PHARMACOPEIA INC
EX-10.1
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<DESCRIPTION>EX-10.1
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<p align="right" style="margin:0in 0in .0001pt;text-align:right;text-autospace:none;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Exhibit&nbsp;10.1</font></b></p>

<p align="right" style="margin:0in 0in .0001pt;text-align:right;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">SECOND AMENDED AND RESTATED</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">SEVERANCE AGREEMENT</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">This <b>SECOND AMENDED AND RESTATED SEVERANCE AGREEMENT</b>
(the &#147;<u>Agreement</u>&#148;) is made
and entered into as of the 18th day of September, 2008 by and between
PHARMACOPEIA, INC., a Delaware corporation (hereinafter, the &#147;<u>Company</u>&#148;), and Rene Belder, M.D.,
an individual (hereinafter, &#147;<u>Employee</u>&#148;).</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><b><u><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">RECITALS</font></u></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">WHEREAS,</font></b> Employee is presently employed by the
Company the capacity of Senior Vice President, Clinical and Regulatory Affairs
of the Company, pursuant to a Letter Agreement between the Company and
Employee, dated November&nbsp;2, 2006 (the &#147;Letter Agreement&#148;).</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">WHEREAS,</font></b> the Company and Employee previously entered
into an Amended and Restated Severance Agreement, dated as of December&nbsp;18,
2007 (the &#147;Existing Severance Agreement&#148;), pursuant to which Employee is
entitled to certain payments and benefits in the event of a covered termination
of Employee&#146;s employment with the Company.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">WHEREAS,</font></b> the Company and Employee wish to amend and
restate the Existing Severance Agreement to reflect the promotion of Employee
to the position of Senior Vice President, Clinical and Regulatory Affairs of
the Company from Vice President, Clinical and Regulatory Affairs of the
Company.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">NOW,
THEREFORE,</font></b> in
consideration of their mutual promises and intending to be legally bound, the
parties agree as follows:</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">1.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">TERMINATION AND EFFECT OF
TERMINATION</u></b><b>.</b>&#160; Employee&#146;s employment hereunder is AT WILL
and may be terminated at any time by the Company for any reason.&#160; In the event of termination of Employee&#146;s
employment, the Company shall have no liability to Employee for compensation or
benefits except as specified in this Section&nbsp;1 or as required by the
Company&#146;s benefits policy.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(a)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Termination By The Company
For Cause</u></b><b>.</b>&#160; Employee&#146;s employment may be terminated by
the Company for Cause (as defined
below)<b>  </b>at any time upon
delivery of written notice to Employee.&#160;
Upon such a termination, the Company shall have no obligation to
Employee other than the payment of all accrued, but unpaid, base salary and any
unpaid expenses or expense reimbursements prior to the effective date of such
termination.&#160; For purposes of this
Agreement, &#147;<u>Cause</u>&#148; means
the occurrence of any one or more of the following events or conditions:</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(i)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>any gross failure on the part of Employee
(other than by reason of disability as provided in
Section&nbsp;1(e)&nbsp;below) to faithfully and professionally carry out
Employee&#146;s duties or to comply with any other material provision of this
Agreement, which failure continues for thirty (30) days after written notice
detailing such failure is delivered by the Company; provided, that the Company
shall not be required to provide such notice in the event that such failure
(A)&nbsp;is not susceptible to remedy or (B)&nbsp;relates to the same type of
acts or omissions as to which notice has been given on a prior occasion;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(ii)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>Employee&#146;s dishonesty (which shall include
without limitation any misuse or misappropriation of the Company&#146;s assets), or
other willful misconduct (including without limitation, any conduct on the part
of Employee intended to or likely to injure the business of the Company);</p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">1</font></p>

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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(iii)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>Employee&#146;s conviction of any felony or of any
other crime involving moral turpitude, whether or not relating to Employee&#146;s
employment;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(iv)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>Employee&#146;s insobriety or use of drugs,
chemicals or controlled substances either (A)&nbsp;in the course of performing
Employee&#146;s duties and responsibilities under this Agreement, or
(B)&nbsp;otherwise affecting the ability of Employee to perform the same;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(v)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>Employee&#146;s failure to comply with a lawful
written direction of the Company; or</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(vi)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>any wanton or willful dereliction of duties
by Employee.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(b)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Involuntary Termination By
The Company Without Cause</u></b><b>.</b>&#160; The Company may involuntarily terminate
Employee&#146;s employment under this Agreement at any time without Cause upon
delivery of written notice to Employee.&#160;
Subject to the provisions of Section&nbsp;1(g)&nbsp;hereof (concerning a
termination in connection with a Change in Control (as defined in Section&nbsp;1(g)), if Employee&#146;s
employment is terminated involuntarily by the Company without Cause pursuant to
this Section&nbsp;1(b), the Company shall:</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(i)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>pay Employee all compensation and benefits
accrued, but unpaid, up to the effective date of termination of Employee&#146;s
employment;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(ii)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>pay Employee, within thirty (30) days after
the effective date of termination of Employee&#146;s employment, a lump sum amount
equal to nine (9)&nbsp;months of Employee&#146;s base salary in effect as of the
effective date of termination of Employee&#146;s employment;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(iii)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>pay Employee, within thirty (30) days after
the effective date of termination of Employee&#146;s employment, a lump sum pro rata
portion of Employee&#146;s target incentive bonus for the calendar year in which
Employee&#146;s employment is terminated as provided in this Section&nbsp;1(b), such
portion to be based on the number of full months for which Employee was
employed during the year of termination;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(iv)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>maintain Employee&#146;s group medical coverage
until the earlier of (A)&nbsp;the end of a period of nine (9)&nbsp;months
following the effective date of such termination, or (B) until such time as
comparable medical coverage is obtained by Employee; and</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(v)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>allow all vested options or other incentive
securities to be exercised pursuant to the terms of the option agreement or
other agreements under which such options or other incentive securities were
granted.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(c)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Termination By Employee For
Good Reason</u></b><b>.</b></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(i)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><b><u style="font-weight:bold;">Benefits</u></b><b>.</b>&#160;
Employee may terminate Employee&#146;s employment under this Agreement for
Good Reason (as defined below) upon the provision of advance written notice to
the Company specifying in reasonable detail the events or conditions upon which
Employee is basing such termination.&#160;
Employee must give such notice within ninety (90) days after the event
that gives rise to Good Reason.&#160; The
Company will be given the opportunity, but shall have no obligation, to cure
such events or conditions within thirty (30) days after the provision by
Employee of such notice.&#160; If the Company
elects in a written notice to Employee not to cure such events or conditions or
otherwise fails to so cure such events or conditions within such thirty (30)
day period, Employee may terminate his employment with the Company for Good
Reason pursuant to this Section&nbsp;1(c)&nbsp;within thirty (30) days after
the expiration of the &#147;cure&#148; period.&#160; In
the event of such termination, the Company shall:</p>

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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2</font></p>

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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(A)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>pay Employee all compensation and benefits
accrued, but unpaid, up to the effective date of termination of Employee&#146;s
employment;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(B)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>pay Employee, within thirty (30) days after
the effective date of termination of Employee&#146;s employment, a lump sum amount
equal to nine (9)&nbsp;months of Employee&#146;s base salary in effect as of the
effective date of termination of Employee&#146;s employment;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(C)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>pay Employee, within thirty (30) days after
the effective date of termination of Employee&#146;s employment, a lump sum pro rata
portion of Employee&#146;s target incentive bonus for the calendar year in which
Employee&#146;s employment is terminated as provided in this Section&nbsp;1(c), such
portion to be based on the number of full months for which Employee was
employed during the year of termination;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(D)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>maintain Employee&#146;s group medical coverage
until the earlier of (A)&nbsp;the end of a period of nine (9)&nbsp;months
following the effective date of such termination, or (B)&nbsp;until such time
as comparable medical coverage is obtained by Employee; and</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(E)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>allow all vested options or other incentive
securities to be exercised pursuant to the terms of the option agreement or
other agreements under which such options or other incentive securities were
granted.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(ii)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><b><u style="font-weight:bold;">Definition of &#147;Good Reason</u></b><b>.&#148;</b> For purposes of this Agreement, &#147;<u>Good Reason</u>&#148; means any one or more
of the following events or conditions:</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(A)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>any action or inaction that constitutes a
material breach by the Company of the terms of this Agreement or the Letter
Agreement;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(B)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>any material change in the geographic
location at which Employee must perform services for the Company, which, for
purposes of this Agreement, means a requirement that Employee commute more than
fifty (50) miles from the offices of the Company at which he was principally
employed on the date of this Agreement;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(C)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>any material diminution of the authority,
duties or responsibilities of Employee, including without limitation a material
diminution in Employee&#146;s position as Vice President, Clinical and Regulatory
Affairs; or</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(D)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>any material reduction in Employee&#146;s base
salary (other than such a reduction applicable generally to substantially all
employees of the Company), which, for purposes of this Agreement, means a
reduction of more than twenty percent (20%) in Employee&#146;s annual base salary as
in effect on the date of this Agreement or as the same may be increased from time
to time after such date.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(d)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Termination By Employee
Without Good Reason (Voluntary Resignation)</u></b><b>.</b>&#160;
Employee may voluntarily resign Employee&#146;s position and terminate
Employee&#146;s employment under this Agreement without Good Reason at any
time.&#160; Upon such a termination, the
Company shall have no obligation to pay compensation and provide benefits to
Employee other than the payment of all accrued and unpaid base salary and any
other unpaid expenses or expense reimbursements prior to the effective date of
such termination.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(e)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Disability</u></b><b>.</b>&#160; If
Employee becomes disabled for more than one hundred eighty (180) days in any
twelve (12) month period, the Company shall have the right to terminate
Employee&#146;s employment without further liability upon written notice to Employee.&#160; Without limiting the generality of </p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3</font></p>

<div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>

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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">the foregoing, Employee
shall be deemed disabled for purposes of this Agreement either (i)&nbsp;if
Employee is deemed disabled for purposes of any long-term disability insurance
policy paid for by the Company and at the time in effect, or (ii)&nbsp;if in
the exercise of the Company&#146;s reasonable judgment, due to accident, mental or
physical illness, or any other reason, Employee cannot perform Employee&#146;s
duties.&#160; In the event the Company shall
terminate Employee due to disability, as described above, Employee shall be
entitled to receive only those benefits provided under the Company&#146;s Long Term
Disability Plan, and Employee&#146;s stock options and other incentive compensation
grants will be treated under the applicable Disability section of the 2004
Stock Incentive Plan (as amended, the &#147;<u>2004 Plan</u>&#148;) or any other stock
option or incentive compensation plan of the Company under which they were
granted.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(f)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Death</u></b><b>.</b>&#160; In
the event of the death of Employee, this Agreement shall automatically
terminate and any obligation to continue to pay compensation and benefits shall
cease as of the date of Employee&#146;s death, except for the payment of all
accrued, but unpaid, base salary and any other unpaid expenses or expense
reimbursements prior to the date of death.&#160;
In the event of Employee&#146;s death, Employee&#146;s stock options and other
incentive compensation grants shall be treated under the applicable Death
section of the 2004 Plan or any other stock option or incentive compensation
plan of the Company under which they were granted.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(g)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Change In Control
Termination</u></b><b>.</b></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(i)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><b><u style="font-weight:bold;">Benefits</u></b><b>.</b>&#160; In
the event Employee&#146;s employment under this Agreement is terminated by the
Company involuntarily without Cause or Employee terminates Employee&#146;s employment
with the Company for Good Reason (as defined in Section&nbsp;1(c)&nbsp;above),
in either case at any time during the period commencing two (2)&nbsp;months
before and ending twelve (12) months after the occurrence of a Change in
Control, the Company shall:</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(A)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>pay Employee all compensation and benefits
accrued, but unpaid, up to the effective date of termination of Employee&#146;s
employment;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(B)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>pay Employee, within thirty (30) days after
the effective date of termination of Employee&#146;s employment, a lump sum amount
equal to twelve (12) months of Employee&#146;s base salary in effect as of the
effective date of Employee&#146;s termination of employment;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(C)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; p</font>ay Employee, within thirty (30) days after
the effective date of termination of Employee&#146;s employment, a lump sum amount
equal to <u>one hundred</u>
percent (<u>100</u>%) of
Employee&#146;s target incentive bonus;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(D)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>maintain Employee&#146;s group medical coverage
until the earlier of (A) the end of a period of twelve (12)<b>  </b>months following the effective date of
termination<b>, </b>or (B)&nbsp;such time
as comparable medical coverage is obtained by Employee.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Anything contained in this
Section&nbsp;to the contrary notwithstanding, Employee shall not be entitled to
any of the benefits set forth in this Section&nbsp;1(g)(i)&nbsp;if Employee
either resigns and terminates such employment voluntarily (other than for Good
Reason, as described above) or is terminated by the Company for Cause.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">For purposes of
Section&nbsp;1(g)&nbsp;hereof, the term &#147;<u>Company</u>&#148; shall include any Acquiring Company (as defined below),
and all obligations of the Company under such Section&nbsp;shall be assumed by
any Acquiring Company.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(ii)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><b><u style="font-weight:bold;">Stock Options</u></b><b>.</b>&#160; In
the event Employee&#146;s employment under this Agreement is terminated by the
Company involuntarily without Cause or Employee terminates his employment with
the Company for Good Reason, in either case at any time during the period </p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4</font></p>

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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">commencing two
(2)&nbsp;months before and ending twelve (12) months after the occurrence of a
Change in Control:</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(A)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>notwithstanding anything to the contrary
contained in the 2004 Plan or any other stock option or incentive compensation
plan of the Company, any unvested stock options or other incentive securities
which were granted to Employee during the term of this Agreement under the 2004
Plan or any such other stock option or incentive compensation plan shall
immediately vest on the date of such termination of Employee&#146;s employment, the
expiration date of the exercise period for such options or other securities
shall be the earlier of (1)&nbsp;one (1)&nbsp;year following the date of
termination, or (2)&nbsp;the expiration of the term of the option, and the
Company shall take all actions necessary or advisable to give effect to this
Section&nbsp;1(g)(ii)(A); and</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(B)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>all vested options or other incentive
securities held by Employee which were issued pursuant to the 2004 Plan or any
such other plan shall be exercisable pursuant to the terms of the stock option
agreement or other agreement(s)&nbsp;under which the options or other incentive
securities were granted, and the Company shall take all actions necessary or
advisable to give effect to this Section&nbsp;1(g)(ii)(B).</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:2.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Anything contained in this
Section&nbsp;to the contrary notwithstanding, Employee shall not be entitled to
any of the benefits set forth in this Section&nbsp;1(g)(ii)&nbsp;if Employee
either resigns and terminates such employment voluntarily (other than for Good
Reason, as described above) or is terminated by the Company for Cause.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(iii)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><b><u style="font-weight:bold;">Definition &#147;Change in
Control</u></b><b>.&#148;</b>&#160; The definition of &#147;<u>Change in Control</u>&#148; set forth in the 2004 Plan is incorporated,
and made a part hereof, by reference.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(iv)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><b><u style="font-weight:bold;">Definition Of &#147;Acquiring
Company</u></b><b>.&#148;</b>&#160; For purposes of Section&nbsp;1(g)&nbsp;of
this Agreement, an &#147;<u>Acquiring
Company</u>&#148; shall mean the resulting or surviving corporation, or the
company issuing cash or securities (or its ultimate parent company), in a
merger, sale, asset purchase, or assignment of all or substantially all of the
Company&#146;s assets, consolidation or share exchange involving the Company, or the
successor corporation to the Company (whether in any such transaction or
otherwise).</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">2.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">GENERAL RELEASE</u></b><b>.</b>&#160;
Notwithstanding anything in this Agreement to the contrary, no payments
shall be made or benefits provided by the Company under Section&nbsp;1 unless
Employee executes and does not revoke a general release in favor of the Company
and its affiliates, and its and their respective officers, employees and
directors.&#160; A form of general release is
attached hereto as <u>Exhibit&nbsp;A</u>.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">3.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">SECTION&nbsp;409A</u></b><b>.</b>&#160; This
Agreement is intended to meet the requirements of the short-term deferral
exemption under section 409A of the Internal Revenue Code of 1986, as amended
(the &#147;Code&#148;).&#160; However, if required by
section 409A and if Employee is a &#147;specified employee&#148; of a publicly traded
corporation under section 409A of the Code, payment of any amount under this
Agreement shall be delayed for a period of six (6)&nbsp;months after separation
from service, as required by section 409A of the Code.&#160; The accumulated postponed amount shall be
paid in a lump sum payment within ten (10)&nbsp;days after the end of the six
(6)-month period.&#160; If Employee dies
during the postponement period prior to payment of the postponed amount, the
amounts withheld on account of section 409A shall be paid to the personal
representative of Employee&#146;s estate within sixty (60) days after the date of
Employee&#146;s death.&#160; The determination of
&#147;specified employees&#148; shall be made by the Compensation Committee of the Board
of Directors of the Company in accordance with section 409A of the Code and the
regulations issued thereunder.</p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">5</font></p>

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<div style="font-family:Times New Roman;">

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">4.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">NON-COMPETITION;
NON-SOLICITATION</u></b>.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(a)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Restrictions</u></b><b>.</b>&#160; Employee
shall not, during the course of Employee&#146;s employment with the Company or for a
period of twelve (12) months thereafter, directly or indirectly:</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(i)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>be employed by, engaged in or participate in
the ownership, management, operation or control of, or act in any advisory or
other capacity (including as an individual, principal, agent employee, consultant
or otherwise) for, any Competing Entity which conducts its business within the
Territory (as the terms Competing Entity and Territory are hereinafter
defined); provided, however, that notwithstanding any of the foregoing,
Employee may make solely passive investments in any Competing Entity the common
stock of which is &#147;publicly -held&#148; and of which Employee shall not own or
control, directly or indirectly, in the aggregate securities which constitute
5% or more of the voting power of such Competing Entity;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(ii)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>solicit or divert any business or any
customer or known prospective customer from the Company or assist any person or
entity in doing so or attempting to do so;</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(iii)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>cause or seek to cause any person or entity
to refrain from dealing or doing business with the Company or assist any person
or entity in doing so; or</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(iv)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>solicit for employment, or advise or
recommend to any other person or entity that he, she or it employ or solicit
for employment or retention as an employee or consultant, any person who is an
employee of, or exclusive consultant to, the Company.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(b)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Effect On The Company&#146;s
Obligations</u></b><b>.</b>&#160; The Company&#146;s obligation to make payments and
provide the other benefits pursuant to Section&nbsp;1 above shall terminate in
the event that, and at such time as, Employee is in breach of Employee&#146;s
obligations set forth in Section&nbsp;4(a)&nbsp;above.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(c)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Definitions</u></b><b>.</b>&#160; For
purposes of this Section&nbsp;4:</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(i)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>&#147;<u>Competing
Entity</u>&#148; means any entity which is presently or hereafter principally
engaged in any business of the type or character engaged in or proposed to be
engaged in by the Company from time to time during Employee&#146;s term of
employment under this Agreement, including without limitation, any business
engaged in the discovery and development of human therapeutic products for any
of the same targets and for indications as products the Company had in
development or was marketing at any time during Employee&#146;s term of employment
under this Agreement.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(ii)</font><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>&#147;<u>Territory</u>&#148;
means North America, Europe and Japan.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Notwithstanding anything in
the above to the contrary, Employee may engage in the activities set forth in
Section&nbsp;4(a)&nbsp;hereof with the prior written consent of the Company,
which consent shall not be unreasonably withheld.&#160; Further, in determining whether a specific
activity by Employee for a Competing Entity shall be permitted, the Company
will consider, among other things, the nature and scope of (i)&nbsp;the duties
to be performed by Employee and (ii) the business activities of the Competing
Entity at the time of Employee&#146;s proposed engagement by such entity.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(d)</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">Acknowledgement</u></b><b>.</b>&#160;
Employee acknowledges and agrees that the covenants set forth in this
Section&nbsp;4 are reasonable and necessary in all respects for the protection
of the Company&#146;s legitimate business interests (including, without limitation,
the Company&#146;s confidential, proprietary information and trade secrets and
client good-will, which represents a significant portion of the Company&#146;s net
worth and in which the Company has a property interest).&#160; Employee acknowledges and </p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">6</font></p>

<div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>

</div>
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<br clear="all" style="page-break-before:always;">


<div style="font-family:Times New Roman;">

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">agrees that, in the event
that Employee breaches any of the covenants set forth in this Section&nbsp;4, the
Company shall be irreparably harmed and shall not have an adequate remedy at
law; and, therefore, in the event of such a breach, the Company shall be
entitled to injunctive relief, in addition to (and not exclusive of) any other
remedies (including monetary damages) to which the Company may be entitled
under law.&#160; If any covenant set forth in
this Section&nbsp;4 is deemed invalid or unenforceable for any reason, it is
the parties&#146; intention that such covenants be equitably reformed or modified to
the extent necessary (and only to such extent) to render it valid and
enforceable in all respects. &#160;In the
event that the time period and geographic scope referenced above is deemed
unreasonable, overbroad, or otherwise invalid, it is the parties&#146; intention
that the enforcing court shall reduce or modify the time period and/or
geographic scope to the extent necessary (and only to such extent) to render
such covenants reasonable, valid and enforceable in all respects.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">5.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">ARBITRATION</u></b><b>.</b>&#160; Any
and all disputes between the parties (except actions to enforce the provisions
of Section&nbsp;4 of this Agreement) arising under or relating to this
Agreement or any other dispute arising between the parties, including claims
arising under any employment discrimination laws, may be adjudicated and
resolved exclusively through binding arbitration before the American Arbitration
Association pursuant to the American Arbitration Association&#146;s then-in-effect
National Rules&nbsp;for the Resolution of Employment Disputes (hereinafter, &#147;<u>Rules</u>&#148;).&#160; The initiation and conduct of any arbitration
hereunder shall be in accordance with the Rules&nbsp;and, unless expressly
required by law, each side shall bear its own costs and counsel fees in such
arbitration.&#160; Any arbitration hereunder
shall be conducted in Princeton, New Jersey or at such other location as
mutually agreed by the parties.&#160; Any
arbitration award shall be final and binding on the parties.&#160; The arbitrator shall have no authority to
depart from, modify, or add to the written terms of this Agreement.&#160; The arbitration provisions of this
Section&nbsp;5 shall be interpreted according to, and governed by, the Federal
Arbitration Act, 9 U.S.C. &#167; 1 <u>et
seq.</u>, and any action pursuant to such Act to enforce any rights
hereunder shall be brought exclusively in any United States District Court in
the State of New Jersey.&#160; The parties
consent to the jurisdiction of (and the laying of venue in) any such court.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">6.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">NOTICES</u></b><b>.&#160; </b>For the purposes of this Agreement, notices, demands and all other
communications provided for in this Agreement shall be in writing and shall be
deemed to have been duly given when delivered or (unless otherwise specified)
mailed by United States certified or registered mail, return receipt requested,
postage prepaid, addressed as follows:</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" style="border-collapse:collapse;margin-left:72.5pt;">
 <tr>
  <td width="54" valign="top" style="padding:0in .5pt 0in .5pt;width:40.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(a)</font></b></p>
  </td>
  <td width="7" valign="bottom" style="padding:0in .5pt 0in .5pt;width:5.4pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="528" valign="top" style="padding:0in .5pt 0in .5pt;width:396.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">If to the Company, to:</font></p>
  </td>
 </tr>
 <tr>
  <td width="54" valign="top" style="padding:0in .5pt 0in .5pt;width:40.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="7" valign="bottom" style="padding:0in .5pt 0in .5pt;width:5.4pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="528" valign="top" style="padding:0in .5pt 0in .5pt;width:396.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="54" valign="top" style="padding:0in .5pt 0in .5pt;width:40.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="7" valign="bottom" style="padding:0in .5pt 0in .5pt;width:5.4pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="528" valign="top" style="padding:0in .5pt 0in .5pt;width:396.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pharmacopeia,&nbsp;Inc.</font></p>
  </td>
 </tr>
 <tr>
  <td width="54" valign="top" style="padding:0in .5pt 0in .5pt;width:40.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="7" valign="bottom" style="padding:0in .5pt 0in .5pt;width:5.4pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="528" valign="top" style="padding:0in .5pt 0in .5pt;width:396.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3000 Eastpark Blvd.</font></p>
  </td>
 </tr>
 <tr>
  <td width="54" valign="top" style="padding:0in .5pt 0in .5pt;width:40.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="7" valign="bottom" style="padding:0in .5pt 0in .5pt;width:5.4pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="528" valign="top" style="padding:0in .5pt 0in .5pt;width:396.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Cranbury, NJ 08512</font></p>
  </td>
 </tr>
 <tr>
  <td width="54" valign="top" style="padding:0in .5pt 0in .5pt;width:40.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="7" valign="bottom" style="padding:0in .5pt 0in .5pt;width:5.4pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="528" valign="top" style="padding:0in .5pt 0in .5pt;width:396.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Attn.: General Counsel</font></p>
  </td>
 </tr>
 <tr>
  <td width="54" valign="top" style="padding:0in .5pt 0in .5pt;width:40.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="7" valign="bottom" style="padding:0in .5pt 0in .5pt;width:5.4pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="528" valign="top" style="padding:0in .5pt 0in .5pt;width:396.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="54" valign="top" style="padding:0in .5pt 0in .5pt;width:40.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">(b)</font></b></p>
  </td>
  <td width="7" valign="bottom" style="padding:0in .5pt 0in .5pt;width:5.4pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="528" valign="top" style="padding:0in .5pt 0in .5pt;width:396.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">If to Employee, to:</font></p>
  </td>
 </tr>
 <tr>
  <td width="54" valign="top" style="padding:0in .5pt 0in .5pt;width:40.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="7" valign="bottom" style="padding:0in .5pt 0in .5pt;width:5.4pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="528" valign="top" style="padding:0in .5pt 0in .5pt;width:396.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="54" valign="top" style="padding:0in .5pt 0in .5pt;width:40.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="7" valign="bottom" style="padding:0in .5pt 0in .5pt;width:5.4pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="528" valign="top" style="padding:0in .5pt 0in .5pt;width:396.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Rene Belder, M.D.</font></p>
  </td>
 </tr>
</table>

<p style="margin:0in 0in .0001pt 1.0in;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">or to such other address as
a party hereto shall designate to the other party by like notice, provided that
notice of a change of address shall be effective only upon receipt thereof.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">7.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">WITHHOLDING TAXES</u></b><b>.</b>&#160; All
payments under this Agreement shall be made subject to applicable tax
withholding, and the Company shall withhold from any payments under this
Agreement all federal, state and local taxes as the Company is required to withhold
pursuant to any law or governmental rule&nbsp;or regulation.&#160; Except as specifically provided otherwise in
this Agreement, Employee </p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">7</font></p>

<div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>

</div>
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<div style="font-family:Times New Roman;">

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">shall bear all expense of,
and be solely responsible for, all federal, state and local taxes due with
respect to any payment received under this Agreement.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">8.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">WAIVER</u></b><b>.</b>&#160; The
waiver by the Company or Employee of any breach of any provision of this
Agreement shall not operate or be construed as a waiver of any subsequent breach
by Employee or the Company, as applicable<b>,</b>
of any provision of this Agreement.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">9.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">SEVERABILITY</u></b><b>.</b>&#160; The
parties have carefully reviewed the provisions of this Agreement and agree that
they are fair and equitable.&#160; However, in
light of the possibility of differing interpretations of law and changes of
circumstances, the parties agree that in the event that any section, paragraph
or term of this Agreement shall be determined to be invalid or unenforceable by
any competent authority or tribunal for any reason, the remainder of this
Agreement shall be unaffected thereby and shall remain in full force and
effect.&#160; Moreover, if any of the
provisions of this Agreement is determined by a court of competent jurisdiction
to be excessively broad as to duration, activity, geographic application or
subject, it shall be construed by limiting or reducing it to the extent legally
permitted so as to be enforceable to the extent compatible with then applicable
law.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">10.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">SUCCESSORS AND ASSIGNS.</u></b>&#160; This
Agreement shall bind and inure to the benefit of the successors and assigns of
the Company and the heirs, executors or personal representatives of
Employee.&#160; This Agreement may not be
assigned by Employee.&#160; This Agreement may
be assigned to any successor in interest to the Company (including by way of
merger, consolidation or reorganization, or by way of any assignment of all or
substantially all of the Company&#146;s assets, business or properties), and
Employee hereby consents to such assignment.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">11.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">ENTIRE AGREEMENT; AMENDMENTS</u></b><b>.</b>&#160; This
Agreement, the Letter Agreement and the applicable bylaws and policies of the
Company, constitute the entire Agreement between the parties hereto and there
are no other understandings, agreements or representations, expressed or
implied.&#160; This Agreement supersedes any
and all prior or contemporaneous agreements, oral or written, concerning
Employee&#146;s employment and compensation.&#160;
This Agreement may be amended only in writing signed by Employee and the
Chief Executive Officer or the General Counsel of the Company.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">12.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">COUNTERPARTS</u></b>.&#160; This
Agreement may be executed in one or more counterparts, each of which shall be
deemed to be an original but all of which together will constitute one and the
same instrument.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">13.</font></b><font size="1" style="font-size:8.5pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><b><u style="font-weight:bold;">GOVERNING LAW; FORUM
SELECTION</u></b>.&#160; This Agreement shall be governed by and
construed in accordance with the laws (other than conflicts of laws principles)
of the State of New Jersey applicable to contracts executed in and to be
performed entirely within such State.&#160; The parties consent to jurisdiction and
laying of venue in the state and federal courts of New Jersey for purposes of
resolving disputes under this Agreement.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">14.</font></b><b><font size="1" style="font-size:8.5pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><u style="font-weight:bold;">COMPLIANCE WITH LAW</u></b><b>.</b>&#160; This
Agreement is intended to comply with the requirements of section 409A of the
Code, and specifically, with the short term deferral exemption of section 409A,
and shall in all respects be administered in accordance with section 409A.&#160; Notwithstanding anything in the Agreement to
the contrary, distributions may only be made under the Agreement upon an event
and in a manner permitted by section 409A of the Code or an applicable
exemption.&#160; All payments to be made upon
a termination of employment under this Agreement may only be made upon a
&#147;separation from service&#148; under section 409A.&#160;
In no event may Employee, directly or indirectly, designate the calendar
year of payment.&#160; For purposes of section
409A of the Code, each payment made under this Agreement shall be treated as a
separate payment.&#160; All reimbursements and
in-kind benefits provided under this Agreement shall be made or provided in
accordance with the requirements of section 409A of the Code, including, where
applicable, the requirement that (a)&nbsp;any reimbursement shall be for </p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">8</font></p>

<div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>

</div>
<!-- SEQ.=1,FOLIO='8',FILE='C:\JMS\saaron\08-24167-1\task3142695\24167-1-kk.htm',USER='105192',CD='Sep 23 21:48 2008' -->


<br clear="all" style="page-break-before:always;">


<div style="font-family:Times New Roman;">

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">expenses incurred during
Employee&#146;s lifetime (or during a shorter period of time specified in this
Agreement), (b)&nbsp;the amount of expenses eligible for reimbursement, or
in-kind benefits provided, during a calendar year may not affect the expenses
eligible for reimbursement, or in-kind benefits to be provided, in any other
calendar year, (c)&nbsp;the reimbursement of an eligible expense will be made
on or before the last day of the calendar year following the year in which the
expense is incurred, and (d)&nbsp;the right to reimbursement or in-kind
benefits is not subject to liquidation or exchange for another benefit.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">IN WITNESS
WHEREOF</font></b>, the parties
hereto have executed this Agreement as of the date first set forth above.</p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;">
 <tr>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="351" colspan="5" valign="top" style="padding:0in .5pt 0in .5pt;width:263.2pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">PHARMACOPEIA,
  INC.</font></b></p>
  </td>
  <td width="1" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="1" style="border:none;font-size:10.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="351" colspan="5" valign="top" style="padding:0in .5pt 0in .5pt;width:263.2pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="1" style="border:none;font-size:10.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="351" colspan="5" valign="top" style="padding:0in .5pt 0in .5pt;width:263.2pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="19" colspan="3" valign="top" style="padding:0in .5pt 0in .5pt;width:14.35pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By</font></p>
  </td>
  <td width="332" colspan="2" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in .5pt 0in .5pt;width:248.85pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ Joseph A. Mollica</font></p>
  </td>
  <td width="1" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="19" colspan="3" valign="top" style="padding:0in .5pt 0in .5pt;width:14.35pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="332" colspan="2" valign="top" style="border:none;padding:0in .5pt 0in .5pt;width:248.85pt;">
  <p style="margin:0in 0in .0001pt 23.0pt;text-autospace:none;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Joseph
  A. Mollica, Ph.D.</font></p>
  </td>
  <td width="1" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="19" colspan="3" valign="top" style="padding:0in .5pt 0in .5pt;width:14.35pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="332" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:248.85pt;">
  <p style="margin:0in 0in .0001pt 23.0pt;text-autospace:none;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Chairman
  of the Board and</font></p>
  </td>
  <td width="1" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="1" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="19" colspan="3" valign="top" style="padding:0in .5pt 0in .5pt;width:14.35pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="332" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:248.85pt;">
  <p style="margin:0in 0in .0001pt 23.0pt;text-autospace:none;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Interim
  President and Chief Executive Officer</font></p>
  </td>
 </tr>
 <tr>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="351" colspan="5" valign="top" style="padding:0in .5pt 0in .5pt;width:263.2pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="1" style="border:none;font-size:10.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="1" style="border:none;font-size:10.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="351" colspan="5" valign="top" style="padding:0in .5pt 0in .5pt;width:263.2pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="1" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="351" colspan="5" valign="top" style="padding:0in .5pt 0in .5pt;width:263.2pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">EMPLOYEE</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="1" style="border:none;font-size:10.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="351" colspan="5" valign="top" style="padding:0in .5pt 0in .5pt;width:263.2pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="1" style="border:none;font-size:10.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="351" colspan="5" valign="top" style="padding:0in .5pt 0in .5pt;width:263.2pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="18" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:13.6pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By</font></p>
  </td>
  <td width="333" colspan="3" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in .5pt 0in .5pt;width:249.6pt;">
  <p style="margin:0in 0in .0001pt 23.05pt;text-autospace:none;text-indent:-10.1pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/
  Rene Belder</font></p>
  </td>
  <td width="1" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="358" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:268.7pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="11" colspan="2" valign="bottom" style="padding:0in .5pt 0in .5pt;width:8.1pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="18" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:13.6pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="333" colspan="3" valign="top" style="border:none;padding:0in .5pt 0in .5pt;width:249.6pt;">
  <p style="margin:0in 0in .0001pt 23.05pt;text-autospace:none;text-indent:-10.1pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Rene
  Belder, M.D.</font></p>
  </td>
  <td width="1" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:0in 0in .0001pt;">&nbsp;</p></td>
 </tr>
 <tr height="0">
  <td width="1" style="border:none;"></td>
  <td width="358" style="border:none;"></td>
  <td width="1" style="border:none;"></td>
  <td width="10" style="border:none;"></td>
  <td width="1" style="border:none;"></td>
  <td width="17" style="border:none;"></td>
  <td width="1" style="border:none;"></td>
  <td width="1" style="border:none;"></td>
  <td width="331" style="border:none;"></td>
  <td width="1" style="border:none;"></td>
 </tr>
</table>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">9</font></p>

<div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>

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<div>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><b><u><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">EXHIBIT A</font></u></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">&nbsp;</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><b><u><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">General Release</font></u></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">IN CONSIDERATION OF the
terms and conditions contained in the Second Amended and Restated Severance
Agreement, dated as of the 18th day of September, 2008, (the &#147;<u>Severance Agreement</u>&#148;) by and
between Rene Belder, M.D. (&#147;<u>Employee</u>&#148;)
and Pharmacopeia,&nbsp;Inc. (the &#147;<u>Company</u>&#148;),
and for other good and valuable consideration, the receipt of which is hereby
acknowledged, Employee on behalf of Employee and his or her heirs, executors,
administrators, and assigns, releases and discharges the Company and its
subsidiaries, divisions, affiliates and parents, and their respective past,
current and future officers, directors, employees, agents, and/or owners, and
their respective successors, and assigns and any other person or entity claimed
to be jointly or severally liable with the Company or any of the aforementioned
persons or entities (collectively the &#147;<u>Released Parties</u>&#148;) from any and all manner of actions and
causes of action, suits, debts, dues, accounts, bonds, covenants, contracts,
agreements, judgments, charges, claims, and demands whatsoever (&#147;<u>Claims</u> &#147;) which Employee and his
heirs, executors, administrators, and assigns have, had, or may hereafter have,
against the Released Parties or any of them arising out of or by reason of any
cause, matter, or thing whatsoever from the beginning of the world to the date
hereof.&#160; This General Release of Claims
includes, without limitation, any and all matters relating to Employee&#146;s
employment by the Company and the cessation thereof, and any and all matters
arising under any federal, state, or local statute, rule, or regulation, or
principle of contract law or common law, including but not limited to, the
Family and Medical Leave Act of 1993, <u>as</u>  <u>amended</u>,
29 U.S.C. &#167;&#167; 2601 <u>et</u>  <u>seq</u>., Title VII of the Civil
Rights Act of 1964, <u>as</u>  <u>amended</u>, 42 U.S.C. &#167;&#167; 2000 <u>et</u>  <u>seq</u>., the Age Discrimination in Employment Act of 1967, <u>as</u>  <u>amended</u>, 29 U.S.C. &#167;&#167; 621 <u>et</u>  <u>seq</u>.
(the &#147;<u>ADEA</u>&#148;), the
Americans with Disabilities Act of 1990, <u>as</u>  <u>amended</u>,
42 U.S.C. &#167;&#167; 12101 <u>et</u>  <u>seq</u>., the Worker Adjustment and
Retraining Notification Act of 1988, <u>as</u>
<u>amended</u>, 29 U.S.C. &#167;&#167;2101
<u>et</u>  <u>seq</u>., Employee Retirement Income
Security Act of 1974, <u>as</u>  <u>amended</u>, 29 U.S.C. &#167;&#167; 1001 <u>et</u>  <u>seq</u>. (&#147;<u>ERISA</u>&#148;),
the New Jersey Law Against Discrimination, N.J.S.A. 10:15-1, et seq., the New
Jersey Conscientious Executive Protection Act, N.J.S.A. 34:19-1 to 19-8, the
New Jersey Wage and Hour Act, N.J.S.A. 34-11-56a, et seq., and any other
equivalent or similar federal, state, or local statute; provided, however, that
Employee does not release or discharge the Released Parties from (i)&nbsp;any
of the Company&#146;s obligations to Employee under the Severance Agreement, and
(ii)&nbsp;any vested benefits to which Employee may be entitled under any
employee benefit plan or program subject to ERISA.&#160; It is understood that nothing in this General
Release is to be construed as an admission on behalf of the Released Parties of
any wrongdoing with respect to Employee, any such wrongdoing being expressly
denied.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Employee represents and
warrants that Employee fully understands the terms of this General Release,
that Employee is hereby advised to consult with legal counsel before signing,
and that Employee knowingly and voluntarily, of Employee&#146;s own free will,
without any duress, being fully informed, and after due deliberation, accepts
its terms and signs below as Employee&#146;s own free act.&#160; Except as otherwise provided herein, Employee
understands that as a result of executing this General Release, Employee will
not have the right to assert that the Company or any other of the Released
Parties unlawfully terminated Employee&#146;s employment or violated any of
Employee&#146;s rights in connection with Employee&#146;s employment or otherwise.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Employee further represents
and warrants that Employee has not filed, and will not initiate, or cause to be
initiated on Employee&#146;s behalf any complaint, charge, claim, or proceeding
against any of the Released Parties before any federal, state, or local agency,
court, or other body relating to any claims barred or released in this General
Release thereof, and will not voluntarily participate in such a
proceeding.&#160; However, nothing in this
General Release shall preclude or prevent Employee from filing a claim, which
challenges the validity of this General Release solely with respect to
Employee&#146;s waiver of any losses arising under the ADEA. Employee shall not
accept any relief obtained on Employee&#146;s behalf </font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">A-1</font></p>

<div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>

</div>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">by any government agency,
private party, class, or otherwise with respect to any claims covered by this
General Release.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Employee may take twenty-one
(21) days to consider whether to execute this General Release.&#160; Upon Employee&#146;s execution of this General
Release, Employee will have seven (7)&nbsp;days after such execution in which Employee
may revoke such execution.&#160; In the event
of revocation, Employee must present written notice of such revocation to the
Company&#146;s Chief Executive Officer.&#160; If
seven (7)&nbsp;days pass without receipt of such notice of revocation, this
General Release shall become binding and effective on the eighth (8th) day
after the execution hereof (the &#147;<u>Effective
Date</u>&#148;).</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">INTENDING TO BE LEGALLY
BOUND, Employee hereby sets Employee&#146;s hand below:</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;">
 <tr>
  <td width="392" valign="top" style="padding:0in .5pt 0in .5pt;width:294.0pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="328" colspan="2" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in .5pt 0in .5pt;width:246.0pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="392" valign="top" style="padding:0in .5pt 0in .5pt;width:294.0pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="328" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:246.0pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="392" valign="top" style="padding:0in .5pt 0in .5pt;width:294.0pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="40" valign="top" style="padding:0in .5pt 0in .5pt;width:30.0pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="288" valign="top" style="padding:0in .5pt 0in .5pt;width:3.0in;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="392" valign="top" style="padding:0in .5pt 0in .5pt;width:294.0pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="40" valign="top" style="padding:0in .5pt 0in .5pt;width:30.0pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Dated:</font></p>
  </td>
  <td width="288" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in .5pt 0in .5pt;width:3.0in;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
</table>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">*&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;*&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;*</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">NOTARIZATION</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;">
 <tr>
  <td width="50" valign="top" style="padding:0in .5pt 0in .5pt;width:37.85pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">State of</font></p>
  </td>
  <td width="250" colspan="3" valign="top" style="padding:0in .5pt 0in .5pt;width:187.8pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="86" valign="top" style="padding:0in .5pt 0in .5pt;width:.9in;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="19" valign="top" style="padding:0in .5pt 0in .5pt;width:14.35pt;">
  <p style="margin:0in 0in .0001pt 10.0pt;text-autospace:none;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">)</font></p>
  </td>
  <td width="314" valign="top" style="padding:0in .5pt 0in .5pt;width:235.2pt;">
  <p style="margin:0in 0in .0001pt 60.0pt;text-autospace:none;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="86" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:64.85pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">County of</font></p>
  </td>
  <td width="214" valign="top" style="padding:0in .5pt 0in .5pt;width:160.15pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="87" colspan="2" valign="top" style="padding:0in .5pt 0in .5pt;width:65.45pt;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="19" valign="top" style="padding:0in .5pt 0in .5pt;width:14.35pt;">
  <p style="margin:0in 0in .0001pt 10.0pt;text-autospace:none;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">)</font></p>
  </td>
  <td width="314" valign="top" style="padding:0in .5pt 0in .5pt;width:235.2pt;">
  <p style="margin:0in 0in .0001pt 60.0pt;text-autospace:none;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">ss.</font></p>
  </td>
 </tr>
 <tr height="0">
  <td width="50" style="border:none;"></td>
  <td width="36" style="border:none;"></td>
  <td width="214" style="border:none;"></td>
  <td width="1" style="border:none;"></td>
  <td width="86" style="border:none;"></td>
  <td width="19" style="border:none;"></td>
  <td width="314" style="border:none;"></td>
 </tr>
</table>

<p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">On this
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; day of
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
in the year &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; before
me, the undersigned, personally appeared
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;;
personally known to me or proved to me on the basis of satisfactory evidence to
be the individual whose name is subscribed to the within instrument, and
acknowledged to me that he executed the same in his capacity as an individual,
and that by his signature on the instrument he executed such instrument, and
that such individual made such appearance before the undersigned.</font></p>

<p style="margin:0in 0in .0001pt;text-autospace:none;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;">
 <tr>
  <td width="360" valign="top" style="padding:0in .5pt 0in .5pt;width:3.75in;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="360" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in .5pt 0in .5pt;width:3.75in;">
  <p style="margin:0in 0in .0001pt 10.0pt;text-autospace:none;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="360" valign="top" style="padding:0in .5pt 0in .5pt;width:3.75in;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="360" valign="top" style="border:none;padding:0in .5pt 0in .5pt;width:3.75in;">
  <p style="margin:0in 0in .0001pt;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Notary Public</font></p>
  </td>
 </tr>
</table>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">A-2</font></p>

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</div>
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