the china national diabetes and metabolic disorders study was a cross - sectional study conducted from june 2007 to may 2008 . the study population and the methods used to recruit participants have previously been reported ( 2 ) . in brief , a multistage , stratified sampling method was used to recruit a population - representative sample of individuals aged 20 years who lived in their current residence for at least 5 years . the study was conducted in a total of 152 urban street districts and 112 rural villages selected from 12 provinces and autonomous regions in addition to the municipalities of beijing and shanghai . a total of 54,240 individuals were invited to participate in the study , and 47,325 attended , which give a response rate of 87.3% . a total of 41,809 participants aged 2074 years were included in the current data analyses after exclusion of 2,151 individuals with previously diagnosed diabetes , 343 aged 75 years , and 2,785 with missing data on demographic information , fasting or 2-h blood glucose levels , waist circumference , bmi , systolic blood pressure or diastolic blood pressure , family history of diabetes , or information on education . to minimize the influence of extreme values , we further excluded 69 individuals with waist circumference > 99.9 percentile ( 120 cm ) or < 0.1 percentile ( 56 cm ) , 71 individuals with bmi > 99.9 percentile ( 39.74 kg / m ) or < 0.1 percentile ( 15.23 kg / m ) , 53 individuals with systolic blood pressure > 99.9 percentile ( 205 mmhg ) or < 0.1 percentile ( 80 mmhg ) , and 44 individuals with diastolic blood pressure > 99.9 percentile ( 125 mmhg ) or < 0.1 percentile ( 50 mmhg ) . the survey was approved by the institutional review board or local ethics committee , and informed consent was obtained from all participants . a population - based cross - sectional diabetes survey was conducted in three urban and three rural administrative areas in qingdao , china in 2006 ( 21 ) . a stratified , random cluster sampling method was used to recruit a representative sample of the general population who had lived in qingdao city for at least 5 years . a total of 5,355 individuals aged 3574 years attended the 2006 cross - sectional diabetes survey . in 2009 , 4,482 of the 5,355 participants who did not have diabetes at baseline were invited to join a follow - up to determine the incident cases of type 2 diabetes , and 1,294 attended . data from 1,162 of the 1,294 participants who had all variables required for the validation study were used to validate the risk scores . a population - based cross - sectional diabetes survey was conducted in qingdao , china , in 2009 . the survey used the same sampling method and was conducted in the same areas as the 2006 survey above . a total of 7,612 individuals aged 3574 years were invited to participate in the survey , and 5,110 attended , which gave a response rate of 67.1% . both surveys were approved by the qingdao municipal health bureau and the local ethics committee in the qingdao municipal centers for disease control and prevention , and informed consent was obtained from all participants . in the exploratory , validation 1 , and validation 2 population , participants were interviewed by trained doctors or nurses in the local community clinics . residence area was divided into rural area and urban area including urban and suburban area . educational level was divided into college or higher level and others including secondary school and elementary school or illiterate . smoking status was classified as current smoker if smoking at least one cigarette daily and other including nonsmokers and ex - smokers . physical activity was defined as participation in moderate or vigorous activity for at least 90 min or more per week . hypertension was defined as self - report of hypertension diagnosed by a doctor or on antihypertensive treatment or defined by systolic blood pressure 140 mmhg or diastolic blood pressure 90 mmhg based on the mean of the two measures for each individual in the exploratory population and three measures in validation 1 and validation 2 . diabetes in a first - degree relative ( parents , siblings , and offspring ) was considered a family history of diabetes . height and weight were measured using a height - weight scale that had been calibrated before using and with subjects standing with bare feet and light clothing . waist circumference was measured at the middle point level between lower rib margin and iliac crest . waist circumference was divided into six categories in men and women : < 75 , 75 and < 80 , 80 and < 85 , 85 and < 90 , 90 and < 95,and 95 cm in men and < 70 , 70 and < 75 , 75 and < 80 , 80 and < 85 , 85 and < 90 , and 90 cm in women . bmi was calculated as weight in kilograms divided by the square of height in meters and divided into four categories : < 22 , 22 and < 24 , 24 and < 30 , and 30 kg / m . systolic blood pressure was divided into seven categories : < 110 , 110 and < 120 , 120 and < 130 , 130 and < 140 , 140 and < 150 , 150 and < 160 , and 160 mmhg . the study participants were instructed to maintain their usual physical activity and have at least 3 days of unrestricted diet ( 150 g carbohydrate / day ) and an overnight fast of at least 10 h before examination . blood samples were collected before glucose ingestion and 2 h after a 75-g anhydrous glucose load . plasma glucose ( pg ) was measured by the hexokinase enzymatic method in the exploratory population and the glucose oxidase method in the validation 1 and validation 2 population . known diabetes was defined as self - report of diabetes diagnosed by a doctor or on information on treatment , and individuals with known diabetes were excluded from the analysis . according to the world health organization definition ( 22 ) , previously undiagnosed type 2 diabetes was defined as having either fasting plasma glucose ( fpg ) 7.0 mmol / l or 2-h pg 11.1 the exploratory population was comprised of more women than men because more women participated in the china national diabetes and metabolic disorders study . in addition , the exploratory population was younger than the two validation populations . to check the possible impact of the imbalance in sex and age , we performed two sensitivity analyses . second , a risk score was derived for the exploratory population by limiting the age to 3574 years . the results of the two sensitivity analyses were compared , with the main results reported in the current article . statistical analysis was performed using spss for windows , version 15.0 ( spss , chicago , il ) and stata , version 11.2 ( statacorp , college station , tx ) . continuous variables are presented as means  sd and categorical data as number and percentage . a multivariable logistic regression model using the forward stepwise likelihood ratio method was fitted with candidate risk factors including age , sex , bmi , waist circumference , systolic blood pressure , family history of diabetes , educational level , and residence . the new chinese diabetes risk score was derived by multiplying the -coefficients of the significant variable by 10 and rounding to the nearest integer . the hosmer - lemeshow test was used to investigate how close the prevalence predicted by the multivariate model was to the observed prevalence . we classified the predicted probabilities of having diabetes according to its quartiles ( 2.4% , > 2.4% and 4.9% , > 4.9% and 9.4% , and > 9.4% ) based on a multivariable model fitted with age , sex , waist circumference , and family history of diabetes that were the components of the qingdao chinese diabetes risk score ( 7 ) . net reclassification improvement ( 23 ) was calculated to test whether adding bmi and systolic blood pressure could improve the classification of the predicted probabilities of the multivariable model . validation of the new chinese diabetes risk score developed from the exploratory population was conducted in the validation 1 and validation 2 population . the receiver operating characteristic ( roc ) curve was obtained by plotting sensitivity against 1  specificity at each cutoff value . the optimal cutoff point was identified using the youden index , which was at the maximum sum of the sensitivity and specificity  1 . diagnostic accuracy was assessed by the area under the curve ( auc ) ( 24 ) . the china national diabetes and metabolic disorders study was a cross - sectional study conducted from june 2007 to may 2008 . the study population and the methods used to recruit participants have previously been reported ( 2 ) . in brief , a multistage , stratified sampling method was used to recruit a population - representative sample of individuals aged 20 years who lived in their current residence for at least 5 years . the study was conducted in a total of 152 urban street districts and 112 rural villages selected from 12 provinces and autonomous regions in addition to the municipalities of beijing and shanghai . a total of 54,240 individuals were invited to participate in the study , and 47,325 attended , which give a response rate of 87.3% . a total of 41,809 participants aged 2074 years were included in the current data analyses after exclusion of 2,151 individuals with previously diagnosed diabetes , 343 aged 75 years , and 2,785 with missing data on demographic information , fasting or 2-h blood glucose levels , waist circumference , bmi , systolic blood pressure or diastolic blood pressure , family history of diabetes , or information on education . to minimize the influence of extreme values , we further excluded 69 individuals with waist circumference > 99.9 percentile ( 120 cm ) or < 0.1 percentile ( 56 cm ) , 71 individuals with bmi > 99.9 percentile ( 39.74 kg / m ) or < 0.1 percentile ( 15.23 kg / m ) , 53 individuals with systolic blood pressure > 99.9 percentile ( 205 mmhg ) or < 0.1 percentile ( 80 mmhg ) , and 44 individuals with diastolic blood pressure > 99.9 percentile ( 125 mmhg ) or < 0.1 percentile ( 50 mmhg ) . the survey was approved by the institutional review board or local ethics committee , and informed consent was obtained from all participants . a population - based cross - sectional diabetes survey was conducted in three urban and three rural administrative areas in qingdao , china in 2006 ( 21 ) . a stratified , random cluster sampling method was used to recruit a representative sample of the general population who had lived in qingdao city for at least 5 years . a total of 5,355 individuals aged 3574 years attended the 2006 cross - sectional diabetes survey . in 2009 , 4,482 of the 5,355 participants who did not have diabetes at baseline were invited to join a follow - up to determine the incident cases of type 2 diabetes , and 1,294 attended . data from 1,162 of the 1,294 participants who had all variables required for the validation study were used to validate the risk scores . a population - based cross - sectional diabetes survey was conducted in qingdao , china , in 2009 . the survey used the same sampling method and was conducted in the same areas as the 2006 survey above . a total of 7,612 individuals aged 3574 years were invited to participate in the survey , and 5,110 attended , which gave a response rate of 67.1% . both surveys were approved by the qingdao municipal health bureau and the local ethics committee in the qingdao municipal centers for disease control and prevention , and informed consent was obtained from all participants . in the exploratory , validation 1 , and validation 2 population , participants were interviewed by trained doctors or nurses in the local community clinics . residence area was divided into rural area and urban area including urban and suburban area . educational level was divided into college or higher level and others including secondary school and elementary school or illiterate . smoking status was classified as current smoker if smoking at least one cigarette daily and other including nonsmokers and ex - smokers . physical activity was defined as participation in moderate or vigorous activity for at least 90 min or more per week . hypertension was defined as self - report of hypertension diagnosed by a doctor or on antihypertensive treatment or defined by systolic blood pressure 140 mmhg or diastolic blood pressure 90 mmhg based on the mean of the two measures for each individual in the exploratory population and three measures in validation 1 and validation 2 . diabetes in a first - degree relative ( parents , siblings , and offspring ) was considered a family history of diabetes . height and weight were measured using a height - weight scale that had been calibrated before using and with subjects standing with bare feet and light clothing . waist circumference was measured at the middle point level between lower rib margin and iliac crest . waist circumference was divided into six categories in men and women : < 75 , 75 and < 80 , 80 and < 85 , 85 and < 90 , 90 and < 95,and 95 cm in men and < 70 , 70 and < 75 , 75 and < 80 , 80 and < 85 , 85 and < 90 , and 90 cm in women . bmi was calculated as weight in kilograms divided by the square of height in meters and divided into four categories : < 22 , 22 and < 24 , 24 and < 30 , and 30 kg / m . systolic blood pressure was divided into seven categories : < 110 , 110 and < 120 , 120 and < 130 , 130 and < 140 , 140 and < 150 , 150 and < 160 , and 160 mmhg . the study participants were instructed to maintain their usual physical activity and have at least 3 days of unrestricted diet ( 150 g carbohydrate / day ) and an overnight fast of at least 10 h before examination . blood samples were collected before glucose ingestion and 2 h after a 75-g anhydrous glucose load . plasma glucose ( pg ) was measured by the hexokinase enzymatic method in the exploratory population and the glucose oxidase method in the validation 1 and validation 2 population . known diabetes was defined as self - report of diabetes diagnosed by a doctor or on information on treatment , and individuals with known diabetes were excluded from the analysis . according to the world health organization definition ( 22 ) , previously undiagnosed type 2 diabetes was defined as having either fasting plasma glucose ( fpg ) 7.0 mmol / l or 2-h pg 11.1 the exploratory population was comprised of more women than men because more women participated in the china national diabetes and metabolic disorders study . to check the possible impact of the imbalance in sex and age , we performed two sensitivity analyses . second , a risk score was derived for the exploratory population by limiting the age to 3574 years . the results of the two sensitivity analyses were compared , with the main results reported in the current article . a population - based cross - sectional diabetes survey was conducted in three urban and three rural administrative areas in qingdao , china in 2006 ( 21 ) . a stratified , random cluster sampling method was used to recruit a representative sample of the general population who had lived in qingdao city for at least 5 years . a total of 5,355 individuals aged 3574 years attended the 2006 cross - sectional diabetes survey . in 2009 , 4,482 of the 5,355 participants who did not have diabetes at baseline were invited to join a follow - up to determine the incident cases of type 2 diabetes , and 1,294 attended . data from 1,162 of the 1,294 participants who had all variables required for the validation study were used to validate the risk scores . a population - based cross - sectional diabetes survey was conducted in qingdao , china , in 2009 . the survey used the same sampling method and was conducted in the same areas as the 2006 survey above . a total of 7,612 individuals aged 3574 years were invited to participate in the survey , and 5,110 attended , which gave a response rate of 67.1% . both surveys were approved by the qingdao municipal health bureau and the local ethics committee in the qingdao municipal centers for disease control and prevention , and informed consent was obtained from all participants . in the exploratory , validation 1 , and validation 2 population , residence area was divided into rural area and urban area including urban and suburban area . educational level was divided into college or higher level and others including secondary school and elementary school or illiterate . smoking status was classified as current smoker if smoking at least one cigarette daily and other including nonsmokers and ex - smokers . physical activity was defined as participation in moderate or vigorous activity for at least 90 min or more per week . hypertension was defined as self - report of hypertension diagnosed by a doctor or on antihypertensive treatment or defined by systolic blood pressure 140 mmhg or diastolic blood pressure 90 mmhg based on the mean of the two measures for each individual in the exploratory population and three measures in validation 1 and validation 2 . diabetes in a first - degree relative ( parents , siblings , and offspring ) was considered a family history of diabetes . height and weight were measured using a height - weight scale that had been calibrated before using and with subjects standing with bare feet and light clothing . waist circumference was measured at the middle point level between lower rib margin and iliac crest . waist circumference was divided into six categories in men and women : < 75 , 75 and < 80 , 80 and < 85 , 85 and < 90 , 90 and < 95,and 95 cm in men and < 70 , 70 and < 75 , 75 and < 80 , 80 and < 85 , 85 and < 90 , and 90 cm in women . bmi was calculated as weight in kilograms divided by the square of height in meters and divided into four categories : < 22 , 22 and < 24 , 24 and < 30 , and 30 kg / m . systolic blood pressure was divided into seven categories : < 110 , 110 and < 120 , 120 and < 130 , 130 and < 140 , 140 and < 150 , 150 and < 160 , and 160 mmhg . the study participants were instructed to maintain their usual physical activity and have at least 3 days of unrestricted diet ( 150 g carbohydrate / day ) and an overnight fast of at least 10 h before examination . blood samples were collected before glucose ingestion and 2 h after a 75-g anhydrous glucose load . plasma glucose ( pg ) was measured by the hexokinase enzymatic method in the exploratory population and the glucose oxidase method in the validation 1 and validation 2 population . known diabetes was defined as self - report of diabetes diagnosed by a doctor or on information on treatment , and individuals with known diabetes were excluded from the analysis . according to the world health organization definition ( 22 ) , previously undiagnosed type 2 diabetes was defined as having either fasting plasma glucose ( fpg ) 7.0 mmol / l or 2-h pg 11.1 the exploratory population was comprised of more women than men because more women participated in the china national diabetes and metabolic disorders study . to check the possible impact of the imbalance in sex and age , we performed two sensitivity analyses . second , a risk score was derived for the exploratory population by limiting the age to 3574 years . the results of the two sensitivity analyses were compared , with the main results reported in the current article . statistical analysis was performed using spss for windows , version 15.0 ( spss , chicago , il ) and stata , version 11.2 ( statacorp , college station , tx ) . continuous variables are presented as means  sd and categorical data as number and percentage . a multivariable logistic regression model using the forward stepwise likelihood ratio method was fitted with candidate risk factors including age , sex , bmi , waist circumference , systolic blood pressure , family history of diabetes , educational level , and residence . the new chinese diabetes risk score was derived by multiplying the -coefficients of the significant variable by 10 and rounding to the nearest integer . the hosmer - lemeshow test was used to investigate how close the prevalence predicted by the multivariate model was to the observed prevalence . we classified the predicted probabilities of having diabetes according to its quartiles ( 2.4% , > 2.4% and 4.9% , > 4.9% and 9.4% , and > 9.4% ) based on a multivariable model fitted with age , sex , waist circumference , and family history of diabetes that were the components of the qingdao chinese diabetes risk score ( 7 ) . net reclassification improvement ( 23 ) was calculated to test whether adding bmi and systolic blood pressure could improve the classification of the predicted probabilities of the multivariable model . validation of the new chinese diabetes risk score developed from the exploratory population was conducted in the validation 1 and validation 2 population . the receiver operating characteristic ( roc ) curve was obtained by plotting sensitivity against 1  specificity at each cutoff value . the optimal cutoff point was identified using the youden index , which was at the maximum sum of the sensitivity and specificity  1 . diagnostic accuracy was assessed by the area under the curve ( auc ) ( 24 ) . the exploratory population was younger and less hypertensive and had a lower proportion of undiagnosed type 2 diabetes and a higher proportion of urban living compared with validation 1 and validation 2 . the exploratory population and validation 2 population were less obese and had a lower proportion of family history of diabetes compared with the validation 1 population ( table 1 ) . a total of 3,365 ( 7.4% ) individuals who participated in the china national diabetes and metabolic disorders study and had no prior history of diagnosis of diabetes were excluded from the current data analyses because of age 75 years , missing variables , or extreme values . they were older ( age 49.4 years [ 95 ci 48.949.9 ] vs. 44.1 years [ 44.044.2 ] ) , had a higher proportion of men ( 44.9 vs. 39.5% , p < 0.001 ) , higher bmi ( 24.6 kg / m [ 95% ci 24.424.7 ] vs. 24.0 kg / m [ 24.024.1 ] ) , and higher systolic blood pressure ( 124.6 mmhg [ 95% ci 123.9125.2 ] vs. 121.8 mmhg [ 121.6122.0 ] ) but lower fpg ( 5.19 mmol / l [ 95% ci 5.155.23 ] vs. 5.24 mmol / l [ 5.235.25 ] as compared with those included in the current data analysis . of 4,482 participants in the 2006 qingdao diabetes survey , 1,294 attended the follow - up survey in 2009 . participants did not differ much from nonparticipants in age ( 49.3 years [ 95% ci 48.849.8 ] vs. 48.9 years [ 48.649.3 ] ) , fpg ( 5.37 mmol / l [ 95% ci 5.335.41 ] vs. 5.41 mmol / l [ 6.416.53 ] ) , or family history of diabetes ( 16.9 vs. 17.0% , p = 0.923 ) , but the participants in the follow - up study had slightly higher bmi ( 25.9 kg / m [ 95% ci 25.726.1 ] vs. 25.4 kg / m [ 25.325.5 ] ) and higher systolic blood pressure ( 133.3 mmhg [ 95% ci 132.3134.4 ] vs. 130.7 mmhg [ 130.0131.4 ] ) but a lower proportion of men ( 34.3 vs. 39.3% , p = 0.002 ) . baseline characteristics of participants in the china national diabetes and metabolic disorders study ( exploratory population ) , qingdao prospective study 20062009 ( validation 1 ) , and qingdao cross - sectional survey 2009 ( validation 2 ) in the multivariable logistic regression analysis , increased age , male sex , bmi , waist circumference , systolic blood pressure , and positive family history of diabetes in a first - degree relative were significantly associated with the presence of undiagnosed type 2 diabetes ( table 2 ) . the hosmer - lemeshow test showed that the predicted prevalence of undiagnosed type 2 diabetes of the multivariable model matched well with the observed prevalence (  = 6.99 , p = 0.537 ) . addition of bmi and systolic blood pressure into the multivariable model fitted with age , sex , waist circumference , and family history of diabetes improved the reclassification of the predicted probabilities of the model ( net reclassification improvement = 0.048 , p < 0.001 ) . odds ratio ( 95% ci ) and -coefficient for prevalence of previously undiagnosed diabetes in the 41,809 participants of the exploratory population , estimated using logistic regression analysis the risk score was developed based on the multivariable model ( table 2 ) . a total of 17,704 ( 42.3% ) participants in the exploratory population had a risk score 25 , and 2,097 ( 11.8% ) had diabetes . the aucs of the roc curve were 0.748 ( 95% ci 0.7390.756 ) in the exploratory population . the aucs of the new chinese diabetes risk score for predicting incidence of type 2 diabetes based on validation 1 were 0.725 ( 955 ci 0.6830.767 ) , 0.635 ( 0.5660.705 ) , and 0.770 ( 0.7150.824 ) in all individuals , men , and women ; they were 0.702 ( 0.6800.724 ) , 0.678 ( 0.6430.713 ) , and 0.717 ( 0.6880.747 ) , respectively , for detecting the prevalence of undiagnosed type 2 diabetes based on validation 2 . a total of 789 ( 67.9% ) individuals in validation 1 and 2,754 ( 64.4% ) in validation 2 had a risk score 25 points . at the cutoff point 25,the sensitivity and specificity were 92.3 and 35.5% in validation 1 and 86.8 and 38.8% in validation 2 , respectively . at a cutoff point 30 , moderate sensitivity ( 75.4% in validation 1 and 67.8% in validation 2 ) and specificity ( 57.8% in validation 1 and 61.2% in validation 2 ) were achieved . in the sensitivity analysis separately for men and women , age , bmi , waist circumference , systolic blood pressure , and family history of diabetes remained in the final model in both sexes . the auc for men ( 0.731 [ 0.7180.745 ] vs. 0.729 [ 0.7160.743 ] ) and women ( 0.758 [ 0.7460.770 ] vs. 0.757 [ 0.7450.769 ] ) was not different from that derived from the model combining both men and women in the exploratory population . the second sensitivity analysis by limiting the age of the exploratory population to 3574 years was performed among 11,941 men and 18,918 women ; mean ( sd ) age of both was 50 ( 10 ) years . the risk - assessment algorithm derived from the second sensitivity analysis comprised basically the same risk factors as the new chinese diabetes risk score except for an additional variable of the educational level , and both performed equally well regarding the auc in the validation databases ( auc 0.725 [ 0.6830.767 ] in validation 1 and 0.701 [ 0.6790.724 ] in validation 2 ) . discrimination of the new chinese diabetes risk score was compared with 10 scores derived from other populations that were applicable to validation 1 and validation 2 ( table 3 and fig . the performance of the new chinese diabetes score is superior to other existing risk scores in terms of aucs . performance of the new chinese diabetes risk score and other published scores for predicting incidence of diabetes ( validation 1 ) and for detecting the prevalence of undiagnosed diabetes ( validation 2 ) performance of various risk scores for predicting incidence of diabetes ( a  c ) and detecting prevalence of undiagnosed diabetes ( d  f ) based on external validation . f : women in validation 2 . a and d :  , the new chinese diabetes risk score ;  , rotterdam pm1 ;  , inter99 ;  , indian risk score ;  , thai risk score ;  , american diabetes association recommendation ;  , oman risk score ;  , a new risk score in the u.s . b , c , e , and f :  , the new chinese diabetes risk score ;  , data from the epidemiological study on the insulin resistance syndrome ( desir ) ;  , qingdao diabetes risk score ;  , mauritian indian risk score . the new chinese diabetes risk score for detecting undiagnosed type 2 diabetes comprising of age , sex , waist circumference , bmi , family history of diabetes , and systolic blood pressure was developed based on data of the china national diabetes and metabolic disorders study . the performance of the new chinese diabetes risk score is adequate regarding the detecting and predicting type 2 diabetes in the chinese population and performs better than most of the existing risk scores for detecting undiagnosed type 2 diabetes in the validation population of the qingdao cross - sectional survey in 2009 . several risk scores for predicting ( 12,14,15,17 ) or detecting ( 711,13,16,25 ) undiagnosed type 2 diabetes have been developed ; most of these were derived from caucasian populations ( 814 ) and a few from asian populations ( 7,1517,25 ) . the common risk factors involved in the scores were age , family history of diabetes , and anthropometric indicators of obesity . the aucs of these existing risk scores for type 2 diabetes ranged from 0.62 to 0.80 in the original population . most of these existing risk scores performed better in their original population than in the two chinese validation populations , indicating that a race- or country - specific risk score may be needed . compared with another chinese risk score derived from chinese living in qingdao ( 7 ) , two more risk factors including bmi and systolic blood pressure were added to the new risk score we developed , which improved the performance of the prediction significantly . blood pressure is usually measured by health care providers during a clinic visit or periodic health check - up in china . the new chinese diabetes risk score can be introduced to the health care providers or added to a check - up program to increase the chance for type 2 diabetes screening in health care settings . for people who can measure blood pressure at home , the risk score can also be applied to lay populations . because a blood pressure monitor is not available in most families in china as well as in some remote areas with scarce medical resources , the qingdao diabetes risk score can be applied to the families and regions where blood pressure measure is not available . the strength of the current score is that it is developed based on data of the large national representative sample and validated in two external population - based studies . but many questions that were included in other published risk scores such as  delivery of a macrosomic infant  ( 11 ) ,  if steroids are used  ( 10 ) , or  daily consumption of vegetables , fruits , or berries  ( 12 ) were not available in our study questionnaire . to what extent these missing variables will affect the prediction of the risk score is unclear . moreover , although using the new chinese diabetes risk score to screen type 2 diabetes may reduce the number of individuals undergoing an ogtt , it will miss people with type 2 diabetes too . the new chinese diabetes risk score gave a low specificity at the optimal cutoff value . the choice of a cutoff value depends on the purpose of applying the risk score . as an effective and cheap health promotion tool instead of a diagnostic test , the risk score can reach a large lay population in a short time period , spreading through media , internet , school children , working places , and primary care clinics . as a consequence of the widespread use of the risk score , the public awareness of diabetes and its risk factors that bear on the risk score sheet raised significantly , as shown by our previous work in qingdao , china ( 26 ) . these had little influence on the results as shown in the sensitivity analyses . in the current study , the new chinese diabetes risk score was validated in two chinese populations living in qingdao ; further validation of the risk score in other parts of china is needed considering the large diversity of the chinese population . in conclusion , the new chinese diabetes risk score shows an adequate performance regarding the prediction and detection of type 2 diabetes in china and provides an alternative to the existing simple chinese diabetes risk score .
objectiveto develop a new chinese diabetes risk score for screening undiagnosed type 2 diabetes in china.research design and methodsdata from the china national diabetes and metabolic disorders study conducted from june 2007 to may 2008 comprising 16,525 men and 25,284 women aged 2074 years were analyzed . 
 undiagnosed type 2 diabetes was detected based on fasting plasma glucose 7.0 mmol / l or 2-h plasma glucose 11.1 
 mmol / l in people without a prior history of diabetes . 
 -coefficients derived from a multiple logistic regression model predicting the presence of undiagnosed type 2 diabetes were used to calculate the new chinese diabetes risk score . 
 the performance of the new chinese diabetes risk score was externally validated in two studies in qingdao : one is prospective with follow - up from 2006 to 2009 ( validation 1 ) and another cross - sectional conducted in 2009 ( validation 2).resultsthe new chinese diabetes risk score includes age , sex , waist circumference , bmi , systolic blood pressure , and family history of diabetes . 
 the score ranges from 0 to 51 . 
 the area under the receiver operating curve of the score for undiagnosed type 2 diabetes was 0.748 ( 0.7390.756 ) in the exploratory population , 0.725 ( 0.6830.767 ) in validation 1 , and 0.702 ( 0.6800.724 ) in validation 2 . at the optimal cutoff value of 25 , the sensitivity and specificity of the score for predicting undiagnosed type 2 diabetes were 92.3 and 35.5% , respectively , in validation 1 and 86.8 and 38.8% in validation 2.conclusionsthe new chinese diabetes risk score based on nonlaboratory data appears to be a reliable screening tool to detect undiagnosed type 2 diabetes in chinese population .