INTERMUNE PHARMACEUTICALS INC
EXHIBIT 10.38
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<TYPE>EX-10.38
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<DESCRIPTION>EXHIBIT 10.38
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<BR></FONT><FONT SIZE=2><B>Exhibit 10.38    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;
January&nbsp;25, 2001 </FONT></P>


<P><FONT SIZE=2>Ms.&nbsp;Anna
Hall<BR>
Director of Business Development<BR>
Genentech,&nbsp;Inc.<BR>
1 DNA Way<BR>
South San Francisco<BR>
CA 94080-4990 </FONT></P>

<P><FONT SIZE=2><B>RE:&nbsp;&nbsp;&nbsp;&nbsp;AMENDMENT NO.&nbsp;5 TO THE INTERMUNE/GENENTECH LICENSE AGREEMENT</B></FONT></P>

<P><FONT SIZE=2>Dear
Ms.&nbsp;Hall: </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Please
consider this document as Amendment No.&nbsp;5 to that certain License Agreement for Interferon Gamma, dated May&nbsp;5, 1998; as amended on December&nbsp;26, 1998;
January&nbsp;15, 1999; April&nbsp;27, 1999; and June&nbsp;23, 2000 (collectively, the "Agreement"), between </FONT><FONT SIZE=2><B>INTERMUNE PHARMACEUTICALS, INC</B></FONT><FONT SIZE=2>. and </FONT> <FONT SIZE=2><B>GENENTECH,
&nbsp;INC.</B></FONT><FONT SIZE=2> (collectively, the "Parties"). </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT
SIZE=2><B>1.</B></FONT><FONT SIZE=2>&nbsp;&nbsp;The Parties agree that the first sentence of Section&nbsp;2.2(b) of the Agreement is hereby terminated in its
entirety and amended and superseded as follows: </FONT></P>

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<UL>
<DL compact>
<DT><FONT SIZE=2>"(b)</FONT></DT><DD><FONT SIZE=2>Use
of the Mark. In using the Actimmune mark, InterMune shall display said mark with either the first letter in uppercase (i.e., Actimmune) or all letters in uppercase (i.e.,
ACTIMMUNE)." </FONT></DD></DL>
</UL>
</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT
SIZE=2><B>2.</B></FONT><FONT SIZE=2>&nbsp;&nbsp;All other sections and exhibits of the Agreement remain unchanged. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT
SIZE=2><B>3.</B></FONT><FONT SIZE=2>&nbsp;&nbsp;This Amendment No.&nbsp;5 to the Agreement is made effective as of January&nbsp;25, 2001. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT
SIZE=2><B>IN WITNESS THEREOF</B></FONT><FONT SIZE=2>, the parties have executed this Amendment No.&nbsp;5 to the Agreement as of the date set forth below. </FONT></P>

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<TD COLSPAN=3 VALIGN="TOP"><FONT SIZE=2><B>INTERMUNE PHARMACEUTICALS, INC.</B></FONT></TD>
<TD WIDTH="3%" VALIGN="TOP"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD COLSPAN=3 VALIGN="TOP"><FONT SIZE=2><B>GENENTECH, INC.</B></FONT></TD>
</TR>
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<TD WIDTH="6%"><FONT SIZE=2><BR>
By</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="37%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>JOHN J. WULF</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> John Wulf<BR>
Sr. Vice President of Corporate Development</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="13%"><FONT SIZE=2><BR>
By</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="37%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>JOSEPH S. MCCRACKEN</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE></TD>
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<TD WIDTH="6%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
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&nbsp;</FONT></TD>
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Print Name</FONT></TD>
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Joseph S. McCracken</FONT><HR NOSHADE></TD>
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&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
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&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="13%"><FONT SIZE=2><BR>
Title</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="37%" ALIGN="CENTER"><FONT SIZE=2><BR>
VP BUSINESS DEVELOPMENT</FONT><HR NOSHADE></TD>
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Date</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
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January 25, 2001</FONT><HR NOSHADE></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
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Date</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="37%" ALIGN="CENTER"><FONT SIZE=2><BR>
4/5/01</FONT><HR NOSHADE></TD>
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