suprachoroidal hemorrhages are a vision - threatening complication , and poor visual outcome is correlated with increasing hemorrhage complexity . the recommended time of surgical drainage is 1014 days after the hemorrhage begins to liquefy . we describe a case in which recombinant tissue plasminogen activator ( r - tpa ) , alteplase , is injected within the suprachoroidal space before surgery to assist in the drainage of an organized clot prior to liquefaction . this is a report of a technique in which r - tpa is used in the intrachoroidal space to target the organized clot of suprachoroidal hemorrhage prior to drainage . a 62-year - old male presented 12 days after retinal detachment repair with sudden ocular pain and vision loss after a valsalva maneuver . vision was light perception only , and intraocular pressure was 43 mmhg . diagnosed with hyphema and suprachoroidal hemorrhage , the patient underwent surgery the following day . an injection of r - tpa 100 g was given intracamerally , and an additional dose of r - tpa 100 g was injected into the suprachoroidal space prior to surgery to the author s knowledge , this is the first reported case in which r - tpa was successfully injected in the suprachoroidal space to liquefy and drain a suprachoroidal hemorrhage prior to natural dissolution . suprachoroidal hemorrhage is a vision - threatening complication associated with certain surgical procedures , such as cataract extraction , glaucoma filtering surgery , penetrating keratoplasty , and retinal detachment repair.14 suprachoroidal hemorrhage has also been reported to occur with penetrating trauma , choroidal melanoma , and may even occur spontaneously from corneal perforation secondary to infection.5 generally , suprachoroidal hemorrhage has a guarded prognosis and poor visual outcome is correlated with increasing hemorrhage complexity.6 in one study , only 35% of eyes had a final visual acuity of at least 5/200.6 visual rehabilitation is often limited and severe visual loss may be the final result . surgical drainage is a topic of much controversy , but may be advocated in cases where suprachoroidal hemorrhage is accompanied by retinal detachment , central choroidal apposition , retinal or vitreous incarceration in the surgical wound , persistent flat chamber , extreme pain , uncontrolled intraocular pressure , or inability to reposition intraocular contents.79 a suggested time for surgical drainage is said to be 1014 days when the hemorrhagic clot begins to liquefy.10 if adequate thrombolysis could be achieved earlier , retinal complications may be prevented or reduced . pharmacologic clearance of the clot could accelerate clearance of the hemorrhage and potentially reduce serious retinal complications . we describe the use of the recombinant tissue plasminogen activator ( r - tpa ) , alteplase , injected within the suprachoroidal space prior to surgery to assist in drainage of suprachoroidal hemorrhage . twelve days after surgery , the patient attended the clinic with severe eye pain and vision loss immediately after an episode of vomiting . at the time of examination , vision was light perception only and intraocular pressure was 43 mmhg . the patient had a dense anterior chamber hyphema and massive hemorrhagic choroidal detachment detected via b - scan ultrasonography . the patient was scheduled for surgical drainage the following day . at the beginning of surgery , r - tpa 100 g was injected into the anterior chamber and an additional r - tpa 100 g was injected into the suprachoroidal space . prior to performing conjunctival peritomy , approximately 45 minutes passed from the time of the initial injection of the r - tpa and actual drainage . liquified by the r - tpa , the previously organized clot was expressed through the sclerotomies . liquid perfluorocarbon was used to assist in the drainage process and flatten choroidals from within the eye . two air - fluid exchanges were performed , followed by an air - silicone exchange . best corrected vision in the eye eight months after the drainage procedure and three months after oil removal was 20/40 . poor outcome has been associated with retinal detachment at presentation , vitreous incarceration in the wound , and a 360 hemorrhage.6 as the complexity of the suprachoroidal hemorrhage increases , any associated retinal detachment is more difficult to fix.11 in addition , as the severity of the hemorrhage increases , it is associated with greater anatomic disruption , inflammation , and release of proliferative vitreoretinopathy precursor cells.11 hypotony is a significant problem and also appears to be associated with the degree of hemorrhage complexity , and may be due to hemorrhagic necrosis of the ciliary body.12 hypotony and increased ciliary body atrophy has been noted at 14 days in conjunction with hemorrhagic detachment of the ciliary body . indications for surgery may include marked retinal apposition due to massive choroidal detachment , involvement of the macular area by hemorrhage , retinal detachment , central choroidal apposition , retinal or vitreous incarceration in the wound , persistent flat chamber , extreme pain , and uncontrolled intraocular pressure.13 there is some disagreement as to when surgery should be performed . some authors suggest waiting 1014 days for the clot to liquefy prior to any surgical intervention , 10,14 whereas others advocate early surgical intervention for better anatomic and visual outcome.13 while waiting for the clot to liquefy , tractional retinal detachment may occur . where there is vitreous incarceration , waiting for spontaneous resolution could result in the formation of giant retinal tears and rhegmatogenous detachment secondary to traction on the incarcerated vitreous . in cases of extensive hemorrhage , patients have sustained vision loss from chronic atrophy or phtisis bulbi in the absence of prompt surgical intervention . as such , prompt drainage may provide the best chance for maintaining useful vision.15 however , when early drainage is performed , repeated surgical procedures are often necessary to drain the hemorrhage . r - tpa is a naturally occurring thrombolytic enzyme which activates fibrin - bound plasminogen to plasmin.16 when infused intravenously , the half - life of r - tpa is a few minutes . r - tpa has a high specific affinity for fibrin and enhances the binding of plasminogen to a fibrin clot . the enzyme acts selectively without inducing a systemic coagulation response.16 r - tpa has been effective in clearing hyphema , intraocular fibrin , vitreous hemorrhage , retinal vein occlusion , and subretinal hemorrhage.1720 in an experimental study involving rabbits , conducted by kwon et al , suprachoroidal hemorrhages were created in rabbit eyes and randomized for treatment with a surgical sponge soaked with r - tpa . clot dissolution started within minutes in the treated eyes , whereas days passed prior to the clot dissolving in the control eyes.21 another study , conducted by liu et al , evaluated the use of intravenous r - tpa in rabbits with suprachoroidal hemorrhages and found that intravenous r - tpa accelerated the clearance of the suprachoroidal hemorrhage when compared with control eyes.22 in our case , r - tpa 100 g was injected into the suprachoroidal space in the operating room prior to the surgery . another potential method for injecting r - tpa into the suprachoroidal space preoperatively is using b - scan ultrasonography to guide the injection . this procedure is easier with two people , ie , one person holds the ultrasound probe ( figure 1 ) , while the other performs the injection . the patient can then undergo the drainage procedure later that day or the following day . in the experimental setting , a suprachoroidal hemorrhage is treated with intravenous or subconjunctival r - tpa.21,22 systemic tissue plasminogen activator is associated with significant systemic risks including intracranial hemorrhage.23,24 directly targeting the clot with suprachoroidal r - tpa , as in this case report , would aid in early liquefaction and allow for easier expression of the hemorrhage through sclerotomies regardless of the time of drainage , with fewer systemic consequences . based on this case study , in which our patient had a fortunate outcome , it is our hypothesis that further study is warranted regarding the use of r - tpa in the treatment of suprachoroidal hemorrhage .
background : suprachoroidal hemorrhages are a vision - threatening complication , and poor visual outcome is correlated with increasing hemorrhage complexity . 
 the recommended time of surgical drainage is 1014 days after the hemorrhage begins to liquefy . 
 we describe a case in which recombinant tissue plasminogen activator ( r - tpa ) , alteplase , is injected within the suprachoroidal space before surgery to assist in the drainage of an organized clot prior to liquefaction . 
 this is a report of a technique in which r - tpa is used in the intrachoroidal space to target the organized clot of suprachoroidal hemorrhage prior to drainage.case report : a 62-year - old male presented 12 days after retinal detachment repair with sudden ocular pain and vision loss after a valsalva maneuver . 
 vision was light perception only , and intraocular pressure was 43 mmhg . diagnosed with hyphema and suprachoroidal hemorrhage , the patient underwent surgery the following day . an injection of r - tpa 100 g was given intracamerally , and an additional dose of r - tpa 100 g was injected into the suprachoroidal space prior to surgery . 
 liquified by r - tpa , the clot was expressed through the sclerotomies . 
 best corrected vision in the eye eight months after the drainage procedure was 20/40.conclusion : to the author s knowledge , this is the first reported case in which r - tpa was successfully injected in the suprachoroidal space to liquefy and drain a suprachoroidal hemorrhage prior to natural dissolution .