recently , renal artery stenosis ( ras ) incidence increased , reflecting widespread atherosclerosis in a population with extensive comorbidity burden.1 simultaneous atherosclerotic determinations in at least 2 major territories are common and managed as multisite artery disease.2 this complexity of artery determinations generates a variety of clinical scenarios ( major adverse cardiac events [ mace ] , stroke , peripheral artery disease [ pad ] , endstage renal disease ) , raising difficulties in approaching diagnostic and treatment algorithms.3 thus , when a significant atherosclerotic lesion is discovered following a vascular event , it is justified to identify other sites where this disease could silently manifest . screening algorithms for a second site need to be developed and assessed , since there is a greater risk of complications and recurrent symptoms for the first lesion.4 
  ras has a higher prevalence in patients with concomitant pad or coronary artery disease ( cad).5 data obtained using cardiac catheterization and simultaneous renal angiography ( ra ) showed that ras is present in 15% to 20% of cad patients.6 , 7 , 8 , 9 all previous studies reported data on ras prevalence in nonemergency cad . there are no data reporting ras prevalence in patients presenting with acute myocardial infarction ( ami ) . these patients may have a particular inflammatory , metabolic , and endothelial profile , which could be associated with a higher ras incidence . arterial stiffness is an important cardiovascular risk factor and an independent predictor of cardiovascular morbidity and mortality10 in patients with hypertension,11 diabetes mellitus,12 and chronic kidney disease ( ckd).13 pulsedwave velocity ( pwv ) , as a measure for arterial stiffness , is an independent predictor of primary coronary events,14 and also a strong predictive factor for mace postami,15 but no studies have been published evaluating the discriminatory power of pwv in ras versus nonras ami patients . fluid balance is often modified in ras patients.16 recent data suggest that dehydration could be a trigger for ami17 and a predictor of death postami.18 there are no studies evaluating hydration status in ami patients with ras , both entities being characterized by a complexity of neurohumoral responses . we aimed ( 1 ) to evaluate ras prevalence in consecutive ami patients from a single tertiary center ; ( 2 ) to evaluate for the first time the hydric and metabolic status in ras ( versus nonras ) ami patients ; ( 3 ) to assess vascular stiffness ; ( 4 ) to elaborate a multivariate model that could predict ras ; and ( 5 ) to propose an accurate screening standard for ras in ami . in a followup study , we plan to examine the impact of ras and stiffness on ami shortterm and longterm outcome ( clinicaltrials.gov protocol nct02388139 ) . between october 2014 and march 2015 , all consecutive patients with ami included in romanian national program of primary percutaneous revascularization were enrolled in our prospective , nonrandomized singlecenter study ( renacs ) . the  gr .  t. popa  iasi university ethics committee approved the protocol . all patients were admitted for emergency percutaneous coronary intervention ( pci ) and treated following european standard protocols.19 in the same procedure we performed diagnostic ra . on the basis of clinical examination and interview defined previously20 ( adapted after the european cards registration data standards ) , we obtained data on the following : medical history ( relevant to cad and ras  previous pci , ckd , chronic heart failure , and pad ) , cardiovascular risk factors ( smoking , dyslipidemia , diabetes mellitus , hypertension ) , and killip class . cardiac echography was performed prior to angiography . in the first 24  hours postpci we assessed bioimpedancederived parameters and arterial stiffness . we performed coronary angiography via right femoral artery and treated coronary lesions ( thrombus aspiration , coronary stenting ) as usual.19 therapeutic decisions were not influenced by study requirements . after coronarography , ra was performed by selective injection of 10  ml contrast medium through a 6f diagnostic catheter in renal arteries . coronarographic lesions were assessed and reported during the procedure . after the pci procedure , all patients received standard intravenous and oral hydration fluids ( 500 to 1000  ml saline iv and 1000  ml water , respectively ) . ra images were analyzed offline in the first 24  hours by 2 independent operators , using angiographic software tools . using the catheter as a scaling device , percent diameter stenosis and renal diameters were computed ( philips allura xper fd10 digital ; philips , the netherlands).21 
  all segments of the coronary arteries were characterized and recorded in the database following standard segmentation and lesion classification . all intraprocedural complications ( death , coronary perforation , stroke , hemorrhages , malignant arrhythmia , and mechanical ventilation ) were recorded . the threshold for ras was set at > 50% stenosis ( and defined as ras+ ) based on the american heart association guidelines for the reporting of renal artery revascularization in clinical trials.22 
  serum glucose , hemoglobin , leukocytes , platelets , total cholesterol , high density lipoprotein and low density lipoprotein fractions , uric acid , creactive protein , troponin i , creatine kinase  mb fraction , serum urea , and creatinine ( estimated glomerular filtration rate , [ egfr ] , by ckdepi formula ) were recorded at admission , before pci . for this analysis we used the body composition monitor ( bcm , fresenius medical care , germany ) portable device . with the patient in supine position , we placed electrodes on 1 hand and 1 foot . results were recorded in 2  minutes on a dedicated card , and transferred through fluid management tool software ( fresenius medical care singapore pte ltd , singapore ) . extracellular water ( ecw ) , intracellular water ( icw ) , total body water ( tbw ) , lean body mass , and fat tissue mass were recorded in the 24  hours following pci . bioimpedance spectroscopy23 evaluates total , extra and intracellular fluid status and fat / nonfat tissue mass , with excellent intra and interobserver reproducibility.24 bioimpedancederived parameters had a prognostic significance25 not only in hemodialysis , but also in early stages of ckd,26 including correlations between fluid imbalance and severity of cad.27 
  the sphygmocor ( atcor , australia ) device was used to acquire carotidfemoral ( cfpwv ) and carotidradial pwv wave velocities and aortic augmentation index in the 24  hours following pci . methods , techniques , and acquisition software have been described previously.28 cfpwv is the  gold standard  for arterial stiffness and brings the greatest epidemiological evidence for its predictive value for mace.29 
  continuous variables are expressed as meansd and nominal data as number with percent frequency . normality of the distribution of the variables was tested with the shapiro  wilk test . betweengroup comparisons were performed for nominal data with the  test , and by independent t test or mann  whitney test for the rest of variables , as appropriate . stepwise multivariate logistic regression analysis including all univariate associates of ras+ ( p<0.05 ) was used to evaluate different predictive models for ras+ . due to multicollinearity , variables derived from the bcm measurements ( tbw , ecw , icw ) that were associated with ras+ in the univariate regression analysis were introduced separately in the multivariate logistic regression analysis . we determined the bayesian information criterion and the akaike information criterion for each final model ; there is no statistical test that compares different bayesian or akaike information criterion estimations , and a lower value indicates a better fitted model . all statistical analyses were performed with spss 19.0 ( spss inc , chicago , il ) . between october 2014 and march 2015 , all consecutive patients with ami included in romanian national program of primary percutaneous revascularization were enrolled in our prospective , nonrandomized singlecenter study ( renacs ) . the  gr .  t. popa  iasi university ethics committee approved the protocol . all patients were admitted for emergency percutaneous coronary intervention ( pci ) and treated following european standard protocols.19 in the same procedure we performed diagnostic ra . on the basis of clinical examination and interview defined previously20 ( adapted after the european cards registration data standards ) , we obtained data on the following : medical history ( relevant to cad and ras  previous pci , ckd , chronic heart failure , and pad ) , cardiovascular risk factors ( smoking , dyslipidemia , diabetes mellitus , hypertension ) , and killip class . cardiac echography was performed prior to angiography . in the first 24  hours postpci we assessed bioimpedancederived parameters and arterial stiffness . we performed coronary angiography via right femoral artery and treated coronary lesions ( thrombus aspiration , coronary stenting ) as usual.19 therapeutic decisions were not influenced by study requirements . after coronarography , ra was performed by selective injection of 10  ml contrast medium through a 6f diagnostic catheter in renal arteries . coronarographic lesions were assessed and reported during the procedure . after the pci procedure , all patients received standard intravenous and oral hydration fluids ( 500 to 1000  ml saline iv and 1000  ml water , respectively ) . ra images were analyzed offline in the first 24  hours by 2 independent operators , using angiographic software tools . using the catheter as a scaling device , percent diameter stenosis and renal diameters were computed ( philips allura xper fd10 digital ; philips , the netherlands).21 
  all segments of the coronary arteries were characterized and recorded in the database following standard segmentation and lesion classification . all intraprocedural complications ( death , coronary perforation , stroke , hemorrhages , malignant arrhythmia , and mechanical ventilation ) were recorded . the threshold for ras was set at > 50% stenosis ( and defined as ras+ ) based on the american heart association guidelines for the reporting of renal artery revascularization in clinical trials.22 serum glucose , hemoglobin , leukocytes , platelets , total cholesterol , high density lipoprotein and low density lipoprotein fractions , uric acid , creactive protein , troponin i , creatine kinase  mb fraction , serum urea , and creatinine ( estimated glomerular filtration rate , [ egfr ] , by ckdepi formula ) were recorded at admission , before pci . for this analysis we used the body composition monitor ( bcm , fresenius medical care , germany ) portable device . with the patient in supine position , we placed electrodes on 1 hand and 1 foot . results were recorded in 2  minutes on a dedicated card , and transferred through fluid management tool software ( fresenius medical care singapore pte ltd , singapore ) . extracellular water ( ecw ) , intracellular water ( icw ) , total body water ( tbw ) , lean body mass , and fat tissue mass were recorded in the 24  hours following pci . bioimpedance spectroscopy23 evaluates total , extra and intracellular fluid status and fat / nonfat tissue mass , with excellent intra and interobserver reproducibility.24 bioimpedancederived parameters had a prognostic significance25 not only in hemodialysis , but also in early stages of ckd,26 including correlations between fluid imbalance and severity of cad.27 the sphygmocor ( atcor , australia ) device was used to acquire carotidfemoral ( cfpwv ) and carotidradial pwv wave velocities and aortic augmentation index in the 24  hours following pci . methods , techniques , and acquisition software have been described previously.28 cfpwv is the  gold standard  for arterial stiffness and brings the greatest epidemiological evidence for its predictive value for mace.29 normality of the distribution of the variables was tested with the shapiro  wilk test . betweengroup comparisons were performed for nominal data with the  test , and by independent t test or mann  whitney test for the rest of variables , as appropriate . stepwise multivariate logistic regression analysis including all univariate associates of ras+ ( p<0.05 ) was used to evaluate different predictive models for ras+ . due to multicollinearity , variables derived from the bcm measurements ( tbw , ecw , icw ) that were associated with ras+ in the univariate regression analysis were introduced separately in the multivariate logistic regression analysis . we determined the bayesian information criterion and the akaike information criterion for each final model ; there is no statistical test that compares different bayesian or akaike information criterion estimations , and a lower value indicates a better fitted model . all statistical analyses were performed with spss 19.0 ( spss inc , chicago , il ) . one hundred eightyone of the 250 consecutive patients who underwent primary pci ( ppci ) fulfilled the inclusion criteria ( figure  1 ) , of which 81 ( 45% ) had renal atherosclerotic lesions ( both significant and not significant lesions ) , 59 ( 32.6% ) had unilateral ras , and 22 ( 12.2% ) had bilateral ras . ras+ ( as defined by > 50% stenosis ) was present in 16.6% of the population . there were 135 ( 64.5% ) men , 55 ( 30.4% ) of the patients had preexisting cad , 13 ( 7.2% ) had ckd , and 36 ( 20% ) had chronic heart failure . twenty percent of the population had left ventricular ejection fraction > 50% , and 18.2% had left ventricular ejection fraction < 30% . the mean cfpwv was 9.42.5  m / s . fluid status measurements showed mean values for relative fluid overload10.6215.13% ( table  1 ) . flowchart of patient recruitment . missing data : 3 patients without full demographics , 4 patients without complete medical history , 9 patients without laboratory data . ami indicates acute myocardial infarction ; bcm , body composition monitor ; cf and cr pwv , carotidfemoral and carotidradial pulsedwave velocity ; ppci , primary percutaneous coronary intervention ; ra , renal angiography . characteristics of the study population according to the occurrence of ras afo indicates absolute fluid overload ; aix , augmentation index ; bun , blood urea nitrogen ; cabg , coronary artery bypass graft ; cad , coronary artery disease ; cf and crpwv , carotidfemoral and carotidradial pulsedwave velocity ; chf , chronic heart failure ; ckd , chronic kidney disease ; ckmb , creatine kinase mb fraction ; ecw , extracellular water ; egfr , estimated glomerular filtration rate ; ftm , fat tissue mass ; hb , hemoglobin ; hdl , high density lipoprotein ; icw , intracellular water ; ldl , low density lipoprotein ; ltm , lean tissue mass ; lvef , left ventricular ejection fraction ; pad , peripheral artery disease ; pci , percutaneous coronary intervention ; ras , renal artery stenosis ; rfo , relative fluid overload ; tbw , total body water . we further stratified the study population according to the presence of ras+ ( table  1 ) . the presence of most cardiovascular risk factors ( smoking , ckd , dyslipidemia , hypertension ) , as well as pad and stroke were not different between the 2 groups . however , there were more women with ras+ and a higher prevalence of cad and chronic heart failure . these patients were older , suffering more from previous pci and from multivascular coronary artery disease . killip class and left ventricular ejection fraction were not significantly different between the 2 groups . fibrinogen and crusade score were higher , while egfr was significantly lower in the ras+ subgroup . the same subgroup had lower tbw , ecw , intracellular water , and lean tissue mass , but similar afo and relative fluid overload as compared to the ras patients . there was also no difference between the 2 groups in regard to blood urea nitrogen : creatinine ratio ( as another estimation of dehydration ) and in the use of diuretics . all independent determinants of ras+ , with odds ratios and 95% cis are shown in table  2 . cad indicates coronary artery disease ; cfpwv , carotidfemoral pulsedwave velocity ; ecw , extracellular water ; egfr , estimated glomerular filtration rate ; icw , intracellular water ; pci , percutaneous coronary intervention ; ras , renal artery stenosis ; tbw , total body water . in multivariate models , variables that remained independently associated with ras+ were previous pci , egfr , multivascular coronary artery disease , and tbw or ecw ( tables  3 and 4 ) . the model that included tbw had lower akaike information criterion ( 143.2 versus 143.7 ) and bayesian information criterion ( 148.6 versus 149.2 ) scores , but higher area under receiver operating characteristic ( auroc ) ( 0.786 , 95% ci 0.705 to 0.867 versus 0.774 , 95% ci 0.692 to 0.857 ) than the model with ecw ( figure  2 ) . both models had identical accuracy ( 84.5% ) , specificity ( 98.7% ) , sensitivity ( 13.3% ) , and positive ( 66.7% ) and negative ( 83.4% ) predictive values . multivariate associates of ras ( with tbw ) egfr indicates estimated glomerular filtration rate ; pci , percutaneous coronary intervention ; ras , renal artery stenosis ; tbw , total body water . multivariate associates of ras ( with ecw ) ecw indicates extracellular water ; egfr , estimated glomerular filtration rate ; pci , percutaneous coronary intervention ; ras , renal artery stenosis . performance of the models for predicting ras . the difference between the 2 aucs is 0.012 , not significant ( p=0.37 , delong method ) . auc indicates area under curve of roc ; ecw , extracellular water ; ras , renal artery stenosis ; roc , receiver operating characteristics ; tbw , total body water . one hundred eightyone of the 250 consecutive patients who underwent primary pci ( ppci ) fulfilled the inclusion criteria ( figure  1 ) , of which 81 ( 45% ) had renal atherosclerotic lesions ( both significant and not significant lesions ) , 59 ( 32.6% ) had unilateral ras , and 22 ( 12.2% ) had bilateral ras . ras+ ( as defined by > 50% stenosis ) was present in 16.6% of the population . there were 135 ( 64.5% ) men , 55 ( 30.4% ) of the patients had preexisting cad , 13 ( 7.2% ) had ckd , and 36 ( 20% ) had chronic heart failure . twenty percent of the population had left ventricular ejection fraction > 50% , and 18.2% had left ventricular ejection fraction < 30% . the mean cfpwv was 9.42.5  m / s . fluid status measurements showed mean values for relative fluid overload10.6215.13% ( table  1 ) . flowchart of patient recruitment . missing data : 3 patients without full demographics , 4 patients without complete medical history , 9 patients without laboratory data . ami indicates acute myocardial infarction ; bcm , body composition monitor ; cf and cr pwv , carotidfemoral and carotidradial pulsedwave velocity ; ppci , primary percutaneous coronary intervention ; ra , renal angiography . characteristics of the study population according to the occurrence of ras afo indicates absolute fluid overload ; aix , augmentation index ; bun , blood urea nitrogen ; cabg , coronary artery bypass graft ; cad , coronary artery disease ; cf and crpwv , carotidfemoral and carotidradial pulsedwave velocity ; chf , chronic heart failure ; ckd , chronic kidney disease ; ckmb , creatine kinase mb fraction ; ecw , extracellular water ; egfr , estimated glomerular filtration rate ; ftm , fat tissue mass ; hb , hemoglobin ; hdl , high density lipoprotein ; icw , intracellular water ; ldl , low density lipoprotein ; ltm , lean tissue mass ; lvef , left ventricular ejection fraction ; pad , peripheral artery disease ; pci , percutaneous coronary intervention ; ras , renal artery stenosis ; rfo , relative fluid overload ; tbw , total body water . we further stratified the study population according to the presence of ras+ ( table  1 ) . the presence of most cardiovascular risk factors ( smoking , ckd , dyslipidemia , hypertension ) , as well as pad and stroke were not different between the 2 groups . however , there were more women with ras+ and a higher prevalence of cad and chronic heart failure . these patients were older , suffering more from previous pci and from multivascular coronary artery disease . killip class and left ventricular ejection fraction were not significantly different between the 2 groups . fibrinogen and crusade score were higher , while egfr was significantly lower in the ras+ subgroup . the same subgroup had lower tbw , ecw , intracellular water , and lean tissue mass , but similar afo and relative fluid overload as compared to the ras patients . there was also no difference between the 2 groups in regard to blood urea nitrogen : creatinine ratio ( as another estimation of dehydration ) and in the use of diuretics . all independent determinants of ras+ , with odds ratios and 95% cis are shown in table  2 . univariate associates of ras cad indicates coronary artery disease ; cfpwv , carotidfemoral pulsedwave velocity ; ecw , extracellular water ; egfr , estimated glomerular filtration rate ; icw , intracellular water ; pci , percutaneous coronary intervention ; ras , renal artery stenosis ; tbw , total body water . in multivariate models , variables that remained independently associated with ras+ were previous pci , egfr , multivascular coronary artery disease , and tbw or ecw ( tables  3 and 4 ) . the model that included tbw had lower akaike information criterion ( 143.2 versus 143.7 ) and bayesian information criterion ( 148.6 versus 149.2 ) scores , but higher area under receiver operating characteristic ( auroc ) ( 0.786 , 95% ci 0.705 to 0.867 versus 0.774 , 95% ci 0.692 to 0.857 ) than the model with ecw ( figure  2 ) . both models had identical accuracy ( 84.5% ) , specificity ( 98.7% ) , sensitivity ( 13.3% ) , and positive ( 66.7% ) and negative ( 83.4% ) predictive values . multivariate associates of ras ( with tbw ) egfr indicates estimated glomerular filtration rate ; pci , percutaneous coronary intervention ; ras , renal artery stenosis ; tbw , total body water . multivariate associates of ras ( with ecw ) ecw indicates extracellular water ; egfr , estimated glomerular filtration rate ; pci , percutaneous coronary intervention ; ras , renal artery stenosis . performance of the models for predicting ras . the difference between the 2 aucs is 0.012 , not significant ( p=0.37 , delong method ) . auc indicates area under curve of roc ; ecw , extracellular water ; ras , renal artery stenosis ; roc , receiver operating characteristics ; tbw , total body water . this crosssectional , reallife observational study evaluated clinical and paraclinical characteristics of ami patients with respect to angiographically diagnosed ras . we investigated ( 1 ) ras prevalence in this cohort , and ( 2 ) the relationship between ras , arterial stiffness , and hydration status . there are few trials5 that analyzed the incidence of ras in cad , whereas no study evaluated an ami cohort . we performed systematic ra in consecutive ami patients , regardless of other risk factors suggesting ras ( severe hypertension , pad , or abdominal bruits ) . data showed concordant values of ras prevalence in ami ( 16.6% ) to those reported in wellrecognized risk groups ( suspected renovascular hypertension5 , 3014.1% , hypertension and diabetes mellitus3117.1% , chronic cad5 , 32 , 339.1% to 10.8% ) but lower values than in patients with chronic heart failure3454.1% , aortic abdominal aneurysm3538% , endstage renal disease3640.8% . differences between reports are driven by inclusion of patients with different stages of atheromatous disease and inflammation . the relationship between extent of cad and ras has been previously evaluated in elective patients37 : the number of diseased coronary arteries roughly multiplies by 5 the prevalence of ras.5 in our study , the degree of cad was a strong predictor for ras in multivariate analysis , reflecting progressive stages of multisite disease . this is the first reported trial that assessed arterial stiffness ( pwv ) and hydration status ( bcm ) in ami patients . previous studies have observed a predictive role for cfpwv in primary14 and recurrent coronary events.38 our data suggests that arterial rigidity is associated with increased prevalence of ras in ami . stiffness and ras could be a result of extensive atheromatosis , or marker for an aggressive risk factor profile ( severe hypertension , ckd , inflammation ) . in both scenarios , elevated rigidity after ami would predict high risk of secondary mace.39 further research is needed to refine predictive power of the interaction between stiffness and ras+ phenotype . ami ras+ patients had significantly lower egfr , which is linked to more extensive and severe cad40 and correlated with higher mace after an ami.41 a decline in egfr could be due to ras ( chronic ischemic nephropathy ) and/or coexistence of multiple risk factors . moreover , crusade score was significantly higher in the ras+ subgroup , leading to future greater mace risk.42 
  we are the first suggesting the importance of bioimpedance with respect to ras coexistence in ami . previous studies ( in ami ) derived hydration status from blood and urine osmolality , not taking into account ras as modulator.17 , 43 , 44 , 45 using a more objective46 and reproducible47 measurement we revealed that ( 1 ) all patients with ami were relatively dehydrated , dehydration being possibly an unrecognized risk factor for ami17 , 44 ; ( 2 ) ras+ patients were significantly more dehydrated than the ras population . however , severe dehydration in ami could be a distinct and multiorigin risk factor that can not be compensated by the renin system hyperactivity . since bcm parameters are easily acquired at the patient 's bedside by nonspecialized medical personnel , this investigation could be performed routinely in ami and should be included in a screening protocol . more studies using bioimpedance are necessary to understand the role of hydration status in ami . previous data has raised the concern of elaborating a predictive model for ras , in chronic cad.6 , 48 considering that ra is a simple and harmless technique for ras diagnosis , we recommend it as screening ( at the same time as ppci ) , when dealing with particular subsets of ami patients ( previous pci , multivascular coronary artery disease , lower egfr , and dehydrated ) . the advantages of a screening protocol could be the following : better prediction of further mace risk,33 reducing cardiovascular risk , optimal adjustment of antiplatelet , anticoagulant , and angiotensinconverting enzyme inhibitors treatment,49 better control of hypertension,50 and limitation of progression to endstage renal disease.36 
  our study was done in a single center and referral bias could be a limiting factor . data were derived from 181 patients , but a larger group might have given us more precise information . although our study suggests a screening protocol , more data are required to improve characteristics of the ras+ami subgroup . ras significance cutoff was set at > 50% , but transstenotic gradient was not performed to determine ras hemodynamic relevance . if we had set the cutoff value at a different limit , relevance of variables included in analysis could have been different . our study was done in a single center and referral bias could be a limiting factor . data were derived from 181 patients , but a larger group might have given us more precise information . although our study suggests a screening protocol , more data are required to improve characteristics of the ras+ami subgroup . ras significance cutoff was set at > 50% , but transstenotic gradient was not performed to determine ras hemodynamic relevance . if we had set the cutoff value at a different limit , relevance of variables included in analysis could have been different . we recorded ra , pwv , and bioimpedancederived parameters in consecutive ami patients referred for ppci . ras+ ami patients have a particular hydration , metabolic , and endothelial profile that could generate further mace .
backgroundwe are the first to evaluate the prevalence of renal artery stenosis ( ras ) in consecutive patients with acute myocardial infarction ( ami ) referred for primary percutaneous coronary intervention from a single tertiary center . as a novelty , we assessed hydration and metabolic status and measured arterial stiffness . 
 we elaborated a predicting model for ras in ami.methods and resultsone hundred and eightyone patients with ami underwent concomitantly primary percutaneous coronary intervention and renal angiography . 
 we obtained data on demographics , medical history , cardiovascular risk factors , echocardiography , killip class , and blood tests . in the first 24  hours post  primary percutaneous coronary intervention , we assessed bioimpedance through body composition monitoring and arterial stiffness through pulsedwave velocity , sphygmocor. significant ras ( > 50% lumen narrowing , ras+ ) was present in 16.6% patients . in the ras+ group 
 we recorded significantly higher stiffness , crusade score and dehydration , and more women with higher prevalence of multivascular coronary artery disease and heart failure . in our multivariate models , variables independently associated with ras+ were previous percutaneous coronary intervention , low estimated glomerular filtration rate , multivascular coronary artery disease , and total / extracellular body water . 
 these models had good specificity and low sensitivity.conclusionswe observed that ras+ ami patients have a particular hydration , metabolic , and endothelial profile that could generate more future major adverse cardiac events . 
 hence , renal angiography in ami should be considered in specific subsets of patients.clinical trial registration 
 url : https://www.clinicaltrials.gov/. unique identifier : nct02388139 .