nonocclusive mesenteric ischemia ( nomi ) was reported in a heart failure patient by ende in 1958 . in dialysis patients , dahlberg et al . reported 6 patients with acute mesenteric ischemia , and 3 of them were nomi . nomi is the cause in at least 20% to 30% of cases of acute mesenteric ischemia , and the mortality rates of nomi were reported from 71% to 100% . reported that nomi was the cause of mortality in 9% ( 5/56 ) of the deaths in the dialysis population . we describe nomi in a patient with hypotensive episodes in dialysis therapy who was admitted with abdominal pain and who undertook colectomy . a 66-year - old woman on maintenance hemodialysis for 5 years was admitted with syncope , abdominal pain and chilly sensation . hemodialysis was being done 3 times per week : her dry body weight was 46 kg and the interdialytic weight changes were about 3 kg . her interdialytic , systolic and diastolic pressures had been 100 to 140 mmhg and 90 to 100 mmhg on the supine position , respectively . during hemodialysis , systolic pressures had been above 100 mmhg on supine position . however , interdialytic and intradialytic blood pressures had showed a tendency to decrease for several months prior to admission . so , she had not taken antihypertensive medication to prevent intradialytic hypotension . since 7 days prior to admission , blood pressure on the supine position during hemodialysis had frequently fallen to 80/50 mmhg . on admission , the blood pressure on the supine position was 80/50 mmhg , body temperature 38.8c , heart rate 104 per minute and respiratory rate 26 per minute . laboratory data were as follows : leukocyte count 5200/mm with normal differential count , hemoglobin 12.8 g / dl , platelet count 112000/l , bun 60 mg / dl , serum creatinine 7.3 mg / dl , calcium 9.8 mg / dl , phosphorus 7.3 mg / dl , ast 63 iu / l , alt 64 iu / l , alkaline phosphatase 89 iu / l , -glutamyl transferase 55 iu / l , bilirubin 0.54 mg / dl , total protein 8.6 g / dl , albumin 5.7 g / dl , amylase 480 iu / l ( normal , 60180 ) , lipase 13 iu / l ( normal , 30190 ) , pt 11.6 second ( inr 0.98 sec ) and aptt 40.1 second ( control 30 sec ) . four days later , she complained of progressive abdominal pain , and rebound tenderness and leukocytosis ( leukocyte count 13900/mm ) with left shift were noted . abdominal ct scan showed a distended gall bladder with sludge . under the impression of acalculous cholesystitis ischemic necrosis at the sigmoid colon and mesocolon in addition to acalculous cholesystitis were found , and hartman 's operation and cholecystectomy were undertaken . after that , systolic blood pressures rose to 80 to 100 mmhg , but intradialytic hypotension ( 60/30 mmhg ) occurred recurrently . we started midodrine 2.5 mg just before hemodialysis and increased the dose up to 7.5 mg . although hypotensive episodes occurred , the degree of hypotension was mild and the symptoms associated with hypotension did not occur ( figure 2 ) . in chronic renal failure , peptic ulcer and colonic dysfunction are the most common gastrointestinal manifestations . however , ischemic bowel disease is less frequently recognized in the dialysis population . as a cause of acute mesenteric ischemia reported that 11 of 12 patients with acute abdomen undergoing hemodialysis were diagnosed as nomi . therefore , they insisted that nomi be the most common cause of acute abdomen in dialyzed patients and should be the most probable diagnosis until proven otherwise . patients with esrd have several risk factors for bowel infarction , which include advanced atherosclerosis , low cardiac output states , several medications and intradialytic hypotensive episodes . low cardiac output states such as heart failure , myocardial infarction , arrhythmia , sepsis and hypovolemia , may decrease splanchnic blood flow and cause vasoconstriction by excessive sympathetic activity that will eventually lead to nomi . reduced blood flow from vasoconstriction induces inadequate intestinal tissue oxygenation and results in vulnerability to tissue injury as well as reperfusion injury by oxygen radicals . symptomatic intradialytic hypotension has been described to occur in as many as 20% to 50% of patients . this problem has been ascribed to multiple factors including excessively rapid ultrafiltration rate , autonomic dysfunction , disturbance in cardiac function and vascular responsiveness and paradoxical withdrawal of sympathetic activity . in our case the cause of hypotensive episodes was not clear , but uremia - induced autonomic dysfunction might be considered . head - up tilting test may be helpful in making a diagnosis of autonomic dysfuction . because symptoms and signs of nomi are nonspecific although fever , ileus , diarrhea and leukocytosis were found , they were not constant manifestations . in contrast to charra 's report , howard et al . reported the absence of abdominal pain in 20 to 25% of cases with nomi . splanchnic vasospasm , which may develop in hours or days after the initial insult , results in a delayed appearance of the disorder . therefore , the diagnosis of this condition should be considered whenever dialysis patients with risk factors complain of severe and abrupt abdominal discomfort within several hours or several days after intradialytic hypotensive episodes . four days after nonspecific abdominal pain , our case was diagnosed as nomi by surgical and pathological findings . after colectomy , this patient continued to show recurrent intradialytic hypotensive episodes . for the prevention of these episodes , a variety of maneuvers , including sodium modeling and cooling of the dialysate , midodrine is an oral agent with selective -adrenergic agonist activity that has been used successfully in the treatment of orthostatic hypotension secondary to autonomic dysfunction . the efficacy of midodrine therapy in patients with intradialytic hypotension was reported by blowey et al .. midodrine is a prodrug that is rapidly and almost completely absorbed from the gastrointestinal tract after oral administration . the peak plasma levels of midodrine and its active metabolites , de - glymidodrine , were observed 60 and 90 minutes after the oral dose , respectively . de - glymidodrine was effectively removed by hemodialysis ( t1/2 : 10 hrs without dialysis , 1.4 hr with dialysis ) . the effect of midodrine to increase blood pressure comes from its constrictive effect on the arterioles and venous capacitant vessels . in this way , it prevents venous blood pooling and augments venous return which will subsequently increase cardiac output . it has minimal cardiac and central nervous system effects by virtue of its -1 receptor specificity and its inability to cross the blood - brain barrier , respectively . adverse effects such as piloerctor reactions , scalp pruritus , urinary urgency and headache were observed but they were usually mild . in our case , midodrine has decreased intradialytic hypotensive episodes without adverse effects for six months . the blood pressure became more stable after a trial of midodrine than before ( figure 2 ) . we compared the frequency of intradialytic hypotensive episode between before and after a trial of midodrine when ultrafiltration volume was below 3 kg . the frequencies of ultrafiltration volume under 3 kg were 7 and 11 of each 14 sessions before and after midodrine therapy . intradialytic hypotensive episodes occurred in 6 of 7 sessions before midodrine therapy and 4 of 11 sessions after midodrine therapy , respectively ( p = 0.04 ) . intradialytic hypotension , before midodrine therapy , had fallen to 50 mmhg of systolic pressures , but the systolic pressures had fallen only to 80 mmhg after midodrine therapy . in conclusion , nomi should be included in differential diagnosis when patients on maintenance dialysis present abdominal pain after intradialytic hypotension . also , we suggest that midodrine be considered for the treatment of intradialytic hypotension of unknown origin or unresponsiveness to other trials .
nonocclusive mesenteric ischemia ( nomi ) is known to occupy about 25% to 60% of intestinal infarction . 
 nomi has been reported to be responsible for 9% of the deaths in the dialysis population and the postulated causes of nomi include intradialytic hypotension , atherosclerosis and medications , such as diuretics , digitalis and vasopressors . 
 clinical manifestations , such as fever , diarrhea and leukocytosis , are nonspecific , which makes early diagnosis of nomi very difficult . 
 case : a 66-year - old woman on maintenance hemodialysis for 5 years was admitted with syncope , abdominal pain and chilly sensation . since 7 days prior to admission , blood pressure on the supine position during hemodialysis 
 had frequently fallen to 80/50 mmhg . 
 four days later , she complained of progressive abdominal pain . rebound tenderness and leukocytosis ( wbc 13900/mm3 ) with left shift were noted . 
 stool examination was positive for occult blood . 
 abdominal ct scan showed a distended gall bladder with sludge . under the impression of acalculous cholecystitis 
 , she was operated on . 
 surgical and pathologic findings of colon colon were compatible with nomi . 
 because of recurrent intradialytic hypotension , we started midodrine 2.5 mg just before hemodialysis and increased the dose up to 7.5 mg . 
 after midodrine therapy , blood pressure during dialysis became stable and the symptoms associated with hypotension did not recur . 
 conclusion : as nomi may occur within several hours or days after an intradialytic hypotensive episode , abdominal pain should be carefully observed and nomi should be considered as a differential diagnosis . in addition , we suggest that midodrine be considered to prevent intradialytic hypotensive episodes .