viral and virally associated diseases show various head and neck manifestations.1 such pathologies may occasionally induce supraglottic mass lesions , resulting in an obstructive airway emergency.2 we herein report one such case in which a male immunocompromised patient with nephrotic syndrome due to membranous nephropathy ( mn ) and ophthalmic herpes zoster ( hz ) , a phenotype of hz that develops in patients presenting with the reactivation of latent varicella - zoster virus ( vzv ) in the ophthalmic division of the trigeminal nerve,36 developed a laryngeal mass that required urgent intubation and mechanical ventilation . the patient has given consent for publication of information and images in this report . a 63-year - old male patient whose condition was complicated by nephrotic syndrome presented with a five - day history of severe right periorbital edema with eruption of blisters over the ipsilateral forehead ( fig . nineteen months prior to his presentation , he was found to have the nephrotic syndrome due to biopsy - proven mn . he was then started on oral prednisolone ( psl ) at a dose of 50 mg / day , which was titrated thereafter at doses that ranged from 10 to 40 mg / day , depending on the context . ten months after the renal biopsy , oral cyclosporine a ( cya ; 100 mg / day ) was added to the therapeutic regimen . nonetheless , he never reached even a partial remission , and his nephrotic - range proteinuria of approximately 710 g / day persisted and his renal function steadily and progressively declined . oral psl ( 35 mg / day ) and cya ( 100 mg / day ) were therefore administered in combination with oral trimethoprim  sulfamethoxazole ( 160 mg of trimethoprim and 800 mg of sulfamethoxazole per week ) as antimicrobial prophylaxis during the last four weeks prior to the presentation . in this period , his peripheral lymphocyte counts were around 600800/l . a tzanck smear test of the vesicular lesions revealed multinucleated giant cells , while he also complained of a sore throat associated with odynophagia and burning pain in the right cervical area with an erythematous patch ( fig . he was subsequently admitted to our hospital for a further workup . at that time , physical examination revealed that he had anasarca , and his height was 167 cm and weight was 65.2 kg . laboratory examinations revealed the following results : white blood cell count , 15,700/l ( neutrophils , 92.3% ; lymphocytes , 1.1% ; monocytes , 4.6% ; eosinophils , 0.8% ; and basophils , 1.2% ) ; hemoglobin , 14.0 g / dl ; platelet count , 20  10/l ; blood urea nitrogen , 77 mg / dl ; creatinine ( cr ) , 4.23 mg / dl ; total protein , 4.6 g / dl , albumin ( alb ) , 2.5 g / dl ; c - reactive protein , 0.3 mg / dl ; immunoglobulin ( ig ) g , 311 mg / dl ; iga , 163 mg / dl ; and igm , 18 mg / day . within a few hours after admission , he gradually developed dyspnea with stridor . a computed tomography ( ct ) scan showed the presence of a supraglottic mass ( fig . 1c ) , while endoscopy revealed a right laryngeal space - occupying lesion involving the false vocal cord and aryepiglottic fold filling the right pyriform sinus , thereby causing almost complete airway obstruction . the patient was then intubated to secure his airway and placed on a mechanical ventilator . the administration of cya was stopped and tapering of psl was commenced , after which treatment with intravenous acyclovir ( acv ; 400 mg / day ) combined with broad - spectrum antibiotics was started empirically . the patient was also subjected to hemodialysis ( hd ) treatment three times a week to strictly control his volume status . the elevation of serum titers of both anti - vzv igm ( igm index 2.9 , cut - off index 0.8 ) and igg ( 3,400 iu / ml ) was confirmed on hospital day 6 after the patient s admission , at which time a cytomegalovirus ( cmv ) antigenemia ( cmv - ag ) assay with monoclonal antibodies c10/c11 revealed that the patient also had a cmv infection . the patient had an increased number of cmv - antigen - positive leukocytes ( 27/36 ) , a lymphocyte count of 400/l , and a cd4 t - lymphocyte count of 152/l . we then discontinued the administration of acv and gave priority to the simultaneous treatment of the cmv and vzv infections with intravenous ganciclovir ( gcv ; 1.29 mg / kg ) thrice a week ( fig . 2 ) , although this agent is not the first - line treatment for vzv - related disease.7 the patient was subsequently weaned from the ventilator by hospital day 10 when a serial ct scan revealed no signs of the supraglottic mass . on hospital day 24 , the cmv antigen assay became negative and the administration of gcv was terminated , as the cutaneous lesions around the orbital area subsided and the cervical erythema disappeared completely . around the same time , an arteriovenous fistula ( avf ) was created in the left forearm and the periodic hd program was continued . overall , the patient s clinical course was favorable , and the oral psl treatment was withdrawn approximately nine weeks after admission . at one - year follow - up , continued symptomatic management with pregabalin was required for persistent postherpetic neuralgia . hz is a neurocutaneous disease that results from the reactivation of latent vzv infection within the cranial or dorsal root ganglia.3 reactivation of dormant vzv is associated with the waning of cell - mediated immunity , either as a natural consequence of aging or as a result of immunosuppression.3,4 the fact that the deoxyribonucleic acid of vzv is detected in the trigeminal , cervical , thoracic , lumbar , and sacral dorsal root ganglia in autopsy studies implies that vzv remains latent in most sensory dorsal root ganglia.8 the segmental nature of hz may therefore depend on the vzv genome load distribution in different dorsal root ganglia , with the highest viral genome load leading to a characteristic dermatomal rash,9,10 while zoster may present in a multidermatomal fashion in some subsets of patients with an immunosuppressed status.5,10 obtaining the diagnosis of hzo in the current case was straightforward after confirming the characteristic manifestations , including a unilateral painful maculopapular rash with vesicles , crusting , ulceration , and erythematous edema on the forehead and periocular region.3,6 although one may argue that such a clinical picture may be too common to be described in the literature , the significance of our experience should be evaluated more carefully in terms of the concurrent development of a laryngeal mass that resulted in airway narrowing severe enough to require urgent intubation . although malignancy is the greatest concern in subjects presenting with neck masses,11 we believe that some inflammatory and/or infective processes , which may resolve with conservative treatment and in which the lesions are seldom removed or biopsied,12 may have played a role in the development of the disease in the current patient . laryngeal zoster , a phenotype of hz in the head and neck , includes a wide spectrum of manifestations , such as laryngeal mucosal eruptions , skin erythema , and multiple cranial nerve palsies.1317 vzv reactivation in the larynx may also mimic neoplasms by presenting with laryngeal masses,1820 and cases of laryngeal zoster without motor disorders or mucosal lesions are not exceptional.14,16,21 therefore , the laryngeal mass in the current patient can be attributed to a vzv - dependent mechanism , and it is thus not surprising that we failed to confirm any signs suggestive of laryngeal paresis , such as hoarseness or dysphagia , on the initial presentation , in addition to mucosal eruptions . considering the innervation of the laryngeal area , the concurrent vzv reactivation with vagus nerve involvement may have played a role,13,18,20 at least in part , in the establishment of the cervical manifestations in the current patient . despite the absence of a vesicular rash , the detection of a tender erythematous patch over the perilaryngeal skin , which did not accord with the dermatomal distribution in the cervical region , may be a subtype of a cutaneous manifestation of presumable vagal vzv mononeuritis , as described by wu et al.13 otherwise , one may argue that the involvement of a bacterial infectious process , such as paralaryngeal abscess formation , can not be excluded . alternatively , or in addition , we should need to focus on the concurrent cmv infection as another potential etiology for the disease . indeed , cases of cmv - associated laryngeal masses have been reported anecdotally.22,23 although the diagnostic impact of such a manifestation of cmv disease remains to be delineated , it has been previously stressed that invasive cmv infection in immunocompromised patients may start as a self - limited infection in the upper airway.22 our failure to perform surgical and histological assessments precludes us from pursuing the differential diagnosis for the neck mass thoroughly . nevertheless , it is reasonable to consider that these two viral infections could have additively or synergistically contributed to the prominent local pseudotumor . the prompt response of the tumor lesion to gcv that was observed in the current case strongly supports our proposal . however , this agent has been anecdotally shown to have a clinical benefit in the treatment for vzv infection.7 mn is one of the most common causes of nephrotic syndrome in adult subjects.24 the role of corticosteroids and various immunosuppressive agents as the basic treatment for this disease is still a matter of debate,2427 and it is thus not surprising that our patient finally progressed to end - stage renal failure along with a persistent nephrotic condition , despite the application of a therapeutic regimen consisting of psl and cya . this case may rather concern regarding how to deal with various types of steroids and immunosuppressants in patients with concurrent viral and/or bacterial infection . it has been shown that corticosteroids are beneficial and safe for a wide variety of infections,28 while the discontinuation and/or tapering of immunosuppressive regimens is an accepted option in this patient with active infections due to their immunosuppressive nature.29,30 the paucity of information regarding these points in nephrotic patients with mn complicated by hz and cmv infections implies that numerous decisions as to whether to continue immunosuppressive management are potentially empirical , as in the present patient . considering the diverse etiologies of an immunocompromised status,31 however , we are of the opinion that a careful analysis of all of the options and the risk of severe infections as well as disease severity on a case - by - case basis should be mandatory . needless to say , setting up an appropriate microbial diagnosis is another prerequisite as the list of potential microbial invaders in the immunocompromised milieu is broad , and antimicrobial strategies may differ according to the various clinical settings.32 finally , our experience stresses the importance of having a high index of suspicion , with prompt recognition and immediate intervention for obstructive airway emergencies caused by concurrently developing laryngeal masses , which can be associated with ophthalmic hz and cmv infection as diagnostic and therapeutic challenges beyond the field of nephrology , thereby reducing and preventing the incidence of morbidity of the disease .
several viral infections may occasionally induce supraglottic mass lesions , resulting in an obstructive airway emergency . 
 we herein report one such case in a 63-year - old male immunocompromised patient with nephrotic syndrome due to membranous nephropathy who also had ophthalmic herpes zoster with a laryngeal mass , which required urgent intubation and mechanical ventilation . 
 the patient was initially treated with acyclovir ; however , because a serological analysis revealed a concurrent cytomegalovirus infection , we discontinued the administration of acyclovir and gave priority to the simultaneous treatment of the cytomegalovirus and varicella - zoster virus infections with ganciclovir . 
 the clinical course was favorable , and he was weaned from the ventilator 10 days later when a serial imaging analysis revealed no signs of the supraglottic mass , leading us to conclude that these two viral infections could have additively or synergistically contributed to the development of the local pseudotumor . 
 the diagnostic and therapeutic concerns arising in the current case are also discussed .