more than 1.2 million inguinal hernia operations are performed each year in the united states , europe , and australia , and > 20 million hernias are estimated to be repaired annually worldwide . the use of mesh in hernia repair has reduced the recurrence rate by 50% to 75% . there are > 50 different commercial varieties of mesh : polypropylene , polyglactin , polypropylene - polyglactin , -d - glucan , titanium - coated polypropylene , polypropylene - poliglecapron , polytetrafluoroethylene , collagen , and so on . laparoscopic repair is a commonly recommended procedure for recurrent and bilateral inguinal hernias and is used successfully also in unilateral inguinal hernia repair . postsurgical complications include hernia recurrence and chronic postoperative pain , which partially correlate with the dissection technique , the mesh type , and mainly the technique of mesh fixation . in recent years , a novel self - gripping mesh made of lightweight polyester and polylactic acid containing microgrips has become commercial and is indicated for inguinal hernia repair . kapischke et al demonstrated its beneficial effect on postoperative pain in lichtenstein - type open hernia repairs , and recently , several research teams have shown favorable results in transabdominal preperitoneal ( tapp ) laparoscopic hernia repair using the progrip self gripping mesh ( covidien , dublin , ireland ) . however the use of this novel mesh requires greater laparoscopic skill and dexterity because of the rapid adhesive qualities of the mesh . we hypothesized that gel - like coverage of the parietene progrip mesh with a water - soluble film would allow controlled delay in the immediate surface adhesion of the mesh to the tissue . we decided to examine the ease of use and adherence efficacy of gel - covered self - gripping mesh on bovine myofascial tissue and porcine abdominal wall , which might allow greater understanding of possible clinical applications in general hernia repair and in laparoscopic hernia surgery in particular . gelatin film was prepared by dissolving 28 g of purified gelatin ( bovine ) in 120 ml water at 80c . four quadrangular identical pieces of progrip mesh ( 55  60 mm ) were prepared . three pieces were covered with the heated liquid gelatin ( approximately 1.5 mm ) and left to cool and solidify . a fresh myofascial specimen from the paravertebral region was resected and sized to 200  100 mm . a fresh abdominal wall specimen was resected , ex vivo , from a female pig , domestic breed ( large white x landrace , sus scrofa domestica ) . the specimen contained all layers of the abdominal wall , including muscle , fat tissue , and fascia . 20 scalpel blade ( figure 1 ) , after which a 400  300 mm preperitoneal surface was exposed . preparation of porcine abdominal wall specimen : removal of peritoneal layer . for the bovine tissue , dislodgement shear force ( dsf ) was defined as the maximal applicable force before the initiation of movement . dsf was measured using a mark-10 dynamometer ( 50  0.02 n ) ( bg series ; mark-10 corporation , copiague , ny ) . after dsf measurement , the gel film from the gel - coated mesh pieces was dissolved by irrigating 15 ml of saline solution warmed to 37c . fixation of the mesh was achieved by gently pressing the mesh against the underlying tissue . dsf measurements were repeated approximately 3 consecutive times for each of the mesh pieces in each tissue type . six measurements were recorded for the control meshes , 16 measurements for the gel - coated meshes , and 15 measurements for the dissolved - gel meshes . data were analyzed with the r language and environment for statistical computing version 3.0.2 ( r foundation for statistical computing , vienna , austria ) . gelatin film was prepared by dissolving 28 g of purified gelatin ( bovine ) in 120 ml water at 80c . four quadrangular identical pieces of progrip mesh ( 55  60 mm ) were prepared . three pieces were covered with the heated liquid gelatin ( approximately 1.5 mm ) and left to cool and solidify . a fresh myofascial specimen from the paravertebral region was resected and sized to 200  100 mm . a fresh abdominal wall specimen was resected , ex vivo , from a female pig , domestic breed ( large white x landrace , sus scrofa domestica ) . the specimen contained all layers of the abdominal wall , including muscle , fat tissue , and fascia . 20 scalpel blade ( figure 1 ) , after which a 400  300 mm preperitoneal surface was exposed . for the bovine tissue , mesh pieces were placed on the fascial surface . for the porcine tissue , dislodgement shear force ( dsf ) was defined as the maximal applicable force before the initiation of movement . dsf was measured using a mark-10 dynamometer ( 50  0.02 n ) ( bg series ; mark-10 corporation , copiague , ny ) . after dsf measurement , the gel film from the gel - coated mesh pieces was dissolved by irrigating 15 ml of saline solution warmed to 37c . fixation of the mesh was achieved by gently pressing the mesh against the underlying tissue . dsf measurements were repeated approximately 3 consecutive times for each of the mesh pieces in each tissue type . six measurements were recorded for the control meshes , 16 measurements for the gel - coated meshes , and 15 measurements for the dissolved - gel meshes . data were analyzed with the r language and environment for statistical computing version 3.0.2 ( r foundation for statistical computing , vienna , austria ) . analysis of the results from the bovine specimen revealed that gel coating of the mesh reduced dislodgement forces by 61% ( 12.39  2.16 vs 4.76  2.17 n , p < .03 ) . dissolving the gel markedly increased the dsf ( 18.60  4.56 vs 4.76  2.17 n , p < .003 ) , and after dissolving the gel , the dsfs were similar and noninferior to the control mesh ( 12.39  2.16 vs 18.60  4.56 , p = ns ) . dislodgement shear force measurement in bovine myofascial specimen ( control vs gel - covered [ gel - p ] vs dissolved gel [ disgel - p ] ) . analysis of the results from the porcine abdominal wall specimen revealed that gel coating of the mesh reduced dislodgement forces by 81% ( 8.05  0.66 vs 1.53  0.82 , p < .01 ) . dissolving the gel markedly increased the dsf ( 10.62  3.70 vs 1.53  0.82 n , p < .0001 ) , and after dissolving the gel , the dsfs were similar and noninferior to the control mesh ( 8.05  0.66 vs 10.62  3.70 n , p = ns ) . dislodgement shear force measurement in porcine abdominal wall ( control vs gel - covered [ gel - p ] vs dissolved gel [ disgel - p ] ) . suitable mesh selection , accurate mesh placement , and prevention of mesh migration have been noted as factors affecting the recurrence of hernia . however , the technique of mesh fixation remains controversial because it has been demonstrated that pain after laparoscopic inguinal hernia repair is a significant problem that might be associated with the type of fixation . recent studies have shown that mesh fixation with metal tacks results in increased rates of chronic postoperative pain , and some support the use of fibrin glue as an adhesive for mesh fixation . in view of these challenges , however , the use of this mesh in laparoscopic inguinal hernia repair has so far been limited to tapp repair and requires greater dexterity and manual skill than the use of regular mesh . according to birk et al , because of the self - gripping qualities of the progrip mesh , it folds and attaches to itself when inserted through the trocar and requires disentanglement and straightening to avoid mesh folding or twisting during placement . in this study , we set out to modulate the self - gripping design of the progrip mesh to transform it into an easily applicable mesh for totally extraperitoneal and tapp repairs . this was achieved by using a thin , water - soluble gel coating to limit the contact of the tissue with the microgrip surface . this study 's results show that tissue adhesion was markedly lowered by the gel coating and that removal of the gel allowed the mesh to regain full self - gripping abilities without any reduction compared with the control mesh . further in vivo trials ( open and laparoscopic ) are needed to assess the clinical relevance of this model . if these trials prove efficacious , use of this modification to tapp hernia repair can allow the surgeon to preoperatively prepare the gel film coating , roll and insert the mesh through the trocar , easily place the mesh on the exposed preperitoneal window , dissolve the mesh with warmed saline , and close the peritoneal flap . a similar procedure may be used in totally extraperitoneal hernia repair , without need for tacks or glue . our study was preliminarily designed to assess control of the mesh 's self - gripping ability , which has been implicated as a causative factor in the difficult operative handling of the mesh . although critical for clinical assessment , operative ease of use in the laparoscopic setting was not an end point of our study , because of the obvious addition of biasing factors , and future studies assessing the laparoscopic use of our modification of the self - gripping mesh are warranted . although more tests are needed for in vivo evaluation of this mesh in tapp and totally extraperitoneal repairs , as well as histologic assessment of tissue response to the mesh , we believe this modification holds great promise and certainly merits further testing . water - soluble gel coating significantly decreases attachment forces of the progrip mesh and does not impair self - gripping properties after dissolving of the gel . this technology may simplify the use of self - gripping mesh in open and laparoscopic hernia repair by controlling the time of activation of the self - gripping properties of the mesh . further in vivo studies
background : mesh hernia repair is one of the most frequently performed procedures in general surgery . 
 recently , use of the self - gripping mesh demonstrated a beneficial effect on postoperative pain in inguinal hernia repairs . 
 however , in intra - abdominal placement , the use of this novel mesh requires greater laparoscopic skill and dexterity because of the mesh 's tendency to fold and adhere to itself and to any surrounding tissues . 
 we hypothesized that gel - like coverage of a self - gripping mesh with a water - soluble film would allow delaying the immediate surface adhesion of the mesh to the tissue , which may allow greater freedom and ease in mesh placement for laparoscopic surgeons.methods:in this ex vivo animal study , gel - coated self - gripping mesh ( progrip ) was compared with a control uncoated mesh in bovine and porcine tissue specimens and assessed for dislodgement shear forces before and after dissolving of the gel.results:gel coating of the mesh reduced preperitoneal dislodgement forces in a porcine abdominal wall specimen by 81% ( 8.05  0.66 vs 1.53  0.82 n , p < .01 ) . dissolving the gel 
 markedly increased the anchoring forces ( 10.62  3.70 vs 1.53  0.82 n , p < .0001 ) , and after dissolving the gel , the mesh shear dislodgement forces were similar and noninferior to the control mesh ( 8.05  0.66 vs 10.62  3.70 n , 
 p = ns).conclusions : we believe that water - soluble gel coating does not impair the adhesive features of the self - gripping mesh and may simplify its use in open and laparoscopic procedures by allowing controlled activation of the self - gripping mechanism .