acute - onset , postoperative endophthalmitis is an uncommon but potentially severe complication of cataract surgery.1 successful treatment of endophthalmitis requires accurate microbiologic diagnosis and prompt treatment with effective antimicrobial agents.2 the endophthalmitis vitrectomy study ( evs ) reported that , for patients with acute - onset , postoperative endophthalmitis and presenting visual acuity of light perception ( lp ) , initial treatment with pars plana vitrectomy ( ppv ) and intravitreal antibiotics was associated with more favorable visual outcomes than was treatment with vitreous tap and intravitreal antibiotics.3 in the evs , ppv was performed within six hours of the initial examination,3 but this may not always be feasible in clinical practice . one alternative approach is to perform prompt vitreous tap and injection of intravitreal antibiotics , followed by ppv as soon as practicable . we present a case of acute - onset , postoperative endophthalmitis managed in this fashion . an 86-year - old male presented five days after uncomplicated phacoemulsification and posterior chamber intraocular lens implantation , with a 24-hour history of progressive visual loss and redness in the operated ( left ) eye . past medical history was significant for hypertension , dyslipidemia , sleep apnea , and essential tremor . slit - lamp examination demonstrated conjunctival injection , corneal edema , and hypopyon ( figure 1 ) . b - scan echography demonstrated vitreous opacification , but no retinal detachment ( figure 2 ) . the patient had presented to a satellite clinic in a suburban location . access to an operating room with ppv equipment and appropriate support staff would not be possible for at least several hours . after a full discussion with the patient , it was decided to perform prompt vitreous tap and injection of intravitreal antibiotics in an attempt to stabilize the eye , followed by ppv as soon as the operating room , vitrectomy equipment , and the appropriate surgical team could be secured . aqueous and vitreous cultures were obtained by needle tap , and the eye was treated with intravitreal injection of vancomycin 1 mg/0.1 ml and ceftazidime 2.25 mg/0.1 ml . approximately four hours after the vitreous tap and invitreal injection of antibiotics , an operating room became available and a 23-gauge ppv was performed . using the vitreous cutter , intraoperative findings included dense vitreous opacification and a superior retinal break located posteriorly near the equator , which was treated with endolaser photocoagulation . there did not appear to be a posterior vitreous detachment ( pvd ) at the time of surgery , and no attempt was made to induce a pvd surgically . vancomycin 1 mg/0.1 ml and ceftazidime 2.25 mg/0.1 ml were re - injected into the vitreous cavity at the conclusion of surgery . postoperatively , the patient was treated with topical moxifloxacin and prednisolone acetate 1% . again , systemic antibiotics were not administered . the vitreous cultures from both the initial needle tap and the subsequent ppv isolated methicillin - resistant staphylococcus epidermidis sensitive to vancomycin . the patient demonstrated clinical improvement and one month later , visual acuity improved to 20/80 . a repeat ppv was performed , at which time epiretinal membranes , but no additional breaks , were identified . the patient was treated with ppv , membrane peeling , inferior retinectomy , and placement of silicone oil . at three months following presentation , visual acuity was 20/200 with silicone oil tamponade . in the evs , 70% of microbiological isolates contained coagulase - negative micrococci.3 in this case , persistent coagulase - negative staphylococci were isolated from the ppv culture four hours following treatment with vancomycin and ceftazidime . antibiotic kill rates are affected by drug concentration as well as contact time with the microorganisms . vancomycin is initially bacteriostatic and then becomes bactericidal after about eight hours.4 the serum killing curves of vancomycin against s. aureus demonstrate a lag phase prior to a rapid killing phase . a single intravitreal injection may not sterilize the vitreous cavity even after several days . in the evs , of the 420 patients enrolled , 33 ( 8% ) were re - cultured within the first week because of clinical signs of worsening infection or inflammation , and of these 33 patients , 14 ( 42% ) were persistently culture - positive . persistent positive cultures were more common in patients randomized to initial needle tap ( 71% ) than those randomized to initial ppv ( 13% ) , and this difference was statistically significant ( p = 0.001).5 although the evs reported an association between ppv and more favorable visual outcomes , ppv is usually performed in an operating room with specialized equipment and support staff . in some circumstances , it may not be feasible to perform ppv within a sufficiently timely fashion , and a staged two - step treatment potentially offers the benefits of faster initiation of antimicrobial therapy . in the evs , among the subset of patients with lp vision treated with ppv , 11% achieved visual acuity of 20/40 or better , 30% achieved visual acuity of 20/100 or better , and 47% developed severe visual loss , defined as visual acuity of worse than 5/200 . therefore , this patient , treated with a staged two - step treatment , achieved a visual outcome consistent with that reported in the evs . the evs reported no significant difference in outcomes with or without the use of systemic amikacin and ceftazidime.3 newer fourth - generation fluoroquinolones , such as gatifloxacin6 and moxifloxacin,7 achieve potentially therapeutic intraocular drug levels in the noninflamed eye . although their benefit in the clinical management of acute - onset , postoperative endophthalmitis remains unproven , systemic fluoroquinolones may be considered in cases similar to this one . systemic gatifloxacin is no longer commercially available in the united states due to associated risks of hyperglycemia and hypoglycemia.8 during the initial ppv , a superior retinal break was identified . this break may have been caused by the endophthalmitis , by the initial vitreous tap and inject , or by the ppv . the eye initially improved to a visual acuity of 20/80 but then developed retinal detachment , which required further surgery . it is possible that the staged two - step treatment may have increased the risk of retinal detachment , although it is also possible that a staged two - step treatment may have improved the final outcome . in the setting of acute - onset , postoperative endophthalmitis with visual acuity of lp and no prompt access to an operating room , a staged two - step treatment ( tap and inject followed by ppv ) may be a reasonable treatment option . it is obviously very difficult to draw definitive conclusions from single cases , and further clinical experience is necessary to validate this report .
a patient presented with acute - onset , postoperative endophthalmitis and visual acuity of light perception . because of a time delay in arranging a pars plana vitrectomy ( ppv ) , the patient was treated with a prompt vitreous tap for culture an injection of vancomycin and ceftazidime . 
 four hours later , the ppv was performed and additional antibiotics were injected . the cultures from both the initial needle tap and the subsequent ppv isolated methicillin - resistant staphylococcus epidermidis sensitive to vancomycin , but resistant to fourth - generation fluoroquinolones . 
 the patient eventually recovered a visual acuity of 20/80 before developing retinal detachment . 
 this case illustrates the time lag necessary to sterilize the vitreous cavity , and suggests a possible two - step staged treatment strategy for situations in which access to ppv equipment and support staff may be limited .