nhanes is conducted by the national center for health statistics of the centers for disease control and prevention . each 2-year survey includes a sample of the noninstitutionalized u.s . civilian population identified through a stratified multistage probability sampling design . detailed methods of the design and conduct of nhanes are available online ( 7 ) . the protocol for each nhanes was approved by the national center for health statistics of the centers for disease control and prevention institutional review board . informed consent was obtained from each participant . to provide stable estimates , we pooled data from the nhanes 20052006 , 20072008 , and 20092010 . we included adults 20 years of age or older who attended a morning study visit . because we were interested in identifying individuals whose only indication , per atp iii , for an ldl - c goal < 100 mg / dl was the presence of diabetes , we excluded individuals with a 10-year framingham chd risk score > 20% and those with a self - reported history of chd or stroke . data for other chd risk equivalents such as peripheral arterial disease and aortic aneurysm are not available in nhanes 20052010 and therefore are not included in this analysis . individuals who had not fasted for 9 h were missing lipid or glucose values , had triglycerides > 400 mg / dl , or who did not answer questions regarding the awareness and treatment of high cholesterol or the awareness of diabetes also were excluded . 1 ) . nhanes collects data through standardized procedures that include questionnaires , a medical examination , and phlebotomy . questionnaires are used to assess age , race / ethnicity , sex , education , annual household income , health insurance status , smoking status , family history of chd , personal history of chd or stroke , and a previous diagnosis of , and treatment for , high blood cholesterol and diabetes . additionally , participants were asked if their cholesterol had ever been checked , where and how recently they have obtained health care , and whether they had been tested for diabetes in the past 3 years . blood pressure was measured three times and height and weight were measured and used to calculate bmi . blood collection and processing plasma glucose , hemoglobin a1c , total cholesterol , hdl cholesterol ( hdl - c ) , and triglycerides were directly measured . participants were categorized based on diabetes status into one of four mutually exclusive categories as follows : 1 ) normal fasting glucose ; 2 ) impaired fasting glucose ; 3 ) undiagnosed diabetes ; and 4 ) diagnosed diabetes . based on guidelines from the american diabetes association ( 10 ) , diabetes was defined as a hemoglobin a1c 6.5% , fasting plasma glucose 126 mg / dl , or the use of antidiabetes medications in those who reported a history of diabetes . in individuals who reported a history of diabetes , the use of antidiabetes medications was determined by an affirmative response to at least one of the following questions :  are you now taking diabetic pills to lower your blood sugar ( these are sometimes called oral agents or oral hypoglycemic agents ) ?  or  are you now taking insulin ?  individuals who met the criteria for diabetes but answered  no  to the question  other than during pregnancy , have you ever been told by a doctor or health professional that you have diabetes or sugar diabetes ? impaired fasting glucose was defined as a hemoglobin a1c of 5.76.4% or fasting plasma glucose of 100125 mg / dl ( 10 ) . normal fasting glucose was defined as a hemoglobin a1c < 5.7% and a fasting plasma glucose < 100 mg / dl . all individuals who reported using cholesterol - lowering medications were considered to have high ldl - c . also , high ldl - c was defined based on the individual s global chd risk based on the 2004 update of the atp iii guidelines ( 11 ) and their ldl - c level as detailed in supplementary table 1 . we used a goal ldl - c of < 100 mg / dl for those with undiagnosed and diagnosed diabetes . those without diabetes who had two or more other chd risk factors and a framingham chd risk score of 1020% had an ldl - c goal of < 100 mg / dl . individuals without diabetes who had two or more chd risk factors and a framingham chd risk score of < 10% had an ldl - c goal of < 130 mg / dl . those with less than two chd risk factors had an ldl - c goal of < 160 mg / dl . chd risk factors used to determine global risk included older age ( 55 years or older for women and 45 years or older for men ) , current cigarette smoking , hypertension , family history of chd ( history of myocardial infarction or angina before age 50 years among first - degree relatives ) , low hdl - c ( < 40 mg / dl ) , or diabetes status . hdl - c 60 mg / dl is considered protective and offsets the presence of one these risk factors . awareness of high ldl - c was defined by an affirmative response to the question  have you ever been told by a doctor or other health professional that your blood cholesterol level was high ? use of lipid - lowering treatment was defined by affirmative responses to the following two questions :  to lower your cholesterol , have you ever been told by a doctor or other health professional to take prescribed medicine ?  and ldl - c control was defined based on the individual participant s global cardiovascular risk based on the 2004 update of the atp iii guidelines , as summarized in supplementary table 1 ( 11 ) . government insurance included medicare , medi - gap , medicaid , state children 's health insurance program , military health insurance , indian health service , or a state - sponsored health plan . hypertension was defined as mean systolic blood pressure 140 mmhg , mean diastolic blood pressure 90 mmhg , or a self - reported history of high blood pressure in an individual using medications for high blood pressure . estimated glomerular filtration rate was calculated using the chronic kidney disease epidemiology collaboration equation ( 12 ) . reduced estimated glomerular filtration rate was defined as levels < 60 ml / min/1.73 m. albuminuria was based on the random spot urine sample and was defined as levels 30 mg / g . we calculated descriptive statistics including mean ldl - c levels , the prevalence of high ldl - c , and awareness of high ldl - c by diabetes categories ( normal fasting glucose , impaired fasting glucose , undiagnosed diabetes , and diagnosed diabetes ) . next , we calculated the percent of each diabetes category who were treated among those with high ldl - c as well as among those aware of their high ldl - c . we then calculated the percent of each diabetes category in which ldl - c was controlled among those with high ldl - c as well as among those who were treated for high ldl - c . adults in 20052010 with high ldl - c , as well as the number who were aware of their high cholesterol , treated for high cholesterol , and had their ldl - c controlled . also , we calculated the number of u.s . adults with high ldl - c who were not aware of their diagnosis of high cholesterol , were aware but not treated , were treated but ldl - c was not controlled , and had controlled ldl - c . next , we used poisson regression models to calculate the prevalence ratios for having high ldl - c and awareness , treatment , and control of high ldl - c associated with undiagnosed versus diagnosed diabetes . initial models were unadjusted and age , sex , and race / ethnicity were adjusted . final regression models included adjustment for age , sex , race / ethnicity , income , education , insurance status , smoking status , bmi , hypertension , reduced estimated glomerular filtration rate , and albuminuria . data management was conducted using sas 9.2 ( sas institute , cary , nc ) and all analyses were performed using sudaan 10.1 ( research triangle institute , research triangle park , nc ) , accounting for the complex sampling design of nhanes . these weights adjust for the unequal probabilities of selection of participants , oversampling of certain populations , and participant nonresponse . nhanes sampling weights were recalibrated based on the proportion of participants missing data by 10-year age group , sex , and race / ethnicity . recalibration of the sampling weights corrects for differences in missing data across age , sex , and race / ethnicity strata , and assumes that data within strata are missing at random . nhanes is conducted by the national center for health statistics of the centers for disease control and prevention . each 2-year survey includes a sample of the noninstitutionalized u.s . civilian population identified through a stratified multistage probability sampling design . detailed methods of the design and conduct of nhanes are available online ( 7 ) . the protocol for each nhanes was approved by the national center for health statistics of the centers for disease control and prevention institutional review board . informed consent was obtained from each participant . to provide stable estimates , we pooled data from the nhanes 20052006 , 20072008 , and 20092010 . we included adults 20 years of age or older who attended a morning study visit . because we were interested in identifying individuals whose only indication , per atp iii , for an ldl - c goal < 100 mg / dl was the presence of diabetes , we excluded individuals with a 10-year framingham chd risk score > 20% and those with a self - reported history of chd or stroke . data for other chd risk equivalents such as peripheral arterial disease and aortic aneurysm are not available in nhanes 20052010 and therefore are not included in this analysis . individuals who had not fasted for 9 h were missing lipid or glucose values , had triglycerides > 400 mg / dl , or who did not answer questions regarding the awareness and treatment of high cholesterol or the awareness of diabetes also were excluded . nhanes collects data through standardized procedures that include questionnaires , a medical examination , and phlebotomy . questionnaires are used to assess age , race / ethnicity , sex , education , annual household income , health insurance status , smoking status , family history of chd , personal history of chd or stroke , and a previous diagnosis of , and treatment for , high blood cholesterol and diabetes . additionally , participants were asked if their cholesterol had ever been checked , where and how recently they have obtained health care , and whether they had been tested for diabetes in the past 3 years . blood pressure was measured three times and height and weight were measured and used to calculate bmi . blood collection and processing are detailed in the nhanes laboratory / medical technicians procedures manual ( 8) . plasma glucose , hemoglobin a1c , total cholesterol , hdl cholesterol ( hdl - c ) , and triglycerides were directly measured . participants were categorized based on diabetes status into one of four mutually exclusive categories as follows : 1 ) normal fasting glucose ; 2 ) impaired fasting glucose ; 3 ) undiagnosed diabetes ; and 4 ) diagnosed diabetes . based on guidelines from the american diabetes association ( 10 ) , diabetes was defined as a hemoglobin a1c 6.5% , fasting plasma glucose 126 mg / dl , or the use of antidiabetes medications in those who reported a history of diabetes . in individuals who reported a history of diabetes , the use of antidiabetes medications was determined by an affirmative response to at least one of the following questions :  are you now taking diabetic pills to lower your blood sugar ( these are sometimes called oral agents or oral hypoglycemic agents ) ?  or  are you now taking insulin ?  individuals who met the criteria for diabetes but answered  no  to the question  other than during pregnancy , have you ever been told by a doctor or health professional that you have diabetes or sugar diabetes ?  were considered to have undiagnosed diabetes . among individuals without diabetes , impaired fasting glucose was defined as a hemoglobin a1c of 5.76.4% or fasting plasma glucose of 100125 mg / dl ( 10 ) . normal fasting glucose was defined as a hemoglobin a1c < 5.7% and a fasting plasma glucose < 100 mg / dl . all individuals who reported using cholesterol - lowering medications were considered to have high ldl - c . also , high ldl - c was defined based on the individual s global chd risk based on the 2004 update of the atp iii guidelines ( 11 ) and their ldl - c level as detailed in supplementary table 1 . we used a goal ldl - c of < 100 mg / dl for those with undiagnosed and diagnosed diabetes . those without diabetes who had two or more other chd risk factors and a framingham chd risk score of 1020% had an ldl - c goal of < 100 mg / dl . individuals without diabetes who had two or more chd risk factors and a framingham chd risk score of < 10% had an ldl - c goal of < 130 mg / dl . those with less than two chd risk factors had an ldl - c goal of < 160 mg / dl . chd risk factors used to determine global risk included older age ( 55 years or older for women and 45 years or older for men ) , current cigarette smoking , hypertension , family history of chd ( history of myocardial infarction or angina before age 50 years among first - degree relatives ) , low hdl - c ( < 40 mg / dl ) , or diabetes status . hdl - c 60 mg / dl is considered protective and offsets the presence of one these risk factors . awareness of high ldl - c was defined by an affirmative response to the question  have you ever been told by a doctor or other health professional that your blood cholesterol level was high ? use of lipid - lowering treatment was defined by affirmative responses to the following two questions :  to lower your cholesterol , have you ever been told by a doctor or other health professional to take prescribed medicine ?  and ldl - c control was defined based on the individual participant s global cardiovascular risk based on the 2004 update of the atp iii guidelines , as summarized in supplementary table 1 ( 11 ) . government insurance included medicare , medi - gap , medicaid , state children 's health insurance program , military health insurance , indian health service , or a state - sponsored health plan . hypertension was defined as mean systolic blood pressure 140 mmhg , mean diastolic blood pressure 90 mmhg , or a self - reported history of high blood pressure in an individual using medications for high blood pressure . estimated glomerular filtration rate was calculated using the chronic kidney disease epidemiology collaboration equation ( 12 ) . reduced estimated glomerular filtration rate was defined as levels < 60 ml / min/1.73 m. albuminuria was based on the random spot urine sample and was defined as levels 30 mg / g . we calculated descriptive statistics including mean ldl - c levels , the prevalence of high ldl - c , and awareness of high ldl - c by diabetes categories ( normal fasting glucose , impaired fasting glucose , undiagnosed diabetes , and diagnosed diabetes ) . next , we calculated the percent of each diabetes category who were treated among those with high ldl - c as well as among those aware of their high ldl - c . we then calculated the percent of each diabetes category in which ldl - c was controlled among those with high ldl - c as well as among those who were treated for high ldl - c . adults in 20052010 with high ldl - c , as well as the number who were aware of their high cholesterol , treated for high cholesterol , and had their ldl - c controlled . also , we calculated the number of u.s . adults with high ldl - c who were not aware of their diagnosis of high cholesterol , were aware but not treated , were treated but ldl - c was not controlled , and had controlled ldl - c . next , we used poisson regression models to calculate the prevalence ratios for having high ldl - c and awareness , treatment , and control of high ldl - c associated with undiagnosed versus diagnosed diabetes . initial models were unadjusted and age , sex , and race / ethnicity were adjusted . final regression models included adjustment for age , sex , race / ethnicity , income , education , insurance status , smoking status , bmi , hypertension , reduced estimated glomerular filtration rate , and albuminuria . data management was conducted using sas 9.2 ( sas institute , cary , nc ) and all analyses were performed using sudaan 10.1 ( research triangle institute , research triangle park , nc ) , accounting for the complex sampling design of nhanes . these weights adjust for the unequal probabilities of selection of participants , oversampling of certain populations , and participant nonresponse . nhanes sampling weights were recalibrated based on the proportion of participants missing data by 10-year age group , sex , and race / ethnicity . recalibration of the sampling weights corrects for differences in missing data across age , sex , and race / ethnicity strata , and assumes that data within strata are missing at random . risk equivalents , 8% met criteria for diagnosed diabetes and 4% met criteria for undiagnosed diabetes . in general , those with undiagnosed diabetes were more similar to those with diagnosed diabetes than those with normal or impaired fasting glucose . although 89% of those with undiagnosed diabetes reported having a regular place for health care and 85% reported having received health care in the past year , only 67% reported being tested for diabetes in the past 3 years . those with undiagnosed diabetes had higher mean ldl - c than those with diagnosed diabetes overall and among those who were not being treated for high cholesterol ( table 1 ) . among those treated for high cholesterol , ldl - c levels were similar in subjects with undiagnosed and diagnosed diabetes . characteristics of nhanes participants without chd or chd risk equivalents other than diabetes by diabetes category , 20052010 the awareness , treatment , and control of high ldl - c are depicted in fig . individuals with undiagnosed diabetes had a similar prevalence of high ldl - c as those with diagnosed diabetes . however , those with undiagnosed diabetes were less likely to be aware of their high cholesterol compared with those with normal and impaired fasting glucose and diagnosed diabetes . they also were less likely to be treated for high cholesterol than those with diagnosed diabetes . among those with high ldl - c , ldl - c control was worse for those with undiagnosed diabetes than for those with either impaired fasting glucose or diagnosed diabetes . among those treated for high cholesterol , individuals with undiagnosed diabetes were equally as likely to have their ldl - c controlled as those with diagnosed diabetes but less likely to be at goal when compared with those with normal glucose or impaired fasting glucose . after multivariable adjustment , individuals with undiagnosed diabetes were less likely to be aware of their high ldl - c , be treated for high cholesterol , and among those with high ldl - c , were less likely to be controlled , relative to those with diagnosed diabetes ( table 2 ) . prevalence of high ldl - c and the awareness , treatment , and control of high ldl - c among u.s . adults without chd or chd risk equivalents other than diabetes by diabetes status , nhanes 20052010 . * p < 0.05 , with undiagnosed diabetes as referent . among all individuals with high ldl - c . among individuals aware of their diagnoses of high ldl - c . adults with undiagnosed diabetes compared to those with diagnosed diabetes in nhanes participants without chd or chd risk equivalents other than diabetes , 20052010 the number of u.s . adults with high ldl - c and the percent aware of , treated for , and with controlled ldl - c by diabetes status are depicted in fig . adults with undiagnosed diabetes and no history of chd or other chd risk equivalents . of these individuals , 59% were unaware of their high ldl - c , 13% were aware but not treated for high cholesterol , 12% were aware and treated but not at atp iii goals for high ldl - c , and 16% were aware of , treated for , and achieved ldl - c levels . in contrast , among those with diagnosed diabetes and no history of chd or other chd risk equivalents , only 28% were unaware of their high ldl - c , 10% were aware and not treated , 22% were aware and treated but it was not controlled , and 40% were aware , treated , and achieved goal ldl - c ( fig . adults with high ldl - c and the number who were aware of , treated for , and whose ldl - c was controlled among u.s . adults without chd or chd risk equivalents other than diabetes by diabetes status , nhanes 20052010 . in this analysis , we demonstrate that more than half of individuals with undiagnosed diabetes who do not have a history of chd or chd risk equivalents have high ldl - c . in addition , these data indicate that undiagnosed diabetes is associated with a lack of awareness of high cholesterol and lower likelihood of treatment and control compared with subjects with diagnosed diabetes . even after multivariable adjustment , those with undiagnosed diabetes were 36% less likely to be aware of having high ldl - c , 52% less likely to be treated for it , and 58% less likely to have their high ldl - c controlled to guideline - recommended levels when compared with those with diagnosed diabetes . adults with undiagnosed diabetes who did not have chd or other chd risk equivalents , only 16% had their ldl - c treated to atp iii goal . our findings are supported by at least one previous study that has documented individuals with undiagnosed diabetes and a high prevalence of uncontrolled cardiovascular risk factors . ( 13 ) studied the risk factor profiles of individuals with undiagnosed diabetes in nhanes from 1999 to 2008 . in their analyses , individuals with undiagnosed diabetes had a high prevalence of smoking , hypertension , and dyslipidemia . these analyses focused on variations by ethnicity but did not compare those with undiagnosed diabetes to those with diagnosed diabetes . furthermore , awareness , treatment , and control of ldl - c were not examined . our data extend these previous findings by demonstrating that individuals with undiagnosed diabetes are less aware of their high cholesterol and therefore are less likely to be treated for high cholesterol and , as a result , less likely to have their ldl - c controlled than those with diagnosed diabetes , despite similar risk factor profiles . the finding that individuals with undiagnosed diabetes have adverse risk factor profiles is clinically relevant because undiagnosed diabetes is common among individuals presenting with cardiovascular disease . in the atherosclerosis risk in communities study , in those with undiagnosed diabetes , higher hemoglobin a1c levels were associated with higher degrees of carotid intima - media thickness ( 14 ) . in addition , in a study from germany , 47% of individuals with diabetes presenting for elective coronary angiography were unaware of their diabetes diagnosis ( 15 ) . in a u.s . study , a total of 28% of individuals admitted to the hospital for acute coronary syndromes had undiagnosed diabetes ( 16 ) . unfortunately , despite being admitted to the hospital , 65% of these individuals were not recognized as having diabetes and were not treated as such ( 16 ) . undiagnosed diabetes also has been associated with increased mortality after cardiac surgery ( 17 ) . 5% had undiagnosed diabetes . compared with those with diagnosed diabetes or without diabetes , those with undiagnosed diabetes required more resuscitation , had higher rates of reintubation , had more ventilator days , and had higher perioperative mortality ( 17 ) . ( 17 ) , it would not be surprising if aggressive risk factor modification would reduce cardiovascular events in individuals with undiagnosed diabetes , assuming their diabetes was recognized and appropriate risk factor modification was initiated . one of the clearest implications for making a diagnosis of diabetes is that it would , per the atp iii guidelines , establish the presence of a chd risk equivalent ; in the absence of overt chd or the presence of other chd risk equivalents , this would lower the ldl - c treatment goal to < 100 mg / dl ( 3 ) . adults would have their ldl - c goal changed if their diabetes diagnoses were recognized . recent meta - analyses by chen et al . ( 18 ) and costa et al . ( 19 ) have demonstrated that statins significantly reduce cardiovascular events in individuals with diabetes . ( 20 ) and the cholesterol treatment trialists collaborators ( 21 ) strongly support aggressive lowering of ldl - c in individuals with diabetes . a previous study has suggested that identifying individuals with undiagnosed diabetes and instituting appropriate risk factor modification , including treatment of high ldl - c , would result in 510% absolute risk reduction in chd events over the course of 10 years ( 22 ) . given the millions of u.s . adults with undiagnosed diabetes , this absolute risk reduction means that hundreds of thousands of events could be averted . a disturbing observation in these data are that although 89% of those with undiagnosed diabetes report having a regular place for health care and 85% report having received health care in the past year , only 67% report being tested for diabetes in the past 3 years . this underscores the need to more aggressively identify individuals who are at risk for having diabetes and to appropriately screen these individuals . the failure to identify the diagnosis of diabetes , especially in this sample of u.s . adults with no history of chd and no other chd risk equivalents , represents an important missed opportunity to appropriately risk - stratify these individuals and aggressively lower their ldl - c to guideline - recommended levels . however , among those treated for high cholesterol , individuals with undiagnosed diabetes were as likely as those with diagnosed diabetes to have their ldl - c controlled , suggesting that , if identified , undiagnosed diabetes can be effectively treated . we relied on self - report to define chd , which may have resulted in the inclusion of some individuals with chd in our analysis . in addition , laboratory values for glucose and cholesterol were available from only a single point in time , potentially resulting in some misclassification of participants . we chose to exclude individuals with a self - reported history of chd or other chd risk equivalents , which limits generalizability of our findings to these populations . adults are not adequately classified according to atp iii recommendations solely on the basis of their undiagnosed diabetes . despite these limitations , these include its large population - based sample , the complex survey design that permitted the generation of nationally representative estimates , and the availability of fasting glucose and ldl - c measurements . in summary , undiagnosed diabetes is associated with lack of awareness , treatment , and control of high ldl - c . approximately 5 million u.s . these individuals may not be treated to achieve atp iii  defined ldl - c goals in large part as a result of the failure to make the diagnosis of diabetes . strategies to identify individuals at risk for having undiagnosed diabetes and screening these individuals are necessary to appropriately define and achieve atp iii ldl - c treatment targets in these individuals .
objectivediabetes is often undiagnosed , resulting in incorrect risk stratification for lipid - lowering therapy . 
 we conducted a cross - sectional analysis of the national health and nutrition examination survey ( nhanes ) 20052010 to determine the prevalence , awareness , treatment , and control of elevated ldl cholesterol ( ldl - c ) among u.s . 
 adults with undiagnosed diabetes.research design and methodsfasting nhanes participants 20 years of age or older who had 10-year framingham coronary heart disease ( chd ) risk scores < 20% and were free of chd or other chd risk equivalents ( n = 5,528 ) were categorized as having normal glucose , impaired fasting glucose , undiagnosed diabetes , or diagnosed diabetes . 
 high ldl - c was defined by the 2004 adult treatment panel ( atp ) iii guidelines.resultsthe prevalence of diagnosed and of undiagnosed diabetes was 8 and 4% , respectively . 
 mean ldl - c was 102  2 mg / dl among those with diagnosed diabetes and 117  3 mg / dl for those with undiagnosed diabetes ( p < 0.001 ) . 
 the prevalence of high ldl - c was similar among individuals with undiagnosed ( 81% ) and diagnosed ( 77% ) diabetes . among individuals with undiagnosed diabetes and high ldl - c , 
 38% were aware , 27% were treated , and 16% met the atp iii ldl - c goal for diabetes . 
 in contrast , among individuals with diagnosed diabetes and high ldl - c , 70% were aware , 61% were treated , and 36% met the atp iii goal . 
 subjects with undiagnosed diabetes remained less likely to have controlled ldl - c after multivariable adjustment ( prevalence ratio , 0.42 ; 95% ci , 0.230.80).conclusionsimproved screening for diabetes and reducing the prevalence of undiagnosed diabetes may identify individuals requiring more intensive ldl - c reduction .