a 65-year - old female visited wonkwang dental university hospital for the removal of a bony dysplastic lesion in the left maxilla . this lesion has been regularly examined in follow - up for the last 14 years . on clinical examination , , she visited our dental hospital for treatment of a periodontal condition on the entire dentition . she had already recognized bony swelling on the left maxilla decades ago , but recalled no experience of pain or fever . her medical history did not contain anything of significance . computed tomography in 2002 showed a ground - glass appearance of the left maxilla , which was compatible with fd ( fig . 2 ) . bucco - lingual cortical expansion , but no cortical destruction , was observed . she refused surgical treatment due to a fear of surgery and felt no need for it , since there was no pain and the lesion was not increasing in size . 3 ) showed a diffuse , widespread , radiopaque lesion in the left maxilla and maxillary sinus . a periapical view in 2007 showed a ground - glass appearance and indistinct anterior border of the lesion . 4 ) . in 2008 , we performed bone scintigraphy using tc - methylene diphosphonate ( tc - mdp ) for detecting the distribution of the lesion . a whole - body bone scan showed intense uptake of radioisotope in the left maxilla ( fig . figure 5b shows mild uptake of radioisotope in the vascular and blood pool phase , and intense uptake in the delayed bone scan . blood pool images were acquired immediately after the flow portion of the study and completed within 10 minutes of tracer injection , for approximately 3.5 minutes / image . routine delayed images are usually obtained 2 - 5 hours after injection . the panoramic view ( fig . 6a , 2016 ) showed a similar image of the lesion , compared with older images ( fig . 6b , 2012 ; 7a and b ) in 2016 showed a similar image and no change in size when compared with older images ( figs . 2 ) . a ground - glass appearance , expanded cortex , no tooth displacement , and slight involvement of the maxillary sinus were common findings . excision of the fd was carried out and a surgical specimen was sent for histopathological examination . microscopic examination of the excised specimen showed irregularly shaped woven bone with peritrabecular clefting within a cellular fibrous stroma . it has been reported that fd represents approximately 5% to 7% of all benign bone tumors.12 occurrences of fd present in 3 forms that are monostotic ( including craniofacial ) , polyostotic , and polyostotic with endocrinopathies . the monostotic form accounts for 80% to 85% of cases with fd,7 and is not a precursor of the polyostotic form.13 the occurrence of fd is found predominantly in children and young adults , with 75% of patients presenting before the age of 30.1415 cases in female patients have been observed more frequently in their later decades.16 monostotic fd of the jaws more commonly involves the maxilla than the mandible,1617 but another study has reported that the mandible was more frequently involved.8 due to the gradual and painless nature of fd , the clinical findings are usually asymptomatic . if the fd extends into sphenoid , orbital , or frontal bones , complications may include proptosis , visual disturbances , and hearing loss.18 in this case , the patient presented with monostotic fd that was localized to the left side of the maxilla , which caused alveolar bone expansion and facial asymmetry . the natural progression of fd includes 2 phases : an active phase , which persists until puberty , and a subsequent phase.1920 many reports have shown that fd progresses slowly or ceases after bone maturation . however , the range in the literature is wide - in some cases it does not progress after puberty,921 while in other cases it continues to progress in old age.2223 polyostotic fd is more likely to continue to progress even after puberty.12 the present report is focused on fd manifesting in an elderly female patient , which is rare . this case might have been a slow growing lesion in the beginning , which then entered into a quiescent stage in adulthood . we postulated that the patient might not have noticed the severity of this lesion until middle age . remodeling of bone to normal lamellar type does not happen in the dysplastic bone of fd . thus , this bone is likely to be vulnerable to stimulation , which may reactivate it.7 some cases of reactivation in later stages of life have also been reported.1011 the possible mechanisms of reactivation are trauma , hormonal changes , trauma - included accident , surgery , or tooth extraction.24 another study of fd that activated or reactivated in pregnant women proposed that female sex hormones are important in the high recurrence rate of fd of the jaws for female patients.725 some previous studies have reported that there is a very small risk for malignant transformation.26 the risk for malignant transformation is estimated at less than 1% in the monostotic form and at maximally 4% to 6.7% in the polyostotic form;2728 this is less prevalent in patients who have not undergone radiation therapy.28 the current gold standard for the diagnosis of fd is a histologically proven fibro - osseous lesion with poorly defined margins , and definite diagnosis relies on radiographic findings.7 the abnormal trabeculae are usually shorter , thinner , irregularly shaped , and more numerous than normal trabeculae . these abnormal trabeculae and the homogenous radiodensity account for the  ground - glass  appearance in fd.32930 fd affecting the maxilla almost always involves the antrum , either by obliterating it or by gross displacement of its borders.8 the fd extension in this case was directed horizontally , but also slightly vertically . in this growth direction the floor of the left maxillary sinus appeared slightly occupied . the loss of lamina dura was unique to fd and could be used as another diagnostic feature for fd.31 bone scintigraphy , using tc - mdp is exquisitely sensitive for detecting fd lesions.32 it is a useful imaging modality for detecting the distribution of lesions , and scintigraphy has been evaluated for discriminating between monostotic and polyostotic disease , ruling out metastasis of secondary sarcoma , and recurrence after therapy.33 monostotic fd , especially in the bones of the skull , generally appears as an area of markedly increased uptake reflecting hyperemia as well as osteoid matrix , with a particularly intense homogenous uptake pattern in the delayed phase.34 the bone scintigraphy in this study showed intense uptake of delayed bone phase although perfusion and blood pool phases showed mild uptake . we think intense uptake of delayed bone phase is due to the increased surface area of fibrous - degenerative bone , rather than the increased vascularity and osteoblast activity of the lesion . our case showed fd in the left maxilla of a more than 14-year duration with almost the same size . this report emphasizes a case of a hamartomatous nature , involving the quiescent stage of fd in an elderly patient . our evaluation is that this case ceased to grow in early adulthood , when skeletal maturity had been reached . a literature review on the disease activity of fd suggests that reactivation of fd could be possible due to many factors , but most cases remain in the quiescent stage , and malignant transformation is very rare in monostotic fd .
fibrous dysplasia ( fd ) is an uncommon skeletal disorder in which normal bone is replaced by abnormal fibro - osseous tissue . 
 mainly , fd is found in children , and by adulthood it usually becomes quiescent . 
 our case showed fd of more than 14-year duration in the left maxilla . 
 our evaluation was that growth ceased in adulthood and had achieved the static stage . 
 because fd cases in elderly patients are rarely reported , we hereby present a monostotic fd case in a 65-year - old female . 
 we presented sequential radiographic images and scintigraphic images of this case , and combined them with a literature review that emphasized the progression of the disease .