malignant middle cerebral artery ( mca ) infarction ( mmi ) is a large hemispheric infarction due to the occlusion of the proximal middle cerebral artery or the internal carotid artery . mortality of mmi can be as high as 7080% with medical treatments mainly aimed at cerebral edema [ 2 - 5 ] . the surgical treatment for this type of stroke is hemicraniectomy , which removes a large bone flap on the side of the mmi and allows the infarcted brain tissue to bulge extracranially . recent clinical trials have clearly demonstrated benefits of hemicraniectomy in increasing survival rates [ 6 - 10 ] . however , 2040% of patients still die following hemicraniectomy due to refractory brain swelling [ 2,6 - 10 ] . mmi patients indicated for surgical decompression typically have decreased levels of consciousness [ 2 - 4,6 - 10 ] . space - occupying cerebral edema due to mmi can displace the infarcted hemisphere to the opposite side , resulting in an altered mental status . brain edema as manifested by lateral displacement of the brain , i.e. , midline shift , is an important cause of the decrease in consciousness and poor clinical outcomes in patients with mmi . however , it is unknown whether reduction in midline shift by hemicraniectomy can improve consciousness and survival in patients with mmi . herein , we aimed to investigate whether reduction of midline shift following hemicraniectomy is associated with improved consciousness and survival in patients with mmi . we considered stroke patients admitted to the neurological intensive care unit of asan medical center from january 2005 to august 2014 . patients were included in this study if 1 ) they were diagnosed as having ischemic stroke involving > 66% of the mca territory , as assessed by a computed tomography ( ct ) scan , and 2 ) if hemicraniectomy was performed . patients with additional infarctions in the anterior and/or posterior cerebral artery territories were not excluded , but those with parenchymal hematomas ( ph1 and ph2 ) on preoperative ct scan were excluded to rule out the effects of the hematoma and its evacuation on the midline shift . this study was approved by the institutional review board of asan medical center . the need for written informed consent we obtained data on demographics , risk factors , laboratory findings , the national institutes of health stroke scale ( nihss ) , and glasgow coma scale ( gcs ) from our stroke registry and medical records . the onset of stroke was considered to be the time when a patient was last known to be without ischemic symptoms . when a patient s symptoms were mild and the infarct size was initially small but progressed to a large hemispheric infarction , the onset of stroke was still considered to be the last - known time that the patient was normal . stroke subtypes were determined according to the classification of the trial of org 10172 in acute stroke treatment . survival status and the date of death were obtained from the national health insurance corporation . all patients with mmi were admitted to the neurological intensive care unit . the decision to perform hemicraniectomy was based on our protocol and discussions among neurologists , neurosurgeons , and the patients family members ( supplementary figure 1 ) . the surgery consisted of a large hemicraniectomy and a duroplasty at the side of the mmi . a large bony window was created by removing a bone flap in the frontal , parietal , temporal , and occipital regions ( supplementary figure 2 ) . the dura was opened and fixed at the margin of the craniotomy to prevent epidural bleeding . non - contrast ct was routinely performed after the surgery before or immediately after transfer to the neurological intensive care unit . perioperative medical treatments included general management , such as mechanical ventilation for patients with abnormal respiratory drives or reflexes , head elevation to 30 , avoidance of hypoxia and hyponatremia , and control of fever and hyperglycemia ; sedation and analgesia as indicated ; hyperventilation before urgent decompressive hemicraniectomy ; osmotherapy with mannitol or hypertonic saline ; and induced hypothermia and barbiturate coma therapy for patients with refractory brain swelling despite decompressive hemicraniectomy . all patients underwent neurological examinations , including gcs determination , every hour during their stay in the intensive care unit . non - contrast ct scans were routinely obtained on admission , immediately before hemicraniectomy , immediately after hemicraniectomy , upon neurological deterioration , at discharge from the intensive care unit , and at the discretion of the attending physician . for our study purposes , we used the findings of the last preoperative ct and the first postoperative ct . midline shift was determined using the distance from the midline to the septum pellucidum ( midline shift at the level of the septum pellucidum , sps ) and to the pineal gland ( midline shift at the level of the pineal gland , pgs ) . the reduction in midline shift ( sps and pgs ) in millimeters was defined as the amount ( mm ) of midline shift on the last preoperative ct minus that of the first postoperative ct . we used midline shift in millimeters for our analysis of midline shift , but we also categorized changes in midline shift as reductions ( reduction of 1 mm ) , no change ( -1 mm < reduction < 1 mm ) , and progression ( reduction of -1 mm ) for further analysis . the maximal size of the bone flap was measured between opposing hemicraniectomy edges on serial axial slices of post - hemicraniectomy cts . the bone flap size in this study was typically smaller than the maximal diameter of the same bone flap measured intraoperatively , as we did not measure the distance on the surface of the skull intra - operatively or using the skull radiograph , but measured this distance on ct post - operatively ( supplementary figure 3 ) . the extracranial bulging volume was measured as the volume of the brain tissue beyond the bony window , and the extracranial bulging ratio was defined as the ratio of the extracranial bulging volume to the maximal size of the bone flap ( figure 1 ) . the presence and maximal thickness of subgaleal hematomas were also evaluated . brain magnetic resonance imaging ( mri ) was routinely performed at the time of the initial diagnosis of stroke . the infarct volume was measured using diffusion - weighted imaging ( dwi ) as the sum of the infarct area in each slice multiplied by the slice thickness . we used a built - in calculation tool in the picture archiving and communication system ( pacs ; petavision , seoul , korea ) of the hospital for measurements of ct and mri findings . ct and mri variables were measured by investigators blind to our clinical data and patient outcomes . imaging findings were measured by two independent investigators ( s .- b .. j . and y .- j.k . ) and agreement was determined using intraclass correlation coefficients . we compared baseline characteristics and imaging variables according to the survival status of the patients at 180 days post - stroke . we used the pearson  test or fisher s exact test for categorical variables , student s t - test or mann - whitney u test for continuous variables , pearson coefficient for calculating correlations , and the jonckheere - terpstra test for ordered variables , as appropriate . variables with a p value < 0.1 by univariate analysis were included in a multivariate model as candidate variables and then removed using a backward stepwise selection procedure . preoperative ( sps and pgs ) and postoperative ( reduction of sps and pgs ) ct findings were also included in the multivariate models . survival curves were constructed using kaplan - meier estimates and were compared using the log - rank test . clinical and imaging variables were evaluated using cox proportional hazard analysis to identify predictors of survival . hazard ratios ( hrs ) with 95% confidence interval ( cis ) were also calculated . the discrimination ability and the contributions of sps and pgs to the prediction of survival at 180 days post - stroke all statistical analyses were performed using spss version 21 ( ibm corp . , armonk , ny , usa ) and sas version 9.1 ( sas institute inc . , cary , nc , usa ) . we considered stroke patients admitted to the neurological intensive care unit of asan medical center from january 2005 to august 2014 . patients were included in this study if 1 ) they were diagnosed as having ischemic stroke involving > 66% of the mca territory , as assessed by a computed tomography ( ct ) scan , and 2 ) if hemicraniectomy was performed . patients with additional infarctions in the anterior and/or posterior cerebral artery territories were not excluded , but those with parenchymal hematomas ( ph1 and ph2 ) on preoperative ct scan were excluded to rule out the effects of the hematoma and its evacuation on the midline shift . this study was approved by the institutional review board of asan medical center . the need for written informed consent we obtained data on demographics , risk factors , laboratory findings , the national institutes of health stroke scale ( nihss ) , and glasgow coma scale ( gcs ) from our stroke registry and medical records . the onset of stroke was considered to be the time when a patient was last known to be without ischemic symptoms . when a patient s symptoms were mild and the infarct size was initially small but progressed to a large hemispheric infarction , the onset of stroke was still considered to be the last - known time that the patient was normal . stroke subtypes were determined according to the classification of the trial of org 10172 in acute stroke treatment . survival status and the date of death were obtained from the national health insurance corporation . all patients with mmi were admitted to the neurological intensive care unit . the decision to perform hemicraniectomy was based on our protocol and discussions among neurologists , neurosurgeons , and the patients family members ( supplementary figure 1 ) . the surgery consisted of a large hemicraniectomy and a duroplasty at the side of the mmi . a large bony window was created by removing a bone flap in the frontal , parietal , temporal , and occipital regions ( supplementary figure 2 ) . the dura was opened and fixed at the margin of the craniotomy to prevent epidural bleeding . non - contrast ct was routinely performed after the surgery before or immediately after transfer to the neurological intensive care unit . perioperative medical treatments included general management , such as mechanical ventilation for patients with abnormal respiratory drives or reflexes , head elevation to 30 , avoidance of hypoxia and hyponatremia , and control of fever and hyperglycemia ; sedation and analgesia as indicated ; hyperventilation before urgent decompressive hemicraniectomy ; osmotherapy with mannitol or hypertonic saline ; and induced hypothermia and barbiturate coma therapy for patients with refractory brain swelling despite decompressive hemicraniectomy . all patients underwent neurological examinations , including gcs determination , every hour during their stay in the intensive care unit . non - contrast ct scans were routinely obtained on admission , immediately before hemicraniectomy , immediately after hemicraniectomy , upon neurological deterioration , at discharge from the intensive care unit , and at the discretion of the attending physician . for our study purposes , we used the findings of the last preoperative ct and the first postoperative ct . midline shift was determined using the distance from the midline to the septum pellucidum ( midline shift at the level of the septum pellucidum , sps ) and to the pineal gland ( midline shift at the level of the pineal gland , pgs ) . the reduction in midline shift ( sps and pgs ) in millimeters was defined as the amount ( mm ) of midline shift on the last preoperative ct minus that of the first postoperative ct . we used midline shift in millimeters for our analysis of midline shift , but we also categorized changes in midline shift as reductions ( reduction of 1 mm ) , no change ( -1 mm < reduction < 1 mm ) , and progression ( reduction of -1 mm ) for further analysis . the maximal size of the bone flap was measured between opposing hemicraniectomy edges on serial axial slices of post - hemicraniectomy cts . the bone flap size in this study was typically smaller than the maximal diameter of the same bone flap measured intraoperatively , as we did not measure the distance on the surface of the skull intra - operatively or using the skull radiograph , but measured this distance on ct post - operatively ( supplementary figure 3 ) . the extracranial bulging volume was measured as the volume of the brain tissue beyond the bony window , and the extracranial bulging ratio was defined as the ratio of the extracranial bulging volume to the maximal size of the bone flap ( figure 1 ) . brain magnetic resonance imaging ( mri ) was routinely performed at the time of the initial diagnosis of stroke . the infarct volume was measured using diffusion - weighted imaging ( dwi ) as the sum of the infarct area in each slice multiplied by the slice thickness . we used a built - in calculation tool in the picture archiving and communication system ( pacs ; petavision , seoul , korea ) of the hospital for measurements of ct and mri findings . ct and mri variables were measured by investigators blind to our clinical data and patient outcomes . imaging findings were measured by two independent investigators ( s .- b .. j . and y .- j.k . ) and agreement was determined using intraclass correlation coefficients . we compared baseline characteristics and imaging variables according to the survival status of the patients at 180 days post - stroke . we used the pearson  test or fisher s exact test for categorical variables , student s t - test or mann - whitney u test for continuous variables , pearson coefficient for calculating correlations , and the jonckheere - terpstra test for ordered variables , as appropriate . variables with a p value < 0.1 by univariate analysis were included in a multivariate model as candidate variables and then removed using a backward stepwise selection procedure . preoperative ( sps and pgs ) and postoperative ( reduction of sps and pgs ) ct findings were also included in the multivariate models . survival curves were constructed using kaplan - meier estimates and were compared using the log - rank test . clinical and imaging variables were evaluated using cox proportional hazard analysis to identify predictors of survival . hazard ratios ( hrs ) with 95% confidence interval ( cis ) were also calculated . the discrimination ability and the contributions of sps and pgs to the prediction of survival at 180 days post - stroke , armonk , ny , usa ) and sas version 9.1 ( sas institute inc . , cary , nc , usa ) . during the study period , 2,518 patients with ischemic stroke were admitted to our neurological intensive care unit . of these , 75 underwent hemicraniectomy for mmi . thus , 70 patients were included in the final analysis . of the 70 patients included in the study , 37 ( 52.9% ) the median patient age was 63 years ( range , 2281 years ; interquartile range [ iqr ] , 52.869.0 years ) . on admission , the median nihss was 15.5 ( iqr , 12.819.0 ) and the gcs total score was 10.0 ( iqr , 8.013.0 ) . at the time of surgery , the median gcs total score was 8.0 ( iqr , 7.011.0 ) . the median time from the last - known normal time to the skin incision under anesthesia was 41.6 hours ( iqr , 26.259.3 hours ) . the median time from the last preoperative ct to the first postoperative ct was 8.3 hours ( iqr , 6.110.2 hours ) . at 180 days post - stroke , 43 ( 61.4% ) of the patients were alive and 27 ( 38.6% ) were deceased . baseline characteristics , including demographics , risk factors , stroke classifications , vital signs , and laboratory findings , were not different between the surviving and the deceased patients , except that deceased patients were more likely to be females , have higher nihss scores , and have lower gcs scores ( table 1 ) . there were no statistically significant factors related to survival among the preoperative medical treatments , including thrombolysis , use of antithrombotic agents and statins , endotracheal intubation , mechanical ventilation , and osmotherapy . factors associated with the timing of the surgery ( workdays vs. holidays and daytime vs. nighttime ) and the operators were not related to survival . before surgery , brain mri was performed in 65 ( 92.9% ) patients , magnetic resonance angiography or ct angiography was performed in 65 patients , and non - contrast ct was performed in 70 patients . findings of the initial mri , the last preoperative ct , and the first postoperative ct are presented in table 1 . large infarct volumes as seen by dwi were associated with mortality at 180 days post - stroke . reductions in midline shift ( sps and pgs ) were significantly associated with higher levels of consciousness as measured by gcs at 24 hours post - operation and were marginally associated with an improvement of consciousness as measured by postoperative gcs minus preoperative gcs ( figure 2 , supplementary figure 4 ) . patients with reductions in midline shift ( both in millimeter units as measured and in categorized groups ) were more likely to survive at 180 days post - stroke than those with progression or no changes in midline shift ( p<0.001 ) ( table 1 , figure 3 ) . twenty - nine out of the 34 patients ( 85.3% ) with a reduction in sps , 10 out of the 19 patients ( 52.6% ) with no change in sps , and 4 out of the 17 patients ( 23.5% ) with a progression of sps were alive at 180 days post - stroke . twenty - three out of the 26 patients ( 88.5% ) with reductions in pgs , 17 out of the 31 patients ( 54.8% ) with no change in pgs , and 3 out of the 13 patients ( 23.1% ) with progression of pgs at the first postoperative ct were alive 180 days post - stroke . the intraclass correlation coefficient between the two ct raters was high ( 0.985 for sps , p<0.001 ; 0.991 for pgs , p<0.001 ; and 0.993 for extracranial bulging , p<0.001 ) . extracranial bulging volume was significantly related to the reduction in pgs ( categorical variable , p=0.030 ; continuous variable , p=0.021 ) and marginally related to the reduction in sps ( categorical variable , p=0.126 ; continuous variable , p=0.022 ) . the extracranial bulging ratio was also significantly related to the reduction in pgs ( categorical variable , p=0.010 ; continuous variable , p=0.007 ) and marginally related to the reduction in sps ( categorical variable , p=0.068 ; continuous variable , p=0.011 ) . however , infarct volume on dwi , skull size , bone flap size , subgaleal hematoma thickness , time interval from preoperative to postoperative ct , preoperative use of hyperosmotic agents , and preoperative mechanical ventilation were not related to changes in sps and pgs ( table 2 ) . after adjustment for sex , nihss , and preoperative sps , reduction in sps was associated with lower mortality 180 days post - stroke in the cox proportional hazards model ( adjusted hr , 0.71 ; 95% ci , 0.620.81 ; p<0.001 ) . reduction in pgs was also associated with lower mortality at 180 days post - stroke after adjustments for sex , nihss , and preoperative pgs ( adjusted hr , 0.76 ; 95% ci , 0.660.89 ; p<0.001 ) . we further analyzed these data with adjustments for age and sex , nihss , and preoperative midline shift , and found similar results ( table 3 , supplementary table 1 ) . of the 70 patients included in the study , 37 ( 52.9% ) were men . the median patient age was 63 years ( range , 2281 years ; interquartile range [ iqr ] , 52.869.0 years ) . on admission , the median nihss was 15.5 ( iqr , 12.819.0 ) and the gcs total score was 10.0 ( iqr , 8.013.0 ) . at the time of surgery , the median gcs total score was 8.0 ( iqr , 7.011.0 ) . the median time from the last - known normal time to the skin incision under anesthesia was 41.6 hours ( iqr , 26.259.3 hours ) . the median time from the last preoperative ct to the first postoperative ct was 8.3 hours ( iqr , 6.110.2 hours ) . at 180 days post - stroke , 43 ( 61.4% ) of the patients were alive and 27 ( 38.6% ) were deceased . baseline characteristics , including demographics , risk factors , stroke classifications , vital signs , and laboratory findings , were not different between the surviving and the deceased patients , except that deceased patients were more likely to be females , have higher nihss scores , and have lower gcs scores ( table 1 ) . there were no statistically significant factors related to survival among the preoperative medical treatments , including thrombolysis , use of antithrombotic agents and statins , endotracheal intubation , mechanical ventilation , and osmotherapy . factors associated with the timing of the surgery ( workdays vs. holidays and daytime vs. nighttime ) and the operators were not related to survival . before surgery , brain mri was performed in 65 ( 92.9% ) patients , magnetic resonance angiography or ct angiography was performed in 65 patients , and non - contrast ct was performed in 70 patients . findings of the initial mri , the last preoperative ct , and the first postoperative ct are presented in table 1 . large infarct volumes as seen by dwi were associated with mortality at 180 days post - stroke . reductions in midline shift ( sps and pgs ) were significantly associated with higher levels of consciousness as measured by gcs at 24 hours post - operation and were marginally associated with an improvement of consciousness as measured by postoperative gcs minus preoperative gcs ( figure 2 , supplementary figure 4 ) . patients with reductions in midline shift ( both in millimeter units as measured and in categorized groups ) were more likely to survive at 180 days post - stroke than those with progression or no changes in midline shift ( p<0.001 ) ( table 1 , figure 3 ) . twenty - nine out of the 34 patients ( 85.3% ) with a reduction in sps , 10 out of the 19 patients ( 52.6% ) with no change in sps , and 4 out of the 17 patients ( 23.5% ) with a progression of sps were alive at 180 days post - stroke . twenty - three out of the 26 patients ( 88.5% ) with reductions in pgs , 17 out of the 31 patients ( 54.8% ) with no change in pgs , and 3 out of the 13 patients ( 23.1% ) with progression of pgs at the first postoperative ct were alive 180 days post - stroke . the intraclass correlation coefficient between the two ct raters was high ( 0.985 for sps , p<0.001 ; 0.991 for pgs , p<0.001 ; and 0.993 for extracranial bulging , p<0.001 ) . extracranial bulging volume was significantly related to the reduction in pgs ( categorical variable , p=0.030 ; continuous variable , p=0.021 ) and marginally related to the reduction in sps ( categorical variable , p=0.126 ; continuous variable , p=0.022 ) . the extracranial bulging ratio was also significantly related to the reduction in pgs ( categorical variable , p=0.010 ; continuous variable , p=0.007 ) and marginally related to the reduction in sps ( categorical variable , p=0.068 ; continuous variable , p=0.011 ) . however , infarct volume on dwi , skull size , bone flap size , subgaleal hematoma thickness , time interval from preoperative to postoperative ct , preoperative use of hyperosmotic agents , and preoperative mechanical ventilation were not related to changes in sps and pgs ( table 2 ) . after adjustment for sex , nihss , and preoperative sps , reduction in sps was associated with lower mortality 180 days post - stroke in the cox proportional hazards model ( adjusted hr , 0.71 ; 95% ci , 0.620.81 ; p<0.001 ) . reduction in pgs was also associated with lower mortality at 180 days post - stroke after adjustments for sex , nihss , and preoperative pgs ( adjusted hr , 0.76 ; 95% ci , 0.660.89 ; p<0.001 ) . we further analyzed these data with adjustments for age and sex , nihss , and preoperative midline shift , and found similar results ( table 3 , supplementary table 1 ) . we analyzed the association between a reduction in midline shift following hemicraniectomy and the level of consciousness and six - month survival in 70 patients with mmi . the reduction of midline shift was evaluated a median of 0.4 hours after the operation and a median of 8.3 hours after preoperative ct . since such time intervals are short , we believe that the reduction in midline shift was driven mostly by the surgical decompression . a reduction in midline shift was associated with higher levels of postoperative consciousness . a reduction in midline shift was further related to survival : approximately 85% of the study patients with a reduced midline shift , 50% of patients with a stationary midline shift , and 20% of patients with a progressed midline shift survived at six months . thus , a reduction in midline shift may be a good indicator of the decompression effect of the hemicraniectomy and may be an early predictor of long - term survival in patients with mmi . midline shift has been correlated with the level of consciousness in patients with acute brain lesions . an early study of midline shifts reported a strong association between it and the development of stupor and coma in patients with acute intracerebral hemorrhages , subdural hematomas , epidural hematomas , and large mca infarctions . a recent study showed that a reversal of midline shift was related to awakening from coma in patients whose cause of brain edema was heterogeneous . previous studies of midline shift have primarily focused on the development of and recovery from unconsciousness during the acute stage of brain edema in heterogeneous populations using various treatment modalities . in the present study , the midline shift was caused by brain edema following acute ischemic stroke , and its reduction was an immediate effect of the surgical decompression . several radiological characteristics have been proposed as predictors of mortality in patients with mca infarctions , including large mca infarct volumes , the involvement of multiple vascular territories , occlusion of the internal cerebral artery , hyperdense mca signs on ct , m1 susceptibility vessel signs on gradient - echo imaging , large perfusion defects , and the absence of underlying brain atrophy [ 19 - 23 ] . such radiological characteristics predict a malignant course in patients who receive medical treatments . however , predictors of mortality after hemicraniectomy have not been clearly determined , although substantial proportions of patients still die of refractory brain swelling after hemicraniectomy . early predictors of survival may have clinical implications in triggering additional timely interventions [ 3 - 5 ] . given that refractory brain swelling is the main cause of death in patients with mmi , it is expected that patients who still expire despite hemicraniectomy would finally develop a prominent midline shift . in the present study , however , a reduction in midline shift was evaluated within one hour after a hemicraniectomy . thus , the reduction in midline shift was an immediate effect of the hemicraniectomy . to our knowledge , our study is the first to show that an immediate reduction of midline shift following a hemicraniectomy may be an early predictor of survival in mmi patients . in the present analysis , extracranial bulging was significantly related to the reduction of pgs and marginally related to the reduction of sps . unarguably , producing a large bony window by the removal of the bone flap may result in extracranial bulging of swollen brain tissue . the reduction in midline shift following hemicraniectomy may result from changing the direction of the brain displacement from the intracranial side to the extracranial side . however , massive extracranial bulging may be the result of severe brain swelling as well . thus , the efficacy of surgical decompression should be interpreted using the reduction in midline shift and not solely based on extracranial bulging . in addition to the inherent limitations of a retrospective design and selection bias , our study has other limitations of note . first , patient outcomes were defined as long - term survival and not as functional outcomes , which were not available for this retrospective study . however , the primary purpose of a hemicraniectomy is to save the life of a stroke victim . we do not believe that the mortality rate in our patients was driven by a self - fulfilling prophecy , as withdrawal of care was not allowed for local legal and cultural reasons . second , detailed operative factors were not obtained due to the retrospective nature of our analyses . the shape and size of the duroplasty , three - dimensional information regarding the bone flap such as surface area and the maximal length of the bone flap in the surgical field , resection of the temporalis muscle , and strokectomy were not analyzed . however the outcomes of a hemicraniectomy are more likely to be influenced by the last preoperative infarct volume than by the initial infarct volume . thus , we believe that additional data on final infarct volume would not have led to different findings . fourth , the mortality rate of our patients may have been affected by the retrospective design and selection bias . we included patients whose infarct size was initially small but progressed to a large hemispheric infarction . moreover , the patients in the earlier study period were enrolled before an early hemicraniectomy strategy , which was based on clinical trials and guidelines , was employed . fifth , assessment of the level of consciousness may have been affected by the use of sedative agents during the perioperative period . we showed that a reduction in midline shift following hemicraniectomy was associated with improved consciousness and survival in patients with mmi . our findings suggest that reductions in midline shift may be early indicators of effective decompression following hemicraniectomy . further studies are necessary to validate our findings and to explore their clinical implications with regard to triggering additional and timely interventions after a hemicraniectomy . mca indicates middle cerebral artery ; icp , intracranial pressure ; icu , intensive care unit ; ct , computed tomography . the blue line shows a question - mark - shaped skin incision line ( a ) . the skin , temporalis muscle , fascia , and periosteum are retracted after the incision . a large bony window was created by removing a bone flap in the frontal , parietal , temporal , and occipital regions . the green line is for the additional resection of parts of the temporal bone ( c ) . the dura was opened and fixed at the margin of the craniotomy to prevent epidural bleeding . the size of bone flap was determined using the longest distance between opposing hemicraniectomy edges on axial cuts of postoperative ct for a bone flap with an oval shape . blue parallel lines indicate lines connecting two opposing edges on serial axial cuts of post - hemicraniectomy ct , and the largest blue lines is marked in red . we used a red line ( a ) to indicate a bone flap size that is typically shorter than that measured intraoperatively ( b ) or on a skull radiograph ( c ) . gcs , glasgow coma scale ; sps , midline shift ( septum pellucidum shift ) ; pgs , midline shift ( pineal gland shift ) . factors associated with mortality at six months using multiple logistic regression analyses
background and purposehemicraniectomy is a decompressive surgery used to remove a large bone flap to allow edematous brain tissue to bulge extracranially . 
 however , early indicators of the decompressive effects of hemicraniectomy are unclear . 
 we investigated whether reduction of midline shift following hemicraniectomy is associated with improved consciousness and survival in patients with malignant middle cerebral artery infarctions.methodswe studied 70 patients with malignant middle cerebral artery infarctions ( mmi ) who underwent hemicraniectomies . 
 midline shift was measured preoperatively and postoperatively using computed tomography ( ct ) . 
 consciousness level was evaluated using the glasgow coma scale on postoperative day 1 . 
 patient survival was assessed six months after stroke onset.resultsthe median time interval between preoperative and postoperative ct was 8.3 hours ( interquartile range , 6.110.2 hours ) . 
 reduction in midline shift was associated with higher postoperative glasgow coma scale scores ( p<0.05 ) . 
 forty - three patients ( 61.4% ) were alive at six months after the stroke . 
 patients with reductions in midline shifts following hemicraniectomy were more likely to be alive at six months post - stroke than those without ( p<0.001 ) . 
 reduction of midline shift was associated with lower mortality at six months after stroke , after adjusting for age , sex , national institutes of health stroke scale score , and preoperative midline shift ( adjusted hazard ratio , 0.71 ; 95% confidence interval , 0.620.81 ; p<0.001).conclusionsreduction in midline shift following hemicraniectomy was associated with improved consciousness and six - month survival in patients with mmi . 
 hence , it may be an early indicator of effective decompression following hemicraniectomy .