anorexia nervosa ( an ) is a serious psychiatric disorder affecting mainly young females and it is associated with poor long - term outcome.1 according to the current version of the diagnostic and statistical manual of mental disorders , the essential features of an are a significantly low body weight for the developmental stage of the subject , an intense fear of gaining weight or persistent behavior that interferes with weight gain , and disturbance in experiencing body weight and shape.2 two different subtypes of the disorders are specified , the restricting type ( an - r ) , in which weight loss is accomplished exclusively through a massive reduction in food intake and excessive exercise over the previous 3 months , and the binge - eating / purging type ( an - be ) , in which binge eating is usually associated with purging through self - induced vomiting or misuse of laxatives and diuretics or enemas during the previous 3 months.2 despite neither diagnostic criteria nor reports on common associated psychopathology describe empathic alterations in an , clinical observation as well as some research data suggests that empathic difficulty could be part of the an phenotype.3 empathy is a complex multidimensional construct and a core component of social cognition . a schematic distinction of empathy includes : a ) sharing the emotional states of others ( affective empathy [ ae ] ) , and b ) understanding the perspective of another person ( cognitive empathy [ ce]).4 a phenomenon partially overlapping with empathy is theory of mind ( tom ) . tom consists of the ability to make inferences regarding others emotions ( affective or emotional tom ) or beliefs and motivations ( cognitive tom ) ; while the latter is strongly similar to ce , the former may be related to both affective and cognitive empathy.5 a considerable subgroup of an subjects with associated empathy disorders was revealed in a gillberg et al study:6 the authors described these patients as impaired in understanding the cognitive and emotional perspectives of other people and with a clinical picture suggestive of an autism spectrum disorder ( asd ) . subsequent reports confirmed autistic traits as predictive1 or comorbid factors in an patients:7 this has led some authors to consider an as a version of asd.8 however , an impaired empathic profile in an is not a consistent finding ; for example , a self - report evaluation of empathic abilities failed to detect statistically significant differences between an patients and healthy controls.9 on the other hand , tchan - turia et al10 first explored cognitive tom in women with an , revealing a clear impairment in a subgroup of these patients of which the study lacked the power to demonstrate statistically . later reports showed abnormalities in both affective and cognitive tom,11 in emotional tom only,12 or no relevant differences between adult patients with an and controls in emotional tom.13 finally , a recent investigation that evaluated , among other things , the social perception domain through a multidomain neuropsychological battery designed specifically for children and adolescents , reported an absence of deficit in this area in an - r patients.14 the assessment of empathic response can be performed through physiological measurements ( eg , heart rate or skin conductance registration ) , indirect indices ( facial , gestural , bodily , and vocal expression recognition ) , and psychological evaluation ( test administration , reports from significant others , and self - reported questionnaires ) . among self - reported psychological tests aimed at evaluating empathic functioning , the interpersonal reactivity index ( iri ) represents one of the most widely used and comprehensive instruments.4 in fact , different abnormalities in ce and ae levels , assessed through the iri , have been reported in a variety of psychiatric conditions , including psychopathy,15 borderline personality disorder,16 asperger syndrome,17 schizophrenia,18 major depressive disorder,19 bipolar disorder,20 and patients with alcohol dependence.21 to our knowledge , no study has evaluated empathy abnormalities in adolescents with an - r . in this study , we analyzed the empathic abilities of a homogeneous group of adolescents with an - r . as an - r subjects are characterized by starvation and associated internalizing psychopathology that can impact cognitive abilities,22 we specifically investigated the empathic profile controlling for disease severity and associated psychopathology . thirty - two adolescent females ( mean age  standard deviation [ sd ] = 14.78  1.75 years ; range = 11.0017.33 years ) with an - r were consecutively recruited from the inpatient eating disorders unit at the irccs stella maris foundation . these adolescents ( all between 11 and 18 years ) were characterized by restrictive behaviors and weight loss purely by dieting without binge eating or purging behaviors . they fulfilled the criteria for the diagnosis of an - r according to the diagnostic and statistical manual of mental disorders , 4th edition ( dsm - iv).23 patients with psychotic symptoms , intelligence quotient [ iq ] below 80 , medical pathology not correlated with the eating disorder , current or history of substance abuse , and significant intrinsic instability requiring constant medical care supervision ( such as severe bradycardia , dehydration , or electrolyte imbalance ) were excluded . the mean body mass index was 15.07  1.54 kg / m and the mean duration of illness was 19.56  18.38 months . twenty - seven patients ( 84.38% ) fulfilled the criteria for an axis i anxiety and/or mood disorder ( assessed through the italian version of the kiddie - sads - present and lifetime version [ k - sads - pl])24 and 3 of these 27 patients also met the criteria for an axis ii obsessive - compulsive personality disorder ( evaluated by the structured clinical interview for dsm - iv axis ii personality disorders).25 twelve patients ( 37.5% ) received psychopharmacological treatment with selective serotonin reuptake inhibitors and/or atypical antipsychotics and/or mood modulators , while the remaining 20 subjects were medication - nave . the an - r clinical sample was compared to a healthy control group ( hc ) composed of 41 healthy female adolescents recruited from students ( mean age = 14.02  1.69 years ; range = 11.0817.16 years ) of a middle and a high school in the metropolitan area of pisa . the following established measures , which were part of a larger suite of tests , were administered for this study . the iri is a 28-item self - reported questionnaire that allows a multi - dimensional assessment of empathy , which can be measured by two cognitive subscales ( perspective taking [ pt ] ; fantasy [ fs ] ) and two affective subscales ( empathic concern [ ec ] ; personal distress [ pd ] ) . participants respond to each item using a 5-point likert scale ranging from 2  does not describe me well  to + 2  does describe me well  . therefore the scores of each subscale range between 14 and + 14 points where higher scores indicate more empathic abilities . to address eating disorder severity , the following measures were considered : 1 ) the body mass index ( bmi ) calculated by dividing body weight in kilograms by height in meters squared ( kg / m ) ; 2 ) the eating attitudes test ( eat-26),27 a 26-item self - reported questionnaire of disordered eating patterns . the total score ranges from 0 to 78 ; a higher score reflects a greater degree of eating pathology , with a score over 20 indicating a possible eating problem ; 3 ) disease duration , defined as the time interval between the onset of the first eating disorder symptoms and the administration of the tests . to address psychopathological traits associated with the eating disorder , two questionnaires were used : 1 ) the child behavior checklist ( cbcl 618),28 a 118 item parent - reported measure designed to record the problem behaviors as well as the competencies of children or adolescents . each item describes a specific behavior and the parent is asked to rate its frequency on a 3-point likert scale . the scoring gives a summary profile including internalizing ( int ) , external - izing ( ext ) , and total problems ( tp ) , and a syndrome profile ( withdrawn , anxious / depressed , somatic complaints , social problems , thought problems , attention problems , delinquent behavior , and aggressive behavior ) ; 2 ) the youth self report ( ysr 1118 ) , an118 items self - reported questionnaire for adolescents from 11 to 18 years old.28 the ysr provides a summary profile and a syndrome profile paralleling those of the cbcl 618 . the study was carried out according to the standards for good ethical practice of the irccs stella maris foundation , and was approved by the educational board of each school of the hc group . patients and their parents completed all the tests ( iri , eat-26 , cbcl 618 , and ysr 1118 ) during the first days of the clinical assessment . hc , in addition to the iri , completed the eat-26 and the ysr 1118 , in order to rule out subjects with eating problems and/or axis i psychopathology , respectively . in fact , the ysr has been found to show a significant correlation with clinical dsm - iv diagnoses.2830 thus , subjects with an eat-26 score > 20 , and/or a score > 60 on int and/or ext and/or tp at the ysr , were excluded from the study . hc data were collected by a physician resident in child and adolescent psychiatry ( pf ) during school hours and informed consent was obtained from participants and their parents through the head teacher s office at each school . a student s t - test was used to compare differences in eat-26 , ysr , and iri mean scores between an - r and hc groups ; multivariate analysis of variance ( anova ) with eat-26 and with int , ext , and tp mean scores of the ysr as a covariate was used to identify iri scales discriminating between an - r and hc groups ; spearman correlations were adopted to assess the relationship between iri scales and 1 ) associated psychopathology ( cbcl ) , and 2 ) eating disorder severity ( bmi and disease duration ) , respectively . all statistical analyses were performed using spss 18.0 for windows ( ibm corporation , armonk , ny , usa ) . thirty - two adolescent females ( mean age  standard deviation [ sd ] = 14.78  1.75 years ; range = 11.0017.33 years ) with an - r were consecutively recruited from the inpatient eating disorders unit at the irccs stella maris foundation . these adolescents ( all between 11 and 18 years ) were characterized by restrictive behaviors and weight loss purely by dieting without binge eating or purging behaviors . they fulfilled the criteria for the diagnosis of an - r according to the diagnostic and statistical manual of mental disorders , 4th edition ( dsm - iv).23 patients with psychotic symptoms , intelligence quotient [ iq ] below 80 , medical pathology not correlated with the eating disorder , current or history of substance abuse , and significant intrinsic instability requiring constant medical care supervision ( such as severe bradycardia , dehydration , or electrolyte imbalance ) were excluded . the mean body mass index was 15.07  1.54 kg / m and the mean duration of illness was 19.56  18.38 months . twenty - seven patients ( 84.38% ) fulfilled the criteria for an axis i anxiety and/or mood disorder ( assessed through the italian version of the kiddie - sads - present and lifetime version [ k - sads - pl])24 and 3 of these 27 patients also met the criteria for an axis ii obsessive - compulsive personality disorder ( evaluated by the structured clinical interview for dsm - iv axis ii personality disorders).25 twelve patients ( 37.5% ) received psychopharmacological treatment with selective serotonin reuptake inhibitors and/or atypical antipsychotics and/or mood modulators , while the remaining 20 subjects were medication - nave . the an - r clinical sample was compared to a healthy control group ( hc ) composed of 41 healthy female adolescents recruited from students ( mean age = 14.02  1.69 years ; range = 11.0817.16 years ) of a middle and a high school in the metropolitan area of pisa . the following established measures , which were part of a larger suite of tests , were administered for this study . the iri is a 28-item self - reported questionnaire that allows a multi - dimensional assessment of empathy , which can be measured by two cognitive subscales ( perspective taking [ pt ] ; fantasy [ fs ] ) and two affective subscales ( empathic concern [ ec ] ; personal distress [ pd ] ) . participants respond to each item using a 5-point likert scale ranging from 2  does not describe me well  to + 2  does describe me well  . therefore the scores of each subscale range between 14 and + 14 points where higher scores indicate more empathic abilities . to address eating disorder severity , the following measures were considered : 1 ) the body mass index ( bmi ) calculated by dividing body weight in kilograms by height in meters squared ( kg / m ) ; 2 ) the eating attitudes test ( eat-26),27 a 26-item self - reported questionnaire of disordered eating patterns . the total score ranges from 0 to 78 ; a higher score reflects a greater degree of eating pathology , with a score over 20 indicating a possible eating problem ; 3 ) disease duration , defined as the time interval between the onset of the first eating disorder symptoms and the administration of the tests . to address psychopathological traits associated with the eating disorder , two questionnaires were used : 1 ) the child behavior checklist ( cbcl 618),28 a 118 item parent - reported measure designed to record the problem behaviors as well as the competencies of children or adolescents . each item describes a specific behavior and the parent is asked to rate its frequency on a 3-point likert scale . the scoring gives a summary profile including internalizing ( int ) , external - izing ( ext ) , and total problems ( tp ) , and a syndrome profile ( withdrawn , anxious / depressed , somatic complaints , social problems , thought problems , attention problems , delinquent behavior , and aggressive behavior ) ; 2 ) the youth self report ( ysr 1118 ) , an118 items self - reported questionnaire for adolescents from 11 to 18 years old.28 the ysr provides a summary profile and a syndrome profile paralleling those of the cbcl 618 . the study was carried out according to the standards for good ethical practice of the irccs stella maris foundation , and was approved by the educational board of each school of the hc group . written informed consent from a parent or guardian of each patient was obtained . patients and their parents completed all the tests ( iri , eat-26 , cbcl 618 , and ysr 1118 ) during the first days of the clinical assessment . hc , in addition to the iri , completed the eat-26 and the ysr 1118 , in order to rule out subjects with eating problems and/or axis i psychopathology , respectively . in fact , the ysr has been found to show a significant correlation with clinical dsm - iv diagnoses.2830 thus , subjects with an eat-26 score > 20 , and/or a score > 60 on int and/or ext and/or tp at the ysr , were excluded from the study . hc data were collected by a physician resident in child and adolescent psychiatry ( pf ) during school hours and informed consent was obtained from participants and their parents through the head teacher s office at each school . the iri is a 28-item self - reported questionnaire that allows a multi - dimensional assessment of empathy , which can be measured by two cognitive subscales ( perspective taking [ pt ] ; fantasy [ fs ] ) and two affective subscales ( empathic concern [ ec ] ; personal distress [ pd ] ) . participants respond to each item using a 5-point likert scale ranging from 2  does not describe me well  to + 2  does describe me well  . therefore the scores of each subscale range between 14 and + 14 points where higher scores indicate more empathic abilities . to address eating disorder severity , the following measures were considered : 1 ) the body mass index ( bmi ) calculated by dividing body weight in kilograms by height in meters squared ( kg / m ) ; 2 ) the eating attitudes test ( eat-26),27 a 26-item self - reported questionnaire of disordered eating patterns . the total score ranges from 0 to 78 ; a higher score reflects a greater degree of eating pathology , with a score over 20 indicating a possible eating problem ; 3 ) disease duration , defined as the time interval between the onset of the first eating disorder symptoms and the administration of the tests . to address psychopathological traits associated with the eating disorder , two questionnaires were used : 1 ) the child behavior checklist ( cbcl 618),28 a 118 item parent - reported measure designed to record the problem behaviors as well as the competencies of children or adolescents . each item describes a specific behavior and the parent is asked to rate its frequency on a 3-point likert scale . the scoring gives a summary profile including internalizing ( int ) , external - izing ( ext ) , and total problems ( tp ) , and a syndrome profile ( withdrawn , anxious / depressed , somatic complaints , social problems , thought problems , attention problems , delinquent behavior , and aggressive behavior ) ; 2 ) the youth self report ( ysr 1118 ) , an118 items self - reported questionnaire for adolescents from 11 to 18 years old.28 the ysr provides a summary profile and a syndrome profile paralleling those of the cbcl 618 . the study was carried out according to the standards for good ethical practice of the irccs stella maris foundation , and was approved by the educational board of each school of the hc group . patients and their parents completed all the tests ( iri , eat-26 , cbcl 618 , and ysr 1118 ) during the first days of the clinical assessment . hc , in addition to the iri , completed the eat-26 and the ysr 1118 , in order to rule out subjects with eating problems and/or axis i psychopathology , respectively . in fact , the ysr has been found to show a significant correlation with clinical dsm - iv diagnoses.2830 thus , subjects with an eat-26 score > 20 , and/or a score > 60 on int and/or ext and/or tp at the ysr , were excluded from the study . hc data were collected by a physician resident in child and adolescent psychiatry ( pf ) during school hours and informed consent was obtained from participants and their parents through the head teacher s office at each school . a student s t - test was used to compare differences in eat-26 , ysr , and iri mean scores between an - r and hc groups ; multivariate analysis of variance ( anova ) with eat-26 and with int , ext , and tp mean scores of the ysr as a covariate was used to identify iri scales discriminating between an - r and hc groups ; spearman correlations were adopted to assess the relationship between iri scales and 1 ) associated psychopathology ( cbcl ) , and 2 ) eating disorder severity ( bmi and disease duration ) , respectively . all statistical analyses were performed using spss 18.0 for windows ( ibm corporation , armonk , ny , usa ) . independent t - test analysis indicated no significant differences between the an - r and the hc groups in age ( t=1.88 ; p=0.065 ) . the two groups showed significant differences between eat-26 ( t=8.47 ; p<0.001 ) and ysr ( int : t=4.96 ; p<0.001 ; ext : t=2.68 ; p=0.009 ; tp : t=3.78 ; p<0.001 ) scores . to examine the cognitive versus affective aspects of empathy , the total scores for the cognitive ( pt + fs ) scales and the affective ( ec + pd ) scales were calculated . as observed in figure 1 , an - r had a significantly lower ce mean score than hc ( an - r mean score : 0.44  6.87 ; hc mean score : 5.24  6.45 ; t = 3.0 ; p=0.003 ) . the an - r group scored significantly lower on both pt ( t = 2.36 ; p=0.021 ) and fs ( t = 2.18 ; p=0.032 ) scales . the two groups did nt show significant differences on ae mean score ( an - r mean score : 4.69  7.08 ; hc mean score : 4.20  4.75 ; t = 0.35 ; p=0.725 ) and the two related subscales ( see table 1 ) . significant differences between groups with respect to ce ( f=5.19 ; p=0.008 ) and the pt subscale ( f=3.70 ; p=0.03 ) when eat-26 mean scores were used as a covariate ; no significant differences on the fs subscale ( f=2.61 ; p=0.081 ) were obtained . significant differences between groups in iri when ysr mean scores were used as a covariate were noted . specifically , when int was used as a covariate : ce ( f=5.15 ; p=0.008 ) , pt ( f=2.41 ; p=0.098 ) , fs ( f=3.52 ; p=0.035 ) ; when ext was used as a covariate : ce ( f=5.08 ; p=0.009 ) , pt ( f=5.24 ; p=0.008 ) , fs ( f=2.29 ; p=0.109 ) ; when tp was used as a covariate : ce ( f=4.46 ; p=0.015 ) , pt ( f=2.92 ; p=0.061 ) , fs ( f=3.25 ; p=0.045 ) . no statistically significant associations between cognitive empathy and : 1 ) bmi ( rho=0.32 ; p=0.069 ) ; 2 ) disease duration ( rho=0.07 ; p=0.69 ) ; or 3 ) cbcl 618 ( int : rho=0.23 ; p=0.213 ; ext = 0.05 ; p=0.806 ; tp = 0.16 ; p=0.401 ) were detected . to examine the cognitive versus affective aspects of empathy , the total scores for the cognitive ( pt + fs ) scales and the affective ( ec + pd ) scales were calculated . as observed in figure 1 , an - r had a significantly lower ce mean score than hc ( an - r mean score : 0.44  6.87 ; hc mean score : 5.24  6.45 ; t = 3.0 ; p=0.003 ) . the an - r group scored significantly lower on both pt ( t = 2.36 ; p=0.021 ) and fs ( t = 2.18 ; p=0.032 ) scales . the two groups did nt show significant differences on ae mean score ( an - r mean score : 4.69  7.08 ; hc mean score : 4.20  4.75 ; t = 0.35 ; p=0.725 ) and the two related subscales ( see table 1 ) . significant differences between groups with respect to ce ( f=5.19 ; p=0.008 ) and the pt subscale ( f=3.70 ; p=0.03 ) when eat-26 mean scores were used as a covariate ; no significant differences on the fs subscale ( f=2.61 ; p=0.081 ) were obtained . significant differences between groups in iri when ysr mean scores were used as a covariate were noted . specifically , when int was used as a covariate : ce ( f=5.15 ; p=0.008 ) , pt ( f=2.41 ; p=0.098 ) , fs ( f=3.52 ; p=0.035 ) ; when ext was used as a covariate : ce ( f=5.08 ; p=0.009 ) , pt ( f=5.24 ; p=0.008 ) , fs ( f=2.29 ; p=0.109 ) ; when tp was used as a covariate : ce ( f=4.46 ; p=0.015 ) , pt ( f=2.92 ; p=0.061 ) , fs ( f=3.25 ; p=0.045 ) . no statistically significant associations between cognitive empathy and : 1 ) bmi ( rho=0.32 ; p=0.069 ) ; 2 ) disease duration ( rho=0.07 ; p=0.69 ) ; or 3 ) cbcl 618 ( int : rho=0.23 ; p=0.213 ; ext = 0.05 ; p=0.806 ; tp = 0.16 ; p=0.401 ) were detected . this study adds to the limited literature regarding empathy in an - r and the results show statistically significant differences between patients with an - r and the hc with respect to empathic profile assessed using the iri.4 the main finding arising from the current investigation , performed on a carefully selected population of adolescent females with an - r , is the impairment in empathic abilities limited to the cognitive domain , while sparing the affective component . cognitive capacity is the ability to take the perspective of the other person in real ( perspective taking scale ) and in fictional ( fantasy scale ) situations . in particular , a low score on the pt scale is indicative of an impairment in interpersonal functioning,4 and converges with the repeated findings of altered social skills in anorectic patients.6 moreover , since executive functions contribute to the effective development of ce31 and , at the same time , are consistently reported as impaired in an subjects,32 further research is warranted to clarify the possibility that executive functions deficits interfere with the reduced ce abilities of an patients . only two other studies assessed empathic abilities in an - r through the iri.33,34 in contrast with our results , these investigations reported no significant differences between patients and controls33 and higher ratings for emotional empathy in an subjects than hc participants.34 moreover , a mixed sample of both an - r and an - be patients were enrolled in this latter study , whereas in the current investigation subjects who engaged in binging / purging behaviors were excluded . hence , it is difficult to compare our work with the other two , as they do present substantial differences not only with respect to sample age ( adolescents in our report versus adults in guttman and laporte , and beadle et al)33,34 and clinical severity ( inpatients versus outpatients ) , but also as to the methods of score attribution . a lower ce and similar ae scores , compared to controls , is instead a finding that our an patients have commonalities with asperger subjects,17 providing further support for the similarities between the two disorders.7,8 results point out specific ce impairment in adolescents with an - r . in particular , this finding suggests three key issues : first , on the basis of its independence from associated psychopathology assessed through the ysr , a ce deficit could be considered a specific marker of the adolescent an - r , not mediated by comorbid symptoms ; second , the independence of a ce deficit from the severity of illness suggests that it is not directly attributable to the profound effects of starvation on neuropsychological functioning.35 in the future , longitudinal studies comparing ill and recovered an - r patients may clarify whether the reduction in ce is a state - correlated characteristic or if it also persists after recovery . third , the absence of correlation between ce scores and disease duration indicates the possible presence of a deficit in ce from the beginning of the disorder or even before an - r onset . the hypothesis of ce impairment as a precursor of an - r is consistent with other studies on the personality traits involved in creating a predisposition to developing this disorder.1,36 in this view , low ce could become one of the risk factors that precede the onset of a restrictive eating disorder . however , a prospective exploration of empathic skills in a non - clinical population is required to sustain the hypothesis of an association with the subsequent development of an . finally , empathic impairment limited to the cognitive domain supports its functional independence from the affective one ; neuroimaging ( for a review , see decety and meyer)37 as well as lesion studies5 sustain this hypothesis . in particular , two distinct brain systems for cognitive and ae have been described : the ventromedial prefrontal cortex is involved in ce , whereas the inferior frontal gyrus is a part of the ae network . interestingly , ventromedial prefrontal cortex anomalies have been frequently reported in neuroimaging studies conducted in an patients ( eg , uher et al);38,39 future functional mri research is needed to investigate the response to empathy - eliciting stimuli in an - r . the main result of this study is that adolescents with an - r type do not show global empathy abilities deficit , but rather a specific ce impairment . specifically , self - reported measurements lack of objectivity , can be biased by denial or exaggeration of symptoms , as well as social desirability , and only reflect the self - perception of empathic characteristics . however , this issue was mitigated in the present study by having a clinical psychologist remain with the subject in order to clarify possible misunderstandings during the administration of the iri scale . secondly , the control subjects were screened for possible axis i psychopathology through the ysr . however , besides the possible false positive and false negative results , the ysr does not evaluate personality disorders that could be present in the subjects enrolled in the study as controls . the vast majority ( 84.4% ) of an - r patients involved in this study also meet diagnostic criteria for an additional internalizing diagnosis assessed through the k - sads - pl.24 since internalizing disorders could impact empathic abilities,19 we can not rule out that the low levels of ce may be due to the influence of comorbid psychiatric symptoms rather than to an - r itself . also , while subjects with major depressive disorders assessed through the iri reported significantly lower levels of both cognitive and affective empathy,19 our an - r patients showed a selective impairment of ce . however , in order to investigate the specific role of internalizing symptoms on empathic abilities , future studies should include an additional control sample composed of depressed / anxious subjects matched for demographic characteristics . further , the selective inclusion criteria of the patient group imply a relatively small sample size that limits the statistical power of results . notwithstanding the problematic issues raised above , these data , if supported by a larger replication study , could have a 3-fold implications for an - r : a ) clinical , since the overall management of these patients should take into account the compromised empathic skills ; b ) therapeutic , with the development of specific intervention goals focused on ce enhancement ; and c ) preventive , with the aim of early individuation of subjects with ce deficits , a marker that , in addition to other susceptibility factors , may play an important role in the development and maintenance of the anorexic disorder .
backgrounda growing , but conflicting body of literature suggests altered empathic abilities in subjects with anorexia nervosa - restricting type ( an - r ) . 
 this study aims to characterize the cognitive and affective empathic profiles of adolescents with purely an-r.methodsas part of a standardized clinical and research protocol , the interpersonal reactivity index ( iri ) , a valid and reliable self - reported instrument to measure empathy , was administered to 32 female adolescents with an - r and in 41 healthy controls ( hc ) comparisons , matched for age and gender . 
 correlational analyses were performed to evaluate the links between empathy scores and psychopathological measures.resultspatients scored significantly lower than hc on cognitive empathy ( ce ) , while they did not differ from controls on affective empathy ( ae ) . 
 the deficit in ce was not related to either disease severity nor was it related to associated psychopathology.conclusionthese results , albeit preliminary , suggest that a dysfunctional pattern of ce capacity may be a stable trait of an - r that should be taken into account not only for the clinical management , but also in preventive and therapeutic intervention .