BIORELIANCE CORP
SIXTH REPLACEMENT REVOLVING PROMISSORY NOTE
<DOCUMENT>
<TYPE>EX-10.18
<SEQUENCE>9
<FILENAME>w58573ex10-18.htm
<DESCRIPTION>SIXTH REPLACEMENT REVOLVING PROMISSORY NOTE
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<P align="right"><FONT size="2"><B>EXHIBIT 10.18</B>
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<P align="center"><FONT size="2"><B>SIXTH REPLACEMENT REVOLVING PROMISSORY NOTE</B>
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        <TD valign="top"><FONT size="2">$2,000,000</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
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Rockville, Maryland</FONT></TD>
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As of October&nbsp;1, 2001</FONT></TD>
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<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>FOR VALUE RECEIVED</B>, BIORELIANCE CORPORATION, a corporation organized and
in good standing under the laws of the State of Delaware, successor in interest
to Microbiological Associates, Inc. (the &#147;Company&#148;), BIORELIANCE TESTING AND
DEVELOPMENT, LLC, a limited liability company organized and in good standing
under the laws of the State of Delaware (&#147;BT&#038;D LLC&#148;), BIORELIANCE
MANUFACTURING, LLC, a limited liability company organized and in good standing
under the laws of the State of Delaware (&#147;BMF LLC&#148;) and BIORELIANCE VIRAL
MANUFACTURING, INC. (formerly known as Magenta Viral Production, Inc.),
successor in interest to BioReliance Testing and Development, Inc. and
BioReliance Manufacturing, Inc., a corporation organized and in good standing
under the laws of the State of Delaware (&#147;Viral Manufacturing;&#148; together with
the Company, BT&#038;D LLC, and BMF LLC, each a &#147;Borrower&#148; and collectively, the
&#147;Borrowers&#148;), jointly and severally, promise to pay to the order of BANK OF
AMERICA, N.A., successor to NATIONSBANK, N.A., each a national banking
association, its successors and assigns (the &#147;Lender&#148;), the principal sum of
TWO MILLION DOLLARS ($2,000,000) (the &#147;Principal Sum&#148;), or so much thereof as
has been or may be advanced or readvanced to or for the account of the
Borrowers pursuant to the terms and conditions of the Loan Agreement (as
hereinafter defined), together with interest thereon at the rate or rates
hereinafter provided, in accordance with the following:
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<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Interest</B>. Commencing as of the date hereof and continuing until
repayment in full of all sums due hereunder, the unpaid Principal Sum shall
bear interest at the LIBOR Rate (as hereinafter defined), plus the applicable
LIBOR Rate Additional Percentage (the &#147;LIBOR Rate Option&#148;).
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;&nbsp; For purposes hereof, the &#147;LIBOR Rate Additional Percentage&#148; shall mean
the percentages applicable to this Note in accordance with the following:
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        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If the ratio of Funded Debt divided by EBITDA is equal to or
greater than 2.75 to 1.0, the LIBOR Rate Additional Percentage shall be
two and three quarters percent (2.75%);</FONT></TD>
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        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If the ratio of Funded Debt divided by EBITDA is less than 2.75
to 1.0, but equal to or greater than 2.0 to 1.0, the LIBOR Rate
Additional Percentage shall be one and three quarters percent (1.75%);</FONT></TD>
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        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If the ratio of Funded Debt divided by EBITDA is less than 2.0
to 1.0, but equal to or greater than 1.25 to 1.0 the LIBOR Rate
Additional Percentage shall be one and one quarter percent (1.25%); and</FONT></TD>
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        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If the ratio of Funded Debt divided by EBITDA is less than 1.25
to 1.0, the LIBOR Rate Additional Percentage shall be .85/100&nbsp;percent
(0.85%)</FONT></TD>
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<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&nbsp;&nbsp; The initial LIBOR Rate Additional Percentage shall be one and one
quarter percent (1.25%). Thereafter, the applicable LIBOR Rate Additional
Percentage for all Advances shall be calculated and adjusted quarterly, based
on the quarterly financial statements of the Borrowers required to be submitted
to the Lender pursuant to Section&nbsp;5.1(c) of the Loan
Agreement, commencing with the statements for the quarter ending December
31, 2001. Such
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<P><FONT size="2">quarterly changes shall be effective commencing five (5)
Banking Days after submission by the Borrowers of the required financial
statements; it being understood, however, that, subject to the provisions of
the immediately following sentence, in the event the quarterly financial
statements are not submitted when due, the LIBOR Rate Additional Percentage
shall be two percent (2.00%), until such financial statements are submitted as
required, at which time, the LIBOR Rate Additional Percentage (for the balance
of the quarterly period) shall be determined as set forth above. If such
financial statements are not submitted when due, but are received within thirty
(30)&nbsp;days of when due, the Lender will return to the Borrower any additional
interest collected in excess of the amount that should have otherwise been due
hereunder based on the financial statements. For purposes of this Note,
&#147;Funded Debt&#148; and &#147;EBITDA&#148; shall each be determined based on the consolidated
quarterly financial statements of the Borrowers and shall have the meanings set
forth in the Loan Agreement.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;&nbsp;&nbsp;&nbsp; For purposes hereof, the &#147;LIBOR Rate&#148; shall mean a fluctuating rate of
interest equal to the one month rate of interest (rounded upwards, if necessary
to the nearest 1/100 of 1%) appearing on Telerate Page 3750 (or any successor
page) as the one month London interbank offered rate for deposits in Dollars at
approximately 11:00&nbsp;a.m. (London time) on the second preceding business day as
adjusted from time to time in Lender&#146;s sole discretion for then applicable
reserve requirements, deposit insurance assessment rates and other regulatory
costs. If for any reason such rate is not available, the term &#147;LIBOR Rate&#148;
shall mean the fluctuating rate of interest equal to the one month rate of
interest (rounded upwards, if necessary to the
nearest 1/100 of 1%) appearing on Reuters Screen LIBO Page as the one
month London interbank offered rate for deposits in Dollars at approximately
11:00&nbsp;a.m. (London time) on the
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<P><FONT size="2">second preceding business day, as adjusted from
time to time in Lender&#146;s sole discretion for then applicable reserve
requirements, deposit insurance assessment rates and other regulatory costs;
provided, however, if more than one rate is specified on Reuters Screen LIBO
page, the applicable rate shall be the arithmetic mean of all such rates.
&#147;Telerate Page 3750&#148; means the British Bankers Association Libor Rates
(determined as of 11:00&nbsp;a.m. London time) that are published by Dow Jones
Telerate, Inc.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;&nbsp;&nbsp;&nbsp; The Borrowers shall pay to the Lender, as additional interest, the
following sums, at the time and in the manner hereinafter set forth:
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A)&nbsp;&nbsp;&nbsp; if, due to either: (i)&nbsp;the introduction of or any change (including,
without limitation, any change by way of imposition or increase of reserve
requirements) in or in the interpretation of any law or regulation or (ii)&nbsp;the
compliance by the Lender with any guideline or request from any central bank or
other governmental authority (whether or not having the force of law), there
shall be any increase in the cost to the Lender of agreeing to make or making,
funding or maintaining advances of all or a portion of the Principal Sum, then
the Borrowers shall from time to time, upon demand by the Lender, pay to the
Lender additional amounts to indemnify the Lender against any such increased
costs. A certificate as to the amount of such increased costs submitted to the
Borrowers by the Lender shall in the absence of manifest error be conclusive.
It shall be deemed, for purposes of computing any increased costs pursuant to
this Section, that (i)&nbsp;the making and maintaining of advances of the Principal
Sum which accrue interest based on the LIBOR Rate have been made by the
Lender from its office in London, England and (ii)&nbsp;the funding of each Advance
of the Principal Sum by the Lender which accrues interest based on the LIBOR
Rate has been made through the London
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<P><FONT size="2">Interbank Market. Such additional cost
shall be payable hereunder at the time and in the manner that interest is
payable hereunder for such costs incurred since the last interest payment;
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<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B)&nbsp;&nbsp;&nbsp; the Borrowers shall also pay to the Lender at the time and in the
manner that interest is payable hereunder for each advance, the cost since the
last interest payment date, as determined in good faith by the Lender, of
complying, in connection with such advance during such interest period, with
any reserve, special deposit or similar requirement (including but not limited
to reserve requirements under Federal Reserve Regulation&nbsp;D) imposed or deemed
applicable against any assets held by or deposits or accounts in or with or
credit extended by the Lender, or the office of the Lender in London, England,
by any United States governmental authority charged with the administration of
such requirements. Each notification as to the amount of such cost, delivered
to the Borrowers by the Lender shall, in the absence of manifest error, be
conclusive as to the amount of such cost. It shall be deemed for purposes of
computing cost pursuant to the above provision that the making and maintaining
of each advance which accrues interest based on the LIBOR Rate has been made by
the Lender through its office in London, England.
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<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;&nbsp;&nbsp;&nbsp; In respect to any interest rate election hereunder and any
transactions contemplated hereby, the Borrowers authorize the Lender to accept,
rely upon, act upon and comply with, any verbal or written instructions,
requests, confirmations and orders of Capers W.
McDonald, President and CEO, or John Coker, CFO, or their successors in
office, on behalf of the Borrowers. The Borrowers acknowledge and agree that
the transmission between the Borrowers and the Lender of any such instructions,
requests, confirmations and orders involves the possibility of errors,
omissions, mistakes and discrepancies and agrees to adopt such internal
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<P><FONT size="2">
measures and operational procedures to protect its interests. By reason
thereof, the Borrowers hereby assume all risk of loss and responsibility for,
releases and discharges the Lender from any and all responsibility or liability
for, and agrees to indemnify, reimburse on demand and hold the Lender harmless
from, any and all claims, actions, damages, losses, liability and expenses by
reason of, arising out of or in any way connected with or related to, (i)&nbsp;the
Lender&#146;s acceptance, reliance and actions upon, compliance with or observation
of any such instructions, requests, confirmations or orders, and (ii)&nbsp;any such
errors, omissions, mistakes and discrepancies, except those caused by the
Lender&#146;s gross negligence or willful misconduct.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;&nbsp;&nbsp;&nbsp; All interest payable under the terms of this Note shall be calculated
on the basis of a 360-day year and the actual number of days elapsed.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Payments and Maturity</B>. The unpaid Principal Sum, together with
interest thereon at the rate or rates provided above, shall be payable as
follows:
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;&nbsp; Interest only on the unpaid Principal Sum shall be due and payable
monthly, commencing October&nbsp;31, 2001 and on the last day of each month
thereafter to maturity; and
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&nbsp;&nbsp; Unless sooner paid, the unpaid Principal Sum, together with interest
accrued and unpaid thereon, shall be due and payable in full on May&nbsp;31, 2003.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The fact that the balance hereunder may be reduced to zero from time to
time pursuant to the Loan Agreement will not affect the continuing validity of
this Note or the Loan Agreement, and the balance may be increased to the
Principal Sum after any such reduction to zero.
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<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Default Interest</B>. Upon the occurrence of an Event of Default (as
hereinafter defined), the unpaid Principal Sum shall bear interest thereafter
at a rate five percent (5.0%) per annum in excess of the LIBOR Rate until such
Event of Default is cured.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Late Charges</B>. If the Borrowers shall fail to make any payment under
the terms of this Note within fifteen (15)&nbsp;days after the date such payment is
due, the Borrowers shall pay to the Lender on demand a late charge equal to
three percent (3%) of such payment.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Application and Place of Payments</B>. All payments, made on account of
this Note shall be applied first to the payment of any late charge then due
hereunder, second to the payment of accrued and unpaid interest then due
hereunder, and the remainder, if any, shall be applied to the unpaid Principal
Sum. All payments on account of this Note shall be paid in lawful money of the
United States of America in immediately available funds during regular business
hours of the Lender at its principal office in Rockville, Maryland or at such
other times and places as the Lender may at any time and from time to time
designate in writing to the Borrowers.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Loan Agreement and Other Loan Documents</B>. This Note is the &#147;Second
Restated Note&#148; described in that certain Fourth Amendment to Amended and
Restated Replacement Loan Agreement of even date herewith by and among the
Borrowers and the Lender, which amends that certain Amended and Restated
Replacement Loan Agreement dated
October&nbsp;31, 1997 by and among the Borrowers and the Lender (the Amended
and Restated Replacement Loan Agreement, as thereafter amended from time to
time, is hereinafter called the &#147;Loan Agreement&#148;). This Note amends and
restates in its entirety that certain Fifth Replacement Revolving Promissory
Note dated as of May&nbsp;31, 2001 in the maximum principal amount of Two
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<P><FONT size="2">Million
Dollars ($2,000,000) from the Borrowers in favor of the Lender (as amended from
time to time, the &#147;Replacement Note&#148;). It is expressly agreed that the
indebtedness evidenced by the Replacement Note has not been extinguished or
discharged hereby. The Borrowers agree that the execution of this Agreement is
not intended to and shall not cause or result in a novation with respect to the
Replacement Note. The indebtedness evidenced by this Note is included within
the meaning of the term &#147;Obligations&#148; as defined in the Loan Agreement. The
term &#147;Loan Documents&#148; as used in this Note shall mean collectively this Note,
the Loan Agreement and any other instrument, agreement, or document previously,
simultaneously, or hereafter executed and delivered by the Borrowers and/or any
other person, singularly or jointly with any other person, evidencing,
securing, guaranteeing, or in connection with the Principal Sum, this Note
and/or the Loan Agreement. All capitalized terms used herein and not otherwise
defined shall have the meanings given to such terms in the Loan Agreement.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7. <B>Additional Parties; Assumption</B>. BT&#038;D LLC and BMF LLC agree (i)&nbsp;to
become joint and several co-makers of this Note; (ii)&nbsp;to be bound by all the
terms and conditions of this Note; (iii)&nbsp;to assume and agree to pay and perform
when due all present and future indebtedness, liabilities and obligations of a
Borrower under, based upon, or arising out of the Loan Documents and
instruments and agreements relating thereto; and (iv)&nbsp;to honor, perform and
comply with, in all respects, all terms and provisions of all of the Loan
Documents. All references in the Loan Documents to &#147;Borrower&#148; shall be deemed
to refer to BT&#038;D LLC and BMF LLC. Furthermore, all present and future
obligations of the Borrowers under the Loan Documents shall be deemed to refer
to all present and future obligations of BT&#038;D LLC and BMF LLC.
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<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Events of Default</B>. The occurrence of any one or more of the following
events shall constitute an event of default (individually, an &#147;Event of
Default&#148; and collectively, the &#147;Events of Default&#148;) under the terms of this
Note:
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;&nbsp; The failure of the Borrowers to pay to the Lender when due any and all
amounts payable by the Borrowers to the Lender and such failure remains uncured
for five (5)&nbsp;days after written notice thereof; or
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&nbsp;&nbsp; The occurrence of an event of default (as defined therein) under the
terms and conditions of any of the other Loan Documents.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Remedies</B>. Upon the occurrence of an Event of Default, at the option of
the Lender, all amounts payable by the Borrowers to the Lender under the terms
of this Note shall immediately become due and payable by the Borrowers to the
Lender without notice to the Borrowers or any other person, and the Lender
shall have all of the rights, powers, and remedies available under the terms of
this Note, any of the other Loan Documents and all applicable laws. The
Borrowers and all endorsers, guarantors, and other parties who may now or in
the future be primarily or secondarily liable for the payment of the
indebtedness evidenced by this Note hereby severally waive presentment, protest
and demand, notice of protest, notice of demand and of dishonor and non-payment
of this Note and expressly agree that this Note or any payment
hereunder may be extended from time to time without in any way affecting
the liability of the Borrowers, guarantors and endorsers.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Until such time as the Lender is not committed to extend further credit to
the Borrowers and all Obligations of the Borrowers to the Lender have been
indefeasibly paid in full in cash, and subject to and not in limitation of the
provisions set forth in the next following paragraph
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<P><FONT size="2">below, no Borrower shall
have any right of subrogation (whether contractual, arising under the
Bankruptcy Code or otherwise), reimbursement or contribution from any Borrower
or any guarantor, nor any right of recourse to its security for any of the
debts and obligations of any Borrower which are the subject of this Note.
Except as otherwise expressly permitted by the Loan Agreement, any and all
present and future debts and obligations of any Borrower to any other Borrower
are hereby subordinated to the full payment and performance of all present and
future debts and obligations to the Lender under this Note and the Loan
Agreement and the Loan Documents, provided, however, notwithstanding anything
set forth in this Note to the contrary, prior to the occurrence of a payment
Default, the Borrowers shall be permitted to make payments on account of any of
such present and future debts and obligations from time to time in accordance
with the terms thereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each Borrower further agrees that, if any payment made by any Borrower or
any other person is applied to this Note and is at any time annulled, set
aside, rescinded, invalidated, declared to be fraudulent or preferential or
otherwise required to be refunded or repaid, or the proceeds of any property
hereafter securing this Note is required to be returned by the Lender to any
Borrower, its estate, trustee, receiver or any other party, including, without
limitation, such
Borrower, under any bankruptcy law, state or federal law, common law or
equitable cause, then, to the extent of such payment or repayment, such
Borrower&#146;s liability hereunder (and any lien, security interest or other
collateral securing such liability) shall be and remain in full force and
effect, as fully as if such payment had never been made, or, if prior thereto
any such lien, security interest or other collateral hereafter securing such
Borrower&#146;s liability hereunder shall have been released or terminated by virtue
of such cancellation or surrender, this Note (and such
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<P><FONT size="2">lien, security interest
or other collateral) shall be reinstated in full force and effect, and such
prior cancellation or surrender shall not diminish, release, discharge, impair
or otherwise affect the obligations of such Borrower in respect of the amount
of such payment (or any lien, security interest or other collateral securing
such obligation).
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The JOINT AND SEVERAL obligations of each Borrower under this Note shall
be absolute, irrevocable and unconditional and shall remain in full force and
effect until the outstanding principal of and interest on this Note and all
other Obligations or amounts due hereunder and under the Loan Agreement and the
Loan Documents shall have been indefeasibly paid in full in cash in accordance
with the terms thereof and this Note shall have been canceled.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Expenses</B>. The Borrowers, jointly and severally, promise to pay to the
Lender on demand by the Lender all reasonable costs and expenses incurred by
the Lender in connection with the collection and enforcement of this Note,
including, without limitation, reasonable attorneys&#146; fees and expenses and all
court costs.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Notices</B>. Any notice, request, or demand to or upon the Borrowers or
the Lender shall be deemed to have been properly given or made when delivered
in accordance with Section&nbsp;9.1 of the Loan Agreement.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Miscellaneous</B>. Each right, power, and remedy of the Lender as
provided for in this Note or any of the other Loan Documents, or now or
hereafter existing under any applicable law or otherwise shall be cumulative
and concurrent and shall be in addition to every other right, power, or remedy
provided for in this Note or any of the other Loan Documents or now or
hereafter existing under any applicable law, and the exercise or beginning of
the exercise by the Lender of any one or more of such rights, powers, or
remedies shall not preclude the
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<P><FONT size="2">simultaneous or later exercise by the Lender of
any or all such other rights, powers, or remedies. No failure or delay by the
Lender to insist upon the strict performance of any term, condition, covenant,
or agreement of this Note or any of the other Loan Documents, or to exercise
any right, power, or remedy consequent upon a breach thereof, shall constitute
a waiver of any such term, condition, covenant, or agreement or of any such
breach, or preclude the Lender from exercising any such right, power, or remedy
at a later time or times. By accepting payment after the due date of any
amount payable under the terms of this Note, the Lender shall not be deemed to
waive the right either to require prompt payment when due of all other amounts
payable under the terms of this Note or to declare an Event of Default for the
failure to effect such prompt payment of any such other amount. No course of
dealing or conduct shall be effective to amend, modify, waive, release, or
change any provisions of this Note.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Partial Invalidity</B>. In the event any provision of this Note (or any
part of any provision) is held by a court of competent jurisdiction to be
invalid, illegal, or unenforceable in any respect, such invalidity, illegality,
or unenforceability shall not affect any other provision (or remaining part of
the affected provision) of this Note; but this Note shall be construed as if
such invalid, illegal, or unenforceable provision (or part thereof) had not
been contained in this Note, but only to the extent it is invalid, illegal, or
unenforceable.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;14.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Captions</B>. The captions herein set forth are for convenience only and
shall not be deemed to define, limit, or describe the scope or intent of this
Note.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <B>Applicable Law</B>. Each of the Borrowers acknowledges and agrees that
this Note shall be governed by the laws of the State of Maryland, even though
for the convenience and at the request of the Borrowers, this Note may be
executed elsewhere.
</FONT>
<P align="center"><FONT size="2">12</FONT>
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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;16.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>ARBITRATION</B>. ANY CONTROVERSY OR CLAIM BETWEEN OR AMONG THE PARTIES
HERETO INCLUDING BUT NOT LIMITED TO THOSE ARISING OUT OF THIS NOTE, THE LOAN
DOCUMENTS OR ANY RELATED INSTRUMENTS, AGREEMENTS OR DOCUMENTS, INCLUDING ANY
CLAIM BASED ON OR ARISING FROM AN ALLEGED TORT, SHALL BE DETERMINED BY BINDING
ARBITRATION IN ACCORDANCE WITH THE FEDERAL ARBITRATION ACT (OR IF NOT
APPLICABLE, THE APPLICABLE STATE LAW), THE RULES OF PRACTICE AND PROCEDURE FOR
ARBITRATION OF COMMERCIAL DISPUTES OF ENDISPUTE, INC., D/B/A J.A.M.S./ENDISPUTE
(&#147;J.A.M.S.&#148;) AND THE &#147;SPECIAL RULES&#148; SET FORTH BELOW. IN THE EVENT OF AN
INCONSISTENCY, THE SPECIAL RULES SHALL CONTROL.
JUDGMENT UPON ANY ARBITRATION AWARD MAY BE ENTERED IN ANY COURT HAVING
JURISDICTION. ANY PARTY TO THIS NOTE, AGREEMENT OR DOCUMENT MAY BRING ANY
ACTION, INCLUDING A SUMMARY OR EXPEDITED PROCEEDING, TO COMPEL ARBITRATION OF
ANY CONTROVERSY OR CLAIM TO WHICH THIS NOTE, AGREEMENT OR DOCUMENT RELATES IN
ANY COURT HAVING JURISDICTION OVER SUCH ACTION.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A)&nbsp;&nbsp;&nbsp; SPECIAL RULES. THE ARBITRATION SHALL BE CONDUCTED IN MONTGOMERY
COUNTY, MARYLAND AND ADMINISTERED BY J.A.M.S. WHO WILL APPOINT AN ARBITRATOR.
IF J.A.M.S. IS UNABLE OR LEGALLY PRECLUDED FROM ADMINISTERING THE ARBITRATION,
THEN THE AMERICAN ARBITRATION ASSOCIATION WILL SERVE. ALL ARBITRATION HEARINGS
WILL BE COMMENCED WITHIN NINETY (90)&nbsp;DAYS OF THE DEMAND FOR ARBITRATION;
FURTHER, THE
</FONT>
<P align="center"><FONT size="2">13</FONT>
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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<P><FONT size="2">ARBITRATOR SHALL ONLY, UPON A SHOWING OF CAUSE, BE PERMITTED TO
EXTEND THE COMMENCING OF SUCH HEARING FOR AN ADDITIONAL SIXTY (60)&nbsp;DAYS.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B)&nbsp;&nbsp;&nbsp; RESERVATION OF RIGHTS. NOTHING IN THIS NOTE, AGREEMENT OR DOCUMENT
SHALL BE DEEMED TO: (I)&nbsp;LIMIT THE APPLICABILITY OF ANY OTHERWISE APPLICABLE
STATUTES OF LIMITATION OR REPOSE AND ANY WAIVERS CONTAINED IN THIS NOTE,
AGREEMENT OR DOCUMENT; OR (II)&nbsp;BE A WAIVER BY THE LENDER OF THE PROTECTION
AFFORDED TO IT BY 12 U.S.C. &#167;91 OR ANY SUBSTANTIALLY EQUIVALENT STATE LAW; OR
(III)&nbsp;LIMIT THE RIGHT OF
THE LENDER: (A)&nbsp;TO EXERCISE SELF HELP REMEDIES ( BUT NOT INCLUDING
SETOFF), OR (B)&nbsp;TO FORECLOSE AGAINST ANY REAL OR PERSONAL PROPERTY COLLATERAL,
OR (C)&nbsp;TO OBTAIN FROM A COURT PROVISIONAL OR ANCILLARY REMEDIES SUCH AS (BUT
NOT LIMITED TO) INJUNCTIVE RELIEF, WRIT OF POSSESSION OR THE APPOINTMENT OF A
RECEIVER. THE LENDER MAY EXERCISE SUCH SELF HELP RIGHTS, FORECLOSE UPON SUCH
PROPERTY, OR OBTAIN SUCH PROVISIONAL OR ANCILLARY REMEDIES BEFORE, DURING OR
AFTER THE PENDENCY OF ANY ARBITRATION PROCEEDING BROUGHT PURSUANT TO THIS NOTE,
AGREEMENT OR DOCUMENT. NEITHER THE EXERCISE OF SELF HELP REMEDIES NOR THE
INSTITUTION OR MAINTENANCE OF ANY ACTION FOR FORECLOSURE OR FOR PROVISIONAL OR
ANCILLARY REMEDIES SHALL CONSTITUTE A WAIVER OF THE RIGHT OF ANY PARTY,
INCLUDING THE
</FONT>
<P align="center"><FONT size="2">14</FONT>
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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<P><FONT size="2">CLAIMANT IN SUCH ACTION, TO ARBITRATE THE MERITS OF THE
CONTROVERSY OR CLAIM OCCASIONING RESORT TO SUCH REMEDIES.
</FONT>
<P align="center"><FONT size="2">&#091;SIGNATURES BEGIN ON THE FOLLOWING PAGE&#093;
</FONT>
<P align="center"><FONT size="2">15</FONT>
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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IN WITNESS WHEREOF, the Borrowers have caused this Note to be executed
under seal by their duly authorized officers as of the date first written
above.
</FONT>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="45%">&nbsp;</TD>
        <TD width="15%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="14%">&nbsp;</TD>
        <TD width="20%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top" nowrap><FONT size="2">WITNESS/ATTEST:</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="4" nowrap align="left" valign="top"><FONT size="2">
BIORELIANCE CORPORATION</FONT></TD>
</TR>

<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ Evdoxia E. Kopsidas</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">By:&nbsp;</FONT></TD>
        <TD align="left" colspan="2" nowrap valign="top"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
        &nbsp;&nbsp;&nbsp;/s/ John L. Coker</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">(SEAL)</FONT></TD>

<TR>
        <TD valign="top"><HR size="1" noshade></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" colspan="2" valign="top"><FONT size="2">
<HR size="1" noshade></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Name:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
        <TD colspan="2" align="left" valign="top"><FONT size="2">John L. Coker</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Title:&nbsp;</FONT></TD>
        <TD align="left" colspan="2" valign="top"><FONT size="2">Vice President&#151; Finance and
Administration, Chief Financial
Officer</FONT></TD>
</TR>


<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top" nowrap><FONT size="2">WITNESS/ATTEST:</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="4" nowrap align="left" valign="top"><FONT size="2">
BIORELIANCE TESTING AND
DEVELOPMENT, LLC</FONT></TD>
</TR>

<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ Evdoxia E. Kopsidas</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">By:&nbsp;</FONT></TD>
        <TD align="left" colspan="2" nowrap valign="top"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
        &nbsp;&nbsp;&nbsp;/s/ John L. Coker</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">(SEAL)</FONT></TD>

<TR>
        <TD valign="top"><HR size="1" noshade></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" colspan="2" valign="top"><FONT size="2">
<HR size="1" noshade></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Name:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
        <TD colspan="2" align="left" valign="top"><FONT size="2">John L. Coker</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Title:&nbsp;</FONT></TD>
        <TD align="left" colspan="2" valign="top"><FONT size="2">Vice President&#151; Finance and
Administration, Chief Financial
Officer</FONT></TD>
</TR>

<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top" nowrap><FONT size="2">WITNESS/ATTEST:</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="4" nowrap align="left" valign="top"><FONT size="2">
BIORELIANCE MANUFACTURING, LLC
</FONT></TD>
</TR>

<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ Evdoxia E. Kopsidas</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">By:&nbsp;</FONT></TD>
        <TD align="left" colspan="2" nowrap valign="top"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
        &nbsp;&nbsp;&nbsp;/s/ John L. Coker</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">(SEAL)</FONT></TD>

<TR>
        <TD valign="top"><HR size="1" noshade></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" colspan="2" valign="top"><FONT size="2">
<HR size="1" noshade></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Name:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
        <TD colspan="2" align="left" valign="top"><FONT size="2">John L. Coker</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Title:&nbsp;</FONT></TD>
        <TD align="left" colspan="2" valign="top"><FONT size="2">Vice President&#151; Finance and
Administration, Chief Financial
Officer</FONT></TD>
</TR>



<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top" nowrap><FONT size="2">WITNESS/ATTEST:</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="4" nowrap align="left" valign="top"><FONT size="2">
BIORELIANCE VIRAL MANUFACTURING, INC.
</FONT></TD>
</TR>

<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ Evdoxia E. Kopsidas</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">By:&nbsp;</FONT></TD>
        <TD align="left" colspan="2" nowrap valign="top"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
        &nbsp;&nbsp;&nbsp;/s/ John L. Coker</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">(SEAL)</FONT></TD>

<TR>
        <TD valign="top"><HR size="1" noshade></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" colspan="2" valign="top"><FONT size="2">
<HR size="1" noshade></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Name:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
        <TD colspan="2" align="left" valign="top"><FONT size="2">John L. Coker</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Title:&nbsp;</FONT></TD>
        <TD align="left" colspan="2" valign="top"><FONT size="2">Vice President&#151; Finance and
Administration, Chief Financial
Officer</FONT></TD>
</TR>
</TABLE>
</CENTER>

<P align="center"><FONT size="2">16</FONT>




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