TARGETED GENETICS CORP /WA/
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<TYPE>EX-10.02
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<H1 ALIGN=right><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Exhibit 10.02 </FONT></H1>
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<FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>FIFTH AMENDMENT TO LEASE AGREEMENT</B> </FONT></P>
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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This
FIFTH AMENDMENT TO LEASE AGREEMENT (This &#147;Amendment&#148;) is entered into as of June
20, 2003 by and between Ironwood Apartments, Inc., as successor to Metropolitan Federal
Savings and Loan Association (&#147;Landlord&#148;) and Targeted Genetics Corporation
(&#147;Tenant&#148;). </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Landlord
and Tenant are parties to that certain Olive Way Building Lease dated November 20, 1992,
as modified by that certain First Amendment to Olive Way Building Lease dated December 10,
1994 and that certain Second Amendment to Lease Agreement executed on June 12, 1996 and
May 22 1996, and that certain Third Amendment to Lease Agreement dated October 30, 1998,
and that certain Fourth Amendment to Lease Agreement dated February 5, 2001 (as modified,
the &#147;Lease&#148;). </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section
4.02 of the Lease grants to Tenant three (3) options to extend the Lease term for 5 years
each. Tenant exercised the first of these 3 options in that certain Third Amendment dated
October 30, 1998, leaving two options remaining. The purpose of this Amendment is to
exercise the second of these three options, leaving one remaining. </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Landlord
and Tenant do hereby amend the Lease as follows: </FONT></P>

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          <TD ALIGN=LEFT WIDTH=3%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><B>1.</B> </FONT></TD>
          <TD WIDTH=97%><P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
          <B>EXTENSION</B>. The term of the Lease is hereby extended for an additional 60
          months to <B>April 1, 2009</B>. The rent for the extended term is set forth in
          Section 6.02 of the Lease. </FONT></P></TD>
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          <TD ALIGN=LEFT WIDTH=3%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><B>2.</B> </FONT></TD>
          <TD WIDTH=97%><P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
          <B>NO OTHER AMENDMENTS. </B>Except as modified by this Amendment and by the
          Amendments referenced above, the Lease remains in full force and effect and has
          not been modified or amended. </FONT></P></TD>
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<P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2><I>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;DATED:
June 30, 2003.</I> </FONT></P>
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<TD WIDTH=50%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
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<FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>LANDLORD:</B><BR>
<BR>


IRONWOOD APARTMENTS, INC.,<BR>
a Washington corporation<BR>
<BR>
<BR>




Signature:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>/s/ John Stone</U><BR>
By:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>John Stone</U><BR>
Its:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>President
</U><BR>
<BR>


<B>TENANT:</B><BR>
<BR>


TARGETED GENETICS CORPORATION,<BR>
a Washington corporation<BR>
<BR>
<BR>


Signature:&nbsp;&nbsp;&nbsp;<U>/s/ Todd E. Simpson</U><BR>
By:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Todd E. Simpson</U><BR>
Its:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Vice President, Finance</U> </FONT>
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