the use of osseointegrated implants to support prosthetic reconstructions has become a common treatment modality for partial and complete edentulous patients . the early studies of brnemark et al1,2 and schroeder et al3,4 have been the pioneering clinical studies . they have discovered a direct bone - to - implant contact referred as osseointegration and obtained encouraging long term results in fully edentulous patients.5,6 the original brnemark concept was based on the rehabilitation of edentulous mandible with four or six implants inserted in intraforaminal zone and the implants were connected to each other with a fixed full - arch prosthesis with distal cantilevers , known as toronto bridge. in the last two decades , the original brnemark concept has been greatly modified . there have been many advances in surgical and prosthetic protocols , as well as in implant materials , surfaces and forms . all these factors have broadened the applicability of implants and clinical guidelines have been established for predictable results . now they are being used nearly in all fields of dentistry ; in the treatment of partial and complete edentulism , in craniofacial surgery , and in orthodontics as anchorage device.2,611 the first clinical studies reporting the success of osseointegrated implants were retrospective studies of completely edentulous arches treated with brnemark implants.5,6 the authors reported survival rates of 86% in mandible and 78% in the maxilla after 15 years of function . in course of time , many prospective studies were designed to examine the results of osseointegrated implants restored with fixed or removable prosthesis in edentulous arches.1214 in a study , ferrigno et al15 evaluated the long term prognosis of 1286 non - submerged iti implants in fully edentulous arches and reported a cumulative survival rate of 95.9% and a cumulative success rate of 92.7% in ten years . recently , astrand et al16 reported 99.2% survival rate in edentulous arches after 20 years of function . the successful outcome of the research that had been conducted in fully edentulous patients encouraged the clinicians to use the implants in the treatment of every kind of edentulism . in a prospective cohort study bornstein et al17 examined 104 osseointegrated implants in 51 partially edentulous patients and reported 99% survival and success rate at the end of 5 years of function . similarly romeo et al18 reported a cumulative survival rate of 99.35% and cumulative success rate of 96.18% for single tooth restoration in 5 years of function . the results of meta analysis studies and many other clinical studies show that osseointegrated implants as anchors for various prosthetic reconstructions are a predictable treatment alternative for long term.1924 the purpose of this retrospective study was to evaluate the clinical performance of non - submerged implants placed in the maxilla or in the mandible over a period of 5 years . 448 patients who were treated by the authors and received implant - supported / retained prostheses were screened for the study . the inclusion criteria for enrollment in this study were ( 1 ) age between 18 and 65 years , ( 2 ) the presence of any kind of maxillary or mandibular edentulism ( single tooth gap , distal extension , edentulous space in the ark , single tooth gap , fully edentulous ) , ( 3 ) sufficient bone volume at the surgical site ( minimum bone height of 7 mm ) as assessed by clinical and radiological examination , ( 4 ) the absence of periodontal and mucosal diseases , and ( 5 ) good general health status . of 102 recruited potential subjects , 60 were excluded for the presence of systemic diseases and radiation therapy because such conditions may complicate and/or contraindicate surgery and osseointegration . the final group of subjects enrolled in the study included 42 ( 20 women , 22 men ) who had 146 implants installed in their maxillae and/or mandibles . the mean age of the enrolled patients at the time of implant placement was 48 years ( range 20 to 66 years ) . the patients presented with one of five different indications ( single tooth gap , distal extension , edentulous space in the ark and fully edentulous ) . iti implants ( international team for implantology , straumann ag , waldenburg , switzerland ) were used in all cases . implants with lengths of 8 , 10 , 12 or 14 mm and diameters of 3.3 , 4.1 or 4.8 mm were used . all implants were installed by the same surgeon from the istanbul university faculty of dentistry department of oral surgery . the prostheses were fabricated by the same prosthodontist at the department of maxillofacial prosthodontics at istanbul university . of the 146 implants examined here , 55 ( 37.67% ) were placed in the maxilla , including 22 that were placed in anterior positions ( 5 in females , 17 in males ) and 33 that were placed in posterior positions ( 17 in females , 16 in males ) . meanwhile , 91 ( 62.33% ) implants were placed in the mandible , including 29 that were placed in anterior positions ( 18 in females , 11 in males ) and 62 that were placed in posterior positions ( 48 in females , 14 in males ) . a total of 87 prosthetic restorations were connected to the implants ( table 2 ) . the surgical technique complied with the general guidelines defined by brnemark et al25 and the specific indications recommended by buser et al26 and by buser and maeglin27 for iti implants . none of the implants included in this study were placed immediately after an extraction or loaded immediately after implant placement . bone quality classification was performed at the time of surgery by the oral surgeon on the basis of hand - feeling persistence of the drilling resistance according to the classification of trisi and rao.28 implants placed in sites with good bone quality ( dense , normal ) were examined after a healing period of two months in the maxilla or six weeks in the mandible . implants placed in sites with poor bone quality ( soft ) were examined after a three - month healing period . the maxillary full - arch bridges were retained by implants placed in positions 11 - 13 - 15 - 16 - 21 - 23 - 25 - 26 and the mandibular in positions 33 - 34 - 35 - 36 - 43 - 44 - 45 - 46 . patients who were treated with overdenture supported with dolder bars received the implants positioned in mandible 34 - 32 - 42 - 44 , in maxilla 14 - 12 - 22 - 24 . none of the overdentures in maxilla was supported with ball anchors . at follow - up examinations , the implants were examined for tissue integration according to the strict parameters defined by buser et al.29 specifically , the integration was considered successful if the following parameters were met : ( 1 ) absence of recurring peri - implant infection with suppuration ; ( 2 ) absence of persistent subjective complaints such as pain , foreign body sensation , and/or dysesthesia , ( 3 ) absence of a continuous radiolucency around the implant , and ( 4 ) absence of any detectable implant mobility . these criteria have proven to be effective in defining the success of an implant system and evaluating long - term results in clinical trials . all implants were subsequently assessed clinically and radiographically at seven follow - up examinations which occurred 1 , 6 , 12 , 18 , 24 , 48 and 60 months after prosthesis placement . radiographic evaluation was performed by either periapical radiographs obtained by long - cone paralleling technique or panoramic radiographs . in patients who were treated with overdentures or full - arch bridges supported with multiple implants mesial and distal bone levels of each implant were measured with a transparent millimeter ruler and the measurements were compared with those recorded at the baseline measurement . because of the relatively small sample size of the study population , statistical analysis of the data regarding marginal bone level loss was not performed . a qualitative evaluation based on the implant success criteria defined by buser et al29 the patients were also evaluated for symptoms of pain , prosthesis mobility and evidence of infection and any adverse reaction reported by the patients was also recorded . the statistical analysis was performed at the beginning of 2007 according to the life table analysis described by cutler and ederer.30 life tables included the following parameters : observation time , number of implants at the start of each interval , number of failed implants during each interval , number of implants not subjected to follow - up examination due to patient drop - out , annual survival and success rates and cumulative survival and success rates . cumulative success rates , which took into account failure conditions in addition to failed implants , were calculated for each jaw . the formula used for the calculations in this study is as follows : ( csr : cumulative success rate , pcsr : previous cumulative success rate , isr : interval success rate ) the statistical analysis was performed at the beginning of 2007 according to the life table analysis described by cutler and ederer.30 life tables included the following parameters : observation time , number of implants at the start of each interval , number of failed implants during each interval , number of implants not subjected to follow - up examination due to patient drop - out , annual survival and success rates and cumulative survival and success rates . cumulative success rates , which took into account failure conditions in addition to failed implants , were calculated for each jaw . the formula used for the calculations in this study is as follows : ( csr : cumulative success rate , pcsr : previous cumulative success rate , isr : interval success rate ) of 448 implant patients treated by the authors , 102 patients were included in the study . of these 102 recruited potential subjects , 60 were excluded for the presence of systemic diseases and radiation therapy . finally 42 ( 20 women , 22 men ) subjects who had 146 implants installed in their maxillae and/or mandibles were enrolled in the study . the mean age of the patients at the time of implant placement was 48 years ( range 20 to 66 years ) . the patients presented with one of five different indications ( 48 single tooth gap , 38 distal extensions , 30 edentulous spaces in the ark , 30 fully edentulous ) . 74.02% of single and multiple - unit implant retained bridges were cemented and 26.08% were screw retained . of the 146 examined implants , 4 ( two in anterior maxilla , one in posterior maxilla , one in posterior mandible ) did not integrate before loading and revealed peri - implant infection with suppuration . we considered these as early failure and this resulted in 2.74% early failure rate ( tables 3 and 4 ) . these implants were replaced with new implants 3 months after the implant removal and demonstrated complication free hard and soft tissue integration . four implants were surgically removed during the 5-year follow - up period , primarily due to recurrent peri - implant infection ( table 3 ) . the remaining implants osseointegrated in bone and did not show signs of peri - implant infection and/or peri - implant radiolucencies . the most common ( 3.42% ) prosthetic complication was abutment and screw loosening ( table 5 ) . the cumulative one - year survival rates of implants were 97.37% for the maxilla and 97.80% for the mandible . the five - year success rates were 90.90% for both the anterior and posterior maxilla . the five - year success rates were 100% for the anterior mandible and 96.72% for the posterior mandible . hence , the life analysis indicated that the 5-year functioning cumulative success rates were 90.90% for maxillary implants and 97.80% for mandibular implants . this study retrospectively examined a cohort of 42 patients who presented with a variety of indications in both jaws over a 5-year period and confirmed good performance of the iti dental implant system in the treatment of edentulism that was consistent with previously reported short - term and long - term success and survival rates of the system.15,18,31,32 the quality of an implant system must be judged scientifically . since 1978 , several criteria schemes proposed for assessing implant success have been proposed , beginning with the first success criteria scheme described by the national institutes of health in 197833 followed by albrektsson et als34 and buser et als29 progressively stricter schemes in 1986 and 1990 . as elaborated in the methods , here we used buser et als29 strict parameters for evaluating implant system success and long - term clinical trial results . life table analysis performed according to the recommendations of cutler and ederer30 proved to be an appropriate and rather conservative statistical method for examining the long - term success and survival rates of osseointegrated implants.15,31 this study revealed a distinction between implant survival and success according to the defined criteria . consistent with prior reports , we observed greater success rates for mandibular implants than for maxillary implants.18,26,31 while our 5-year functioning cumulative success rate for mandibular implants ( 97.80% ) was consistent with the literature , our 5-year functioning cumulative success rate for maxillary implants ( 90.90% ) was lower than that reported previously . in a large multi - center prospective study , buser31 reported a 5-year success rate of 97.30% ( 13 failures/488 implants ) and 5-year survival rate of 98.20% ( 9 losses/488 implants ) in the maxilla . the slightly lower rate observed for maxillary implants here is most likely related to the status of the recipient sites , as only 32.8% of the implants were placed in standard sides . advanced surgical techniques , such as guided bone regeneration and sinus floor augmentation , may be used to increase the bone volume and enable the placement of dental implants in atrophic ridges , but they present greater risks compared to standard sides and demonstrate lower success rates.36,37 weber35 did not consider the status of implant recipient side . among the 146 implants studied here , the three failed implants reported here were not associated with any clinical signs of peri - implant infection with suppuration . our low early failure rate was consisted with those previously reported.18,32 early failure of the implants in these cases may have been caused by bone necrosis due to overheating of the peri - implant bone during the preparation of implant bed . it is worth noting that in all three of these cases , the implants were located in the posterior maxilla at sites with poor bone quality and sinus floor elevation . the primary reason for surgical removal of the four removed implants was recurrent peri - implant infection . the most important factor in the reliability of the results of clinical studies reporting success and survival rate is that they should have a predefined , strict protocol with at least five years of clinical documentation from which drops - outs , failures , success and survival rates in the initial sample groups can be extrapolated . although the present study did not employ a prospective design , the reliability of the data is enhanced given then only implants that were placed following a strict protocol ( routine clinical and radiographic controls ) and followed for a full 5 years were included . while our requirement for use of a strict protocol was important for improving data reliability , it did ultimately reduce the sample number relative to prior research reporting success and survival rates for periods of at least 5 years.31 within the limitations of the observation period and sample number , the present findings confirmed sufficient success and survival rates of iti implants placed in mandible as well as implants placed in the maxilla .
objectivesthe use of osseointegrated implants as an endoestal anchorage device to provide support for dental prostheses is a reliable and widely accepted treatment modality.the purpose of this study was to evaluate the clinical performance of non - submerged implants placed in the maxilla or in the mandible.methodsa total of 146 international team for implantology ( iti ) ( straumann ag , waldenburg , switzerland ) implants were placed in 42 patients ( 20 women , 22 men , mean age 42 ) . 
 the cases were examined retrospectively in order to evaluate the clinical efficiency of non - submerged iti implants and to determine the success rate of implant retained / supported prosthesis after a 5-year period . 
 all implants were assessed clinically and radiographically on a yearly basis.resultsthe 5-year cumulative success rates for maxillary and mandibular implants were 91.00% and 97.81% , respectively . 
 the most common prosthetic complication was abutment accompanied by screw loosing ( 3.42% ) . 
 veneering material fracture was documented in only one patient.conclusionswithin the limitations of the observation period and sample number , the present findings confirmed sufficient success and survival rates of iti implants placed in mandible as well as implants placed in the maxilla after a 5-year period .