a 28-year - old man working in a local factory was admitted to the department of medicine with the diagnosis of acute dengue infection from where he was referred to the psychiatry outpatient department of the university college of medical sciences and associated guru tegh bahadur hospital with the complaint of altered behavior . there was reported history of talking more than usual , feeling happy , increased activity , increased self - confidence , decreased need for sleep , and food , irritability , outbursts of aggression with grandiosity for a period of 5 days . three days prior to onset of psychiatric illness , he developed fever ( 40.6c ) associated with severe headache , transient spells of altered consciousness , generalized body ache , anorexia , and occasional vomiting . there was no history of neck rigidity , photophobia , seizure , and covert or overt bleeding . general and systemic examinations were unremarkable . the patient 's blood pressure and pulse rate were 114/76 mm hg and 110 - 120 per minute respectively . his igm elisa for dengue was positive ; other investigations revealed a platelet count of 26,000/l , total leukocyte count : 5400/cmm with lymphocytes 46% . blood electrolytes , blood sugar , lipid profile , and renal function tests were within normal range . liver function tests were also normal except for aspartate transaminase ( 258 iu / ml ) and alanine transaminase ( 366 iu / ml ) . the patient received three units of platelet concentrates transfusion and was kept under observation and received only supportive therapy . on the third day of dengue fever , the patient exhibited discernable symptoms ( mentioned above ) of a manic episode . mental status examination revealed a young man of average built , wearing bright yellow colored shirt and green trousers with a pink hat with a string of beads round his neck . he continued to move about in the examination room chanting some mantras and in between making claims of possessing special superhuman abilities like ability to engulf the sun , to trap the air , so on and so forth . no amount of explanation could shake him off his grandiose delusions rather it increased his irritability . mini mental state examination revealed no cognitive impairment with score of 28/30 . computed tomography scan of the head he was started on tablet divalproex sodium 1500 mg / day and risperidone 6 mg / day to which he responded successfully within 3 weeks . subsequent blood investigations conducted on day 18 of admission were within normal limits and he was followed up in the outpatient department of psychiatry for 3 months and did not develop the symptoms of mania . the case illustrates a clear temporal relationship between the onset of dengue fever and the emergence of manic symptoms . in addition to this , the patient 's past and family history was found to be unremarkable for any episode of a distinct mood disorder or cyclothymia . in view of the above - mentioned facts , a possible organic etiology ( dengue infection ) for the manic episode was entertained . to the best of our knowledge , there was one previous report of mania in association with dengue infection . our case illustrates an earlier emergence of discernible manic symptoms ( on the third day of dengue fever ) in contrast to the earlier report of manic symptoms appearing on the sixth day of dengue fever . a systematic study is needed to find out the prevalence and pattern of associated psychiatry disorders , as dengue is a major health problem in some parts of asia .
dengue fever , also known as break bone fever , is a mosquito - borne infection that causes a severe flu - like illness . during the last few years , there had been increasing reports of dengue fever with unusual manifestations , primarily with neurological symptoms . 
 psychiatric morbidity during acute dengue infection has rarely been reported . 
 there has not been any systemic study mentioning the prevalence and pattern of psychiatric sequelae . 
 we report a 28-year - old male who after an acute dengue infection developed an episode of mania which was successfully treated .