the role of 2-deoxy-2-[f]fluoro - d - glucose positron emission tomography ( fdg - pet ) in the management of malignant brain tumors is uncertain . advocates of pet suggest that it has several roles complementary to those of magnetic resonance imaging ( mri ) and computed tomography ( ct ) in the evaluation of patients with primary or metastatic tumors of the brain [ 2 , 3 ] . these complementary roles reflect pet s unique ability to assess tissue glucose utilization , which facilitates evaluation of tumor grade , identification of optimal sites for stereotactic biopsy and determination of prognosis during the initial evaluation of patients with brain tumors . as a tool for evaluation following treatment , pet can also be useful for detecting residual tumor after surgery , distinguishing between radiation necrosis and recurrent tumor , and monitoring tumor progression . additionally , in patients with presumed metastatic lesions to the brain seen on mri , whole - body pet may be useful in determining the origin of unidentified primary tumors . since 2006 , the national oncologic pet registry ( nopr ) has collected data on medicare beneficiaries with known or suspected cancers undergoing pet for a wide variety of uncommon cancer types , including brain cancers , under centers of medicare and medicaid services policy called  coverage with evidence development  [ 57 ] . we have previously reported findings from nopr on the impact of whole - body pet on intended management in patients with proven or suspected cancer . we found that the effect of pet on changing intended management was highly consistent across cancer types and indications [ 8 , 9 ] . the objective of this study is to assess the impact of dedicated brain pet on intended patient management in patients with primary and metastatic brain tumors based on data in the nopr . the nopr is a prospective data registry that collects information from the pet facility , the physician requesting the pet scan , and the interpreting physician s pet report . detailed descriptions of nopr operations , human subject protection procedures , and results for the impact of pet on physicians intended management were reported previously [ 810 ] . in brief , the pet facility is responsible for collecting information from the referring physician on a pre - pet form and a post - pet form . the pre - pet form focuses on information regarding the specific indication for testing , the patient s cancer type ( if known ) and working stage assessment , the patient s performance status , whether the referring physician will also be the treating physician , and the referring physician s management plan if pet was not available . once the pet scan has been completed , the pet facility uploads the pet report to the database . the final step is the completion of the post - pet form by the referring physician to assess the management plan in light of the pet findings . the primary endpoint was the impact of pet on physicians intended management dichotomized as either treatment ( e.g. , surgery , chemotherapy , radiation , or other treatment , alone or in combination ) or non - treatment ( e.g. , observation , alternative imaging or other noninvasive testing , biopsy , or supportive care ) . a change in management was defined as a switch from treatment to non - treatment or vice versa . in december 2006 , the data collection procedures were changed to stratify the pet imaging procedures into three categories : body pet ( or pet / ct ) , dedicated brain pet only , or both body pet ( or pet / ct ) and dedicated brain pet . this analysis uses only cases of dedicated brain pet ( cpt code 78608 ) because where both body and dedicated brain imaging were performed , the referring physician s responses did not discriminate the impact of each component on intended management . the cohort does not include cases where a body pet or pet / ct acquisition ( cpt codes 7881178816 ) included the entire brain . in addition , cases where pet was requested for monitoring of ongoing treatment were excluded . statistical analysis a change in intended management after pet was modeled as binary variable on the basis of a binomial distribution . changes were defined at the pet scan level and were assumed to be independent for different patients or indication for testing.for the comparison of the change of intended management in the dedicated brain pet cohort with that in the overall nopr cohort ( excluding treatment monitoring ) , we used chi - square analysis . for these comparisons , we restricted our study population to those patients with primary brain tumors , excluding patients with proven or suspected brain metastases because of the small number of the latter . odds ratios ( ors ) were calculated to quantify the association between two binary variables . all statistical analyses were carried out using sas version 9.1 ( sas institute , cary , nc ) . this report includes data from 509 dedicated brain pet scans performed between december 1 , 2006 and april 3 , 2009 on 479 patients . during the same interval , additional four studies involving both body pet ( or pet / ct ) and dedicated brain pet were performed in two patients . the referring physicians recorded the cancer type as primary brain tumor ( n  =  367 ) and brain metastases ( n  =  142 ) , including suspected or proven brain metastases of unknown primary origin ( n  =  28 ) . the indication for pet imaging in patients with primary brain tumors was diagnosis in 21.2% , initial staging in 4.1% , restaging in 16.6% , and detection of suspected recurrence in 58.0% . thirty - seven cases , where the pre - pet form indicated that the patient had a primary brain tumor , were reclassified as suspected or proven brain metastases since the summary stage on the pre - pet form stated that the patient already had known non - brain metastatic sites . table  1profile of dedicated brain pet studies in noprprimary brain tumorsproven or suspected brain metastasisnumber%number%total scans ( total patients)367 ( 343)142 ( 139)age , mean ( years)61.867.9  median6670  range25972988primary site of metastases to brain  unknown primaryna2826.7  lung , small cellna1413.3  prostatena1211.4  kidney and other urinary tractna98.6  ovary and uterine adnexana65.7  otherna3634.performance status ( ecog scale )  asymptomatic : fully active ( 0)7620.73323.2  symptomatic , fully ambulatory ( 1)19653.47452.1  symptomatic in bed < 50% of the day ( 2)6016.32719.0  symptomatic in bed > 50% of the day ( 3)287.674.9  bedridden ( 4)71.910.7indication for pet  diagnosis7821.3  initial staging154.1  restaging6116.6  suspected recurrences21358.0pre - pet stage  no evidence of disease / remission174.632.1  localized only21859.41812.6  regional246.564.2  single site of metastasisna4531.6  multiple sites of metastasesna4028.1  unknown or uncertain10829.43021.1pre - pet intended management  observation256.81712.0  additional imaging12233.35438.0  tissue biopsy11531.33323.2  treatment10528.63826.8  curative4845.71847.4  palliative5754.32052.6na not applicable , ecog eastern cooperative oncology groupnot calculated because of reclassification of 37 cases ( see text ) profile of dedicated brain pet studies in nopr na not applicable , ecog eastern cooperative oncology group not calculated because of reclassification of 37 cases ( see text ) compared with the overall nopr cohort , subjects in the brain - only cohort were younger ( 41.3% less than 65  years vs. 10.5% overall , p  <  0.0001 ) and more often symptomatic from their cancers [ ecog ] performance score 1 in 78.6% vs. 62.3% overall ( or 2.2 , 95% ci 1.82.8 ) or 2 in 25.5% vs. 12.6% overall ( or 2.4 , 95% ci 1.92.9 ) . the pre - pet management plans in the primary brain tumor and metastasis subgroups were similar . the most frequent plan of intended management before pet , assuming pet was not available , was alternative imaging . for the primary tumor tumor - only subgroup , the pre - pet plan was slightly more frequently tissue biopsy than treatment ( 31.3% vs. 28.6% ) ; this frequency of planned biopsy if pet was not available was more common than in the overall nopr cohort ( 14.2% ; or 2.8 , 95% ci 2.23.5 ) . outcome results table  2 summarizes the changes in intended management when the pre- and post - pet plans were classified as treatment vs. non - treatment . the frequency of change in intended management associated with pet was 38.2% in the primary brain tumor subgroup and 35.2% in the brain metastasis subgroup . the frequency of change in the primary brain tumor subgroup was similar to that in the overall nopr cohort ( 37.0% ; or  =  1.1 , 95% ci 0.81.3 ) . table  2change in intended managementpre - petpost - petdiagnosis or initial stagingrestaging or suspected recurrenceknown or suspected brain metastasisprimary brain tumorsprimary brain tumors(n =  93)(n  =  274)(n  =  142)number%number%number%non - treatmentnon - treatment4851.612344.96847.9treatmenttreatment1111.84516.42416.9non - treatmenttreatment2223.76925.23625.4treatmentnon - treatment1212.93713.5149.9 in the primary brain tumor subgroup , there were modest differences when comparing scans done for diagnosis or initial staging ( n  =  93 ) vs. restaging or detection of suspected recurrence ( n  =  274 ) . any form of treatment as the post - pet plan was slightly more common in restaging / suspected recurrence cases ( 41.7% ) than in diagnosis / initial staging cases ( 35.5% ) . overall , changes from treatment to non - treatment were more frequent in the primary brain tumor subgroup than in the overall nopr cohort ( 13.4% vs. 7.7% ; or 1.9 , 95% ci 1.32.5).table  3 summarizes the changes in intended management when stratified by specific intended actions for the two brain tumor subgroups . for both subgroups , the two most frequent pre - pet strategies post - pet , the intended management was revised in more than 80% of cases to either observation or treatment . these revised post - pet plans were about equally divided between observation and treatment . table  3impact on intended management strategies associated with dedicated brain pet in nopr cohortchange from pre - pet to post - pet planprimary brain tumors ( n  =  367)known or suspected brain metastasis ( n  =  105)number%number%change from tissue biopsy to an alternative strategy98/11585.227/3381.8change from additional imaging to an alternative strategy105/12286.148/5488.9change from treatment to non - treatment49/10546.714/3836.8change from non - treatment to treatment91/26234.736/10434.6change in pre - pet treatment goal16/5628.65/2420.8for the primary brain tumor subgroup , a change in the pre - pet plan from treatment to non - treatment was more common ( 46.7% ) than the converse ( 34.7% ) . of the primary brain tumor patients with a pre - pet plan of treatment , change in intended management impact on intended management strategies associated with dedicated brain pet in nopr cohort dedicated brain pet for the evaluation of suspected or proven primary brain tumor or brain metastasis represents a narrow spectrum of the potential uses of pet in oncology . in part , this reflects the limited sensitivity of fdg imaging for detection of brain tumors , particularly those with low to moderate levels of fdg uptake , against a background of high fdg uptake in normal gray matter . mri , including newer perfusion and diffusion methods , has higher sensitivity and is the dominant modality for brain tumor imaging in current practice . nonetheless , pet provides complementary information on cancer metabolism that is correlated with tumor grade and prognosis at diagnosis and aids in detecting persistent or recurrent tumor after therapy . in this report , we describe the experience with oncologic brain pet among patients participating in the nopr . this report represents the largest series , to our knowledge , addressing the use and impact of dedicated brain pet in patients with brain tumors . our data indicate that dedicated brain pet is used relatively uncommonly for oncologic indications , accounting for only 0.67% of nopr pet scans . while only medicare beneficiaries were eligible for inclusion in this registry , over 40% of the patients were less than 65  years of age , the usual threshold for medicare eligibility . this is likely because younger participants with brain cancer already had qualified for disability ( and thus for medicare coverage ) as a consequence of their disease . that younger patients had to demonstrate disability to qualify for medicare coverage may explain the higher rates of functional impairment ( inferred from ecog performance scores ) observed in the dedicated brain pet cohort as opposed to the nopr population overall ( 79.3% vs. 64.3% , respectively ) . we found that the frequency of change in intended management associated with dedicated brain pet was similar to that found overall for the aggregate of other cancers in nopr , yet the changes in intended management as a consequence of pet were less frequently associated with the initiation of therapy in subjects with brain tumors . changes in intended management from treatment to non - treatment were more frequent than the converse . among patients with a pre - pet plan of tissue biopsy the avoidance of brain biopsy could result in significant cost savings , but further tracking of medicare claims is needed to evaluate if such savings are realized . a major limitation of the nopr is the inability to determine whether the intended changes in management confer a benefit in long - term outcomes . furthermore , the registry can not document that referring physicians actually completed the planned management changes . a data linkage to the medicare claims of nopr participants is in process to address this important question . although brain metastases outnumber primary neoplasms by at least ten to one , the use of dedicated brain pet in nopr to evaluate suspected metastases was infrequent and less common than for primary brain tumors . this suggests that referring physicians were highly selective in their use of dedicated brain pet among patients with metastatic cancer , which in turn may reflect the known relatively poor sensitivity of fdg - pet for detection of brain metastases [ 13 , 14 ] . still , in general the direction and magnitude of impact of pet on management was similar between groups . the estimated national incidence of primary brain cancers in the elderly ( age over 65  years ) is about 3,600 per year . the nopr patients are younger more often functionally impaired from their disease and rarely undergo a tissue biopsy after pet .
purposethis study seeks to assess the impact of dedicated brain positron emission tomography ( pet ) with 2-deoxy-2-[18f]fluoro - d - glucose on intended management of patients with primary and metastatic brain tumors.procedureswe analyzed demographic characteristics and evaluated change in intended management after pet , using previously described metrics , for patients in the national oncologic pet registry ( nopr ) undergoing dedicated brain pet . for cases of primary brain tumors , comparisons to the overall nopr cohort 
 were made.patient profilebetween december 2006 and april 2009 , 509 dedicated brain pet scans were done on 479 patients367 ( 72.1% ) for suspected or proven primary brain tumors and 142 ( 27.9% ) for brain metastases . compared with the overall nopr cohort , subjects in the dedicated brain cohort were younger ( 41.3% less than 65  years vs. 10.5% overall , p  <  0.0001 ) and more frequently had functional limitations from their cancers ( 78.6% vs. 62.3% overall ; odds ratio ( or ) 2.2 , 95% ci 1.82.8).resultsthe pre - pet patient management plans in the primary brain tumor and metastasis subgroups were similar . 
 a pre - pet plan of tissue biopsy was slightly more frequent than one of the treatments ( 31.3% vs. 28.6% ) in the primary brain tumor subgroup and was more common than in the overall nopr cohort ( 14.2% ; or 2.8 , 95% ci 2.23.5 ) . 
 changes from treatment to non - treatment also were more frequent than in the overall nopr cohort ( 13.4% vs. 7.7% ; or 1.9 , 95% ci 1.32.5).conclusionsamong nopr patients , dedicated brain pet was associated with similar net changes in intended management as in the overall nopr cohort . however , brain pet patients were younger , more likely to be symptomatic , and less likely to have a change in management from non - treatment to treatment as a post - pet plan .