psoriasis is a non - contagious chronic cutaneous inflammatory disease , with a genetic component . while psoriasis can start at any age , there are two peaks of onset : one at around 20 - 30 years old subjects , and the other at subjects of over 50 years of age . ( 1 - 9 ) it is a disease without vital prediction , but with a major impact on life quality and self - value . ( 10 - 14 ) the cells divide every 1.5 days and move rapidly to the surface over 3  4 days , where they are shed in large amounts as incompletely keratinized scales . a special feature of psoriatic lesions is the migration of neutrophils into the involved epidermis . large numbers of cd4 + and cd8 + t cells are found in the epidermis and upper dermis . they appear to play a key role in the development of the cutaneous manifestations of the disease . / th17 mediators , such as ifn- , il2 , il17 , il23 and tnf-. these mediators act on keratinocytes and other cells in the skin , activating them and inducing the formation of lesions . most likely , multiple psoriasis alleles encoded by several genes are required for the disease to become manifested . known exogenous triggers are skin aggression ( 35 ) , infections ( 36 - 38 ) , alcohol and tobacco ( 39 - 45 ) , stress ( 43 - 46 ) , drugs ( lithium , beta - blockers , antimalarials , ace - inhibitors , nsaids ) . ( 47 - 54 ) endogenous triggers are hormonal changes ( 55,56 ) and allergies ( 57 , 58 ) . the study was conducted in the dermatology department of the  nene teresa  university hospital , tirane , during the period from january to november 2012 . a sample of 90 patients with psoriasis , 45 men and 45 women above 18 years - old were included , either with recurrent disease or their first flare - up . the interviews were carried out using two questionnaires : the first inquiring about potential trigger factors and the second assessing the quality of life . the aim was to identify the importance of trigger factors in the outburst and exacerbation of psoriasis in our sample and the impact of the disease on their quality of life . more than 70 % of patients reported that stressful events cause their psoriasis to flare - up of . using the 2 test , a significant difference was found between patients who experienced stressful events and those who did not ( p < 0.05 ) . this confirmed stress as a trigger factor in both males and females of our sample . more than 60% of males and 20% of females were smokers . statistical analysis yielded a significant difference between smoking and non - smoking females ( p < 0.05 , regardless of the number of cigarettes ) . statistical comparison between the groups of drinkers and non - drinkers resulted statistically significant ( p<0,05 ) . about 20% of our patients were taking one or more of the medications listed in the questionnaire . comparison of the group that received drugs ( at least one ) with the group that did not receive any resulted statistically insignificant ( p > 0.05 ) . about 20% of patients reported having had recurrent infections . comparison of the group reporting recurrent infections with the group not reporting resulted statistically significant ( p<0,05 ) . statistical comparison between the groups reporting skin aggressions and not resulted significant ( p<0,05 ) . about 36% of females reported the effect of hormonal changes in the exacerbation of psoriasis . they are a trigger factor for psoriasis in female patients of our sample . in this study the most affected areas are everyday activities , professional activities , relationships with family members and friends . most of the patients avoid public interaction , dress to hide their condition and feel like outcasts ( 64% ) . psoriasis affects daily interpersonal interactions in four out of ten ( 38% ) interviewed subjects . for those with severe psoriasis , this increases to 57% . three fourths ( 74% ) do not like being in public during a flare- up . in the recent years , there has been an increase in the number of instruments for assessing the quality of life of psoriasis patients and the role of risk factors in the onset of disease . the cv-50 questionnaire is a specific instrument dedicated to cutaneous diseases and comprises 18 questions . it can be used to assess and compare the quality of life among different skin conditions . the score ranges from 10 to 50 , the higher the figures , the deeper the impact on quality of life . the cv-50 questionnaire assesses the impact of psoriasis in four directions : daily activities , job or school , entertainment and personal relations . the patient must recollect his last week and gauge the influence of psoriasis in each of these fields . based on the answers yielded by the questionnaire , the fields on which psoriasis had the greatest impact were daily activities and relaxing activities . the results pointed out that the biggest emotional upsets were noted when the disease was located in the face , neck and genital region . for most cutaneous diseases , a case - control study represents one of the epidemiological - analytical methods used to test the correlation between risk factors and specific disease frequency . the genetic bases of psoriasis are well - known , its occurrence being under the influence of various factors that can cause the onset , aggravation or remission as well as contribute to chronicization and therapeutic failure . the present study has been designed to investigate the correlation with selected risk factors : alcohol consumption , smoking , stress , medications , recurrent infections , family history , cutaneous aggressions , allergies and hormonal changes . the study showed that 50% of psoriasis patients blamed stress as the cause of their disease , with a significant difference . various studies related to the assessment of stressful life events have pointed out that stress can induce the occurrence of the disease , with early onset psoriasis ( < 40 y.o . ) smoking seriously affects internal organs , especially the heart and lungs , but also influences the external appearance including the skin , weight and corporeal forms . the present study , like many similar ones ( 41 - 45 ) , revealed a significant difference between smokers and non - smokers , especially among women . many studies showed that alcohol consumption is closely correlated to the onset of disease ( 39 - 43 , 45 ) . 80 % of the male psoriasis patients included in the present study consumed alcohol in various amounts . as for hormonal changes , as in other studies ( 56 ) , it was noted that they influenced in the aggravation of disease in 36% of female patients . a vast number of clinical reports show that bacterial infections can induce the occurrence of psoriasis and it is well known that disease aggravations are often preceded by streptococcal infections . ( 36- 38 ) in the present study 20% of the patients confirmed that they had recurrent infections . stress , tobacco , infections , alcohol , hormones , skin aggressions were confirmed as trigger factors in this study . it was found that the disease affects the quality of life in more than 40% of patients . the scale of impairment from psoriasis is comparable to other chronic diseases like diabetes or asthma . it is important to point out that the same degree of gravity may have a different impact on different patients , depending on individual characteristics and lifestyles . it is crucial to evaluate the perception of the psoriatic patient about other medical conditions , disabilities and quality of life in order to tailor an adequate individual treatment schedule .
objective : to evaluate the role of stress , tobacco , drugs , infections , allergies , heredity , alcohol , hormones and skin aggressions as trigger factors and the impact on quality of life in a sample of psoriasis patients.methods:a transversal study performed in 90 patients affected by psoriasis between january and november 2012 at the  nene tereza  university hospital , tirane , albania , based on two scored questionnaires.results:more than 70 % of patients reported that stressful events caused a flare- up of their psoriasis ( p < 0.05 ) . more than 60% of males and 20% of females were smokers ( p < 0.05 ) . 
 about 20% of our patients were taking one or more of the medications listed in the questionnaire ( p > 0.05 ) . 
 about 20% of patients reported having had recurrent infections ( p<0,05 ) . 
 about 80% of males patients consumed alcohol ( p<0,05 ) . 
 more than 40% reported a relative with psoriasis . 
 statistical comparison of the group that reported skin aggressions with the group that did not revealed a significant difference ( p<0,05 ) . 
 only a few of them reported to have allergies ( p>0,05 ) . 
 about 36% of females reported that hormonal changes ( puberty and menopause ) exacerbated their psoriasis ( p<0,05 ) . 
 more than 40% of patients reported that psoriasis seriously affects their quality of life.conclusion:stress , tobacco , infections , heredity , alcohol , hormonal changes and skin aggressions were confirmed as trigger factors for psoriasis in the present sample . 
 allergies and the investigated drugs seemed not to have any influence in flare - ups . 
 we found that psoriasis had a serious impact in the quality of life in over of 40% of the patients interviewed .