sialolipoma is a rare tumor of salivary glands , described in 2001 by nagao et al . it is a benign lipomatous neoplastic growth of the salivary glands with mature adipose tissue . sialolipoma occurs in the minor and major salivary glands with an unpredictable and potentially aggressive behavior . treatment of sialolipoma includes total parotidectomy for deep lobe involvement and superficial parotidectomy in tumor of outer lobes , with preservation of the facial nerve as in benign neoplasms of salivary glands . the aim of this article is to report two new cases of sialolipoma and discuss the clinico - pathologic features , differential diagnosis , and histopathological findings of the lesions . a thorough review of the available english literature revealed only 17 cases of sialolipoma arising in the minor salivary glands and 19 cases in major salivary gland with no recurrences . a 45-year - old female presented with a painless mass in the right parotid gland . a course of antibiotic therapy had been prescribed to rule out infection causes without any beneficial effect . an ultrasound imaging showed a relatively solid hypoecho nodule in the right parotid gland at the superficial lobe [ figure 1 ] . superficial parotidectomy was done , superficial lobe with tumor was freely separated from adjacent tissue . the gross specimen contained a soft , brown - yellowish lobulated mass with definitive borders measuring 7.5  5  2.5 [ figure 2 ] . the ratio of mature adipose tissue to salivary gland tissue was 2:5 [ figure 3 ] . a one - year follow - up period showed no evidence of recurrence [ figure 4 ] . a solid hypoecho nodule in right superficial parotid lobe gross examination showing a soft yellowish lobulated mass microscopically , the lesion composes of mature adipose tissue with atrophic salivary glands ( h and e staining ) clinical photograph : a one year follow - up period showing no evidence of recurrence an 18-year - old female was admitted to the ghaem hospital , mashhad , iran , with a one - year history of painless swelling in the left parotid region . clinical examination showed a soft movable mass approximately 6 cm  5 cm in size . histopathologic examination revealed a well - defined lobular structure , containing mature fatty tissue , within salivary gland element . the ratio of mature adipose tissue to salivary gland tissue was 1:3 [ figure 6 ] . ultrasonography of the left parotid region showing a hypoechoic mass histopathologic examination showing adipose tissue with salivary gland structure ( h and e staining ) a 45-year - old female presented with a painless mass in the right parotid gland . a course of antibiotic therapy had been prescribed to rule out infection causes without any beneficial effect . an ultrasound imaging showed a relatively solid hypoecho nodule in the right parotid gland at the superficial lobe [ figure 1 ] . superficial parotidectomy was done , superficial lobe with tumor was freely separated from adjacent tissue . the gross specimen contained a soft , brown - yellowish lobulated mass with definitive borders measuring 7.5  5  2.5 [ figure 2 ] . the ratio of mature adipose tissue to salivary gland tissue was 2:5 [ figure 3 ] . a one - year follow - up period showed no evidence of recurrence [ figure 4 ] . a solid hypoecho nodule in right superficial parotid lobe gross examination showing a soft yellowish lobulated mass microscopically , the lesion composes of mature adipose tissue with atrophic salivary glands ( h and e staining ) clinical photograph : a one year follow - up period showing no evidence of recurrence an 18-year - old female was admitted to the ghaem hospital , mashhad , iran , with a one - year history of painless swelling in the left parotid region . clinical examination showed a soft movable mass approximately 6 cm  5 cm in size . histopathologic examination revealed a well - defined lobular structure , containing mature fatty tissue , within salivary gland element . the ratio of mature adipose tissue to salivary gland tissue was 1:3 [ figure 6 ] . ultrasonography of the left parotid region showing a hypoechoic mass histopathologic examination showing adipose tissue with salivary gland structure ( h and e staining ) sialolipoma is a rare , recently recognized entity with only 36 cases published so far . microscopically , this lesion characterizes with mature adipose tissue and non - neoplastic salivary gland tissue . atrophy of the glandular structures , ductal dilation with scattered foci of fibrosis , sebaceous and squamous metaplasia , oncocytic changes , myxoid islands , lymphocyte infiltration , inside the lipomatous proliferation are also present . lipoma usually contains mature encapsulated fatty cells , but sialolipoma has salivary gland elements between adipose tissue . fine needle aspiration ( fna ) is not an appropriate biopsy technique for diagnosis of sialolipoma , because both fatty and salivary gland tissues are not dysplastic . sakai reported a hard plate mass with a hypointensity in t1 and isointensity in t2 images . thirty - six cases of sialolipoma published in english language reports were analyzed considering gender , age , location , size , duration of symptoms , treatment mode , follow - up , and histologic findings [ tables 1 and 2 ] . minor salivary gland tumors were in hard plate ( 5 cases ) , floor of the mouth ( 3 cases ) , buccal mucosa ( 2 cases ) , soft plate ( 2 cases ) , buccal sulcus ( 1 cases ) , tongue ( 2 cases ) , lower lip ( 1 cases ) , and retromolar pad ( 1 case ) . in this group summary of clinicopathological features of minor salivary gland summary of clinico - pathological features of major salivary gland nineteen cases of sialolipoma were reported in major salivary glands without our cases [ table 2 ] . fourteen cases have been reported in the parotid gland and 5 cases in the sub - mandibular gland . there were only two cases of deep lobe involvement , and other cases were seen in superficial lobe . based on table ii , most patients were in their fourth decade of life and above with a slight male predilection . symptoms were present for a long time , from 2 months to 11 years [ table 2 ] . tumor size was larger in major salivary glands , although large lesions , up to 4 cm in the largest diameter , were reported in minor salivary glands . recommended treatment of parotid sialolipoma , is surgery with preservation of facial nerve . only two cases were treated with total parotidectomy , while other cases were treated by superficial parotidectomy with preservation of facial nerve . fine needle aspiration ( fna ) is not an appropriate biopsy technique for diagnosis of sialolipoma , since the lesion contains mature adipose tissue and non - neoplastic salivary gland tissue .
sialolipoma is a rare neoplasm of salivary glands , described as a distinct entity by nagao et al . in 2001 
 . 
 thirty - six cases of sialolipoma in minor and major salivary glands have been reported thus far in addition to the two new cases of sialolipoma arising in the major salivary glands in this study . 
 thirty - six cases of sialolipoma published in english language reports were analyzed considering gender , age , location , size , duration of symptoms , treatment mode , follow - up , and histologic findings . 
 congenital sialolipomas were considered in this study . 
 the first case occurred in a 45-year - old female and presented as a localized swelling in right parotid area . 
 the second case occurred in an 18-year - old female as a swelling in the left parotid region . 
 on histopathological examination , these lesions were diagnosed as sialolipoma .