current management options for localized prostate cancer include surgery , radical prostatectomy ( rp ) , radiotherapy , and active surveillance . radiotherapy is administered as either external - beam radiotherapy ( ebrt ) , interstitial brachytherapy , or a  combination of both . interstitial brachytherapy with permanent seed implantation for localized prostate cancer has rapidly gained popularity over the past decade in usa , europe , and asia . many reports with long term follow - ups are now available , which confirm good outcomes in selected patients with prostate specific antigen ( psa ) , relapse - free survival rates equivalent to those achieved by surgery [ 2 , 3 ] . however , the excellent results achieved with both low and high dose rate brachytherapy mostly come from single institutions in developed countries with significant experience in prostate brachytherapy [ 4 , 5 ] . setting up of a  prostate brachytherapy service requires expensive equipment   and well trained personnel ; therefore not surprisingly there have been relatively few reports from africa . the objective of this study is to report how capacity was built in a  local brachytherapy team in ghana through international collaboration as well as the clinical outcome and complications identified in the first 90 patients treated with a  median follow - up of 58 months . prostate specific antigen tests and trans - rectal ultrasound guided biopsy became widely available in ghana in 2000 . this resulted in a  rise in the number of patients being diagnosed with organ - confined disease . facilities for staging including radioisotope bone scan , computed tomography ( ct ) scan , and magnetic resonance imaging ( mri ) also became locally available . some patients travelled to south africa and europe because there was no prostate brachytherapy facility in west africa . as at 2008 , south africa was the only country in africa that had well established prostate brachytherapy centers . we contacted the management of a  brachytherapy company with a  branch in south africa with our prostate cancer data , which indicated a  potential market for brachytherapy in ghana . the company provided equipment and training ( proctoring by an experienced specialist ) , whilst the hospital committed itself to procuring the radioactive seeds . the first session of brachytherapy included proctoring by a  urologist , physicist , and a  computer specialist from the planning software provider . a  product specialist nurse also accompanied the team to train the nursing and other theatre staff . , our proctors stayed at home in their respective countries but were available for consultation online or by telephone in case we encountered any technical challenges . between june 2008 and february 2014 , 90 patients with clinically localized prostate cancer underwent trans - perineal interstitial low dose rate permanent prostate brachytherapy with i seeds at korle bu teaching hospital . all patients were selected for this procedure based on stage and prognostic criteria and international prostate symptom score after consultation with radiations oncologist and urologists . all patients were staged according to the american joint committee on cancer 6 edition clinical staging guidelines   using a  directed history , physical examination including digital rectal examination , bone scintigraphy following psa results , and histopathology information . where indicated , ct and/or mri was obtained to evaluate the local extent of disease and nodal status . patients were classified into low - risk group ( t1 - 2a , psa < 10.0 ng / ml , and gleason score  6 ) , intermediate - risk group ( t2b - c or psa of 10 - 20 ng / ml , or gleason score 7 ) , and high - risk group ( t3a or psa > 20 ng / ml , or gleason score 8 - 10 ) according to the national comprehensive cancer network ( nccn ) criteria . patients with multiple intermediate - risk adverse factors were included in the high - risk group . all high - risk group patients were treated with brachytherapy boost combined with ebrt . in the intermediate - risk group , patients with psa of 15 ng / ml or less , t1c-2a , gleason score 3 + 3 , and percent of biopsy positive cores of less than 50% were treated by seed implantation alone . patients with prostate size more than 60 cc received androgen deprivation therapy ( adt ) for 3 - 4 months to reduce prostate size prior to implantation . the adt comprised luteinizing hormone releasing hormone ( lhrh ) agonist alone or in combination with an antiandrogen . the local ethical committee approval was granted prior to the commencement of the brachytherapy program . radioiodine seeds were pre - ordered for each patient based on the size of the prostate and whether the implant was radical or boost . the real time prostate seed implant technique   was used with a  perineal template to guide needles into the prostate ( figure 1 ) . a  urethral catheter was placed as well as a  rectal probe connected to the ultrasound . the recommended prescribed dose was 160 gy for a  full implant , and 110 gy for the boost . the planning system was used to obtain the best isodose coverage with acceptable , urethral , and rectal doses . assessment of a  good dosimetry included the dose to 90% of the prostate ( d90 ) , the prostate volume receiving 100% and 150% of the prescribed dose ( v100 and v150 respectively . upon approval by all members of the team , needles were placed within the prostate and loaded with seeds based on the approved plan . adjustments during the procedure were based on real - time changes in seed positions and isodose coverage to optimize dosimetry . the patient was discharged home within 24 - 48 hours after voiding without a  catheter . all patients received alpha - blockers just after seed implantation to relieve urinary symptoms for 3 - 6 months . real time brachytherapy session patients who received partial implant received additional pelvic irradiation starting 2 months after implant date . these patients are at high risk of extra - prostatic extension and developing lymph node metastases . doses delivered are between 39.6 - 50.4 gy in 20 - 28 fractions over 4 to 6 weeks using 3-dimensional conformal radiotherapy planning technique on co ebrt machine . the treated volume included the prostate gland , seminal vesicles , periprostatic tissues , and regional lymph nodes with a  0.8 to 1.0 cm margin , except posteriorly where the margin is 0.5 cm . the choice of prescribed dose depended on d80 , d100 , d90 to the prostate , and doses received by the rectum , urethra , and seminal vesicle with brachytherapy . the quality of the implant is assessed using a  ct scan performed a  month after the procedure . patients requiring subsequent external beam irradiation were planned to initiate treatments 12 weeks after seed implantation . subsequently , patients are monitored by symptom assessment , psa test , and physical examination every 3 - 6 months for the first 2 years and every 6 months thereafter . psa control was determined with respect to freedom from biochemical failure ( fbf ) , which was defined using the nadir + 2 ng / ml definition ( the phoenix definition ) . toxicity was defined as any symptom developing after implantation and scored by the common terminology criteria for adverse events ( ctcae ) , version 4.0 . urinary morbidity was assessed using the international prostate symptom score ( ipss ) before treatment and at 3 months , 6 months , and yearly after implantation . in addition , patients were asked whether or not they had erectile dysfunction , which was defined as the inability to achieve and/or maintain an erection sufficient for satisfactory sexual performance . kaplan - meier curves for fbf were generated for all patients based on risk category . univariate analysis was calculated using a  log - rank test to evaluate the association of risk factors with fbf . radioiodine seeds were pre - ordered for each patient based on the size of the prostate and whether the implant was radical or boost . the real time prostate seed implant technique   was used with a  perineal template to guide needles into the prostate ( figure 1 ) . a  urethral catheter was placed as well as a  rectal probe connected to the ultrasound . the recommended prescribed dose was 160 gy for a  full implant , and 110 gy for the boost . the planning system was used to obtain the best isodose coverage with acceptable , urethral , and rectal doses . assessment of a  good dosimetry included the dose to 90% of the prostate ( d90 ) , the prostate volume receiving 100% and 150% of the prescribed dose ( v100 and v150 respectively . upon approval by all members of the team , needles were placed within the prostate and loaded with seeds based on the approved plan . adjustments during the procedure were based on real - time changes in seed positions and isodose coverage to optimize dosimetry . the patient was discharged home within 24 - 48 hours after voiding without a  catheter . all patients received alpha - blockers just after seed implantation to relieve urinary symptoms for 3 - 6 months . real time brachytherapy session patients who received partial implant received additional pelvic irradiation starting 2 months after implant date . these patients are at high risk of extra - prostatic extension and developing lymph node metastases . doses delivered are between 39.6 - 50.4 gy in 20 - 28 fractions over 4 to 6 weeks using 3-dimensional conformal radiotherapy planning technique on co ebrt machine . the treated volume included the prostate gland , seminal vesicles , periprostatic tissues , and regional lymph nodes with a  0.8 to 1.0 cm margin , except posteriorly where the margin is 0.5 cm . the choice of prescribed dose depended on d80 , d100 , d90 to the prostate , and doses received by the rectum , urethra , and seminal vesicle with brachytherapy . the quality of the implant is assessed using a  ct scan performed a  month after the procedure . patients requiring subsequent external beam irradiation were planned to initiate treatments 12 weeks after seed implantation . subsequently , patients are monitored by symptom assessment , psa test , and physical examination every 3 - 6 months for the first 2 years and every 6 months thereafter . psa control was determined with respect to freedom from biochemical failure ( fbf ) , which was defined using the nadir + 2 ng / ml definition ( the phoenix definition ) . toxicity was defined as any symptom developing after implantation and scored by the common terminology criteria for adverse events ( ctcae ) , version 4.0 . urinary morbidity was assessed using the international prostate symptom score ( ipss ) before treatment and at 3 months , 6 months , and yearly after implantation . in addition , patients were asked whether or not they had erectile dysfunction , which was defined as the inability to achieve and/or maintain an erection sufficient for satisfactory sexual performance . kaplan - meier curves for fbf were generated for all patients based on risk category . univariate analysis was calculated using a  log - rank test to evaluate the association of risk factors with fbf . the median age of the cohort at the time of seed implantation was 64.0 years ( range 46 - 78 years ) . the median initial prostate - specific antigen level was 13 ng / ml ( range 2.1 to 133 ) , and the combined gleason score was 2 - 6 in 57 ( 52.3% ) , 7 in 26 ( 28.8% ) , and 8 - 10 in 7 ( 7.7% ) of the 90 study subjects . the clinical stage distribution was t1 in 28 ( 31.1% ) , t2 in 57 ( 51.3% ) , and t3 in 7 ( 7.7% ) of the patients ( table 1 ) . patient , cancer , treatment parameters , and freedom from biochemical failure ( fbf ) psa  prostate specific antigen , nccn  national comprehensive cancer network after a  median follow - up of 58 months ( range 19 - 84 ) , biochemical ( psa ) failure occurred in 12 ( 13.3% ) patients . the median time to biochemical failure was 36 months ( range 14 - 46 months ) . there were 4 deaths ( 6.4% ) , of which one was prostate cancer related . fbf rates for clinical stage t1 , t2 , and t3 were 96.4% , 85.9% , and 60% , respectively . with regards to nccn risk assessment , fbf for low , intermediate , and high - risk cases were 95.4% , 90.9% , and 70.8% , respectively . univariate analysis was performed to evaluate the association of clinical t stage , gleason score ( 2 to 6 , or 7 or 8 to 6 ) , psa group ( less than or equal to 10 ng / ml , more than 10 to 20 ng / ml , and greater than 20 ng / ml ) , and nccn risk assessment with fbf . clinical t stage ( p = 0.041 ) , gleason score ( p = 0.0038 ) , and nccn risk assessment ( p = 0.057 ) were prognostic for biochemical control . pre - treatment psa was an insignificant factor in predicting fbf ( p = 0.6 ) . freedom from biochemical failure ( fbf ) stratified by risk category ( a ) t stage , ( b ) gleason score , ( c ) pre - treatment psa , ( d ) nccn risk assessment urinary morbidity was common but minor . sixty - nine patients ( 76.6% ) experienced grade 1 and 2 urinary symptoms in the form of frequency , urgency , and poor stream . these symptoms were mostly self - limiting and occurred during the first two months after seed implantation . the ipss score increased in the first two months then decreased during the sixth month . acute urinary retention ( grade 2 ) occurred in 4 patients ( 4.4% ) within a  month after implantation . however , the other two failed to void without catheterization , which necessitated the insertion of a  suprapubic catheter and transurethral resection of the prostate ( grade 3 ) 9 months after seed insertion gastrointestinal ( gi ) toxicity in the form of grade 2 rectal bleeding occurred in 3 patients . one patient developed a  recto urethral fistula ( grade 3 ) following banding of suspected hemorrhoids by a  general surgeon 18 months after seed implantation . normal erectile function was reported in 74 men ( 82% ) prior to treatment . in patients with over 2 years follow - up , 62% reported good erection without the use of a  phosphodiesterase 5 inhibitor ( pd5i ) , 30% require phosphodiesterase 5 inhibitor for good erection , and 8% had no erection . after a  median follow - up of 58 months ( range 19 - 84 ) , biochemical ( psa ) failure occurred in 12 ( 13.3% ) patients . the median time to biochemical failure was 36 months ( range 14 - 46 months ) . there were 4 deaths ( 6.4% ) , of which one was prostate cancer related . fbf rates for clinical stage t1 , t2 , and t3 were 96.4% , 85.9% , and 60% , respectively . with regards to nccn risk assessment , fbf for low , intermediate , and high - risk cases were 95.4% , 90.9% , and 70.8% , respectively . univariate analysis was performed to evaluate the association of clinical t stage , gleason score ( 2 to 6 , or 7 or 8 to 6 ) , psa group ( less than or equal to 10 ng / ml , more than 10 to 20 ng / ml , and greater than 20 ng / ml ) , and nccn risk assessment with fbf . clinical t stage ( p = 0.041 ) , gleason score ( p = 0.0038 ) , and nccn risk assessment ( p = 0.057 ) were prognostic for biochemical control . pre - treatment psa was an insignificant factor in predicting fbf ( p = 0.6 ) . freedom from biochemical failure ( fbf ) stratified by risk category ( a ) t stage , ( b ) gleason score , ( c ) pre - treatment psa , ( d ) nccn risk assessment sixty - nine patients ( 76.6% ) experienced grade 1 and 2 urinary symptoms in the form of frequency , urgency , and poor stream . these symptoms were mostly self - limiting and occurred during the first two months after seed implantation . the ipss score increased in the first two months then decreased during the sixth month . acute urinary retention ( grade 2 ) occurred in 4 patients ( 4.4% ) within a  month after implantation . however , the other two failed to void without catheterization , which necessitated the insertion of a  suprapubic catheter and transurethral resection of the prostate ( grade 3 ) 9 months after seed insertion . gastrointestinal ( gi ) toxicity in the form of grade 2 rectal bleeding occurred in 3 patients . one patient developed a  recto urethral fistula ( grade 3 ) following banding of suspected hemorrhoids by a  general surgeon 18 months after seed implantation . normal erectile function was reported in 74 men ( 82% ) prior to treatment . in patients with over 2 years follow - up , 62% reported good erection without the use of a  phosphodiesterase 5 inhibitor ( pd5i ) , 30% require phosphodiesterase 5 inhibitor for good erection , and 8% had no erection . prostate cancer is the most commonly diagnosed malignancy in men and the second most common cause of male cancer death after liver cancer in ghana . ethnicity has a  great influence on prostate cancer incidence and mortality rates , with the black race having a  two - fold higher prostate cancer death rate than the white race , which in turn has a  two - fold higher incidence of prostate cancer death rate than the asian race . the incidence of prostate cancer has risen substantially in the past decade partly due to the introduction of psa based screening programs . as prostate cancer awareness increases , so does it screening , which in particular results in an increase of early - stage or localized disease [ 15 , 16 ] . for localized prostate cancer , these include radical prostatectomy , external beam radiotherapy , and prostate brachytherapy as low or high dose rate procedure . low dose rate permanent brachytherapy currently involves the use of i and pd radioisotopes , which deliver the intended dose over a  period of time depending on the dose rate of the isotope . high dose rate brachytherapy , on the other hand , involves the temporary use of ir , an isotope that is able to deliver the intended dose over a  shorter period of time . to date , no significant differences in outcome have been shown between these three treatment options in early stage disease [ 18 , 19 ] . high intermediate and high risk patients require a  combination of hormone deprivation therapy , and external beam with or without brachytherapy . besides tumor control , treatment morbidity is also an important endpoint that should be taken into account in the assessment of any treatment option . it is now generally accepted that post - treatment psa levels are the most sensitive means of assessing disease control and determining the efficacy of a  particular treatment . increasing prostate specific antigen ( psa ) levels after curative treatment is the first indicator of disease recurrence . biochemical failure is often used as a  reliable marker for treatment efficacy and prostate cancer survival . several studies have shown that the primary pre - treatment factors associated with psa control are pre - treatment psa , the gleason score , and the clinical stage [ 4 , 5 , 21 ] . this makes psa control comparisons across single - institution series problematic because case selection will have a  significant impact on the outcome of treatment . the proportion of high risk parameters in our study was much higher than that reported in most brachytherapy series . , on a  total of 2268 patients , which included 81% caucasians , 12% african americans ( aa ) , 6% hispanics , and 1% asians . ( p = 0.002 ) . similar to our findings , a  greater percentage of aa men presented with higher prostate - specific antigen levels ( psa ) ( > 10 ng / ml ; 44% vs. 21% ; p < 0.001 ) and had higher risk disease ( 24% vs. 15% ; p < 0.001 ) compared with caucasian men . despite these racial differences in pre - treatment parameters and biochemical disease recurrence , our results compare favorably with those reported by other institutions ( table 2 ) with greater brachytherapy experience . freedom from biochemical failure ( fbf ) of i low - dose - rate brachytherapy according to nccn risk assessment we think that two reasons might have contributed to the favorable results in our first cohort of patients . first , the equipment involved in the ldr brachytherapy procedure ( ultrasonography , perineal template , stepping unit , prostate needles , and treatment planning system ) improves the precision of the implant . secondly , we believe that the teaching , training and proctoring that our brachytherapy team received was of high quality . tumor control and survival rates for low - risk prostate cancer are comparable between the different treatment modalities . therefore , additional outcome measures and patient preferences should be evaluated prior to treatment selection . toxicity and quality of life have become important endpoints considered by most patients in the process of selecting a  treatment modality [ 25 , 26 , 27 ] . recent reports show that among the primary treatments for prostate cancer ( brachytherapy , radical prostatectomy , and external beam radiation therapy ebrt ) , brachytherapy has the least effect on over - all quality of life . our experience with these initial patients shows that most patients experience some degree of deterioration in lower urinary tract symptoms that may last for a  few weeks to months . this is a  consequence of the large dose delivered to the prostate in the first month , and the edema and hematoma caused by the trauma of the needles . the symptoms are generally mild and of short duration , but may be a  bother to patients who expect rapid recovery and return to pre - implant health . the predominant acute toxicity after prostate brachytherapy is urinary retention requiring catheterization , which occurred in 4% of our patients . published acute urinary retention ( aur ) rates vary from 1% to 34% [ 30 , 31 ] . patients pre - existing urinary obstructive symptoms are particularly prone to development of acute retention . rectal toxicity after prostate brachytherapy develops more often as a  late side effect , and occurs approximately one year after the procedure and persists for 1 to 2 years . grade 2 and 3 rectal toxicities have been reported to occur in 2 to 12% and 0.4 to 2% of patients , respectively [ 32 , 33 ] . additionally , patients who receive supplemental external beam boost are prone to develop rectal toxicity as a  result of telangiectasia [ 34 , 35 ] . this is consistent with our observation that all three patients who developed grade 2 rectal bleeding had received supplemental ebrt . recto urethral fistula , a  very distressing but rare toxicity , was observed in one patient ( 1% ) . the reported incidence of this complication is less than 0.1% [ 36 , 37 ] , and most cases occurred following rectal instrumentation or rectal biopsies after seed implantation   as occurred in our patient . the single patient who died of prostate cancer 4 years after seed implantation was probably under staged . very large series have reported a  5-year potency rates after prostatectomy , ebrt , and brachytherapy of 40% , 75% , and 80% , respectively , suggesting that brachytherapy may be the best option for prostate cancer treatment from a  sexual function quality - of - life viewpoint . our characterization of sexual function with the international index of erectile function ( iief 15 ) demonstrated that 62% patients who had undergone brachytherapy were able to preserve their potency . it is now generally accepted that post - treatment psa levels are the most sensitive means of assessing disease control and determining the efficacy of a  particular treatment . increasing prostate specific antigen ( psa ) levels after curative treatment is the first indicator of disease recurrence . biochemical failure is often used as a  reliable marker for treatment efficacy and prostate cancer survival . several studies have shown that the primary pre - treatment factors associated with psa control are pre - treatment psa , the gleason score , and the clinical stage [ 4 , 5 , 21 ] . this makes psa control comparisons across single - institution series problematic because case selection will have a  significant impact on the outcome of treatment . the proportion of high risk parameters in our study was much higher than that reported in most brachytherapy series . , on a  total of 2268 patients , which included 81% caucasians , 12% african americans ( aa ) , 6% hispanics , and 1% asians . ( p = 0.002 ) . similar to our findings , a  greater percentage of aa men presented with higher prostate - specific antigen levels ( psa ) ( > 10 ng / ml ; 44% vs. 21% ; p < 0.001 ) and had higher risk disease ( 24% vs. 15% ; p < 0.001 ) compared with caucasian men . despite these racial differences in pre - treatment parameters and biochemical disease recurrence , our results compare favorably with those reported by other institutions ( table 2 ) with greater brachytherapy experience . freedom from biochemical failure ( fbf ) of i low - dose - rate brachytherapy according to nccn risk assessment we think that two reasons might have contributed to the favorable results in our first cohort of patients . first , the equipment involved in the ldr brachytherapy procedure ( ultrasonography , perineal template , stepping unit , prostate needles , and treatment planning system ) improves the precision of the implant . secondly , we believe that the teaching , training and proctoring that our brachytherapy team received was of high quality . tumor control and survival rates for low - risk prostate cancer are comparable between the different treatment modalities . therefore , additional outcome measures and patient preferences should be evaluated prior to treatment selection . toxicity and quality of life have become important endpoints considered by most patients in the process of selecting a  treatment modality [ 25 , 26 , 27 ] . recent reports show that among the primary treatments for prostate cancer ( brachytherapy , radical prostatectomy , and external beam radiation therapy ebrt ) , brachytherapy has the least effect on over - all quality of life . our experience with these initial patients shows that most patients experience some degree of deterioration in lower urinary tract symptoms that may last for a  few weeks to months . this is a  consequence of the large dose delivered to the prostate in the first month , and the edema and hematoma caused by the trauma of the needles . the symptoms are generally mild and of short duration , but may be a  bother to patients who expect rapid recovery and return to pre - implant health . the predominant acute toxicity after prostate brachytherapy is urinary retention requiring catheterization , which occurred in 4% of our patients . published acute urinary retention ( aur ) rates vary from 1% to 34% [ 30 , 31 ] . patients pre - existing urinary obstructive symptoms are particularly prone to development of acute retention . rectal toxicity after prostate brachytherapy develops more often as a  late side effect , and occurs approximately one year after the procedure and persists for 1 to 2 years . grade 2 and 3 rectal toxicities have been reported to occur in 2 to 12% and 0.4 to 2% of patients , respectively [ 32 , 33 ] . additionally , patients who receive supplemental external beam boost are prone to develop rectal toxicity as a  result of telangiectasia [ 34 , 35 ] . this is consistent with our observation that all three patients who developed grade 2 rectal bleeding had received supplemental ebrt . recto urethral fistula , a  very distressing but rare toxicity , was observed in one patient ( 1% ) . the reported incidence of this complication is less than 0.1% [ 36 , 37 ] , and most cases occurred following rectal instrumentation or rectal biopsies after seed implantation   as occurred in our patient . the single patient who died of prostate cancer 4 years after seed implantation was probably under staged . very large series have reported a  5-year potency rates after prostatectomy , ebrt , and brachytherapy of 40% , 75% , and 80% , respectively , suggesting that brachytherapy may be the best option for prostate cancer treatment from a  sexual function quality - of - life viewpoint . our characterization of sexual function with the international index of erectile function ( iief 15 ) demonstrated that 62% patients who had undergone brachytherapy were able to preserve their potency . our results strongly support brachytherapy as a  highly effective treatment option for low , intermediate , and selected high - risk prostate cancer . our initial experience provides a  potential road map for the transfer of technology from developed countries to developing ones as it is difficult for practitioners from sub - saharan africa to acquire hands - on skill in complex surgical procedures in advanced countries . training in the practitioner s country with proctoring from experts is the ideal platform for rapid transfer of knowledge and skills . we expect that with the local availability of this treatment modality many more west african men with localized prostate cancer will undergo brachytherapy in the near future ; additionally , the local center may provide training opportunities for urologist and radiation oncologist in the sub region . limitations of this study include small patient numbers and short follow - up period .
purposethis study presents the experience of a  brachytherapy team in ghana with a  focus on technology transfer and outcome . 
 the team was initially proctored by experienced physicians from europe and south africa.material and methodsa  total of 90 consecutive patients underwent either brachytherapy alone or brachytherapy in combination with external beam radiotherapy for prostate carcinoma between july 2008 and february 2014 at korle bu teaching hospital , accra , ghana . 
 patients were classified as low - risk , intermediate , and high - risk according to the national comprehensive cancer network ( nccn ) criteria . 
 all low - risk and some intermediate risk group patients were treated with seed implantation alone . 
 some intermediate and all high - risk group patients received brachytherapy combined with external beam radiotherapy.resultsthe median patient age was 64.0 years ( range 46 - 78 years ) . 
 the median follow - up was 58 months ( range 18 - 74 months ) . 
 twelve patients experienced biochemical failure including one patient who had evidence of metastatic disease and died of prostate cancer . 
 freedom from biochemical failure rates for low , intermediate , and high - risk cases were 95.4% , 90.9% , and 70.8% , respectively . 
 clinical parameters predictive of biochemical outcome included : clinical stage , gleason score , and risk group . 
 pre - treatment prostate specific antigen ( psa ) was not a  statistically significant predictor of biochemical failure . 
 sixty - nine patients ( 76.6% ) experienced grade 1 urinary symptoms in the form of frequency , urgency , and poor stream . 
 these symptoms were mostly self - limiting . 
 four patients needed catheterization for urinary retention ( grade 2 ) . 
 one patient developed a  recto urethral fistula ( grade 3 ) following banding for hemorrhoids.conclusionsour results compare favorably with those reported by other institutions with more extensive experience . 
 we believe therefore that , interstitial permanent brachytherapy can be safely and effectively performed in a  resource challenged environment if adequate training and proctoring is provided .