TARGETED GENETICS CORP /WA/
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<H1 ALIGN=center><FONT FACE="Times New Roman, Times, Serif" SIZE=3>Exhibit 10.1 </FONT></H1>
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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&#147;[ * ]&#148;&nbsp;=&nbsp;Portions of this
exhibit have been omitted pursuant to a request for confidential treatment filed with the
Securities and Exchange Commission or SEC. The omitted portions of this exhibit have been
filed separately with the SEC. </FONT></P>
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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>SIXTH AMENDMENT TO
LEASE AGREEMENT </FONT></H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This
SIXTH AMENDMENT TO LEASE AGREEMENT (this &#147;Amendment&#148;) is entered into by and
between Ironwood Apartments, Inc., as successor to Metropolitan Federal Savings and Loan
Association (&#147;Landlord&#148;) and Targeted Genetics Corporation (&#147;Tenant&#148;). </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Landlord
and Tenant are parties to that certain Olive Way Building Lease dated November 20, 1992,
as modified by that certain First Amendment to Olive Way Building Lease dated December 10,
1994, that certain Second Amendment to Lease Agreement executed on June 12, 1996 and May
22, 1996, that certain Third Amendment to Lease Agreement dated October 30, 1998, that
certain Fourth Amendment to Lease Agreement dated February 5, 2001, and that certain Fifth
Amendment to Lease Agreement dated June 20, 2003 (as modified, the &#147;Lease&#148;). </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Landlord
and Tenant wish to expand the Premises to include an expanded shipping and receiving area
in the Building. Capitalized terms used herein shall have the meanings set forth in the
Lease. </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Landlord
and Tenant hereby amend the Lease as follows: </FONT></P>

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     <P><FONT FACE="Times New Roman, Times, Serif" SIZE=2><B>1</B>.&nbsp;&nbsp;&nbsp;&nbsp;
          <B>EXPANSION. </B>  As of November 1, 2003 (the &#147;Effective Date&#148;), the
          Premises are expanded to include the additional shipping and receiving area
          marked on attached Exhibit A (the &#147;New Shipping Area&#148;). Tenant
          accepted the space in AS-IS condition and is currently constructing the demising
          walls and other improvements for the New Shipping Area. When the buildout is
          complete, Tenant will engage an architect to measure the rentable square footage
          of the New Shipping Area, and an Acknowledgement of the final measurement, along
          with a drawing of the area showing the final measurement calculation, shall be
          substituted for the attached Exhibit A. The Acknowledgement will follow the
          format used for the area added to the Premises under the Fourth Amendment to the
          Lease. The New Shipping Area is added to the Lease for all purposes, including
          application of the Base Rent rate set forth in Section 6.01 of the Lease. </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Between the Effective Date and the
date that the measurement is completed, the parties agree to use [ * ] as the estimated
rentable square footage of the New Shipping Area for purposes of determining the Base Rent
for that space ([ * ]times current rental rate of [ * ] divided by 12 = [ * ] per month).
When the actual measurement is received, the Base Rent for the New Shipping Area will be
calculated and the parties shall adjust the estimated Base Rent payments made on and after
the Effective Date to the correct amount and reflect that adjustment in the
Acknowledgement. </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Pursuant to Section 11.05 of the
Lease, Landlord will provide the Expansion Space Tenant Improvement Allowance for costs
incurred in construction of the New Shipping Area of [ * ] per rentable square foot ([ *
]/rsf times 65 months). </FONT></P>
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     <P><FONT FACE="Times New Roman, Times, Serif" SIZE=2><B>2.&nbsp;&nbsp;&nbsp;&nbsp;
          NO OTHER AMENDMENTS. </B>  Except as modified by this Amendment and by the
          Amendments referenced above, the Lease remains in full force and effect and has
          not been modified or amended. </FONT></P>

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<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;DATED:
November 7, 2003.</FONT></P>


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<TD WIDTH=50%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
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<FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>LANDLORD:</B><BR>
<BR>

IRONWOOD APARTMENTS, INC.,<BR>
a Washington corporation<BR><BR>


By:&nbsp;&nbsp;
<U>/s/ John Stone&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;John Stone, President
<BR><BR><BR><BR>


<B>TENANT:</B><BR>
<BR>

TARGETED GENETICS CORPORATION<BR>
<BR>

By:&nbsp;&nbsp;
<U>/s/ Todd E. Simpson&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Its VP Finance &amp; CFO </FONT>
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STATE OF WASHINGTON<BR>
<BR>

COUNTY OF SPOKANE</FONT></TD>
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)<BR>
)<BR>
)</FONT></TD>
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<BR>
ss.<BR>
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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;I
certify that I know or have  satisfactory  evidence  that John Stone is the person who
appeared before me, and said  person  acknowledged  that  he/she  signed  this
 instrument,  on oath  stated that he/she was authorized to execute the instrument and
 acknowledged it as the President of Ironwood  Apartments,  Inc. to be the free and
voluntary act of such party for the uses and purposes mentioned in this instrument. </FONT></P>


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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Dated:
November 7, 2003. </FONT></P>

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<TD WIDTH=40%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
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<FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U>/s/ Durinda M. Howard&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
(Signature of Notary Public)<BR>
<BR>


<U>Durinda M. Howard&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
(Printed Name of Notary Public)<BR>
<BR>


My Appointment expires&nbsp;<U>2-27-07&nbsp;&nbsp;</U> </FONT>
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STATE OF WASHINGTON<BR>
<BR>

COUNTY OF SPOKANE</FONT></TD>
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)<BR>
)<BR>
)</FONT></TD>
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<BR>
ss.<BR>
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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;I
certify that I know or have  satisfactory  evidence  that John Stone is the person who
appeared before me, and said  person  acknowledged  that  he/she  signed  this
 instrument,  on oath  stated that he/she was authorized to execute the instrument and
 acknowledged it as the President of Ironwood  Apartments,  Inc. to be the free and
voluntary act of such party for the uses and purposes mentioned in this instrument. </FONT></P>


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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Dated:
November 7, 2003. </FONT></P>

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<TD WIDTH=40%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
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<FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U>/s/
Jonathan K. Wright&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
(Signature of Notary Public)<BR>
<BR>


<U>Jonathan K. Wright&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
(Printed Name of Notary Public)<BR>
<BR>


My Appointment expires&nbsp;<U>October 3, 2005</U> </FONT>
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<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="4"><B>EXHIBIT A</B> </FONT> </P>

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     <P ALIGN=CENTER><B>[&nbsp;*&nbsp;]</B></P>
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