CANCERVAX CORP
EXHIBIT 10.1
<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>2
<FILENAME>a19985exv10w1.htm
<DESCRIPTION>EXHIBIT 10.1
<TEXT>
<HTML>
<HEAD>
<TITLE>exv10w1</TITLE>
</HEAD>
<BODY bgcolor="#FFFFFF">
<!-- PAGEBREAK -->
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">





<DIV align="right" style="font-size: 10pt; margin-top: 12pt"><B>Exhibit&nbsp;10.1</B>
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SUBLEASE AGREEMENT</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Sublease Agreement (&#147;<U>Sublease</U>&#148;) is made as of the 26th day of April, 2006, by and
between CancerVax Corporation, a Delaware corporation (&#147;<U>Sublandlord</U>&#148;), and Genoptix, Inc.,
a Delaware corporation (&#147;<U>Subtenant</U>&#148;).
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>RECITALS</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Sublease is made with regard to the following facts:
</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">A. Sublandlord is the tenant under that certain Standard Industrial/Commercial Single-Tenant
Lease-Net dated August&nbsp;31, 2001 (the &#147;<U>Original Lease</U>&#148;), with Blackmore Airport Centre, a
California limited partnership (the &#147;<U>Master Landlord</U>&#148;), as amended by that certain
Amendment of Lease dated August&nbsp;16, 2002 (&#147;<U>First Amendment</U>&#148;), and that certain Amendment of
Lease dated May&nbsp;24, 2004 (&#147;<U>Second Amendment</U>,&#148; and the Original Lease as amended by the
First Amendment and the Second Amendment, the &#147;<U>Master Lease</U>&#148;). A copy of the Master Lease
is attached as <U>Exhibit&nbsp;A</U> hereto.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">B. Section&nbsp;1.2 of the Master Lease provides that the entire square footage of the building (the
&#147;<U>Building</U>&#148;) located at 2110 Rutherford Road, Carlsbad, California, and leased by
Sublandlord is approximately 57,365 square feet of space. Sublandlord constructed additional
improvements on the second floor of the Building which resulted in an increase in the rentable
square footage of the Building leased by Sublandlord to approximately 61,618 rentable square feet
of space (the &#147;<U>Premises</U>&#148;).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">C. Subtenant desires to sublease from Sublandlord a portion of the Premises (the &#147;<U>Subleased
Premises</U>&#148;), which Subleased Premises are more particularly described in <U>Exhibit&nbsp;B</U>
attached to this Sublease. Sublandlord has agreed to sublease the Subleased Premises to Subtenant
on the terms, covenants and conditions stated in this Sublease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NOW, THEREFORE, in consideration of the mutual covenants contained in this Sublease, and for
valuable consideration, the receipt and sufficiency of which are acknowledged by the parties, the
parties agree as follows:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>1.&nbsp;Sublease</B>. Sublandlord subleases to Subtenant and Subtenant subleases from Sublandlord the
Subleased Premises, subject to the terms, covenants, and conditions contained in this Sublease.
Sublandlord and Subtenant agree that the Subleased Premises contain 46,527 rentable square feet of
space on the ground floor of the Building.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>2.&nbsp;Term</B>. Subject to the condition set forth in Section&nbsp;14.6 below, the terms and provisions
of this Sublease shall be effective between Sublandlord and Subtenant as of the date of mutual
execution of this Sublease. The term of this Sublease (the &#147;<U>Term</U>&#148;) will commence on May&nbsp;1,
2006 (the &#147;<U>Sublease Commencement Date</U>&#148;) and will expire, unless sooner terminated as
provided in the Master Lease, on June&nbsp;30, 2012 (the &#147;<U>Expiration Date</U>&#148;). In no event
shall the Expiration Date of the Sublease exceed the termination date of the Master Lease.
</DIV>

<P align="center" style="font-size: 10pt">1
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>3.&nbsp;Base Rent</B>. Subtenant will pay monthly base rent (&#147;<U>Base Rent</U>&#148;) for the Subleased
Premises during the Term in the amount set forth in <U>Exhibit&nbsp;C</U> attached hereto. Upon
execution of this Sublease, Subtenant shall pay Base Rent for August&nbsp;2006 to Sublandlord.
Furthermore, in the event that the Term begins or ends on a date that is not the first day of a
month, Base Rent will be prorated as of that date. Notwithstanding anything in this Section&nbsp;3,
Subtenant shall not be required to pay Base Rent for the months of May&nbsp;2006, June&nbsp;2006 and July
2006, but shall pay all other amounts required to be paid by Subtenant hereunder.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>3.1 Security Deposit</B>. Subtenant shall furnish Sublandlord with an irrevocable standby letter
of credit (&#147;<U>Letter of Credit</U>&#148;) in a form reasonably acceptable to Sublandlord and Comerica
Bank, naming Sublandlord, as beneficiary, from Comerica Bank or other institution reasonably
acceptable to Sublandlord (&#147;<U>Bank</U>&#148;) (which institution shall be acceptable to Sublandlord if
Sublandlord determines it is a bank of the size and quality of Comerica Bank), in the original
amount of Four Hundred Fifty Thousand and 00/100 Dollars ($450,000.00) to be used by Sublandlord as
a security deposit to secure Subtenant&#146;s faithful performance of all terms, provisions and
conditions of this Sublease. Each Letter of Credit shall: (a)&nbsp;have an initial term of at least one
hundred twenty (120)&nbsp;days; (b)&nbsp;be drawable upon presentation of a sight draft at the Bank&#146;s office
located in San Diego, California; (c)&nbsp;be transferable at Sublandlord&#146;s election to any successor of
Sublandlord at Subtenant&#146;s sole cost; and (d)&nbsp;permit partial draws and multiple presentations.
Subtenant shall furnish the Letter of Credit to Sublandlord within five (5)&nbsp;business days of the
full execution of this Sublease. Subtenant may replace the Letter of Credit at any time with
another letter of credit that satisfies all of the requirements for the Letter of Credit.
Subtenant shall so replace each Letter of Credit at least thirty (30)&nbsp;days before its date of
expiration (as it may have been extended), unless such date of expiration will occur at least sixty
(60)&nbsp;days after the Expiration Date, in which case Subtenant shall have no obligation to replace
such Letter Credit. Sublandlord may draw upon a Letter of Credit if (x)&nbsp;Subtenant files a
voluntary petition in bankruptcy, or an involuntary petition in bankruptcy is filed against
Subtenant that is not dismissed within sixty (60)&nbsp;days of such filing, or (y)&nbsp;before the thirtieth
(30th) day after the Expiration Date, the Letter of Credit is due to expire within thirty (30)&nbsp;days
(after taking into account any extension of the Letter of Credit that may have then occurred).
Upon any default under the Sublease after expiration of the applicable cure periods, Sublandlord
shall be permitted to draw upon the Letter of Credit and use the proceeds of the Letter of Credit
on the same terms and provisions of Paragraph&nbsp;5 of the Master Lease; <I>provided, however, </I>that
Sublandlord shall only draw down such amounts that do not exceed Sublandlord&#146;s good faith estimate
of the sum of (a)&nbsp;damages suffered by Sublandlord because of such default and (b)&nbsp;the cost to cure
such default.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If Sublandlord draws upon the Letter of Credit, then within fifteen (15)&nbsp;days following
Sublandlord&#146;s written request therefor, Subtenant shall replace the Letter of Credit with a new
letter of credit which meets the criteria of the Letter of Credit under this Section&nbsp;3. Upon
receipt of such replacement Letter of Credit from Subtenant, Sublandlord shall promptly refund to
Subtenant any amounts drawn under the former Letter of Credit that exceed amounts used to cure
Subtenant&#146;s default and the amount of damages Sublandlord suffered because of such default under
the Sublease.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Sublandlord and Subtenant acknowledge that the required amount of the Letter of Credit will be
reduced during the Term of the Sublease, and so long as Subtenant is not then, and during
</DIV>

<P align="center" style="font-size: 10pt">2
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">the
previous twelve (12)&nbsp;month period, has not been, in default under this Sublease beyond applicable
notice and cure periods, the required amount of the Letter of Credit (and total required security
deposit) shall be reduced as follows:
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">1.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>On June&nbsp;30, 2008, the required Letter of Credit amount shall be reduced
to Three Hundred Sixty Thousand and 00/100 Dollars ($360,000.00);</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">2.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>On June&nbsp;30, 2009, the required Letter of Credit amount shall be reduced
to Two Hundred Seventy Thousand and 00/100 Dollars ($270,000.00);</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">3.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>On June&nbsp;30, 2010, the required Letter of Credit amount shall be reduced
to One Hundred Eighty Thousand and 00/100 Dollars ($180,000.00); and</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">4.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>On June&nbsp;30, 2011, the required Letter of Credit amount shall be reduced
to Ninety Thousand and 00/100 Dollars ($90,000.00).</TD>
</TR>

</TABLE>
</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">If the amount of the Letter of Credit is to be reduced, then Sublandlord shall, at Subtenant&#146;s sole
cost and expense, extend reasonable cooperation and execute such reasonable and customary documents
as the Bank may require in issuing any modified or replacement Letter of Credit, and shall return
the Letter of Credit it then holds promptly after it receives the replacement Letter of Credit in
the reduced amount.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>4.&nbsp;Reimbursable Expenses</B>. Subtenant shall pay to Sublandlord, as additional rent, seventy-six
percent (76%) (&#147;<U>Subtenant&#146;s Pro Rata Share</U>&#148;) of the Reimbursable Expenses (as defined
below) incurred by Sublandlord during the Term of the Sublease. Subtenant&#146;s Pro Rata Share is
determined by dividing 46,527 rentable square feet of the Subleased Premises by the 61,618 rentable
square feet of the Premises. Subject to Section&nbsp;4.2, &#147;<U>Reimbursable Expenses</U>&#148; means and
includes all expenses incurred by Sublandlord in the operation or maintenance of the Building,
including all amounts Sublandlord is required to pay to Master Landlord under Sections&nbsp;8, 10, 11
and 52 of the Master Lease, and including (i)&nbsp;real property taxes; (ii)&nbsp;real property, liability,
personal property and business interruption insurance; (iii)&nbsp;landscape maintenance costs; (iv)
common area maintenance fees (including, but not limited to, the costs of water, gas, electricity
and telephone service to the Building, maintenance of and improvements to parking areas, loading
and unloading areas, trash areas, roadways, parkways, walkways, driveways, lighting facilities,
fences and gates, trash disposal, pest control services, property management, security services and
the costs of any environmental inspections); (v)&nbsp;all costs of maintaining and repairing the
Building; (vi)&nbsp;costs of maintaining, operating or repairing the Building&#146;s mechanical, electrical
and other systems, including the Building&#146;s heating, ventilation and air conditioning system
(&#147;<U>HVAC System</U>&#148;); (vii)&nbsp;costs of fire sprinkler maintenance; monitoring, testing and
certification; (viii)&nbsp;costs of roof inspections, repair and maintenance; (ix)&nbsp;concrete sealer
maintenance costs; (x)&nbsp;fossil filter maintenance costs; (xi)&nbsp;backflow maintenance costs; (xii)
window washing costs; (xiii)&nbsp;janitorial costs; and (xiv)&nbsp;internal and external Building structure,
maintenance and repair costs. Any costs that are specifically attributable to or incurred
at the request of or for the benefit of, a specific tenant of the Building shall be allocated
entirely to such tenant and shall be excluded from Reimbursable Expenses, and Subtenant shall have
no obligation to pay any such amounts. However, Subtenant shall pay
</DIV>

<P align="center" style="font-size: 10pt">3
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Subtenant&#146;s Pro Rata Share of
any Reimbursable Expenses which are not specifically attributable to a specific tenant to
Sublandlord.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>4.1 Partial Building Occupation</B>. If the occupancy of the Building during any part of the
Term of this Sublease is less than ninety-five percent (95%), Sublandlord shall make an appropriate
adjustment of the variable components of the Reimbursable Expenses during that time period, as
reasonably determined by Sublandlord using sound accounting and management principles, to determine
the amount of Reimbursable Expenses that would have been incurred had the Building been ninety-five
percent (95%) occupied. This amount shall be considered to have been the amount of operating
expenses for such time period. For purposes of this Section&nbsp;4, variable components include only
those components that are affected by variations in occupancy levels.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>4.2 Exclusions from Reimbursable Expenses</B>. Despite any other provisions of this Section&nbsp;4,
and notwithstanding any provision in this Sublease to the contrary, Reimbursable Expenses shall not
include the following: (i)&nbsp;depreciation, amortization or interest payments, and interest,
principal, points and fees on debts or amortization on any mortgage or mortgages or any other debt
instrument encumbering the Building; (ii)&nbsp;payments of base rent under the Master Lease; (iii)&nbsp;legal
fees incurred in negotiating and enforcing tenant leases, and any in-house legal or accounting
fees; (iv)&nbsp;advertising and marketing costs, including, without limitation, real estate brokers&#146;
leasing commissions, attorneys&#146; fees in connection with the negotiation and preparation of letters,
deal memos, letters of intent, leases, subleases and/or assignments, space planning costs, and
other costs and expenses incurred in connection with lease, sublease and/or assignment negotiations
and transactions with present or prospective tenants, subtenant or other occupants of the Building;
(v)&nbsp;improvements or alterations to tenant spaces or any costs incurred in renovating or otherwise
improving, decorating, painting or redecorating vacant space for tenants, subtenants or other
occupants of the Building; (vi)&nbsp;the cost of providing any service directly to and paid directly by
any tenant; (vii)&nbsp;any costs expressly excluded from Reimbursable Expenses elsewhere in this
Sublease; (viii)&nbsp;costs of capital improvements, except for costs incurred in connection with the
Building that are (a)&nbsp;intended as a labor-saving device or to effect other economies in the
maintenance or operation of, or stability of services to, all or part of the Building, or (b)&nbsp;are
required under any government law or regulation but that were not required in connection with the
Building when permits for the construction of the Building were obtained, and all such costs shall
be amortized over the useful life of the capital improvement in accordance with generally accepted
accounting principles; (ix)&nbsp;any ground lease rental; (x)&nbsp;costs incurred by Sublandlord for the
repair of damage to the Building, to the extent that Sublandlord is reimbursed by insurance
proceeds; (xi)&nbsp;expenses in connection with services or other benefits which are not offered to or
provided to Subtenant and which are offered or provided to another tenant or occupant of the
Building; (xii)&nbsp;costs incurred by Sublandlord due to the negligent or intentional violation by
Sublandlord of the Master Lease unless caused by Subtenant; (xiii)&nbsp;costs incurred in connection
with upgrading the Building (but not the Premises) to comply with disability, life, fire and safety
codes, ordinances, statutes, or other laws in effect prior to the Commencement Date, including, without limitation, the Americans with Disabilities Act,
including penalties or damages incurred due to such non-compliance; (xiv)&nbsp;tax penalties incurred as
a result of Sublandlord&#146;s negligence, inability or unwillingness to make payments and/or to file
any tax or informational returns when due; (xv)&nbsp;any management fees in excess of those management
fees which are normally and customarily
</DIV>


<P align="center" style="font-size: 10pt">4
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">charged by landlords of buildings which are located in the
vicinity of and are comparable to the Building (&#147;<U>Comparable Buildings</U>&#148;); (xvi)&nbsp;costs
arising from the negligence or fault of other tenants or Sublandlord or its agents, or any vendors,
contractors, or providers of materials or services selected, hired or engaged by Sublandlord or its
agents; and (xvii)&nbsp;notwithstanding any contrary provision of the Sublease, including, without
limitation, any provision relating to capital expenditures, any and all costs arising from the
presence on the date hereof of hazardous materials or substances (as defined by applicable laws in
effect on the date the Sublease is executed) in or about the Subleased Premises or the Building,
including, without limitation, Hazardous Substances in the ground water or soil, not placed on the
Premises or in the Building by Subtenant; and (xviii)&nbsp;costs arising from latent defects in the
base, shell or core of the Building of which Sublandlord is aware on the date hereof.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>4.3 Payment of Reimbursable Expenses. </B>Subtenant shall pay to Sublandlord: (a)&nbsp;Subtenant&#146;s Pro
Rata Share of Reimbursable Expenses at least three (3)&nbsp;business days prior to the date Sublandlord
must pay Sublandlord&#146;s share to the Master Landlord pursuant to the terms of the Master Lease if
the Master Lease requires Sublandlord to pay such amount to the Master Landlord, provided that
Sublandlord shall have delivered a statement of estimated or actual Subtenant&#146;s Pro Rata Share to
Subtenant; and (b)&nbsp;within ten (10)&nbsp;days after the Sublandlord presents a reasonably detailed
statement of actual expenses to Subtenant for all other Reimbursable Expenses. At Subtenant&#146;s
reasonable request, Sublandlord shall provide Subtenant with additional documentation relating to
the actual Reimbursable Expenses set out in such statement. At Sublandlord&#146;s option, however, an
amount may be estimated by Sublandlord from time to time of Subtenant&#146;s actual share of
Reimbursable Expenses and the same shall be payable monthly or quarterly as Sublandlord shall
designate, during each twelve month period of the Term, on the same day as Base Rent is due
hereunder. Sublandlord shall deliver to Subtenant within sixty (60)&nbsp;days after the expiration of
each calendar year a reasonably detailed statement showing Subtenant&#146;s actual share of Reimbursable
Expenses incurred during such calendar year (&#147;<U>Reconciliation Statement</U>&#148;). If Subtenant&#146;s
payments under this Section&nbsp;4 during the preceding year exceed Subtenant&#146;s actual share of the
Reimbursable Expenses incurred during such year as indicated on the Reconciliation Statement,
Sublandlord shall credit the amount of such overpayment against Subtenant&#146;s Pro Rata Share of the
Reimbursable Expenses next becoming due. If Subtenant&#146;s payments under this Section&nbsp;4 during the
preceding year were less than Subtenant&#146;s share as indicated on the Reconciliation Statement,
Subtenant shall pay to Sublandlord the amount of the deficiency within ten (10)&nbsp;days after delivery
by Sublandlord to Subtenant of the Reconciliation Statement. Notwithstanding any provision to the
contrary in this Sublease, in the event that Sublandlord fails to deliver the Reconciliation
Statement within three hundred sixty-five (365)&nbsp;days after the expiration of the applicable
calendar year, including the calendar year in which the Expiration Date or date of earlier
termination of this Sublease falls, Sublandlord shall be conclusively deemed to have waived its
right to recover any amount of deficiency for such calendar year, and in no event shall Subtenant
have any obligation to pay such amount.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>4.4 Audit Right</B>. In the event of any dispute as to any amount due hereunder by Subtenant for
Reimbursable Expenses, Subtenant shall have the right upon reasonable advance written notice to
inspect Sublandlord&#146;s accounting records relative to Reimbursable Expenses at the office in the
building in which Sublandlord maintains its records during normal business hours at any time within
ninety (90)&nbsp;days following the furnishing by Sublandlord to
</DIV>


<P align="center" style="font-size: 10pt">5
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Subtenant of such statement, provided
that such records shall be maintained in the continental United States. Any outside consultant
engaged by Subtenant in connection with such review shall be engaged only on a non-contingency fee
basis and shall be a certified public accountant. If Subtenant objects to Sublandlord&#146;s
calculation by written notice delivered to Sublandlord within such ninety (90)&nbsp;day period, then a
certification as to the proper amount of Reimbursable Expenses shall be made by another independent
Certified Public Accountant mutually agreed upon by the parties, which certification shall be final
and conclusive. Subtenant agrees to pay the cost of such certification unless it is determined
that Sublandlord&#146;s original determination of Reimbursable Expenses was in error by more than five
percent (5%) over Subtenant&#146;s actual obligation, in which case Sublandlord shall pay the cost of
such certification and all of Subtenant&#146;s audit costs.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>5.&nbsp;Right of First Refusal</B>. Subtenant shall have, during the Sublease Term and any extensions
thereof, the continuing right of first refusal (the &#147;<U>Right of First Refusal</U>&#148;), subject to
consent by the Master Landlord, to lease the entire second floor of the Building or portion thereof
for office-related use (the &#147;<U>Second Floor Space</U>&#148;) which Second Floor Space consists of
approximately 15,091 rentable square feet. At such time as Sublandlord receives a bona fide offer
from a third party to lease all or any portion of the Second Floor Space which Sublandlord is
willing to accept, Sublandlord shall provide Subtenant with written notice thereof (the
&#147;<U>Notice</U>&#148;). The Notice shall specify all of the basic economic terms of Sublandlord&#146;s
proposed leasing of the Second Floor Space or portion hereof, including the term, rental rate, any
tenant improvement allowance, free rent periods, any other material financial terms and the portion
of the Second Floor Space to be subleased. Upon receipt of the Notice, Subtenant&#146;s Right of First
Refusal will be triggered and the following provisions shall control Subtenant&#146;s exercise (or
non-exercise) thereof.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>5.1 Procedure</B>. Subtenant shall have five (5)&nbsp;business days from receipt of the Notice during
which to exercise Subtenant&#146;s Right of First Refusal to lease the Second Floor Space (or portion
thereof). Such election may only be made by Subtenant&#146;s delivery of written notice (&#147;<U>Exercise
Notice</U>&#148;) to Sublandlord within such five (5)&nbsp;business day period. Subtenant&#146;s failure to
timely provide the Exercise Notice to the Sublandlord shall constitute Subtenant&#146;s deemed waiver of
Subtenant&#146;s Right of First Refusal, and Sublandlord may thereafter sublease the Second Floor Space
to any prospective tenant, subject to obtaining consent of the Master Landlord, on all of the same
terms as those set forth in the Notice. If no such sublease is executed with a subtenant within
sixty (60)&nbsp;days after the expiration of the five (5)&nbsp;business day period following receipt of the
Notice on the same terms as provided in the Notice, then Subtenant&#146;s Right of First Refusal will be
reinstated on the terms and provisions of this Section&nbsp;5, including reinstatement of Subtenant&#146;s
rights to receive an updated Notice. In the event that Sublandlord timely enters into
a sublease with a third party for less than the entirety of the Second Floor Space,
Subtenant&#146;s Right of First Refusal shall apply to the balance of the Second Floor Space.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>5.2 Exercise</B>. Upon exercise by the Subtenant of Subtenant&#146;s Right of First Refusal pursuant
to delivery of the Exercise Notice, (i)&nbsp;Sublandlord shall use its good faith efforts and
commercially reasonable diligence to obtain the consent of the Master Landlord within thirty (30)
days of delivery of the Exercise Notice, (ii)&nbsp;upon obtaining the consent of the Master Landlord,
Subtenant and Sublandlord shall, within fifteen (15)&nbsp;days after obtaining the
</DIV>



<P align="center" style="font-size: 10pt">6
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Master Landlord&#146;s consent, execute an amendment to this Sublease to include the Second Floor Space as part of the
Subleased Premises, (iii)&nbsp;the rental rate, rent increases, rent commencement, tenant improvement
allowance (if any), and other economic terms and conditions applicable to such additional space
(other than the term) shall be those set forth in the applicable Notice delivered to Subtenant
pursuant to this Section&nbsp;5, and (iv)&nbsp;all of the other terms and conditions of this Sublease shall
apply to the Second Floor Space, as if originally included as part of the Subleased Premises. If
the Sublandlord is unable to obtain the consent of the Master Landlord to the Subtenant&#146;s exercise
of the Right of First Refusal within forty-five (45)&nbsp;days of Subtenant&#146;s exercise of the Right of
First Refusal, then Subtenant&#146;s exercise of the Right of First Refusal shall be deemed null and
void, and the Sublandlord may thereafter sublease the Second Floor Space to any prospective
subtenant on the same terms and conditions on which the Sublandlord could have offered the Second
Floor Space if Subtenant had not exercised Subtenant&#146;s Right of First Refusal.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>6.&nbsp;Use</B>. Subtenant agrees to use the Subleased Premises in accordance with the provisions of
the Master Lease and this Sublease, and for no other purpose.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>7.&nbsp;Master Lease</B>. As applied to this Sublease, the words &#147;Lessor&#148; and &#147;Lessee&#148; in the Master
Lease will be deemed to refer to Sublandlord and Subtenant, respectively, under this Sublease.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Except as otherwise expressly provided in Section&nbsp;9 of this Sublease, the covenants,
agreements, provisions, and conditions of the Master Lease, to the extent that they relate to the
Subleased Premises and to the extent that they are not inconsistent with the terms of this
Sublease, are made a part of and incorporated into this Sublease as if recited in full in this
Sublease.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Except as otherwise provided herein, the rights and obligations of the Master Landlord, as
&#147;Lessor,&#148; and the Subtenant, as &#147;Lessee,&#148; under the Master Lease will be deemed the rights and
obligations of Sublandlord and Subtenant, respectively, under this Sublease, and will inure to the
benefit of, and be binding on, Sublandlord and Subtenant, respectively. As between the parties to
this Sublease only, in the event of a conflict between the terms of the Master Lease and the terms
of this Sublease, the terms of this Sublease will control. For the avoidance of doubt, this means
that if Subtenant must obtain the Master Landlord&#146;s consent under the Master Lease for any matter,
then under this Sublease, the Subtenant must obtain the consent of both Sublandlord and Master
Landlord.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>8.&nbsp;Performance by Sublandlord; Status of Master Lease.</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>8.1 Sublandlord&#146;s Performance Conditioned on Master Landlord&#146;s Performance</B>. Subtenant
recognizes that Sublandlord is not in a position to render any of the services or to perform any of
the obligations required of Master Landlord by the terms of the Master Lease, except as otherwise
provided in this Sublease. Therefore, despite anything to the contrary in this Sublease, Subtenant
agrees that performance by Sublandlord of its obligations under this Sublease is conditioned on
performance by the Master Landlord of its corresponding obligations under the Master Lease, and
Sublandlord will not be liable to Subtenant for any default of the Master Landlord under the Master
Lease, except to the extent caused by
</DIV>


<P align="center" style="font-size: 10pt">7
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Sublandlord&#146;s default under the Master Lease which is not
caused by Subtenant&#146;s default hereunder.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Subtenant will not have any claim against Sublandlord based on the Master Landlord&#146;s failure
or refusal to comply with any of the provisions of the Master Lease unless that failure or refusal
is a result of Sublandlord&#146;s breach of the Master Lease. Despite the Master Landlord&#146;s failure or
refusal to comply with any of those provisions of the Master Lease, this Sublease will remain in
full force and effect and Subtenant will pay the base rent and additional rent and all other
charges provided for in this Sublease without any abatement, deduction or setoff. Except as
expressly provided in this Sublease, Subtenant agrees to be subject to, and bound by, all of the
covenants, agreements, terms, provisions, and conditions of the Master Lease, as though Subtenant
was Lessee under the Master Lease.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>8.2 Obtaining Master Landlord&#146;s Consent</B>. Whenever the consent of the Master Landlord is
required under the Master Lease, and whenever the Master Landlord fails to perform its obligations
under the Master Lease, Sublandlord agrees to use its good faith efforts to obtain, at Subtenant&#146;s
sole cost and expense, that consent or performance on behalf of Subtenant. Sublandlord covenants
and agrees with Subtenant that Sublandlord will pay all fixed rent and additional rent payable by
Sublandlord as Lessee pursuant to the Master Lease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>8.3 No Existing Defaults</B>. Sublandlord represents and warrants to Subtenant that the Master
Lease is in full force and effect, and Sublandlord has neither given nor received a notice of
default under the Master Lease, and to Sublandlord&#146;s knowledge, no event has occurred or condition
exists, which, with the passage of time or giving of notice, would constitute a default under the
Master Lease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>8.4 Preservation of Master Lease</B>. Sublandlord agrees not to terminate the Master Lease
voluntarily, or modify the Master Lease in a manner that increases Subtenant&#146;s obligations or
adversely affects Subtenant&#146;s rights under this Sublease without Subtenant&#146;s prior written consent;
<I>provided, however, </I>Sublandlord shall give prior written notice to Subtenant of any proposed
modifications to the Master Lease, and shall provide Subtenant with copies of any modifications to
the Master Lease promptly following execution by Sublandlord and Master Landlord. In the event of any
Sublandlord Termination Event (as defined below), Sublandlord shall be liable for, and Subtenant
shall be entitled to recover, Subtenant&#146;s actual damages incurred due to the termination of this
Sublease as a result of such Sublandlord Termination Event, including costs incurred in securing
alternative comparable space. &#147;<U>Sublandlord Termination Event</U>&#148; means a termination of the
Master Lease where Subtenant is not permitted or offered the opportunity to remain in the Subleased
Premises on the same terms as this Sublease, and which termination is the result of: (i)&nbsp;a default
of Sublandlord under the Master Lease, and such Sublandlord default was not as a result of a
Subtenant default under this Sublease; (ii)&nbsp;the result of any election or exercise of a right or
option held by Sublandlord under the Master Lease to effect such termination; or (iii)
Sublandlord&#146;s mutual agreement with the Master Landlord to terminate the Master Lease outside the
parameters of the Master Lease. Subtenant and Sublandlord will each refrain from any act or
omission that would result in the failure or breach of any of the covenants, provisions, or
conditions of the Master Lease on the part of Lessee under the Master Lease, provided that
Subtenant&#146;s compliance with its obligations under this Sublease shall satisfy the foregoing
requirement.
</DIV>


<P align="center" style="font-size: 10pt">8
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.&nbsp;Variations from Master Lease</B>. As between Sublandlord and Subtenant, the terms and
conditions of the Master Lease are modified as stated below in this Section&nbsp;9:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.1 Base Rent; Term; Security Deposit</B>. Despite anything to the contrary stated in the Master
Lease, the Term of this Sublease and Base Rent and the amount of the security deposit required of
the Subtenant are as stated in Sections&nbsp;2 and 3 above.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.2 Brokers</B>. The parties to this Sublease warrant to each other that neither party dealt with
any broker or finder in connection with the consummation of this Sublease other than Burnham Real
Estate and Irving Hughes (the &#147;<U>Brokers</U>&#148;), and each party agrees to protect, defend,
indemnify and hold the other party harmless from and against any and all claims or liabilities for
brokerage commissions or finder&#146;s fees arising out of that party&#146;s acts in connection with this
Sublease to anyone other than the Brokers. Sublandlord shall be solely responsible for payment of
all fees and commissions to the Brokers payable in connection with this Sublease. The provisions
of this Section&nbsp;9.2 will survive the expiration or earlier termination of this Sublease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.3 Maintenance of the Building</B>. Subject to Section&nbsp;14.7 and 14.8, Sublandlord, subject to
reimbursement pursuant to Section&nbsp;4, shall keep in good order, condition and repair the
foundations, exterior walls, interior bearing walls, exterior roof, fire sprinkler system, fire
hydrants, parking lots, walkways, parkways, driveways, landscaping, fences, signs and utility
systems that serve the common areas or that serve both the Second Floor Space and the Premises and
shall maintain and operate the HVAC System. Sublandlord shall not be obligated to paint the
exterior or interior surfaces of exterior walls nor shall Sublandlord be obligated to maintain,
repair or replace windows, doors or plate glass of the Premises. Subtenant expressly waives the benefit
of any statute now or hereafter in effect to the extent it is inconsistent with the terms of this
Sublease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.4 Notices</B>. Any notice that may or must be given by either party under this Sublease will be
delivered (i)&nbsp;personally, (ii)&nbsp;by certified mail, return receipt requested, or (iii)&nbsp;by a
nationally recognized overnight courier, addressed to the party to whom it is intended. Any notice
given to Sublandlord or Subtenant shall be sent to the respective address set forth on the
signature page below, or to such other address as that party may designate for service of notice by
a notice given in accordance with the provisions of this Section&nbsp;9.4. A notice sent pursuant to
the terms of this Section&nbsp;9.4 shall be deemed delivered (A)&nbsp;when delivery is attempted, if
delivered personally, (B)&nbsp;three (3)&nbsp;business days after deposit into the United States mail, or (C)
the business day following deposit with a nationally recognized overnight courier.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.5 Amounts Payable</B>. All amounts payable under this Sublease by Subtenant are payable
directly to Sublandlord.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.6 Provisions of Master Lease Not Applicable</B>. The following provisions of the Master Lease
shall not apply to this Sublease: (a)&nbsp;Sections&nbsp;1.1 through 1.7, inclusive, 1.10, 3, 10.1, 10.2,
15, 16.1 (provided that Subtenant shall execute any such statement if so requested by Master
Landlord), 22 (but only the last sentence thereof), 23, 49(b), 50, 51, 54, 62 and 63, (b)&nbsp;Exhibits
A, B, and C to the Master Lease, (c)&nbsp;the entire Second Amendment, and (d)&nbsp;all references in the
Master Lease to &#147;Tenant Improvements&#148; and &#147;Letter of Credit.&#148;
</DIV>


<P align="center" style="font-size: 10pt">9
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.7 &#147;As-Is.&#148; </B>Sublandlord will deliver the Subleased Premises to Subtenant in their current
&#147;as is&#148; condition; <I>provided, however, </I>that the Subleased Premises shall be in broom-clean
condition, and the Sublandlord shall deliver all plumbing, mechanical, electrical lighting and
other building systems in the Subleased Premises to the Subtenant in good working order.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Notwithstanding the foregoing, Sublandlord, at Sublandlord&#146;s sole cost, shall use commercially
reasonable efforts to, prior to the Commencement Date, (a)&nbsp;install additional key card security
readers in the Building for purposes of protecting the Subleased Premises against unauthorized
access by the occupant of the Building&#146;s second floor (the &#147;<U>Second Floor Occupant</U>&#148;), and to
protect the second floor of the Building against unauthorized access, as set forth in greater
detail in <U>Exhibit&nbsp;D-1</U>, and (b)&nbsp;construct a demising wall as set forth in greater detail in
<U>Exhibit&nbsp;D-2</U>. The Subtenant shall control, manage, operate and maintain the key card
security access system of the Building. At the direction of any Second Floor Occupant, the
Subtenant shall issue key cards to such individuals designated by any Second Floor Occupant and
shall manage the key card security access system so that only such designated individuals are
permitted access to the Second Floor Space and so that such designated individuals are not
permitted access to the Subleased Premises.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.8 Furniture, Fixtures and Equipment</B>. Sublandlord and Subtenant agree that the Subleased
Premises contain the furniture, fixtures and equipment listed on <U>Exhibit&nbsp;E</U> to this Sublease
(the &#147;<U>FF&#038;E</U>&#148;). The FF&#038;E shall not contain any furniture, fixtures or equipment currently
located in the Second Floor Space. Subject to the last sentence of this Section&nbsp;9.8, Subtenant
will not remove, and shall have no obligation to remove, any of the FF&#038;E on the expiration of the
Term of this Sublease. Subtenant shall have free use of all existing FF&#038;E during the Term,
excluding any readily moveable scientific equipment (the &#147;<U>Moveable Equipment</U>&#148;) which has
been sold prior to May&nbsp;1, 2006. Sublandlord shall not be permitted to remove any of the FF&#038;E other
than the Moveable Equipment from the Subleased Premises. Subtenant shall be entitled to an option
to purchase the FF&#038;E (other than any Moveable Equipment sold by Sublandlord prior to May&nbsp;1, 2006 as
permitted hereunder) for the sum of $1.00 immediately following the thirty-sixth (36<SUP style="font-size: 85%; vertical-align: text-top">th</SUP>)
month of this Sublease, which option may be exercised by written notice by Subtenant given to
Sublandlord at any time thereafter during the Term. Following Subtenant&#146;s exercise of its option
hereunder, the parties shall execute all agreements, instruments and undertakings reasonably
necessary to transfer Sublandlord&#146;s right, title and interest in, to and under such FF&#038;E to
Subtenant.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.9 Parking</B>. Subject to the terms of the Master Lease, Subtenant shall have exclusive use of
159 unreserved parking spaces (Subtenant&#146;s Pro Rata Share of the 210 available parking spaces) on
the Premises as designated by the Sublandlord from time to time. Subtenant shall not service or
store any vehicles on the Premises without the prior consent of Sublandlord.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.10 Common Areas</B>. The term &#147;Common Areas&#148; is defined as all areas and facilities outside the
Building and within the exterior boundary line of the Premises and interior utility raceways and
installations within the Building that are provided and designated by Sublandlord from time to time
for the general non-exclusive use of Sublandlord, Subtenant and other tenants of the Building and
their respective employees, suppliers, shippers, customers, contractors and invitees, including
stairwells, elevator, parking areas, loading and unloading
</DIV>


<P align="center" style="font-size: 10pt">10
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">areas, trash areas, roadways, driveways,
walkways, and landscaped areas. The Sublandlord grants the Subtenant, for the benefit of
Subtenant, its employees, suppliers, shippers, contractors, customer and invitees, during the Term
of this Sublease, the nonexclusive right to use, in common with others entitled to such use, the
Common Areas as they exist from time to time, subject to any rights, powers and privileges reserved
by Sublandlord or the Master Landlord under the terms of this Sublease or the Master Lease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.11 Reception</B>. Subtenant shall permit the Second Floor Occupant and its officers, employees,
contractors and invitees (collectively, &#147;<U>Second Floor Occupant Parties</U>&#148;) to have access to
the Second Floor Space twenty-four (24)&nbsp;hours per day, seven (7)&nbsp;days per week through the
Building&#146;s lobby and reception area portion of the Subleased Premises that is shown as shaded
on <U>Exhibit&nbsp;F</U> as attached hereto (the &#147;<U>Reception Area</U>&#148;), and Sublandlord reserves
such right herein; <I>provided, however, </I>the Second Floor Occupant Parties shall comply with all
reasonable security requirements and policies of Subtenant that do not unreasonably restrict access
to the Second Floor Space in connection with such access rights.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.12 Signage</B>. Subject to Section&nbsp;34 of the Master Lease, Subtenant shall be allowed external
monument signage as is approved by the Sublandlord and Master Landlord. The size of such external
signage and directional signage shall be consistent with Subtenant&#146;s Pro Rata Share. Subtenant
shall also be allowed exclusive internal signage in the Reception Area of the Building as is
approved by the Sublandlord and Master Landlord and the Second Floor Occupant&#146;s internal signage
rights shall be limited to the second floor of the Building; <I>provided, however, </I>the Second Floor
Occupant shall be permitted internal directional signage in the Reception Area consistent with its
pro rata share of rentable square footage in the Building, which signage shall be subject to
Subtenant&#146;s prior approval.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>9.13 Improvements</B>. Subject to Section&nbsp;7.3 of the Sublease, Subtenant shall not make any
improvements or alterations to the Subleased Premises without the prior written consent of
Sublandlord and Master Landlord; <I>provided</I>, <I>however</I>, no prior consent of Sublandlord shall be
required for any alterations which are non-structural in nature, do not adversely affect the
Building systems and do not exceed $25,000.00 in any year. Subtenant shall present to Sublandlord
in written form detailed plans for any proposed improvements or alterations. All consents given by
Sublandlord shall be deemed conditioned upon (i)&nbsp;the consent of the Master Landlord, (ii)
Subtenant&#146;s acquiring all applicable permits required by governmental authorities, (iii)&nbsp;the
furnishing of copies of such permits together with a copy of the plans and specifications for such
improvements or alterations to Sublandlord prior to the commencement of the work thereon, and (iv)
the compliance by Subtenant with all conditions of said permits. Sublandlord shall indicate in
writing whether any proposed alterations shall be required to be removed at the expiration of the
Term at the same time Sublandlord gives its consent to such alterations. In the event that
Subtenant requests Sublandlord&#146;s consent and Sublandlord fails to indicate whether such removal
shall be required at the time of its consent, Sublandlord shall be conclusively deemed to have
waived its right to require such removal. Any improvements or alterations done by Subtenant during
the Term of this Sublease shall be done in a good and workmanlike manner with good and sufficient
materials and in compliance with all applicable laws. The Subtenant shall promptly upon the
completion thereof furnish Sublandlord with as-built plans and specifications therefor.
Sublandlord may (but without obligation to do so) condition its consent to any requested
improvement or alteration that costs $100,000.00 or
</DIV>


<P align="center" style="font-size: 10pt">11
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">more upon Subtenant&#146;s providing Sublandlord
with a lien and completion bond in an amount equal to one and one-half times the estimated cost of
such improvement or alteration and/or upon Subtenant&#146;s posting an additional security deposit with
Sublandlord under Section&nbsp;3 hereof.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>10.&nbsp;Indemnity</B>. Subtenant agrees to protect, defend, indemnify, and hold Sublandlord harmless from and
against any and all liabilities, claims, expenses, losses and damages (including reasonable
attorney fees and costs), that may at any time be asserted against Sublandlord by (a)&nbsp;the Master
Landlord for failure of Subtenant to perform any of the covenants, agreements, terms, provisions,
or conditions contained in the Master Lease that Subtenant is obligated to perform under the
provisions of this Sublease; or (b)&nbsp;any person as a result of Subtenant&#146;s use or occupancy of the
Subleased Premises, except to the extent any of the foregoing is caused by the gross negligence or
willful misconduct of Sublandlord. The provisions of this Section&nbsp;10 will survive the expiration
or earlier termination of this Sublease.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>11.&nbsp;Cancellation of Master Lease</B>. In the event the Master Lease is canceled or terminated for
any reason, or involuntarily surrendered by operation of law before the expiration date of this
Sublease, Subtenant agrees, at the sole option of the Master Landlord, to attorn to the Master
Landlord for the balance of the Term of this Sublease and on the then executory terms of this
Sublease. That attornment will be evidenced by a non-disturbance agreement in form and substance
reasonably satisfactory to the Master Landlord and Subtenant. Subtenant agrees to execute and
deliver such an agreement at any time within ten (10)&nbsp;business days after request by the Master
Landlord. Subtenant waives the provisions of any law now or later in effect that may provide
Subtenant any right to terminate this Sublease or to surrender possession of the Subleased Premises
in the event any proceeding is brought by the Master Landlord to terminate the Master Lease.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>12.&nbsp;Certificates</B>. Each party to this Sublease will, from time to time as requested by the
other party, on not less than twenty (20)&nbsp;days prior written notice, execute, acknowledge, and
deliver to the other party a statement in writing certifying that this Sublease is unmodified and
in full force and effect (or if there have been modifications that this Sublease is in full force
and effect as modified and stating the modifications). That statement will certify the dates to
which base rent, additional rent, and any other charges have been paid. That statement will also
state whether, to the knowledge of the person signing the certificate, the other party is in
default beyond any applicable grace period provided in this Sublease in the performance of any of
its obligations under this Sublease. If the other party is in default beyond any applicable grace
period, the statement will specify each default of which the signer then has knowledge. It is
intended that this statement may be relied on by others with whom the party requesting that
certificate may be dealing.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>13.&nbsp;Assignment or Subleasing</B>. Subject to the rights of the Master Landlord and the
restrictions contained in Section&nbsp;12 of the Master Lease, Subtenant may not assign this Sublease or
sublet all or any portion of the Subleased Premises without the prior written consent of
Sublandlord, which consent may not be unreasonably withheld, conditioned or delayed; <I>provided,
however</I>, Sublandlord&#146;s consent shall not be required for any Permitted Transfer.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.&nbsp;General Provisions.</B>
</DIV>

<P align="center" style="font-size: 10pt">12
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.1 Severability</B>. If any provision of this Sublease or the application of any provision of
this Sublease to any person or circumstance is, to any extent, held to be invalid or unenforceable,
the remainder of this Sublease or the application of that provision to persons or circumstances
other than those as to which it is held invalid or unenforceable, will not be affected, and each
provision of this Sublease will be valid and be enforced to the fullest extent permitted by law.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.2 Entire Agreement; Waiver</B>. This Sublease constitutes the final, complete and exclusive
statement between the parties to this Sublease pertaining to the Subleased Premises, supersedes all
prior and contemporaneous understandings or agreements of the parties, and is binding on and inures
to the benefit of their respective heirs, representatives, successors, and assigns. No party has
been induced to enter into this Sublease by, nor is any party relying on, any representation or
warranty outside those expressly set forth in this Sublease. Any agreement made after the date of
this Sublease is ineffective to modify, waive, release, terminate, or effect an abandonment of this
Sublease, in whole or in part, unless that agreement is in writing, is signed by the parties to
this Sublease, and specifically states that that agreement modifies this Sublease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.3 Captions</B>. Captions to the Sections in this Sublease are included for convenience only
and do not modify any of the terms of this Sublease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.4 Further Assurances</B>. Each party to this Sublease will at its own cost and expense execute
and deliver such further documents and instruments and will take such other actions as may be
reasonably required or appropriate to evidence or carry out the intent and purposes of this
Sublease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.5 Governing Law</B>. This Sublease will be governed by and in all respects construed in
accordance with the laws of the State of California.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.6 Consent of Landlord</B>. The Master Landlord&#146;s written consent to this Sublease in
accordance with the terms of Article&nbsp;12 of the Master Lease is a condition subsequent to the
validity of this Sublease. If the Master Landlord&#146;s consent has not been obtained and a copy of
that consent delivered to Subtenant by the thirtieth (30th) day following the date of this
Sublease, each party shall thereafter have the ongoing right, subject to the terms of this Section
14.6, to terminate this Sublease pursuant to a notice (the &#147;<U>Termination Notice</U>&#148;) so stating
delivered to Sublandlord. If Sublandlord fails to deliver to Subtenant the consent of Master
Landlord to this Sublease within ten (10)&nbsp;days following receipt of the Termination Notice (the
&#147;<U>Termination Date</U>&#148;), this Sublease shall automatically terminate and the parties shall be
released from any further obligations under this Sublease. If, however, Sublandlord delivers to
Subtenant the consent of Master Landlord on or before the Termination Date, the condition subsequent set forth in this
Section&nbsp;14.6 shall be satisfied and this Sublease shall continue in full force and effect. <U>
</U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.7 Condemnation</B>. In the event that all of the Subleased Premises are taken, this
Sublease shall terminate in accordance with the terms of the Master Lease. If less than all of the
entire Subleased Premises are taken, the provisions of the Master Lease shall control with respect
to whether this Sublease will be terminated as a result thereof, and with respect to
</DIV>


<P align="center" style="font-size: 10pt">13
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">restoration of the Subleased Premises. Subtenant shall have no right to share in any condemnation proceeds
received by Sublandlord; <I>provided, however, </I>Subtenant shall have the right to pursue any separate
award for loss of its equipment, trade fixtures and moving expenses. In no event will Sublandlord
be in default under this Sublease or be liable to Subtenant or any other person for direct,
indirect, or consequential damages, or otherwise (except to the extent caused by Sublandlord&#146;s
gross negligence or willful misconduct), for any termination of the Master Lease pursuant to such
provisions, or for any failure of Master Landlord to repair or restore the Subleased Premises or to
otherwise perform any of its obligations under such condemnation provisions in the Master Lease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.8 Casualty</B>. In the event that the Subleased Premises shall be damaged by fire or other
casualty, Sublandlord shall have no responsibility for restoration of the Subleased Premises. The
casualty provisions of the Master Lease shall control with respect to termination of this Sublease
and restoration of the Subleased Premises. In no event will Sublandlord be in default under this
Sublease or be liable to Subtenant or any other person for direct, indirect or consequential
damages, or otherwise (except to the extent caused by Sublandlord&#146;s gross negligence or willful
misconduct), for any termination of the Master Lease pursuant to such provisions, or for any
failure of Master Landlord to repair or restore the Subleased Premises or to otherwise perform any
of its obligations under such casualty provisions in the Master Lease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.9 Capitalized Terms</B>. All terms spelled with initial capital letters in this Sublease that
are not expressly defined in this Sublease will have the respective meanings given such terms in
the Master Lease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.10 Word Usage</B>. Unless the context clearly requires otherwise, (a)&nbsp;the plural and singular
numbers will each be deemed to include the other; (b)&nbsp;the masculine, feminine, and neuter genders
will each be deemed to include the others; (c) &#147;shall,&#148; &#147;will,&#148; &#147;must,&#148; &#147;agrees,&#148; and &#147;covenants&#148;
are each mandatory; (d) &#147;may&#148; is permissive; (e) &#147;or&#148; is not exclusive; and (f) &#147;includes&#148; and
&#147;including&#148; are not limiting.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.11 &#147;Including&#148;</B>. The term &#147;including&#148; as used herein shall be interpreted to mean including without limitation.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.12 Incorporation of Exhibits</B>. The various exhibits to this Sublease are hereby
incorporated by reference into this Sublease.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>14.13 Venue; Counterparts</B>. In any action brought or arising out of this Sublease, the parties
hereto hereby consent to the jurisdiction of any federal or state court having proper venue within
the State of California and also consent to the service of process by any means authorized by
California or federal law. The parties hereby agree that any proceeding relating to any dispute
under this Sublease or with respect to the interpretation of any provision of this Sublease shall
be conducted in San Diego, California. This Sublease may be executed in one or more counterparts,
all of which, taken together, shall constitute one and the same Sublease.
</DIV>


<P align="center" style="font-size: 10pt">14
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The parties have executed this Sublease as of the date specified above.
</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="40%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="37%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="17%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="5" valign="top" align="left">SUBLANDLORD:</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="5" valign="top" align="left"><B>CANCERVAX CORPORATION</B>,</TD>
</TR>
<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="5" valign="top" align="left">a Delaware corporation</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">/s/ David&nbsp;F. Hale</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR style="font-size: 1px">

    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Name:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">David&nbsp;F. Hale</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>


<TR style="font-size: 1px">

    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>



<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Title:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">President and CEO
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="5" valign="top" align="left">SUBTENANT:</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="5" valign="top" align="left"><B>GENOPTIX, INC</B>.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="5" valign="top" align="left">a Delaware corporation</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">/s/ Tina&nbsp;S. Nova, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR style="font-size: 1px">

    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>


<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Name:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Tina&nbsp;S. Nova, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR style="font-size: 1px">

    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Title:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">President and CEO</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>EXHIBIT A</B></U>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>MASTER LEASE</B>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 6pt">&#091;Attached&#093;
</DIV>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>EXHIBIT B</B></U>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>DESCRIPTION OF SUBLEASED PREMISES</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The ground floor (consisting of 46,527 square feet) of the office building located at 2110
Rutherford Road, Carlsbad, California.
</DIV>

<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>EXHIBIT C</B></U>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>BASE RENT SCHEDULE</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Beginning on August&nbsp;1, 2006, the Base Rent to be paid by the Subtenant to Sublandlord shall be
as follows:
</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="35%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="62%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">May&nbsp;1, 2006 through July&nbsp;31, 2006
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">-
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">No Base Rent</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">August&nbsp;1, 2006 through June&nbsp;30, 2007
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">-
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">$81,422.25 ($1.75 per rentable square foot) per month</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">July&nbsp;1, 2007 through June&nbsp;30, 2008
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">-
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">$83,864.92 ($1.80 per rentable square foot) per month</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">July&nbsp;1, 2008 through June&nbsp;30, 2009
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">-
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">$86,380.87 ($1.86 per rentable square foot) per month</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">July&nbsp;1, 2009 through June&nbsp;30, 2010
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">-
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">$88, 972.29 ($1.91 per rentable square foot ) per month</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">July&nbsp;1, 2010 through June&nbsp;30, 2011
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">-
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">$91,641.46 ($1.97 per rentable square foot) per month</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">July&nbsp;1, 2011 through June&nbsp;30, 2012
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">-
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">$94,390.70 ($2.03 per rentable square foot) per month</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Subtenant agrees to pay to Sublandlord the Base Rent according to the terms and conditions set
forth in Section&nbsp;3 of this Sublease.
</DIV>

<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>EXHIBIT D-1</B></U>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>CARD ACCESS PLAN</B>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>EXHIBIT D-2</B></U>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>DEMISING WALL IMPROVEMENTS</B>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>EXHIBIT E</B></U>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>LIST OF FF&#038;E</B>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>EXHIBIT F</B></U>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>SECOND FLOOR OCCUPANT ACCESS AREAS</B>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>


</BODY>
</HTML>
</TEXT>
</DOCUMENT>
