soft tissue augmentation by means of illicit injections of unknown substances has led to disastrous long - term effects and complications . regrettably , this practice is still carried on by non - medical practitioners using adulterated injection materials for treating uninformed patients who choose cheaper and easier options . in fact , the patients who came to plastic surgeons with complications are just a small number of patients among the multitude of victims who actually had the injections . until now , there is no guideline regarding the diagnosis and management of breasts injected with silicone , although several studies have proposed algorithms for the management of  symptomatic  injected breasts . for asymptomatic injected breasts , herein , we present two cases of asymptomatic patients with a history of liquid silicone injections who refused to have a mastectomy and chose instead to undergo reduction mammoplasty to enhance the appearance of their breasts . the controversy regarding the assessment and management of asymptomatic silicone - injected breasts is our main debate . a 45-year - old woman with a history of bilateral breast augmentation with liquid silicone injections 10 years earlier visited our clinic . she denied any redness , pain , skin changes or nipple discharge in either breast . , there was breast ptosis grade two and multiple hard , solid masses could be palpated throughout both breasts [ figure 1 ] . there was no pain , skin alterations , nipple areola complex ( nac ) or axillary lymph node involvement . mammogram and magnetic resonance imaging ( mri ) results were consistent with bilateral breast silicone granuloma [ figures 2 and 3 ] . it shows ptotic large breasts without any visible deformity apart from a notch in the left areola ( black arrow ) due to uneven distribution of the silicone masses . it revealed the presence of diffuse multiple nodules in both breast parenchymas , in various sizes ; however , the presence of stellate lesion and micro - calcification was unclear . mediolateral oblique view of the right breast ( a ) and the left breast ( b ) magnetic resonance imaging image . it showed diffuse multiple nodules in both breasts with intermediate signal intensity on the t1-weighted image ( a ) and high signal intensity on the t2-weighted image ( b ) . skin , nipple areola complex and axillary lymph nodes of both breasts were within normal limits the patient was given two options : 
 bilateral subcutaneous mastectomy and immediate reconstruction with autologous tissue , orbreast reduction . 
  bilateral subcutaneous mastectomy and immediate reconstruction with autologous tissue , or she decided to undergo breast reduction surgery . the technique of reduction mammoplasty used was supero - medial pedicle with a vertical scar . the volume of breast tissue removed from the right and left breasts was 250 g and 216 g , respectively . the histopathology examination showed breast tissue infiltrated with small and large vacuoles and chronic inflammatory cells . signs of malignancy were not found in the specimen . at 22-months follow - up , the patient had no complaint with her current breast shape and her nipple sensation was intact [ figure 4 ] . twenty - two - month postoperative view . one year after surgery , the patient gave birth and gained 10 kg since the surgery . she was satisfied with the result ; hypertrophic scar formation was treated with silicone gel . ( a ) anterior view ( b ) lateral view the second patient was a 36-year - old woman , g3p3a0 , who came with similar complaints , medical history , physical examination and mammography results . the sonographic image showed diffuse multiple cystic lesions covering the fibroglandular breast tissue and infiltrating the subcutaneous layer . she experienced uneventful healing and was satisfied with the result up to 6-months follow - up . 1 , follow - up mammogram and mri could not be taken because she refused to have them . a 45-year - old woman with a history of bilateral breast augmentation with liquid silicone injections 10 years earlier visited our clinic . she denied any redness , pain , skin changes or nipple discharge in either breast . , there was breast ptosis grade two and multiple hard , solid masses could be palpated throughout both breasts [ figure 1 ] . there was no pain , skin alterations , nipple areola complex ( nac ) or axillary lymph node involvement . mammogram and magnetic resonance imaging ( mri ) results were consistent with bilateral breast silicone granuloma [ figures 2 and 3 ] . it shows ptotic large breasts without any visible deformity apart from a notch in the left areola ( black arrow ) due to uneven distribution of the silicone masses . it revealed the presence of diffuse multiple nodules in both breast parenchymas , in various sizes ; however , the presence of stellate lesion and micro - calcification was unclear . mediolateral oblique view of the right breast ( a ) and the left breast ( b ) magnetic resonance imaging image . it showed diffuse multiple nodules in both breasts with intermediate signal intensity on the t1-weighted image ( a ) and high signal intensity on the t2-weighted image ( b ) . skin , nipple areola complex and axillary lymph nodes of both breasts were within normal limits the patient was given two options : 
 bilateral subcutaneous mastectomy and immediate reconstruction with autologous tissue , orbreast reduction . 
  bilateral subcutaneous mastectomy and immediate reconstruction with autologous tissue , or she decided to undergo breast reduction surgery . the technique of reduction mammoplasty used was supero - medial pedicle with a vertical scar . the volume of breast tissue removed from the right and left breasts was 250 g and 216 g , respectively . the histopathology examination showed breast tissue infiltrated with small and large vacuoles and chronic inflammatory cells . signs of malignancy were not found in the specimen . at 22-months follow - up , the patient had no complaint with her current breast shape and her nipple sensation was intact [ figure 4 ] . twenty - two - month postoperative view . one year after surgery , the patient gave birth and gained 10 kg since the surgery . she was satisfied with the result ; hypertrophic scar formation was treated with silicone gel . the second patient was a 36-year - old woman , g3p3a0 , who came with similar complaints , medical history , physical examination and mammography results . the sonographic image showed diffuse multiple cystic lesions covering the fibroglandular breast tissue and infiltrating the subcutaneous layer . she experienced uneventful healing and was satisfied with the result up to 6-months follow - up . 1 , follow - up mammogram and mri could not be taken because she refused to have them . silicone products were first developed by the dow corning corporation for military purposes . in 1960 , the company created medical - grade silicone , which is pure in quality , sterile and of constant viscosity . it was initially used for waterproofing skin , primarily in burn victims . however , this material was misused by certain physicians and by lay clinics as a cosmetic injection material , especially for breast augmentation . injection of silicone into the breast tissue for augmentation has been notoriously related to various complications . most common are the formation of silicone granuloma and silicone mastitis . nevertheless , the development of symptoms is different for each individual . some patients may live with injectable silicone inside their body without any serious symptoms ( asymptomatic ) . the main concern of surgeons and patients is the possibility of developing cancer in breasts with silicone injection . several studies have tried to relate liquid silicone injection and the occurrence of malignancy yet their causal relationship has not been proven . risk factors for breast cancer such as age , family history of breast cancer , cancer - predisposing brca mutations , nulliparity and the use of hormonal therapy may play a more important role than silicone injection alone in regards to the incidence of breast cancer . it is widely accepted that the use of injected materials can obscure early detection of breast cancer by means of clinical breast examination ( cbe ) and routine breast imaging ( mammography and ultrasonography ) ; thus diagnosing breast cancer in silicone - injected patients may be difficult . mri has been recommended as an additional screening tool because it has the ability to detect the breast lesions and differentiate benign and malignant tumours in the breasts from injectable materials including silicone . a cost - effectiveness analysis study suggested the strategy of alternating between mri and regular screening ( i.e. , a combination of mammography and cbe ) every other year for women at 20 - 25% lifetime risk of breast cancer . however , due to the differences in study population , this recommendation can not be adopted directly for women with a history of silicone injection and further study is needed for this specific population . to manage asymptomatic silicone - injected breasts , chiu et al . recommended follow - up while chuangsuwanich et al . skin / nipple sparing mastectomy procedure can not totally remove the injectable materials because they may have infiltrated the skin and nac . moreover , it is difficult to recommend mastectomy in breast - oriented ( beauty conscious ) patients . it was the patients decision to choose breast reduction even after they were explained in detail the risks and treatment options . therefore , we decided to perform breast reduction in our patient after malignancy had been excluded by mri . even though it is not commonly implemented in silicone - injected breasts , it has been performed by crdenas - camarena on his patients who had a history of silicone injection but did not agree to have a total mastectomy . in the author 's opinion , skin - only mastopexy is not suggested in this case because the breasts will be difficult to elevate and mould due to the presence of granulomata . obviously , this surgery does not modify the detection of breast cancer or prevent the occurrence of complications in the future because the silicone materials can not be completely removed from the breasts . however , this procedure increased our patients satisfaction with their breast appearance and consequently improved their quality of life ( qol ) . studies have proven that breast reduction surgery significantly improves both satisfaction with breast appearance and qol of the patients . reduction mammoplasty may be the alternative option for women with a history of liquid silicone injection who have no symptoms but desire to preserve their breasts and improve the aesthetic appearance of the breasts . after the procedure , screening mri may be performed every 2 years to detect the presence of benign and malignant lesions in the future .
even though silicone injection for breast augmentation has been related to disastrous long - term effects and complications , some patients do not develop significant symptoms at all ( asymptomatic ) . 
 unfortunately , the management of asymptomatic silicone - injected breast is still unclear and has never been reported exclusively . 
 we present two cases of asymptomatic patients with a history of liquid silicone injections who refused to have a mastectomy . 
 they were concerned with the breast ptosis and chose to undergo reduction mammoplasty to improve the appearance of the breasts . 
 magnetic resonance imaging may be useful as an additional screening tool to confirm the diagnosis and exclude the presence of malignancy in breasts with injected silicone . 
 we believe that breast reduction may be the alternative option for women with a history of liquid silicone injection who have no symptoms but desire to preserve their breasts and improve their aesthetics .