inflammatory myofibroblastic tumor ( imt ) is a rare benign lesion with a controversial etiology that mimics malignant neoplasm ( 1 ) . it affects various tissues and organs ( genitourinary tract , lung , and retroperitoneal space in different age groups ( 2 ) . clinical appearances of inflammatory pseudotumor ( ipt ) include inflammatory and reparatory processes , and myofibroblastic pseudosarcomatous proliferation ( 3 ) . inflammatory myofibroblastic tumor consists of spindle cells , acute and chronic inflammatory cells , and fibro - vascular stroma . concerning predominant tissue component , histomorphology , ultrastructure and immunohistochemical analyses of imt are complex when a variety of benign and malignant lesions has to be excluded ( 3 , 5 , 6 ) . first , detection of fibronexus and peripherally arranged contractile fibers by means of electron microscopy , positive immunostaining for smooth - muscle actin , desmin , calponin , fibronectin , some keratins and anaplastic lymphoma kinase ( alk ) raise the possibility that spindle cells are truly myofibroblasts ( 3 , 5 ) . second , benign myofibroblastic and fibroblastic lesions express alk positivity with various expressions due to the anatomic site of the lesion while sarcomas do not . from the previously mentioned , leiomyosarcoma and fibrosarcoma might be separated from imt ( 1 , 3 , 4 , 7 ) . third , differentiation from idiopathic inflammatory lesions is based upon the higher percentage of cellularity and from the lymphoma by the presence of various clones of t and b lymphocytes ( 3 , 5 ) . a large amount of tissue specimen is necessary for such profound analysis and percutaneous biopsy is not advocated ( 1 , 3 ) . besides detection and evaluation of tumor extension , radiological presentation of imt does not contribute to its characterization . spontaneous regression of abdominopelvic imt is reported extremely rare in non - surgically treated patients ( 8 - 10 ) . the gradual , complete regression of uterine imt documented by computerized tomography ( ct ) and magnetic resonance imaging ( mri ) may contribute to the understanding of its nature . a middle - aged female patient was admitted to the hospital with a 5-month history of febrile condition , weight loss , left lumbar pain , and edema of the left leg . laboratory findings revealed an accelerated sedimentation rate , hypochromic anemia , leukocytosis , and a mild rise in serum creatinine level . abdominal ultrasound and intravenous urography depicted bilateral hydronephrosis and a large , soft tissue mass occupying the pelvis . bimanual vaginal and rectal examination confirmed pelvic mass involving the uterus , parametria , and mostly the left adnexa . cystoscopy with biopsy did not show any abnormality and rectosigmoidoscopy showed extrinsic lumen narrowing with negative biopsy findings . a detailed clinical evaluation of this patient has been presented in the previous report ( 10 ) . the first ct revealed an enlarged uterus with homogeneous wall thickening and indistinct outer and inner margins . after an intravenous contrast administration , the mass density raised heterogeneously ( 10 to 20 hu ) without evidence of necrosis or calcification . soft tissue planes between the uterus and bowels , ureters and both ovaries were erased ( figure 1 ) . the tumor was of rubbery consistence tightly adherent to pelvic organs and the sacrum . because a complete tumor excision was technically impossible , bowel liberation and excisional biopsy were performed . routine hematoxylin - eosin ( he ) stain showed hyalinized stroma with myofibroblasts and numerous inflammatory cell infiltrates ( figure 2 ) . immunohistochemical analysis verified spindle cell positivity for actin and vimentin , inflammatory cell positivity for lca and cd68 , and vascular vessel wall positivity for anti - cd34 antibody . immunohistochemical findings were negative for desmin , s-100 , cytokeratin hmv , and focally positive for cytokeratin mnf116 . meanwhile , the patient underwent unilateral ( right ) percutaneous nephrostomy ( pcn ) catheter insertion . inflammatory symptoms and laboratory findings returned to normal within three months when pcn was extracted . then , 4 months after surgery , the second ct depicted reduction of the tumor volume while its densities on both unenhanced and enhanced scans remained identical with the first ct . eight months after the initial work - up , further tumor regression was noted with iso- and hypodense strands of tumor tissue arranged in the radial fashion connecting uterus and pelvic walls ( figure 3 ) . further on , ultrasound checkups were done periodically every 6 months , in which uterus wall thickening and its indistinct outer border were present . two years after the initial diagnosis , follow - up ct depicted complete tumor regression with restoration of pelvic organ morphology and involution of the uterus to dimensions appropriate to the patient s age . the only apparent abnormality was an invisible fat tissue plane between the uterus and the adjacent bowel loops , thus suggesting adhesions ( figure 4 ) . mri exams were done during the third , fourth and fifth year of follow - up . in t1 weighted fat suppression sequence , t2 weighted fat suppression sequence , fast spin echo sequence , pelvic organs with normal topography and morphology without residual periuterine fibrosis were depicted . the uterus corpus , cervix zone anatomy , and the width of the endometrium were within normal limits ( figure 5 ) . diffusion weighted images were obtained during these mri exams and no apparent changes were observed ( figure 6 ) . the majority of published reports refer imt under several names such as ipt ( inflammatory pseudotumor ) or inflammatory myofibrohistiocytic proliferation , but the histological entity is the same ( 3 ) . the real incidence of imt is unknown and the proper evaluation may often be doubtful ( 2 ) . reports on imt ( inflammatory pseudotumor ) of the uterus in 11 female patients , aged 6 to 63 , have been published ( 11 - 13 ) . clinically , these cases presented themselves with constitutional symptoms , symptoms due to the local tumor growth and its mass effect , while some were asymptomatic . in all the published reports except one , tumors were surgically excised and the diagnosis was made by histological and immunohistochemical study . spindle cells contained in imt were positive on smooth muscle actin in all cases . in recent reports , published after 2003 two types of growth pattern were observed : intracavitary- polypoid ( five patients ) and extracavitary- infiltrative ( six patients ) . localized , polypoid form of uterine imt did not invade the endometrium and was indistinguishable from leyomyoma by means of imaging ( 12 ) . the case of uterine imt in which decrease and normalization of the serum level of il-6 occurred after surgical excision emphasized the inflammatory component of imt ( 13 ) . in these reports , apart from detection and staging , little attention has been paid to the imaging presentation of uterine imt . concerning its imaging characterization , therefore , very few papers have been published about the radiological presentation of abdominopelvic imt ( 8 , 14 ) . polypoid form of imt is referred to other hollow structures such as the bowels , ureter and urinary bladder ( 8 , 14 , 15 ) . calcium deposits are observed in liver , pelvic , pancreatic and stomach imt ( ipt ) . imt on noncontrast ct scans can be isodense or hypodense when compared to skeletal muscles . the necrosis is presumed possible in large volume imt . it can be homogeneous , heterogeneous , early peripheral or late central ( 14 ) . mri presentation of imt also varies significantly . a majority of cases of imt were isointense and hypointense in t1w sequences and hyperintense in t2w sequences compared to the surrounding muscles . the different degree of hyperintensity in t2w sequences correlates with the amount of fibrotic component revealed histologically . some authors imply that an increase in tumor hyperintensity in t2w sequences stresses tumor evolution toward sclerosis and implicates good prognosis . partial tumor regression refers to a situation in which intensity parameters remain the same on the follow - up mri ( 9 ) . after contrast administration , imt shows heterogeneous increase in signal intensity thus making it impossible to differentiate it from various malignant lesions ( 9 ) . the contrast enhancement ( ct , mri ) depends on vascularization of the lesion and in case of imt , vascular pattern depends on predominant histological subtype and it does not correlate with benign / malignant nature , tumor extension or its prognosis . during the first two - year period of follow - up , we used ultrasound and ct imaging in order to obtain more anatomical details . further on , we preferred mri imaging to avoid unnecessary radiation and to achieve better tissue differentiation . in imt , the word a causative , infective agent is detected in imt of the spleen , lymph nodes ( epstein barr virus ) and in some cases of lung imt ( mycoplasma ) ( 6 ) . success with steroid treatment in cases of imt of the lung and resolved constitutional symptoms with normalization of il-6 , and il-1 serum levels after surgery implicate inflammatory etiology of some imts ( 12 , 13 ) . in our case , complete resolution of clinical signs and laboratory abnormalities were accompanied by a decrease in tumor volume . however , the tumor mass was still significant at that time . restored kidney function remained stable after extraction of pcn . this indicates that although still present , tumor does not compress ureters significantly ( second ct ) . normal morphology of the pelvicaliceal system of both kidneys and normal serum creatinine level persistent after 4-year follow - ups are indirect signs that tissue restoration was complete and with no evidence of ureteral or periureteral fibrosis . during tumor regression , no sign of necrosis or abscess formation was evident on ct exams . tumor volume decreased gradually from the periphery toward the uterus , while the enhancement pattern ( slightly higher at the outer tumor margins ) remained unchanged . restoration of the pelvic organ morphology in such a manner is called  rewind backwards  . it is similar to any inflammation extension , only in the opposite direction . at the end of follow up this report of complete imt regression contributes to the benign , immunologically mediated nature of some imts . however , all authors agree that thorough follow - up is mandatory in all cases of imt ( ipt ) . this attitude is supported with cases of imt recurrence years after the surgery as well as with secondary malignancies that were either undetectable or the imt was improperly diagnosed from the beginning ( 2 , 7 , 8) . controversial etiology including trauma , infection , and malignancy , and no specific immunohistochemical and genetic abnormalities implicate that imt is the diagnosis of exclusion ( 3 , 5 , 6 ) . in which the data suggest that previous trauma and constitutional symptoms are present , imt should be encountered in the differential diagnosis of the pelvic mass . absence of necrosis , the  rewinding backwards  type of regression without residual fibrosis emphasize the fact that imt was of benign nature , and that the uterus is the site of origin . this is the first radiologically documented follow - up of gradual and complete regression of uterine imt .
inflammatory myofibroblastic tumor ( imt ) is an aggressive benign mass that may arise from various tissues and organs with a great variability of histological and clinical appearances . due to variable and nonspecific imaging findings , diagnosis of imt 
 is not obtained before surgery . 
 the aim of this paper is to present ct and mri findings during four - year follow - up of complete , spontaneous regression of imt of the uterus . 
 the diagnosis was made by histology and immunohistochemistry analysis of the open excisional biopsy specimen . at that time , the organ of origin was not specified . 
 after analysis of the follow - up imaging findings and the mode of tumor regression , the uterus was proclaimed as the probable site of origin . 
 imt of the uterus is extremely rare and has been reported in ten cases up to now . 
 the gradual , complete regression of uterine imt documented by ct and mri may contribute to understanding of its nature .