KOS PHARMACEUTICALS INC
EMPLOYMENT LETTER
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<DIV align="right" style="font-size: 10pt; margin-top: 12pt"><B>Exhibit&nbsp;10.22</B>
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<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><IMG src="g00234g0023401.gif" alt="(KOS Logo)">
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<DIV align="left" style="font-size: 10pt; margin-top: 12pt">October&nbsp;14, 2005
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<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>- Revised -</B>
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<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CONFIDENTIAL</B>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Mr.&nbsp;Kevin Clarke<BR>
130 Fairway Avenue<BR>
Verona, NJ 07044

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<DIV align="left" style="font-size: 10pt; margin-top: 12pt">Dear Kevin:
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;I am delighted to confirm to you this offer of employment, which you have accepted, as Executive
Vice President and Chief Financial Officer at Kos Pharmaceuticals. In this capacity you will report to me.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Your date of hire will be November&nbsp;1, 2005 and your salary, which will be paid bi-weekly,
will be at an annual rate of $370,000. On January&nbsp;1, 2006 your salary will be increased
to an annual rate of $400,000 and your next salary review will be in March&nbsp;2007, consistent with
Kos&#146; Performance Management Program. You will also be paid a signing bonus of $300,000-
$100,000 will be paid upon your start date (payment will occur on the first pay-period after your
start date) and $200,000 will be paid on March&nbsp;1, 2006, provided you are still employed with the
Company on that date. Your target performance bonus will be around 50% of your current base
compensation but not less than $250,000 for the calendar year 2006, and not less than $300,000
for the calendar year 2007, based on your continued employment and satisfactory performance.
After 2007, you will, of course, continue to be eligible for annual performance bonuses based on
your contributions and the results of the Company. Although it is impossible to commit to what
these bonus amounts might be, I would expect them to be at least in line with the bonus awards
paid to other executives at a similar level and with comparable performance, generally around
50% of base compensation. These bonus payments are usually made in the first quarter of the
following calendar year after review by the Compensation Committee of the Board of Directors.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Subject
to the approval of the Board of Directors, you will be granted an option to
purchase 100,000 shares of Kos common stock, consistent with the Company&#146;s 1996 Stock
Option Plan (the &#147;Stock Option Plan&#146;&#146;) that provides for vesting of 25% of the option shares on
each anniversary of your employment. The exercise price of these options shall be the price of
the stock on the day the Board approves the award. You will receive detailed information about
the Stock Option Plan and specific exercise price under separate cover. Additionally, subject to
Board approval, you will receive 8,000 shares of fully paid and non-assessable common stock of
the Company, (the &#147;Restricted Stock Shares&#148;), that will vest over a three-year period. In addition,
consistent with Kos Pharmaceuticals&#146; normal and customary incentive compensation awards, you
will be eligible for additional annual stock option grants and/or Restricted Stock Shares. Such
awards have traditionally been granted on an annual basis and it is anticipated will continue to be
an important element of our compensation plan. However, such awards are granted at the sole
discretion of the Compensation Committee of the Board of Directors and based on individual and
company performance.
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Kevin Clarke-Revised<BR>
Page 2 of 3

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;You will be eligible for all Company benefit plans, consistent with the enclosed information
regarding our benefits programs, plus an added health insurance benefit for Corporate officers
(which is not included in the accompanying information), subject to the terms of such plans.
Eligibility for medical insurance will begin on December&nbsp;1,
2005, and for the 401(k) plan, on March
1, 2006. You will be eligible for four weeks of paid vacation in addition to the Kos standard
fifteen paid holidays and an automobile allowance or a leased car with a retail value of up to
$70,000. You have the option of either leasing the chosen car through the Company&#146;s fleet vendor,
or receiving the equivalent cash value of the lease option as a cash payment paid each pay period.
Both of these options include allowances for insurance and maintenance.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In the event of a &#147;Change in Control&#146;&#146;, you may elect, at any time during the 90-day period
immediately following such change in control, to deliver written
notice to the Company of your
termination of employment. For purposes of this agreement, a Change on Control shall be deemed to
have occurred when:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;any person, including a &#147;group&#146;&#146; as defined in Section&nbsp;13(d)(3) of the
Securities Exchange Act of 1934, as amended, other than Michael Jabaris or any of his
family members or affiliates, becomes the beneficial owner of fifty percent or more of
the capital stock of the Company;
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;the Company is merged with or into any other company where members of the
Board of Directors of the Company immediately prior to such transaction do not
constitute a majority of the Board of Directors of the Company or the surviving entity
immediately following such transaction; or
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;substantially all of the Company&#146;s assets are acquired by any third party
not an affiliate of the Company or of Michael Jaharis, or any of his
family members or
affiliates.
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In the event of the termination of your employment with the Company, for any reason other
than death or disability, the Company shall provide the payments and benefits to you as
listed below:
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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(a)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Following a Change in Control: All unvested stock options and Restricted
Stock Shares previously awarded shall be 100% vested effective as of the date of such
Change in Control or upon termination following such Change in Control plus one years&#146;
compensation to include both your current base compensation and either (a)&nbsp;the agreed
guaranteed bonus (if such termination occurs in the calendar years 2006 or 2007) or
(b)&nbsp;a target bonus of no less than 50% of the current base compensation.</TD>
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<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(b)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Termination for cause as defined in section 6(f)(3) of the Stock Option Plan,
any unvested part of the options shall lapse immediately upon the earlier of the
occurrence of such event or the last day that you are employed by or affiliated with
the Company.</TD>
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<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(c)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Termination voluntarily without cause: In the event your employment or
affiliation with the Company ceases for any reason other than (a) (b)&nbsp;or (d)&nbsp;or death
or retirement, all unvested stock options shall expire thirty days following the last
day of employment. However, should you be terminated prior to the first anniversary of
your initial employment date, you will immediately vest in 25% of you initial stock
option grant (25,000 stock options shares) and these shares will be exercisable
consistent with the terms provided in the Company&#146;s 1996 Stock Option Plan. all
Restricted Stock Shares previously awarded shall be 100% vested immediately upon
termination.</TD>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Kevin Clarke-Revised<BR>
Page 3 of 3

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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(d)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>In the event that you are terminated involuntarily without cause: Stock
options previously awarded to you shall continue to vest for two years from the date
of termination (as though you were still employed by the Company) consistent with the
Company&#146;s 1996 Stock Option Plan. All Restricted Stock Shares previously awarded shall
be 100% vested immediately upon termination. In addition, you will receive one years&#146;
compensation to include both your current base compensation and either (a)&nbsp;the agreed
guaranteed bonus (if such termination occurs in the calendar years 2006 or 2007) or
(b)&nbsp;a target bonus of no less than 50% of the current base compensation.</TD>
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<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(e)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>In either the event of a Change in Control or termination for
cause,
voluntarily or involuntarily, you will also be paid any unused vacation entitlement.</TD>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As a condition of your employment, you will be required to sign (i)&nbsp;the Procedures and
Guidelines Governing Insider Trading and Disclosure, (ii)&nbsp;a Confidentiality and Intellectual
Property Agreement, and (iii)&nbsp;an Electronic and Telephonic Communications Policy. Two copies of
each document are enclosed; please sign one copy and return it in the enclosed envelope (the other
copy is for you to retain). This offer is also contingent upon successful completion of the Kos
background check and drug screen. Information regarding our drug screening process is enclosed in
your offer package. Please contact Jessica Zenkert in the Human Resources Department at (609)
495-0512 should you need assistance in scheduling you drug screen.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As an employee of Kos Pharmaceuticals, Inc., you will be an at-will employee, and your
employment is for an indefinite period to time and may be terminated by you, or the Company, at
any time, for any reason.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;On
behalf of both Mike Jaharis, Dan Bell and the Kos Leadership Team, we are genuinely pleased
about your becoming a key member of senior management at Kos. We have much to do and our future is
very bright, as we continue &#147;<B><I>Pioneering Medicines for a
Better Life&#148;</I></B>. I look forward to forming a
strong working relationship with you and to all of the contributions that I know you will bring to
Kos &#151; a Company that is the sixth fastest growing Company in the USA.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt">Cordinally,
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">/s/ Adrian Adams<BR>
</div>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Adrian Adams<BR>
President and CEO

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<DIV align="left" style="font-size: 10pt; margin-top: 12pt">AA/ova
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">cc: Susan E. Taylor
</DIV>



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