adrenal gland cysts and pseudocysts are rare lesions and usually are asymptomatic , but may cause many diagnostic and management difficulties . they are mostly occurring in the 4 and 5 decades of life with female predominance . the majority of adrenal cysts is asymptomatic and is accidentally discovered in autopsy or during the radiologic studies such as ultrasonography , ct scan or mri performed for other causes . cysts with larger size may cause compressive effect on neighboring organs , or cause abdominal symptoms such as flunk pain , nausea and vomiting . large size adrenal cysts may rupture spontaneously or after blunt abdominal trauma resulting in massive hemorrhage and retroperitoneal hematoma , which can presents with acute abdomen and hypovolemic shock , and imitate acute abdomen . reported a case of 28-year - old women presented with acute abdomen and hypovolemic shock due to hemorrhagic pseudocyst of left adrenal gland , and was treated successfully with left adrenalectomy . they suggested that high estrogen levels during pregnancy may cause rapid growth of adrenal cystic lesions and relaxation of cyst wall connective tissue . some other authors reported similar cases of large size adrenal cysts that presented with massive hemorrhage and acute abdomen following spontaneously or traumatic rupture in nonpregnant females . herein , we report a case of a young female with spontaneously ruptured large size right adrenal pseudocyst manifested with sudden onset abdominal pain , retroperitoneal hematoma and hemorrhagic shock that was resulted in surgical emergency . a 21-year - old female presented with right side flunk pain over the 12 hours prior to admission . severe abdominal pain she could nt walk from few hours prior to the admission , and was , therefore , brought by her roommates to the emergency department . after initial resuscitation and stabilization with intravenous fluids , an abdominal ultrasonography was done in emergency room , which showed a giant cystic and solid mass measured 1515 cm with some free fluid in abdominal cavity and large retroperitoneal hematoma ( figure 1 ) . there was approximately 500 milliliter blood and clots , and a large retroperitoneal hematoma in the right side of abdominal cavity adjacent to renal lodge . exploration of retroperitoneal hematoma revealed a large cyst with active bleeding in the right adrenal gland . the post operative phase of the patient was uneventful , and she was discharged with a satisfactory condition on 11 day after the surgery . the macroscopic pathologic study showed that the gross appearance of right adrenal mass consisted of a piece of gray - brown membranous tissue with peripheral fat measuring 71.50.5 cm . the histopathologic finding included a thick fibrous capsule without prominent epithelial cells in most areas , a wall containing some normal adrenal cortex tissue , the center of the cavity containing hemorrhage , and foamy macrophages compatible with adrenal pseudocyst ( figure 2 ) . the patients did not complain during the follow ups until one year after the operation . abdominal ultrasonography showing a large cystic and solid mass in right adrenal lodge with retroperitoneal hematoma and some free fluid in abdominal cavity adrenal tissue with fibrotic wall without prominent epithelial cells in most areas , containing hemorrhage and foamy macrophages ( hematoxylin and eosin staining , original magnification x100 ) in previous post - mortem studies the incidence of adrenal cysts was estimated between 0.06% and 0.18% in autopsies . pseudocysts which are originated from adrenal medulla or cortex are surrounded by a fibrous capsule which separates the cyst from the normal adrenal tissue . the exact etiology of pseudocyst formation is not clear , but they might be formed secondary to cystic degeneration of a primary or vascular adrenal tumors , or following trauma or infection . it is also suggested that pseudocysts may develop as a result of loss of cellular coverage of true cystic lesions following inflammation and hemorrhage . however , it is possible to conservatively monitor small asymptomatic and nonfunctional lesions with repeated imaging studies . surgery is recommended for symptomatic and functional cysts as well as those with sizes larger than five cm , which increases the risk of rupture and hemorrhage , or with suspicious characteristics that increases the risk of malignant lesion or complicated cystic lesions . although recently some of surgeons choose the percutaneous drainage approach in the management of adrenal cysts , this approach can not reliably differentiate between benign adrenal cyst and malignant lesions in all cases . moreover , recurrence of the cyst may occur in some of cases , which are treated with fine - needle aspiration . adrenal cystic lesions may enlarge enough and rupture , and become hemorrhagic in the absence of any symptoms observed in a previously healthy adult . the condition may imitate acute abdomen and result in circulatory shock . in some cases , preoperative diagnosis may be difficult , and accurate diagnosis may be postponed till the time of exploratory laparotomy . surgical resection of adrenal cysts and open adrenalectomy are curative and life - saving strategies in the presence of acute adrenal cyst rupture and hemorrhage . emergency physicians and surgeons should consider spontaneously adrenal cyst hemorrhage and rupture in the differential diagnosis of any patient with abdominal symptoms or unexplained hemorrhagic shock . earlier diagnosis and surgical resection of these lesions is curative .
adrenal gland pseudocysts are not common conditions , and most of them are nonfunctional and asymptomatic . 
 however , large pseudocysts may causes abdominal discomfort and have compressive effects on adjacent organs . 
 they may rupture spontaneously or after trauma , and lead to retroperitoneal hemorrhage and surgical emergency . 
 herein , we report a case of 21-year - old female who presented with acute abdomen and hemorrhagic shock due to spontaneous rupture of adrenal pseudocyst . 
 she was treated successfully by open surgery , removal of adrenal pseudocyst and unilateral adrenalectomy .