ZYMOGENETICS INC
COLLABORATIVE AGREEMENT FOR IL-21
<DOCUMENT>
<TYPE>EX-10.29
<SEQUENCE>5
<FILENAME>dex1029.txt
<DESCRIPTION>COLLABORATIVE AGREEMENT FOR IL-21
<TEXT>
<PAGE>

                                                                   EXHIBIT 10.29

Confidential Treatment has been requested for portions of this exhibit. The copy
filed herewith omits the information subject to the confidentiality request.
Omissions are designed as ****. A complete version of this exhibit has been
filed separately with the Securities and Exchange Commission.

                       Collaborative Agreement for IL-21

This Collaborative Agreement ("Agreement") is effective as of December 14, 2002
(the "Effective Date"), and is entered into by and between ZymoGenetics, Inc., a
Washington corporation having a principal place of business at 1201 Eastlake
Avenue East, Seattle, Washington 98102 ("ZGI") and Novo Nordisk A/S, a Danish
corporation having a principal place of business at Novo Alle, DK-2880,
Bagsvaerd, Denmark ("NN").

         WHEREAS, ZGI and NN are parties to a certain License Agreement for
IL-21 effective as of August 21, 2001;

         WHEREAS, ZGI has generated data, intellectual property, and other
information subsequent to August 21, 2001 that relates to the research and
development of IL-21 Protein;

         WHEREAS, NN is interested in obtaining access and rights pertaining to
ZGI's data, intellectual property, and other information generated subsequent to
August 21, 2001 that relates to the research and development of IL-21 Protein,
pursuant to the terms of this Agreement;

         WHEREAS, ZGI is willing to grant NN access and rights to ZGI's data,
intellectual property, and other information generated subsequent to August 21,
2001 that relates to the research and development of IL-21 Protein, pursuant to
the terms of this Agreement;

         WHEREAS, the parties are interested in sharing costs and collaborating
on research and development necessary to move the IL-21 Protein toward IND;

NOW THEREFORE, IT IS HEREBY AGREED AS FOLLOWS:




<PAGE>

                                   ARTICLE 1
                                  Definitions

SECTION 1.1. Other Definitions.  Unless otherwise defined herein, any word used
herein as a defined word is capitalized and shall have the meaning set forth in
the License Agreement for IL-21.

SECTION 1.2. Guide to Definitions set forth in the License Agreement for IL-21.
For the convenience of the parties and as a guide, some of the words defined in
the License Agreement for IL-21 used herein are as follows:

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Word:                                    Section of License Agreement for IL-21:
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"IL-21 Embodiment"                       SECTION 1.6
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"IL-21 Protein"                          SECTION 1.8
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"IND"                                    SECTION 1.12
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"Net Sales"                              SECTION 1.14
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"North America" or "NA"                  SECTION 1.15
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"Rest of World" or "RoW"                 SECTION 1.22
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"Valid Claim"                            SECTION 1.24
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SECTION 1.3. Additional Definitions. Additional words defined in this Agreement
are defined in SECTIONS 1.4 through 1.12 below that are intended for
clarification of the subject matter of this Agreement only and in no way
constitute amendments to the License Agreement for IL-21.

SECTION 1.4. "Affiliate" means: any company, joint venture partnership, or other
business entity which controls, is controlled by, or is under common control of
the designated party; provided, however, that NN shall not be deemed to control
ZGI and neither NN nor ZGI shall be deemed to be an Affiliate of the other or
any subsidiary or other business entity that the other party controls. A
business entity shall be deemed to control another business entity if it
possesses, directly or indirectly, the power to order or cause the direction,
management and policies of such other business entity, whether through the
ownership of voting securities, by contract or otherwise.

SECTION 1.5. "IL-21 Program" means: all research, preclinical, process
development and manufacturing activities that are necessary or desirable for
ZGI's filing of an IND with the US FDA for the IL-21 Protein and that take place
between January 1, 2003 and ZGI's filing of such IND (or such earlier date that
the IL-21 Program is terminated pursuant to SECTION 3.1(c), 8.2, 8.3, 8.4, 8.5
or 8.6). The key activities for the IL-21 Program established by ZGI are
summarized in Exhibit A. Promptly after execution and delivery of this
Agreement, the Joint Project Team will create a detailed joint work plan,
approved by the Joint Steering Committee, containing activities with agreed
deliverables, budget, and time lines up to the filing of such IND, that may be
amended from time to time by mutual agreement in writing between the parties.

<PAGE>

SECTION 1.6. "IL-21 Program Inventions" means: any invention or discovery,
whether or not patentable, conceived or reduced to practice by either party or
its Affiliates, alone or jointly with others including NN or ZGI, in the course
of and during the IL-21 Program that relate to, and arise from work related to,
the IL-21 Protein, or the product based on the IL-21 Protein.

SECTION 1.7. "IL-21 Program Know-How" means: all inventions, discoveries,
know-how, methodologies, technology, tangible materials (including nucleic
acids, peptides, vectors, proteins and the like) that a party or its Affiliates
created or generated in the course of and during the IL-21 Program that relate
to, and arise from work related to, the IL-21 Protein, or the product based on
the IL-21 Protein.

SECTION 1.8. "IL-21 Program Patent Rights" means: all patents (including,
without limitations, all substitutions, extensions, registrations,
confirmations, reissues, reexaminations, renewals, supplementary protection
certificates and the like) and patent applications (including, without
limitations, any continuations, continuations in part or divisions and any
provisional applications) that (a) claim an IL-21 Program Invention, (b) have a
date of conception of the invention on or after January 1, 2003 and prior to
completion of the IL-21 Program and (c) are owned or controlled by a party or
its Affiliates.

SECTION 1.9. "Joint IL-21 Program Patent Rights" means: all IL-21 Program Patent
Rights arising or resulting from inventive work by one or more employees from
both parties (or their Affiliates), as to which the employees would be inventors
under the patent laws of the United States. Pursuant to SECTION 4.1, the parties
have equal, undivided ownership interests in Joint IL-21 Program Patent Rights.

SECTION 1.10. "License Agreement for IL-21" means the License Agreement for
IL-21 effective as of August 21, 2001, in which ZGI and NN are parties.

SECTION 1.11. "Respective Territory" means:  RoW with respect to NN and NA with
respect to ZGI.

SECTION 1.12. "Updated IL-21 Related IP" means:  all Updated IL-21 Related
Patents and all Updated IL-21 Related Know-How.

SECTION 1.13. "Updated IL-21 Related Know-How" means: all inventions,
discoveries, know-how, methodologies, technology, tangible materials (including
nucleic acids, peptides, vectors, proteins, and the like) that: (a) pertain to
at least one IL-21 Embodiment; (b) were invented, discovered, developed or
otherwise generated by or for ZGI; and (c) are owned and controlled by ZGI as of
January 1, 2003. For the avoidance of doubt, Updated IL-21 Related Know-How
shall not include: (i) know-how which at the time of disclosure is in the public
domain; (ii) know-how which, prior to the disclosure from ZGI to NN, was in NN's
possession; and (iii) know-how developed independently by NN without any use of
any confidential ZGI know-how or confidential ZGI patent rights whatsoever.

SECTION 1.14. "Updated IL-21 Related Patents" means: (a) the patents and patent
applications set forth in Appendix 2 of the License Agreement for IL-21 and
patents and patent applications

<PAGE>

in RoW with a date of conception of the invention prior to January 1, 2003 owned
or controlled by ZGI that claim at least one IL-21 Embodiment, or claim a method
of making, manufacture or using at least one IL-21 Embodiment, or claim a
process or formulation including mixtures comprising at least one IL-21
Embodiment; (b) all divisional or continuation (in whole or in part)
applications of the applications described in (a); (c) all patents issuing from
the applications described in (a) and (b); and (d) all extensions, supplemental
protection certificates (including any form of patent term extensions),
reissues, reexaminations, substitutions or renewals of the patents described in
(c).

SECTION 1.15. "Updated IL-21 Know-How Product" means: a product in final dosage
form that is not an Updated IL-21 Patent Product but that was developed through
use of any Updated IL-21 Related Patent or Updated IL-21 Related Know-How, or
which otherwise incorporates or embodies Updated IL-21 Related Know-How.
Notwithstanding the foregoing, an "SM Embodiment", which is further defined as
any small molecule that is a chemical entity that does not have a polypeptide
backbone, where an Updated IL-21 Related Patent or Updated IL-21 Related
Know-How, including the IL-21 Protein, was used as a tool in the discovery,
research or development of such chemical entity, shall be an Updated IL-21
Know-How Product in accordance with this Agreement, regardless of whether or not
it would otherwise be an Updated IL-21 Patent Product in accordance with SECTION
1.16 of this Agreement.

SECTION 1.16. "Updated IL-21 Patent Product" means: a product in final dosage
form the making, using, importation, exportation, offer for sale, or sale of
which would infringe, in the absence of the license granted under this
Agreement, any unexpired Valid Claim of an Updated IL-21 Related Patent.

SECTION 1.17. "Updated IL-21 Product" means: either an Updated IL-21 Know-How
Product or an Updated IL-21 Patent Product.

SECTION 1.18. "US FDA" means: the United States Food and Drug Administration.


                                    ARTICLE 2
  License and Reimbursement for ZGI Costs incurred since August 21, 2001, the
    Effective Date of the License Agreement for IL-21, until January 1, 2003

SECTION 2.1.  NN's Reimbursement of ZGI's costs. In accordance with the terms of
this Agreement, NN shall reimburse **** of ZGI's total costs incurred from the
Effective Date of the License Agreement for IL-21 until January 1, 2003, in the
undertaking of the research program for the IL-21 Protein. These total costs are
currently estimated by ZGI to be US$****. One half of the percentage amount
reimbursed by NN is contingent on ZGI satisfying four demonstration obligations
as set forth in SECTION 2.3.

**** designates portions of this document that have been omitted pursuant to a
request for confidential treatment filed separately with the commission.

<PAGE>

SECTION 2.2. Method of Payment. At the discretion of NN, NN shall reimburse ****
of ZGI's estimated total costs as described under SECTION 2.1 either in full
within three (3) business days after execution and delivery of this Agreement,
or in two installments as follows: a first installment of at least one-half of
the total estimated amount within three (3) business days after execution and
delivery of this Agreement; and a second installment of the remaining amount
within thirty (30) days after receipt of ZGI's documentation showing ZGI has
satisfied the demonstration obligations in SECTION 2.3. One half of the total
amount to be reimbursed by NN is contingent on ZGI satisfying four demonstration
obligations as set forth in SECTION 2.3; NN shall complete a due diligence
review of ZGI's documentation within thirty (30) days after receipt of ZGI's
documentation provided in satisfaction of the four demonstration obligations as
set forth in SECTION 2.3. If the four demonstration obligations in SECTION 2.3
are not satisfied by ZGI, the following shall occur: (a) within thirty (30) days
after NN's receipt of ZGI's documentation, NN must notify ZGI that ZGI has not
satisfied the demonstration obligations; (b) in the event NN pays in full upon
signing of this Agreement or the first installment is greater than one-half of
the total payment, then ZGI will be required to refund to NN the amount of the
payment received that is greater than one-half of the total payment within ten
(10) days after receipt of written notification by NN that ZGI has not satisfied
the demonstration obligations. By January 17, 2003, ZGI shall provide NN a
statement of its actual costs for the time period covered by SECTION 2.1 and any
adjusting payments shall be made between the parties by January 31, 2003 based
on the amounts previously paid by NN or to be paid by NN pursuant to SECTIONS
2.1 and 2.2. Notwithstanding the foregoing, NN shall not be required to pay ZGI
an amount in excess of **** of the estimated total costs of US$**** .

SECTION 2.3. Demonstration obligations. In accordance with the terms of this
Agreement, ZGI shall provide NN with documentation for the following four items:

a.       ****.

b.       ****

c.       ****

d.       ****

SECTION 2.4.  Meeting to Exchange Information.  Promptly after execution and
delivery of this Agreement, a mutually agreed upon meeting will be held to
exchange documentation, data and information between the parties that are
required to advance the IL-21 project toward IND. ZGI

**** designates portions of this document that have been omitted pursuant to a
request for confidential treatment filed separately with the commission.

<PAGE>

shall disclose data and critical information generated or obtained by ZGI from
Effective Date of the License Agreement for IL-21 through the date four (4)
weeks prior to such meeting. ZGI will provide documentation including full
disclosure of all information within forty-five (45) days after the date of the
meeting. If this meeting is not held within thirty (30) days after the execution
and delivery of this Agreement, ZGI shall then, in any event, promptly transfer
all information and documentation described in this SECTION 2.4 to NN.

SECTION 2.5. Amendments to License Agreement for IL-21. Only upon payment to ZGI
of the full amount due from NN pursuant to SECTIONS 2.1 and 2.2 (including the
one-half amount that is due upon, or becomes nonrefundable upon, satisfaction of
the demonstration obligations set forth in SECTION 2.3), the parties shall
promptly prepare and execute an amendment to incorporate Updated IL-21 Related
Know-How and Updated IL-21 Related Patents into the License Agreement for IL-21.
Amendments to the License Agreement for IL-21 shall include:

(a) amending the definition of IL-21 Related Know-How (SECTION 1.10(c) therein),
to incorporate all inventions, discoveries, know-how, methodologies, technology,
tangible materials (including nucleic acids, peptides, vectors, proteins, and
the like) that: (a) pertain to at least one IL-21 Embodiment; (b) were invented,
discovered, developed or otherwise generated by or for ZGI; and (c) are owned
and controlled by ZGI as of January 1, 2003;

(b) amending the definition of IL-21 Related Patents (SECTION 1.11(a) therein,
and including a new Appendix 3 to supplement the patents and patent applications
listed in Appendix 2 "IL-21 Related Patents"), to incorporate patent and patent
applications with a date of conception of the invention prior to January 1, 2003
owned or controlled by ZGI that claim at least one IL-21 Embodiment, or claim a
method of making, manufacture or using at least one IL-21 Embodiment, or claim a
process or formulation including mixtures comprising at least one IL-21
Embodiment;

(c) amending the article related to Royalties (SECTION 5.1 therein) to
incorporate that royalties payable by NN shall be calculated using a single
royalty rate of ****regardless of the level of Net Sales for all Updated IL-21
Patent Products;

(d) amending the article related to the representations, warranties and
covenants of ZGI to include an additional SECTION 10.2(i) stating that Appendix
3 identifies all Updated IL-21 Related Patents in the RoW that are owned or
controlled by ZGI as of January 1, 2003 and that claim: (i) ****; (ii) ****;
(iii) ****; or (iv) ****

(e) any amendments necessary to conform the License Agreement for IL-21 with
(a), (b), (c), or (d) above.

 **** designates portions of this document that have been omitted pursuant to a
request for confidential treatment filed separately with the commission.

<PAGE>

                                    ARTICLE 3
       Sharing of Costs after January 1, 2003 until ZGI's filing of an IND

SECTION 3.1. Cost Sharing. Subject to the terms of this Agreement, the parties
agree to a sharing of costs for the IL-21 Program that are incurred after
January 1, 2003 until the date of ZGI's filing of an IND pursuant to the IL-21
Program, in accordance with the following provisions:

       (a) The percentage split of such costs shall be **** activities involved
           with the IL-21 Program through ZGI's filing of an IND pursuant to the
           IL-21 Program, except as otherwise provided below;

       (b) The parties will review and agree to the IL-21 Program in support of
           ZGI's IND submission and include in this IL-21 Program activities
           solely required to make such a submission compliant with EMEA/MHW
           regulations for an equivalent submission by NN, so long as the
           inclusion of additional activities does not delay the US IL-21
           Program and the added costs are borne by NN. Reciprocally, costs for
           IL-21 Program activities incurred by ZGI solely required to support
           US FDA regulations are borne by ZGI;

       (c) Except for activities outlined in SECTION 3.1(b) above, the IL-21
           Program will be based on an agreed fixed budget currently set at
           ****. This fixed budget shall not be exceeded without the prior
           written consent of both parties. The IL-21 Program will terminate
           once costs exceed the fixed budget, unless the parties, within thirty
           (30) days of notice of such exceeded costs, otherwise agree to extend
           the fixed budget.

       (d) The parties agree that a major part of the activities of this IL-21
           Program will be undertaken by ZGI, but activities that can be
           undertaken by NN as part of this IL-21 Program and in accordance with
           agreed deliverables, budget, and time lines will be transferred to NN
           for execution. The costs incurred by NN for such transferred
           activities are shared and reimbursed in the same way that ZGI's costs
           are shared and reimbursed using, if available, the projected costs by
           ZGI or the costs incurred by NN using the same cost calculation
           principles as ZGI.

       (e) Activities that are a part of the IL-21 Program involving ZGI's IND
           submission pursuant to the IL-21 Program are included under this
           Agreement. However, the parties may agree upon additional activities
           that could be started or performed in this period that are not
           included in the IL-21 Program necessary for ZGI's IND submission
           pursuant to the IL-21 Program. It is anticipated that a contemplated
           joint development program will govern such additional activities.

**** designates portions of this document that have been omitted pursuant to a
request for confidential treatment filed separately with the commission.

<PAGE>

SECTION 3.2. Reimbursement for Costs. The reimbursement by NN for costs incurred
by ZGI described in SECTION 3.1 shall be made quarterly. ZGI shall invoice NN
quarterly, and NN shall pay each invoice within thirty (30) days after receipt
of the quarterly invoice from ZGI.

SECTION 3.3. Governance of Collaboration after January 1, 2003 until filing of
an IND. NN and ZGI shall establish the following in collaboration under this
Agreement:

      (a) Joint Steering Committee. The parties shall form a Joint Steering
          Committee consisting of three (3) members from each company. The Joint
          Steering Committee will be responsible for overseeing a joint work
          plan under the IL-21 Program. The Joint Steering Committee will also
          resolve any disputes, and create a mechanism for resolving project
          delays and approving changes. ZGI will have the tie-breaking vote
          until an IND pursuant to the IL-21 Program is filed by ZGI.

      (b) Joint Project Team. ZGI and NN shall each create their own project
          group with a designated project manager. Additionally, members of
          these groups will constitute a Joint Project Team with co-leadership
          by the two project managers. The Joint Project Team shall be governed
          by the Joint Steering Committee and will have reporting requirements
          as determined by the Joint Steering Committee. The project managers
          will serve as a primary contact, coordinate activities under the joint
          work plan under the IL-21 Program, and will oversee the tasks
          designated to their project group by the Joint Steering Committee.

      (c) Quarterly Meetings. The Joint Steering Committee and selected members
          of the Joint Project Team shall each at minimum hold quarterly
          meetings in person. In addition, the Joint Project Team shall at
          minimum hold monthly meetings in person or by videoconference, or
          teleconference in those months where there is no quarterly meeting.
          Copies of all written materials presented or discussed at such
          meetings shall be exchanged prior to such meetings between project
          managers. If it is impossible to exchange newly generated data prior
          to such meetings, such data may be exchanged promptly thereafter. The
          project managers shall keep accurate meeting minutes, with this
          responsibility alternating between the parties.

                                   ARTICLE 4
 Rights to Intellectual Property Discovered In Performance of the IL-21 Program

SECTION 4.1. Ownership of Intellectual Property. Any and all intellectual
property created, generated or developed by or on behalf of a party or its
Affiliates in the course of performance of the IL-21 Program shall vest in and
be owned and controlled to the extent possible by such party or its Affiliates,
subject to any licenses granted under this Agreement. It is the intention of the
parties that each party shall have an equal, undivided interest in all Joint
IL-21 Program Patent Rights and all IL-21 Program Inventions for which Joint
IL-21 Program Patent Rights may be sought.

<PAGE>

SECTION 4.2. Cross License. Each party hereby grants the other party an
exclusive, royalty-free, fully paid up license (including the right to
sublicense) under the IL-21 Program Patent Rights (including the Joint IL-21
Program Patent Rights) and IL-21 Program Know-How that it or its Affiliates owns
or controls to make, have made, conduct research, develop (including clinical
development), use, sample, promote, manufacture, market, sell, offer to sell,
have sold, distribute, import and export products based on IL-21 Embodiments in
the Respective Territory of the other party; provided, however, that the
foregoing license shall be non-exclusive with respect to products based on IL-21
Program Know-How after IL-21 Program Patent Rights (including the Joint IL-21
Program Patent Rights) expire and shall become non-exclusive in the event the
License Agreement for IL-21 terminates prior to expiration. Each party hereby
grants the other party a non-exclusive, royalty-free, fully paid up, worldwide
license (including the right to sublicense subject to approval by the granting
party which shall not be unreasonably withheld) under the IL-21 Program Patent
Rights and IL-21 Program Know-How that it or its Affiliates owns or controls to
make, have made, conduct research, develop (including clinical development),
use, sample, promote, manufacture, market, sell, offer to sell, have sold,
distribute, import and export products that are not based on any IL-21
Embodiments; provided that the right to sublicense Joint IL-21 Program Patent
Rights shall not require the consent of either party. The parties agree to
execute any documents necessary to give effect to the foregoing, if required by
applicable law.

SECTION 4.3. Patent Prosecution. Each party shall promptly disclose to the other
party the conception or reduction to practice of IL-21 Program Inventions for
which IL-21 Program Patent Rights (including Joint IL-21 Program Patent Rights)
may be sought. Each party shall be solely responsible, at its discretion, for
the filing and prosecution of any and all patent applications that it owns or
controls that are included in the IL-21 Program Patent Rights (including
opposition and interference proceedings) and for the maintenance of any patents
issuing thereon; provided, however, that ZGI shall be the party designated to
control the filing, prosecution, issuance and maintenance of all Joint IL-21
Program Patent Rights. Each responsible party shall be responsible for all costs
associated with such filings, prosecutions and maintenance and, at its sole
discretion, the jurisdictions in which patents may be sought; however, a party
shall promptly reimburse the other party for the costs associated with any Joint
IL-21 Program Patent Rights in its Respective Territory. With respect to IL-21
Program Patent Rights, each party shall deliver to the other party copies of
each new patent application that it files and all material documents sent to or
received from patent offices. The other party shall have a right to review and
comment on the nature and text of each document and the responsible party shall
consider in good faith any comments from the other party regarding steps that
might be taken to strengthen the patents and patents applications, provided that
all final decisions regarding the filing and prosecution of patents and patent
applications shall be within the sole discretion of the responsible party.

SECTION 4.4. Abandonment of IL-21 Program Patent Rights. With respect to the
IL-21 Program Patent Rights, if a party elects not to prosecute or maintain any
patents or patent applications in the other party's Respective Territory, the
responsible party shall provide the other party with a written notice of such
election, in which case, the other party may assume responsibility for
prosecuting or maintaining such patents or patent applications at its expense
and in the name of the responsible party. Upon requests of the other party and
at no out-of-pocket expense to the responsible party, the responsible party
shall render such reasonable

<PAGE>

assistance, execute any documents and do such other acts as may be reasonably
necessary in connection with such prosecution or maintenance.

SECTION 4.6. Cooperation. In any legal proceeding conducted under this SECTION
4, each party agrees, without charge, to render such reasonable assistance,
execute any documents and do such other acts as may be reasonably necessary in
such legal action as the other party may reasonably request.

SECTION 4.7. Know-How Disclosure. In addition to the disclosure of IL-21 Program
Inventions and IL-21 Program Patent Rights pursuant to Section 4.3, each party
shall disclose to the other party other information and data developed under the
IL-21 Program that constitutes IL-21 Program Know-How.

SECTION 4.8. Affiliates and sublicensees. Each party shall require its
Affiliates, licensees/sublicensees to comply with this ARTICLE 4.

                                  ARTICLE 5
                        Intent to Enter Further Agreement

SECTION 5.1. Intent to Enter Further Agreement. As of the Effective Date of this
Agreement and unless the IL-21 Program is terminated early, the parties intend
to negotiate a further agreement that may include further clinical and
non-clinical development towards NDA filing, as well as NN's responsibility for
production of the IL-21 Protein for late clinical and non-clinical development,
and commercialization of the IL-21 Protein. The terms of such agreement are yet
to be determined and will be negotiated in good faith between the parties.

                                    ARTICLE 6
                                 Confidentiality

SECTION 6.1. Confidential Information. For the purposes of this Agreement,
"Confidential Information" shall include all proprietary information and
materials, patentable or otherwise, of a party that is disclosed by or on behalf
of such disclosing party to the receiving party, such as DNA sequences, amino
acid sequences, vectors, cells, substances, formulations, techniques,
methodology, equipment, data, reports, know-how, assay results, preclinical
studies and clinical trials and the results thereof, patent positioning and
business plans, including any negative developments.

SECTION 6.2. Confidentiality Obligation. Except as otherwise authorized under
this Agreement, during the term of this Agreement and for a period of three (3)
years thereafter, each party shall maintain as secret and confidential all
Confidential Information obtained from the other party pursuant to this
Agreement or prior to and in contemplation of this Agreement, and all other
Confidential Information that it may acquire from the other in the course of
this Agreement. Each party shall respect the other party's proprietary rights in
such Confidential Information, use the same exclusively for the purposes of this
Agreement, and disclose the same only to those of its representatives to whom
and to the extent that such disclosure is reasonably

<PAGE>

necessary for the purposes of this Agreement. The obligations under this SECTION
6.2 shall survive the termination of this Agreement.

SECTION 6.3. Release from Confidentiality Obligation. Notwithstanding the
foregoing provision, a party shall be permitted to disclose any Confidential
Information of the other party to its patent practitioners or any patent office
in any country, as is reasonably required for filing or prosecuting any patent
application permitted to be filed by it hereunder. Furthermore, the obligations
of SECTION 6.2 shall not apply to Confidential Information that:

             (a) was properly in the possession of the receiving party, without
any restriction on use or disclosure, prior to receipt from the disclosing
party, and such possession can be demonstrated by competent evidence of the
receiving party;

             (b) is in the public domain by public use, publication, general
knowledge or the like, or after disclosure hereunder becomes general or public
knowledge through no fault of the receiving party;

             (c) is properly obtained by the receiving party from a third party
not under a confidentiality obligation;

             (d) is independently developed by or on behalf of the receiving
party without the assistance of the confidential information of the disclosing
party; or

             (e) is required to be disclosed by order of any court or
governmental or regulatory authority after notification to the disclosing party
of the necessity to allow the disclosing party to seek protection for the
disclosing party's confidential information from such court or governmental or
regulatory authority.

                                    ARTICLE 7
                                 Indemnification

SECTION 7.1. Indemnification by NN. NN will indemnify, hold harmless and defend
ZGI, and its directors, officers, employees, and agents (Collectively, the "ZGI
Indemnitees") against all actions, suits, claims, demands and prosecutions
(hereinafter a "Claim") that may be brought or instituted, and all judgments,
damages, liabilities, costs and expenses resulting directly therefrom, arising
out of the performance by NN under this Agreement and exercise of its license
rights under this Agreement. NN's indemnification obligations under this SECTION
will arise only if ZGI (i) notifies NN promptly after it becomes aware of a
Claim; (ii) permits NN to control the defense and settlement, at NN's expense,
of any such Claim; and (iii) does not settle any such Claim without the prior
written approval and consent of NN, which consent shall not be unreasonably
withheld.

SECTION 7.2. Indemnification by ZGI. ZGI will indemnify, hold harmless and
defend NN, and its directors, officers, employees, and agents (Collectively, the
"NN Indemnitees") against all actions, suits, claims, demands and prosecutions
(hereinafter a "Claim") that may be brought or instituted, and all judgments,
damages, liabilities, costs and expenses resulting directly

<PAGE>

therefrom, arising out of the performance by ZGI under this Agreement and
exercise of its license rights under this Agreement. ZGI's indemnification
obligations under this SECTION will arise only if NN (i) notifies ZGI promptly
after it becomes aware of a Claim; (ii) permits ZGI to control the defense and
settlement, at ZGI's expense, of any such Claim; and (iii) does not settle any
such Claim without the prior written approval and consent of ZGI, which consent
shall not be unreasonably withheld.

                                    ARTICLE 8
                              Term and Termination

SECTION 8.1. Term and Expiration. This Agreement shall come into force on the
Effective Date. Unless terminated earlier, this Agreement shall expire on the
date on which ZGI files an IND pursuant to the IL-21 Program or until the last
to expire of any IL-21 Program Patent Right, whichever is longest. Upon
expiration or termination certain rights and obligations shall survive as
defined in SECTION 8.8 below.

SECTION 8.2. Non-Viability. Each party shall have the right to terminate the
IL-21 Program, which shall automatically terminate the licenses that the
terminating party received from the other party under ARTICLE 4, upon three (3)
months prior written notice to the other party with an explanation contained
therein if, in the reasonable opinion of their respective senior management, the
commercialization of IL-21 Protein must be terminated for safety or efficacy
reasons based on one or more substantial safety or efficacy studies. In such
event, each party shall be obligated to pay to the other party all obligations
that are accrued under this Agreement prior to termination. In addition, the
IL-21 Program Patent Rights of the terminating party shall be assigned to the
non-terminating party unless termination under this SECTION 8.2 is mutually
agreed upon by the parties. Termination under this SECTION 8.2 shall not release
either party from any obligations accrued prior thereto.

SECTION 8.3. Insolvency. Each party shall have the right to terminate the IL-21
Program, which shall automatically terminate the licenses that the terminating
party granted to the other party under ARTICLE 4, after written notice to the
other party (a) if the other party is declared insolvent or bankrupt by a court
of competent jurisdiction, (b) if a voluntary or involuntary petition in
bankruptcy is filed in any court of competent jurisdiction against the other
party and such petition remains undismissed, undischarged or unbonded for a
period of ninety (90) days after the filing thereof, or (c) if the other party
shall make or execute an assignment for the benefit of creditors generally, have
a receiver, administrator or an equivalent official appointed with respect to
its properties or undertakings, enter into any liquidation or become insolvent.
Termination under this SECTION 8.3 shall not release either party from any
obligations accrued prior thereto.

SECTION 8.4. Breach. Each party shall have the right to terminate this Agreement
after written notice to the other party in the event the other party is in
material breach of this Agreement (including action or inaction resulting in
unreasonable delay of the IL-21 Program, or failure to timely pay any amounts
due hereunder), unless the other party cures such breach within sixty (60) days
(or ten (10) days in the case of the failure to pay any amount due) after the
date of

<PAGE>

notice; provided, however, that any termination shall not release either party
from any obligations accrued prior thereto.

SECTION 8.5. Mutual Agreement. The parties shall have the right to terminate
this Agreement upon mutual agreement in writing, provided, however, that any
termination shall not release either party from any obligations accrued prior
thereto.

SECTION 8.6. Termination of the IL-21 Program. Each Party shall have the right
to terminate the IL-21 Program without affecting any other rights and
obligations under this Agreement, if ZGI for whatever reason has not filed an
IND within two (2) years after the Effective Date. The IL-21 Program also
terminates as provided in SECTIONS 3.1(c), 8.2, and 8.3. Termination of the
IL-21 Program pursuant to SECTIONS 3.1(c), 8.4, 8.5, and 8.6 shall not terminate
the licenses granted or received under ARTICLE 4. Termination of the IL-21
Program under SECTIONS 3.1(c), 8.2, 8.3, 8.4, 8.5 and 8.6 shall not release
either party from any obligations accrued prior thereto, including the
obligation to provide information and documentation generated prior to such
termination and any final reports based on such information and documentation.

SECTION 8.7. Automatic Termination of the Agreement. This Agreement shall
automatically terminate if NN fails to pay to ZGI when due (or within 10 days
after written notice of past due) the full amount due from NN pursuant to
SECTIONS 2.1 and 2.2 (including the one-half amount that is due upon, or becomes
nonrefundable upon, satisfaction of the demonstration obligations set forth in
SECTION 2.3); provided, however, that any termination shall not release either
party from any obligations accrued prior thereto. Furthermore, this Agreement
shall automatically terminate if the IL-21 Program terminates pursuant to this
Agreement. Termination under this SECTION 8.7 shall not release either party
from any obligations accrued prior thereto.

SECTION 8.8. Effect of Expiration or Termination. Expiration or termination of
this Agreement shall not relieve the parties of any obligations accruing prior
to such expiration or termination. In addition to any provision that expressly
provides for its survival, any accrued obligations and the provisions of
ARTICLES 1, 4 (as modified by this ARTICLE 8), 6, 7 and 10 and SECTIONS 3.2
(i.e., costs through termination), 8.9, 9.3 and 9.4 shall survive the expiration
or termination of this Agreement. Expiration or termination shall not affect any
party's ability to seek any other remedies available at law.

SECTION 8.9. Return of Technical Information. Upon termination but not
expiration of this Agreement prior to payment by NN to ZGI of the full amount
due pursuant to SECTIONS 2.1 and 2.2, NN shall cause all materials containing
any Confidential Information of ZGI conveyed to NN pursuant to ARTICLE 2 to be
promptly delivered to ZGI. Upon termination but not expiration of this Agreement
during the IL-21 Program due to a party's (the "Defaulting Party's") failure to
reimburse the other party for its costs pursuant to SECTIONS 3.1 and 3.2, the
Defaulting Party shall cause all materials containing any of the other party's
IL-21 Program Patent Rights and IL-21 Program Know-How to be promptly delivered
to the other party, and the Defaulting Party's license rights thereto under
SECTION 4.2 shall be terminated. Upon termination of the IL-21 Program under
SECTION 8.2 or 8.3, the party losing its license rights under ARTICLE 4 shall
cause all materials containing any of the other party's IL-21 Program

<PAGE>

Patent Rights and IL-21 Program Know-How, except for Joint IL-21 Program Patent
Rights, to be promptly delivered to the other party.

                                    ARTICLE 9
                         Representations and Warranties

SECTION 9.1. Representations, Warranties and Covenants of NN. NN represents and
warrants to and covenants with ZGI that:

             (a) NN is a corporation duly organized, validly existing and in
corporate good standing under the laws of Denmark; and

             (b) NN has the corporate and legal right, title, authority and
power to enter into this Agreement; and

             (c) NN has taken all necessary action to authorize the execution,
delivery and performance of this Agreement; and

             (d) upon the execution and delivery of this Agreement, this
Agreement shall constitute a valid and binding obligation of NN, enforceable in
accordance with its terms, except as enforceability may be limited by applicable
bankruptcy, insolvency, reorganization, moratorium or similar laws affecting
creditors' and contracting parties' rights generally and except as
enforceability may be subject to general principles of equity (regardless of
whether such enforceability is considered in a proceeding in equity or at law);
and

             (e) the performance of its obligations under this Agreement will
not conflict with or result in a breach of any agreements, contracts or other
arrangements to which it is a party; and

             (f) NN will not during the term of this Agreement enter into any
agreements, contracts or other arrangements that would prevent NN from meeting
its obligations or adversely impact ZGI's rights under this Agreement;
and

             (g) NN will comply with all applicable laws, regulations and
guidelines in connection with the exercise of NN's license rights under this
Agreement, including but not limited to all applicable product safety, product
testing, product labeling, package marking and product advertising laws and
regulations and the regulations of any relevant nations concerning any export or
other transfer of technology, services or products.

SECTION 9.2. Representations, Warranties and Covenants of ZGI. ZGI represents
and warrants to and covenants with NN that:

             (a) ZGI is a corporation duly organized, validly existing and in
corporate good standing under the laws of the state of Washington; and

             (b) ZGI has the corporate and legal right, title, authority and
power to enter into this Agreement; and

<PAGE>

             (c) ZGI has taken all necessary action to authorize the execution,
delivery and performance of this Agreement; and

             (d) upon the execution and delivery of this Agreement, this
Agreement shall constitute a valid and binding obligation of ZGI enforceable in
accordance with its terms, except as enforceability may be limited by applicable
bankruptcy, insolvency, reorganization, moratorium or similar laws affecting
creditors' and contracting parties' rights generally and except as
enforceability may be subject to general principles of equity (regardless of
whether such enforceability is considered in a proceeding in equity or, at law);
and

             (e) the performance of its obligations under this Agreement will
not conflict with or result in a breach of any agreements, contracts or other
arrangements to which it is a party; and

             (f) ZGI will not after the Effective Date enter into any
agreements, contracts or other arrangements that would prevent ZGI from meeting
its obligations or adversely impact NN's rights under this Agreement;

             (g) ZGI will comply with all applicable laws, regulations and
guidelines in connection with the performance of ZGI's obligations under this
Agreement.

SECTION 9.3. Warranty Disclaimer. EXCEPT AS OTHERWISE EXPRESSLY PROVIDED IN THIS
AGREEMENT, NEITHER PARTY MAKES ANY WARRANTY WITH RESPECT TO ZGI'S RESEARCH AND
DEVELOPMENT PROGRAM PRIOR TO JANUARY 1, 2003 (INCLUDING THE DEMONSTRATION
OBLIGATIONS DESCRIBED IN SECTION 2.3), THE IL-21 PROGRAM, IL-21 PROGRAM PATENT
RIGHTS, IL-21 PROGRAM KNOW-HOW, IL-21 EMBODIMENTS, PRODUCTS, UPDATED IL-21
RELATED PATENTS, UPDATED IL-21 RELATED KNOW-HOW OR OTHER SUBJECT MATTER OF THIS
AGREEMENT AND HEREBY DISCLAIMS WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE, NON-INFRINGEMENT AND PATENTABILITY WITH RESPECT TO ANY AND
ALL OF THE FOREGOING.

SECTION 9.4. Limited Liability. EXCEPT IN THE CASE OF GROSS NEGLIGENCE OR
WILLFUL MISCONDUCT, NEITHER NN NOR ZGI WILL BE LIABLE WITH RESPECT TO ANY MATTER
ARISING UNDER THIS AGREEMENT UNDER ANY CONTRACT, NEGLIGENCE, STRICT LIABILITY OR
OTHER LEGAL OR EQUITABLE THEORY FOR ANY PUNITIVE OR EXEMPLARY DAMAGES.

<PAGE>

                                   ARTICLE 10
                                  Miscellaneous

SECTION 10.1. Assignment. This Agreement may not be assigned by either party
without prior written consent of the other party, except to a successor or a
purchaser of all or substantially all of the party's assets and business or to
an Affiliate; provided, however, that in the event of an assignment by NN to an
Affiliate, the Affiliate's rights under this Agreement shall terminate once it
ceases being an "Affiliate" of NN (however, its rights may be reassigned back to
NN at the time it ceases being an "Affiliate" of NN). If, as a result of any
assignment of any rights or interest in this Agreement by NN, any payment by or
on behalf of NN to ZGI is subject to an increased level of tax withholding than
would have been the case under this Agreement with payments by NN from Denmark
and ZGI cannot use any related tax credit as an offset against its obligation to
pay United States federal income tax in the year in which the withholding is
effected, NN shall pay ZGI an amount such that, after deduction of any amount
required to be withheld, ZGI receives the same amount that it would have
received but for the assignment. In the event of any permissible assignment
under this Agreement, the assignor and assignee shall be jointly and severally
liable for assignor's obligations hereunder. ZGI shall have the right to assign
its right to receive any payments under this Agreement.

SECTION 10.2. Relationship between the Parties. Nothing in this Agreement is
intended to create or shall be deemed to constitute a partnership, agency or
joint venture relationship between the parties or their sublicensees,
contractors or licensees. Neither party shall be responsible for the acts or
omissions of the other party, and neither party shall have the authority to
speak for, represent or obligate the other party in any way without the prior
written authority of the other party.

SECTION 10.3. Public Announcements. Neither party shall make any public
announcement, written or oral, concerning this Agreement or the subject matter
hereof, without the prior written approval of the other party. However, ZGI
shall have the right to disclose or announce information concerning the
existence and general nature of this Agreement in order to seek third party
investors in ZGI provided that disclosure of any confidential information shall
only be made under an obligation or expectation of confidentiality. Further, the
parties shall have the right to disclose or announce information concerning the
existence and general nature of this Agreement in order to comply with
government law or regulations, provided that the other party is given prior
written notice of such disclosure or announcement.

SECTION 10.4. Use of Names, Trade Names and Trademarks. Except as provided
herein, nothing contained in this Agreement shall be construed as conferring any
right on either party to use in advertising, publicity or other promotional
activities any name, trade name, trademark or other designation of the other
party hereto, including any contraction, abbreviation or simulation of any of
the foregoing, unless the express written permission of such other party has
been obtained.

SECTION 10.5. Force Majeure. If either party to this Agreement is prevented or
delayed in the performance of any of its obligations under this Agreement by
force majeure, and if such party gives written notice thereof to the other party
specifying the matters constituting force majeure,

<PAGE>

together with such evidence as it can reasonably give and specifying the period
for which it is estimated that such prevention or delay will continue, then the
party in question shall be excused from the performance of its obligations or
the punctual performance thereof as the case may be as from the date of such
notice for so long as such cause of prevention or delay shall continue. For the
purpose of this Agreement, "force majeure" shall be deemed to be any cause
affecting the performance of this Agreement arising from or attributable to
acts, events, omissions or accidents beyond the reasonable control of the party.

SECTION 10.6. Governing Law. This Agreement shall be governed in all respects by
the laws of the State of Washington (without regard to its choice of law
provisions).

SECTION 10.7. Waiver of Remedies. No forbearance, delay or indulgence by either
party in enforcing the provisions of this Agreement shall prejudice or restrict
the rights of that party, nor shall any waiver of its rights operate as a waiver
of any subsequent breach, and no right, power or remedy herein conferred upon or
reserved for either party is exclusive of any other right, power or remedy
available to that party.

SECTION 10.8. Entire Agreement. This Agreement constitutes the entire agreement
between the parties and supersedes all prior oral and written agreements,
understandings or arrangements relating to the subject matter hereof. No
addition to or modification of any provision of this Agreement shall be binding
upon the parties, unless made in writing and signed by a duly authorized
representative of each of the parties.

SECTION 10.9. Notices. All notices or other communication hereunder shall be in
writing and shall be deemed to have been duly given if delivered personally,
faxed with receipt acknowledged (and with a confirmation copy also sent by
registered mail, return receipt requested), or delivered by a recognized
commercial courier service with receipt acknowledged, postage prepaid, as
follows:

     If to NN:         Novo Nordisk A/S
                       Novo Alle
                       DK-2880 Bagsvaerd
                       Denmark

                       Attn: Chief Scientific Officer & Executive Vice President
                       Research & Development
                       Facsimile:  +45 44 42 72 80

     With a copy to:   Novo Nordisk Legal Department
                       Novo Alle
                       DK-2880 Bagsvaerd
                       Denmark

                       Facsimile: +45 4498 0670

                       and

<PAGE>

                                 Senior Vice President, Discovery
                                 Novo Alle
                                 DK-2880 Bagsvaerd
                                 Denmark

                                 Facsimile: 45 4444 45 65:

         If to ZGI:              ZymoGenetics, Inc.
                                 1201 Eastlake Avenue East
                                 Seattle, WA  98102
                                 Attn: Vice President, Intellectual Property
                                 and Legal Affairs
                                 Facsimile: (206) 442-6697

or to such other addresses as the addressee may have specified in a notice duly
given to the sender as provided herein. Such notices or other communication will
be deemed effective as of the date so delivered (either personally or by courier
service) or faxed.

SECTION 10.10. Severability. The parties agree that, if any provision of this
Agreement shall for any reason be held to be invalid or unenforceable, such
provision shall be enforced to the maximum extent permitted by law and the
parties' fundamental intentions hereunder, and the remaining provisions hereof
shall not be affected, impaired or invalidated and shall continue in full force
and effect.

SECTION 10.11. Headings. The headings contained herein are for reference only
and shall not be considered a part of this Agreement, nor shall they in any way
affect the interpretation hereof.

SECTION 10.12. Review of Agreement. This Agreement has been submitted to the
scrutiny of both parties and their counsel and shall be given a fair and
reasonable interpretation in accordance with the words hereof, without
consideration or weight being given to its being drafted by or for one of the
parties.

SECTION 10.13. Compliance with Laws; Export Regulations. In performance of this
Agreement, each party shall comply with all laws, regulations, rules, orders and
other requirements, now or hereafter in effect, governmental authorities having
jurisdiction. This Agreement and any information provided hereunder are subject
to restrictions concerning the export of information and materials that may be
imposed by government. Accordingly, NN agrees that it will not export, directly
or indirectly, any information or materials acquired under this Agreement or any
products utilizing such information or materials to any country for which a
government or any agency thereof at the time of export requires an export
license or other governmental approval, without first obtaining the written
consent to do so from the appropriate agency of the government when required by
an applicable statute or regulation.

SECTION 10.14. Counterparts. This Agreement may be executed in two or more
counterparts each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

<PAGE>

[Balance of page intentionally left blank.]

<PAGE>

IN WITNESS WHEREOF, the parties have caused this Agreement to be duly executed
as of the date first above written.

                                         ZymoGenetics, Inc.

                                         By:  /s/ Bruce L.A. Carter
                                             -----------------------------------
                                             Bruce L.A. Carter

                                             Chief Executive Officer



                                         Novo Nordisk A/S

                                         By:  /s/ Peter Kurtzhals
                                            ------------------------------------
                                                  Peter Kurtzhals
                                                  Senior V.P. Discovery



                                         By:  /s/ M. Krogsgaard Thomsen
                                            ------------------------------------
                                                  M. Krogsgaard Thomsen

                                                  Chief Science Officer and
                                                  Executive Vice President,
                                                  Research and Development

<PAGE>

                                      ****



**** designates portions of this document that have been omitted pursuant to a
request for confidential treatment filed separately with the commission.

</TEXT>
</DOCUMENT>
