treatment of hypertension , hyperlipidemia , and diabetes mellitus and assisting patients with cessation of cigarette smoking are efficacious in preventing firsttime and recurrent stroke . the opportunities to favorably influence blood pressure , cholesterol , and other vascular risk factors are substantial . the prevalence in the united states of persons with low riskfactor burden has been < 11% for decades . intensive medical therapy has been associated with a low absolute risk of stroke in patients with asymptomatic carotid stenosis . intensive statin therapy reduced the risk of any stroke by 33% in the > 1000 patients with known carotid disease in the stroke prevention by aggressive reduction in cholesterol levels ( sparcl ) trial . it is not known how well vascular risk factors are controlled in this population at risk for stroke . the carotid revascularization endarterectomy versus stenting trial ( crest ) is a multicenter randomized clinical trial of carotid stenting versus endarterectomy in patients with symptomatic and asymptomatic carotid disease . the purpose of this study was to assess whether the methods used in crest to manage vascular risk factors resulted in improvements in riskfactor status . the crest trial was approved by the local governing institutional review board of each participating center , and all patients provided written informed consent . the trial methods and primary results have been published . the investigational devices , the acculink / rx acculink carotid stent system and the accunet / rx accunet , were manufactured by abbott vascular , inc . the primary aim of the trial was to compare 2 types of revascularization procedures , carotid endarterectomy and carotid stenting ; however , the investigators recognized that monitoring and medical management of vascular risk factors were essential for patient safety and overall stroke risk reduction . patients underwent twiceyearly assessments of blood pressure , blood glucose , lipids , and cigarette smoking status for the first 48 months of the trial . the principal investigators and study coordinators at crest participating centers were instructed to inform the patients ' primary care physicians regarding the results of the vascularriskfactor assessments using a standardized letter . published american heart association guideline statements for levels of control of blood pressure , glucose in diabetic patients , and lipids were adopted studywide and were provided to the usualcare physician . the importance of appropriate concomitant medical therapy was emphasized at crest investigators and annual coordinators meetings throughout the course of the trial . studywide control of vascular risk factors was reported to and monitored by the independent data and safety monitoring board appointed by the national institute of neurological disorders and stroke . for this exploratory analysis , group means and rates for risk factors were calculated using generalized estimating equations ( using an unstructured covariance matrix ) to account for the differences in sample sizes at each followup visit while still accounting for the repeated measures for the same patient . in addition , rates were calculated for achieving key benchmarks of blood pressure , cholesterol , and glucose . to have a more sensitive marker of successful risk factor control , patients were considered to be optimally medically managed if they achieved all of the following therapeutic goals : lowdensity lipoprotein ( ldl ) cholesterol < 100 mg / dl , glucose < 126 mg / dl , systolic blood pressure < 140 mm hg , and no active cigarette smoking . to test for significant changes in control of individual risk factors and achieving optimal medical management , the generalized estimating equations were used to calculate predicted percentages and to test for significant differences from baseline . the analysis cohort consisted of 2210 patients at enrollment ; 1824 patients at 6 months ; and 1742 , 1320 , 822 , and 402 patients at 12 , 24 , 36 , and 48month followup , respectively . the glucose target of < 126 mg / dl was assessed for all patients regardless of diabetic status . patients were enrolled in crest from december 21 , 2000 , to july 18 , 2008 . the last patient to be followed up to 48 months after randomization was seen january 20 , 2010 . bp indicates blood pressure ; crest , carotid revascularization endarterectomy vs stenting trial ; ldl , lowdensity lipoprotein . values ( and se ) are the predicted values from a statistical model to account for missing data . p values test changes from baseline ( note that changes from baseline on smoking are provided in table 5 ) . table 1 also shows the status of vascular risk factors from randomization to 48 months of followup for symptomatic and asymptomatic patients overall . tables 2 and 3 show the status of these risk factors separately for symptomatic and asymptomatic patients . in the period from december 21 , 2000 , to january 3 , 2006 , when the first third of patients were enrolled in the trial , the rate of optimal riskfactor control at enrollment was 14% . table 4 shows the rates of optimal riskfactor control at enrollment by calendar year of enrollment . the proportion of patients achieving optimal control of the 4 riskfactor goals was 14.2% for the years 20002004 and rose to > 17% over the years 20052008 , although the improvements over time were not significant . vascular risk factors for patients who had symptomatic carotid stenosis at entry into crest * bp indicates blood pressure ; crest , carotid revascularization endarterectomy versus stenting trial ; ldl , lowdensity lipoprotein . values ( and se ) are the predicted values from statistical model to account for missing data . p values test changes from baseline ( note that changes from baseline on smoking are provided in table 5 ) . vascular risk factors for patients who had asymptomatic carotid stenosis at entry * bp indicates blood pressure ; ldl , lowdensity lipoprotein . values ( and se ) are the predicted values from statistical model to account for missing data . p values test changes from baseline ( note that changes from baseline on smoking are provided in table 5 ) . rates of optimal risk factor control at enrollment by calendar year of enrollment in crest crest indicates carotid revascularization endarterectomy vs stenting trial ; ldl , lowdensity lipoprotein . patients were considered to be optimally medically managed if they achieved at least 3 of the following therapeutic goals : ldl cholesterol < 100 mg / dl , glucose < 126 mg / dl , systolic blood pressure < 140 mm hg , and no active cigarette smoking . patients were considered to be optimally medically managed if they achieved all of the following therapeutic goals : ldl cholesterol < 100 mg / dl , glucose < 126 mg / dl , systolic blood pressure < 140 mm hg , and no active cigarette smoking . table 5 shows the change in proportion of all patients achieving targets for vascular risk factors from baseline to 6 months , from baseline to 12 months , from baseline to 24 months , from baseline to 36 months , and from baseline to 48 months . the same outcomes are shown separately for symptomatic and asymptomatic patients in tables 6 and 7 , respectively . by 6 months the majority of patients had achieved therapeutic targets for systolic blood pressure , blood glucose , and cigarette smoking ; however , less than two thirds of patients achieved ldl cholesterol levels < 100 mg / dl . the rates for achieving a target ldl of < 70 mg / dl were 22.9% at baseline , 27.4% at 12 months ( p=0.0003 versus baseline ) , and 27.9% at 48 months ( p=0.0258 versus baseline ) . only 16.7% of patients had optimal riskfactor control at enrollment in the trial , and although the change at 6 months was significant , this rate rose to only 27.1% . the percentage of patients achieving the ldl cholesterol goal improved from 59.1% at baseline to 73.6% at 48 months ( p<0.001 ) . the percentage achieving the systolic blood pressure goal improved from 51.6% to 65.1% ( p<0.001 ) , and the percentage achieving the glucose goal improved from 74.9% to 80.7% ( p=0.0101 ) . nonsmoking improved from 74.4% to 80.9% ( p<0.0001 ) . the percentage of optimal riskfactor control improved from 16.7% at baseline to 36.2% at 48 months ( p<0.001 ) . changes in goals attained from baseline to 6 , 12 , 24 , 36 , and 48 months for symptomatic and asymptomatic patients bp indicates blood pressure ; ldl , lowdensity lipoprotein . values ( and se ) are the predicted values from statistical model to account for missing data . changes in goals attained from baseline to 6 , 12 , 24 , 36 and 48 months for symptomatic patients bp indicates blood pressure ; ldl , lowdensity lipoprotein . values ( and se ) are the predicted values from statistical model to account for missing data . changes in goals attained from baseline to 6 , 12 , 24 , 36 and 48 months for asymptomatic patients bp indicates blood pressure ; ldl , lowdensity lipoprotein . values ( and se ) are the predicted values from statistical model to account for missing data . we observed that the majority of participants had control of blood pressure , glucose , and smoking but not ldl cholesterol at the time of enrollment . very early in the course of participation in the trial , the improvements seen at 6 months of followup were sustained for up to 4 years . the statistically significant improvement in risk factors , however , should not obscure the fact that the absolute levels of control of risk factors were far from ideal . only 28% had achieved optimal riskfactor control by 6 months , and only 35% had achieved it by 48 months . these rates are comparable to the rates of optimal riskfactor control achieved for patients without diabetes and coronary artery disease enrolled in the courage trial and are substantially better than what was achieved for patients with diabetes and coronary artery disease in the courage , bari 2d , and freedom trials . our results may not reflect the epidemiology of riskfactor control among patients with carotid stenosis . one would anticipate that riskfactor control is poorer among the general population with carotid stenosis because of the healthyparticipant bias . consequently , there may be an even greater opportunity to improve vascular risk factors in the general population of patients with carotid atherosclerosis . for patients with coronary artery disease , there is considerable opportunity to improve vascular risk factors . among the > 3000 patients with selfreported coronary artery disease in the regards study , only 16% met all 3 goals for aspirin , blood pressure , and ldl cholesterol . emphasis in the trial was placed on selecting sites with outstanding surgical and interventional teams and ensuring low risk for periprocedure stroke following either carotid endarterectomy or carotid stenting . the medical management was decentralized , even beyond the site level , because it was often provided by the usualcare physician ( generally the referring physician ) . accordingly , aggressive and timely control of risk factors by the site or by the crest central leadership was not feasible . the results of the medical monitoring were provided to the usualcare physician , but whether or not the results were acted on when provided ( eg , systolic blood pressures 140 mm hg or ldls 100 mg / dl ) or how they were acted on could not be determined . the enrollment period for crest was 7.5 years from 2000 until midyear 2008 . during this time , consequently , it is not surprising that control of risk factors at baseline improved in comparisons of the earlier years of enrollment to the later years . in the secondary prevention trial , vitamin intervention for stroke prevention ( visp ) , control of several risk factors at baseline also improved significantly during the 4.4year recruitment period from august 1997 to december 2001 . hypertension and hypercholesterolemia management and control improved ; there was an increase in use of antiplatelet medications , newer classes of antihypertensive medications , and lipidlowering drugs . similar to the crest recruitment period , during the visp enrollment period , national guidelines were released in addition to results from other secondary prevention trials . for stroke prevention trials with long recruitment periods , it is important that riskfactor management be standardized and be as stable as possible across all treatment groups so as not to differentially reduce the event rate and thus the ability of the trial to detect treatment effects . there is growing interest in conducting a randomized trial to compare intensive medical therapy and revascularization , similar to what has been done for stable coronary disease , atherosclerotic renal artery stenosis , and intracranial cerebrovascular disease . in the stenting versus aggressive medical management for intracranial stenosis ( sammpris ) study , a centralized model for treatment of risk factors was used . management of medications for risk factors was provided by the localsite neurologist but was specified in a stepbystep protocol . adherence to the protocol was monitored and enforced centrally by a sammpris medical core ; lifestyle coaching was also provided by a national provider under direction of the sammpris medical core . the control of risk factors was exceptional with these methods . at baseline , 4 months , and 1 year , the mean systolic blood pressure was 146.821.8 , 134.817.0 , and 133.817.1 mm hg , respectively . for ldl , the results at baseline , 4 months , and 1 year were 97.736.6 , 72.826.0 , and 68.227.5 mg / dl , respectively . consequently , along with the results we report in this paper , sammpris suggests that achieving intensive therapeutic targets with medical therapy may require a tightly integrated organizational model with close central management of a handson local medical management team . the soontobeinitiated crest2 trial of intensive medical management with or without revascularization in patients with asymptomatic carotid stenosis will use such an approach to management of vascular risk factors . the socalled inclusion benefit has not been clearly demonstrated in cancer trials ; however , it may be present in trials like crest2 , in which proven therapies will be given to all patients adjunctive to the interventions to which the patients are being randomized . we do not know how risk factors changed for patients who were eligible for crest but who refused participation . nonetheless , we suspect that patients benefited from being included in the trial because favorable effects were observed across key vascular risk factors . in crest , it is both surprising and disappointing that the rates of optimal riskfactor control , although relatively improved , remain poor in an absolute sense . one might have anticipated a greater effect on behaviors of the treating physicians ; however , reasons for lack of riskfactor control are multifaceted and involve not only the treating physicians but also other healthcare providers , the healthcare system , and the individual patient . a limitation of our study is that data are provided on only 4 metrics for vascular risk factors . data were not available for other important risk factors such as frequency of exercise or quality of diet . in addition , not every patient enrolled in the study had every followup visit , and not every risk factor was assessed at every followup visit . loss to followup was more problematic for the later visits than for the earlier visits . although missing visits did not occur at random , the proportion of missed visits was very low and was unlikely to have altered the basic conclusions that risk factors improved and that optimal riskfactor control was rarely achieved . cigarette smoking was assessed by selfreport and not by objective measures such as the detection of nicotine metabolites in serum ; however , smoking status tends to be slightly underestimated by selfreport . this implies that the rate of 17% for active smoking at 48 months after randomization conservatively estimates the true active smoking rate . in conclusion , significant improvements were seen in control of vascular risk factors in patients enrolled in crest . however , substantial opportunities remained for most patients to further improve upon medical management .
backgroundthe carotid revascularization endarterectomy versus stenting trial ( crest ) is a multicenter randomized trial of stenting versus endarterectomy in patients with symptomatic and asymptomatic carotid disease . 
 this study assesses management of vascular risk factors.methods and resultsmanagement was provided by the patient 's physician , with biannual monitoring results collected by the local site . 
 therapeutic targets were lowdensity lipoprotein , cholesterol < 100 mg / dl , systolic blood pressure < 140 mm hg , fasting blood glucose < 126 mg / dl , and nonsmoking status . 
 optimal control was defined as achieving all 4 goals concurrently . 
 generalized estimating equations were used to compare risk factors at baseline with those observed in scheduled followup visits for up to 48 months . in the analysis cohort of 2210 , significant improvements in riskfactor control were observed across risk factors for all followup visits compared with baseline . at 48 months , 
 achievement of the lowdensity lipoprotein cholesterol goal improved from 59.1% to 73.6% ( p<0.001 ) , achievement of the systolic blood pressure goal improved from 51.6% to 65.1% ( p<0.001 ) , achievement of the glucose goal improved from 74.9% to 80.7% ( p=0.0101 ) , and nonsmoking improved from 74.4% to 80.9% ( p<0.0001 ) . 
 the percentage with optimal riskfactor control also improved significantly , from 16.7% to 36.2% ( p<0.001 ) , but nearly 2 of 3 study participants did not achieve optimal control during the study.conclusionssitebased riskfactor control improved significantly in the first 6 months and over the long term in crest but was often suboptimal . 
 intensive medical management should be considered for future trials of carotid revascularization.clinical trial registrationurl : clinicaltrials.gov . 
 unique identifier : nct00004732 .