CHIRON CORP
EXHIBIT 10.316
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<DESCRIPTION>EXHIBIT 10.316
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<P><FONT SIZE=2><B>[**] CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH
RESPECT TO THE OMITTED PORTIONS.</B></FONT></P>

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<BR></FONT><FONT SIZE=2><B>BLOOD SCREENING<BR>  <BR>    HIV PROBE LICENSE AGREEMENT<BR>  <BR>    between<BR>  <BR>    CHIRON CORPORATION<BR>  <BR>    F. HOFFMANN-LA ROCHE&nbsp;LTD.<BR>  <BR>    and<BR>  <BR>    ROCHE MOLECULAR SYSTEMS,&nbsp;INC.
<BR>  </B></FONT></P>

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<BR></FONT><FONT SIZE=2><B>BLOOD SCREENING HIV PROBE LICENSE AGREEMENT<BR>  TABLE OF CONTENTS    <BR>  </B></FONT></P>

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<TH WIDTH="92%" ALIGN="LEFT"><FONT SIZE=2>&nbsp;</FONT><BR></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="5%" ALIGN="CENTER"><FONT SIZE=1><B>Page</B></FONT><HR NOSHADE></TH>
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<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="92%"><FONT SIZE=2>RECITALS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2>3</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 1: DEFINITIONS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
3</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 2: LICENSE AND OPTION GRANTS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
7</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 3: PAYMENTS, ROYALTIES</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
9</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 4: RECORDS AND REPORTS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
9</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 5: OTHER ACTIONS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
12</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 6: REPRESENTATIONS AND WARRANTIES</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
12</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 7: TERM AND TERMINATION</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
13</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 8: CONFIDENTIALITY</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
15</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 9: INDEMNITY</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
16</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 10: ALTERNATIVE DISPUTE RESOLUTION</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
16</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 11: MISCELLANEOUS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
18</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 12: FIELD RESTRICTIONS AND OTHER COVENANTS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
20</FONT></TD>
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ARTICLE 13: INFRINGEMENT BY THIRD PARTIES</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
21</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
ARTICLE 14: EUROPEAN COMMUNITY PROVISIONS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%" ALIGN="RIGHT"><FONT SIZE=2><BR>
22</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
EXHIBIT A: COMPENSATION TO CHIRON</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
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<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="92%"><FONT SIZE=2><BR>
EXHIBIT B: CHIRON PATENT LIST</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
EXHIBIT C: ROCHE PATENT LIST</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
EXHIBIT D: CHIRON LICENSED PRODUCTS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
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EXHIBIT E: FORM OF REPORT</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
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EXHIBIT F: EXISTING LICENSES</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
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<TD WIDTH="92%"><FONT SIZE=2><BR>
EXHIBIT G: REGIONS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
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<BR></FONT><FONT SIZE=2><B>BLOOD SCREENING HIV PROBE LICENSE AGREEMENT    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;This agreement (hereinafter "Agreement") is made by and between CHIRON CORPORATION, a Delaware corporation, of 4560 Horton Street, Emeryville, California 94608
(hereinafter referred to as "CHIRON"), F. HOFFMANN-LA ROCHE&nbsp;LTD., a Swiss corporation, of Grenzacherstrasse 124, Basel, Switzerland (hereinafter referred to as "ROCHE PARENT"), and
ROCHE MOLECULAR SYSTEMS,&nbsp;INC., a Delaware corporation, of 1145 Atlantic Avenue, Suite 100, Alameda, California 94501 (hereinafter referred to as "RMS" and collectively with ROCHE PARENT,
"ROCHE"). </FONT></P>

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<BR></FONT><FONT SIZE=2><B>BACKGROUND    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;WHEREAS, CHIRON and ROCHE currently own or control certain patent rights relating to the human immunodeficiency virus ("HIV"), as defined below. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;WHEREAS,
CHIRON and ROCHE entered into that certain Settlement Agreement dated as of October&nbsp;10, 2000 (the "Settlement Agreement") pertaining to the settlement of the certain
litigation matters described therein. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;WHEREAS,
in consideration of and subject to the execution and delivery of the Settlement Agreement, CHIRON granted licenses to ROCHE under certain patent rights relating to HIV for
use in assays for the detection of nucleic acid sequences for use in Blood Screening, subject to certain geographic and time limitations, under that certain Blood Screening HCV/HIV Probe License
Agreement dated as of October&nbsp;10, 2000 (the "Interim Agreement"). </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;WHEREAS,
CHIRON and ROCHE now desire to enter into a long term, worldwide collaboration in Blood Screening, superceding the terms and conditions of the Interim Agreement, all on the
terms and conditions set forth herein. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;NOW,
THEREFORE, in consideration of the above provisions and the mutual covenants contained herein, CHIRON and ROCHE hereby agree as follows: </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mc2030_article_1_definitions"> </A>
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<BR></FONT><FONT SIZE=2><B>ARTICLE 1<BR>  DEFINITIONS    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;In this Agreement the following words and phrases shall have the following meanings: </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.1&nbsp;"ADR"
means Alternative Dispute Resolution in accordance with Article&nbsp;10. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.2&nbsp;"Affiliate"
means an entity that directly, or indirectly through one or more intermediaries, controls or is controlled by or is under common control with, a
specified entity. For the purposes of this definition, "control" (including with correlative meanings, the terms "controlling", "controlled by" and "under common control with"), as applied to any
entity, means: (a)&nbsp;the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of that entity, whether through the ownership of voting
securities or by contract or otherwise; or (b)&nbsp;the ownership of at least fifty percent (50%) of the voting securities of that entity. Notwithstanding anything to the contrary contained herein,
"Affiliate" shall not include, in the case of CHIRON, Novartis AG or any Affiliate of Novartis AG, unless Novartis shall have acquired direct control of a majority of the Board of Directors of CHIRON.
Notwithstanding anything to the contrary contained herein, "Affiliate" shall not include, in the case of ROCHE, Genentech&nbsp;Inc. or any Affiliate of Genentech&nbsp;Inc., nor Laboratory
Corporation of America Holdings or any Affiliate of Laboratory Corporation of America Holdings. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.3&nbsp;"Authorized
Distributor" means a </FONT><FONT SIZE=2><I>bona fide</I></FONT><FONT SIZE=2>, unaffiliated distributor, but excluding any entity which is a Major IVD
Manufacturer (as defined below) that is not licensed in the Field (as defined below) under one or more of the CHIRON Licensed Patents (as defined below) or is affiliated with, or directly or
indirectly controlled by, such a Major IVD Manufacturer, except to the extent that such unlicensed Major IVD Manufacturer or its Affiliates distributes CHIRON Licensed Products for </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>3</FONT></P>

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<P><FONT SIZE=2>
ROCHE or its Affiliates on a local country basis and in the same manner in which it distributes other diagnostic products for ROCHE or its Affiliates and ROCHE and its Affiliates are not otherwise
selling CHIRON Licensed Products in such country. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.4&nbsp;"Blood
Screening" means the commercial use of products that detect nucleic acid sequences(s) for: (a)&nbsp;the screening of blood, plasma or blood components
intended for transfusion; and (b)&nbsp;confirmatory or supplemental testing of the same samples otherwise screened for purposes described in Section&nbsp;1.4(a). </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.5&nbsp;"Calendar
Quarter" means the three (3)&nbsp;month period beginning January&nbsp;1, April&nbsp;1, July&nbsp;1 or October&nbsp;1. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.6&nbsp;"Calendar
Year" means January&nbsp;1 through December&nbsp;31. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.7&nbsp;"CHIRON
Future HIV Sequence Patent Rights" means any and all Valid Claims Directed to HIV of United States and foreign patents and patent applications:
(a)&nbsp;which are based upon inventions conceived or rights acquired [**] (as defined below); (b)&nbsp;are not CHIRON Licensed Patents (as defined below); (c)&nbsp;which
claim HIV nucleic acid sequence(s) or a method to use (other than in the manufacture of peptides) or detect such sequences specifically; (d)&nbsp;which are owned by, licensed to or otherwise
controlled by CHIRON or its Affiliates, with rights to license or sublicense; and (e)&nbsp;with respect to which CHIRON has the right to grant the option provided for in Section&nbsp;2.4 of this
Agreement. For purposes of this Agreement, an invention will be deemed to have been conceived if there is a patent, patent application, written invention disclosure statement or other tangible
document (whether or not witnessed) describing such invention. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.8&nbsp;"CHIRON
Licensed Patents" means Valid Claims Directed to HIV which cover the manufacture, use, sale, offer for sale or importation of a Products that are contained
within any of the following: (a)&nbsp;the patents and applications identified in Exhibit&nbsp;B and any continuation, continuation-in-part and divisional applications
therefrom; (b)&nbsp;any reissued or reexamined patents obtained from such patents and applications; (c)&nbsp;all foreign counterparts of such patents and applications; and (d)&nbsp;all future
patents and applications which are based on inventions conceived by CHIRON or its Affiliates on or before the Effective Date. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.9&nbsp;"CHIRON
Licensed Products" means Products which are used by, or for, or sold to an End User under circumstances, and in jurisdictions, such that in the absence of
the license granted under Section&nbsp;2.1 such use or sale would constitute an infringement of a Valid Claim of the CHIRON Licensed Patents, including without limitation the Products identified in
Exhibit&nbsp;D, as modified from time to time by mutual agreement of the parties or as determined in accordance with Section&nbsp;5.2. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.10&nbsp;"CHIRON
Non-HCV/HIV Analyte Patent Rights" means any and all Valid Claims of U.S. and foreign patents and patent applications: (a)&nbsp;which claim
any nucleic acid sequence(s) or transmissible disease-causing agent(s), other than HCV or HIV; (b)&nbsp;which is a blood borne, infectious disease or virus to the extent such Valid Claims cover the
detection of any nucleic acid sequence(s) or transmissible disease-causing agent(s) of such infectious disease or virus; (c)&nbsp;which are owned by, licensed to or otherwise controlled by CHIRON or
its Affiliates, with right to license or sublicense; and (d)&nbsp;with respect to which CHIRON has the right to grant the option provided for in Section&nbsp;2.4 of this Agreement. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.11&nbsp;"CHIRON
Optioned Rights" means the CHIRON Future HIV Sequence Patent Rights and the CHIRON Non-HCV/HIV Analyte Patent Rights. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.12&nbsp;"Directed
to HIV" means that the claim or technology in question is directed to methods, compositions, reagents or kits specifically for use in nucleic
acid-based diagnostic assays for the detection of HIV nucleic acid sequence(s), or specifically for use in the manufacture of any compositions or reagents for use in, or manufacture of
nucleic acid-based diagnostic assays for </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>4</FONT></P>

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<P><FONT SIZE=2>
detection of HIV nucleic acid sequence(s) (excluding, for example, PCR claims and technology and other methods for detection of nucleic acid sequence(s) generally which involve nucleic acid
amplification). The terminology "specifically for use" as used in this Section&nbsp;1.12, is intended to exclude inventions suitable for use with viruses or analytes other than HIV (including by way
of example and not by way of limitation, inventions relating to PCR, or assay formats, improved expression systems, detectable labels, instrumentation, packaging and the like), which shall not be
considered "specifically for use" in HIV detection as contemplated by this Section&nbsp;1.12 and shall therefore not be considered as "Directed to HIV" hereunder. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.13&nbsp;"Earned
Royalty" and "Earned Royalty Amount" shall have the meanings specified in Paragraph&nbsp;1 of Exhibit&nbsp;A. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.14&nbsp;"Effective
Date" means [**]. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.15&nbsp;"End
User" means a person or entity who is a final purchaser of a Product, and whose use of a Product results in the Product's consumption, operation, destruction
or loss of activity. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.16&nbsp;"Existing
End Users" means as of May&nbsp;1, 2001, those End Users for which ROCHE has been selling and continues to sell a commercially significant volume of
the Products required by such End Users for Blood Screening use; provided however, that "Existing End Users" shall not include any End User located in [**] or the
[**]. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.17&nbsp;"Field"
means Blood Screening and Plasma Fractionation. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.18&nbsp;"Foundational
Patents" means the CHIRON Licensed Patents identified in Exhibit&nbsp;B which are stated therein to be Foundational Patents. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.19&nbsp;"HIV"
means any viral isolate of the human immunodeficiency virus classified as HIV by the International Committee on the Taxonomy of Viruses (or any body that
replaces such Committee) or any subtype of such isolate and further includes any isolate that is at least forty percent (40%) homologous to any such isolate and of the same genomic type and
substantially the same genomic organization, any isolate that has a genome that either hybridizes to or is substantially identical to any such isolate or its compliment, and any defective or modified
form of any of the above isolates. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.20&nbsp;"HIV
Diagnostics Agreement" means that certain HIV Probe License Agreement between CHIRON and ROCHE, dated as of October&nbsp;10, 2000, as amended from time to
time. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.21&nbsp;"Infringing
Third Party Sales" means (a)&nbsp;as to Blood Screening, sales by a Major IVD Manufacturer of Products for use in Blood Screening, and (b)&nbsp;as
to Plasma Fractionation, sales or use by any third party for use in Plasma Fractionation, which in either case: (i)&nbsp;infringe one or more of the CHIRON Licensed Patents, or (b)&nbsp;as to
which a license under one or more of the CHIRON Licensed Patents has been granted, but as to which the licensee is not paying royalties thereunder. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.22&nbsp;"Interim
Agreement" means the Blood Screening HCV/HIV Probe License Agreement by and between CHIRON and ROCHE dated as of October&nbsp;10, 2000, as amended from
time to time. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.23&nbsp;"</FONT><FONT
SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics" means the commercial use of products that detect nucleic acid sequence(s) of HIV in
individual human specimens, including the use of such products for diagnosis, prognosis, monitoring or classification purposes, including without limitation use for Transplantation but specifically
excluding use for Blood Screening and Plasma Fractionation. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.24&nbsp;"Licensed/Optioned
Patents" means the CHIRON Licensed Patents and the ROCHE Optioned Patents. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.25&nbsp;"Major
IVD Manufacturer" means a commercial entity (and its Affiliates) that manufactures, sells and engages in other commercial activities with respect to </FONT> <FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostic products and has a significant
marketing presence in one or more Regions. Major IVD Manufacturers include Abbott, </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>5</FONT></P>

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<P><FONT SIZE=2>
Bayer, Johnson&nbsp;&amp; Johnson, Pasteur, Sanofi, Dade Behring, Organon Teknika, Becton Dickinson, bioMerieux, BioRad, Fujirebio, Beckman Coulter, Visible Genetics, Innogenetics, and PE Corporation
and each of their successors and assigns and any other entity which commands in the future at least an equivalent presence as measured by total product sales as do any of the foregoing entities as of
the Effective Date in such Region. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.26&nbsp;"PCR"
means polymerase chain reaction technology. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.27&nbsp;"Plasma
Fractionation" means the commercial use of products that detect nucleic acid sequence(s) for the screening of plasma or blood components intended for use
in blood products (e.g., without limitation, immunoglobulins). </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.28&nbsp;"Product(s)"
means reagents, compositions or kits suitable for use in the Field. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.29&nbsp;"Region"
means one of the four (4)&nbsp;regions set forth on Exhibit&nbsp;G, as modified from time to time in accordance with Paragraph&nbsp;1(e) of
Exhibit&nbsp;A. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.30&nbsp;"Release
Screening" means, as to Plasma Fractionation only, the quality control testing of plasma samples that have previously been screened for the presence of
HIV using (a)&nbsp;a CHIRON Licensed Product for which at least the applicable Earned Royalty Amount has been paid, (b)&nbsp;any other Product for the detection of HIV licensed by CHIRON for sale
or use in Plasma Fractionation or (c)&nbsp;a Product sold or used by CHIRON for the detection of HIV. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.31&nbsp;"ROCHE
Future HIV Sequence Patent Rights" means any and all Valid Claims Directed to HIV of United States and foreign patents and patent applications:
(a)&nbsp;which are based on inventions conceived or rights acquired [**]; (b)&nbsp;are not ROCHE Optioned Patents (as defined below); (c)&nbsp;which claim HIV nucleic
acid sequence(s) or a method to use (other than in the manufacture of peptides) or detect such sequences specifically; (d)&nbsp;which are owned by, licensed to or otherwise controlled by ROCHE or
its Affiliate, with rights to license or sublicense; and (e)&nbsp;with respect to which ROCHE has the right to grant the option provided for in Section&nbsp;2.5 of this Agreement. For purposes of
this Agreement, an invention will be deemed to have been conceived if there is a patent, patent application, written invention disclosure statement or other tangible document (whether or not
witnessed) describing such invention. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.32&nbsp;"ROCHE
Non-HCV/HIV Analyte Patent Rights" means any and all Valid Claims of U.S. and foreign patents and patent applications: (a)&nbsp;which claim
any nucleic acid sequence(s) or transmissible disease-causing agent(s), other than HCV or HIV; (b)&nbsp;which is a blood borne, infectious disease or virus to the extent such Valid Claims cover the
detection of any nucleic acid sequence(s) or transmissible disease-causing agent(s) of such infectious disease or virus; (c)&nbsp;which are owned by, licensed to or otherwise controlled by ROCHE or
its Affiliates, with right to license or sublicense; and (d)&nbsp;with respect to which ROCHE has the right to grant the option provided for in Section&nbsp;2.5 of this Agreement. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.33&nbsp;"ROCHE
Optioned Patents" means: (a)&nbsp;the patents and applications identified in Exhibit&nbsp;C and any continuation,
continuation-in-part and divisional applications therefrom; (b)&nbsp;any reissued or reexamined
patents obtained from such patents and applications; (c)&nbsp;all foreign counterparts of such patents and applications; and (d)&nbsp;all future patents and applications which are based on
inventions conceived by ROCHE or its Affiliates on or before the Effective Date, to the extent the items described in clauses (a)&nbsp;through (d)&nbsp;of this Section&nbsp;1.33 contain a Valid
Claim Directed to HIV which covers the manufacture, use, sale, offer for sale or importation of a product in the Field or in Transplantation. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.34&nbsp;"ROCHE
Optioned Product" means a Product which is manufactured, used, offered for sale, imported or sold under circumstances which would, in the absence of the
license for which an option is </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>6</FONT></P>

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<P><FONT SIZE=2>
granted under Section&nbsp;2.3, constitute an infringement of a Valid Claim of the ROCHE Optioned Patents. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.35&nbsp;"ROCHE
Optioned Rights" means the ROCHE Future HIV Sequence Patent Rights and the ROCHE Non-HCV/HIV Analyte Patent Rights. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.36&nbsp;"Transplantation"
means the commercial use of products that detect nucleic acid sequences for the screening of any biological materials intended for transfusion or
transplantation, in each case from any donor, including autologous donors, other than the transfusion or transplantation of blood or its derivatives, components or replacements. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.37&nbsp;"Units"
means the number of individual donations of blood, plasma or other blood components that are tested for Blood Screening by End Users through the use of a
CHIRON Licensed Product. In the event that ROCHE or its Affiliates perform assays for commercial purposes utilizing CHIRON Licensed Product, Units shall include the number of individual donations of
blood, plasma or other blood components that are so tested by ROCHE or its Affiliates. Notwithstanding the foregoing, Units shall not include those CHIRON Licensed Products used by or for End Users at
no charge by ROCHE for (A)&nbsp;reasonable quantities of quality control or evaluation testing or (B)&nbsp;replacement of defective goods. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.38&nbsp;"Valid
Claim" means a claim in any issued, active, unexpired patent which has not been withdrawn, cancelled, lapsed or disclaimed, or held unpatentable, invalid or
permanently unenforceable by a non-appealed or nonappealable final decision by a court or other appropriate body of competent jurisdiction. The scope of a Valid Claim shall be limited to
its terms as defined by any such court or decision-making body of competent jurisdiction in a nonappealable or non-appealed final decision. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mc2030_article_2_license_and_option_grants"> </A>
<A NAME="toc_mc2030_4"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 2<BR>  LICENSE AND OPTION GRANTS    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.1&nbsp;</FONT><FONT
SIZE=2><I>CHIRON Grants.</I></FONT><FONT SIZE=2> Subject to the terms and conditions of this Agreement, CHIRON hereby grants to ROCHE and its
Affiliates, so long as they remain Affiliates of ROCHE, a worldwide, nonexclusive license, without the right to sublicense except to have made or to conduct research, under the CHIRON Licensed Patents
to research, develop, make, have made, import, use, offer for sale and sell CHIRON Licensed Products for use in the Field. CHIRON covenants not to sue any End User of a CHIRON Licensed Product (with
respect to which ROCHE has performed all of its material obligations under this Agreement) to the extent of activities in the Field or otherwise permitted under this Agreement. Conversely no immunity
from suit shall apply to End User activities in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics, except as provided in the HIV Diagnostics Agreement, or otherwise outside of the
Field. Subject to Paragraph&nbsp;4 of Exhibit&nbsp;A, CHIRON retains the nonexclusive right to practice and to grant licenses under the CHIRON Licensed Patents to make, have made, use, import,
offer for sale and sell any Products in the Field and all rights outside of the Field. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.2&nbsp;</FONT><FONT
SIZE=2><I>Exclusion from CHIRON License.</I></FONT><FONT SIZE=2> ROCHE acknowledges that neither ROCHE nor its Affiliates are licensed under this
Agreement to perform research or to develop any product other than a CHIRON Licensed Product. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.3&nbsp;</FONT><FONT
SIZE=2><I>ROCHE Optioned Patents.</I></FONT><FONT SIZE=2> Subject to the terms and conditions of this Agreement, ROCHE hereby grants to CHIRON and its
Affiliates, so long as they remain Affiliates of CHIRON, an option to enter into a worldwide, non-exclusive license, with no right to sublicense except to have made or to conduct research,
under ROCHE Optioned Patents to research, develop, make, have made, import, use, offer for sale and sell ROCHE Optioned Products for use in the Field and in Transplantation.
[**] </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.4&nbsp;</FONT><FONT
SIZE=2><I>CHIRON Optioned Rights.</I></FONT><FONT SIZE=2> CHIRON grants to ROCHE a nonexclusive option to obtain one or more nonexclusive, worldwide
licenses, or sublicenses, as the case may be, with a right to sublicense to ROCHE Affiliates only, under the CHIRON Optioned Rights, to make, have made, use, import, offer </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>7</FONT></P>

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<P><FONT SIZE=2>
for sale and sell CHIRON Licensed Products and/or products in the Field and in Transplantation (including as to CHIRON Non-HCV/HIV Analyte Patent Rights products for the detection of other
transmissible disease-causing agents). [**] </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.5&nbsp;</FONT><FONT
SIZE=2><I>ROCHE Optioned Rights.</I></FONT><FONT SIZE=2> ROCHE grants to CHIRON a nonexclusive option to obtain one or more nonexclusive, worldwide
licenses, or sublicenses, as the case may be, with a right to sublicense to CHIRON Affiliates only, under the ROCHE Optioned Rights, to make, have made, use, import, offer for sale and sell products
in the Field and in Transplantation (including as to ROCHE Non-HCV/HIV Analyte Patent Rights products for the detection of other transmissible disease-causing agents).
[**] </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.6&nbsp;</FONT><FONT
SIZE=2><I>Option Terms.</I></FONT><FONT SIZE=2> As to any Valid Claim(s) included within CHIRON Optioned Rights or ROCHE Optioned Rights, the options
set forth in Sections 2.4 and 2.5 may be exercised at any time [**] during the life of such patent(s), by written notice from the option grantee to the option grantor
identifying the patent(s) under which the grantee wishes to obtain a license; [**] The terms of such license agreement will be subject to the following: </FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;[**]
</FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;[**] </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;[**] </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;The
licensee will be able to terminate the license agreement at any time by giving the licensor prior written notice; </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;The
licensee will not have any right of enforcement, and will not receive from the licensor any warranty of validity or noninfringement; provided, however, the
licensor shall disclose to the licensee prior to entering into such license, any knowledge it has of any pending or written threatened claim that is material to any challenge of validity or
enforceability, except to the extent that such disclosure is subject to an obligation of confidentiality, protective order or legal privilege; and </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;&nbsp;[**] </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.7&nbsp;</FONT><FONT
SIZE=2><I>Need for Option.</I></FONT><FONT SIZE=2> CHIRON may, at any time hereunder, provide written notification to ROCHE that certain products
being sold or used by ROCHE are believed by CHIRON to be covered by one or more Valid Claims of a patent included within CHIRON Optioned Rights not licensed to ROCHE. In the event ROCHE does not,
[**] of receipt of such notification, exercise the relevant option provided for under Section&nbsp;2.4 to obtain a license under such CHIRON Optioned Right, then CHIRON and
ROCHE shall promptly thereafter confer in good faith to discuss their respective positions concerning whether such products being sold or used by ROCHE are covered by a Valid Claim of the patent in
question. [**] within ninety (90)&nbsp;days following the above-mentioned notification, [**]. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.8&nbsp;</FONT><FONT
SIZE=2><I>Option Exercise.</I></FONT><FONT SIZE=2> [**] </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.9&nbsp;</FONT><FONT
SIZE=2><I>Effect on Option by Termination.</I></FONT><FONT SIZE=2> Termination of this Agreement pursuant to Article&nbsp;7 shall terminate the
provisions of Sections 2.3 to 2.9; provided, however, that if at the time of such termination or, if prior notification is required under Section&nbsp;7.3, then if immediately prior to the effective
date of termination set forth in such notification: (a)&nbsp;a license agreement arising out of the options granted under Section&nbsp;2.3, 2.4 or 2.5 is in effect, such license shall survive such
termination under Article&nbsp;7 and shall remain in effect in accordance with its terms; or (b)&nbsp;a party has properly exercised an option pursuant to Section&nbsp;2.3, 2.4 or 2.5 and is
proceeding in good faith to negotiate a license agreement thereunder, the parties shall complete such negotiations in good faith. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.10&nbsp;</FONT><FONT
SIZE=2><I>Third Party Patents.</I></FONT><FONT SIZE=2> Each party shall use reasonable commercial efforts to acquire the right to grant the options
provided in Sections 2.4 and 2.5 when it acquires rights under patents of third parties. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>8</FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mc2030_article_3_payments,_royalties"> </A>
<A NAME="toc_mc2030_5"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 3<BR>  PAYMENTS, ROYALTIES    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;With respect to all Units, ROCHE shall make payments to CHIRON as set forth in Exhibit&nbsp;A. For the avoidance of doubt, payments are due CHIRON only with
respect to [**] </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mc2030_article_4_records_and_reports"> </A>
<A NAME="toc_mc2030_6"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 4<BR>  RECORDS AND REPORTS    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;4.1&nbsp;</FONT><FONT
SIZE=2><I>Units Data.</I></FONT><FONT SIZE=2> ROCHE shall use commercially reasonable efforts to collect Units data for each Calendar Quarter from End
Users in such detail and accuracy so as to enable a determination of the amounts payable by ROCHE to CHIRON hereunder. In the event an End User fails to timely report its Units data for a Calendar
Quarter to ROCHE, ROCHE shall include in the report for such Calendar Quarter required under Section&nbsp;4.3 a reasonable estimate of the number of such Units, subject to a "true up" correction in
the subsequent Calendar Quarter. [**]. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;4.2&nbsp;</FONT><FONT
SIZE=2><I>Earned Royalty Report.</I></FONT><FONT SIZE=2> ROCHE shall, within ninety (90)&nbsp;days after the last day of each Calendar Quarter
commencing on or after [**], deliver to CHIRON a true and accurate report for the prior Calendar Quarter, substantially in the form attached as Exhibit&nbsp;E to this
Agreement, which shall state the amount of monies due hereunder, if any, as Earned Royalties, and shall include all information reasonably necessary to calculate such amount, including, but not
limited to, the following information, presented by Region and by Product and Field Category (as defined in Paragraph&nbsp;1 of Exhibit&nbsp;A): </FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;the
number of Units and the applicable Earned Royalty Amounts, together with any "true-up" adjustments to (i)&nbsp;Units from prior Calendar Quarters
(e.g., late reporting End Users) or (ii)&nbsp;the estimate of Earned Royalties paid pursuant to Section&nbsp;4.3; and </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;a
statement of the basis for any deviation from the Earned Royalty rates and Earned Royalty Amounts as expressed in Paragraphs 1 and 2 of Exhibit&nbsp;A. </FONT></P>

<P><FONT SIZE=2>Upon
written request by CHIRON, ROCHE will annotate and redeliver to CHIRON any Earned Royalty Report four (4)&nbsp;or more Calendar Quarters old to include Units and Earned Royalty Amounts on a
country-by-country basis. Notwithstanding the above, ROCHE shall deliver to CHIRON the Earned Royalty Report for the Calendar Quarter ending [**] not
later than [**]. </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;4.3&nbsp;</FONT><FONT
SIZE=2><I>Payment Dates.</I></FONT><FONT SIZE=2> Not later than seventy-five (75)&nbsp;days after the last day of each Calendar Quarter
commencing on or after [**], ROCHE shall pay to CHIRON a good faith estimate of the Earned Royalty for such Calendar Quarter due under this Agreement. Such good faith estimate
shall be based on the most recent Units data available to ROCHE, together with such reasonable growth and seasonality assumptions utilized by ROCHE for external planning purposes. If no Earned
Royalties are due, ROCHE shall so report, stating the reasons why no such royalty is due. Not later than the date each Earned Royalty Report required under Section&nbsp;4.2 is due, ROCHE shall
"true-up" its estimated Earned Royalty payment based on the number of Units set forth in the Earned Royalty Report for such Calendar Quarter and, if it is determined that the estimate of
Earned Royalties paid was less than the amount actually due for such Calendar Quarter, pay the underpaid amount, plus interest at the rate described in Section&nbsp;4.9. If it is determined that the
estimate of Earned Royalties paid was more than the amount actually due for such Calendar Quarter, such overpaid amount shall be credited against Earned Royalties payable on Units in the subsequent
Calendar Quarter, plus interest at the rate described in Section&nbsp;4.9. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>9</FONT></P>

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<P><FONT SIZE=2>
&nbsp;&nbsp;&nbsp;&nbsp;4.4&nbsp;</FONT><FONT SIZE=2><I>Payment Procedures.</I></FONT><FONT SIZE=2> ROCHE shall pay royalties and all other payments due hereunder to CHIRON in immediately
available funds on the due date by wire transfer to: </FONT></P>

<UL>
<UL>

<P><FONT SIZE=2>Bank
of America-San Francisco<BR>
San Francisco, California<BR>
Account Name: Chiron Corporation<BR>
Account Number: [**]<BR>
ABA #: [**]<BR>
Reference: ROCHE Blood Screening HIV Probe License Agreement </FONT></P>

</UL>
</UL>

<P><FONT SIZE=2>or
at such place and in such other manner as CHIRON may designate in a notice signed by CHIRON's Treasurer or Controller to ROCHE. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;4.5&nbsp;</FONT><FONT
SIZE=2><I>Taxes on Royalties.</I></FONT><FONT SIZE=2> ROCHE shall deduct from amounts payable hereunder all taxes assessed or imposed against, or
required to be withheld from, royalty payments due and shall pay such amount to the appropriate fiscal or tax authorities on behalf of CHIRON. ROCHE shall forward promptly to CHIRON all tax receipts
received by ROCHE evidencing payment of such taxes. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;4.6&nbsp;</FONT><FONT
SIZE=2><I>Audit Rights.</I></FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;</FONT><FONT
SIZE=2><I>End Users.</I></FONT><FONT SIZE=2> ROCHE shall use commercially reasonable efforts to include sufficient audit rights in all agreements with
End Users of CHIRON Licensed Products to enable ROCHE to confirm the validity of such End Users' periodic Units data. Upon thirty (30)&nbsp;days written notice by CHIRON, not more frequently than
once per Calendar Year and either in conjunction with an audit permitted under Section&nbsp;4.6(c) or not within the same Calendar Year as such an audit, CHIRON may have such End User agreements
examined during reasonable business hours by a mutually acceptable independent certified public accountant selected by CHIRON and at CHIRON's expense, whose acceptance shall not unreasonably be
withheld by ROCHE, for the purpose of verifying the existence of such audit rights; provided that such independent accountant agrees to provide CHIRON only the information necessary to verify the
existence of such audit rights without the disclosure of any End User identity; and provided further, that ROCHE may propose an alternative methodology of confirming to CHIRON the validity of such End
Users' periodic Units data, subject to CHIRON's prior written consent, which may not be unreasonably withheld. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;</FONT><FONT
SIZE=2><I>Existing End Users.</I></FONT><FONT SIZE=2> Within thirty (30)&nbsp;days of the Effective Date or as soon as possible thereafter, CHIRON
shall have all End User agreements examined during reasonable business hours by a mutually acceptable independent certified public accountant selected by CHIRON and at CHIRON's expense, whose
acceptance shall not unreasonably be withheld by ROCHE, for the purpose of preparing and verifying a schedule of Existing End Users sufficient to determine the basis upon which Earned Royalties shall
be calculated in accordance with Exhibit&nbsp;A for each of the Calendar Quarters in the Calendar Year ending December&nbsp;31, 2001; provided that such independent accountant agrees to provide
CHIRON only the information necessary to verify the calculation of such Earned Royalties without the disclosure of any End User identity or contractual terms. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Earned
Royalties. ROCHE shall keep reasonably detailed and accurate records and books of account, including without limitation retaining all End User Units data and
End User audit materials, to enable a determination of the amounts payable by ROCHE and its Affiliates to CHIRON hereunder. Upon thirty (30)&nbsp;days written notice by CHIRON, not more frequently
than once per Calendar Year and either in conjunction with an audit permitted under Section&nbsp;4.6(a) or not within the same Calendar Year as such an audit, CHIRON may have such records and books
of account examined during reasonable business hours by a mutually acceptable independent certified public accountant selected by CHIRON and at CHIRON's expense, whose acceptance </FONT></P>

</UL>
<P ALIGN="CENTER"><FONT SIZE=2>10</FONT></P>

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<UL>

<P><FONT SIZE=2>
shall not unreasonably be withheld by ROCHE, for the purpose of verifying the amounts due hereunder; provided that such independent accountant agrees to provide CHIRON only the information necessary
to verify the calculation of amounts due hereunder. A copy of any final written report provided by the independent accountant to CHIRON shall be given concurrently to ROCHE. Such examination shall not
be permitted unless it is requested within three (3)&nbsp;years following the end of the Calendar Year to which the books and records pertain. Where such examination results in a finding that ROCHE
underpaid CHIRON by the greater of [**] or [**] over any one year period, ROCHE shall reimburse CHIRON for its reasonable costs and expenses in
conducting such examination. ROCHE and CHIRON shall promptly rectify any overpayments or underpayments by repaying such amounts together with interest thereon at an annual rate equal to the lesser of:
(a)&nbsp;[**] as published in the Wall Street Journal, or (b)&nbsp;the maximum rates permitted by applicable law, from the time such payment was originally due to the time
it is paid. </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;4.7&nbsp;</FONT><FONT
SIZE=2><I>Confidentiality of Audit.</I></FONT><FONT SIZE=2> CHIRON agrees that all audited information shall be confidential to ROCHE and its
Affiliates, and that any person or entity conducting an audit on behalf of CHIRON pursuant to Section&nbsp;4.6 shall be required to protect the confidentiality of such information. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;4.8&nbsp;</FONT><FONT
SIZE=2><I>Payment in United States Currency.</I></FONT><FONT SIZE=2> All payments shall be made in United States Dollars and shall be made on the
dates set forth herein. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;4.9&nbsp;</FONT><FONT
SIZE=2><I>Late Payment Fee.</I></FONT><FONT SIZE=2> Any payment, including, without limitation, royalty payments, made by ROCHE hereunder after the
date such payment is due, as set forth in this Article&nbsp;4 hereof, shall bear interest at the lesser of: (a)&nbsp;[**] as published in the Wall Street Journal as of the
date such payment was due, or (b)&nbsp;the maximum rate permitted by applicable law. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>11</FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="md2030_article_5_other_actions"> </A>
<A NAME="toc_md2030_1"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 5<BR>  OTHER ACTIONS    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;5.1&nbsp;</FONT><FONT
SIZE=2><I>Patent Validity; Enforceability.</I></FONT><FONT SIZE=2> Immediately upon the Effective Date, or as soon as possible thereafter, ROCHE shall
discontinue any opposition, challenge, compulsory license application or the like with respect to the CHIRON Licensed Patents. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;5.2&nbsp;</FONT><FONT
SIZE=2><I>Compulsory Licensing.</I></FONT><FONT SIZE=2> ROCHE covenants and agrees on behalf of itself and its Affiliates to not support any third
party in seeking compulsory licensing of the CHIRON Licensed Patents in any jurisdiction. As used in this Section, "support" shall have the same meanings as in Section&nbsp;7.2(b). </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="md2030_article_6_representations_and_warranties"> </A>
<A NAME="toc_md2030_2"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 6<BR>  REPRESENTATIONS AND WARRANTIES    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;6.1&nbsp;</FONT><FONT
SIZE=2><I>Corporate Authority.</I></FONT><FONT SIZE=2> Each party represents and warrants to the other party that it has the necessary corporate
authority to enter into this Agreement. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;6.2&nbsp;</FONT><FONT
SIZE=2><I>Right to Grant.</I></FONT><FONT SIZE=2> Each party represents and warrants that they have the right to grant the licenses and options
granted in Article&nbsp;2 hereof and that they are the sole owner of their respective Licensed/Optioned Patents, subject to licenses existing as of the Effective Date. CHIRON represents and warrants
to ROCHE that, to the best of its knowledge, neither CHIRON nor any of its Affiliates have transferred to [**] or any if its Affiliates (a)&nbsp;before December&nbsp;1,
1998, title to any patent or patent application Directed to HIV in the Field existing on that date; or (b)&nbsp;on or after that date, title to any patent, patent application or invention Directed
to HIV in the Field. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;6.3&nbsp;</FONT><FONT
SIZE=2><I>Current Licenses.</I></FONT><FONT SIZE=2> CHIRON represents and warrants that: (a)&nbsp;as of the Effective Date the entities set forth in
Exhibit&nbsp;F are the only parties to which it has granted any licensed rights or other grants or immunities to one or more of the CHIRON Licensed Patents in the Field; and
(b)&nbsp;Exhibit&nbsp;F contains a
complete and accurate description of the effective scope, field and territory of such grant as of the Effective Date. CHIRON also represents and warrants that [**] except as
disclosed in Exhibit&nbsp;F. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;6.4&nbsp;</FONT><FONT
SIZE=2><I>Complete Patent List.</I></FONT><FONT SIZE=2> CHIRON represents and warrants to ROCHE that, to the best of its knowledge and belief,
Exhibit&nbsp;B contains a complete list, as of the Effective Date, of all patents and patent applications owned by, licensed to (with a right to sublicense), or otherwise controlled by CHIRON or its
Affiliates containing claims Directed to HIV in the Field. To the extent that any other patent or patent application owned by, licensed to (with a right to sublicense) or otherwise controlled by
CHIRON or its Affiliates and filed on or before the Effective Date contains a claim Directed to HIV in the Field, such patent or patent application shall be automatically added to the CHIRON Licensed
Patents. Upon ROCHE's written request, not more frequently than annually, CHIRON shall provide ROCHE with an updated Exhibit&nbsp;B and a report of the prosecution status of applications within
CHIRON Licensed Patents. ROCHE represents and warrants to CHIRON that, to the best of its knowledge and belief, Exhibit&nbsp;C contains a complete list, as of the Effective Date, of all patents and
patent applications owned by, licensed to (with a right to sublicense), or otherwise controlled by ROCHE or its Affiliates containing claims Directed to HIV in the Field. To the extent that any other
patent or patent application owned by, licensed to (with a right to sublicense) or otherwise controlled by ROCHE or its Affiliates and filed on or before the Effective Date contains a claim Directed
to HIV in the Field, such patent or patent application shall be automatically added to the ROCHE Optioned Patents. Upon CHIRON's written request, not more frequently than annually, ROCHE shall provide
CHIRON with an updated Exhibit&nbsp;C and a report of the prosecution status of applications within ROCHE Optioned Patents. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;6.5&nbsp;</FONT><FONT
SIZE=2><I>Exclusions.</I></FONT><FONT SIZE=2> Nothing contained in this Agreement shall be construed as: </FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;A
representation or warranty by any party hereto as to the validity of any patent rights which are the subject of this Agreement; </FONT></P>

</UL>
<P ALIGN="CENTER"><FONT SIZE=2>12</FONT></P>

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<UL>

<P><FONT SIZE=2>
&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;A representation or warranty that anything made, used, imported, offered for sale, sold or otherwise disposed of under any of the patent rights which are the
subject of this Agreement is or will be free from infringement of patents of third parties or of patents of either party that are not Directed to HIV; </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;An
obligation to bring or prosecute actions or suits against third parties for infringement of any patent rights which are the subject of this Agreement; </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;A
grant of any right to bring or prosecute actions or suits against third parties for infringement of any patent rights which are the subject of this Agreement; or </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;A
grant, by implication, estoppel or otherwise, of any license, option, covenant or right other than those which are expressly stated herein, including without
limitation (i)&nbsp;any license under any patent or patent application (or claim thereof) not within the Licensed/Optioned Patents, or (ii)&nbsp;any covenant by CHIRON or ROCHE not to sue under
any such patent or patent application (or claim thereof). </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;6.6&nbsp;</FONT><FONT
SIZE=2><I>Further ROCHE Assurance.</I></FONT><FONT SIZE=2> ROCHE acknowledges that the inclusion of ROCHE Affiliates within the license and option
grants pursuant to Sections 2.1 and 2.4 is intended to enable ROCHE to utilize the manufacturing and sales capabilities of its Affiliates in connection with the manufacture and sale of CHIRON Licensed
Products in a manner substantially similar to the involvement of such Affiliates in the manufacture and sale of ROCHE's products generally. ROCHE shall not, directly or indirectly, take any action
having or intended to have the effect of sublicensing ROCHE's rights under any of the CHIRON Licensed Patents, other than to a </FONT><FONT SIZE=2><I>bona fide</I></FONT><FONT SIZE=2> Affiliate,
including, without limitation, by creating Affiliates specifically in connection with CHIRON Licensed Products, or through other third party arrangements such as joint ventures, collaborations, or
distribution arrangements with distributors. ROCHE and its Affiliates are licensed hereunder to sell and distribute CHIRON Licensed Products only under the label, name and trademark rights owned by,
licensed to or otherwise controlled by ROCHE or its Affiliates, and only through the sales force of ROCHE or its Affiliates, or through Authorized Distributors. ROCHE and its Affiliates are not
licensed to perform OEM manufacturing of CHIRON Licensed Products for a third party other than an Authorized Distributor; to supply CHIRON Licensed Products for resale to any third party other than an
Authorized Distributor; to permit any Authorized Distributor or other third party to sell any CHIRON Licensed Products under another third party label, name or trademark or to permit any Authorized
Distributor or other third party to sell any CHIRON Licensed Products under the Authorized Distributor's or any third party's own label, name or trademark for use on an instrument bearing the label
name or trademark of a party other than ROCHE or its Affiliates; provided, however, that nothing in this Section&nbsp;6.6 shall be construed to limit the rights of ROCHE or its Affiliates to engage
in activities with such third parties, to the extent such third parties have obtained rights under the CHIRON Licensed Patents permitting such activities. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;6.7&nbsp;</FONT><FONT
SIZE=2><I>Limitation of Warranty.</I></FONT><FONT SIZE=2> EXCEPT AS SPECIFICALLY SET FORTH HEREIN, NO PARTY MAKES ANY REPRESENTATION OR WARRANTY,
EITHER EXPRESS OR IMPLIED, ARISING BY LAW OR OTHERWISE, INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="md2030_article_7_term_and_termination"> </A>
<A NAME="toc_md2030_3"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 7<BR>  TERM AND TERMINATION    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;7.1&nbsp;</FONT><FONT
SIZE=2><I>Term.</I></FONT><FONT SIZE=2> This Agreement shall be in effect from the Effective Date until the last to expire of the CHIRON Licensed
Patents issued under the authority of the Patent and Trademark Office of the United States (the "Term"), unless earlier terminated pursuant to Sections 7.2 or 7.3 below. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>13</FONT></P>

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<P><FONT SIZE=2>
&nbsp;&nbsp;&nbsp;&nbsp;7.2&nbsp;</FONT><FONT SIZE=2><I>Voluntary Termination.</I></FONT><FONT SIZE=2> ROCHE may voluntarily terminate all, but not less than all, licenses granted to ROCHE and its
Affiliates under this Agreement on a country-by-country basis, on not less than six (6)&nbsp;months prior written notice to CHIRON. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;7.3&nbsp;Termination
by CHIRON. CHIRON may terminate this Agreement only upon any of the following grounds: </FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;ROCHE's
or its Affiliate's material breach of this Agreement, including, without limitation, a breach resulting from ROCHE's or its Affiliate's failure to pay any
sums due hereunder, where such breach shall not have been remedied within thirty (30)&nbsp;days of the receipt of a written notification from CHIRON identifying the breach and requiring its remedy;
whereupon termination under this Section&nbsp;7.3(a) shall be effective upon the expiration of such thirty (30)&nbsp;day cure period, subject to Section&nbsp;7.6; or </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;[**] </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;7.4&nbsp;</FONT><FONT
SIZE=2><I>Enforcement After Termination.</I></FONT><FONT SIZE=2> Upon valid termination of this Agreement under Section&nbsp;7.2 or 7.3, ROCHE and
its Affiliates shall have no further rights under CHIRON Licensed Patents and CHIRON shall not be limited to its remedies under this Agreement, to the extent of such termination. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;7.5&nbsp;</FONT><FONT
SIZE=2><I>Accrued Rights.</I></FONT><FONT SIZE=2> Termination of this Agreement for whatever reason shall not affect any rights which have accrued
prior to termination, including without limitation royalty obligations occurring during the Term, calculated in accordance with Article&nbsp;3 and Exhibit&nbsp;A. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;7.6&nbsp;</FONT><FONT
SIZE=2><I>ROCHE Challenge to Section&nbsp;7.3(a) Termination.</I></FONT><FONT SIZE=2> In the event ROCHE provides written notification to CHIRON
prior to expiration of the thirty (30)&nbsp;day notice/cure period referenced in Section&nbsp;7.3(a) that ROCHE disputes whether the grounds for termination under Section&nbsp;7.3(a) are
present, such dispute shall be submitted to ADR pursuant to Article&nbsp;10. The thirty (30)&nbsp;day notice/cure period shall be suspended during the pendancy of such ADR, provided that during
the pendancy of the ADR, ROCHE shall continue to make any disputed payments to CHIRON, on the condition that CHIRON shall repay ROCHE the amounts of such disputed payments if ROCHE prevails in the
ADR, plus interest at the rate described in Section&nbsp;4.9. Notwithstanding anything in this Section&nbsp;7.6 to the contrary, ROCHE may submit a dispute concerning a method by which amounts
payable by ROCHE and its Affiliates to CHIRON hereunder are calculated only one time, and any resolution from the ADR shall bind the parties as to such calculation method thereafter. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;7.7&nbsp;</FONT><FONT
SIZE=2><I>ROCHE Challenge to Section&nbsp;7.3(b) Termination.</I></FONT><FONT SIZE=2> In the event that ROCHE, within thirty (30)&nbsp;days of
receiving notice of termination by CHIRON for the grounds set forth in Section&nbsp;7.3(b) above, provides written notice to CHIRON that ROCHE disputes whether such grounds are present, such dispute
shall be submitted to ADR pursuant to Article&nbsp;10 and termination of this Agreement shall be suspended during the pendancy of the ADR, provided that ROCHE suspends its action, suit or proceeding
(other than in an ADR proceeding between the parties as permitted by Section&nbsp;7.3 (b)&nbsp;and Article&nbsp;10) [**] and continues to perform all of its material
obligations hereunder. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;7.8&nbsp;</FONT><FONT
SIZE=2><I>Audit Results Not Grounds for Termination.</I></FONT><FONT SIZE=2> CHIRON's request for an audit under Section&nbsp;4.6 shall not be
treated as a notice of breach under Section&nbsp;7.3(a). In the event such audit determines there has been an underpayment by ROCHE, such underpayment shall not constitute grounds for termination by
CHIRON under Section&nbsp;7.3(a) unless: (a)&nbsp;ROCHE has failed to rectify such underpayment in accordance with Section&nbsp;4.6; (b)&nbsp;ROCHE has failed to rectify such underpayment
after notification and opportunity to cure under Section&nbsp;7.3(a); and (c)&nbsp;any ADR requested by ROCHE, pursuant to Section&nbsp;7.6, and directed to any dispute concerning such
underpayment, results in a determination favorable to CHIRON and ROCHE has failed to rectify such underpayment. Notwithstanding the foregoing, ROCHE shall continue to make the disputed payments to
CHIRON, on the condition that CHIRON shall repay ROCHE the amounts of such disputed payments with respect to which ROCHE prevails in the ADR, plus interest at the rate described in Section&nbsp;4.9. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>14</FONT></P>

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<P><FONT SIZE=2>
&nbsp;&nbsp;&nbsp;&nbsp;7.9&nbsp;</FONT><FONT SIZE=2><I>Survival.</I></FONT><FONT SIZE=2> The following provisions of this Agreement shall survive termination or expiration of this Agreement, in
accordance with their respective terms: Article&nbsp;1; Sections 4.6, 4.7, 4.8, 4.9, 6.7, 7.4, 7.5 and 7.9; Articles 8, 9, and 10; Sections 11.9 through 11.14; and Section&nbsp;14.1. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="md2030_article_8_confidentiality"> </A>
<A NAME="toc_md2030_4"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 8<BR>  CONFIDENTIALITY    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;8.1&nbsp;</FONT><FONT
SIZE=2><I>Obligation.</I></FONT><FONT SIZE=2> From time to time during the Term, CHIRON and ROCHE may provide to each other information concerning
patents, patent applications, license agreements and other confidential or proprietary information related to this Agreement (the "Information"). Notwithstanding anything in this Agreement to the
contrary, following the execution of this Agreement, Earned Royalty Amounts payable under this Agreement shall be deemed "Information" as to which both CHIRON and ROCHE shall be deemed to be the party
receiving the Information (the "Receiving Party"). Each Receiving Party shall during the Term and for a period of three (3)&nbsp;years after termination hereof: (a)&nbsp;maintain the Information
in confidence; (b)&nbsp;not disclose the Information to any third party, other than employees, agents or consultants of the Receiving Party, its Affiliates or permitted sublicensees who have a need
to
know the Information and who are bound by confidentiality obligations to the Receiving Party no less restrictive than those contained herein; and (c)&nbsp;not use the Information for any purpose not
directly related to performance hereunder or otherwise authorized under this Agreement. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;8.2&nbsp;</FONT><FONT
SIZE=2><I>Exclusions.</I></FONT><FONT SIZE=2> The obligations of this Article&nbsp;8 shall not apply to any Information which: (a)&nbsp;is or
which becomes generally known to the public by publication or by means other than a breach of a duty by the Receiving Party; (b)&nbsp;is otherwise known by the Receiving Party at the time of
disclosure by the other party; (c)&nbsp;otherwise becomes available to the Receiving Party from a third party not in breach of confidentiality obligations to the other party; or (d)&nbsp;is
developed by or for the Receiving Party independent of any disclosure from the other party. The Receiving Party also shall be permitted to make disclosures of Information which are reasonably
necessary in connection with a possible grant of a permitted sublicense by the Receiving Party or in due diligence related to a possible acquisition, merger, consolidation, substantial asset transfer
or similar transaction of the Receiving Party, provided that the recipient is bound to the Receiving Party by confidentiality obligations with respect to the Information no less restrictive than those
contained herein. Nothing herein shall prevent the Receiving Party from making such disclosures of Information as are reasonably required by law, regulation (including 37 C.F.R. &sect; 1.56),
or order of any court or governmental agency; provided that the Receiving Party has provided reasonable advance notice to allow the disclosing party the opportunity to seek a protective order or
otherwise contest, prevent or limit such disclosure. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;8.3&nbsp;</FONT><FONT
SIZE=2><I>Return of Information.</I></FONT><FONT SIZE=2> Upon termination of this Agreement for any reason, the Receiving Party shall return, or at
the option of the disclosing party, certify destruction of, all Information and copies thereof; provided that the Receiving Party may retain one copy thereof in its law department files solely for
evidentiary and regulatory purposes. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;8.4&nbsp;</FONT><FONT
SIZE=2><I>Disclosure of Agreements and Terms.</I></FONT><FONT SIZE=2> Each of the parties may issue a press release disclosing the existence of this
Agreement. Subject to mutual agreement as to form and substance, the parties may make selected disclosure of the material financial terms in such press releases. Each party may disclose any of the
terms of this Agreement to any Affiliate; provided that the recipient of such disclosure is obligated to confidentiality terms no less restrictive than those contained in this Article&nbsp;8. Each
party may disclose any information contained in or regarding this Agreement to the extent required in its respective reasonable judgment by applicable law, regulation or order of any court or
governmental agency. Further, each party may determine in its respective discretion to file this Agreement under the Securities and Exchange Act of 1934 or otherwise with any United States or foreign
governmental agency, even if that filing may result in this Agreement becoming available to the public generally. The filing party shall seek confidential treatment for at least the essential
financial terms hereof in connection with any such filing, subject to applicable law and regulation, and shall </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>15</FONT></P>

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<P><FONT SIZE=2>
notify the other party in advance of any such filing and consider such suggestions as the other party may make as to the terms herein as to which the filing party should seek confidential treatment. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="md2030_article_9_indemnity"> </A>
<A NAME="toc_md2030_5"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 9<BR>  INDEMNITY    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;9.1&nbsp;</FONT><FONT
SIZE=2><I>ROCHE Indemnity.</I></FONT><FONT SIZE=2> ROCHE shall indemnify, defend and hold harmless CHIRON and its Affiliates and their officers,
directors, shareholders, employees, representatives and agents, against any claim, demand, loss, damage or injury, including reasonable attorneys' fees, asserted by a third party, arising from,
relating to, or otherwise in respect of, (a)&nbsp;the manufacture, use or sale of CHIRON Licensed Products, or (b)&nbsp;any breach by ROCHE or its Affiliates of any representation, warranty or
covenant under this Agreement; provided, however, that such indemnity shall not extend to damages arising directly from any breach or willful or negligent act of CHIRON or its Affiliates. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;9.2&nbsp;</FONT><FONT
SIZE=2><I>CHIRON Indemnity.</I></FONT><FONT SIZE=2> CHIRON shall indemnify, defend and hold harmless ROCHE and its Affiliates and their officers,
directors, shareholders, employees, representatives and agents, against any claim, demand, loss, damage or injury, including reasonable attorneys' fees, asserted by a third party, arising from,
relating to, or otherwise in respect of, (a)&nbsp;the manufacture, use or sale of ROCHE Optioned Products, or (b)&nbsp;any breach by CHIRON or its Affiliates of any representation, warranty or
covenant under this Agreement; provided, however, that such indemnity shall not extend to damages arising directly from any breach or willful or negligent act of ROCHE or its Affiliates. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;9.3&nbsp;</FONT><FONT
SIZE=2><I>Indemnification Procedures.</I></FONT><FONT SIZE=2> In the event either party claims indemnification pursuant to this Article&nbsp;9, the
indemnified party shall promptly notify the indemnifying party in writing upon becoming aware of any claim to which such indemnification may apply. Delay in providing such notice shall constitute a
waiver of the indemnifying party's indemnity obligations hereunder only if the indemnifying party's ability to defend such claim is materially impaired thereby. The indemnifying party shall have the
right to assume and solely control the defense of the claim at its own expense. If the right to assume and solely control the defense is exercised, the indemnified party shall have the right to
participate in, but not to control, such defense at its own expense, and the indemnifying party's indemnity obligations shall be deemed not to include attorneys' fees and litigation expenses incurred
by the indemnified party after the assumption of the defense by the indemnifying party. If the indemnifying party does not assume the defense of the claim, the indemnified party may defend the claim
at the indemnifying party's expense. The indemnified party shall not settle or compromise the claim without the prior written consent of the indemnifying party, and the indemnifying party shall not
settle or compromise the claim in any manner which would have an adverse effect on the indemnified party without the consent of the indemnified party, which consent, in each case, shall not be
unreasonably withheld. The indemnified party shall reasonably cooperate with the indemnifying party and shall make available to the indemnifying party all pertinent information under the control of
the indemnified party, all at the expense of the indemnifying party. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;9.4&nbsp;</FONT><FONT
SIZE=2><I>Sunset.</I></FONT><FONT SIZE=2> The provisions of Sections 9.1 and 9.2 shall continue in effect on a claim-by-claim
basis, after the termination of this Agreement, only until the expiration of the last to expire statute of limitations applicable to such claim. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;9.5&nbsp;</FONT><FONT
SIZE=2><I>Limitation of Liability.</I></FONT><FONT SIZE=2> Neither party shall be liable to the other for any consequential, special, indirect or
exemplary damages or for the loss of profits arising from the performance or nonperformance of this Agreement or any acts or omissions associated herewith. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="md2030_article_10_alternative_dispute_resolution"> </A>
<A NAME="toc_md2030_6"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 10<BR>  ALTERNATIVE DISPUTE RESOLUTION    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The parties recognize that </FONT><FONT SIZE=2><I>bona-fide</I></FONT><FONT SIZE=2> disputes may from time to time arise which relate to any
aspect of this Agreement, including, without limitation, any of the parties' rights and/or obligations </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>16</FONT></P>

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<P><FONT SIZE=2>
hereunder, and including, without limitation, disputes relating to the interpretation, form, validity, performance and/or termination of this Agreement or relating to infringement, scope, claims
construction, or (without limiting the effect of Section&nbsp;7.3(b)) validity or enforceability of the CHIRON Licensed Patents. In the event of the occurrence of any dispute, a party may, by notice
to the other party, have such dispute referred to their respective employees designated below or their successors, for attempted resolution by good faith negotiations within ninety (90)&nbsp;days
after such notice is received. Said designated officers are as follows: </FONT></P>

<UL>
<UL>

<P><FONT SIZE=2>For
ROCHE:<BR></FONT> <FONT SIZE=2><B>President<BR>
Roche Molecular Systems,&nbsp;Inc.</B></FONT></P>

<P><FONT SIZE=2>For
CHIRON:<BR></FONT> <FONT SIZE=2><B>President<BR>
Blood Testing  </B></FONT></P>

</UL>
</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;In the event the designated officers, after such good faith negotiations, are not able to resolve such dispute within such ninety (90)&nbsp;day period, or
any agreed extension thereof, a party may invoke the provisions for binding ADR as set forth in Paragraph&nbsp;9 of the Settlement Agreement. Neither party shall seek recourse against the other
hereunder in any court or other forum, except as permitted by Paragraph&nbsp;9 of the Settlement Agreement or as may be necessary to enforce a determination made in ADR pursuant to this
Article&nbsp;10 and Paragraph&nbsp;9 of the Settlement Agreement. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>17</FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="me2030_article_11_miscellaneous"> </A>
<A NAME="toc_me2030_1"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 11<BR>  MISCELLANEOUS    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.1&nbsp;</FONT><FONT
SIZE=2><I>Assignment.</I></FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;ROCHE
and its Affiliates may not assign or transfer any rights under this Agreement without the prior written consent of CHIRON, except to a ROCHE Affiliate, and
then only for so long as the assignee remains a ROCHE Affiliate, or as part of the sale or transfer of all or substantially all of ROCHE's and all of its Affiliates' assets and businesses to which
this Agreement relates. In the case of a permitted assignment or transfer, the performance of the assignee shall be guaranteed by ROCHE. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;CHIRON
and its Affiliates may not assign or transfer any rights under this Agreement without the prior written consent of ROCHE, except to a CHIRON Affiliate, and
then only for so long as the assignee remains a CHIRON Affiliate, or as part of the sale or transfer of all or substantially all of CHIRON's and all of its Affiliates' assets and businesses to which
this Agreement relates. In the case of a permitted assignment or transfer, the performance of the assignee shall be guaranteed by CHIRON. </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.2&nbsp;</FONT><FONT
SIZE=2><I>Force Majeure.</I></FONT><FONT SIZE=2> A party hereto shall not be liable for, nor shall this Agreement be terminable or cancelable by
reason of, any delay or default in any such party's performance hereunder, to the extent that such default or delay is caused by events beyond such party's reasonable control including, but not
limited to: acts of God; regulation, law or action of any government or agency thereof; war or insurrection; civil commotion; labor disturbances; epidemic; or failure of suppliers, public utilities or
common carriers. Each party shall give prompt notice to the other party of such cause, and shall take whatever reasonable steps are necessary to relieve the effect of such cause as rapidly as
possible. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.3&nbsp;</FONT><FONT
SIZE=2><I>Severability.</I></FONT><FONT SIZE=2> In the event that any one or more of the provisions of this Agreement should for any reason be held
by any court or authority having jurisdiction over this Agreement or over the parties hereto to be invalid, illegal or unenforceable, such provision or provisions shall be reformed to approximate as
nearly as possible the intent of the parties, in such jurisdiction; elsewhere, this Agreement shall not be affected. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.4&nbsp;</FONT><FONT
SIZE=2><I>Entire Agreement; Termination of Interim Agreement.</I></FONT><FONT SIZE=2> This Agreement together with the Exhibits, Attachments and
Schedules constitutes the entire agreement among the parties relating to the subject matter of this Agreement. Upon execution and delivery of this Agreement, the parties acknowledge and agree that the
Interim Agreement shall be terminated and of no further force or effect, except as to those provisions of the Interim Agreement that expressly survive any termination or expiration or as specifically
referenced in this Agreement. There are no other understandings, representations or warranties of any kind. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.5&nbsp;</FONT><FONT
SIZE=2><I>Amendment.</I></FONT><FONT SIZE=2> This Agreement shall not be altered, extended or modified except by written agreement of the parties. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.6&nbsp;</FONT><FONT
SIZE=2><I>Waiver.</I></FONT><FONT SIZE=2> Failure by a party hereunder to enforce any right under this Agreement shall not be construed as a waiver
of such right or any other rights under this Agreement; nor shall a waiver by a party hereunder in one or more instances be construed as constituting a continuing waiver or as a waiver in other
instances. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.7&nbsp;</FONT><FONT
SIZE=2><I>Costs.</I></FONT><FONT SIZE=2> Each of the parties hereto shall be responsible for its respective legal and other costs incurred in
relation to the preparation of this Agreement. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.8&nbsp;</FONT><FONT
SIZE=2><I>Counterparts.</I></FONT><FONT SIZE=2> This Agreement may be executed in two (2)&nbsp;or more counterparts, each of which shall be deemed
to be an original, but all of which, taken together, shall constitute one and the same instrument. Facsimile copies of signatures for a party shall be deemed to be originals for purposes of execution
of the Agreement. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>18</FONT></P>

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<P><FONT SIZE=2>
&nbsp;&nbsp;&nbsp;&nbsp;11.9&nbsp;</FONT><FONT SIZE=2><I>Notices.</I></FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Any
notice or other document to be given under this Agreement shall be in writing and shall be deemed to have been duly given if personally delivered or sent by
first class mail, or express or air mail or other postal service, or by certified mail, return receipt requested. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Any
notice required by this Agreement shall be forwarded to the respective addresses and marked for the attention of the persons set forth below unless such
addresses subsequently change by written notice to the other party: </FONT></P>
</UL>
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<TABLE WIDTH="78%" BORDER=0 CELLSPACING=0 CELLPADDING=0>
<TR VALIGN="TOP">
<TD WIDTH="12%"><FONT SIZE=2><B>ROCHE:</B></FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="86%"><FONT SIZE=2>F. Hoffmann-La Roche&nbsp;Ltd.<BR>
Grenzacherstrasse 124<BR>
Basel<BR>
Bale 4002<BR>
Switzerland<BR>
Attn: Head of Diagnostics Division</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="12%"><FONT SIZE=2><BR>
Copy to:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="86%"><FONT SIZE=2><BR>
General Counsel<BR>
Roche Molecular Systems,&nbsp;Inc.<BR>
1145 Atlantic Avenue<BR>
Alameda, CA 94501</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="12%"><BR><FONT SIZE=2><B>CHIRON:</B></FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="86%"><FONT SIZE=2><BR>
Chiron Corporation<BR>
4560 Horton Street<BR>
Emeryville, California 94608<BR>
Attn.: President, Blood Testing</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="12%"><FONT SIZE=2><BR>
Copy to:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="86%"><FONT SIZE=2><BR>
General Counsel<BR>
Chiron Corporation<BR>
4560 Horton Street<BR>
Emeryville, CA 94608</FONT></TD>
</TR>
</TABLE>
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<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Any
such notice or other document shall be deemed to have been effective when received by the addressee. To prove the giving of a notice or other document it shall
be sufficient to show that it was received. </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.10&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>Governing Law.</I></FONT><FONT SIZE=2> All matters affecting the interpretation, form, validity, performance and termination of this
Agreement shall be decided and interpreted under the laws of the State of New York, excluding any choice of law rules which may direct application of the laws of any other jurisdiction. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.11&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>Relationship of the Parties.</I></FONT><FONT SIZE=2> The relationship of the parties under this Agreement is that of independent
contractors. Nothing contained in this Agreement is intended or is to be construed so as to constitute the parties as partners, joint venturers or agents of the other. Neither party or its Affiliates
has any express or implied right or authority under this Agreement to assume or create any obligations or make any representations or warranties on behalf of or in the name of the other party or its
Affiliates. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.12&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>Headings.</I></FONT><FONT SIZE=2> The headings of the Articles and Sections in this Agreement have been inserted for convenience only and
do not constitute part of this Agreement. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;11.13&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>No Trademark Rights.</I></FONT><FONT SIZE=2> No right, express or implied, is granted by this Agreement to either party to use in any
manner the name, trade name or trademark of the other party in connection with the performance of this Agreement. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>19</FONT></P>

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<P><FONT SIZE=2>
&nbsp;&nbsp;&nbsp;&nbsp;11.14&nbsp;&nbsp;</FONT><FONT SIZE=2><I>No Implied Licenses.</I></FONT><FONT SIZE=2> No license, express or implied, is granted by this Agreement to either party, other than the
licenses or options granted under Sections 2.1, 2.3, 2.4 and 2.5. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="me2030_article_12_field_restrictions_and_other_covenants"> </A>
<A NAME="toc_me2030_2"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 12<BR>  FIELD RESTRICTIONS AND OTHER COVENANTS    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;12.1&nbsp;</FONT><FONT
SIZE=2><I>ROCHE Covenant Regarding </I></FONT><FONT SIZE=2><B><I>In Vitro</I></B></FONT><FONT SIZE=2><I> Diagnostics</I></FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;ROCHE
and its Affiliates shall not label or promote any CHIRON Licensed Product labeled or promoted for use in the Field in any respect for use in </FONT> <FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics; and ROCHE shall use commercially
reasonable efforts to prevent its Authorized Distributors from labeling or promoting any CHIRON
Licensed Products labeled or promoted for use in the Field in any respect for use in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics. Similarly, ROCHE and its Affiliates shall not
label or promote any Product licensed under the HIV Diagnostics Agreement and labeled or promoted for use in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics in any respect for use
in the Field; and ROCHE shall use commercially reasonable efforts to prevent its Authorized Distributors from labeling or promoting any Products licensed under the HIV Diagnostics Agreement and
labeled or promoted for use in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics in any respect for use in the Field. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Further,
ROCHE and its Affiliates and Authorized Distributors shall include on or with each CHIRON Licensed Product labeled or promoted for use in the Field a
statement to the effect that the CHIRON Licensed Product is not intended for use in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics, using language to be determined by ROCHE and
approved in advance in writing by CHIRON, which approval shall not be unreasonably withheld. The location of such notice shall be the product insert of such CHIRON Licensed Products or such other
reasonably prominent location to be determined by ROCHE. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;In
the event that ROCHE or CHIRON becomes aware of any material use in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics of CHIRON Licensed
Products labeled or promoted for use in the Field, such party will promptly notify the other in writing of the relevant facts and, if so requested by CHIRON, ROCHE will (i)&nbsp;meet
and confer with CHIRON in good faith to determine what steps either or both should take to abate such infringing use and (ii)&nbsp;notify in writing any of its customers that engages in such
infringing use that use of the relevant CHIRON Licensed Product in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics may infringe one or more of the CHIRON Licensed Patents.
Similarly, in the event that ROCHE or CHIRON becomes aware of any material use in the Field of Products licensed under the HIV Diagnostics Agreement and labeled or promoted for use in </FONT> <FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2>
Diagnostics, such party will promptly notify the other in writing of the relevant facts and, if so requested by CHIRON, ROCHE will
(i)&nbsp;meet and confer with CHIRON in good faith to determine what steps either or both should take to abate such infringing use and (ii)&nbsp;notify in writing any of its customers that engages
in such infringing use that use of the relevant Product in the Field may infringe one or more of the CHIRON Licensed Patents. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Enforcement
of the provisions set forth in this Section&nbsp;12.1 shall be suspended until [**]; provided however, that following such
period of suspension, subject to compliance with all applicable laws and regulations, ROCHE shall not offer for sale or sell to End Users other than Existing End Users for use in Blood Screening
Products configured for use primarily in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics, and provided further, that effective [**], ROCHE shall not offer
for sale or sell to any End User for use in Blood Screening Products configured for use primarily in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics. Nothing in this
Section&nbsp;12.1(d) shall prohibit ROCHE from offering for sale or selling to End Users Products configured for use primarily in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics
to satisfy the </FONT><FONT SIZE=2><I>bona fide</I></FONT><FONT SIZE=2> requirements of such End Users for use in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics and any Blood
Screening use by such End Users of any such Products configured for use primarily in </FONT><FONT SIZE=2><I>In Vitro</I></FONT><FONT SIZE=2> Diagnostics shall not be deemed a breach of this
Section&nbsp;12.1(d). </FONT></P>

</UL>
<P ALIGN="CENTER"><FONT SIZE=2>20</FONT></P>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;12.2&nbsp;</FONT><FONT
SIZE=2><I>Patent Marking.</I></FONT><FONT SIZE=2> ROCHE and its Affiliates shall include a patent notice on each CHIRON Licensed Product to identify
the CHIRON Licensed Patents which such CHIRON Licensed Product, but for the licenses granted herein, would infringe one or more Valid Claims (or for which royalties are being paid); provided, however,
identification of CHIRON Licensed Patents on a CHIRON Licensed Product shall in no way be deemed to be an admission by ROCHE or its Affiliates, or raise a presumption, that such CHIRON Licensed
Product is in fact covered by such CHIRON Licensed Patent. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="me2030_article_13_infringement_by_third_parties"> </A>
<A NAME="toc_me2030_3"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 13<BR>  INFRINGEMENT BY THIRD PARTIES    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;13.1&nbsp;</FONT><FONT
SIZE=2><I>Notice of Infringement.</I></FONT><FONT SIZE=2> Each party shall notify the other if it becomes aware of Infringing Third Party Sales.
CHIRON shall have the exclusive right to take action against any infringement of any of the CHIRON Licensed Patents, in its sole discretion, subject to this Article&nbsp;13. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;13.2&nbsp;</FONT><FONT
SIZE=2><I>Infringement Litigation.</I></FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;In
the event that "substantial" Infringing Third Party Sales are occurring in a country in which ROCHE or its Affiliates or an Authorized Distributor is selling a
CHIRON Licensed Product (in each such country, the "Impacted Product"), and ROCHE has notified CHIRON pursuant to Section&nbsp;13.1 of the existence of such infringement in
[**] (an "Infringement Notice"), then the provisions of this Section&nbsp;13.2 shall apply. For purposes of this Section&nbsp;13.2, "Major Country" shall mean
[**]. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;For
purposes of this Section&nbsp;13.2, an Infringing Third Party Sale shall be considered substantial in a country if the infringing third party achieves market
share, in the case of Blood Screening of at [**], and in the case of Plasma Fractionation of at [**] of the Aggregated Products in such country
[**]. For purposes of this Section&nbsp;13.2, "Aggregated Products" means the number of Units of CHIRON Licensed Products of the applicable Field Category plus the number of
Competitive Products sold (or used, in the case of Plasma Fractionation) in a country, and "Competitive Products" means the number of Units of Products which are sold (or used, in the case of Plasma
Fractionation) of the applicable Field Category and which compete with a CHIRON Licensed Product sold or used by ROCHE or its Affiliates in a country. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;If
the Infringement Notice identifies an Impacted Product in a Major Country and CHIRON fails to institute legal action in a Major Country or other country
acceptable to ROCHE [**] following receipt by CHIRON of the Infringement Notice and infringement is not otherwise abated, then ROCHE shall be relieved of the obligation to pay
the portion of Earned Royalties set forth in Section&nbsp;13.2(d) with respect to the Impacted Product until such time as CHIRON institutes such legal action as described in this
Section&nbsp;13.2(c); provided, however, that CHIRON need not initiate or continue any such legal action, if, after reasonably diligent effort (including reasonably diligent effort by ROCHE if
requested by CHIRON), CHIRON is unable to acquire admissible evidence sufficient to establish a prima facia case of infringement under the law of the applicable country; and provided further, that
CHIRON shall not be obligated to institute or maintain more than one such action [**] of this Agreement nor more than three such actions at any time with regard to Impacted
Products in Plasma Fractionation. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;If
CHIRON has not instituted such legal action at the end of such [**], to the extent required under Section&nbsp;13.2(c), and such
infringement is not otherwise abated, the Earned Royalty with respect to an Impacted Product in Blood Screening shall be reduced by [**] from the amount otherwise payable under
Paragraph&nbsp;1 of Exhibit&nbsp;A (excluding the effect of any reduction in Earned Royalty Amounts triggered by operation of Paragraph&nbsp;2 of Exhibit&nbsp;A) and with respect to an
Impacted Product in Plasma Fractionation shall be reduced by [**]. If, at the end of [**] thereafter, CHIRON has not instituted such legal action, to
the extent so required, and </FONT></P>

</UL>
<P ALIGN="CENTER"><FONT SIZE=2>21</FONT></P>

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<UL>

<P><FONT SIZE=2>
infringement is not otherwise abated, Earned Royalties on such Impacted Product shall be reduced by an [**] of the original Earned Royalties, such that if legal action required
under Section&nbsp;13.2(c) has not commenced and the infringement is not otherwise abated by, in the case of an Impacted Product in
Blood Screening the end of the [**] following receipt by CHIRON of the Infringement Notice and in the case of an Impacted Product in Plasma Fractionation the end of the
[**] following receipt by CHIRON of the Infringement Notice, [**] shall be payable hereunder with respect to the Impacted Product. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;The
obligations to pay Earned Royalties shall be reinstated on a prospective basis at such time as ROCHE receives written notice of the institution of legal action
in accordance with Section&nbsp;13.2(c) or the infringement is otherwise abated, all subject to Section&nbsp;13.2(f). </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;&nbsp;If
legal action required under Section&nbsp;13.2(c) has not been instituted and the infringement is not otherwise abated in the case of an Impacted Product in
Blood Screening for more than [**] following receipt by CHIRON of the Infringement Notice and in the case of an Impacted Product in Plasma Fractionation for more than
[**] following receipt by CHIRON of the Infringement Notice, and if, as a result of the infringement, sales of the Impacted Product [**] by ROCHE, its
Affiliates or an Authorized Distributor have declined by [**] or more during the preceding [**], then upon reinstatement of Earned Royalties pursuant to
Section&nbsp;13.2(e), the parties shall meet and confer regarding possible adjustments to the Earned Royalties for the Impacted Product in view of such degradation of the market. The parties will
discuss possible rate reductions, as well as a plan for reinstating the original economic expectations of the parties. It is expected that any agreement for reduction of Earned Royalties will be
phased out over time, so as to return to the Earned Royalties set forth in Exhibit&nbsp;A. If the parties fail to reach agreement on any such adjustment, the matter shall be submitted for resolution
by ADR, except that in the event of ADR, each party shall submit to the neutral a proposal with respect to adjustments pursuant to this Section&nbsp;13.2(f). The neutral shall be empowered to choose
one proposal or the other, but shall not be empowered to order any such adjustment other than as proposed by one of the parties. </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;13.3&nbsp;</FONT><FONT
SIZE=2><I>Cooperation.</I></FONT><FONT SIZE=2> ROCHE and its Affiliates shall cooperate with CHIRON in connection with any legal action referred to
in this Article&nbsp;13. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="me2030_article_14_european_community_provisions"> </A>
<A NAME="toc_me2030_4"> </A>
<BR></FONT><FONT SIZE=2><B>ARTICLE 14<BR>  EUROPEAN COMMUNITY PROVISIONS    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;14.1&nbsp;</FONT><FONT
SIZE=2><I>Termination in European Community.</I></FONT><FONT SIZE=2> Notwithstanding the provisions of Article&nbsp;7, this Agreement, with respect
to the European Community, shall terminate in each member country seventeen (17)&nbsp;years from the Effective Date or on the expiration of the last to expire of the patents within the CHIRON
Licensed Patents in such member country based upon a patent existing or a patent application pending as of the Effective Date, whichever is later; provided, however, that prior to the termination of
this Agreement in the first member country in which it would otherwise terminate pursuant to the foregoing, ROCHE may, in its discretion, elect by written notice to CHIRON to extend this Agreement as
to all such member countries for an additional term which shall expire on a country-by-country basis on the expiration date of the last to expire patent within the CHIRON
Licensed Patents existing in such member country as of the date of such extension. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;14.2&nbsp;</FONT><FONT
SIZE=2><I>Competition Notification.</I></FONT><FONT SIZE=2> If either party (the "Notifying Party") elects to file&nbsp;a notification with respect
to this Agreement (a "Notification") with the Competition Directorate of Commission of European Community (the "Commission") in accordance with regulations established by the Commission, the Notifying
Party shall provide a non-confidential version of the final draft to the other party for comment at least thirty (30)&nbsp;days before making the filing and shall consider in good faith
the modification thereto, if any, that the other party may propose. The other party shall execute all documents reasonably required by the Notifying Party and shall otherwise reasonably cooperate in </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>22</FONT></P>

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<A NAME="page_me2030_1_23"> </A>

<P><FONT SIZE=2>
connection with the Notification. The Notifying Party shall bear all costs incurred by it relating to the Notification. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;14.3&nbsp;</FONT><FONT
SIZE=2><I>Reformation.</I></FONT><FONT SIZE=2> If, at any time during the Term, either party receives a request or other communication from the
Commission with respect to the Notification (a "Request"), such party shall promptly inform the other of the nature of the Request. In the event that the Commission indicates in a Statement of
Objection(s) that this Agreement will violate the provisions of Article&nbsp;81 or 82 of the Treaty of Rome, then the parties shall amend this Agreement by making those minimal modifications
necessary to satisfy the concerns of the Commission as set forth in the Statement of Objection(s). Notwithstanding the foregoing, the parties agree that ROCHE shall retain substantially the same
license rights at substantially the same royalties as specified under this Agreement. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;IN
WITNESS WHEREOF this Agreement has been executed by duly authorized officers of CHIRON and ROCHE as of the Effective Date. </FONT></P>

<!-- User-specified TAGGED TABLE -->
<TABLE WIDTH="100%" BORDER=0 CELLSPACING=0 CELLPADDING=0>
<TR VALIGN="TOP">
<TD COLSPAN=3><FONT SIZE=2><B>CHIRON CORPORATION</B></FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
By:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>SE&Aacute;N P. LANCE</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Se&aacute;n P. Lance</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
Title:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2><BR>
Chairman and Chief Executive Officer</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2>Date:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2>May&nbsp;22, 2001</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD COLSPAN=3><BR><FONT SIZE=2><B>F. HOFFMANN-LA ROCHE&nbsp;LTD</B></FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
By:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>HEINO VON PRONDYZNSKI</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Heino von Prondyznski</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
Title:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2><BR>
Head of Roche Diagnostics</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
Date:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2><BR>
21/05/01</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
By:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><BR><HR NOSHADE></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
Title:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
Date:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="34%"><HR NOSHADE></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD COLSPAN=3><BR><FONT SIZE=2><B>ROCHE MOLECULAR SYSTEMS,&nbsp;INC.</B></FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
By:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>HEINER DREISMANN</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Heiner Dreismann</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
Title:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2><BR>
President, RMS</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="6%"><FONT SIZE=2><BR>
Date:</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="34%"><FONT SIZE=2><BR>
05/09/01</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="55%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
</TABLE>
<!-- end of user-specified TAGGED TABLE -->

<P ALIGN="CENTER"><FONT SIZE=2>23</FONT></P>

<HR NOSHADE>
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<!-- TOC_END -->
<P ALIGN="RIGHT"><FONT SIZE=2><B>REDACTED  </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mf2030_exhibit_a_compensation_to_chiron_corporation"> </A>
<A NAME="toc_mf2030_1"> </A>
<BR></FONT><FONT SIZE=2><B>Exhibit&nbsp;A<BR>  <BR>    Compensation to Chiron Corporation    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;1.&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>Earned Royalty.</I></FONT><FONT SIZE=2> Subject to the adjustments referenced in this Exhibit&nbsp;A, royalties paid to CHIRON under this
Agreement in any Calendar Quarter (the "Earned Royalty") shall be calculated as follows: </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
Earned Royalty for each Calendar Quarter shall be the [**]: </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mf2030_earned_royalty_amounts"> </A>
<A NAME="toc_mf2030_2"> </A>
<BR></FONT><FONT SIZE=2><B>Earned Royalty Amounts    <BR>  </B></FONT></P>

<!-- User-specified TAGGED TABLE -->
<TABLE WIDTH="77%" BORDER=0 CELLSPACING=0 CELLPADDING=0>
<TR VALIGN="BOTTOM">
<TH WIDTH="60%" ALIGN="LEFT"><FONT SIZE=1><B>Field Category:<BR> </B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="8%" ALIGN="CENTER"><FONT SIZE=1><B>Region&nbsp;I</B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="7%" ALIGN="CENTER"><FONT SIZE=1><B>Region&nbsp;II</B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="8%" ALIGN="CENTER"><FONT SIZE=1><B>Region&nbsp;III</B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="7%" ALIGN="CENTER"><FONT SIZE=1><B>Region&nbsp;IV</B></FONT><HR NOSHADE></TH>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="60%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="8%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="7%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="8%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="7%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="60%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="8%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="7%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="8%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="7%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
</TR>
</TABLE>
<!-- end of user-specified TAGGED TABLE -->

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Notwithstanding
the above: </FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;For
Blood Screening: </FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;In
Region I, for Existing End Users only, the Earned Royalty Amount shall be [**] used by such Existing End Users in Region I
[**], and as to Units used by End Users other than Existing End Users, the Earned Royalty Amount shall be as set forth above; </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;In
Region II, </FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(A)&nbsp;As
to the [**], the Earned Royalty Amount shall be [**]; provided, however, that [**]; and </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(B)&nbsp;As
to [**], the Earned Royalty Amount shall be [**]; provided, however, that [**]; and </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;In
Region III, the Earned Royalty Amount shall be [**]; and </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;[**],
as such terms are defined in the Interim Agreement, referenced in that certain letter agreement dated October&nbsp;10, 2000 by and
between CHIRON and F. Hoffmann-La Roche&nbsp;Ltd. (the "Plasma Letter") [**]. </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Notwithstanding
the above, [**]. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;[**],
the parties shall meet and reasonably consider adjustment to the Earned Royalty Amount with respect to each CHIRON Licensed Product
[**]. Any such adjustment should reflect both [**]. Accordingly, an increase in Earned Royalty Amounts may be justified by an increase
[**]. Generally, the parties intend that Earned Royalty Amounts should be not less than [**]. No adjustment shall be made to any Earned Royalty Amount
unless mutually agreed; [**]. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Earned
Royalties shall be payable quarterly, commencing with the Calendar Quarter ending [**], within seventy-five
(75)&nbsp;days following the end of each Calendar Quarter. Such payment shall be made in accordance with the payment and reporting obligations set forth in Article&nbsp;4 and is fully earned when
paid and is non-refundable. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;[**],
the parties shall meet and reasonably consider adjustment to the allocation of jurisdictions among the Regions set forth on
Exhibit&nbsp;G. Generally, the parties intend that a [**]. No adjustment shall be made to the allocation of jurisdictions among the Regions unless mutually agreed. </FONT></P>

</UL>
<HR NOSHADE>
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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>Home Brew Adjustment.</I></FONT><FONT SIZE=2> With respect to sales of CHIRON Licensed Products in [**] for use in
Blood Screening, [**] as set forth in this Paragraph&nbsp;2, [**], if in the[**]: </FONT></P>

<!-- User-specified TAGGED TABLE -->
<DIV ALIGN="CENTER"><TABLE WIDTH="47%" BORDER=0 CELLSPACING=0 CELLPADDING=0>
<TR VALIGN="BOTTOM">
<TH WIDTH="34%" ALIGN="CENTER"><FONT SIZE=1><B>[**]<BR>
[**]</B></FONT><BR></TH>
<TH WIDTH="4%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="62%" ALIGN="CENTER"><FONT SIZE=1><B>Reduced<BR>
Earned Royalty Amount</B></FONT><HR NOSHADE></TH>
</TR>
<TR VALIGN="BOTTOM">
<TH WIDTH="34%" ALIGN="CENTER"><FONT SIZE=1><B>(in units)<BR> </B></FONT><BR></TH>
<TH WIDTH="4%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="62%" ALIGN="LEFT"><FONT SIZE=1>&nbsp;</FONT><BR></TH>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="34%"><FONT SIZE=2>greater than [**]</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="62%"><FONT SIZE=2>[**] of existing Earned Royalty Amount</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="34%"><FONT SIZE=2>greater than [**]</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="62%"><FONT SIZE=2>[**] of existing Earned Royalty Amount</FONT></TD>
</TR>
</TABLE></DIV>
<!-- end of user-specified TAGGED TABLE -->


<P><FONT SIZE=2>If
the parties are unable otherwise to agree within thirty (30)&nbsp;days of a request by either party, [**]. In the event that Home Brew Screening achieve a market share in
[**] Blood Screening in [**], the parties shall meet and confer, at ROCHE's request, to consider reasonably and in good faith the actions that CHIRON
might take to abate such Home Brew Screening. [**]. As used herein, "Home Brew Screening" shall mean the use in Blood Screening of probe screening methods Directed to HIV not
licensed by CHIRON and not utilizing any assay, kit, reagent or other component Directed to HIV made by or for ROCHE. ROCHE may have the benefit of the adjustment to Earned Royalty Amounts provided by
this Paragraph&nbsp;2 or the adjustment to Earned Royalty Amounts provided under Section&nbsp;13.2, at its election, but not both. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;3.&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>Pre-Licensing Royalties.</I></FONT><FONT SIZE=2> Notwithstanding anything to the contrary in the Agreement or this
Exhibit&nbsp;A, Earned Royalties shall be paid on Units in the United States under investigational new drug (IND) status and, similarly, on Units in any other jurisdiction for investigational or
other pre-licensure use. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;4.&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>Most Favored Licensee.</I></FONT><FONT SIZE=2> CHIRON shall promptly notify ROCHE if it grants to a third party a license under CHIRON
Licensed Patents to practice in Blood Screening or Plasma Fractionation under terms that impose [**] of the applicable Earned Royalty Amounts. With such notification, CHIRON
shall provide ROCHE with a summary of [**]. At ROCHE's election, to be made in writing [**] hereunder
shall be adjusted [**]. Any such adjustment will be subject to the same terms as are applicable to such minimum amounts payable by such third party, including, without
limitation, [**]. This Paragraph&nbsp;4 only applies to licenses that enable a third party to sell or use Products Directed to HIV for Blood Screening; provided, however, it
does not apply to licenses of Products Directed to HIV for Blood Screening that do not compete with Products then being sold by ROCHE. It also does not apply to a license that amends, replaces or
supplements CHIRON's arrangement [**]. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;5.&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>Single Royalty Per CHIRON Licensed Product.</I></FONT><FONT SIZE=2> Only one payment of Earned Royalty shall be due with respect to any Net
Sales or only one payment of Earned Royalty Amount shall be due with respect to any Unit of CHIRON Licensed Product Shipped, irrespective of the number of patents or Valid Claims in the CHIRON
Licensed Patents covering such CHIRON Licensed Product. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;6.&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>Dispute Resolution.</I></FONT><FONT SIZE=2> Except as set forth in Paragraph&nbsp;2 of this Exhibit&nbsp;A, any dispute between CHIRON
and ROCHE regarding whether any adjustment to or credits against Earned Royalties under this Exhibit&nbsp;A is appropriate, and which the parties fail to resolve themselves may only be resolved by
resort to the ADR provisions of Article&nbsp;10. Until such dispute is resolved, ROCHE shall pay CHIRON the Earned Royalty provided for herein without benefit of the applicable disputed adjustment
on the condition that CHIRON shall repay ROCHE the amounts of such disputed payments if ROCHE prevails in the ADR, plus interest at the rate described in Section&nbsp;4.9. </FONT></P>

<HR NOSHADE>
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<!-- TOC_END -->
<P ALIGN="RIGHT"><FONT SIZE=2><B>REDACTED  </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mg2030_exhibit_b__#151;_blood_screeni__exh02084"> </A>
<A NAME="toc_mg2030_1"> </A>
<BR></FONT><FONT SIZE=2><B>Exhibit B &#151; Blood Screening<BR>  Page 1 of 1<BR>  <BR>    Chiron HIV Patents    <BR>  </B></FONT></P>

<P><FONT SIZE=2>[**]<BR>
[**] </FONT></P>

<P><FONT SIZE=2>[**]<BR>
[**] </FONT></P>

<P><FONT SIZE=2>[**]<BR>
[**]<BR>
[**] </FONT></P>

<P><FONT SIZE=2>[**]<BR>
[**] </FONT></P>

<HR NOSHADE>
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<!-- Generated by Merrill Corporation (www.merrillcorp.com) -->
<!-- TOC_END -->
<P ALIGN="RIGHT"><FONT SIZE=2><B>REDACTED  </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mh2030_exhibit_c__#151;_hiv_page_1_of_1_roche_hiv_patents"> </A>
<A NAME="toc_mh2030_1"> </A>
<BR></FONT><FONT SIZE=2><B>Exhibit C &#151; HIV<BR>  Page 1 of 1    <BR>    <BR>    Roche HIV Patents    <BR>  </B></FONT></P>

<P><FONT SIZE=2>[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**] </FONT></P>

<P><FONT SIZE=2>[**]<BR>
[**]<BR>
[**] </FONT></P>

<P><FONT SIZE=2>[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**]<BR>
[**] </FONT></P>

<HR NOSHADE>
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<!-- Generated by Merrill Corporation (www.merrillcorp.com) -->
<!-- TOC_END -->
<P ALIGN="RIGHT"><FONT SIZE=2><B>REDACTED  </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mi2030_exhibit_d"> </A>
<A NAME="toc_mi2030_1"> </A>
<BR></FONT><FONT SIZE=2><B>EXHIBIT D    <BR>  </B></FONT></P>

<P><FONT SIZE=2><B>Product Codes, BS kits:  </B></FONT></P>

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<DIV ALIGN="CENTER"><TABLE WIDTH="63%" BORDER=0 CELLSPACING=0 CELLPADDING=0>
<TR VALIGN="BOTTOM">
<TH WIDTH="84%" ALIGN="LEFT"><FONT SIZE=1><B>Description<BR> </B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="13%" ALIGN="CENTER"><FONT SIZE=1><B>SAP/Part No.</B></FONT><HR NOSHADE></TH>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="84%"><FONT SIZE=2><B>[**]</B></FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="13%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="84%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="13%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="84%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="13%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="84%"><FONT SIZE=2><BR>
[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="13%" ALIGN="RIGHT"><FONT SIZE=2><BR>
[**]</FONT></TD>
</TR>
</TABLE></DIV>
<!-- end of user-specified TAGGED TABLE -->

<HR NOSHADE>
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<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mj2030_exhibit_e_form_of_repor__mj202293"> </A>
<A NAME="toc_mj2030_1"> </A>
<BR></FONT><FONT SIZE=2><B>Exhibit&nbsp;E    <BR>    <BR>    Form of Report<BR>  <BR>    </B></FONT><FONT SIZE=2>[To Be Agreed To By The Parties.]    <BR></FONT></P>

<HR NOSHADE>
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<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="mk2030_exhibit_f_existing_licenses_or__exh04389"> </A>
<A NAME="toc_mk2030_1"> </A>
<BR></FONT><FONT SIZE=2><B>Exhibit&nbsp;F<BR>  <BR>    Existing Licenses or Rights granted in the Field under the Licensed Patents<BR>  as of the Effective Date    <BR>  </B></FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;2.&nbsp;&nbsp;Agreement
between Gen-Probe Incorporated and Chiron Corporation dated as of June&nbsp;11, 1998 (the "Gen-Probe Agreement"). </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;[**]
</FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;[**]
</FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;[**]
</FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;[**]
</FONT></P>

<HR NOSHADE>
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<!-- TOC_END -->
<P ALIGN="RIGHT"><FONT SIZE=2><B>REDACTED  </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="ml2030_exhibit_g_regions"> </A>
<A NAME="toc_ml2030_1"> </A>
<BR></FONT><FONT SIZE=2><B>Exhibit&nbsp;G<BR>  <BR>    Regions    <BR>  </B></FONT></P>

<P><FONT SIZE=2><B>Region I  </B></FONT></P>

<!-- User-specified TAGGED TABLE -->
<DIV ALIGN="CENTER"><TABLE WIDTH="73%" BORDER=0 CELLSPACING=0 CELLPADDING=0>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2><SUP>1</SUP></FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%" ALIGN="RIGHT"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="80%"><FONT SIZE=2>[**]</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%"><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
</TABLE></DIV>
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<P><FONT SIZE=2><B>Region II  </B></FONT></P>

<P><FONT SIZE=2>[**]<BR>
[**] </FONT></P>

<P><FONT SIZE=2><B>Region III  </B></FONT></P>

<P><FONT SIZE=2>[**]
</FONT></P>

<P><FONT SIZE=2><B>Region IV  </B></FONT></P>

<P><FONT SIZE=2>[**]
</FONT></P>

<HR NOSHADE ALIGN="LEFT" WIDTH="120">


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;<SUP>1</SUP>&nbsp;&nbsp;If
[**], as the case may be, fails to implement a program for use of Products Directed to HCV for Blood
Screening prior to [**], the parties shall meet and confer to determine whether [**] shall be deemed to be within Region&nbsp;IV, subject to
Paragraph&nbsp;5 of Exhibit&nbsp;A. If such failure continues beyond [**], then [**], as the case may be, shall thereafter be deemed to be within
Region IV, subject to Paragraph&nbsp;5 of Exhibit&nbsp;A </FONT></P>

<P><FONT SIZE=2><B>[**] CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED
PORTIONS.</B></FONT></P>

<HR NOSHADE>
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<P><br><A NAME="01SFO2029_6">QuickLinks</A><br></P><!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_ma2030_1">BLOOD SCREENING HIV PROBE LICENSE AGREEMENT between CHIRON CORPORATION F. HOFFMANN-LA ROCHE LTD. and ROCHE MOLECULAR SYSTEMS, INC.</A></FONT><BR>

<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_mb2030_1">BLOOD SCREENING HIV PROBE LICENSE AGREEMENT TABLE OF CONTENTS</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_mc2030_1">BLOOD SCREENING HIV PROBE LICENSE AGREEMENT</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_mc2030_2">BACKGROUND</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_mc2030_3">ARTICLE 1 DEFINITIONS</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_mc2030_4">ARTICLE 2 LICENSE AND OPTION GRANTS</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_mc2030_5">ARTICLE 3 PAYMENTS, ROYALTIES</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_mc2030_6">ARTICLE 4 RECORDS AND REPORTS</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_md2030_1">ARTICLE 5 OTHER ACTIONS</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_md2030_2">ARTICLE 6 REPRESENTATIONS AND WARRANTIES</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_md2030_3">ARTICLE 7 TERM AND TERMINATION</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_md2030_4">ARTICLE 8 CONFIDENTIALITY</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_md2030_5">ARTICLE 9 INDEMNITY</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_md2030_6">ARTICLE 10 ALTERNATIVE DISPUTE RESOLUTION</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_me2030_1">ARTICLE 11 MISCELLANEOUS</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_me2030_2">ARTICLE 12 FIELD RESTRICTIONS AND OTHER COVENANTS</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_me2030_3">ARTICLE 13 INFRINGEMENT BY THIRD PARTIES</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_me2030_4">ARTICLE 14 EUROPEAN COMMUNITY PROVISIONS</A></FONT><BR>

<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_mf2030_1">Exhibit A Compensation to Chiron Corporation</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_mf2030_2">Earned Royalty Amounts</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_mg2030_1">Exhibit B &#151; Blood Screening Page 1 of 1 Chiron HIV Patents</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_mh2030_1">Exhibit C &#151; HIV Page 1 of 1 Roche HIV Patents</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_mi2030_1">EXHIBIT D</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_mj2030_1">Exhibit E Form of Report [To Be Agreed To By The Parties.]</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_mk2030_1">Exhibit F Existing Licenses or Rights granted in the Field under the Licensed Patents as of the Effective Date</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_ml2030_1">Exhibit G Regions</A></FONT><BR>
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