Aptinyx Inc.
EX-10.5
<DOCUMENT>
<TYPE>EX-10.5
<SEQUENCE>3
<FILENAME>aptx-20211231xex10d5.htm
<DESCRIPTION>EX-10.5
<TEXT>
<!--Enhanced HTML document created with Toppan Merrill Bridge  9.11.0.85--><!--Created on: 3/23/2022 07:35:05 PM (UTC)--><!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"><html><head><meta charset="UTF-8"><title></title></head><body><div style="margin-top:30pt;"></div><div style="max-width:100%;padding-left:11.76%;padding-right:11.76%;position:relative;"><div style="clear:both;max-width:100%;position:relative;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';visibility:hidden;">&#8203;</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;text-align:right;margin:0pt 0pt 8pt 0pt;"><b style="font-family:'Times New Roman','Times','serif';font-weight:bold;">Exhibit 10.5</b><font style="font-size:11pt;"><a name="8920-2-LW_Exhibit10_5_082558"></a></font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;text-align:center;margin:0pt 0pt 8pt 0pt;"><b style="font-family:'Times New Roman','Times','serif';font-weight:bold;">APTINYX INC.</b></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;text-align:center;margin:0pt 0pt 8pt 0pt;"><b style="font-family:'Times New Roman','Times','serif';font-weight:bold;">NON-EMPLOYEE DIRECTOR COMPENSATION POLICY</b></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">The purpose of this </font><b style="font-family:'Times New Roman','Times','serif';font-weight:bold;">NON-EMPLOYEE DIRECTOR COMPENSATION POLICY</b><font style="font-family:'Times New Roman','Times','serif';"> of Aptinyx Inc. (the &#8220;</font><b style="font-family:'Times New Roman','Times','serif';font-weight:bold;">Company</b><font style="font-family:'Times New Roman','Times','serif';">&#8221;), is to provide a total compensation package that enables the Company to attract and retain, on a long- term basis, high-caliber directors who are not employees or officers of the Company or its subsidiaries. In furtherance of the purpose stated above, all non-employee directors shall be paid compensation for services provided to the Company as set forth below:</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';font-size:10pt;text-decoration:underline;visibility:hidden;">&#8203;</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><u style="font-family:'Times New Roman','Times','serif';text-decoration:underline;text-decoration-color:#000000;">Cash Retainers</u></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';font-size:10pt;text-decoration:underline;visibility:hidden;">&#8203;</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><u style="font-family:'Times New Roman','Times','serif';text-decoration:underline;text-decoration-color:#000000;">Annual Retainer for Board Membership</u><font style="font-family:'Times New Roman','Times','serif';">: $35,000 for general availability and participation in meetings and conference calls of our Board of Directors, to be paid quarterly in arrears, pro-rated based on the number of actual days served by the director during such calendar quarter.</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';font-size:10pt;visibility:hidden;">&#8203;</font></p><div style="padding-left:3pt;" align="left"><table style="border-collapse:collapse;font-size:16pt;height:max-content;padding-left:3pt;padding-right:3pt;width:99.35%;"><tr><td style="background-color:#cceeff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><u style="font-family:'Times New Roman','Times','serif';text-decoration:underline;text-decoration-color:#000000;">Additional Annual Retainer for Non-Executive Chair of the Board:</u></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.36%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">$</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:14.26%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;text-align:right;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">30,000</font></p></td></tr><tr><td style="background-color:#ffffff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#ffffff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="4" style="background-color:#ffffff;vertical-align:top;width:16.63%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td></tr><tr><td style="background-color:#cceeff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><u style="font-family:'Times New Roman','Times','serif';text-decoration:underline;text-decoration-color:#000000;">Additional Retainers for Committee Membership:</u></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="4" style="background-color:#cceeff;vertical-align:top;width:16.63%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td></tr><tr><td style="background-color:#ffffff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#ffffff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="4" style="background-color:#ffffff;vertical-align:top;width:16.63%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td></tr><tr><td style="background-color:#cceeff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">Audit Committee Chair:</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.36%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">$</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:14.26%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;text-align:right;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">15,000</font></p></td></tr><tr><td style="background-color:#ffffff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#ffffff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="4" style="background-color:#ffffff;vertical-align:top;width:16.63%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td></tr><tr><td style="background-color:#cceeff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">Audit Committee member:</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.36%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">$</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:14.26%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;text-align:right;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">7,500</font></p></td></tr><tr><td style="background-color:#ffffff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#ffffff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="4" style="background-color:#ffffff;vertical-align:top;width:16.63%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td></tr><tr><td style="background-color:#cceeff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">Compensation and Management Development Committee Chair:</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.36%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">$</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:14.26%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;text-align:right;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">10,000</font></p></td></tr><tr><td style="background-color:#ffffff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#ffffff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="4" style="background-color:#ffffff;vertical-align:top;width:16.63%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td></tr><tr><td style="background-color:#cceeff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">Compensation and Management Development Committee member:</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.36%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">$</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:14.26%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;text-align:right;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">5,000</font></p></td></tr><tr><td style="background-color:#ffffff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#ffffff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="4" style="background-color:#ffffff;vertical-align:top;width:16.63%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td></tr><tr><td style="background-color:#cceeff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">Nominating and Corporate Governance Committee Chair:</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.36%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">$</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:14.26%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;text-align:right;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">8,000</font></p></td></tr><tr><td style="background-color:#ffffff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#ffffff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="4" style="background-color:#ffffff;vertical-align:top;width:16.63%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td></tr><tr><td style="background-color:#cceeff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">Nominating and Corporate Governance Committee member:</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.36%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">$</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:14.26%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;text-align:right;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">4,000</font></p></td></tr><tr><td colspan="2" style="background-color:#ffffff;vertical-align:top;width:81.37%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#ffffff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="3" style="background-color:#ffffff;vertical-align:top;width:16.55%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td></tr><tr><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:81.37%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">Science and Medicine Committee Chair:</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.36%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">$</font></p></td><td style="background-color:#cceeff;vertical-align:top;width:14.19%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;text-align:right;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">8,000</font></p></td></tr></table></div></div></div><hr style="background-color:#000000;clear:both;color:#000000;height:2pt;line-height:0;margin-bottom:30pt;margin-left:11.76%;margin-right:11.76%;margin-top:30pt;page-break-after:always;width:76.47%;border-width:0;"><div style="max-width:100%;padding-left:11.76%;padding-right:11.76%;position:relative;"><div style="clear:both;max-width:100%;position:relative;min-height:3pt;"><div style="padding-left:3pt;" align="left"><table style="border-collapse:collapse;font-size:16pt;height:max-content;padding-left:3pt;padding-right:3pt;width:99.35%;"><tr><td style="background-color:#ffffff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#ffffff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="4" style="background-color:#ffffff;vertical-align:top;width:16.63%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td></tr><tr><td style="background-color:#cceeff;vertical-align:top;width:81.3%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">Science and Medicine Committee member:</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.06%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';line-height:1.28;visibility:hidden;">&#8203;</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:2.36%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">$</font></p></td><td colspan="2" style="background-color:#cceeff;vertical-align:top;width:14.26%;margin:0pt;padding:0pt 3pt 0pt 3pt;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.26;text-align:right;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">4,000</font></p></td></tr></table></div><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';font-size:10pt;text-decoration:underline;visibility:hidden;">&#8203;</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><u style="font-family:'Times New Roman','Times','serif';text-decoration:underline;text-decoration-color:#000000;">Equity Retainers</u></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';font-size:10pt;text-decoration:underline;visibility:hidden;">&#8203;</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><u style="font-family:'Times New Roman','Times','serif';text-decoration:underline;text-decoration-color:#000000;">Initial Award</u><font style="font-family:'Times New Roman','Times','serif';">: An initial, one-time equity award (the &#8220;</font><b style="font-family:'Times New Roman','Times','serif';font-weight:bold;">Initial Award</b><font style="font-family:'Times New Roman','Times','serif';">&#8221;) of a stock option to purchase 80,000 shares shall be granted to</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;text-align:center;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">1</font><font style="font-size:11pt;"><a name="8920-2-LW_PB_1_082101_3736"></a></font></p><div style="height:0pt;position:relative;width:100%;"><div style="height:3pt;left:0%;position:absolute;top:6pt;width:505.5pt;z-index:251658240;"><div style="height:100%;left:0pt;padding-bottom:1.5pt;position:relative;top:1.5pt;width:504pt;"><img src="aptx-20211231xex10d5001.jpg" alt="Graphic" style="width:504pt;"></div></div></div><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';visibility:hidden;">&#8203;</font></p></div></div><hr style="background-color:#000000;clear:both;color:#000000;height:2pt;line-height:0;margin-bottom:30pt;margin-left:11.76%;margin-right:11.76%;margin-top:30pt;page-break-after:always;width:76.47%;border-width:0;"><div style="max-width:100%;padding-left:11.76%;padding-right:11.76%;position:relative;"><div style="clear:both;max-width:100%;position:relative;"><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">each new non-employee director upon his or her election to the Board of Directors, which stock option shall vest over a three-year period with one-third of the option shares vesting on the first anniversary of the date of grant and the remaining two-thirds vesting in ratable monthly installments thereafter;</font><i style="font-family:'Times New Roman','Times','serif';font-style:italic;"> provided</i><font style="font-family:'Times New Roman','Times','serif';">, </font><i style="font-family:'Times New Roman','Times','serif';font-style:italic;">however</i><font style="font-family:'Times New Roman','Times','serif';">, that all vesting shall cease if the director resigns from the Board of Directors or otherwise ceases to serve as a director of the Company. Such stock option shall have a per share exercise price equal to the Fair Market Value (as defined in the Company&#8217;s 2018 Stock Option and Incentive Plan) of the Company&#8217;s common stock on the date of grant expire ten years from the date of grant.</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:11pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';font-size:10pt;text-decoration:underline;visibility:hidden;">&#8203;</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><u style="font-family:'Times New Roman','Times','serif';text-decoration:underline;text-decoration-color:#000000;">Annual Award</u><font style="font-family:'Times New Roman','Times','serif';">: On each date of the Company&#8217;s Annual Meeting of Stockholders (the &#8220;</font><b style="font-family:'Times New Roman','Times','serif';font-weight:bold;">Annual Meeting</b><font style="font-family:'Times New Roman','Times','serif';">&#8221;), each continuing non-employee member of the Board, other than a director receiving an Initial Award, will receive an annual equity award (the &#8220;</font><b style="font-family:'Times New Roman','Times','serif';font-weight:bold;">Annual Award</b><font style="font-family:'Times New Roman','Times','serif';">&#8221;) in the form of a stock option to purchase 40,000 shares of the Company&#8217;s common stock, which shall vest in ratable monthly installments over one year from the date of grant; </font><i style="font-family:'Times New Roman','Times','serif';font-style:italic;">provided</i><font style="font-family:'Times New Roman','Times','serif';">, </font><i style="font-family:'Times New Roman','Times','serif';font-style:italic;">however</i><font style="font-family:'Times New Roman','Times','serif';white-space:pre-wrap;">, that all vesting shall cease if the director resigns from the Board of Directors or otherwise ceases to serve as a director, unless the Board of Directors determines that the circumstances warrant continuation of vesting. Such stock option shall have a per share exercise price equal to the Fair Market Value (as defined in the Company&#8217;s 2018 Stock Option and Incentive Plan) of the Company&#8217;s common stock on the date of grant and expire ten years from the date of grant.  In the event a member of the Board is appointed to the Board of Directors prior to an Annual Meeting, that member of the Board shall receive, at the time of their appointment and in addition to their Initial Award, an Annual Award pro rated for the portion of the year prior to the Annual Meeting the new member of the Board is expected to serve, which award shall vest in ratable monthly installments from the date of grant over the period from appointment to the Annual Meeting.</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><u style="font-family:'Times New Roman','Times','serif';text-decoration:underline;text-decoration-color:#000000;">Expenses</u><font style="font-family:'Times New Roman','Times','serif';">: The Company will reimburse all reasonable out-of-pocket expenses incurred by non-employee directors in attending meetings of the Board or any Committee.</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">Adopted May 28, 2018, subject to effectiveness of the Company&#8217;s Registration Statement on Form S-1, and as amended on May 15, 2019, August 26, 2020, and February 24, 2022.</font></p><p style="font-family:'Calibri','Helvetica','sans-serif';font-size:10pt;line-height:1.28;text-align:center;margin:0pt 0pt 8pt 0pt;"><font style="font-family:'Times New Roman','Times','serif';">2</font><font style="font-size:11pt;"><a name="8920-2-LW_PB_2_082116_9621"></a></font></p></div></div><hr style="background-color:#000000;clear:both;color:#000000;height:2pt;line-height:0;margin-left:11.76%;margin-right:11.76%;margin-top:30pt;page-break-after:avoid;width:76.47%;border-width:0;"></body></html>
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