the recent interest in minimal access surgery is based upon the theory that smaller surgical incisions lead to less postoperative pain , better cosmetic effects , less bleeding , shorter hospital stays , faster rehabilitation , and reduced cost . early results of minimally invasive aortic valve ( av ) surgery have been reported as promising by selected centers , with mortality rates of 0.8% to 4% , leading to increasing utilization of less invasive approaches for valve surgery throughout the world [ 1 - 8 ] . however , many surgeons remain skeptical about performing minimal access av replacement ( avr ) , as this technique results in limited exposure and difficulties in handling , making surgery more difficult and dangerous . therefore , we performed a propensity - matched comparison of early outcomes in patients who underwent minimally invasive aortic valve surgery with those who underwent conventional full sternotomy . from august 1997 to july 2010 , 838 patients underwent primary isolated aortic valve replacement by five surgeons . of these patients , 73 underwent surgery using minimally invasive approaches ( upper sternotomy in 51 , transverse sternotomy in 20 , right mini - thoracotomy in 1 , and lower sternotomy in 1 ) whereas 765 underwent surgery through full sternotomy . the choice of procedure depended on the preference of the surgeons . for upper sternotomy , percutaneous internal jugular cannulation was done in 51 patients ( 69.8% ) to facilitate venous drainage during cardiopulmonary bypass . a limited median skin incision ( range , 6 to 8 cm ) was made beginning at the sternal notch , and the upper partial sternotomy was made with the oscillating saw down to the fourth intercostal space , at which a transverse sternal osteotomy was made . the upper portion of the pericardium was divided , exposing the upper part of the pericardial structures . the right common femoral vein was exposed through a 3 to 4 cm incision after heparinization and was cannulated . the arterial cannulation was performed at the ascending aorta ( n=40 ) , right femoral artery ( n=9 ) , or right axillary artery ( n=2 ) depending on the presence of atheromatous lesions at the aorta or peripheral arteries . mild - to - moderate hypothermic ( range , 28 to 32 ) cardiopulmonary bypass was used and myocardial protection was achieved with cold or tepid blood cardioplegia . initially , the cardioplegic solution was administered antegradely via aortic root cannulation ( 52% ) or direct coronary cannulation ( 48% ) according to the presence of aortic regurgitation . maintenance of cardiac arrest thereafter was done by retrograde cardioplegic infusion through the coronary sinus or by direct infusion through a coronary ostium , intermittently . after opening the aorta , three traction sutures at the tip of each commissure were placed and suspended from the drapes under tension , elevating the valve for better exposure . after aortic declamping , one drainage tube was placed through a subxiphoid incision before weaning from cardiopulmonary bypass to avoid cardiac rupture during the tube insertion . intraoperative transesophageal echocardiography was used routinely for assessment of the cardiac function , evaluation of surgical results , and confirmation of the de - airing process . an 8 to 10 cm transverse incision was made transversely at the level of the third or fourth intercostal space . the rest of the operation was a fairly routine procedure as for any other minimal access aortic valve surgery . this procedure was performed with a 6 to 7 cm incision along the right anterior axillary line . the sternum was incised from the tip of the xiphoid process up to the second intercostal space . cannulation was performed according to the standard technique with the usual methods of myocardial protection . categorical variables are presented as frequencies and percentages , and continuous variables are expressed as means with standard deviations or medians with ranges . to reduce the effect of treatment selection bias and potential confounding , we performed adjustments for the differences in the baseline characteristics by use of propensity score matching . the propensity scores were estimated with multiple logistic regression analysis . prespecified covariates listed in table 1 were included for the calculation of propensity scores . for the development of the propensity score - matched pairs ( a 1:1 match ) , the data of the two groups were compared with the paired t - test or the wilcoxon signed rank test for continuous variables ( age , left ventricular ejection fraction , postoperative creatine kinase ( ck)-mb and troponin - i levels , endotracheal intubation duration , intensive care unit stay ; and the amount of bleeding or transfusion ) , and with the mcnemar test or marginal homogeneity test for categorical variables ( sex , infective endocarditis , aortic valve diagnosis , diabetes , low cardiac output syndrome , bleeding reoperation , cerebrovascular attack , pulmonary infection , requirement for dialysis , sternal infection , atrial fibrillation , and complete aortic valve [ av ] block ) . all reported p - values were two - sided , and a value of p<0.05 was considered statistically significant . from august 1997 to july 2010 , 838 patients underwent primary isolated aortic valve replacement by five surgeons . of these patients , 73 underwent surgery using minimally invasive approaches ( upper sternotomy in 51 , transverse sternotomy in 20 , right mini - thoracotomy in 1 , and lower sternotomy in 1 ) whereas 765 underwent surgery through full sternotomy . for upper sternotomy , percutaneous internal jugular cannulation was done in 51 patients ( 69.8% ) to facilitate venous drainage during cardiopulmonary bypass . a limited median skin incision ( range , 6 to 8 cm ) was made beginning at the sternal notch , and the upper partial sternotomy was made with the oscillating saw down to the fourth intercostal space , at which a transverse sternal osteotomy was made . the upper portion of the pericardium was divided , exposing the upper part of the pericardial structures . the right common femoral vein was exposed through a 3 to 4 cm incision after heparinization and was cannulated . the arterial cannulation was performed at the ascending aorta ( n=40 ) , right femoral artery ( n=9 ) , or right axillary artery ( n=2 ) depending on the presence of atheromatous lesions at the aorta or peripheral arteries . mild - to - moderate hypothermic ( range , 28 to 32 ) cardiopulmonary bypass was used and myocardial protection was achieved with cold or tepid blood cardioplegia . initially , the cardioplegic solution was administered antegradely via aortic root cannulation ( 52% ) or direct coronary cannulation ( 48% ) according to the presence of aortic regurgitation . maintenance of cardiac arrest thereafter was done by retrograde cardioplegic infusion through the coronary sinus or by direct infusion through a coronary ostium , intermittently . after opening the aorta , three traction sutures at the tip of each commissure were placed and suspended from the drapes under tension , elevating the valve for better exposure . after aortic declamping , one drainage tube was placed through a subxiphoid incision before weaning from cardiopulmonary bypass to avoid cardiac rupture during the tube insertion . intraoperative transesophageal echocardiography was used routinely for assessment of the cardiac function , evaluation of surgical results , and confirmation of the de - airing process . an 8 to 10 cm transverse incision was made transversely at the level of the third or fourth intercostal space . the rest of the operation was a fairly routine procedure as for any other minimal access aortic valve surgery . this procedure was performed with a 6 to 7 cm incision along the right anterior axillary line . the sternum was incised from the tip of the xiphoid process up to the second intercostal space . cannulation was performed according to the standard technique with the usual methods of myocardial protection . for upper sternotomy , percutaneous internal jugular cannulation was done in 51 patients ( 69.8% ) to facilitate venous drainage during cardiopulmonary bypass . a limited median skin incision ( range , 6 to 8 cm ) was made beginning at the sternal notch , and the upper partial sternotomy was made with the oscillating saw down to the fourth intercostal space , at which a transverse sternal osteotomy was made . the upper portion of the pericardium was divided , exposing the upper part of the pericardial structures . the right common femoral vein was exposed through a 3 to 4 cm incision after heparinization and was cannulated . the arterial cannulation was performed at the ascending aorta ( n=40 ) , right femoral artery ( n=9 ) , or right axillary artery ( n=2 ) depending on the presence of atheromatous lesions at the aorta or peripheral arteries . mild - to - moderate hypothermic ( range , 28 to 32 ) cardiopulmonary bypass was used and myocardial protection was achieved with cold or tepid blood cardioplegia . initially , the cardioplegic solution was administered antegradely via aortic root cannulation ( 52% ) or direct coronary cannulation ( 48% ) according to the presence of aortic regurgitation . maintenance of cardiac arrest thereafter was done by retrograde cardioplegic infusion through the coronary sinus or by direct infusion through a coronary ostium , intermittently . after opening the aorta , three traction sutures at the tip of each commissure were placed and suspended from the drapes under tension , elevating the valve for better exposure . after aortic declamping , one drainage tube was placed through a subxiphoid incision before weaning from cardiopulmonary bypass to avoid cardiac rupture during the tube insertion . intraoperative transesophageal echocardiography was used routinely for assessment of the cardiac function , evaluation of surgical results , and confirmation of the de - airing process . an 8 to 10 cm transverse incision was made transversely at the level of the third or fourth intercostal space . the rest of the operation was a fairly routine procedure as for any other minimal access aortic valve surgery . this procedure was performed with a 6 to 7 cm incision along the right anterior axillary line . the sternum was incised from the tip of the xiphoid process up to the second intercostal space . cannulation was performed according to the standard technique with the usual methods of myocardial protection . categorical variables are presented as frequencies and percentages , and continuous variables are expressed as means with standard deviations or medians with ranges . to reduce the effect of treatment selection bias and potential confounding , we performed adjustments for the differences in the baseline characteristics by use of propensity score matching . the propensity scores were estimated with multiple logistic regression analysis . prespecified covariates listed in table 1 were included for the calculation of propensity scores . for the development of the propensity score - matched pairs ( a 1:1 match ) , the greedy 5-to-1 digit matching algorithm was used . after propensity score matching , the data of the two groups were compared with the paired t - test or the wilcoxon signed rank test for continuous variables ( age , left ventricular ejection fraction , postoperative creatine kinase ( ck)-mb and troponin - i levels , endotracheal intubation duration , intensive care unit stay ; and the amount of bleeding or transfusion ) , and with the mcnemar test or marginal homogeneity test for categorical variables ( sex , infective endocarditis , aortic valve diagnosis , diabetes , low cardiac output syndrome , bleeding reoperation , cerebrovascular attack , pulmonary infection , requirement for dialysis , sternal infection , atrial fibrillation , and complete aortic valve [ av ] block ) . all reported p - values were two - sided , and a value of p<0.05 was considered statistically significant . 9.1 ( sas institute inc . , cary , nc , usa ) , was used for statistical analyses . propensity score matching yielded 73 matched pairs of patients in which there were no significant differences in baseline characteristics between the minimally invasive approach group ( mias group ) and conventional sternotomy group ( conv group ) . aortic clamping time was slightly longer with the mias group ( 106.345.3 minutes vs. 101.939.6 minutes , p=0.06 ) whereas cardiopulmonary bypass time was equivalent between the two groups ( 106.345.3 minutes vs. 101.939.6 minutes , p=0.53 ) . in the mias group , conversion to full sternotomy was needed in 2 patients ( 2.7% ) due to operation site bleeding . there were no significant differences between the mias group and the conv groups in the rate of postoperative complications including low cardiac output syndrome , reoperation due to bleeding , cerebrovascular accident ( cva ) , pulmonary infection , acute renal failure requiring dialysis , and wound infection . ck - mb and troponin t levels measured at 6 hours postoperatively were similar in both groups ( table 3 ) . there were no significant differences in the duration of endotracheal intubation or intensive care unit stay , the amount of bleeding or amount of transfusion during the first 24 hours , or the rate of postoperative atrial fibrillation or complete av block between the two groups ( table 3 ) . postoperative echocardiography performed within 7 days of surgery revealed similar left ventricular ejection fraction in the two groups ( 59.69.3% in the mias group and 56.912.5% in the conv group , p=0.15 ) . patients in the mias group showed a higher pao2/fio2 ratio at the time of admission to the intensive care unit ( 333145 in the mias group and 248133 in the conv group , p<0.001 ) and less pain during hospitalization ( pain score , 3.791.67 in the mias group and 4.321.56 in the conv group ; p=0.04 ) than did those in the conv group . the present study demonstrated that minimally invasive approaches were associated with similar levels of hospital morbidity and mortality to conventional sternotomy . the points of controversy are whether minimally invasive av surgery can provide good exposure for surgeons and beneficial results for patients . this is partly related to the fact that since the total anterior mediastinum is not dissected in the upper sternotomy approach , the heart can be located in a relatively anterior position . the exposure of the aortic root can be enhanced by three traction sutures at the tip of each of the three commissures that will eventually lift up the valve . at the beginning of minimally invasive av surgery , several different methods of gaining access to the surgical field have been reported and different techniques regarding great vessel cannulation , aortic cross - clamp , and de - airing have been proposed [ 3 - 5,11 - 13 ] . because aortic atherosclerosis is correlated with the increased incidence of aortic valve sclerosis , cannulation into the femoral artery using longer cannulae for minimally invasive approaches carries the potential risk of direct aortic injury , aortic dissection , atherothromboembolism , and acute limb ischemia . we routinely evaluated the quality of the descending aorta and peripheral arteries by preoperative computed tomography scanning . the absence of peripheral vascular complications and the minimum risk of cva in the current study may be attributed to this approach . this study and other reports have shown no increase in the perioperative stroke rate associated with minimally invasive av surgery . intraoperative transesophageal echocardiography was performed for the detection of residual air in the left ventricle before the release of the aortic cross - clamp and weaning from cardio - pulmonary bypass . flooding the thoracic cavity with carbon dioxide gas decreases the danger of air embolism . the application of all these modalities is thought to minimize the risk of neurologic complications . the damage to the intrathoracic artery may have a great influence upon the recovery from a sternotomy wound   and can affect the prognosis of patients who are potential candidates for coronary artery bypass grafting in the future . since the extent of surgical trauma is considerably lower with minimally invasive incisions , the pulmonary function can be better preserved because only a small portion of the entire sternum was cut off . the minimally invasive approach group tended to have a more favorable postoperative respiratory reserve , probably due to decreased chest wall instability and reduced postoperative pain . the increased sternal stability allowed patients to change position early and cough more efficiently . although conventional sternotomy , compared to other thoracic incisions , is a relatively less - painful incision , many patients still report considerable pain even long after surgery . in our survey of standard versus minimally invasive incisions we have routinely used intravenous fentanyl patient - controlled analgesia and oral non - steroid anti - inflammatory analgesics to control surgical site pain . patients who complained of severe pain , despite the use of the above - mentioned medications , were given oral opioid ( hydromorphone hcl ) or transdermal opioid ( fentanyl propanamide ) for pain relief . these treatments were adopted for most patients regardless of the surgical approach ( conventional or minimally invasive ) and might have contributed to less perceived pain , postoperatively . this study is subject to the limitations inherent in retrospective studies of observational data from a single center . the non - randomized design may have affected our results due to unmeasured confounders , procedure bias , or detection bias , even with the use of rigorous statistical adjustment . both minimally invasive approaches and conventional sternotomy had comparable early clinical outcomes in patients undergoing primary isolated avr .
backgroundthe aim of this study is to evaluate our institutional results of the aortic valve replacement through minimally invasive approaches compared with conventional sternotomy.materials and methodsfrom august 1997 to july 2010 , 838 patients underwent primary isolated aortic valve replacement . of them , 
 73 patients underwent surgery through minimally invasive approaches ( mias group ) whereas 765 patients underwent surgery through the conventional sternotomy ( conv group ) . 
 clinical outcomes were compared using a propensity score matching design.resultspropensity score matching yielded 73 pairs of patients in which there were no significant differences in baseline profiles between the two groups . 
 patients in the mias group had longer aortic cross clamp than those in the conv group ( 74.927.9 vs .. 66.227.3 , p=0.058 ) . in the mias group , 
 conversion to full sternotomy was needed in 2 patients ( 2.7% ) . 
 there were no significant differences in the rates of low cardiac output syndrome ( 4 vs. 8 , p=0.37 ) , reoperation due to bleeding ( 7 vs. 6 , p=0.77 ) , wound infection ( 2 vs. 4 , p=0.68 ) , or requirements for dialysis ( 2 vs. 1 , p=0.55 ) between the two groups . 
 postoperative pain was significantly less in the mias group than the conventional group ( pain score , 3.791.67 vs. 4.321.56 ; p=0.04).conclusionboth minimally invasive approaches and conventional sternotomy had comparable early clinical outcomes in patients undergoing primary isolated aortic valve replacement . 
 minimally invasive approaches significantly decrease postoperative pain .