IMMUNE RESPONSE CORP
EXHIBIT 10.95
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<BR></FONT><FONT SIZE=2><B>Exhibit&nbsp;10.95    <BR>  </B></FONT></P>

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<BR></FONT><FONT SIZE=2><B>AMENDMENT NO. 3 TO NOTE PURCHASE AGREEMENT    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This AMENDMENT NO. 3 is made as of the 11th day of July, 2002 (the "Amendment") by and between Kevin Kimberlin Partners, L.P., a Delaware limited partnership
("KKP"), The Immune Response Corporation, a Delaware corporation ("Seller"), Oshkim Limited Partnership ("Oshkim") and The Kimberlin Family 1998 Irrevocable Trust (the "Trust"); </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;WHEREAS,
Seller, KKP and Oshkim entered into that certain Note Purchase Agreement dated as of November&nbsp;9, 2001, as amended by Amendment No.&nbsp;1 to Note Purchase Agreement
dated as of February&nbsp;14, 2002 and as further amended by Amendment No.&nbsp;2 to Note Purchase Agreement dated as of May&nbsp;3, 2002 (the "Agreement"); </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;WHEREAS,
the Seller proposes to issue and sell Additional Securities to the Trust and the Trust wishes to purchase Additional Securities from Seller. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;WHEREAS,
the parties desire to amend the Agreement to add the Trust and any affiliates of KKP, Oshkim and/or the Trust as parties and in certain other respects as set forth below. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NOW,
THEREFORE, in consideration of the foregoing premises and the mutual covenants set forth below, the parties hereby amend the Agreement and agree as follows: </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.&nbsp;&nbsp;&nbsp;&nbsp;Effective
as of the date of this Amendment, the Agreement is hereby amended as follows: </FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a.&nbsp;&nbsp;&nbsp;&nbsp;The
Trust and any affiliates of KKP, Oshkim and/or the Trust shall be parties to the Agreement. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b.&nbsp;&nbsp;&nbsp;&nbsp;All
references in the Agreement to "Buyer" for all purposes related to Additional Securities shall be deemed to refer to the Trust and any affiliates of KKP, Oshkim
and/or the Trust. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c.&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;9
is hereby amended to add subsections (v)&nbsp;and (vi)&nbsp;which shall read in their entirety as follows: </FONT></P>

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<P><FONT SIZE=2>"(v)&nbsp;if
Seller shall default in the payment of principal on any indebtedness (to any party other than Buyer) in excess of $200,000 beyond the period of grace, if any, provided in the instrument
or agreement under which such indebtedness was created," </FONT></P>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.&nbsp;&nbsp;&nbsp;&nbsp;Except
as specifically provided herein, the Agreement, as originally executed by the parties thereto and as amended hereby, shall remain in full force and effect. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.&nbsp;&nbsp;&nbsp;&nbsp;Any
defined terms not defined herein shall have the respective meanings set forth in the Agreement. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.&nbsp;&nbsp;&nbsp;&nbsp;This
Amendment may be executed in counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.&nbsp;&nbsp;&nbsp;&nbsp;This
Amendment shall be governed by and construed in accordance with the internal laws of the State of New York applicable to agreements made and to be performed entirely
within such jurisdiction. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>1</FONT></P>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IN
WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written. </FONT></P>

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KEVIN KIMBERLIN PARTNERS, L.P.</FONT></TD>
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OSHKIM LIMITED PARTNERSHIP</FONT></TD>
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THE KIMBERLIN FAMILY 1998 IRREVOCABLE TRUST</FONT></TD>
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THE IMMUNE RESPONSE CORPORATION</FONT></TD>
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<P><br><A NAME="02SAN1698_4">QuickLinks</A><br></P><!-- TOC_BEGIN -->
<UL>
<FONT SIZE=2><A HREF="#toc_kk1698_1">Exhibit 10.95</A></FONT><BR>
</UL>
<FONT SIZE=2><A HREF="#toc_kk1698_2">AMENDMENT NO. 3 TO NOTE PURCHASE AGREEMENT</A></FONT><BR>

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