an amphiphilic nanoassembly was designed 
 to respond to the concurrent 
 presence of a protein and an enzyme . 
 we present herein a system , where 
 in the presence of these two stimuli supramolecular disassembly and 
 molecular release occur . 
 this molecular release arises in the form 
 a fluorescence response that has been shown to be specific . 
 we also 
 show that this system can be modified to respond only if light stimulus 
 is also present in addition to the protein and the enzyme . 
 demonstration 
 of such supramolecular disassembly principles could have broad implications 
 in a variety of biological applications .