PATIENT INFOSYSTEMS INC
10.49
<DOCUMENT>
<TYPE>EX-10
<SEQUENCE>8
<FILENAME>lease.txt
<DESCRIPTION>10.49
<TEXT>
                             NINTH ADDENDUM TO LEASE

This Ninth  Addendum to Lease is made and  entered  into the 7th day of January,
2002,   between  Conifer  Prince  street   Associates   (Landlord)  and  Patient
Infosystems, Inc. formerly DSMI Corporation (Tenant).

WITNESSETH:  that Tenant currently leases and occupies approximately 7061 square
feet of office space at 46 Prince Street,  Rochester, New York 14607 pursuant to
a Lease Agreement and First, Second,  Third,  Fourth, Fifth and Sixth,  Seventh,
and Eighth Addenda To Lease, dated February 22, 1995; August 18, 1995;  November
17, 1995;  March 28, 1996;  October 29,  1996,  November 30, 1996,  November 24,
1997, and June 16, 1999 and December 2001 respectively.

WHEREAS,  Tenant and Landlord  desire to extend the Term of the Lease until June
30, 2002 leasing  occupied  space on the first floor  consisting of 5,504 square
feet for 6 additional  months and leasing  occupied  space on the lower level of
1557 square feet on a month to month basis.

NOW,  THEREFORE,  it is mutually  agreed  upon by Landlord  and Tenant to modify
Certain provisions of the Lease as follows:

1.   Effective upon full execution of this Eighth Addendum to Lease, the Term of
     the Lease shall be extended  for 6 months from  January 1, 2002 to June 30,
     2002.  for 5504 square feet of first floor space.  Tenant  wishes to occupy
     lower level of 1557 square feet of space on a month-to-month basis.

2.   Tenant  agrees to allow  Landlord  to show both first floor space and lower
     level space to prospective  new tenants with prior  notification to Patient
     Info Systems.

3.   Tenant  agrees to pay,  Base Rent for its' leased  premises,  consisting of
     approximately  5504  square  feet,  and 1557  square feet of month to month
     space as follows:

<TABLE>
<CAPTION>
                                       Annual             Monthly
            Period             Per Sq.ft.   Base Rent    Base Rent
                               ----------   ---------    ---------
<S>                              <C>         <C>          <C>
        1/1/2002-/30/2002        $15.60      $7155.20     5504sf
       1/1/2002---month to month $15.60      $2024.10     1557sf
</TABLE>


3.   Parking  permits  will  be  available  for 20 cars  from  9:00 am - 5:00 pm
     weekdays and 28 passes for evening and after hours shifts.

5.   Effective  January 1, 2001,  Schedule  A-8 shall  replace  Schedule  A7 and
     Tenant's Pro Rata share of taxes,  utilities and  insurance  will be 18.13%
     and 5.12% respectfully.

Except as modified above,  all other terms and conditions of the Lease Agreement
and  First,  Second,  Third,  Fourth,  Fifth and Sixth  Addenda  to Lease  dated
February 22, 1995; August 18, 1995;  November 17, 1995; March 28, 1996;  October
29, 1996 and November 30,  1996,  November 24, 1997,  June 16, 1999 and December
2001 respectively, shall remain unchanged and in full force and effect.

Agreed to by:                                Agreed to by:
PATIENT INFOSYSTEMS, INC.                    CONIFER PRINCE STREET ASSOCIATES
formerly DSMI CORPORATION



By:
   ------------------------------------------
By:
---------------------------------------------



Date:
     ----------------------------------------
Date:
---------------------------------------------

<PAGE>

                                  SCHEDULE A-8

                             COMMON AREA MAINTENANCE
                                 ADDITIONAL RENT
                                    UTILITIES

Total  Square Footage of Building:     30,375

Square Footage Covered By Lease:        5,504

Tenant's Share Electric:                18.13%

Month to Month portion (additional LL)  1,557
   square feet share ofelectric          5.12%

                                 ADDITIONAL RENT
Heating and Air Conditioning

The heat pump units serving the leased premises shall be individually gauged and
the monthly charges shall be calculated as set forth on the attached and further
explained as follows:

1.   The heat pump units  serving the leased  premises  shall be  identified  by
     model number.

2.   The  actual  heat pump  operating  hours  will be  recorded  for each month
     (column 3) and multiplied by the energy use factor (column 4) applicable to
     the heat pump model to establish the total energy units (column 5).

3.   The  total  energy  units  for all heat  pumps is then  added to the  total
     auxiliary  usage to establish  the grand total usage and energy cost (total
     KWH) for the building.

4.   The  grand  total  usage  and  energy  cost is  multiplied  by the  utility
     company's rate per KWH to establish the total cost for kilowatt hours.

5.   The total KWH are  divided  by the total  heat pump  usage and  charges  to
     establish the heat pump hourly rate (column 6).

6.   The monthly  tenant  charge is the heat pump hourly rate  multiplied by the
     total energy units (column 5).

7.   Tenant  will  also pay  18.13%  and  5.12%  of  general  usage/common  area
     electric.
<PAGE>

                                 ADDITIONAL RENT

                      Real Estate and Insurance Escalation

In  addition  to the  rents  set  forth in the  Lease,  and  heretofore  in this
Schedule, with 1995 as the base year, Tenant shall pay 23.25% of the increase in
real  estate  taxes and other  government  levies in lieu of taxes  (payable  in
October of the  following  year),  and 23.25% of the  increase in  property  and
liability insurance premiums (payable in February of the following year).





</TEXT>
</DOCUMENT>
