in reviewing previous research , hernandez - reif et al . contend unequivocally that mt  has been shown to enhance immune functions  [ of ] children and speculate that this follows from mt 's effect on the stress hormone cortisol . quantitative reviews of mt randomized control trials do not yield statistically significant effects on cortisol levels of adults ( 4 ) [ effect size ( es ) = 0.14 , 95% confidence interval ( ci ) = 0.10 , 0.38 ] or children ( 5 ) ( es = 0.28 , 95% ci = 0.27 , 0.84 ) , nor on childrens immune functions ( 5 ) ( es = 0.06 , 95% ci = 0.52 , 0.63 ) . presumably , hernandez - reif et al . have scientifically grounded reasons to disagree with the results of those quantitative reviews . in that case , those reasons should be illustrated or at least mentioned in their section asserting mt effects on cortisol and immune functions . what should not happen is for mt effects that are contentious to be presented as well established . even a brief review of the results on which a current study is based should accurately represent the consensus , or lack thereof , among researchers . 's support for cortisol and immune function effects , and my own position that these effects are unestablished and possibly nonexistent , are primarily based on the same set of studies i am convinced that the cause of this discrepancy is what i discuss next ; specifically , that randomized control trials of mt are frequently analyzed and reported as if they were uncontrolled within - group studies , which consequently leads to misinterpretation of their results . in effect , they are randomized control trials in name only , and fail to properly utilize the well - established logic of randomization and experimental control . in discussing their results , the study authors state they have completed  the first randomized control trial to examine massage therapy for enhancing development and decreasing maladaptive behaviors in young dominican children infected with hiv, but this is not true , for the study is not a randomized control trial if it does not make between - groups comparisons of the dependent variables . the entire purpose of employing randomization to create treatment and control groups , as opposed to using a simpler within - group design , is so that one can make between - groups comparisons that control for the validity threats of spontaneous remission , placebo effects , and statistical regression . having performed analyses inconsistent with the study design , and that introduce rather than control these threats , the authors reach conclusions that are difficult to justify . to conclude that mt improved the behavior of the older sample of children , that it provided a  marginally significant increase in iq , or that it appears to be a viable therapy for promoting greater daily functioning and communication based on within - group analyses is misleading , because any or all of those pre post effects could be observed as a result of the aforementioned threats even if mt was wholly ineffective . further , those threats can not be controlled by the authors occasional use of what could be called  side - by - side within - group comparisons , in which they test each group separately for its own pre  post effect , and then give the impression that mt worked if it shows a statistically significant pre - post effect and the control group does not . this approach is not at all equivalent to making the required between - groups comparison , and the result is misleading , as it is easily possible in that situation ( especially with small samples ) to have only one of the two within - group comparisons be statistically significant when there is actually no difference between the groups . possibly the authors decision to exclude between - groups analyses of dependent variables was motivated by concern that the tests would be underpowered and therefore not attain statistical significance . however , even if this was the case , the small size and exploratory nature of the study can not be used to justify the decision to use within - group analyses . if problems pertaining to the statistical power of between - groups analyses were anticipated , there are defensible alternatives . these include choosing a more liberal value for alpha ( e.g. using p < 0.10 or p < 0.20 , rather than p < 0.05 ) , placing greater emphasis on effect sizes and their confidence intervals than on probability values , and examination of clinical significance ( 6 ) . simply stated , between - groups study designs such as randomized control trials logically demand between - groups analyses . until this is reflected in mt research , our knowledge of
the most recent massage therapy ( mt ) study by hernandez - reif et al . 
 displays flaws persistent in this area of research that are attributable to mt researchers frequent mistake of using within - group analyses of dependent variables in studies that are purported to be randomized control trials . 
 this practise violates the logic of using randomization to create treatment and control groups , and thereby fails to control for the validity threats of spontaneous remission , placebo effects , and statistical regression . 
 the result is that a clear understanding of what mt can and can not do is seriously hampered .