MICROMET, INC.
EX-10.48
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<TYPE>EX-10.48
<SEQUENCE>27
<FILENAME>w31794exv10w48.htm
<DESCRIPTION>EX-10.48
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<DIV align="right" style="font-size: 10pt; margin-top: 12pt"><B>Exhibit&nbsp;10.48</B>
</DIV>


<DIV align="right" style="font-size: 10pt; margin-top: 12pt"><B>***Text Omitted and Filed Separately<BR>
Confidential Treatment Requested<BR>
Under 17 C.F.R. &#167;&#167; 200.80(b)(4) and 240.24b-2</B>
</DIV>

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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Tarcanta, Inc.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">2110 Rutherford Road</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Carlsbad, CA 92008</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">USA</TD>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">CIMAB S.A.<BR>
Calle 206, No.&nbsp;1926, e/19 y 21<BR>
Atabey, Playa<BR>
Cuidad de La Habana<BR>
Cuba<BR>
Attn. Norkis Arteaga Morales

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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October&nbsp;6, 2006</TD>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><B>EFG Vaccine License, Development, Manufacturing and Supply Agreement by and between Tarcanta, Inc.,
Tarcanta Ltd., (together, &#147;Tarcanta&#148;) and CIMAB S.A. dated July&nbsp;13, 2004 (the &#147;EGF Agreement&#148;)</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Dear Norkis:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">This letter amends certain provisions of the EGF Agreement. Except as otherwise set forth herein,
the EGF Agreement remains in full force and effect.
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">1.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Tarcanta, Inc. (acting through its parent company Micromet, Inc.) and CIMAB will prepare a
partnering package for non-confidential disclosures and for confidential disclosures to be
used in Tarcanta&#146;s efforts to find a new partner, as set forth in paragraph 2 below. Nothing
in this letter or in the use of the term &#147;partner&#148; amends the EGF Agreement so as to allow any
party to enter relationships or agreements that are in violation of the EGF Agreement as in
effect prior to the execution of this letter. No confidential disclosures will be made unless
the receiving party has executed a confidentiality agreement substantially in the form
attached hereto.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">2.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Tarcanta, Inc. (acting through its parent company Micromet, Inc.) will take the lead in
identifying potential partners and conducting discussions and negotiations regarding a
potential agreement under which a new partner obtains the rights to develop and commercialize
products pursuant the EGF Agreement. Tarcanta, Inc. will use commercially reasonable efforts
to find a mutually acceptable new partner. The terms of any agreement with a new partner will
not violate any of the requirements set forth in the EGF Agreement.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">3.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>CIMAB will support the aforesaid partnering efforts by reasonably making available its staff
and staff from the Centro de Inmunologia Molecular for presentations to potential partners and
for due diligence activities by potential partners, with each side bearing its own costs
except for travel and lodging expenses for CIMAB and CIM staff for travel outside of Cuba,
which costs will be born by Tarcanta.</TD>
</TR>

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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">4.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Tarcanta, Inc. and Tarcanta, Ltd. agree to pay the quarterly Access Fee payments $&#091;***&#093;
currently due and any quarterly Access Fee payments that may become due in the future) in
accordance with the terms of the EGF Agreement.</TD>
</TR>

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</DIV>

<DIV style="margin-top: 6pt">
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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">5.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Tarcanta, Inc. and Tarcanta, Ltd. agree to pay the third $&#091;***&#093; milestone payment set forth
in Article&nbsp;5.1.2 of the EGF Agreement, which Tarcanta acknowledges to be due and owing because
of the transfer by CIMAB and acceptance by Tarcanta of the biological materials comprising the
Transferred Assets no later than the earlier to occur of (1)&nbsp;the closing of a transaction in
which a new partner obtains the rights to develop and commercialize the products pursuant to
the EGF Agreement, and (2)&nbsp;June&nbsp;12, 2007. The payment will include interest of &#091;***&#093;% per
month from June&nbsp;13, 2006.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">6.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>If one or more potential partners have been identified and negotiations on a term sheet or
agreement are ongoing by December&nbsp;31, 2006, the parties will attempt to complete such
negotiations as soon as practicable and effect the transfer of the programs to the new partner
subject to any approvals or consents required by the Office of Foreign Assets Control of the
US Department of the Treasury. If no agreement with a new partner has been executed and no
such negotiations are ongoing by December&nbsp;31, 2006, the parties will discuss how best to
transfer all data and information related to the research and clinical development programs,
to the extent permitted under the license issued by the US Office for Foreign Assets Control
or applicable law or regulation, back to CIMAB, and the EGF Agreement will terminate as of
December&nbsp;31, 2006, subject to the provisions of Articles 12.6, 12.7 and 12.8 of the EGF
Agreement, and paragraphs 4 and 5 hereof, unless the parties agree in writing to extend the
term of the EGF Agreement. Upon termination, Tarcanta Inc. agrees to use best efforts to
instruct patent attorney (i)&nbsp;to transfer all patents and patent applications related to or
embracing technology licensed under the EGF Agreement to CIMAB, and (ii)&nbsp;to promptly execute
all documents, including assignment documents, to accomplish such transfer, to the extent
permitted under the license issued by the US Office for Foreign Assets Control or applicable
law or regulation.</TD>
</TR>

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</DIV>

<DIV style="margin-top: 6pt">
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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">7.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The parties acknowledge and agree that, provided Tarcanta Inc. and Tarcanta, Ltd. perform in
accordance with paragraphs 4, 5 and 6 herein, the obligations of Tarcanta, Inc. and Tarcanta
Ltd. to develop and market products under the EGF Agreement are replaced by the obligation to
undertake the business development activities described in paragraphs 1 and 2 of this letter.
Without limiting the generality of the foregoing, CIMAB, Tarcanta, Inc. and Tarcanta Ltd. will
have no further obligations under Article&nbsp;3 (except Sections&nbsp;3.9 and 3.10), Article&nbsp;4, and
Section&nbsp;9.1(d) of the EGF Agreement, and, provided that Tarcanta Inc. and Tarcanta, Ltd. are
not in breach of paragraphs 4 and 5 herein, CIMAB will not have the right to terminate the EGF
Agreement pursuant to Section&nbsp;12.4 of the EGF Agreement, during the period of &#091;***&#093; from the
execution of this letter, unless the parties agree in writing to extend the aforementioned
period.</TD>
</TR>

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</DIV>

<DIV style="margin-top: 6pt">
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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">8.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The parties acknowledge and agree that provided Tarcanta, Inc. and Tarcanta Ltd. perform in
accordance with Articles 4, and 5 herein, they will have no further obligations to make
payments to CIMAB under the EGF Agreement except as set forth in paragraphs 4 and 5 herein,
unless and until Tarcanta, Inc. and Tarcanta Ltd. have entered into a sublicense agreement as
contemplated in Section&nbsp;2.2 of the EGF Agreement, in which case Tarcanta, Inc. or Tarcanta
Ltd. will make the applicable payments set forth in Article&nbsp;5 of the EGF</TD>
</TR>

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</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

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    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
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<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and
filed separately with the Commission. Confidential treatment has been requested
with respect to the omitted portions.</TD>
</TR>

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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Agreement due in connection with the execution of such sublicense agreement and the development
and commercialization of the products pursuant to the EGF Agreement by the applicable
sublicensee. If neither a sublicense is entered, nor the EGF Agreement terminated, by June&nbsp;13,
2007, the obligations to make payments set forth in Article&nbsp;5 of the EGF Agreement will remain
in effect.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">9.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>CIMAB S.A. hereby withdraws any allegations of breach of contract by Tarcanta, Inc. and
Tarcanta Ltd., without prejudice to reassertion of same if Tarcanta fails to perform its
obligations herein. Without limiting the generality of the foregoing, CIMAB acknowledges and
agrees that by performing their obligations herein Tarcanta, Inc. and Tarcanta Ltd. will have
cured any potential breaches of the EGF Agreement alleged in letters from CIMAB on January&nbsp;13,
2006 and April&nbsp;21, 2006, and that Tarcanta, Inc. and Tarcanta Ltd. are licensees in good
standing and in full compliance with their obligations under the EGF Agreement. The previous
is without prejudice to CIMAB&#146;s ability and right to put Tarcanta Inc. and Tarcanta, Ltd. on
notice of currently unknown or future breaches of the provisions herein or the EGF Agreement,
or to seek redress thereof, with such disputes to be governed by Article&nbsp;14 of the EGF
Agreement.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">10.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Tarcanta, Inc., and Tarcanta Ltd. specifically waive and withdraw any allegations of breach
of the EGF Agreement by CIMAB that are known to Tarcanta, Inc., Tarcanta, Ltd. or any of their
affiliates as of the date of this letter. The previous is without prejudice to their ability
and right to put CIMAB on notice of currently unknown or future breaches of the provisions of
this letter or the EGF Agreement, or to seek redress thereof, with such disputes to be
governed by Article&nbsp;14 of the EGF Agreement.</TD>
</TR>

</TABLE>
</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Please confirm your agreement with the above provisions by signing and returning an original copy
of this letter to the undersigned.
</DIV>

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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Sincerely,</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Tarcanta, Inc.
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Tarcanta Ltd.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">By: /s/ Christian Itin
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By: /s/ Christian Itin</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Name: Christian Itin, Ph.D.
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Name: Christian Itin, Ph.D.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Title: President and CEO
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Title: President and CEO</TD>
</TR>
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</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Acknowledged and agreed:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">CIMAB S.A.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">By: /s/ Norkis Arteaga<BR>
Name: Norkis Arteaga MSC.<BR>
Title: General Manager

</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Date: 24/10/2006
</DIV>


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<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CONFIDENTIALITY AGREEMENT</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">This Confidentiality Agreement (the &#147;<B>Agreement</B>&#148;) is made effective as of &#95;&#95;&#95;, 2006 (the
&#147;<B>Effective Date</B>&#148;), by and between &#091;&#95;&#95;&#95;&#093; (&#147;<B>&#091;Company Name&#093;</B>&#148;), and Micromet, Inc.,
2110 Rutherford Road, Carlsbad, CA 92008, USA (&#147;<B>Micromet</B>&#148;), and each of Micromet and &#091;Company Name&#093;
hereafter individually referred to as &#147;<B>Party</B>&#148; or collectively as &#147;<B>Parties</B>&#148;).
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>RECITALS</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A.&nbsp;Micromet is interested in discussing a potential business relationship with &#091;Company Name&#093;
with respect to SAI-EGF, SAI-TGF and related products.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B.&nbsp;This Agreement is intended to allow the Parties to enter into such discussions while
protecting such Confidential Information (including Confidential Information disclosed prior to the
Effective Date) against unauthorized use or disclosure.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In consideration of the foregoing premises, the mutual promises and covenants set forth in
this Agreement, and other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the Parties hereby agree as follows:
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>AGREEMENT</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>1.&nbsp;Definitions</B>. As used in this Agreement, the terms set forth below have the following
meanings:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>a. </B>&#147;<B>Confidential Information</B>&#148; shall mean all information, including, but not limited to,
procedures, developments, results, data, conclusions, technologies, inventions and the like,
related to SAI-EGF, SAI-TGF, SAI Her-1 and related products disclosed to &#091;Company Name&#093; and
technologies, know-how, processes, manufacturing information and the like related to &#091;Company Name&#093;
disclosed to Micromet, (a)&nbsp;in written form marked &#147;confidential&#148;, and (b)&nbsp;in oral or visual form if
summarized in a writing marked &#147;confidential&#148; delivered to the Receiving Party within thirty (30)
days after the oral or visual disclosure.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>b. </B>&#147;<B>Disclosing Party</B>&#148; means the Party disclosing Confidential Information to the other Party.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>c. </B>&#147;<B>Receiving Party</B>&#148; means the Party receiving Confidential Information from the other Party.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>2.&nbsp;Purpose</B>. Any disclosure of Confidential Information by one Party to the other Party is made
solely for the purpose of advancing the Parties&#146; discussions relating to their interest in entering
into a business relationship for the evaluation, testing, development and commercialization of one
or more of Micromet&#146;s proprietary pharmaceutical products (the &#147;<B>Purpose</B>&#148;).
</DIV>

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<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>3. Confidentiality and Use Restrictions.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>a. </B>The Receiving Party shall maintain the Confidential Information received from the
Disclosing Party in confidence and shall not disclose such information to any third party. The
Receiving Party shall use such Confidential Information solely for the Purpose, unless otherwise
mutually agreed in writing. Upon request by the Disclosing Party, the Receiving Party shall return
all such Confidential Information, including any documents, notes and other tangible materials
comprising such Confidential Information and all copies thereof, except that one (1)&nbsp;copy of the
written materials may be retained by the Receiving Party for purposes of verifying compliance with
this Agreement.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>b. </B>The Receiving Party shall confine the dissemination of Confidential Information received
from the Disclosing Party only to those individuals within its organization, its affiliated
organizations or its consultants who have a need to evaluate the information for the Purpose and
who are bound to obligations of confidentiality and non-use at least as strict as those contained
herein.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>4.&nbsp;Exceptions</B>. The Receiving Party&#146;s obligations hereunder shall not apply to any part of the
Confidential Information received from the Disclosing Party which: (a)&nbsp;is or becomes part of the
public domain or otherwise generally available to the public other than through breach of this
Agreement by the Receiving Party, or by any person or entity bound by the Agreement by virtue of
paragraph 3b herein, or otherwise; (b)&nbsp;is received by the Receiving Party in good faith without
disclosure or use restrictions from any third party; (c)&nbsp;is known to the Receiving Party prior to
the disclosure by the Disclosing Party, as evidenced by contemporaneous written record; or (d)&nbsp;is
independently developed by the Receiving Party with personnel who did not have knowledge of or
access to Confidential Information received from the Disclosing Party, as evidenced by
contemporaneous written record.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>5.&nbsp;Authorized Disclosure</B>. Notwithstanding the terms set forth in Section&nbsp;3, the Receiving
Party may disclose Confidential Information received from the Disclosing Party to the extent that
such disclosure is made in response to a valid order of a court of competent jurisdiction or other
governmental or regulatory body of competent jurisdiction; <I>provided, however, </I>that the Receiving
Party shall as soon as practicable give notice to the Disclosing Party and if practicable give the
Disclosing Party a reasonable opportunity to quash such order and to obtain a protective order
requiring that such Confidential Information and documents that are the subject of such order be
held in confidence by such court or governmental or regulatory body or, if disclosed, be used only
for the purposes for which the order was issued; and <I>provided, further, </I>that if a disclosure order
is not quashed or a protective order is not obtained, such Confidential Information disclosed in
response to such court or governmental order will be limited to information that is legally
required to be disclosed in response to such court or governmental order.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>6.&nbsp;Right to Disclose</B>. Micromet represents and warrants that the Confidential Information
disclosed by it to the Receiving Party is the property of Micromet, Tarcanta, Inc. or Tarcanta,
Ltd, or of third-parties that have authorized Micromet to disclose same pursuant to this Agreement,
and that the disclosure thereof to the Receiving Party does not violate the rights of any third
party. The other Party to this Agreement represents and warrants that the Confidential Information
disclosed to the Receiving Party is the property of the other Party to this Agreement and that the
disclosure thereof to the Receiving Party does not violate the rights of any third party. Nothing
in this Agreement shall be construed as a license or grant of any patent or other rights in or to
such Confidential Information by the Disclosing Party to the Receiving Party.
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>7.&nbsp;Term</B>. This Agreement and the Receiving Party&#146;s obligations herein shall remain in effect
for a period of &#091;***&#093; from the Effective Date.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>8.&nbsp;Assignment</B>. This Agreement may not be assigned or transferred without the prior written
consent of both Parties, which consent shall not be unreasonably withheld; <I>provided, however, </I>that
either Party may assign this Agreement to any person or entity which acquires all or substantially
all of its business or assets (or of the business division or product line of such party to which
the Confidential Information and/or Purpose primarily relates).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.&nbsp;Entire Agreement; Modification</B>. This Agreement is the entire agreement between the Parties
with respect to the subject matter hereof. This Agreement may not be amended, modified or released
except by a written instrument signed by an authorized representative of each Party.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>10.&nbsp;Dispute Resolution and Governing Law</B>. This Agreement shall be governed by and shall be
construed in accordance with the laws of England without reference to its conflict of laws
provisions. The Parties agree that they shall in good faith work towards implementation of this
Agreement and any dispute arising out of or in relation to this Agreement shall be first attempted
to be resolved amicably by mutual negotiations, failing which such dispute shall be referred to
Arbitration to be conducted in accordance with the International Chamber of Commerce Rules of
Arbitration then in effect. The arbitration shall be held in London, United Kingdom and shall be
conducted in English by one arbitrator, appointed by both the Parties in accordance with said
Rules. The decision of such arbitrator shall be final, binding and conclusive on the Parties, and
judgment thereon may be entered in any court having jurisdiction over the Parties and the subject
matter hereof.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>11.&nbsp;</B>In addition to being for the benefit of parties to this Agreement, it is agreed that the
Agreement is for the benefit of third-parties which have authorized Micromet to make disclosure of
their Confidential Information pursuant to this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>12.&nbsp;</B>IN WITNESS WHEREOF, the Parties hereto have caused this Agreement to be executed by their
duly authorized representatives.
</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="10%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="10%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left"><B>&#091;COMPANY NAME&#093;</B></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" valign="top" align="left"><B>MICROMET, INC.</B></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">By:
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="bottom"><DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="bottom"><DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left">Name:</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Jens Hennecke, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left">Title:</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">VP Business Development</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">***</TD>
    <TD>&nbsp;</TD>
    <TD>Certain information on this page has been omitted and
filed separately with the Commission. Confidential treatment has been requested
with respect to the omitted portions.</TD>
</TR>

</TABLE>




<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>





<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>


<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV align="right" style="font-size: 10pt; margin-top: 12pt"><B>Exhibit&nbsp;10.48</B>
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="60%">&nbsp;</TD>
    <TD width="20%">&nbsp;</TD>
    <TD width="20%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Tarcanta, Inc.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">2110 Rutherford Road</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Carlsbad, CA 92008</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">USA</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">CIMAB S.A.<BR>
Calle 206, No.&nbsp;1926, e/19 y 21<BR>
Atabey, Playa<BR>
Cuidad de La Habana<BR>
Cuba<BR>
Attn. Norkis Arteaga Morales

</DIV>

<DIV align="right" style="font-size: 10pt; margin-top: 12pt">December&nbsp;20, 2006
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><B>EGF Vaccine License, Development, Manufacturing and Supply Agreement by and between Tarcanta, Inc.,
Tarcanta Ltd., (together, &#147;Tarcanta&#148;), and CIMAB S.A. dated July&nbsp;13, 2004 (the &#147;EGF Agreement&#148;)</B>
</DIV>






<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><B>TGF-<FONT style="font-family: symbol">&#097;</FONT> / HER-1 Vaccine License, Development, Manufacturing and Supply Agreement by and between
Tarcanta, Inc., Tarcanta Ltd., (together, &#147;Tarcanta&#148;), CIMAB S.A. (&#147;CIMAB&#148;), YM Biosciences, Inc.
and CIMYM, Inc. dated July&nbsp;13, 2004 (the &#147;TGF /HER-1 Agreement&#148;)</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Dear Norkis:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Per our email correspondence, we are currently in discussions with two potential partners who have
an interest in obtaining rights to the above referenced vaccine programs. In order to enable us to
complete the discussions, we kindly request that you confirm your agreement with amending the
letter agreements dated October&nbsp;6, 2006, by replacing &#147;December&nbsp;31, 2006&#148; wherever such date
appears in Section&nbsp;6 and Section&nbsp;4, respectively, with &#147;February&nbsp;28, 2007.&#148;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Please confirm your agreement by signing and returning an original copy of this letter to the
undersigned.
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="10%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="10%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left">Sincerely,</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left"><FONT style="font-variant: SMALL-CAPS"><B>Tarcanta, Inc.</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" valign="top" align="left"><FONT style="font-variant: SMALL-CAPS"><B>Tarcanta Ltd.</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">By:
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">/s/ Christian Itin
<DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">/s/ Christian Itin
<DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left">Name: Christian Itin, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" valign="top" align="left">Name: Christian Itin, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left">Title: President and CEO</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" valign="top" align="left">Title: President and CEO</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left">Acknowledged and agreed:</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left"><FONT style="font-variant: SMALL-CAPS"><B>CIMAB S.A.</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">By:
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">/s/ Noakis Arteaga
<DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left">Name: Noakis Arteaga, MSC</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left">Title: General Manager</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD colspan="3" valign="top" align="left">Date: January&nbsp;11<SUP style="font-size: 85%; vertical-align: text-top">th</SUP>, 2006</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt"><!-- Folio --><!-- /Folio -->
</DIV>


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</HTML>
</TEXT>
</DOCUMENT>
