MILLENNIUM PHARMACEUTICALS INC
EXHIBIT 10.1
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<p align=right>
<font face="Times New Roman, Times, Serif" size=2><b>Exhibit No. 10.1</b></font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2><b>Confidential Materials omitted and filed separately with the Securities and Exchange<br>Commission.&nbsp;&nbsp; Asterisks denote omissions.</b></font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2><b>AMENDMENT NO. 6</b></font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2><b>to</b></font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2><b>AGREEMENT</b></font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2><b>by and between</b></font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2><b>BAYER AG AND MILLENNIUM PHARMACEUTICALS, INC.</b></font></p>

<p align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This is Amendment No. 6 ("Amendment No. 6") dated as of March 22, 2002 (the "Amendment Effective Date"), to the Agreement,
dated as of September 22, 1998 (as amended, the "Agreement"), by and between Bayer AG, located at D 51368 Leverkusen, Germany and
Millennium Pharmaceuticals, Inc., located at 75 Sidney Street, Cambridge, Massachusetts 02139. The Agreement has previously been
amended by Amendment No. 2 dated as of December 1, 1999, Amendment No. 3 dated as of September 18, 2000, Amendment No. 4 dated as of
December 1, 2000 and Amendment No. 5 dated as of September 7, 2001. The Parties acknowledge that there is no Amendment No. 1 to this
Agreement.</font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2><u>INTRODUCTION</u></font></p>


<p align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Parties have determined that it is in their mutual best interests to amend the Agreement in the manner set forth below.</font></p>

<p align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>Use of Terms</u>. Capitalized terms used herein and not defined herein shall have the respective meanings ascribed to such
terms in the Agreement.</font></p>

<p align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>Article I - Definitions</u>.</font></p>


<p align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>Section 1.8</u>.&nbsp;&nbsp;&nbsp;&nbsp;Section 1.8 of the Agreement is hereby amended by deleting Section<br>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.8 in its entirety and by substituting the
following in its place:</font></p>

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"Section 1.8 "<u>Bayer Returned QT Know-How</u>" means Know-How owned or otherwise controlled by Bayer (as of the date
Millennium exercises the option under Section 3.2(d) with respect to the applicable Bayer Returned QT Know-How), in
which Bayer has a licensable or sublicensable interest and which Bayer has developed or acquired as a result of the
Discovery Program and/or the Bayer Development Program, relating to (a) a Returned QT, the use of a Returned QT to
discover and develop Small Molecule Drugs, the treatment of diseases and/or conditions with Small Molecule Drugs
that interact with a Returned QT, and the Bayer Configured Assay relating to a Returned QT, and/or (b) the lead
structure under development by Bayer and related data (as more specifically set forth in Section 3.2(d))."</font></td>
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<p align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.&nbsp;&nbsp;&nbsp;&nbsp;<u>Provisions Relating to Specific QTs</u>.&nbsp;&nbsp;&nbsp;&nbsp;Notwithstanding Section 3.2(d)(ii), the parties agree that Millennium has validly
exercised its option under Section 3.2(d)(i) with respect to the following Returned QTs: [**]. Attached hereto as <u>Exhibit A</u> are
signed letters memorializing Millennium's exercise of its option under Section 3.2(d)(i) with respect to each of the above-noted
Returned QTs. The effective date for the licenses granted as a result of Millennium's exercise of each of these options shall be
March 22, 2002.</font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2>[Remainder of page intentionally left blank.]</font></p>
<p align=center><font face="Times New Roman, Times, Serif" size=2>2</font></p>
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<p align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.&nbsp;&nbsp;&nbsp;&nbsp;<u>General</u>. In all other respects, the Agreement is hereby ratified and confirmed.</font></p>
<p align=left><font face="Times New Roman, Times, Serif" size=2>IN WITNESS WHEREOF, the Parties have executed this Amendment No. 6 as of the date set forth above.
</font></p>

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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td colspan=2><font face="Times New Roman, Times, Serif" size=2>BAYER AG<br><br></font></td>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>By:&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2><u>/s/&nbsp;&nbsp;Dr. Wolfgang Ehrenstein</u></font></td>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>Title:&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2><u>/s/&nbsp;&nbsp;Head of PL Department Health Care</u></font></td>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
</tr>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>By:&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2><u>/s/&nbsp;&nbsp;Dr. Wolfgang Hartwig</u></font></td>
</tr>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>Title:&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2><u>&nbsp;&nbsp;Executive VP for Research</u></font></td>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
</tr>
<tr valign=bottom>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td colspan=2><font face="Times New Roman, Times, Serif" size=2>MILLENNIUM PHARMACEUTICALS, INC.<br><br></font></td>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>By:&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2><u>/s/&nbsp;&nbsp;Alan Crane</u></font></td>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>Title:&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2><u>SVP Corporate Development</u></font></td>
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<p align=center><font face="Times New Roman, Times, Serif" size=2>3</font></p>
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<p align=center><font face="Times New Roman, Times, Serif" size=2><b><u>Exhibit A</u><br>

<u>Exercise Letters for</u><br>

<u>Bayer Returned QT Know-How</u><br>

<u>And Bayer Returned QT Patent Rights</u></b></font></p>



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<p align=center><font face="Times New Roman, Times, Serif" size=2><b><i>[Form of Exercise Letters for Bayer Returned QT Know-How<br>
and Bayer Returned QT Patent Rights]</i></b></font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2>[Millennium Letterhead]</font></p>




<p align=center><font face="Times New Roman, Times, Serif" size=2>&nbsp;&nbsp;&nbsp;&nbsp;[March ___, 2002]</font></p>


<p align=left><font face="Times New Roman, Times, Serif" size=2>Bayer AG<br>
PH-R L, Bldg. 0402<br>
Elberfeld, Wuppertal<br>
D-42096, Germany</font></p>

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<td width=5% align=left><font face="Times New Roman, Times, Serif" size=2>Re:<br>&nbsp;</font></td>
<td width=65%><font face="Times New Roman, Times, Serif" size=2>Option under Section 3.2(d) of Agreement by and between Bayer AG and<br><u>Millennium Pharmaceuticals, Inc. dated September 22, 1998, as amended.</u></font></td>
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<p align=left><font face="Times New Roman, Times, Serif" size=2>Dear <u>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u>:</font></p>

<p align=left><font face="Times New Roman, Times, Serif" size=2>Reference is made to the Agreement by and between Bayer AG ("Bayer") and Millennium Pharmaceuticals, Inc. ("MPI") dated September 22,
1998, as amended (the "Agreement").</font></p>


<p align=left><font face="Times New Roman, Times, Serif" size=2>In accordance with Section 3.2(d)(ii) of the Agreement, Millennium hereby notifies Bayer of its exercise of the option set forth in
Section 3.2(d)(i) with respect to Returned QT __. The specific Bayer Returned QT Know-How and Bayer Returned QT Patent Rights
requested with respect to this Returned QT are ____________________________________________________________.</font></p>



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<td width=65% align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=20%><font face="Times New Roman, Times, Serif" size=2>Very truly yours,<br>&nbsp;<br>Ron Farquhar, Ph.D.<br>Senior Program Director</font></td>
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