tamoxifen citrate ( tc ) was received as gratis sample from sun pharma pvt . ltd . all lipids compritol 888 ( glyceryl dibehenate ) , precirol ato 5 ( glyceryl disterate ) , gelucire 50/13 pellets ( stearoyl macrogol-32 glycerides ) , galeol pellets ( glyceryl monosterate ) were kindly gifted by gattefosse pvt . surfactants like lipoid s 75 - 3 , lipoid s pc-3 , phospholipon 80 h and phospholipon 90 was kindly gifted by lipoid ag , germany . tc loaded solid lipid nanoparticles were prepared by high shear homogenization followed by ultra sonication . lipid phase containing tc and the aqueous phase were heated to 70c , separately . the aqueous phase was poured into the lipid phase , with the stirring speed of 28,000 rpm for 10 minutes with heating using programmable digital homogenizer - pdh ( omni , usa ) . dispersion was ultrasonicated for 10 minutes to reduce the particle size and to avoid agglomeration of particles in the dispersion . quantity of tc was kept 0.1% . while drug : lipid ratio was kept 1:10 in the whole dispersion . particle size ( ps ) , particle size distribution - polydispersity index ( pdi ) and zeta potential of various batches were evaluated by zetasizer nano zs 90 ( malvern instruments ltd . ) . effect of type of lipid and concentration of surfactants are elaborated in tables 1 to 3 . cmpt.1 ( compritol 888 and 1% of tween 80 ) was found to be stable after 30 days according to ps and pdi analysis . effect of types of lipid and concentration of tween 80 on formulation effect of types of lipid and concentration of pluronic f-68 on formulation effect of types of lipid and concentration of pva on formulation tc loaded sln prepared by high shear homogenization followed by ultra sonication by using compritol 888 and tween 80 ( 1% ) showed good particle size , particle size distribution
tamoxifen citrate ( tc ) is an estrogen receptor antagonist and drug of choice for hormone sensitive breast cancer . 
 solid lipid nanoparticles loaded with tc were prepared by high shear homogenization followed by ultrasonication . 
 the aim of the present work is to study the effect of four different solid lipids and three surfactants on formulation and stability of sln . 
 they were characterized for particle size , polydispersity index and zeta potential by zetasizer nano . 
 sln prepared by solid lipid compritol 888 ( glyceryldibehenate ) and tween 80 ( 1% ) showed desired particle size of 206.9 nm , pdi of 0.046 and zeta potential of 9.32 mv .