BOSTON BIOMEDICA INC
EXHIBIT 10.33
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<DESCRIPTION>EXHIBIT 10.33
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<TITLE>First Amendment to BBI Source Scientific, Inc. Lease Agreement</TITLE>
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<P ALIGN=RIGHT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Exhibit 10.33</FONT></P>

<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>FIRST
AMENDMENT TO LEASE</FONT></H1>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>THIS
FIRST AMENDMENT TO LEASE</B> (this &#147;<B>First Amendment</B>&#148;) is dated
as of December 12, 2001, between CABOT INDUSTRIAL PROPERTIES, L.P., a Delaware
limited partnership (&#147;<B>Landlord</B>&#148;) and BBI-SOURCE SCIENTIFIC,
INC., a Massachusetts corporation (&#147;<B>Tenant</B>&#148;). </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A.&nbsp;&nbsp;&nbsp;
TR Brell Cal Corp, Landlord&#146;s predecessor-in-interest, and Source
Scientific, Inc., Tenant&#146;s predecessor-in-interest, entered into that
certain Standard Industrial/Commercial Single-Tenant Lease-Net dated January 30,
1995 (the &#147;<B>Original Lease</B>&#148;) and that certain addendum attached
thereto (the &#147;<B>Addendum</B>&#148;) with respect to certain premises
located at 7390 Lincoln Way, Garden Grove, California. The term
&#147;<B>Lease</B>&#148; as used herein shall mean the Original Lease as amended
by the Addendum. Unless otherwise defined in this First Amendment,
initially-capitalized terms used herein shall have the meanings set forth in the
Lease. </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B.&nbsp;&nbsp;&nbsp;
Landlord and Tenant desire to amend the Lease on the terms and conditions set forth herein.</FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NOW
THEREFORE, in consideration of the foregoing Recitals, the mutual covenants and
agreements contained herein, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant
agree, and amend the Lease as follows: </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.&nbsp;&nbsp;&nbsp;
<U>Premises</U>.&nbsp;&nbsp;&nbsp;As of February 1, 2002, the parties desire to decrease the size
of the space subject to the Lease from 41,184 square feet to 27,165 square feet.
Accordingly, as of February 1, 2002, the definition of Premises in Section 1.2
of the Lease shall be deleted in its entirety and replaced with the following: </FONT></P>

<p><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.2&nbsp;&nbsp;&nbsp;
<B>Premises</B>:&nbsp;&nbsp;&nbsp;Approximately 27,165 square feet of space commonly known as a
portion of 7390 Lincoln Way, Garden Grove, California, as more particularly
described in <U>Exhibit A</U> attached hereto and incorporated herein by this
reference. The term &#147;Property&#148; shall mean that certain real property
of which the Premises are a part more particularly described in <U>Exhibit
A-1</U> attached hereto and incorporated herein by this reference. </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.&nbsp;&nbsp;&nbsp;
<U>Term.</U>&nbsp;&nbsp;&nbsp;The Term of the Lease is hereby  extended for a period of three (3) years.  Accordingly,  the Term shall expire
on January 31, 2005.  Section 1.3 of the Lease is hereby deleted in its entirety and replaced with the following:</FONT></P>

<p><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.3&nbsp;&nbsp;&nbsp;
<B>Term</b>:&nbsp;&nbsp;&nbsp;Ten (10) years ("Original  Term")  commencing on February 1, 1995  ("Commencement  Date") and
         ending on January 31, 2005 ("Expiration Date").</FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.&nbsp;&nbsp;&nbsp;
<U>Base Rent</U>.&nbsp;&nbsp;&nbsp;Base Rent for the period from February 1, 2002 through January 31, 2005 shall be as set forth below:</FONT></P>

<CENTER><IMG SRC="rent_table.gif"></CENTER>
<BR>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.&nbsp;&nbsp;&nbsp;
<U>Operating  Expenses</U>.&nbsp;&nbsp;&nbsp;The following  sentences  are hereby added to the end of the second  paragraph of Section 52 of
the Addendum:</font></P>
<BR>
<BR>
<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=5%>&nbsp;</TD>
<TD WIDTH=95%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As
of February 1, 2002, Tenant shall pay its Pro Rata Share (as hereinafter
defined) of all Operating Expenses. The term &#147;<B>Pro Rata Share</B>&#148;
shall mean the quotient obtained by dividing the Premises square footage by the
Property square footage, which is leased or held for lease by tenants, as of the
date on which the computation shall be made. Tenant&#146;s Pro Rata Share
initially shall be 65.96% and is subject to adjustment based on the
aforementioned formula. </FONT>
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<BR>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.&nbsp;&nbsp;&nbsp;
<U>Use of Mezzanine by Other Tenants/Access</U>.&nbsp;&nbsp;&nbsp;Tenant acknowledges and agrees
that as of February 1, 2002 the mezzanine which is a part of the Property (the
&#147;<B>Mezzanine</B>&#148;) may be used by other tenants. In addition, such
other tenants shall have the right to have access to and from the Mezzanine,
including, without limitation, use of entrances to the Property or Premises and
use of the stairway leading to the Mezzanine. Such access may include common
access areas over and through a portion of the Premises. In such case, certain
portions of the Premises may become common areas that shall be used by such
other tenants concurrently with Tenant. If any part of the Premises is
determined to be part of the common area, then Tenant&#146;s Pro Rata Share
shall be adjusted according to the above-mentioned formula. In no case, however,
shall the monthly Base Rent be adjusted due to an change in the Pro Rata Share.
If Landlord leases the Mezzanine to another tenant, Landlord shall pay for any
costs associated with separately metering or (sub-metering) the Mezzanine for
electricity. Tenant shall cooperate with Landlord in Landlord&#146;s efforts to
separately meter the Mezzanine. In addition, any tenant occupying space in the
Mezzanine shall pay for the cost of any security system that such tenant
installs. </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.&nbsp;&nbsp;&nbsp;
<U>No Option to Extend Term</U>.&nbsp;&nbsp;&nbsp;Section 62 of the Addendum to the Lease is hereby  deleted in its  entirety.  Landlord and
Tenant acknowledge and agree that Tenant shall not have the option to extend the Term of the Lease.</FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.&nbsp;&nbsp;&nbsp;
<U>Exhibits A and A-1</U>.&nbsp;&nbsp;&nbsp;Exhibit A to the Lease is hereby  deleted in its  entirety  and  replaced  with Exhibit A and Exhibit A-1
attached hereto.</FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.&nbsp;&nbsp;&nbsp;
<U>Right of First Refusal.</U>&nbsp;&nbsp;&nbsp;If Landlord should enter into a letter of intent (an
&#147;LOI&#148;) with another tenant to lease the Mezzanine, Tenant shall have
and is hereby granted a right of first refusal to lease the Mezzanine upon the
same terms and conditions set forth in the LOI; <U>provided, that</U> (i) Tenant
gives written notice to Landlord of Tenant&#146;s election to exercise such
right no later than five (5) business days after Landlord has delivered a copy
of LOI to Tenant; (ii) no default has occurred under the Lease, and no event
exists at the time of the exercise of such right or arises subsequent thereto,
which event by notice and/or the passage of time would constitute a default
under the Lease if not cured within the applicable cure period; and (iii) Tenant
has not assigned its interest in the Lease or sublet any portion of the
Premises. Within ten (10) days after Tenant&#146;s election to lease the
Mezzanine, Landlord and Tenant shall enter into an amendment (the
&#147;Amendment&#148;) to the Lease, adding the Mezzanine to the Premises and
reflecting the terms and conditions of the LOI. If Tenant fails to execute and
deliver to the Landlord the Amendment by the expiration of such ten (10) day
period, then Tenant shall be deemed to have waived its right to lease the
Mezzanine and Landlord shall have the right to lease the Mezzanine to any other
tenant, including a tenant other than the original tenant named in the LOI, on
any terms the Landlord desires, including terms other than those set forth in
the LOI. </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.&nbsp;&nbsp;&nbsp;
<U>Brokers</U>.&nbsp;&nbsp;&nbsp;Landlord and Tenant represent and warrant to each other that
they have had no dealings with any real estate broker in connection with this
First Amendment other than Voit Commercial Brokerage, as Landlord&#146;s broker
(&#147;<B>Landlord&#146;s </B>Broker&#148;) and The Staubach Company, as
Tenant&#146;s broker. Each party (the &#147;<B>Indemnifying Party</B>&#148;)
hereby agrees to indemnify and defend the other party from any claim of any
other broker who claims entitlement to a commission because of such
broker&#146;s dealings with the Indemnifying Party. </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.&nbsp;&nbsp;&nbsp;
<U>Governing  Law</U>.&nbsp;&nbsp;&nbsp;This First  Amendment  shall be governed by, and construed and enforced in accordance  with, the laws
of the State of California.</FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.&nbsp;&nbsp;&nbsp;
<U>Counterparts</U>.&nbsp;&nbsp;&nbsp;This First Amendment may be executed in any number of
counterparts, each of which when so executed and delivered shall be deemed to be
an original and all of which counterparts taken together shall constitute but
one and the same instrument. Signature pages may be detached from the
counterparts and attached to a single copy of this First Amendment to physically
form one document. </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12.&nbsp;&nbsp;&nbsp;
<U>Reaffirmation of Obligations</U>.&nbsp;&nbsp;&nbsp;Tenant hereby acknowledges and reaffirms
all of its obligations under the Lease, as such Lease has been amended by this
First Amendment, and agrees that any reference made in any other document to the
Lease shall mean the Lease as amended pursuant to this First Amendment. Tenant
acknowledges that Landlord is not now in default of any obligation under the
Lease. Except as expressly provided herein, the Lease remains unmodified and in
full force and effect. Any breach by Tenant of this First Amendment shall
constitute a breach and default by Tenant under the Lease. </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.&nbsp;&nbsp;&nbsp;
<U>Time of Essence</U>.&nbsp;&nbsp;&nbsp;Time is of the essence with respect to each provision of this First Amendment.</FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;14.&nbsp;&nbsp;&nbsp;
<U>Exhibits</U>.&nbsp;&nbsp;&nbsp;All exhibits  attached hereto are hereby  incorporated  herein by this reference as though set out in full
herein.</FONT></P>

<P Align=center><FONT FACE="Times New Roman, Times, Serif" SIZE=2>[ remainder of page intentionally blank ]</font></p>



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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IN
WITNESS WHEREOF, Landlord and Tenant have caused this First Amendment to be duly
executed and delivered as of the date first above written. <BR>
<BR>
<BR>
"Tenant"<BR>
<BR>
BBI-SOURCE SCIENTIFIC, INC.,<BR>
a Massachusetts corporation<BR>
<BR>
<BR>
<BR>
By:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;_________________________<BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Its:______________________<BR>
<BR>
<BR>
"Landlord"<BR>
<BR>
CABOT INDUSTRIAL PROPERTIES, L.P.,<BR>
a Delaware limited partnership<BR>
<BR>
By:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Cabot Industrial Trust,<BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;its general partner<BR>
<BR>
<BR>
<BR>
By:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;_________________________<BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Its:______________________</FONT></P>


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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>EXHIBIT A</FONT></H1>

<P Align=center><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The Premises<BR>
<BR>
                                                [Exhibit not attached in EDGAR filing]</font></P>



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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>EXHIBIT A-1</FONT></H1>

<P Align=center><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The Property<BR>
<BR>                                                [Exhibit not attached in EDGAR filing]</font></P>










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