sexual health is an important aspect of women 's health that affects the well - being and quality of life , both for the women themselves and for their spouses . during the menopausal transition , sexual desire is an essential domain of sexual function because low desire can be caused in low sexual relations . ( 2006 ) reported that there was significant correlation of desire with other domains of female sexual functioning . women with low desire are also highly likely to experience low arousal , pleasure , or orgasmic difficulties . overall , the results show that women with low desire have , on average , a very different sexual experience than women without low sexual desire . these findings indicate that restoring a woman 's sexual desire may help to improve her satisfaction with her own sexual functioning and with the intimate relationship between her and her sexual partner . hormone replacement therapy ( hrt ) is the most effective method for relieving sexual function , but some studies mentioned concerns about its side effects . therefore , investigators are looking for both complementary and alternative medicine ( cam ) that has the same benefit but with minimized risks . although some alternatives are not as effective as hrt , a reduction in symptoms may be sufficient . it facilitates blood flow , influences nitric oxide systems , and has a relaxant effect on smooth muscles , all of which are important in the female sexual response , but controversy remains concerning its effects on sexual desire . most of the illnesses relieved by ginkgo are associated with old age , a time of life when the blood flow deteriorates . although some studies show a positive effect of gbe alone or in combination with other supplements on sexual desire , other studies have not reported any significant effect . therefore , the goal of this study was to assess the effect of g. biloba extract on sexual desire in women aged 50 - 60 years . in this study approved by the research ethics committee of tehran university of medical sciences ( tums ) , 80 healthy volunteers attending three healthcare centers of tums in the west of tehran were enrolled in the study during summer and autumn 2010 . all the study participants were women aged 50 - 60 years , who had begun experiencing menopausal symptoms at least a year back . none of them was receiving hrt , and neither they nor their spouses had any acute or chronic physical or psychological diseases . all the participants were literate and had sex at least twice during the study period of 30 days . the other exclusion criteria included consuming g. biloba capsules for less than 3 weeks , any serious medical conditions , and not having sex at least once during the study period . this triple - blind , placebo - controlled trial investigated the effects of gbe at a dose of 120 - 240 mg on sexual desire , as assessed by the sabbatsberg sexual rating scale ( ssrs ) , which is a valid and reliable questionnaire ; its persian version has previously been used in various studies in iran . the first part covered personal characteristics , including age , time of last menstruation , number of coitus , number of children , education , occupation , and economic status of the volunteers , and age , education , and occupation status of their spouses . the second part of the assessment used the ssrs , which measured sexual function before initiation of intervention and after 1 month of therapy . the part of ssrs measured sexual desire which assess sexual desire in the last month and in comparison to the previous years . the response options differed between the questions , but they were based on a 5-point likert scale rating system . the ssrs has six domains ( sexual desire , activity , satisfaction , arousal or pleasure , orgasm , and importance of sex ) and each domain has two items , six of which assess different aspects of sexual function in the last month , while six others assess different aspects of sexual function in comparison to the previous years . the response options differed between the questions , but they were based on a 5-point likert scale rating system . the responses to each question were summed and converted to a percentage , producing a  sexual rating  between 0 and 100 . after a detailed explanation of the procedure and general objective of the study was given to the participants , they provided informed consent , and were randomly assigned to the gbe or placebo group ( a and b bottles ) . since the study was triple - blind , only the pharmacist knew the identity of each type of capsule , which means that apart from the participants and investigator being blind to the treatment , the statistician was also blinded until the analysis was completed . the two bottles were completely same ; therefore , investigator and participants were not aware of the content of the bottles . each g. biloba capsule contained 60 mg of gbe , while the placebo capsules contained pea powder and wheat blossom . the treatment group received gbe capsules ( 60 mg ) , twice daily for 1 week , and the control group received placebo capsules , following the same regimen as the gbe group . participants who tolerated the capsules received them at a dose of 60 mg four times a day for the remainder of the study . all the participants were followed up weekly by telephone . at the end of each week , the research group called the participants and asked them if they had experienced any complications during the test period , such as nausea , vomiting , or epigastric pain . of the 80 participants who were enrolled in this study , 63 women successfully followed and completed the study protocol . this reduction in sample size was attributed to the following reasons : not having sex at least twice during the study period ( n = 1 ) , diagnosis of diabetes ( n = 3 ) , diagnosis of hypertension ( n = 2 ) , use of aspirin ( n = 2 ) , and irregular consumption of the capsules ( n = 6 ) . after a month the scores were measured , compared , and analyzed for the two groups before and after the intervention . all ethical considerations considered and approved by research chancellor of tehran university of medical sciences . all 63 participants completed the ssrs for the second time following the intervention . to assess the equivalence of the two groups , personal characteristics were analyzed . no significant differences were noted in the personal characteristics of the two groups regarding age , time of last menstruation , number of coitus , number of children , education , occupation , and economic status of the volunteers , and age , education , and occupation status of the spouses [ table 1 ] . personal characteristics of women in placebo and ginkgo biloba groups the results of mann  whitney test showed equality of sexual desire of the ssrs before intervention in the two groups and no significant difference between the mean scores in sexual satisfaction [ tables 2 and 3 ] . sexual desire during last month in the two groups before and after intervention sexual desire in comparison to previous years in the two groups before and after intervention after intervention , significant difference was found between the groups in the sexual desire ( p = 0.02 ) during the previous month [ table 2 ] , whereas no difference was found between the sexual desire in comparison to the previous years [ table 3 ] . in spite of the high prevalence of sexual dysfunction in women , only few clinical trials have been conducted for potential treatments . the aim of this study was to investigate the effect of gbe on sexual desire in menopausal women , as some previous studies had reported a significant improvement in sexual function after using gbe . cohen and bartlik in an open clinical trial showed that gbe at a dose of 120 - 240 mg was 84% effective in treating sexual dysfunction due to antidepressant drugs . gbe generally had a positive effect on all four phases of the sexual response cycle ( desire , excitement , orgasm , and resolution ) . ito et al . in a double - blind placebo - controlled study of arginmax ( a nutritional compound consisting of the extracts of ginseng , ginkgo , and damiana , and l - arginine , multivitamins , and minerals ) showed that after 4 weeks , the arginmax - treated group reported an improvement in sexual desire . the same researchers in another study reported the effects of the same supplement on sexual function in pre- , peri- , and postmenopausal women . in pre - menopausal women , this supplement had positive effects on sexual desire , sexual satisfaction , frequency of sexual desire , and frequency of intercourse compared to the placebo group . in the peri - menopausal women , this supplement had positive effects on the frequency of intercourse , sexual satisfaction , and vaginal dryness compared to the placebo group , while vaginal dryness , sexual activity , and clitoral sensation had not been improved . postmenopausal women showed a slight but significant improvement in sexual desire . in this study , however , we found that gbe was not effective in increasing sexual desire in comparison to previous years . in contrast to the result of this study , wheatley ( 2004 ) did not report any significant difference in sexual function after gbe therapy . the method of consumption was the same , but the participants were also consuming antidepressant drugs . in another study , meston et al . showed that a single dose of 300 mg of gbe had not a small but significant effect on sexual desire compared to the effect of placebo in women . since gbe is considered a safe supplement with weak estrogenic activities , it may be a suitable method of replacement therapy for treating menopausal symptoms . in this study , we found that gbe had a positive effect on the sexual desire of menopausal women ; therefore , the investigators suggest that it may have effects on improving the sexual function in menopausal women . this study found that gbe had a positive effect on the sexual desire of menopausal women ; therefore , the investigators suggest that gbe may improve sexual function in menopausal women .
background : during the menopausal period , sexual desire may decrease . therefore , restoring the sexual desire may help to improve sexual functioning in this group of women . 
 the aim of this study was to examine the effect of ginkgo biloba extract ( gbe ) on sexual desire in postmenopausal women.materials and methods : in this triple - blind , randomized , placebo - controlled trial , 80 healthy female volunteers attending three healthcare centers of tehran university of medical sciences ( tums ) were enrolled . 
 the instrument of this study had two main parts . 
 the first part covered the personal characteristics of the volunteers and the second part used the sabbatsberg sexual rating scale ( ssrs ) to subjectively evaluate sexual desire before and after intervention . 
 the participants received gbe at a dose of 120 - 240 mg ( n = 40 ) or received placebo ( n = 40 ) daily for 30 days . 
 the results were analyzed using mann 
 whitney test . 
 all analyses were performed using spss software.results:the sexual desire was significantly improved in the gbe group compared to the placebo group ( p = 0.02).conclusions : in this study , we found that gbe had a positive effect on sexual desire of menopausal women ; thus , these findings support the positive effect of gbe on the sexual function of menopausal women .