)&nbsp;month period thereafter; and such costs in excess of the caps set forth in clauses (A)&nbsp;and (B)
shall not be treated as Advertising/Marketing/Educational Expenses.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.8 &#147;<U>Affiliate</U>&#148; means, with respect to any Person, any other Person that
directly or indirectly controls, is controlled by or is under common control with, such first
Person. For the purposes of this definition, &#147;<U>control</U>&#148; (including, with correlative
meanings, the terms &#147;<U>controlling,</U>&#148; &#147;<U>controlled by</U>&#148; and &#147;<U>under common control
with</U>&#148;), as applied to any Person, means the possession, directly or indirectly, of the power to
direct or cause the direction of the management and policies of that Person, whether through the
ownership of voting securities, by contract or otherwise.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.9 &#147;<U>Agreement</U>&#148; has the meaning set forth in the preamble to this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.10 &#147;<U>Agreement Month</U>&#148; means each calendar month during the Term (including
any partial calendar month in the case of the first and last calendar months of the Term).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.11 &#147;<U>Agreement Quarter</U>&#148; means the Initial Agreement Quarter, each successive
period of three months during the Term after the Initial Agreement Quarter and the Final Agreement
Quarter.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.12 &#147;<U>Annual Plan</U>&#148; has the meaning set forth in Section&nbsp;4.5(a).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.13 &#147;<U>Baseline Percentage</U>&#148; means the percentage determined by dividing (a)&nbsp;the
total number of Units of Product prescribed by Professionals on the Depomed Physician List during
the two (2)&nbsp;complete Agreement Quarters prior to delivery by Depomed of its intention to commence
Promotion and Detailing of the Product in the Territory pursuant to Section&nbsp;4.9, by (b)&nbsp;the total
number of Units of Product prescribed by all Professionals during such two (2)&nbsp;complete Agreement
Quarters, based on Prescriber Data for such two (2)&nbsp;complete Agreement Quarters, as such percentage
may be amended pursuant to Section&nbsp;4.9.
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    <TD nowrap align="left">***</TD>
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    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.14 &#147;<U>BLS</U>&#148; means Biovail Laboratories International SRL, or any Person which
succeeds to the obligations of Biovail Laboratories International SRL under the BLS Agreements.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.15 &#147;<U>BLS Agreements</U>&#148; means, collectively, the BLS License Agreement, the BLS
Manufacturing Transfer Agreement and the BLS Supply Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.16 &#147;<U>BLS Fees</U>&#148; means, for any period, the sum of the following amounts
actually paid by Depomed to BLS in such period: (a)&nbsp;earned royalty payments made pursuant to
Section&nbsp;4.6 of the BLS Manufacturing Transfer Agreement attributable to Promotion Net Sales of the
500mg Product, and (b) (i)&nbsp;the Supply Price (as defined under the BLS Supply Agreement) for the
1000mg Product or (ii)&nbsp;in the event that BLS is no longer supplying the 1000mg Product under the
BLS Supply Agreement, earned royalty payments made pursuant to Section&nbsp;4.2 of the BLS Manufacturing
Transfer Agreement attributable to Promotion Net Sales of the 1000mg Product; but only to the
extent and for so long as such amounts are actually paid by Depomed in respect of supply or the
Promotion Net Sales for such period under the applicable BLS Agreement. In the event the amounts
actually paid under any such BLS Agreement are reduced or terminate, or Depomed receives a credit
for any prior payment of BLS Fees or receives any other payment from BLS under any BLS Agreement,
the BLS Fees will correspondingly be reduced or terminate or the credit or other payment shall be
applied to the then-current calculation of BLS Fees.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.17 &#147;<U>BLS License Agreement</U>&#148; means that certain Amended and Restated License
Agreement (Extended Release Metformin Formulations &#151; Canada), dated as of December&nbsp;13, 2005, by
and between Depomed and BLS, as the same may be amended from time to time.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.18 &#147;<U>BLS Manufacturing Transfer Agreement</U>&#148; means that certain Manufacturing
Transfer Agreement (Controlled Release Metformin Formulations &#151; USA), dated as of December&nbsp;13,
2005, by and between Depomed and BLS, as the same may be amended from time to time.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.19 &#147;<U>BLS Supply Agreement</U>&#148; means that certain Supply Agreement (Extended
Release Metformin Formulations &#151; U.S.A.), dated as of December&nbsp;13, 2005, between Depomed and BLS,
as amended on June&nbsp;30, 2007, as the same may be amended from time to time.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.20 &#147;<U>Branded Extended Release Metformin Products</U>&#148; shall mean (i)&nbsp;Glucophage
XR (metformin hydrochloride) Extended Release Tablets (NDA No.&nbsp;21202) and Fortamet (metformin
hydrochloride) Extended Release Tablets (NDA No.&nbsp;21574), each in the dosage strengths and
formulations marketed as of the Effective Date (and excluding any generic forms of such products);
and (ii)&nbsp;the Products.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.21 &#147;<U>Branded Metformin Products</U>&#148; shall mean (i)&nbsp;Glucophage (metformin
hydrochloride) Tablets (NDA No.&nbsp;20357) in the dosage strengths and formulations marketed as of the
Effective Date (and excluding any generic forms of such product); and (ii)&nbsp;the Branded Extended
Release Metformin Products.
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.22 &#147;<U>cGMP</U>&#148; shall mean current &#147;Good Manufacturing Practices&#148; as such term is
defined from time to time by the FDA or other relevant Governmental Authority having jurisdiction
over the manufacture or sale of a Product pursuant to its regulations, guidelines or otherwise.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.23 &#147;<U>Co-Chairs</U>&#148; has the meaning set forth in Section&nbsp;3.2.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.24 &#147;<U>COGS</U>&#148; means, for a particular period, Depomed&#146;s cost of goods sold
(calculated in accordance with Section&nbsp;7.3(c)) for the Products in the Territory for such period,
but not including (i)&nbsp;BLS Fees, (ii)&nbsp;expenses which are to be deducted from gross sales in reaching
the calculation of Net Sales hereunder, and (iii)&nbsp;costs of Samples purchased from Depomed by
Santarus hereunder.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.25 &#147;<U>Combination Product</U>&#148; has the meaning set forth in Section&nbsp;13.1.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.26 &#147;<U>Confidentiality Agreement</U>&#148; means that certain Confidentiality Agreement,
dated as of May&nbsp;20, 2004, between Depomed and Santarus.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.27 &#147;<U>Control</U>&#148; or &#147;<U>Controlled</U>&#148; means, with respect to patents,
know-how or other intellectual property rights of any kind, the possession by a party of the
ability to grant a license or sublicense of such rights without the payment of additional
consideration and without violating the terms of any agreement or arrangement between such party
and any Third Party.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.28 &#147;<U>DDMAC</U>&#148; means the FDA&#146;s Division of Drug Marketing, Advertising and
Communications, or any successor Governmental Authority performing comparable functions in the
Territory.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.29 &#147;<U>Depomed</U>&#148; has the meaning set forth in the preamble to this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.30 &#147;<U>Depomed Gross Margin</U>&#148; means, for a particular period, (A)&nbsp;Depomed Net
Sales for such period minus (B) (i)&nbsp;all BLS Fees for such period (multiplied by the Depomed
Percentage for such period) and (ii)&nbsp;COGS for such period (multiplied by the Depomed Percentage for
such period).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.31 &#147;<U>Depomed Net Sales</U>&#148; means, for a particular period, Net Sales for such
Period, multiplied by the Depomed Percentage for such period.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.32 &#147;<U>Depomed Percentage</U>&#148; means, for a particular period during which Depomed
is Promoting and Detailing a Product pursuant to Section&nbsp;4.9, the difference of (a)&nbsp;the percentage
determined by dividing (i)&nbsp;the total number of Units of Product prescribed during such period by
Professionals on the Depomed Physician List, by (ii)&nbsp;the total number of Units of Product
prescribed during such period by all Professionals, in each case based on Prescriber Data
for the applicable period; minus (b)&nbsp;the Baseline Percentage; provided that the Depomed
Percentage shall not be less than zero.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.33 &#147;<U>Depomed Physician List</U>&#148; means the list of obstetrics and gynecology
Professionals to whom the Depomed Sales Force may present Details, as such list may be
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">amended from
time to time as contemplated by this Agreement; <U>provided</U> that the list must conform to the
requirements of Section&nbsp;4.9.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.34 &#147;<U>Depomed Promotional Materials</U>&#148; has the meaning set forth in Section
4.9(d).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.35 &#147;<U>Depomed Sales Force</U>&#148; means the field force of Sales Representatives
employed or contracted by Depomed.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.36 &#147;<U>Depomed Supply Failure</U>&#148; means any circumstances under which any back-up
manufacturing rights in favor of Depomed pursuant to any supply arrangement relating to the
applicable formulation of the Product are applicable as a result of a failure to fill wholesaler
and distributor orders of the applicable Product.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.37 &#147;<U>Depomed Trademarks</U>&#148; means (a)&nbsp;Glumetza<SUP style="font-size: 85%; vertical-align: text-top">&#174;</SUP> , (b)&nbsp;the AcuForm&#153; trademark,
for which Depomed has sought registration for in the United States Patent and Trademark Office, and
(c)&nbsp;Depomed<SUP style="font-size: 85%; vertical-align: text-top">&#174;</SUP>, and, in each case, all related domain names and other trademark related rights. The
Depomed Trademarks are attached hereto as <U>Schedule&nbsp;1.37</U>.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.38 &#147;<U>Detail</U>&#148; means an in-person, face-to-face sales presentation of a Product
made by a Sales Representative to a Professional, including a P1 Detail or P2 Detail.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.39 &#147;<U>Educational Programs</U>&#148; means any activities undertaken with respect to
the education of Professionals, pharmacists, managed care representatives or customers regarding a
Product or any indication for a Product or funded by unrestricted educational grants, including
educational programs and seminars and education materials.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.40 &#147;<U>Effective Date</U>&#148; has the meaning set forth in the preamble to this
Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.41 &#147;<U>Evaluation Period</U>&#148; has the meaning set forth in Section&nbsp;13.1.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.42 &#147;<U>Executive Officers</U>&#148; means the Chief Executive Officers of Santarus and
Depomed (or, if there is no such officer, its President or other executive officer designated by
the Chief Executive Officer).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.43 &#147;<U>FDA</U>&#148; means the United States Food and Drug Administration or any
successor agency performing comparable functions in the Territory.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.44 &#147;<U>Final Agreement Quarter</U>&#148; means the period commencing on the first day
following the last full Agreement Quarter during the Term and ending on the last day of the Term.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.45 &#147;<U>Force Majeure Event</U>&#148; has the meaning set forth in Section&nbsp;16.7.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.46 &#147;<U>GAAP</U>&#148; has the meaning set forth in Section&nbsp;7.3(c).
</DIV>


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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.47 &#147;<U>Generic Drug Act</U>&#148; has the meaning set forth in Section&nbsp;9.1(j).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.48 &#147;&#091;***&#093;&#148; means &#091;***&#093;.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.49 &#147;<U>Governmental Authority</U>&#148; shall mean any court, agency, authority,
department, regulatory body or other instrumentality of any government or country or of any
national, federal, state, provincial, regional, county, city or other political subdivision of any
such government or any supranational organization of which any such country is a member, which has
competent and binding authority to decide, mandate, regulate, enforce, or otherwise control the
activities of the parties contemplated by this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.50 &#147;<U>Gross Margin</U>&#148; means, for a particular period, (A)&nbsp;Promotion Net Sales
for such period minus (B) (i)&nbsp;all BLS Fees for such period (multiplied by the Promotion Percentage
for such period), and (ii)&nbsp;COGS for such period (multiplied by the Promotion Percentage for such
period).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.51 &#147;<U>Initial Agreement Quarter</U>&#148; means the period commencing on the Effective
Date and ending on December&nbsp;31, 2008.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.52 &#147;<U>JAMS</U>&#148; has the meaning set forth in Section&nbsp;3.5(b).
</div>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.53 &#147;<U>JCC</U>&#148; has the meaning set forth in Section&nbsp;3.1.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.54 &#147;<U>Launch Period</U>&#148; means the period beginning on the Effective Date and
ending on March&nbsp;31, 2009.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.55 &#147;<U>Launch Plan</U>&#148; means the plan and schedule for the commercial re-launch of
the Products in the Territory during the Launch Period, including the parties&#146; responsibilities for
the activities associated with such commercial re-launch of the Products, a budget for the
activities to be undertaken in connection with such commercial re-launch. The initial Launch Plan
describing a summary of the plan and schedule for commercial re-launch is attached hereto as
<U>Schedule&nbsp;1.55</U>.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.56 &#147;<U>Legal Requirements</U>&#148; means laws, rules and regulations of any
Governmental Authority in the Territory, including, for clarity, all guidelines, policies and
procedures referenced in Section&nbsp;5.3 of this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.57 &#147;<U>Mediation Notice</U>&#148; has the meaning set forth in Section&nbsp;3.5(b).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.58 &#147;<U>Medical Affairs Expenses</U>&#148; means all of Depomed&#146;s out-of-pocket costs
related to the handling of medical inquiries under Section&nbsp;4.7 to the extent attributable to the
Product.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.59 &#147;<U>Metformin Product Rights</U>&#148; has the meaning set forth in Section&nbsp;13.1.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.60 &#147;<U>Minimum Detailing Obligations</U>&#148; has the meaning set forth in Section
4.1(b).
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
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    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.61 &#147;<U>Minimum Detailing Period</U>&#148; has the meaning set forth in Section&nbsp;4.1(b).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.62 &#147;<U>NDA</U>&#148; means any &#147;<U>new drug application</U>&#148; (as such term is used
under the Act) filed or acquired by Depomed or any Affiliate with the FDA with respect to a Product
and all subsequent submissions, supplements and amendments thereto, including NDA No.&nbsp;21-748 filed
with the FDA on April&nbsp;27, 2004 (as such NDA may be amended or supplemented subsequent to the filing
date).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.63 &#147;<U>Negotiation Period</U>&#148; has the meaning set forth in Section&nbsp;13.1.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.64 &#147;<U>Net Sales</U>&#148; means, for a particular period, the gross amount invoiced on
sales of Product in the Territory recognized as gross revenue in accordance with GAAP by Depomed,
its Affiliates, licensees, sublicensees and assigns to independent, unrelated Third Parties during
such period in bona fide arms&#146; length transactions, less the following deductions, calculated to
arrive at net sales in accordance with GAAP: (a)&nbsp;freight, insurance (but only insurance with
respect to shipping the Product), and other transportation charges to the extent added to the sales
price and set forth separately as such on the total amount invoiced; (b)&nbsp;any sales, use,
value-added, excise taxes or duties or allowances on the selling price of Product to the extent
added to the sales price and set forth separately as such on the total amount invoiced; (c)
chargebacks, trade, quantity and cash discounts and rebates to the extent customary in the trade,
including governmental rebates; (d)&nbsp;allowances or credits, including allowances or credits to
customers on account of rejection, defects or returns of the Product, or because of a retroactive
price reduction; and (e)&nbsp;redemption costs associated with any Product voucher, coupon, loyalty card
or other co-pay assistance programs approved by the JCC, or listed in <U>Schedule&nbsp;4.5(h)</U>. Net
Sales shall not include a sale or transfer to an Affiliate, licensee, sublicensee or assign of
Santarus or Depomed or if done for clinical, regulatory or governmental purposes where no
consideration is received; but the resale by such Affiliate, licensee, sublicensee or assign of
Santarus or Depomed shall be considered a sale of such Product. For purposes of clarity, it is the
intent of the parties that &#147;Net Sales&#148; for the purposes of this Agreement shall be consistent with
the GAAP net sales reported by Depomed in its periodic reports with the U.S. Securities and
Exchange Commission.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.65 &#147;<U>Order</U>&#148; means any award, decision, injunction, judgment, decree, order,
ruling, or verdict entered, issued, made, or rendered by any Governmental Authority or by any
arbitrator.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.66 &#147;<U>P1 Detail</U>&#148; means a Detail in which the promotional message involving a
Product is presented in the first position and is the principal topic of discussion during the
contact.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.67 &#147;<U>P2 Detail</U>&#148; means a Detail in which the promotional message involving a
Product is presented in the second position and is emphasized more than any other product in the
Detail, except for the product in the P1 Detail.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.68 &#147;<U>PDMA</U>&#148; means the Prescription Drug Marketing Act, as amended, and the
rules and regulations promulgated thereunder.
</DIV>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.69 &#147;<U>Patheon</U>&#148; means Patheon Puerto Rico, Inc. (f/k/a MOVA Pharmaceutical
Corporation), or any Person which succeeds to the obligations of Patheon Puerto Rico, Inc. under
the Patheon Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.70 &#147;<U>Patheon Agreement</U>&#148; means that certain Commercial Manufacturing
Agreement, dated as of December&nbsp;19, 2006, by and between Depomed and Patheon, as the same may be
amended from time to time.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.71 &#147;<U>Person</U>&#148; means any individual, corporation (including any non-profit
corporation), general or limited partnership, limited liability company, joint venture, estate,
trust, association, organization, labor union, or other entity or Governmental Authority.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.72 &#147;<U>Prescriber Data</U>&#148; means data provided by a Third Party which measures
prescriptions filled for Products (by individual prescriber) in the Territory during a specified
time period, from a source mutually agreed in writing by the parties (it being understood that each
of IMS Health Incorporated and Wolters Kluwer is a source agreeable to the parties).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.73 &#147;<U>Product(s)</U>&#148; means any pharmaceutical product formulation for human use
containing metformin or any other salt, chiral forms or metabolites thereof as the sole active
pharmaceutical ingredient, including the 500mg Product and the 1000mg Product.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.74 &#147;<U>Product Complaints</U>&#148; means any report concerning the quality, purity,
quantity, weight, pharmacologic activity, labeling, identity or appearance of a Product.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.75 &#147;<U>Professional</U>&#148; means a physician or other health care practitioner who is
permitted by law to prescribe Products.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.76 &#147;<U>Promote,</U>&#148; &#147;<U>Promotional</U>&#148; and &#147;<U>Promotion</U>&#148; mean, with
respect to a Product, any activities undertaken to encourage sales or use of such Product,
including Details, product sampling, detail aids, drop-offs, coupons, discount cards, journal
advertising, direct mail programs, direct-to-consumer advertising, convention exhibits and all
other forms of marketing, advertising, public relations or promotion.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.77 &#147;<U>Promotion Commencement Date</U>&#148; has the meaning set forth in Section
4.1(e).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.78 &#147;<U>Promotion Fees</U>&#148; has the meaning set forth in Section&nbsp;7.2(a).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.79 &#147;<U>Promotion Net Sales</U>&#148; means Net Sales multiplied by the Promotion
Percentage.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.80 &#147;<U>Promotion Percentage</U>&#148; means, for a particular period, 100% minus the
Depomed Percentage for such period, if any Depomed Net Sales occur in such period.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.81 &#147;<U>Promotional Effort</U>&#148; has the meaning set forth in Section&nbsp;4.1(a).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.82 &#147;<U>Promotional Materials</U>&#148; has the meaning set forth in Section&nbsp;4.4(a).
</DIV>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.83 &#147;<U>Proprietary Information</U>&#148; means any proprietary or confidential
information communicated from one party to the other in connection or relating to this Agreement,
which is identified as confidential or proprietary, or which the other party knows or has reason to
know is confidential or proprietary, including the Technology and financial, marketing, business,
technical and scientific information or data, information related to Santarus&#146; compensation of its
Sales Representatives, information contained within the Annual Plan and Launch Plan, and the
information described in Section&nbsp;4.6, whether communicated in writing, orally or electronically.
Proprietary Information shall not include information that the receiving party can show through
written documentation:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;at the time of disclosure, is publicly known;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;after the time of disclosure, becomes part of the public domain, except by breach of an
agreement between the disclosing party or any Affiliate thereof and the receiving party or any
Affiliate thereof;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;is or was in the possession of the receiving party or any Affiliate thereof at the time of
disclosure by the disclosing party and was not acquired directly or indirectly from the disclosing
party or any Affiliate thereof or from any other party under an agreement of confidentiality to the
disclosing party or any Affiliate thereof; and
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;is or was developed by the receiving party or its Affiliates without use of or reference
to the other party&#146;s Proprietary Information.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.84 &#147;<U>Regulatory Approval</U>&#148; means any and all consents or other authorizations
or approvals required from a Governmental Authority to market and sell a Product in the Territory,
but excluding any form of reimbursement approval.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.85 &#147;<U>Safety Stock</U>&#148; has the meaning set forth in Section&nbsp;6.1.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.86 &#147;<U>Sales Force Expenditures</U>&#148; means the costs allocated to the Santarus
Sales Force in accordance with Section&nbsp;4.1(c).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.87 &#147;<U>Sales Representatives</U>&#148; means sales representatives employed by Santarus
or Depomed, or a Third Party engaged by Santarus or Depomed, to Detail the Products, who have been
trained and equipped to Detail the Products in accordance with this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.88 &#147;<U>Samples</U>&#148; has the meaning set forth in Section&nbsp;6.5.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.89 &#147;<U>Santarus</U>&#148; has the meaning set forth in the Preamble to this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.90 &#147;<U>Santarus CAC</U>&#148; means Santarus&#146; Copy Approval Committee.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.91 &#147;<U>Santarus Manufacturing Notice</U>&#148; has the meaning set forth in Section&nbsp;6.6.
</DIV>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.92 &#147;<U>Santarus Sales Force</U>&#148; means the field force of Sales Representatives
employed or engaged by Santarus, including field-based sales force management such as regional and
district sales managers.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.93 &#147;<U>Santarus Trademarks</U>&#148; means the trademarks set forth on <U>Schedule
1.93</U>, including the &#147;<U>Santarus</U>&#148; trademark and associated design and logo.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.94 &#147;<U>Serious Adverse Drug Experience</U>&#148; means any Adverse Drug Experience,
including those subject to expedited reporting as defined in the regulations cited below, that is
fatal or life-threatening, requires hospitalization or prolongation of existing hospitalization,
results in persistent or significant disability or incapacity, is a congenital anomaly/birth
defect, or is of comparable medical significance or any other event which would constitute a
&#147;<U>serious</U>&#148; Adverse Drug Experience pursuant to the terms of 21 C.F.R. 314.80 or 312.32.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.95 &#147;<U>Serious Adverse Drug Experience Report</U>&#148; means any Adverse Drug
Experience Report that involves a Serious Adverse Drug Experience.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.96 &#147;<U>Subcontracting</U>&#148; means subcontracting or sublicensing a party&#146;s rights or
obligations hereunder (a)&nbsp;pursuant to which a Third Party will manufacture the Products; or (b)
pursuant to which a Third Party Sales Representative is engaged to Promote the Products.
&#147;<U>Subcontractor</U>&#148; means the Third Party with whom the Subcontracting agreement is entered
into.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.97 &#147;<U>Technology</U>&#148; means all pharmacological, toxicological, preclinical,
clinical, technical or other information, data and analysis and know-how relating to the
registration, manufacture, packaging, use, marketing or sale of a Product and all proprietary
rights relating thereto owned by Depomed or its Affiliates or to which Depomed or its Affiliates
has rights so as to be able to license.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.98 &#147;<U>Term</U>&#148; has the meaning set forth in Section&nbsp;8.1.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.99 &#147;<U>Territory</U>&#148; means the United States, including its territories and
possessions and Puerto Rico.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.100 &#147;<U>Third Party</U>&#148; means any Person other than Santarus or Depomed or their
respective Affiliates.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.101 &#147;<U>Unit</U>&#148; means one (1)&nbsp;tablet of the 1000mg Product and two (2)&nbsp;tablets of
the 500mg Product; provided that &#147;Unit&#148; shall have such other meaning as the parties may negotiate
in good faith in the event that either party reasonably determines that the then current definition
of Unit does not equitably reflect differences in value between the 500mg Product and the 1000mg
Product for purposes of calculating the Baseline Percentage and the Depomed Percentage. <U> </U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.102 &#147;<U>United States Bankruptcy Code</U>&#148; means the U.S. Bankruptcy Code, 11
U.S.C. &#167;&#167; 101, et seq.
</DIV>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.103 &#147;<U>Valid Claim</U>&#148; means a claim in any issued patent or pending patent
application which (a)&nbsp;has not been held invalid or unenforceable by a non-appealed or un-appealable
decision of a court or government agency or other appropriate body of competent jurisdiction and
has not been admitted invalid through disclaimer or dedication to the public, and (b)&nbsp;has not
expired, been determined to be unenforceable, been cancelled, withdrawn, abandoned or been on file
with the applicable patent office for more than seven (7)&nbsp;years from the earlier of its date of
filing or earliest claim of priority under 35 U.S.C. &#167;119 or &#167;120 and its successors in the United
States.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;1.104 &#147;<U>Volume Forecast</U>&#148; has the meaning set forth in Section&nbsp;6.3.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE II<BR>
GRANT</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;2.1 <U><B>Grant of Promotion Rights</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;During the Term, subject to the terms and conditions of this Agreement (including Depomed&#146;s
right to elect to Promote the Products as set forth in Section&nbsp;4.9), Depomed hereby grants to
Santarus and its Affiliates and Santarus and its Affiliates hereby accept an exclusive right to
Promote the Products under the Depomed Trademarks in the Territory, on the terms and subject to the
conditions set forth herein. Depomed agrees that its and its Affiliates&#146; right to Promote the
Products is limited to the rights set forth in Section&nbsp;4.9.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;2.2 <U><B>Sublicense</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Except pursuant to Section&nbsp;16.9 or in connection with the use of Third Party Sales
Representatives, Santarus shall not assign, subcontract or otherwise transfer or delegate any of
its rights or obligations under this Agreement without the express written consent of Depomed,
which consent may be withheld by Depomed in its sole discretion.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;2.3 <U><B>Limitation on Metformin Promotion</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Except as expressly contemplated by this Agreement (including Article&nbsp;XIII hereof) and subject
to Section&nbsp;13.1 hereof, Santarus shall not promote, market or distribute any product containing
metformin hydrochloride as the sole active ingredient in the Territory during the Term of this
Agreement, other than the Products.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;2.4 <U><B>Retention of Rights</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Depomed retains and shall retain all proprietary and property interests in the Products until
the point of sale or, in the case of Samples, until delivered to Santarus as contemplated by
Section&nbsp;6.5. Santarus will not have nor represent that it has any control or proprietary or
property interests in the Products, except for the licenses and rights specifically granted
hereunder. Except as expressly set forth herein, nothing contained herein shall be deemed to grant
Santarus, by implication, a license or other right or interest in any patent, trademark or other
similar property of Depomed or its Affiliates, except as may be necessary for Santarus to Promote
the Products pursuant to this Agreement or to manufacture the Products in accordance with Section
6.6. Except
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">as expressly set forth herein, nothing contained herein shall be deemed to grant
Depomed, by implication, a license or other right or interest in any patent, trademark or other
similar property of Santarus or its Affiliates, except as may be necessary for Depomed to Promote
the Products pursuant to this Agreement.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE III<BR>
JOINT COMMERCIALIZATION COMMITTEE</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;3.1 <U><B>Establishment</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The parties agree to establish, for the purposes specified herein, a Joint Commercialization
Committee (the &#147;<U>JCC</U>&#148;). The parties acknowledge and agree that the JCC does not have the
power to amend, modify or waive any of the terms or conditions of this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;3.2 <U><B>Joint Commercialization Committee</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The JCC shall be established by the parties and shall be comprised of four (4)&nbsp;members, two
(2)&nbsp;of whom shall be appointed by Depomed and two (2)&nbsp;of whom shall be appointed by Santarus. Each
party has indicated to the other its initial appointments to the JCC. A party may change any of
its representatives at any time if a new person is appointed to any of the foregoing positions by
giving written notice to the other party. The total number of JCC members may be changed by
unanimous vote of the JCC from time to time as appropriate; provided, that the JCC shall in all
cases be comprised of an equal number of members from each of Depomed and Santarus. Santarus and
Depomed each will designate one representative of such party to serve as co-chairs of the JCC (the
&#147;<U>Co-Chairs</U>&#148;). The members appointed to the JCC by each party shall be employees of such
party and shall be vested with appropriate decision-making authority and power by such party. The
Chief Executive Officers of Santarus and Depomed shall not be members of the JCC.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;3.3 <U><B>JCC Responsibilities</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Except as otherwise set forth herein, the JCC shall provide strategic oversight of all
Promotional activities for the Products hereunder, it being understood that Santarus shall be
responsible for directing such Promotional and marketing activities. The responsibilities of the
JCC shall be exercised consistent with this Agreement and shall include, but shall not be limited
to:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;reviewing the Annual Plan as contemplated by Section&nbsp;4.5(a);
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;reviewing material modifications by Santarus to the Annual Plan or the Launch Plan;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;reviewing Santarus&#146; Product Promotion strategies and objectives, including Product
positioning, messaging and branding;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) if applicable, monitoring the Depomed Sales Force call plan for coordination with the
Santarus Sales Force;
</DIV>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;monitoring advertising placement and market responses, including any post-implementation
reviews;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;reviewing and approving any Volume Forecasts and reviewing any Sample forecasts,
consistent with Section&nbsp;6.3;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g)&nbsp;establishing pricing for commercial sale of Products by or on behalf of Depomed, including
the timing of any pricing changes;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h)&nbsp;reviewing sales incentive compensation plans for the Santarus Sales Force related to the
Products;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;establishing contracting guidelines for the distribution of the Products (or if no such
guidelines have been established, approving any new or amended contracts);
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j)&nbsp;establishing contracting guidelines for the managed care and government markets (or if no
such guidelines have been established, approving any new or amended contracts);
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k)&nbsp;proposing any new packaging design for the Products (subject to Depomed&#146;s approval, and
followed by and subject to applicable FDA and other Legal Requirements);
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l)&nbsp;establishing the Net Sales forecast for 2009 for purposes of calculating the minimum
Advertising/Marketing/Educational Expenses for that year in accordance with Section&nbsp;4.1(d);
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m)&nbsp;reviewing and approving any Product voucher, coupon, loyalty card or other co-pay
assistance programs;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(n)&nbsp;reviewing and approving any proposed material capital expenditures relating to the
manufacture of the Products; and
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(o)&nbsp;such other functions as may be mutually agreed upon by the parties from time to time.
</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">For the avoidance of doubt, (i)&nbsp;the JCC shall not have any review or approval rights with respect
to any matters relating to the development of the Products, (ii)&nbsp;any decisions of the JCC with
respect to matters which relate to Regulatory Approval for a Product shall require Depomed&#146;s prior
written consent, (iii)&nbsp;the JCC cannot require Santarus to pay more than the minimum amounts
described in Section&nbsp;4.1 with respect to Advertising/Marketing/Educational Expenses or Sales Force
Expenditures, and (iv) &#147;reviewing&#148; as set forth above shall not imply any approval right or other
decision-making power on the part of the JCC.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;3.4 <U><B>Meetings of the JCC.</B></U>
</DIV>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Meetings of the JCC may be called by the Co-Chairs of the JCC from time to time and, upon no
less than ten (10)&nbsp;days&#146; notice, shall otherwise be called when requested by a party; provided,
however, that meetings of the JCC shall be held monthly during the first six months of the Term,
and on at least a quarterly basis thereafter. If possible, the meetings shall be held in person or
where appropriate, by video or telephone conference. Unless otherwise agreed, the location of any
in-person meetings of the JCC shall alternate between the corporate offices of the parties. The
parties shall determine the form of the meetings. Subject to Section&nbsp;3.5, decisions shall be made
unanimously, each party having one (1)&nbsp;vote regardless of the number of representatives present or
voting; provided, that no such vote shall be valid unless each party is represented by at least two
(2)&nbsp;members either by written proxy or actual presence at the meeting at which the vote is taken.
Subject to appropriate confidentiality undertakings where applicable, each party shall have the
right, upon written notice to the other party, to have present at JCC meetings additional,
non-voting participants (not to exceed ten such participants at any JCC meeting without the consent
of the other party). Such additional participants shall not be deemed to be, or have any rights or
responsibilities of, a member of the JCC. The parties shall cause their respective representatives
on the JCC to use their reasonable efforts to resolve all matters presented to them as
expeditiously as possible. The party hosting any meeting shall propose the agenda for the meeting
and appoint a secretary to the meeting who shall record the minutes of the meeting. Such minutes
shall be circulated to the parties promptly following the meeting for review and comment and for
unanimous ratification by both parties. Each party shall bear its own travel and related costs
incurred in connection with participation in the JCC.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;3.5 <U><B>JCC Disputes</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;In the event that the JCC is, after a period of ten (10)&nbsp;days, unable to make a decision
due to a lack of required unanimity, either party may submit the matter being considered to the
Executive Officers for a joint decision. In such event, either Co-Chair of the JCC, by written
notice to the other party, shall formally request the dispute be resolved by the Executive
Officers, specifying the nature of the dispute with sufficient detail to permit adequate
consideration by the Executive Officers. The Executive Officers shall diligently and in good faith
attempt to resolve the referred dispute expeditiously and, in any event, within fifteen (15)&nbsp;days
of receiving such written notification.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;In the event that the Executive Officers are unable to reach a resolution of any referred
dispute after good faith negotiations during the fifteen (15)-day period referred to in Section
3.5(a) above and in the event such dispute is not related to compliance with this Agreement,
regulatory matters, or the validity, breach or interpretation of this Agreement, either
party may commence mediation within fifteen (15)&nbsp;days after the conclusion of such fifteen
(15)-day period by providing to the other party a written request for non-binding mediation,
setting forth the subject of the dispute and the relief requested (a &#147;<U>Mediation Notice</U>&#148;).
The parties will cooperate with Judicial Arbitration and Mediation Services (&#147;<U>JAMS</U>&#148;) and
with one another in selecting a mediator from JAMS&#146; panel of neutrals, and in scheduling the
mediation proceedings. The parties shall endeavor to conclude any mediation under this Section&nbsp;3.5
within thirty (30)&nbsp;days after delivery by either party of Mediation Notice. The parties covenant
that they will participate in the mediation in good faith and that they will share equally in its
costs; provided that each party will be responsible for its own attorneys&#146; fees. Either party may
seek equitable relief prior to the mediation to preserve the status quo pending the completion of
that process. Except
</DIV>

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</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">for such an action to obtain equitable relief, neither party may commence a
civil action with respect to the matters submitted to mediation until after the completion of the
initial mediation session, or thirty (30)&nbsp;days after delivery of the Mediation Notice, whichever
occurs first.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Any disputes referred to the Executive Officers for resolution pursuant to this Section
3.5 shall not be subject to any dispute resolution mechanism or procedure other than pursuant to
this Section&nbsp;3.5.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE IV<BR>
PRODUCT PROMOTION</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;4.1 <U><B>Product Promotion</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Subject to applicable Legal Requirements, as well as the provisions of this Agreement,
Santarus shall, from and after the Promotion Commencement Date, at its sole expense, use
commercially reasonable efforts to Promote the Products within the Territory in accordance with the
Launch Plan or Annual Plan (the &#147;<U>Promotional Effort</U>&#148;). For purposes of the preceding
sentence, Santarus&#146; commercially reasonable efforts shall be met if Santarus is in compliance with
its obligations under Section&nbsp;4.1(b), 4.1(c), 4.1(d) and 4.1(e) of this Agreement. Santarus will
cause the Santarus Sales Force and Santarus employees and agents acting on Santarus&#146; behalf to
comply with this Agreement and all applicable Legal Requirements in connection with the Promotion
of the Products. It is understood, and Santarus agrees, that it will be accountable for the acts
or omissions of the Santarus Sales Force and its employees and agents to the extent such acts or
omissions fail to comply with Santarus&#146; obligations under this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;From the Promotion Commencement Date and through the first anniversary of such Promotion
Commencement Date (the &#147;<U>Minimum Detailing Period</U>&#148;), the Santarus Sales Force shall perform
a minimum of &#091;***&#093; P1 Details and a minimum of &#091;***&#093; P2 Details (the &#147;<U>Minimum Detailing
Obligations</U>&#148;); &#091;***&#093;. For purposes of determining P1 and P2 Details hereunder, each Product
shall be deemed to be the same Product and shall be counted only once. By way of illustration,
Santarus shall not have the right to count both a P1 Detail for the 500mg Product and a P2 Detail
for the 1000mg Product. In such case, only the P1 Detail shall be counted for purposes of
determining compliance with the Minimum Detailing Obligations.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;During each of the &#091;***&#093; periods within the &#091;***&#093; month period following the end of the
Minimum Detailing Period, Santarus Sales Force Expenditures shall equal at least
&#091;***&#093; percent (&#091;***&#093;%) of the immediately prior &#091;***&#093; Promotion Net Sales. From and after the
end of such &#091;***&#093; month period, the minimum shall be reduced to &#091;***&#093; percent (&#091;***&#093;%) of the
immediately prior &#091;***&#093; Promotion Net Sales. Santarus Sales Force Expenditures for any &#091;***&#093;
period shall be calculated as follows: (i)&nbsp;each P1 Detail shall be valued at $&#091;***&#093;; and (ii)&nbsp;each
P2 Detail shall be valued at $&#091;***&#093; ($&#091;***&#093; for any period during which a particular Santarus Sales
Representative who is delivering Details is at the same time delivering details for two (2)&nbsp;or more
additional products), with such amounts to be increased on each May 1 by the amount of increase in
the Consumer Price Index published for the prior year.
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

</TABLE>




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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;From and after the Effective Date and for the remainder of the Term, Santarus shall spend
at least the following amounts on Advertising/Marketing/Educational Expenses during the periods set
forth below:
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="40%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="58%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Period</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Advertising/Marketing/Educational Expenses</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom" style="background: #cceeff">
    <TD><DIV style="margin-left:15px; text-indent:-15px">Effective Date through March&nbsp;31, 2008</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">$5,000,000</TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">&#091;***&#093;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&#091;***&#093;</TD>
</TR>
<TR valign="bottom" style="background: #cceeff">
    <TD><DIV style="margin-left:15px; text-indent:-15px">&#091;***&#093;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&#091;***&#093;</TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">&#091;***&#093;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&#091;***&#093;</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;Santarus shall commence (the date of such commencement, the &#147;<U>Promotion Commencement
Date</U>&#148;) Promotion (including Details by the Santarus Sales Force) of the Products in accordance
with this Agreement and the performance of the other obligations contained herein that are required
to be performed from and after the Promotion Commencement Date as soon as practicable following the
date hereof, but no later than &#091;***&#093;, 2008. The parties agree to cooperate with each other in good
faith in furtherance of the preceding sentence.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;For the avoidance of doubt, the obligations of Santarus as set forth in this Section&nbsp;4.1
shall be suspended for any period of time during which Depomed is unable to: (i)&nbsp;timely supply
Samples or trade Product in accordance with Article&nbsp;6 or (ii)&nbsp;maintain the continued effectiveness
of the Regulatory Approvals.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;4.2 <U><B>Representations to Customers</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Santarus will not make any false or misleading representations to Professionals, customers or
others regarding Depomed or the Products and will not make any representations, warranties or
guarantees with respect to the specifications, features or capabilities of the Products that are
not consistent with the applicable then-current FDA approved labeling and package insert (except to
the extent permitted by Legal Requirements). Santarus agrees to undertake timely and complete
corrective action for any deviations from this Section&nbsp;4.2, subject to discussion and review by
Depomed&#146;s regulatory affairs and quality assurance department.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;4.3 <U><B>Staffing; Training</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Santarus shall be solely responsible for all costs and expenses of compensating its Sales
Representatives. Consistent with applicable Legal Requirements, Santarus shall pay incentive
compensation to its Sales Representatives with respect to the Products in accordance with Santarus&#146;
incentive compensation plan for Santarus&#146; own products; it being understood that, through the
Minimum Detailing Period, such incentive compensation shall constitute (i)&nbsp;at least &#091;***&#093; percent
(&#091;***&#093;%) (on a pro-rated basis) of the total targeted cash
</DIV>

<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>
</TABLE>



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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">incentive compensation under Santarus&#146; field incentive compensation plans for the aggregate of
Santarus Sales Representatives engaged in Detailing Products under this Agreement, and (ii)&nbsp;at
least &#091;***&#093; percent (&#091;***&#093;%) (on a pro-rated basis) of the sales component (and excluding any MBO
component) of the targeted cash incentive compensation under Santarus&#146; field incentive compensation
plans for the aggregate of Santarus district sales managers involved in the Promotion of the
Product. Santarus shall notify its Sales Representatives and district sales managers prior to the
Promotion Commencement Date and consistent with its procedures for Santarus&#146; other products of the
total potential incentive compensation for the Products. For clarity, the minimum incentive
compensation requirement in this Section&nbsp;4.3 does not apply to sales force management (other than
district sales managers), such as regional sales managers.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Depomed shall make available to Santarus any training materials created by Depomed prior
to the Effective Date at Depomed&#146;s out-of-pocket cost for printing and delivering such materials
(and such costs shall be included in the Advertising/Marketing/Education Expenses for Santarus).
In consultation with Depomed, Santarus may modify any such training materials or develop additional
training materials for its Sales Representatives with respect to a Product; provided that such
modified or developed training materials shall be subject to Depomed&#146;s review as Promotional
Materials as provided in Section&nbsp;4.4. Promptly after the Effective Date, at a time and location to
be agreed upon by the parties consistent with the Launch Plan, Depomed shall make available to
Santarus, at Depomed&#146;s cost and expense, personnel and materials for one &#147;train the trainers&#148;
meeting to facilitate Santarus&#146; training of its Sales Representatives. Santarus shall, at its own
expense subsequent to the &#147;train the trainers&#148; meeting and prior to the Promotion Commencement
Date, provide training programs to its Sales Representatives consistent with Santarus&#146; obligations
hereunder and all other Legal Requirements. Such programs shall include training with respect to
reporting Adverse Drug Experiences and technical complaints. After the initial training, Santarus
shall periodically provide additional training to each of its Sales Representatives, and shall
update its training materials as appropriate in connection with such additional training, in
accordance with this Section&nbsp;4.3.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;4.4 <U><B>Promotional Materials; Educational Materials</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Subject to Sections&nbsp;4.4(b), 4.4(c) and 4.9, Santarus shall, at its own expense (which for
clarity shall be included as an Advertising/Marketing/Educational Expense hereunder) have the right
to create, develop, produce or otherwise obtain, and utilize sales, promotional, advertising,
marketing, educational and training materials (&#147;<U>Promotional Materials</U>&#148;) which are necessary
to support fully the Promotional Effort for the Products. Such Promotional Materials may include,
by way of example, detailing aids; leave behind items; premium branded items; journal advertising;
educational programs; formulary binders; appropriate reprints and reprint carriers; product
monographs; patient support kits; convention exhibit materials; direct mail; market research survey
and analysis; training materials; and scripts for telemarketing and teleconferences. All
Promotional Materials used by the Santarus Sales Force or bearing the Santarus Trademarks will be
subject to the review and approval of the Santarus CAC. All Promotional Materials developed by
Santarus hereunder shall prominently display such Depomed Trademark(s) as shall be specified by
Depomed to Santarus following its review of the applicable prototype in accordance with Section
4.4(b).
</DIV>

<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>
</TABLE>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Prior to the use thereof, Santarus shall provide to Depomed a prototype of any Promotional
Materials created by Santarus for review. Depomed shall notify Santarus of any objections it has
to such prototype and the basis therefor as soon as reasonably practicable, but no later than ten
(10)&nbsp;business days following its receipt thereof (five (5)&nbsp;business days during the Launch Period).
Santarus shall modify such Promotional Materials to the extent necessary to resolve any objections
made by Depomed to such Promotional Materials on the grounds that such Promotional Materials are
inconsistent with any Legal Requirements or this Agreement and shall in good faith consider any of
Depomed&#146;s other objections. The final version of the Promotional Materials approved by the
Santarus CAC shall be provided to Depomed for its review and approval to confirm their consistency
with the prototype approved by Depomed and the resolution of Depomed&#146;s objections in accordance
with this Section&nbsp;4.4(b), which review and approval shall occur, as soon as reasonably practicable,
but no later than five (5)&nbsp;business days following its receipt by Depomed. Upon approval, the
Promotional Materials may be produced in quantity, and Santarus shall provide Depomed with the
requisite number of copies of the final printed form in a timely manner so as to allow Depomed to
satisfy its obligation to file such materials with the FDA prior to the first use of the
Promotional Materials, and Depomed will make such filing with the FDA within five (5)&nbsp;business days
of its receipt of such copies. In furtherance of the foregoing provisions of this Section&nbsp;4.4(b),
the parties will endeavor to cooperate to facilitate the timely and efficient review of Promotional
Materials and resolution of any disputes or disagreements related to Promotional Materials, with a
view to containing both parties&#146; internal personnel resources and external costs associated with
the creation, review and approval of the Promotional Materials.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;At Santarus&#146; request, Depomed shall make available to Santarus any Promotional Materials
created by Depomed prior to the Effective Date, including electronic copies of Promotional
Materials, at Depomed&#146;s out-of-pocket cost for printing and delivering such materials (and such
costs shall be included in the Advertising/Marketing/Education Expenses for Santarus). On or prior
to the Promotion Commencement Date, Depomed shall deliver to Santarus all such Promotional
Materials created by Depomed in its inventory. The Promotional Materials supplied to Santarus
under this Section&nbsp;4.4(c) shall be delivered to a single location specified by Santarus in writing
prior to such delivery. Depomed hereby grants to Santarus the exclusive right, during the Term, to
use the Promotional Materials supplied to Santarus pursuant to this Section&nbsp;4.4(c) in the
performance of its obligations under this Agreement.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Depomed shall own all copyrights to all Promotional Materials that are created during the
Term of this Agreement in connection with and to the extent relating to the Promotion of the
Products. Santarus shall use commercially reasonable efforts consistent with accepted business
practices to obtain such assignments from the authors and creators of such materials as may be
necessary to vest ownership of the copyright in Depomed. Depomed shall, and does hereby, grant to
Santarus a royalty-free license to use and reproduce such materials solely in conjunction with its
Promotion of the Products pursuant to this Agreement, which license shall not be assignable or
transferable by Santarus, except in accordance with the terms of Section&nbsp;2.2.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;4.5 <U><B>Annual Plan; Promotion Expenses</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;On or prior to October&nbsp;31st of the preceding calendar year with respect to each calendar
year during the Term beginning with the 2009 calendar year, Santarus shall develop
</DIV>


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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">an annual commercialization plan (the &#147;<U>Annual Plan</U>&#148;) and submit the Annual Plan to the
JCC for review. The Annual Plan shall set forth the manner in which Santarus anticipates it will
Promote the Products during the period to which the Annual Plan relates; provided, however, that
the Annual Plan may be modified from time to time as Santarus reasonably deems appropriate for the
Promotion of the Products, subject where applicable to Santarus&#146; compliance with its obligations
under this Agreement, including without limitation the obligations set forth in Section&nbsp;4.1. Any
such modified Annual Plan shall be provided to the JCC for its review at its next regularly
scheduled meeting. The Annual Plan shall include, at a minimum:
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;the anticipated number of quarterly and annual Details (including P1 Details and P2
Details) to be provided by the Santarus Sales Force, and the physicians targeted to receive those
Details;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;product positioning, strategy and tactics with supporting advertising and promotional
activity to be undertaken;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;planned public relations activities, if any;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv)&nbsp;any training or sampling programs to be conducted;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v)&nbsp;medical education programs to be conducted;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi)&nbsp;pricing and contracting strategies; provided, however, that Product pricing shall be
established as set forth in Section&nbsp;3.3;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii)&nbsp;managed health care strategies and tactics; provided, however, that managed care
contracting guidelines shall be established as set forth in Section&nbsp;3.3; and
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii)&nbsp;a budget for all costs and expenses associated with the activities to be undertaken
pursuant to the Annual Plan (including the projected Advertising/Marketing/Educational Expenses and
Sales Force Expenditures).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;In addition, on or prior to October&nbsp;31st of the preceding calendar year with respect to
each calendar year during the Term beginning with the 2009 calendar year, Depomed shall provide the
following information to the JCC to assist the JCC in its review of the Annual Plan: (i)&nbsp;Product
manufacturing and distribution forecasts for the coming year (including forecasted COGS and BLS
Fees), and (ii)&nbsp;plans for and reasonably detailed reports summarizing any data resulting from
post-marketing clinical studies that Depomed, in its sole discretion and expense, decides to
conduct. Depomed shall also provide to the JCC its proposed Volume Forecast on a quarterly basis
pursuant to Section&nbsp;6.3.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;The JCC shall use all reasonable efforts to review and provide comments to the Annual Plan
not later than December 1 of each preceding calendar year. Santarus will consider in good faith
any comments to the Annual Plan provided by the JCC.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Santarus shall not have any obligation to incur Sales Force Expenditures or
Advertising/Marketing/Educational Expenses in excess of the minimum amounts provided in Sections
4.1(c) and (d), respectively, of this Agreement.
</DIV>


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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) &#091;***&#093;<B>.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;Each party will bear its own operating expenses associated with the Products and Promotion
thereof, including all personnel, general and administrative and overhead costs. Santarus will
bear all Santarus Sales Force expenses, and Depomed will bear all Depomed Sales Force expenses.
Depomed will bear all costs associated with maintaining and continuing all Regulatory Approvals of
the Products in the Territory, including all costs associated with Adverse Drug Experience
reporting, filing annual reports in connection with the NDAs, user fees and establishment fees
associated with the NDAs and all clinical and regulatory requirements.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g)&nbsp;At the end of each Agreement Quarter, Santarus shall provide directly to Depomed, within
ten (10)&nbsp;business days of its receipt, the Prescriber Data for such Agreement Quarter related to
the Product, to the extent and in such form as is permitted under the applicable Third Party
agreements under which Santarus purchases the Prescriber Data.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h)&nbsp;From the Effective Date through September&nbsp;15, 2008, Depomed shall maintain, at a minimum,
the Promotion activity set forth in <U>Schedule&nbsp;4.5(h)</U>.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;4.6 <U><B>Santarus Promotion Reports</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Within forty-five (45)&nbsp;days following the end of each Agreement Quarter, Santarus shall
provide the JCC with a status report, which report will summarize Santarus&#146; Detailing activities
pursuant to this Agreement for such prior Agreement Quarter and on a calendar year-to-date basis,
including, to the extent Santarus customarily creates the following reports for Santarus&#146; other
products which are promoted by or on behalf of Santarus: (a)&nbsp;the number of P1 and P2 Details made
and recorded by Santarus&#146; standard record keeping procedures; (b)&nbsp;the names and addresses of the
Professionals called upon; (c)&nbsp;the percentage of Professionals Detailed who were provided with
Samples; (d)&nbsp;the average number of such Samples delivered on each Detail; (e)
Advertising/Marketing/Education Expenses for such Agreement Quarter; and (f)&nbsp;such other information
as may be agreed upon in writing by the parties.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) &#091;***&#093;<B>.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;4.7 <U><B>Medical Inquiries</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The parties acknowledge that each may receive requests for medical information concerning the
Product from members of the medical and paramedical professions and consumers regarding the
Product. If such requests are received by Santarus, the request will be referred to Depomed&#146;s
medical department. Depomed shall also be responsible for responding to such requests that are not
received by Santarus, all of which responses shall be in compliance with all applicable Legal
Requirements and the NDA. Depomed shall promptly provide Santarus with (i)&nbsp;copies of all written
materials and (ii)&nbsp;written summaries of all oral advice, provided by Depomed in response to such
inquiries. Depomed shall be obligated for any costs associated with its responsibilities pursuant
to this Section&nbsp;4.7; &#091;***&#093;.
</DIV>

<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

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    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;4.8 <U><B>Trademarks</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The &#147;Depomed&#148; trademark must appear on all Promotional Material that makes reference to
the Products, to the extent such Promotional Materials would typically contain a company trademark.
The &#147;AcuForm&#148; trademark must appear on all Promotional Materials that make reference to the
&#147;AcuForm&#148; drug delivery technology incorporated into the Products. Depomed hereby grants to
Santarus a non-assignable, non-sublicensable, non-exclusive, royalty-free right and license to use
the Depomed Trademarks in the Territory solely in connection with Santarus&#146; Promotion of the
Products in accordance with this Agreement; provided Santarus may assign and sublicense such right
and license in accordance with Section&nbsp;2.2. Such license shall expire immediately upon the
expiration or termination of this Agreement. Subject to this Section&nbsp;4.8 and to applicable Legal
Requirements, Santarus shall have the right to use the Santarus Trademarks, and include the name
&#147;Santarus&#148; or any variation thereof on the Promotional Materials; provided that such Santarus
Trademarks will not appear in greater prominence or in greater frequency than the Depomed
Trademarks. In addition, the JCC will discuss including the Santarus Trademarks, in equal
prominence to the Depomed Trademarks and in accordance with all Legal Requirements, on all
packaging for Samples distributed by the Santarus Sales Force, with determination by the JCC as to
including such marks being based on the timing for implementing such change and the costs
associated therewith, with all out-of-pocket costs associated with creating and approving new
packaging borne by Santarus if so approved by the JCC. Santarus recognizes Depomed&#146;s title to the
Depomed Trademarks, and shall not at any time, during or after the Term, do or knowingly suffer to
be done any act or thing which will in any way impair the rights of Depomed in or to the Depomed
Trademarks. Santarus acknowledges and agrees that it shall not acquire and shall not claim any
title to the Depomed Trademarks adverse to Depomed by virtue of the rights granted under this
Agreement or through Santarus&#146; use of the Depomed Trademarks, it being the intention of the parties
that all goodwill and improved reputation generated by Santarus and use of the Depomed Trademarks
shall inure to the benefit of Depomed.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Santarus hereby grants to Depomed a non-assignable, non-sublicensable (except to any Third
Party acting as the Depomed Sales Force), non-exclusive, royalty-free right and license to use the
Santarus Trademarks in the Territory solely in connection with Depomed&#146;s Promotion of the Products
in the Territory in accordance with this Agreement. Such license shall expire immediately upon the
expiration or termination of this Agreement. Subject to this Section&nbsp;4.8 and to applicable Legal
Requirements, Depomed shall have the right to use Depomed Trademarks, and include the name
&#147;Depomed,&#148; &#147;AcuForm,&#148; or any variation thereof on the Promotional Materials developed by Depomed in
accordance with this Agreement. Depomed recognizes Santarus&#146; title to the Santarus Trademarks, and
shall not at any time, during or after the Term, do or knowingly suffer to be done any act or thing
which will in any way impair the rights of Santarus in or to the Santarus Trademarks. Depomed
shall not be obligated to use the Santarus Trademarks in the Depomed Promotional Materials.
Depomed acknowledges and agrees that it shall not acquire and shall not claim any title to the
Santarus Trademarks adverse to Santarus by virtue of the rights granted under this Agreement or
through Depomed&#146;s use of the Santarus Trademarks, it being the intention of the parties that all
goodwill and improved reputation generated by Depomed and use of the Santarus Trademarks shall
inure to the benefit of Santarus.
</DIV>


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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Each of Santarus with respect to its use of the Depomed Trademarks and Depomed with
respect to its use of the Santarus Trademarks will maintain quality standards for all of its uses
of the trademarks of the other party in connection with the Promotion of the Products that are
substantially equivalent to those standards used by the owner of such trademarks in connection with
pharmaceutical products. Subject to the foregoing and to the other provisions of this Agreement,
each party acknowledges and agrees that the owner or licensee of the trademark has the right, at
any time, to modify or supplement such quality standards and that the licensee or sublicensee must
implement such new standards or changes following receipt of notice of such additions or changes;
provided that the licensor agrees to bear all reasonable costs associated with such modifications
and supplements. Compliance with this Section&nbsp;4.8(c) shall be determined pursuant to the
Promotional Material and Depomed Promotional Materials review and approval procedures set forth in
Sections&nbsp;4.4(b) and 4.9(f), as applicable.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;4.9 <U><B>Election by Depomed to Promote in the Territory</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Depomed may elect, at any time prior to the third (3rd) anniversary of the Effective Date,
to have the Depomed Sales Force Promote and Detail the Products directly to obstetrics and
gynecology Professionals who are on the Depomed Physician List. If Depomed desires to make this
election and to use the Depomed Sales Force for this purpose, it will inform Santarus at least
sixty (60)&nbsp;days in advance of the commencement of Details by the Depomed Sales Force and provide
Santarus with the proposed Depomed Physician List and Depomed shall commence its Promotion and
Detailing activities no later than ninety (90)&nbsp;days after the date of its notice to Santarus.
During such sixty (60)-day period, Santarus will be entitled to review the Depomed Physician List
and confirm that such list does not contain any Professionals that are not, as of the date of
Santarus&#146; receipt of the Depomed Physician List, eligible for inclusion on the Depomed Physician
List. Following creation of the initial Depomed Physician List, from time to time but not more
than two (2)&nbsp;times per calendar year, Depomed may add Professionals to the Depomed Physician List
pursuant to the procedure set forth above. Following the addition of such Professionals to the
Depomed Physician List, the Baseline Percentage shall be adjusted to reflect prescriptions written
by any such Professionals by adding to the then-current Baseline Percentage the quotient obtained
by dividing (x) &#091;***&#093;, by (y) &#091;***&#093;. Notwithstanding the foregoing, the average number of
Professionals on the Depomed Physician List shall in no event exceed &#091;***&#093; Professionals per
Depomed Sales Representative providing Details.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Depomed will submit to the JCC a call plan setting forth the Details to be performed by
the Depomed Sales Force. Such call plan may be taken into account in developing subsequent Annual
Plans. Any Professional on the Depomed Physician List who does not receive at least &#091;***&#093; Details
in each full calendar year following the commencement of Promotion of the Product by the Depomed
Sales Force will be excluded from the Depomed Physician List in subsequent calendar years for
purposes of calculating Depomed Net Sales, and for purposes of calculating the Baseline Percentage.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;All Details made by the Depomed Sales Force will be reported to Santarus. Such reports by
Depomed will be made in the same manner as Santarus&#146; Details under Section&nbsp;4.6(a). Depomed shall
be responsible for purchasing Prescriber Data relating to the Depomed Physician List at its sole
cost and expense.
</DIV>

<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Depomed may purchase from Santarus, at Santarus&#146; actual out-of-pocket costs, copies of any
Promotional Materials created by Santarus for use by the Depomed Sales Force. Upon Depomed&#146;s
request, Santarus will provide to Depomed electronic copies of Promotional Materials created by or
for Santarus, which Promotional Materials may be modified for use by Depomed; provided that any
modification must be approved as described below. Depomed may also create and develop its own
Promotional Materials for use by the Depomed Sales Force (&#147;<U>Depomed Promotional Materials</U>&#148;).
Prior to the use thereof, Depomed shall provide to Santarus a prototype of any Depomed Promotional
Materials for review. Santarus shall notify Depomed of any objections it has to such prototype and
the basis therefor as soon as reasonably practicable, but no later than ten (10)&nbsp;business days
following its receipt thereof. Depomed shall modify such Depomed Promotional Materials to the
extent necessary to resolve any objections made by Santarus to such Depomed Promotional Materials
on the grounds that such Depomed Promotional Materials are inconsistent with the overall Product
positioning and messaging for the Products and shall in good faith consider any of Santarus&#146; other
objections. The final version of the Depomed Promotional Materials shall be provided to Santarus
for its review and approval to confirm their consistency with the prototype approved by Santarus
and the resolution of Santarus&#146; objections in accordance with this Section&nbsp;4.9(d), which review and
approval shall occur, as soon as reasonably practicable, but no later than five (5)&nbsp;business days
following its receipt by Santarus. The Depomed Promotional Materials will not contain any Santarus
Trademark unless such materials are approved by the Santarus CAC. Santarus may purchase from
Depomed, at Depomed&#146;s out-of-pocket costs for printing and delivering such materials, copies of any
Depomed Promotional Materials. Upon Santarus&#146; request, Depomed will provide to Santarus electronic
copies of Depomed Promotional Materials created by or for Depomed, which Depomed Promotional
Materials may be modified for use by Santarus; provided that any modification must be approved in
the same manner as approval of Promotional Materials.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;Depomed may purchase from Santarus, at Santarus&#146; actual out-of-pocket costs, copies of
training materials developed and Controlled by Santarus related to the Products for use by Depomed
in the training of the Depomed Sales Force. Depomed shall be responsible for training of the
Depomed Sales Force, and may, at its own expense, develop training materials for the Depomed Sales
Force in other media or forms, provided that such materials shall be subject to Santarus&#146; review as
Depomed Promotional Materials as provided in Section&nbsp;4.9(d). Depomed shall, at its own expense,
train the Depomed Sales Force using such training materials, the other Promotional Materials and
Depomed Training Materials and such programs as Depomed shall deem appropriate that are in
compliance with Depomed&#146;s obligations hereunder. Such programs shall include training with respect
to reporting Adverse Drug Experiences and technical complaints. After the initial training,
Depomed shall periodically provide additional training to each Sales Representative, and shall
update its training materials as appropriate in connection with such additional training, in
accordance with this Section&nbsp;4.9(e).
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;Depomed shall be solely responsible for costs or expenses related to any activities of the
Depomed Sales Force, including costs for Depomed Promotional Materials, training or training
materials or the purchase from Santarus of Promotional Materials for the Depomed Sales Force.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g)&nbsp;Depomed will cause the Depomed Sales Force and Depomed employees and agents acting on
Depomed&#146;s behalf to comply with this Agreement and all applicable Legal
</DIV>


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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Requirements in connection with the Promotion of the Products. It is understood, and Depomed
agrees, that it will be accountable for the acts or omissions of its employees and agents to the
extent such acts or omissions fail to comply with Depomed&#146;s obligations under this Agreement.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h)&nbsp;Depomed will not make any false or misleading representations to Professionals, customers
or others regarding Santarus or the Products and will not make any representations, warranties or
guarantees with respect to the specifications, features or capabilities of the Products that are
not consistent with the applicable then-current FDA approved labeling, package insert or other
documentation accompanying or describing the Products. Depomed agrees to undertake timely and
complete corrective action for any deviations from this Section&nbsp;4.9(h).
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;4.10 <U><B>Product Website</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Unless otherwise agreed in writing by the parties, Depomed shall maintain the existing Product
website and implement any changes to such Product website, subject to the procedure set forth in
Section&nbsp;4.4 used for Promotional Materials. Santarus will reimburse Depomed for its direct
out-of-pocket costs associated with implementing any changes requested by Santarus. Such
reimbursed costs shall be included in the Advertising/Marketing/Educational Expenses for Santarus.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE V<BR>
CLINICAL AND REGULATORY AFFAIRS; DEVELOPMENT</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;5.1 <U><B>Regulatory Approvals</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Depomed shall use active, sustained, diligent efforts to maintain and continue all Regulatory
Approvals currently in effect for the Products. Santarus agrees that all Regulatory Approvals,
applications therefor and any other submissions to a Governmental Authority with respect to the
Products shall be in the name of, and shall be owned by, Depomed or its designee and Santarus shall
have access, free of charge, to all clinical and non-clinical data related to the Products
generated by or on behalf of and controlled by Depomed, whether before or after the Effective Date.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;5.2 <U><B>Compliance with Regulatory Requirements</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Unless otherwise required by law or expressly required by this Agreement, Depomed will retain
exclusive authority over and responsibility for complying with all regulatory requirements and
maintaining all contacts with Governmental Authorities with respect to the Products, including
maintaining and updating of the NDA, the development and submission of applications for new
formulations, dosage strengths or indications of the Products, the reporting of any Adverse Drug
Experiences to the FDA, the compliance of Promotional Materials with FDA rules and regulations and
the filing of Promotional Materials with the FDA.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;5.3 <U><B>Compliance</B></U>
</DIV>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In performing its duties hereunder, each party shall, and shall cause the Santarus Sales Force
or Depomed Sales Force, as applicable, and its employees and agents to, comply with all Legal
Requirements, including the FDA&#146;s regulations and guidelines concerning the advertising of
prescription drug products, DDMAC&#146;s promotional guidelines, the PhRMA Code on Interactions with
Healthcare Providers, the Prescription Drug Marketing Act of 1987, as amended, and the rules and
regulations promulgated thereunder, equal employment, non-discrimination and federal and state
anti-kickback Legal Requirements, and Legal Requirements with respect to submission of false claims
to governmental or private health care payors, which may be applicable to the activities (including
the warehousing, handling and distribution of Samples) to be performed by such party hereunder.
None of Santarus, Depomed, the Santarus Sales Force, the Depomed Sales Force and either party&#146;s
employees and agents shall offer, pay, solicit or receive any remuneration to or from Professionals
in order to induce referrals of or purchase of the Products in violation of applicable Legal
Requirements, including without limitation federal or state anti-kickback Legal Requirements. The
Santarus Sales Force and the Depomed Sales Force shall have been trained in compliance with
applicable Legal Requirements prior to engaging in Promotion of the Products.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;5.4 <U><B>Communications with Regulatory Authorities</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Except to the extent set forth in Section&nbsp;5.4(b), all communications with Government
Authorities concerning the Product shall be the sole responsibility of Depomed. Depomed shall
within two (2)&nbsp;business days provide Santarus with copies of all such communications (including
summaries of all relevant verbal communications) related to Promotional Materials and Serious
Adverse Drug Experiences (except that routine communications as to such matters (e.g., FDA 2253
correspondence) may be forwarded to Santarus within five (5)&nbsp;business days) and shall reasonably
respond to all inquiries by Santarus relating thereto. Depomed will reasonably consult with
Santarus concerning adverse drug reaction reporting to the FDA and communications related to
Promotional matters with the FDA or other Governmental Authorities that Depomed reasonably
considers to be significant to the Product, including regulatory responses to follow up inquiries
regarding adverse drug reactions. Depomed will provide to Santarus a copy of all draft responses
related to such matters as soon as practicable, and will endeavor to provide such responses at
least five (5)&nbsp;business days in advance of their submission (to the extent allowable under Legal
Requirements), and will consider in good faith any comments provided to Depomed by Santarus.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Santarus shall not, without the consent of Depomed or unless so required by Legal
Requirements, correspond or communicate with the FDA or with any other Governmental Authority,
whether within the Territory or otherwise, concerning the Products, or otherwise take any action
concerning any Regulatory Approval under which the Products are sold or any application for
Regulatory Approval of the Products; <U>provided</U> that during the Term, Santarus shall have the
right to communicate with the FDA or any other Governmental Authority regarding the Products if
such communication is necessary to comply with the terms of this Agreement or any Legal Requirement
(including without limitation state or local Legal Requirements related to marketing activities
undertaken by Santarus or the Santarus Sales Force), or if Santarus made a request of such agency
to communicate with Depomed instead, and such Governmental Authority denied such request (in any
such case, Santarus shall give Depomed notice as soon as reasonably practicable of such
communication and, to the extent practicable, Depomed shall be permitted to accompany Santarus,
take part in any such communications and receive copies of all such
</DIV>


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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">communications). Santarus shall within two (2)&nbsp;business days upon receipt of any
communication from the FDA or from any other Governmental Authority relating to the Products,
forward a copy of the same to Depomed and reasonably respond to all inquiries by Depomed relating
thereto. If Santarus is required by law to communicate with the FDA or with any other Governmental
Authority relating to the Products, then Santarus shall so advise Depomed within two (2)&nbsp;business
days and provide Depomed in advance with a copy of any proposed written communication, or a written
summary of any proposed oral communication with the FDA or any other Governmental Authority.
Santarus shall comply with any and all reasonable direction of Depomed concerning any meeting or
written or oral communication with the FDA or any other Governmental Authority relating to the
Product unless otherwise required by Legal Requirements.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;5.5 <U><B>Product Complaints</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Santarus shall refer any oral or written Product Complaints which it receives concerning the
Products to Depomed within four (4)&nbsp;days of its receipt thereof; <U>provided</U>, that all
complaints concerning suspected or actual Product tampering, contamination or mix-up shall be
delivered within twenty four (24)&nbsp;hours of its receipt thereof. Santarus shall not take any other
action in respect of any such complaint without the consent of Depomed unless otherwise required by
Legal Requirements. If requested by Depomed, Santarus will collaborate with Depomed to resolve any
Product Complaints. All Product Complaints shall be directed to the attention of Depomed&#146;s Vice
President, Regulatory Affairs, at Depomed&#146;s address set forth in Section&nbsp;14.1. Depomed shall
provide Santarus with a summary of all Product Complaints received by Depomed within ten (10)
business days of its receipt thereof; provided, however, that all complaints concerning suspected
or actual Product tampering, contamination or mix-up shall be delivered within twenty-four (24)
hours of its receipt thereof<B>.</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;5.6 <U><B>Adverse Drug Experience Reports</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Each party shall notify the other: (i)&nbsp;of all Serious Adverse Drug Experience Reports
within forty-eight (48)&nbsp;hours of the time such Serious Adverse Drug Experience Report becomes known
to such party (including its employees); and (ii)&nbsp;of all Adverse Drug Experience Reports within
five (5)&nbsp;days of the time such Adverse Drug Experience Report becomes known to such party
(including its employees).
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Except as may otherwise be required by Legal Requirements, (i)&nbsp;Santarus shall not disclose
any information concerning Adverse Drug Experience Reports or Serious Adverse Drug Experience
Reports to any Person or Governmental Authority without the prior consent of Depomed; and (ii)
Depomed shall have the sole discretion to determine whether any Product Complaint, Adverse Drug
Experience Report or Serious Adverse Drug Experience Report must be reported to the FDA or any
other Governmental Authority.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;All follow-up investigations concerning Adverse Drug Experience Reports and Serious
Adverse Drug Experience Reports shall be conducted by Depomed; <U>provided</U> that Santarus shall
have the right to participate in such investigations upon its request. Santarus shall provide all
reasonable cooperation with any such follow-up investigation as may be requested by Depomed from
time to time.
</DIV>


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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;The parties will enter into a separate and more detailed pharmacovigilance agreement,
consistent with the terms of this Agreement, reasonably in advance of the Promotion Commencement
Date.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;5.7 <U><B>Recalls or Other Corrective Action</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Depomed shall have sole responsibility for and shall make all decisions with respect to any
recall (including recall of packaging and promotion materials), market withdrawals or any other
corrective action related to the Products. Depomed shall promptly consult with Santarus with
respect to any such actions proposed to be taken by Depomed (and in all events prior to the taking
of such actions), including all actions that are reasonably likely to result in a material adverse
effect on the marketability of the Products in the Territory. At Depomed&#146;s request, Santarus shall
provide assistance to Depomed in conducting such recall, market withdrawal or other corrective
action (including retrieving Samples distributed by the Santarus Sales Force to Professionals).
With respect to any recall, market withdrawal or corrective action initiated by Depomed as a result
of Depomed becoming aware of any manufacturing defect in Products (other than Products manufactured
by Santarus in accordance with Section&nbsp;6.6), Depomed shall reimburse Santarus for its reasonable,
documented, direct, out-of-pocket costs incurred in connection with participating in such recall,
market withdrawal or other corrective action <U>provided</U> that a breach of the provisions of
this Agreement, or a violation of Legal Requirements, by Santarus is not a material cause of the
recall, market withdrawal or other corrective action. Except as set forth above, but subject to
Depomed&#146;s indemnification obligations under Section&nbsp;11.1, Depomed shall be under no liability
whatsoever to compensate Santarus or make any other payment to Santarus for any decision to recall,
initiate a market withdrawal or take any other corrective action with respect to the Products,
unless such actions results from a breach of the provisions of this Agreement or a violation of
Legal Requirements by Depomed.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;5.8 <U><B>Assistance</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each party agrees to provide to the other all reasonable assistance and take all actions
reasonably requested by the other party that are necessary to enable the other party to comply with
any Legal Requirement applicable to the Products in the Territory.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE VI<BR>
MANUFACTURING AND SUPPLY; SALES; PRICING</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;6.1 <U><B>Obligations of Depomed</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with the provisions of this Agreement and all applicable Legal Requirements,
Depomed shall, at its cost and expense, use reasonable best efforts to perform or cause to be
performed all Product manufacture, labeling, packaging, warehousing, distribution and return, order
entry, customer services and all other activities to supply and distribute the Products in the
Territory in order to fill orders for (a)&nbsp;Product conforming to the then current Volume Forecast
and (b)&nbsp;Santarus&#146; Sample requirements pursuant to Section&nbsp;6.5 in a timely and efficient manner.
Depomed shall use commercially reasonable efforts to maintain at least three (3)&nbsp;month&#146;s safety
stock of Product (&#147;<U>Safety Stock</U>&#148;) to address unanticipated changes in demand or other
manufacturing need for the Products (calculated on the basis of the then current Volume Forecast).
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Depomed shall also request that BLS continue any ongoing stability programs to support
extending the expiry dating for the 1000mg Product.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;6.2 <U><B>Manufacturing Activities</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Products, including all Samples, to be manufactured by or for Depomed for sale in the
Territory shall be manufactured to meet applicable specifications for the Products in accordance
with the NDA, cGMP and in compliance with all other applicable Legal Requirements.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;6.3 <U><B>Volume Forecasts; Wholesaler Activities</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;At least thirty (30)&nbsp;days prior to the beginning of each Agreement Quarter ending after
the Promotion Commencement Date, Santarus shall submit to the JCC a written forecast by month of
the number of units of Product expected to be prescribed in the Territory during the twelve (12)
month period beginning with such Agreement Quarter, which forecast shall be prepared by Santarus in
good faith. Depomed shall provide to Santarus trade wholesaler stocking levels information within
ten (10)&nbsp;days following the beginning of each Agreement Quarter ending after the Promotion
Commencement Date (or, if later, within two (2)&nbsp;business days after such information becomes
available to Depomed).
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;The JCC shall review and discuss such forecast and shall make such modifications thereto
as may be necessary for such forecast, to be unanimously approved by the JCC and to be consistent
with the anticipated trade demand for the Products and with the forecasting and purchasing
provisions of any applicable Third Party Product supply agreement, including the Patheon Agreement
or the BLS Supply Agreement (as so modified and approved by the JCC for the applicable twelve (12)
month period, the &#147;<U>Volume Forecast</U>&#148;).
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Depomed shall promptly inform Santarus of any back-order situations or other situations in
which wholesaler orders of the Product have not been filled (collectively, &#147;<U>Back Order
Events</U>&#148;); the parties will work together to establish a remediation plan for any such Back
Order Events. In addition, Depomed shall provide Santarus with access to general wholesaler
ordering and shipment reports, on no less frequently than a weekly basis.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;6.4 <U><B>Sales; Pricing</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Depomed or its Affiliates shall book all sales of the Products in the Territory and shall
be responsible for entering into any contracts and other arrangements with any Person regarding the
sale of the Products, and for establishing and approving the form, content and terms and conditions
thereof, including any discount, allowance, rebate, chargeback or other term granted therein;
<U>provided</U>, <U>however</U>, that (i)&nbsp;the pricing of the Products shall be consistent with
the pricing established by the JCC in accordance with Section&nbsp;3.3(i), (ii)&nbsp;the terms of such
contract and other arrangement shall be consistent with the contracting guidelines established by
the JCC in accordance with Section&nbsp;3.3(j) and reflected in the Annual Plan, with Santarus to
negotiate the rebate and chargeback amounts, the formulary position and other conditions for
Product to qualify for such rebate and chargeback amounts in compliance with the contracting
guidelines previously approved, and (iii)&nbsp;any deductions from gross amounts invoiced pursuant to
any such contract or arrangement shall correspond to one or more of the categories of deductions
</DIV>


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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">set forth in the definition of &#147;Net Sales&#148; in Article&nbsp;I. The parties agree to discuss at the
JCC and finalize the initial pricing and contracting guidelines on or before November&nbsp;1, 2008.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Santarus will work on behalf of Depomed to provide reasonably necessary support for
managed markets with respect to the Products to enable Depomed to enter into such contracts and
other arrangements described above. For purposes of clarity, all such contracts and arrangements
supported by Santarus must be executed and administered by Depomed.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;6.5 <U><B>Samples</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Depomed shall provide or cause to be provided to Santarus, as ordered by Santarus
hereunder, samples of the Products that are not for sale and with no fee associated
(&#147;<U>Samples</U>&#148;) to be distributed by Santarus solely in connection with the performance of
Details or as otherwise required by the rules, guidelines and policies applicable to any
Professional.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;At least thirty (30)&nbsp;days prior to the beginning of each Agreement Quarter ending after
the Promotion Commencement Date, Santarus shall submit to Depomed a written non-binding forecast by
month of the number of units of Samples, on a Product-by-Product basis, for the twelve (12)&nbsp;month
period beginning with such Agreement Quarter. Such sample forecast shall be consistent with
Depomed&#146;s Third Party Product supply agreements (as of the Effective Date, the Patheon Agreement
and the BLS Supply Agreement). Santarus shall place binding orders with Depomed for Samples, in a
mutually agreeable format, to the same extent as Depomed is required to place binding orders for
Samples with its Third Party Suppliers.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Depomed shall supply such Samples FOB Depomed&#146;s or its designee&#146;s warehouse, and the risk
of loss and responsibility for handling and warehousing of the Samples shall pass to Santarus upon
delivery to a carrier designated by Santarus. Santarus shall be responsible for distributing the
Samples to its Sales Representatives in a timely manner. Depomed shall invoice Santarus for each
shipment of Samples, at Depomed&#146;s out-of-pocket cost, within thirty (30)&nbsp;days of the invoice date.
Santarus shall also be responsible for securing the return and appropriate disposal of and
reconciling existing Sample inventories from discontinued Santarus Sales Representatives.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Samples supplied by Depomed to Santarus shall be used by Santarus solely in performing
Details to Professionals in accordance with this Agreement. Upon its receipt of Samples, Santarus
shall be solely responsible for accountability and compliance with the PDMA for the Santarus Sales
Force, and other applicable Legal Requirements relating to such Samples or the distribution of same
by the Santarus Sales Force, and shall be responsible for adherence by its Sales Representatives to
such Legal Requirements.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;Notwithstanding Sections&nbsp;6.5(a) and 6.5(b) hereof, Depomed agrees to supply Samples to
Santarus during the Launch Period as mutually agreed upon based upon Santarus&#146; desired requirements
and Depomed&#146;s available inventory and scheduled receipts from the Sample manufacturers.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;All Samples supplied to Santarus under this Agreement with approved expiry dating of 30
months or greater will have a minimum shelf life of 24&nbsp;months at time of
</DIV>


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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">shipment to Santarus, and all Samples supplied to Santarus under this Agreement with approved
expiry dating of less than 30&nbsp;months will be shipped to Santarus within 6&nbsp;months of the start of
manufacture.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g)&nbsp;Depomed shall promptly reimburse Santarus for the cost of any Samples purchased by
Santarus, to the extent that such Samples are unusable as a result of Depomed&#146;s failure to
manufacture and supply such Samples in all material respects in accordance with this Agreement.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;6.6 <U><B>Manufacturing Matters; Inability to Supply</B></U>.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Depomed shall promptly inform Santarus in the event that Depomed becomes aware of any
matters which might reasonably be expected to: (i)&nbsp;result in a breach of Section&nbsp;6.2 hereof; or
(ii)&nbsp;have an adverse impact on the ability to supply trade Products or Samples in a timely manner.
In each such event, Depomed shall provide Santarus with a reasonable opportunity to participate
directly in discussions with Depomed&#146;s Third Party manufacturers of Products concerning the
investigation and resolution of such matters. Notwithstanding the generality of the foregoing,
Depomed agrees to notify Santarus within twenty-four (24)&nbsp;hours after Depomed has become aware of
any event or circumstance related to the manufacture of the Product that might reasonably be
expected to impact the safety or efficacy of Product that has been released by Depomed or that
might reasonably be expected to cause such released Product to be adulterated or misbranded within
the meaning of the Act.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;In the event that a Depomed Supply Failure occurs, notwithstanding its compliance with its
obligations under Section&nbsp;6.1, Depomed shall diligently exercise its back-up manufacturing rights.
In the event that Depomed is not diligently exercising its back-up manufacturing rights, upon
written notice to Depomed (a &#147;<U>Santarus Manufacturing Notice</U>&#148;), Santarus shall have, and
Depomed hereby grants Santarus, exercisable only in accordance with the provisions hereof, the
right, but not the obligation, to manufacture, or have manufactured, the Product on behalf of
Depomed, at Depomed&#146;s expense, including expenses related to the technical transfer of the Product,
and Depomed will provide reasonable assistance to Santarus in connection therewith, including by
transferring or licensing to Santarus all Technology necessary or useful to give Santarus the
capability of manufacturing the Product so that Santarus can undertake manufacture of the Product.
Any such Product manufactured by Santarus will be sold by Depomed in accordance with this
Agreement. &#091;***&#093;.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;6.7 <U><B>Third Party Agreements</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The parties acknowledge that Depomed is subject to certain rights and obligations under
the BLS Agreements. Depomed shall not amend, terminate or cause to be terminated any of the BLS
Agreements (or any other agreement between Depomed and BLS concerning rights to, or the supply or
marketing of, a Product in the Territory) without the prior written consent of Santarus, which
consent shall not to be unreasonably withheld, delayed or conditioned; provided that Depomed shall
have the right to amend any such BLS Agreement without the consent of Santarus if such amendment
does not materially and adversely affect (i)&nbsp;Depomed&#146;s ability to maintain Regulatory Approval for
the applicable Product, (ii)&nbsp;Depomed&#146;s ability to purchase the applicable Product in commercial
quantities under the BLS Supply
</DIV>

<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>
</TABLE>

<P align="center" style="font-size: 10pt"><!-- Folio -->30<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Agreement, (iii)&nbsp;Santarus&#146; economic benefits hereunder, including the BLS Fees or COGS, or
(iv)&nbsp;the applicable lead-time and forecasting requirements. In the event of any failure by BLS to
timely deliver and supply the 1000mg Product under the BLS Supply Agreement in accordance with the
terms thereof, Depomed shall promptly pursue any recourse it may have under such BLS Agreement to
remedy such failure. In such event, Depomed&#146;s liability to Santarus for such failure shall be
limited to the recourse that Depomed receives, if any, from BLS, and any such failure on the part
of BLS shall not be a breach or default of this Agreement by Depomed (except to the extent that any
such failure by BLS arises directly from Depomed&#146;s failure to comply with its obligations,
including paying amounts due, under the BLS Supply Agreement). If requested by Santarus and after
consultation with Santarus, Depomed will request that BLS agree to modify certain provisions of the
BLS Supply Agreement relating to ordering and forecasting matters.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;The parties acknowledge that Depomed is subject to certain rights and obligations under
the Patheon Agreement. Depomed shall not amend, terminate or cause to be terminated the Patheon
Agreement (or any other agreement between Depomed and Patheon concerning rights to, or the supply
or marketing of, a Product in the Territory) without the prior written consent of Santarus, which
consent shall not to be unreasonably withheld, delayed or conditioned; provided that Depomed shall
have the right to amend the Patheon Agreement without the consent of Santarus if such amendment
does not materially and adversely affect (i)&nbsp;Depomed&#146;s ability to maintain Regulatory Approval for
the applicable Product (ii)&nbsp;Depomed&#146;s ability to purchase the applicable Product in commercial
quantities under the Patheon Agreement, (iii)&nbsp;Santarus&#146; economic benefits hereunder, or (iv)&nbsp;the
applicable lead-time and forecasting requirements. In addition, upon Santarus&#146; request, Depomed
shall exercise any of its rights under the Patheon Agreement reasonably necessary to ensure
continued supply of the applicable Product in the Territory.
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE VII<BR>
COMPENSATION</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;7.1 <U><B>Santarus Payments</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;In consideration for Santarus&#146; future share of the Gross Margin in respect of the current
500mg Product Net Sales established by Depomed prior to the Effective Date, Santarus shall pay to
Depomed a one-time signing payment of Twelve Million Dollars ($12,000,000), payable on the
Effective Date.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;In consideration for the rights granted to Santarus hereunder, Santarus shall pay to
Depomed the following one-time milestone payments:
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;&#091;***&#093; Dollars ($&#091;***&#093;) when aggregate Promotion Net Sales in any calendar year during the
Term exceed &#091;***&#093; Dollars ($&#091;***&#093;);
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;&#091;***&#093; Dollars ($&#091;***&#093;) when aggregate Promotion Net Sales in any calendar year during the
Term exceed &#091;***&#093; Dollars ($&#091;***&#093;);
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;&#091;***&#093; Dollars ($&#091;***&#093;) when aggregate Promotion Net Sales in any calendar year during
the Term exceed &#091;***&#093; Dollars ($&#091;***&#093;); and
</DIV>

<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>
</TABLE>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv)&nbsp;&#091;***&#093; Dollars ($&#091;***&#093;) when aggregate Promotion Net Sales in any calendar year during the
Term exceed &#091;***&#093; Dollars ($&#091;***&#093;).
</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Payments under Section&nbsp;7.1(b) shall be made within thirty (30)&nbsp;days after receiving from Depomed a
statement pursuant to Section&nbsp;7.2(b) indicating that such aggregate Promotion Net Sales levels have
been achieved.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;7.2 <U><B>Promotion Fees</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;In consideration for Santarus&#146; performance of its obligations under this Agreement,
beginning with the Agreement Month ending on October&nbsp;31, 2008, Depomed shall pay promotion fees
(the &#147;<U>Promotion Fees</U>&#148;) to Santarus as follows:
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;Beginning on the Promotion Commencement Date and continuing for &#091;***&#093; Agreement Quarters
thereafter, Depomed shall pay to Santarus &#091;***&#093; percent (&#091;***&#093;%) of the Gross Margin;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;Thereafter during the Term, Depomed shall pay to Santarus &#091;***&#093; &#091;***&#093; percent (&#091;***&#093;%) of
the Gross Margin;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;Beginning on the Promotion Commencement Date and continuing for &#091;***&#093; Agreement Quarters
thereafter, Depomed shall pay to Santarus &#091;***&#093; percent (&#091;***&#093;%) of the Depomed Gross Margin; and
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv)&nbsp;Thereafter during the Term, Depomed shall pay to Santarus &#091;***&#093; percent (&#091;***&#093;%) of the
Depomed Gross Margin.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Within &#091;***&#093; days following the end of each Agreement Month during the Term, Depomed shall
provide Santarus with a statement in a mutually agreeable format setting forth:
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;the aggregate number of units of Product (on a Product-by-Product basis) sold to customers
in the Territory during such Agreement Month;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;Net Sales during such Agreement Month;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;Depomed Net Sales during such Agreement Month, if any;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv)&nbsp;BLS Fees during such Agreement Month;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v)&nbsp;COGS during such Agreement Month;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi)&nbsp;Medical Affairs Expenses during such Agreement Month; and
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii)&nbsp;Gross Margin for such Agreement Month.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Within &#091;***&#093; days following the end of each Agreement Month (or if later, within two (2)
business days after such information becomes available to Depomed) during the
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->32<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">





<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Term, Depomed shall provide Santarus with a statement setting forth the aggregate number of
units of Product sold to customers in the Territory during such Agreement Month.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Except as expressly specified otherwise, any amounts payable by one party to the other
party in respect of any Agreement Month pursuant to this Agreement shall be paid within thirty (30)
days after the end of such Agreement Month. Statements required to be provided to Santarus under
this Section&nbsp;7.2 shall be emailed to such email addresses as Santarus may from time to time
designate in writing.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;In the event that Promotion Fees payable to Santarus under this Agreement for a particular
period is a negative number, Santarus will not be required to make a payment to Depomed equal to
the negative Promotion Fees, and Depomed shall credit an amount equal to any negative Promotion
Fees against any future payments due to Santarus under this Agreement.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;7.3 <U><B>Maintenance of Records</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Each party agrees to keep, for a period of at least three years after the date of entry
(or such longer period as may be required by Legal Requirements) full and accurate records
maintained in accordance with such party&#146;s accounting practices in sufficient detail to enable a
Third Party to accurately calculate (i)&nbsp;in the case of Depomed, COGS, BLS Fees, Medical Affairs
Expenses, Net Sales and Depomed Net Sales reported, payments to be made under this Agreement and
Details completed by the Depomed Sales Force, if any, and (ii)&nbsp;in the case of Santarus,
Advertising/Marketing/Educational Expenses, Sales Force Expenditures (i.e., Details completed by
the Santarus Sales Force, including as to each Detail whether it was a P1 Detail or P2 Detail) and,
with respect to the first twelve (12)&nbsp;months following the Promotion Commencement Date, Details,
including as to each Detail whether it was a P1 Detail or P2 Detail, completed by the Santarus
Sales Force. Upon thirty (30)&nbsp;days prior written notice, such records shall be made available by
the audited party for audit by an independent certified public accounting firm designated by the
other party and reasonably acceptable to the party whose records are to be examined. The auditor
will only examine such books and records during business hours but not more than once each fiscal
year while this Agreement remains in effect and for three years thereafter in order to verify
expenses, COGS, BLS Fees, Medical Affairs Expenses, Gross Margin, Net Sales, Depomed Net Sales or
such Details completed, or payments due under this Agreement. The fees and expenses of the auditor
performing such verification examination shall be borne by the party conducting the verification;
<U>provided</U>, <U>however</U>, that if any verification reveals that the audited party has
reported incorrectly, and the amount of such discrepancy is at least five percent (5%) of the
aggregate amount that should have been reported for the period examined, then the audited party
shall pay the entire amount of the fees and expenses for such verification.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Each party shall have the right, upon ten (10)&nbsp;business days&#146; prior written notice, to
audit all applicable records of the other party (other than records described in Section&nbsp;7.3(a))
for the purpose of determining the audited party&#146;s compliance with the obligations set forth in
this Agreement, including with respect to training programs and certifications and records and
reports for the Samples. The audit will be conducted during normal business hours, at convenient
times. Any such audit may be conducted no more than once each fiscal year. The fees and expenses
of the auditing party shall be borne by such party. This right to audit shall extend
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">throughout
the term of this Agreement and for one year after expiration or termination of this Agreement.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Whenever in this Agreement a party is required to report its costs, or is entitled to
receive or obligated to make a payment based on its costs, such costs (including COGS, Medical
Affairs Expenses and Advertising/Marketing/Educational Expenses) shall be determined in accordance
with generally accepted accounting principles as applied in the United States (&#147;<U>GAAP</U>&#148;),
consistent with the terms of this Agreement. The term &#147;out-of-pocket&#148; costs or expenses means cost
or expenses paid to Third Parties and shall not include any fixed costs or expenses, personnel
costs or expenses, overhead costs or expenses, or other costs or expenses of a similar nature.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;7.4 <U><B>Payments</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any payments required to be made by either party under this Agreement shall be made in United
States dollars via wire transfer of immediately available funds to such bank account as the other
party shall designate in writing prior to the date of such payment. All payments shall bear
interest from the date due until paid at a rate equal to the prime rate effective for the date that
payment was due plus eight percent (8%), as quoted by the <I>Wall Street Journal</I>, New York Edition, on
the date such payment was due, or, if less, the maximum rate permitted by applicable law.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;7.5 <U><B>Tail Promotion Fees</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Following the termination of this Agreement at the conclusion of the initial three (3)&nbsp;years
of the Term or thereafter, for each of the &#091;***&#093; full calendar quarters following such termination,
Depomed shall pay to Santarus an amount equal to &#091;***&#093; percent (&#091;***&#093;%) of aggregate Net Sales for
each such quarter (excluding any Depomed Net Sales as of the effective termination date).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;7.6 <U><B>Depomed Percentage</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If, prior to or following the commencement of Product Promotion by the Depomed Sales Force,
either party reasonably determines that the Prescriber Data fails to, or is likely to fail to,
reasonably accurately reflect the portion of Net Sales attributable to prescriptions written by
Professionals on the Depomed Physician List (whether as a result of Professionals opting out of the
American Medical Association&#146;s Physician Masterfile database or otherwise), the parties shall
negotiate in good faith with respect to implementing a revised manner of measuring the portion of
Net Sales attributable to prescriptions written by Professionals on the Depomed Physician List, and
reflect any such modification in the definition of &#147;Depomed Percentage&#148; and the &#147;Baseline
Percentage.&#148; The parties shall consider in their discussions any other customary manner of
determining similar information as may arise in light of Professionals opting out of the
American Medical Association&#146;s Physician Masterfile database or otherwise.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE VIII<BR>
TERM AND TERMINATION</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;8.1 <U><B>Term</B></U>
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

</TABLE>


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<DIV style="font-family: 'Times New Roman',Times,serif">






<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The term of this Agreement shall commence on the Effective Date and shall continue, unless
terminated sooner in accordance with this Article&nbsp;VIII, until the expiration of the last-to-expire
patent or patent application with a Valid Claim in the Territory covering a Product or its uses
(the &#147;<U>Term</U>&#148;).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;8.2 <U><B>Early Termination</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Depomed may terminate this Agreement, at any time after providing sixty (60)&nbsp;days&#146; prior
written notice, in the event that Santarus fails to meet its obligations under Section&nbsp;4.1(b), (c)
or (d)&nbsp;with respect to minimum Promotion obligations. Notwithstanding the foregoing, Santarus
shall have an opportunity to cure any such breach within ninety (90)&nbsp;days following written notice
from Depomed provided that: (i)&nbsp;Santarus has complied with at least ninety percent (90%) of the
aggregate obligations in effect under such Sections during the relevant time period; and (ii)&nbsp;no
other breach of the obligations set forth in Sections&nbsp;4.1(b), (c)&nbsp;or (d)&nbsp;has occurred within the
prior twelve (12)&nbsp;month period.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Santarus may terminate this Agreement for any reason upon ninety (90)&nbsp;days&#146; prior written
notice; provided, however, that the effective date for such termination may not occur prior to
eighteen (18)&nbsp;months following the Effective Date.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Santarus may terminate this Agreement immediately upon written notice to Depomed in the
event of (i)&nbsp;any action taken or objection raised by any Governmental Authority that prevents
Santarus from performing its obligations under this Agreement or otherwise makes such activity
unlawful, (ii)&nbsp;loss of a Product&#146;s market exclusivity in the Territory (whether through the
introduction of a generic product or otherwise), or (iii)&nbsp;Depomed&#146;s failure to supply Product
reasonably necessary to meet trade demand for the Product and consistent with the then-current
Volume Forecast, which failure continues for a period of three (3)&nbsp;months or longer.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Either party shall have the right to terminate this Agreement immediately in the event of
a large scale recall or withdrawal of the Product from the Territory resulting from a significant
safety risk inherent in the Product and not due to tampering, a remediable
manufacturing problem, or other defect that can be cured with respect to Products manufactured
after such risk is discovered.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;Depomed shall have the right to terminate this Agreement upon one hundred eighty (180)
days&#146; prior written notice if Santarus fails to timely deliver the written confirmation related to
Sales Force Expenditures required by Section&nbsp;4.5(e) (provided that if such failure is cured within
thirty (30)&nbsp;days following receipt of Depomed&#146;s notice, such notice with respect to such
termination shall be null and void).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;8.3 <U><B>Termination for Cause</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Either party may terminate this Agreement, effective at any time after providing sixty (60)
days written notice and an opportunity to cure during such sixty (60)-day period (ninety (90)&nbsp;days
in the case of a breach by Depomed of Section&nbsp;6.1), in the event of a material failure of the other
party to comply with its material obligations contained in this Agreement. If such cure is
effected, such notice with respect to such termination shall be null and void.
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->35<!-- /Folio -->
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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;8.4 <U><B>Termination for Bankruptcy or Force Majeure</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To the extent permitted by law, each party will have the right to terminate this Agreement
immediately upon notice to the other party, in the event of either of the following:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The entry of an order for relief under the United States Bankruptcy Code (or any
corresponding remedy under successor laws) against the other party; the filing of a petition by or
against the other party under any bankruptcy, insolvency or similar law (which petition is not
dismissed within sixty (60)&nbsp;days after filing), except Chapter&nbsp;11 of the United States Bankruptcy
Code or any successor statute that permits a corporation to continue its operation while protecting
it from creditors; the appointment of a receiver for the other party&#146;s business or property; or the
other party&#146;s making of a general assignment for the benefit of its creditors; or
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Any Force Majeure Event affecting the other party beyond the other party&#146;s control which
lasts for a period of at least six (6)&nbsp;months and which is of sufficient intensity to interrupt or
prevent the carrying out of such other party&#146;s material obligations under this Agreement during
such period.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Notwithstanding the occurrence of any of the events specified in subsection (a)&nbsp;of this Section
8.4, the parties acknowledge and agree that, to the extent Section 365(n) of the United States
Bankruptcy Code applies to this Agreement, the non-insolvent party may elect to retain and exercise
the rights granted to it hereunder with respect to the intellectual property owned or controlled by
the insolvent party.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;8.5 <U><B>Force Majeure</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any Force Majeure Event of the type described in Section&nbsp;16.7 affecting a party hereunder
shall entitle the other party hereto, at any time after the expiry of the period of six (6)&nbsp;months
specified therein and upon sixty (60)&nbsp;days written notice given after such six (6)-month period
(such notice being null and void if the Force Majeure Event is
discontinued during such sixty (60)-day period), in addition to the right to terminate this Agreement under Section&nbsp;8.4, the
right to continue the Agreement in full force and effect without modification. In no circumstances
will either party be liable to the other for its inability to perform under this Agreement due to
any such Force Majeure Event.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;8.6 <U><B>Effect of Termination</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;No additional payment obligations arising under Article&nbsp;VII hereof shall accrue after the
date of expiration or termination of this Agreement except as set forth in Section&nbsp;7.5;
<U>provided</U>, <U>however</U>, that expiration or termination of this Agreement shall not
relieve either party of any obligations accruing prior to such expiration or termination. Certain
provisions of this Agreement by their terms continue after the expiration or termination of this
Agreement, including Sections&nbsp;3.5, 4.4(d), 5.5, 5.6, 7.3, 7.4, 7.5, this Section&nbsp;8.6, 15.1 and
Articles XI and XII and solely with respect to the reports required for the Final Agreement
Quarter, Sections&nbsp;4.5(g) and 4.6(a). In addition, any other provisions required to interpret and
enforce the parties&#146; rights and obligations under this Agreement shall also survive, but only to
the extent required for the full observation and performance of this Agreement.
</DIV>


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</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Except as indicated in Section&nbsp;8.5, expiration or termination of this Agreement shall be
without prejudice to (i)&nbsp;any remedies which any party may then or thereafter have hereunder or at
law or in equity; and (ii)&nbsp;a party&#146;s right to receive any payment accrued under the Agreement prior
to the termination date but which became payable thereafter; and (iii)&nbsp;either party&#146;s right to
obtain performance of any obligations provided for in this Agreement which survive termination by
their terms or by a fair interpretation of this Agreement. Except as expressly set forth herein,
the rights to terminate as set forth herein shall be in addition to all other rights and remedies
available under this Agreement, at law, or in equity or otherwise.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Upon the expiration or termination of this Agreement pursuant to this Article&nbsp;VIII, each
party shall promptly transfer and return to the other party all Proprietary Information of the
other party (provided that each party may keep one copy of such Proprietary Information for
archival purposes only). Upon the expiration or termination of this Agreement, Santarus shall, if
requested by Depomed, provide to Depomed all Promotional Materials in Santarus&#146; possession
(including electronic files of all Promotional Materials) at Santarus&#146; out-of-pocket cost for
printing and delivering such materials; <U>provided</U>, <U>however</U>, that Santarus shall,
unless otherwise requested by Depomed, destroy any printed copies of Promotional Materials bearing
the Santarus Trademarks and may remove the Santarus Trademarks from electronic files of Promotional
Materials.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Upon the expiration or termination of this Agreement pursuant to this Article&nbsp;VIII other
than pursuant to Depomed&#146;s termination under Sections&nbsp;8.3 or 8.4, Depomed may, but is not obligated
to, purchase from Santarus, at Santarus&#146; cost (as determined pursuant to this Agreement) all
remaining Samples; provided, however, that Depomed shall be obligated to purchase such Samples from
Santarus in the event that this Agreement is terminated pursuant to Section&nbsp;8.3 for Depomed&#146;s
breach.
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE IX<BR>
REPRESENTATIONS AND WARRANTIES</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;9.1 <U><B>Representations and Warranties of Depomed</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Depomed hereby represents and warrants to Santarus as of the date hereof as follows:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;<U>Organization</U>. Depomed (i)&nbsp;is a corporation duly organized, validly existing and
in good standing under the laws of the state of California, and (ii)&nbsp;has all necessary corporate
power and corporate authority to own its properties and to conduct its business, as currently
conducted.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;<U>Authorization</U>. The execution and delivery of this Agreement and the consummation
of the transactions contemplated hereby are within the corporate power of Depomed, have been duly
authorized by all necessary corporate proceedings of Depomed, and this Agreement has been duly
executed and delivered by Depomed.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;<U>No Conflict</U>. The execution and delivery of this Agreement and the consummation of
the transactions contemplated hereby do not: (i)&nbsp;conflict with or result in a breach of any
provision of Depomed&#146;s organizational documents; (ii)&nbsp;result in a material breach of
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">any material
agreement to which Depomed is party; (iii)&nbsp;result in a violation of any Order to which Depomed is
subject; (iv)&nbsp;require Depomed to obtain any material approval or consent from any Governmental
Authority or Third Party other than those consents and approvals which have been obtained prior to
the date hereof; or (v)&nbsp;violate any Legal Requirement applicable to Depomed in any material
respect.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;<U>Enforceability</U>. This Agreement constitutes the valid and binding obligation of
Depomed, enforceable against Depomed in accordance with its terms, subject to bankruptcy,
reorganization, insolvency and other similar laws affecting the enforcement of creditors&#146; rights in
general and to general principles of equity (regardless of whether considered in a proceeding in
equity or an action at law).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;<U>Broker</U>. Depomed has not employed any broker, finder, or agent with respect to
this Agreement or the transactions contemplated hereby.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;<U>Depomed Intellectual Property</U>. To the knowledge of Depomed, the Promotion and
sale of Product in the Territory in accordance with this Agreement will not infringe any patents,
trademarks or other intellectual property rights of any Third Party; provided, that Depomed makes
no representation as to the Santarus Trademarks. Depomed has the right, power and authority to
grant the licenses granted by it hereunder, including the right, power and authority to license to
Santarus, pursuant to Section&nbsp;6.6, all Technology necessary for the manufacture of the Products.
Other than &#091;***&#093;: (i)&nbsp;Depomed has not received any written claim or demand from any Third Party
alleging that any infringement, violation or misappropriation of such Third Party&#146;s intellectual
property rights has occurred as a result of the manufacture, use, offer for sale, sale or
importation of any Product in the Territory; (ii)&nbsp;Depomed is not aware of any actual, alleged or
threatened infringement, violation or misappropriation by a Third Party of any Depomed intellectual
property rights covering a Product or its uses; and (iii)&nbsp;Depomed has not
received any written claim or demand from any Third Party alleging invalidity or
unenforceability of any patents or patent applications owned or licensed by Depomed covering a
Product or its uses.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g)&nbsp;<U>Litigation</U>. There is no litigation, arbitration proceeding, governmental
investigation, action or claims of any kind, pending or, to the knowledge of Depomed, threatened,
by or against Depomed, BLS, Patheon or any of their respective Affiliates relating to the Products
or which would reasonably be expected to materially affect Depomed&#146;s ability to perform its
obligations hereunder.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h)&nbsp;<U>Documentation</U>. Depomed has made available to Santarus copies of substantially all
clinical data and reports, medical information, competitive information, marketing research,
agreements and other documentation related to the Products in Depomed&#146;s possession that have been
requested by Santarus in the course of Santarus&#146; due diligence investigation of the Products.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;<U>Supply</U>. Depomed currently has access to sufficient supplies of Products to
satisfy the manufacturing obligations required by it under this Agreement. All Products will be
manufactured with reasonable due care and in conformity with the NDAs, current generally
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

</TABLE>


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<DIV style="font-family: 'Times New Roman',Times,serif">





<DIV align="left" style="font-size: 10pt; margin-top: 6pt">accepted standards and procedures for manufacturing the Products, cGMP and all other
applicable Legal Requirements.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j)&nbsp;<U>Generic Drug Act</U>. Pursuant to the Generic Drug Enforcement Act of 1992, 21 U.S.C.
&#167; 335a, as may be amended or supplemented (the &#147;<U>Generic Drug Act</U>&#148;),
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;none of Depomed, its Affiliates, or any Person under its direction or control is currently
debarred by the FDA under the Generic Drug Act;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;none of Depomed, its Affiliates, or any Person under its direction or control is
currently using or will use in any capacity in connection with the Products any Person that is
debarred by FDA under the Generic Drug Act; and
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;there have been no convictions of Depomed, its Affiliates, or any Person under its
direction or control for any of the types of crimes set forth in the Generic Drug Act within the
five years prior to the Effective Date.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k)&nbsp;<U>Legal Requirements</U>. None of Depomed, its Affiliates, or any Person under its
direction or control is currently excluded from a federal or state health care program under
Sections&nbsp;1128 or 1156 of the Social Security Act, 42 U.S.C. &#167;&#167; 1320a-7, 1320c-5 as may be amended
or supplemented. None of Depomed, its Affiliates, or Person under its direction or control is
otherwise currently excluded from contracting with the federal government. None of
Depomed, its Affiliates, or Person under its direction or control is otherwise currently
excluded, suspended, or debarred from any federal or state program. Depomed shall immediately
notify Santarus if, at any time during the Term, Depomed, its Affiliates, or any Person under its
direction or control is convicted of an offense that would subject it or Santarus to exclusion,
suspension, or debarment from any federal or state program. To Depomed&#146;s knowledge, the
manufacture, use, offer for sale, sale and importation of the Products in the Territory has been in
material compliance with all Legal Requirements.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l)&nbsp;<U>NDA Acquisition</U>. Depomed has not committed fraud in relation to the filing or
acquisition of an NDA or used unfair methods of competition in connection with such filing or
acquisition, including, in either case, in connection with any data supplied by Depomed to the FDA.
The parties acknowledge that a breach of this representation is a material failure of a material
obligation and is not subject to cure. The data regarding the efficacy and safety of the Products
contained in the NDAs and other regulatory filings submitted to the FDA in support of marketing
approval of the Products are complete and accurate in all material respects. The NDAs and other
regulatory filings submitted to the FDA in support of marketing approval for the Products do not
contain any material misstatement of a material fact related to safety or efficacy nor omit to
state any material fact in Depomed&#146;s possession related to safety or efficacy.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m)&nbsp;<U>BLS Agreements</U>. Depomed is not in material breach of any BLS Agreement and has
not submitted to BLS any notice (written or oral) to the effect that BLS is in breach of any BLS
Agreement. Depomed has not received from BLS any notice (written or oral) to the effect that
Depomed is in breach of any BLS Agreement. Each of the BLS Agreements is legal, valid, binding,
enforceable and in full force and effect in all material respects.
</DIV>

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</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(n)&nbsp;<U>Patheon Agreement</U>. Depomed is not in material breach of the Patheon Agreement and
has not submitted to Patheon any notice (written or oral) to the effect that Patheon is in breach
of the Patheon Agreement. Depomed has not received from Patheon any notice (written or oral) to
the effect that Depomed is in breach of the Patheon Agreement. The Patheon Agreement is legal,
valid, binding, enforceable and in full force and effect in all material respects.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(o)&nbsp;<U>Inventory Levels</U>. Since January&nbsp;1, 2008, Depomed has not (i)&nbsp;materially altered
its distribution practices or terms with respect to the Products (other than pricing increases in
the ordinary course of business), (ii)&nbsp;altered its activities and practices with respect to
inventory levels of the Products maintained at the wholesale, chain, institutional or retail levels
in any material respect, or (iii)&nbsp;experienced abnormally high levels of returns of the Products
when compared to historical norms.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;9.2 <U><B>Representations and Warranties of Santarus</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Santarus hereby represents and warrants to Depomed as of the date hereof as follows:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) <U>Organization</U>. Santarus (i)&nbsp;is a corporation duly organized, validly existing and
in good standing under the laws of the state of Delaware, and (ii)&nbsp;has all necessary corporate
power and corporate authority to own its properties and to conduct its business, as currently
conducted.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) <U>Authorization</U>. The execution and delivery of this Agreement and the consummation
of the transactions contemplated hereby are within the corporate power of Santarus, have been duly
authorized by all necessary corporate proceedings of Santarus, and this Agreement has been duly
executed and delivered by Santarus.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) <U>No Conflict</U>. The execution and delivery of this Agreement and the consummation of
the transactions contemplated hereby do not: (i)&nbsp;conflict with or result in a breach of any
provision of Santarus&#146; organizational documents; (ii)&nbsp;result in a material breach of any material
agreement to which Santarus is party; (iii)&nbsp;result in a violation of any Order to which Santarus is
subject; (iv)&nbsp;require Santarus to obtain any material approval or consent from any Governmental
Authority or Third Party other than those consents and approvals which have been obtained prior to
the date hereof; or (v)&nbsp;violate any Legal Requirement applicable to Santarus in any material
respect.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) <U>Enforceability</U>. This Agreement constitutes the valid and binding obligation of
Santarus, enforceable against Santarus in accordance with its terms, subject to bankruptcy
reorganization, insolvency and other similar laws affecting the enforcement of creditors&#146; rights in
general and to general principles of equity (regardless of whether considered in a proceeding in
equity or an action at law).
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) <U>Broker</U>. Santarus has not employed any broker or finder with respect to this
Agreement or the transactions contemplated hereby.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) <U>Santarus Trademarks</U>. To the knowledge of Santarus, the use of the Santarus
Trademarks to Promote and sell Products in the Territory in accordance with this
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Agreement will not
infringe any trademarks or other intellectual property rights of any Third Party.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) <U>Litigation</U>. There is no litigation, arbitration proceeding, governmental
investigation, action or claims of any kind, pending or, to the knowledge of Santarus, threatened,
by or against Santarus or any of its Affiliates relating to the Products or which would reasonably
be expected to materially affect Santarus&#146; ability to perform its obligations hereunder.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) <U>Generic Drug Act</U>. Pursuant to the Generic Drug Act,
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;none of Santarus, its Affiliates, or any Person under its direction or control is
currently debarred by the FDA under the Generic Drug Act;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;none of Santarus, its Affiliates, or any Person under its direction or control is
currently using or will use in any capacity in connection with the Products any Person that is
debarred by FDA under the Generic Drug Act; and
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;there have been no convictions of Santarus, its Affiliates, or any Person under its
direction or control for any of the types of crimes set forth in the Generic Drug Act within the
five years prior to the Effective Date.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) <U>Legal Requirements</U>. None of Santarus, its Affiliates, or any Person under its
direction or control is currently excluded from a federal or state health care program under
Sections&nbsp;1128 or 1156 of the Social Security Act, 42 U.S.C. &#167;&#167; 1320a-7, 1320c-5 as may be amended
or supplemented. None of Santarus, its Affiliates, or any Person under its direction or control is
otherwise currently excluded from contracting with the federal government. None of Santarus, its
Affiliates, or Person under its direction or control is otherwise currently excluded, suspended, or
debarred from any federal or state program. Santarus shall immediately notify Depomed if, at any
time during the Term, Santarus, its Affiliates, or any Person under its direction or control is
convicted of an offense that would subject it or Depomed to exclusion, suspension, or debarment
from any federal or state program.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;9.3 <U><B>Depomed Disclaimer</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EXCEPT AS EXPRESSLY PROVIDED HEREIN, DEPOMED DISCLAIMS ALL OTHER WARRANTIES, EXPRESS OR
IMPLIED, WITH REGARD TO THE PRODUCTS, INCLUDING THE WARRANTY OF MERCHANTABILITY AND WARRANTY OF
FITNESS FOR A PARTICULAR PURPOSE.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;9.4 <U><B>Santarus Disclaimer</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EXCEPT AS EXPRESSLY PROVIDED HEREIN, SANTARUS DISCLAIMS ALL OTHER WARRANTIES, EXPRESS OR
IMPLIED, INCLUDING THE WARRANTY OF MERCHANTABILITY AND WARRANTY OF FITNESS FOR A PARTICULAR
PURPOSE.
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE X<BR>
INTELLECTUAL PROPERTY MATTERS</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;10.1 <U><B>Intellectual Property Prosecution and Maintenance</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Depomed shall use commercially reasonable efforts to prosecute and maintain the Depomed
intellectual property in the Territory related to any Product Promoted pursuant to this Agreement
(a &#147;<U>Promoted Product</U>&#148;) or its use, including patents, the Depomed Trademarks and any
copyrights associated with the Promotional Materials (subject, in the case of the 1000mg Product,
to Depomed&#146;s rights in respect of intellectual property under the BLS Agreements). Depomed shall
make available to Santarus (or its designated counsel) copies of such patent application files and
shall make available to Santarus (or its designated counsel) all office actions relating to any
Promoted Product wherein at least one (1)&nbsp;claim is directed to the Promoted Product in those patent
applications, and copies of material correspondence with the U.S. Patent and Trademark Office
relating to such patent applications to the extent they relate to the Promoted Product or its use.
Santarus shall have the right to comment upon the prosecution of such patent applications (subject,
in the case of the 1000mg Product, to Depomed&#146;s rights in respect of intellectual property under
the BLS Agreements). Depomed shall, in good faith, consider such comments of Santarus. In
addition, Depomed shall keep Santarus reasonably informed regarding material developments relating
to the prosecution, maintenance or enforcement of Depomed&#146;s intellectual property rights related to
any Promoted Product outside the Territory that could reasonably be expected to have a material
impact on Depomed&#146;s intellectual property rights related to the Promoted Product in the Territory.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;10.2 <U><B>Third Party Competition</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Nothing in this Agreement shall limit or restrict Depomed&#146;s ability to grant non-exclusive
patent licenses to patents and patent applications included within the Technology or otherwise
covering a Product in connection with the settlement of any pending, threatened or contemplated
patent litigation with respect to &#091;***&#093; commercialized in the Territory prior to the Effective Date
(each such license, a &#147;<U>Patent License</U>&#148;). However, in recognition of the parties&#146; agreement
to exclusively Promote Products, in accordance with the terms and conditions of this Agreement,
Depomed agrees that if Depomed or any Affiliate thereof grants to any Affiliate or Third Party a
license, covenant not to sue, right of reference, right of supply, other intellectual property
right or other settlement (in any case, other than Patent Licenses and covenants not to sue and
other rights in connection with the grant of Patent Licenses for &#091;***&#093; commercialized in the
Territory prior to the Effective Date) related to the manufacture, use, offer for sale, sale,
importation, marketing or promotion of any Product, including any authorized generic version of any
Product covered by any NDA, then Depomed shall obtain Santarus&#146; consent (not to be unreasonably
withheld) in advance of the grant of any such license, covenant not to sue, right of reference,
right of supply, other intellectual property right or other settlement, and as part of such consent
the parties shall negotiate in good faith financial adjustments to this Agreement adequate to
compensate Santarus for any payments made by Santarus prior to such grant or other settlement
(including signing and any milestone payments) and any lost market share attributable to sales of
the product by or on behalf of such Third Party or Affiliate, taking into account the consideration
received by Depomed or its Affiliates for the grant of such rights or other settlement.
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

</TABLE>




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</DIV>




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<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;10.3 <U><B>Infringement</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;If either party shall learn of a claim or assertion that the manufacture, use or sale of a
Promoted Product in the Territory infringes or otherwise violates the intellectual property rights
of any Third Party or that any Third Party violates the intellectual property rights owned or
Controlled by (i)&nbsp;Depomed in a Promoted Product and the Depomed Trademarks in the Territory or (ii)
Santarus in the Santarus Trademarks, then the party becoming so informed shall promptly, but in all
events within fifteen (15)&nbsp;days thereof, notify the other party to this Agreement of the claim or
assertion. In the event Depomed receives a notice under Paragraph&nbsp;IV of the U.S. Federal Drug
Price Competition and Patent Term Restoration Act of 1984, as amended, also known as the
Hatch-Waxman Act, with respect to any Promoted Product, Depomed shall provide Santarus with written
notice of such Paragraph&nbsp;IV notice within two (2)&nbsp;business days (each, a &#147;<U>Paragraph&nbsp;IV
Notice</U>&#148;).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;If warranted in the opinion of Depomed, after consultation with the JCC, Depomed shall
take such legal action (&#147;<U>Enforcement Action</U>&#148;) as is advisable in Depomed&#146;s opinion to
restrain infringement of such Depomed patent rights related to any Product or the Depomed
Trademarks in the Territory. Santarus shall cooperate fully with, and as reasonably requested by,
Depomed in any Enforcement Action, and Depomed shall reimburse Santarus for its out-of-pocket
expenses incurred in providing such cooperation. Santarus may be represented by counsel of its own
selection at its own expense in any Enforcement Action. If (i)&nbsp;Depomed elects in writing not to
bring or defend an Enforcement Action with respect to any Product in the Territory, (ii)&nbsp;within
ninety (90)&nbsp;days following a written request by Santarus to do so (provided that in the case of a
Paragraph&nbsp;IV Notice, Depomed shall confirm in writing its election to bring such Enforcement Action
no later than twenty (20)&nbsp;days following receipt of the Paragraph&nbsp;IV Notice), or (iii)&nbsp;Depomed
fails to bring or defend an Enforcement Action or take other reasonable action to protect the
Depomed patent rights related to any Product or the Depomed Trademarks in the Territory from such
infringement, or to abate such infringement, then, in compliance with the BLS Manufacturing
Transfer Agreement or other in-license agreement with respect to applicable Product patent rights
licensed from a Third Party, if any, Santarus shall have the right, at its sole discretion, to
institute an Enforcement Action in its own name using counsel of its choice, at its own expense,
and with the right to control the course of such Enforcement Action (and Depomed shall provide all
reasonable assistance, other than financial, to Santarus for such Enforcement Action, at Santarus&#146;
expense, including joining such Enforcement Action if necessary to maintain the Enforcement Action,
and Depomed shall have the right to join and participate in the Enforcement Action whether or not
such joinder is requested by Santarus) (the &#147;<U>Santarus Step-In Rights</U>&#148;); provided, however,
that (i)&nbsp;the Santarus Step-In Rights shall not apply to the extent the Enforcement Action relates
to &#091;***&#093;; and (ii)&nbsp;Santarus shall obtain Depomed&#146;s consent (not to be unreasonably withheld) in
advance of the grant of any license, covenant not to sue, right of reference, right of supply,
other intellectual property right or other settlement in any Enforcement Action. Any recovery
received as a result of any Enforcement Action shall be used first to reimburse the parties for
their costs and expenses (including attorneys&#146; and professional fees) incurred in connection with
such Enforcement Action (and not previously reimbursed). Of any remaining amounts, the amount (if
any) which is required to be paid to BLS pursuant to the BLS Agreements or to any other licensors
of the applicable patent rights or Depomed Trademarks under the terms of the respective in-license
agreement, if any, shall then be paid to BLS or such
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->43<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">





<DIV align="left" style="font-size: 10pt; margin-top: 6pt">other licensor, if any, and any amounts remaining thereafter shall be shared seventy-five percent
(75%) to Santarus and twenty-five percent (25%) to Depomed.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;If warranted in the opinion of Santarus, Santarus shall take such legal action as is
advisable in Santarus&#146; opinion to restrain such infringement of the Santarus Trademarks. Depomed
shall cooperate fully with, and as requested by, Santarus in Santarus&#146; attempt to restrain such
infringement, and Santarus shall reimburse Depomed for its out-of-pocket expenses incurred in
providing such cooperation. Depomed may be represented by counsel of its own selection at its own
expense in any suit or proceeding brought to restrain such infringement, but Santarus shall have
the right to control the suit or proceeding.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE XI<BR>
INDEMNIFICATION; LIMITS ON LIABILITY</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;11.1 <U><B>Indemnification</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each party will defend, at its own expense, indemnify and hold harmless the other party and
its Affiliates, and their respective directors, officers, employees, agents, Sales Representatives
and other representatives, from and against any and all damages, liabilities, losses, costs, and
expenses, including reasonable attorneys&#146; fees, arising out of any Third Party claim, suit or
proceeding brought against the other party or its Affiliates, and their respective directors,
officers, employees, agents, Sales Representatives and other representatives, to the extent such
claim, suit, or proceeding is based upon a claim arising out of or relating to (i)&nbsp;any breach or
violation of, or failure to perform, any covenant or agreement made by such indemnifying party in
this Agreement, unless waived in writing by the indemnified party; (ii)&nbsp;any breach of the
representations or warranties made by such indemnifying party in this Agreement; or (iii)&nbsp;the
negligence or willful misconduct of the indemnifying party, except (under any of (i)&nbsp;or (ii)) to
the extent arising out of the breach, violation, failure, negligence or willful misconduct of the
indemnified party. In addition, Depomed will defend, at its own expense, indemnify and hold
harmless Santarus and its Affiliates, and their respective directors, officers, employees, agents,
Sales Representatives and other representatives, from and against any and all damages, liabilities,
losses, costs, and expenses, including reasonable attorneys&#146; fees, arising out of any Third Party
claim, suit or proceeding brought against Santarus or its Affiliates, or their respective
directors, officers, employees, agents, Sales Representatives and other representatives, to the
extent such claim, suit, or proceeding is based upon a claim arising out of or relating to (v)&nbsp;any
sale, use, Promotion or other commercialization of a Product by Depomed or any Third Party,
including King Pharmaceuticals, Inc., prior to the Promotion Commencement Date; (w)&nbsp;any actions of
the Depomed Sales Force, including any false or misleading representations to Professionals,
customers or others regarding Santarus or the Products; (x)&nbsp;any agreement between Depomed and BLS;
(y)&nbsp;any agreement between Depomed and Patheon; or (z)&nbsp;any claim made by any Person that the
manufacture, use or sale of the Products infringes or misappropriates the patent, trademark, or
other intellectual property rights of such Person, except with respect to any claim relating to the
Santarus Trademarks; or (z)&nbsp;any Product liability claim made by any person with respect to the
Product, except to the extent liability is based on a breach by Santarus of Section&nbsp;4.2. Each
party agrees that it shall promptly notify the other in writing of any such claim or action and
give the indemnifying party full information and assistance in connection therewith. The
indemnifying party shall have the sole right to control the defense and the sole right to settle or
compromise any
</DIV>

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</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">such claim or action, except that the prior written consent of the other party shall be
required in connection with any settlement or compromise which could (i)&nbsp;place any obligation on or
require any action of such other party; (ii)&nbsp;admit or imply any liability or wrongdoing of such
other party; or (iii)&nbsp;adversely affect the goodwill or public image of such other party.
Notwithstanding the foregoing, the indemnified party may participate therein through counsel of its
choice, but the cost of such counsel shall be borne solely by the indemnified party. The
provisions of this Section&nbsp;11.1 shall survive termination of this Agreement for the applicable
statute of limitations (except as to claims as to which a party has notified the other in writing
prior to the expiration of the applicable statute of limitations, in which event, the indemnifying
party&#146;s obligations under this Section&nbsp;11.1 shall survive with respect to any such claim until its
resolution pursuant to the terms of this Article&nbsp;XI).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;11.2 <U><B>Consequential Damages</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NEITHER SANTARUS NOR DEPOMED (WHICH FOR THE PURPOSES OF THIS SECTION 11.2 SHALL INCLUDE THEIR
RESPECTIVE AFFILIATES, DIRECTORS, OFFICERS, EMPLOYEES AND AGENTS) SHALL HAVE ANY LIABILITY TO THE
OTHER FOR ANY PUNITIVE DAMAGES, SPECIAL, INCIDENTAL, CONSEQUENTIAL OR INDIRECT DAMAGES, RELATING TO
OR ARISING FROM THIS AGREEMENT, EVEN IF SUCH DAMAGES MAY HAVE BEEN FORESEEABLE; PROVIDED THAT SUCH
LIMITATION SHALL NOT APPLY IN THE CASE OF EITHER PARTY&#146;S INDEMNIFICATION OBLIGATIONS UNDER SECTION
11.1 OR IN THE CASE OF FRAUD OR WILLFUL MISCONDUCT.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE XII<BR>
CONFIDENTIALITY AND PUBLICITY</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;12.1 <U><B>Proprietary Information</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to this Agreement, a party receiving Proprietary Information from the other, directly
or indirectly, will treat such Proprietary Information as confidential, will use such Proprietary
Information only for the purposes of this Agreement and will not disclose, and will take all
reasonable precautions to prevent the disclosure of, such Proprietary Information to (a)&nbsp;any of its
officers, directors, managers, equity holders, employees, agents, representatives, Affiliates or
consultants, except those who need to know such Proprietary Information and who are bound by a like
obligation of confidentiality or (b)&nbsp;to Third Parties.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;12.2 <U><B>Disclosures Required by Law</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In the event the recipient party is required under applicable Legal Requirements to disclose
Proprietary Information of the disclosing party to any Governmental Authority to obtain any
Regulatory Approval for the Products, is required to disclose Proprietary Information in connection
with bona fide legal process (including in connection with any bona fide dispute hereunder) or is
required to disclose Proprietary Information under the rules of the securities exchange upon which
its securities are traded, the recipient party may do so only if it limits disclosure to that
purpose after giving the disclosing party prompt written notice of any instance of such a
requirement in reasonable time for the disclosing party to attempt to object to or to limit
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->45<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">such disclosure. In the event of disclosures required under applicable Legal Requirements,
the recipient party shall cooperate with the disclosing party as reasonably requested thereby.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;12.3 <U><B>Publicity</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The parties have agreed upon the form and content of a joint press release to be issued by the
parties promptly following the execution of this Agreement. Once such press release or any other
written statement is approved for disclosure by both parties, either party may make subsequent
public disclosure of the contents of such statement without the further approval of the other
party. Any other publicity, news release, public comment or other public announcement, whether to
the press, to stockholders, or otherwise, relating to this Agreement, shall first be reviewed and
approved by both parties, except no such approval shall be required for such publicity, news
release, public comment or other public announcement which, in accordance with the advice of legal
counsel to the party making such disclosure, is required by law or for appropriate market
disclosure; <U>provided</U>, <U>however</U>, that each party shall be entitled to refer publicly
to the relationship of the parties reflected in this Agreement (i.e., Depomed as the developer of
the Products and Santarus as the promoter of the Products in the Territory) in a manner that is
consistent with the joint press release issued by the parties. For clarity, any party making any
announcement which is required by law will, unless prohibited by law, give the other party an
opportunity to review the form and content of such announcement and comment before it is made. The
parties shall work together to coordinate filings with governmental agencies, including the United
States Securities and Exchange Commission, as to the contents and existence of this Agreement as
the parties shall reasonably deem necessary or appropriate and each party shall provide the other
party an opportunity to comment on any proposed filings, including redactions thereto. The
provisions of this Article&nbsp;XII shall survive termination of this Agreement and shall remain in
effect until a date three years after the Term of this Agreement.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE XIII<BR>
RIGHT OF FIRST NEGOTIATION FOR CERTAIN COMBINATION PRODUCTS;<BR>
EXCLUSIVITY</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;13.1 <U><B>Right of First Negotiation</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Depomed shall notify Santarus in writing in the event that Depomed desires to divest itself of
its rights to the Product in the Territory (e.g., by asset sale or product license to a Third
Party) or to grant rights to a Third Party to develop or commercialize a pharmaceutical product
containing metformin and another generic active pharmaceutical ingredient (i.e., an active
pharmaceutical ingredient that is produced and distributed within the Territory without composition
of matter patent protection for the compound) in combination with Depomed&#146;s proprietary AcuForm
drug delivery technology incorporated within the Products (a &#147;<U>Combination Product</U>&#148;). If
Santarus notifies Depomed in writing within &#091;***&#093; days after receipt of such notice (the
&#147;<U>Evaluation Period</U>&#148;) that Santarus is not interested in obtaining all of Depomed&#146;s rights
in and to the Products or the applicable Combination Product (such rights, &#147;<U>Metformin Product
Rights</U>&#148;), or if Santarus fails to notify Depomed of Santarus&#146; interest in obtaining the
Metformin Product Rights, in either case prior to the expiration of the Evaluation Period, then
Depomed shall have no further obligation to Santarus under this Agreement with respect to the
applicable Metformin Product Rights. If Santarus is interested in obtaining the Metformin Product
Rights, it
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->46<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">





<DIV align="left" style="font-size: 10pt; margin-top: 6pt">shall so notify Depomed in writing prior to the expiration of the Evaluation Period, and upon
Depomed&#146;s receipt of such notice Santarus and Depomed shall promptly commence good-faith
negotiations, for a period of &#091;***&#093; days and such longer period as may be mutually agreed upon by
the parties in writing in the event the parties have made material progress in the negotiations
(the &#147;<U>Negotiation Period</U>&#148;), regarding the commercially reasonable terms of an agreement
pursuant to which Santarus shall obtain the Metformin Product Rights. If Depomed and Santarus fail
to enter into an agreement for the Metformin Product Rights prior to the expiration of the
Negotiation Period, then Depomed shall thereafter have the right to negotiate and enter into an
agreement with a Third Party granting the Metformin Product Rights to a Third Party; provided that,
for a period of &#091;***&#093;, any such agreement may not be on terms and conditions materially more
favorable to the Third Party than the terms and conditions last offered by Santarus prior to the
termination of discussions with Depomed. The provisions of this Section&nbsp;13.1 shall not apply to,
and Depomed shall have no obligation to Santarus under this Section&nbsp;13.1 in respect of, any
acquisition of Depomed by a Third Party, any merger or consolidation with or involving Depomed, any
acquisition by a Third Party of any material portion of the stock of Depomed, or any acquisition by
a Third Party of a material portion of the assets of Depomed in addition to the Products or any
Combination Product (&#147;<U>Merger Transaction</U>&#148;).
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;13.2 <U><B>Exclusivity</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;During the Term, Depomed shall not, directly or indirectly, develop, promote, market,
distribute, sell or offer for sale in the Territory any single agent metformin products for human
use, other than the Products in accordance with the terms of this Agreement. Depomed shall not
use, and shall not permit any Third Party to use, the Glumetza<SUP style="font-size: 85%; vertical-align: text-top">&#174;</SUP> trademark in the Territory with
respect to any product other than the Products.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE XIV<BR>
NOTICES</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;14.1 <U><B>Notices</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All notices required or permitted hereunder shall be given in writing and sent by facsimile
transmission (with a copy sent by first-class mail), or mailed postage prepaid by certified or
registered mail (return receipt requested), or sent by a nationally recognized express courier
service, or hand-delivered at the following address:
</DIV>
<DIV align="left" style="font-size: 10pt; margin-left: 9%; margin-top: 6pt">If to Depomed:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-left: 9%; margin-top: 6pt">Depomed, Inc.<BR>
1360 O&#146;Brien Drive<BR>
Menlo Park, California 94025<BR>
Attention: President<BR>
Fax No.: (650)&nbsp;462-9991
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->47<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">





<DIV align="left" style="font-size: 10pt; margin-left: 9%; margin-top: 6pt">With a copy to:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-left: 9%; margin-top: 6pt">Heller Ehrman LLP<BR>
275 Middlefield Road<BR>
Menlo Park, CA 94025<BR>
Attention: Julian Stern<BR>
Fax No: (650)&nbsp;324-0638
</DIV>

<DIV align="left" style="font-size: 10pt; margin-left: 9%; margin-top: 6pt">If to Santarus:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-left: 9%; margin-top: 6pt">Santarus, Inc.<BR>
3721 Valley Centre Drive<BR>
Suite&nbsp;400<BR>
San Diego, California 92130<BR>
Attn: Legal Affairs Department<BR>
Facsimile: (858)&nbsp;314-5702
</DIV>

<DIV align="left" style="font-size: 10pt; margin-left: 9%; margin-top: 6pt">With a copy to (which shall not constitute notice<BR>
hereunder):
</DIV>

<DIV align="left" style="font-size: 10pt; margin-left: 9%; margin-top: 6pt">Latham &#038; Watkins LLP<BR>
12636 High Bluff Drive, Suite&nbsp;400<BR>
San Diego, California 92130<BR>
Attention: Faye H. Russell<BR>
Fax No: (858)&nbsp;523-5450
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">All notices shall be deemed made upon receipt by the addressee as evidenced by the applicable
written receipt.
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE XV<BR>
INSURANCE</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;15.1 <U><B>Insurance</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;During the Term and for a period of two (2)&nbsp;years after any expiration or termination of
this Agreement, each party shall maintain (i)&nbsp;a commercial general liability insurance policy or
policies with minimum limits of $&#091;***&#093; per occurrence and $&#091;***&#093; in the aggregate on an annual
basis and (ii)&nbsp;a product liability insurance policy or policies with minimum limits of $&#091;***&#093; per
occurrence and $&#091;***&#093; in the aggregate on an annual basis.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Upon request, each party shall provide certificates of insurance to the other evidencing
the coverage specified herein. Neither party&#146;s liability to the other is in any way limited to the
extent of its insurance coverage.
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->48<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">






<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ARTICLE XVI<BR>
MISCELLANEOUS</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.1 <U><B>Headings</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The titles, headings or captions and paragraphs in this Agreement are for convenience only and
do not define, limit, extend, explain or describe the scope or extent of this Agreement or any of
its terms or conditions and therefore shall not be considered in the interpretation, construction
or application of this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.2 <U><B>Severability</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In the event that any of the provisions or a portion of any provision of this Agreement is
held to be invalid, illegal, or unenforceable by a court of competent jurisdiction or a
governmental authority, such provision or portion of provision will be construed and enforced as if
it had been narrowly drawn so as not to be invalid, illegal, or unenforceable, and the validity,
legality, and enforceability of the enforceable portion of any such provision and the remaining
provisions will not be adversely affected thereby.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.3 <U><B>Entire Agreement</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Agreement, together with the schedules and exhibits hereto and the Confidentiality
Agreement, all of which are incorporated by reference, contains all of the terms agreed to by the
parties regarding the subject matter hereof and supersedes any prior agreements, understandings, or
arrangements between them, whether oral or in writing.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.4 <U><B>Amendments</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Agreement may not be amended, modified, altered, or supplemented except by means of a
written agreement or other instrument executed by both of the parties hereto. No course of conduct
or dealing between the parties will act as a modification or waiver of any provisions of this
Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.5 <U><B>Counterparts</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Agreement may be executed in any number of counterparts, each of which will be deemed an
original as against the party whose signature appears thereon, but all of which taken together will
constitute but one and the same instrument.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.6 <U><B>Waiver</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The failure of either party to enforce or to exercise, at any time or for any period of time,
any term of or any right arising pursuant to this Agreement does not constitute, and will not be
construed as, a waiver of such term or right, and will in no way affect that party&#146;s right later to
enforce or exercise such term or right.
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->49<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.7 <B><u>Force Majeure</u></B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;In the event of any failure or delay in the performance by a party of any provision of
this Agreement due to acts beyond the reasonable control of such party (such as, for example, fire,
explosion, strike or other difficulty with workmen, shortage of transportation equipment, accident,
act of God, declared or undeclared wars, acts of terrorism, or compliance with or other action
taken to carry out the intent or purpose of any law or regulation, but not any failure of such
party to perform under a Third Party agreement) (a &#147;<U>Force Majeure Event</U>&#148;), then such party
shall have such additional time to perform as shall be reasonably necessary under the
circumstances. In the event of such failure or delay, the affected party will use its diligent
efforts, consistent with sound business judgment and to the extent permitted by law, to correct
such failure or delay as expeditiously as possible. In the event that a party is unable to perform
by a reason described in this Section&nbsp;16.7, its obligation to perform under the affected provision
of this Agreement shall be suspended during such time of nonperformance.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Neither party shall be liable hereunder to the other party nor shall be in breach for
failure to perform its obligations caused by a Force Majeure Event. In the case of any such event,
the affected party shall promptly, but in no event later than ten (10)&nbsp;days of its occurrence,
notify the other party stating the nature of the condition, its anticipated duration and any action
being taken to avoid or minimize its effect. Furthermore, the affected party shall keep the other
party informed of the efforts to resume performance. After sixty (60)&nbsp;days of such inability to
perform, the parties agree to meet and in good faith discuss how to proceed. In the event that the
affected party is prevented from performing its obligations pursuant to this Section&nbsp;16.7 for a
period of six (6)&nbsp;months, the other party shall have the right to terminate this Agreement pursuant
to the provisions of Sections&nbsp;8.4(b).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.8 <U><B>Successors and Assigns</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Subject to Section&nbsp;16.9, this Agreement shall be binding upon and shall inure to the benefit
of the parties hereto and their respective successors and assigns permitted under this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.9 <U><B>Assignment</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Agreement and the rights granted herein shall not be assignable (or otherwise
transferred) by either party hereto without the prior written consent of the other party. Any
attempted assignment without consent shall be void. Notwithstanding the foregoing, a party may
transfer, assign or delegate its rights and obligations under this Agreement without consent to (a)
an Affiliate reasonably capable of performing such party&#146;s obligations under this Agreement or (b)
a successor to all or substantially all of its business or assets of the assigning party to which
this Agreement relates, whether by sale, merger, consolidation, acquisition, transfer, operation of
law or otherwise or (c)&nbsp;in the case of either party, to one or more financial institutions
providing financing to such party pursuant to the terms of a security agreement relating to such
financing. In connection with any assignment, or Subcontracting pursuant to which a Third Party
Sales Representative is engaged to Promote the Products, of this Agreement or any of the rights
granted herein pursuant to this Section&nbsp;16.9, the assignor, or party Subcontracting to another,
shall ensure that the assignee, or Subcontractor, represents and warrants the matters set forth in
Sections&nbsp;9.1(j) and (k) (in substantially the same form as set forth in Sections&nbsp;9.1(j) and (k)),
where Depomed (or
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->50<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">one of its successors or assigns) is the assignor or Subcontracting party, or Sections&nbsp;9.2(h)
and (i) (in substantially the same form as set forth in Sections&nbsp;9.2(h) and (i)), where Santarus
(or one of its successors or assigns) is the assignor or Subcontracting party. In connection with
any Subcontracting pursuant to which a Third Party will manufacture the Products, the party
Subcontracting to another shall use its commercially reasonable efforts to cause the Subcontractor
to represent and warrant the matters set forth in Sections&nbsp;9.1(j) and (k) (in substantially the
same form as set forth in Sections&nbsp;9.1(j) and (k)). Neither party shall knowingly engage any Third
Party appearing on the FDA&#146;s debarment list or the list of excluded individuals/entities of the
Office of Inspector General of the Department of Health and Human Services to perform, or assist
such party in the performance of, its obligations under this Agreement, and each party shall review
each such list prior to engaging any such Third Party.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.10 <U><B>Construction</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The parties acknowledge and agree that: (a)&nbsp;each party and its representatives have reviewed
and negotiated the terms and provisions of this Agreement and have contributed to its revision; and
(b)&nbsp;the terms and provisions of this Agreement will be construed fairly as to each party hereto and
not in favor of or against either party regardless of which party was generally responsible for the
preparation or drafting of this Agreement. Unless the context of this Agreement otherwise
requires: (i)&nbsp;words of any gender include each other gender; (ii)&nbsp;words using the singular or
plural number also include the plural or singular number, respectively; (iii)&nbsp;the terms &#147;hereof,&#148;
&#147;herein,&#148; &#147;hereby,&#148; and derivative or similar words refer to this entire Agreement; (iv)&nbsp;the terms
&#147;Article,&#148; &#147;Section,&#148; &#147;Exhibit,&#148; &#147;Schedule,&#148; or &#147;clause&#148; refer to the specified Article, Section,
Exhibit, Schedule, or clause of this Agreement; (v) &#147;or&#148; is disjunctive but not necessarily
exclusive; and (vi)&nbsp;the term &#147;including&#148; or &#147;includes&#148; means &#147;including without limitation&#148; or
&#147;includes without limitation.&#148; Whenever this Agreement refers to a number of days, such number
shall refer to calendar days unless business days are specified.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.11 <U><B>Governing Law</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Agreement will be construed under and in accordance with, and governed in all respects
by, the laws of the State of California, without regard to its conflicts of law principles.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.12 <U><B>Equitable Relief</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each party acknowledges that a breach by it of the provisions of this Agreement may not
reasonably or adequately be compensated in damages in an action at law and that such a breach may
cause the other party irreparable injury and damage. By reason thereof, each party agrees that the
other party is entitled to seek, in addition to any other remedies it may have under this Agreement
or otherwise, preliminary and permanent injunctive and other equitable relief to prevent or curtail
any breach of this Agreement by the other party; provided, however, that no specification in this
Agreement of a specific legal or equitable remedy will be construed as a waiver or prohibition
against the pursuing of other legal or equitable remedies in the event of such a breach. Each party
agrees that the existence of any claim, demand, or cause of action of it against the other party,
whether predicated upon this Agreement, or otherwise, will not constitute a defense to the
enforcement by the other party, or its successors or assigns, of the covenants contained in this
Agreement.
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->51<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;16.13 <B><u>Relationship Between Parties</u></B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The parties hereto are acting and performing as independent contractors, and nothing in this
Agreement creates the relationship of partnership, joint venture, sales agency, or principal and
agent. Neither party is the agent of the other, and neither party may hold itself out as such to
any other party. All financial obligations associated with each party&#146;s business will be the sole
responsibility of such party.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt">&#091;Signature page follows&#093;
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->52<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">IN WITNESS WHEREOF, the parties have caused this Agreement to be executed in duplicate on the day
and year first above written.
</DIV>


<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">DEPOMED, INC.<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD colspan="3" style="border-bottom: 1px solid #000000" align="left">/s/ Carl A. Pelzel
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD colspan="3" align="left">By: Carl A. Pelzel&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD colspan="3" align="left">Its: President and CEO&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">SANTARUS, INC.<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD colspan="3" style="border-bottom: 1px solid #000000" align="left">/s/ Gerald T. Proehl
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD colspan="3" align="left">By: Gerald T. Proehl&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD colspan="3" align="left">Its: President and CEO&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>

</TABLE>

<P align="center" style="font-size: 10pt"><!-- Folio -->53<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>

</TABLE>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SCHEDULES</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Schedule&nbsp;1.37 &#151; Depomed Trademarks
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Schedule&nbsp;1.55 &#151; Launch Plan
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Schedule&nbsp;1.93 &#151; Santarus Trademarks
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Schedule&nbsp;4.5(h) &#151; Depomed Promotional Activities
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Schedule&nbsp;1.37</B>
</DIV>


<DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>Depomed Trademarks</B>

</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="60%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="37%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Mark</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Serial/Registration Numbers</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">GLUMETZA<SUP style="font-size: 85%; vertical-align: text-top">1</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Reg. No.&nbsp;3366577</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">DEPOMED
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Reg. No.&nbsp;2112593</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">DEPOMED (word and design mark)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Ser. No.&nbsp;78781903</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">ACUFORM
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Ser. No.&nbsp;78781863</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">G (stylized design mark)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Ser. No. 78931764</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">1</SUP></TD>
    <TD>&nbsp;</TD>
    <TD>Owned by BLS, and licensed in the United States to
Depomed for the purpose of promoting the Products.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">






<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Schedule&nbsp;1.55</B>
</DIV>


<DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>Launch Plan</B>

</DIV>

<DIV align="Center" style="font-size: 10pt; margin-top: 6pt">&#091;***&#093;

</DIV>

<DIV align="Center" style="font-size: 10pt; margin-top: 6pt">&#091;Schedule redacted in its entirety (10 pages)&#093;

</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">






<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Schedule&nbsp;1.93</B>
</DIV>


<DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>Santarus Trademarks</B>

</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="60%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="37%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Mark</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Serial/Registration Numbers</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">SANTARUS
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Reg. No.&nbsp;2,711,984</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">SANTARUS logo
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Reg. No.&nbsp;2,896,926</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Triangle logo
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Reg. No.&nbsp;2,899,097</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Schedule&nbsp;4.5(h)</B>
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<DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>Depomed Promotional Activities</B>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&#091;***&#093;
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    <TD>Certain information on this page has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.</TD>
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