axillary brachial plexus block is a common regional anesthesia and peripheral nerve block technique in upper extremity surgery . it is very important to localize the nerve that shall be blocked and there are several ways to find the position of the nerves . generally , these methods are four major techniques named as sensation of paresthesia , anatomical landmarks , nerve stimulation and at last ultrasonography 1 - 6 . previously , ultrasound has been used to guide catheter placement and needle insertion in only radiology area , but now it is used commonly in nerve block for regional anesthesia by anesthesiologists . ultrasound helps identification of the target tissue , nerve , vessel and other structures so that needle placement can be made accurately and safely 4 , 5 . ultrasound guided regional anesthesia with conventional block needles may be difficult due to conventional needle tips are non - echogenic . owing to technological improvements of needle visualization new echogenic needles are started to be used in clinical practice 3 , 5 , 6 . despite some studies comparing echogenic and non - echogenic needles , according to our review of literature it could not be found any study which compares echogenic , non - echogenic needles and nerve stimulator assistance together in a clinical study on the basis of operation outcomes such as block quality , performing time , pain and satisfaction scores . in this study we aimed to compare outcomes of the echogenic needles and non - echogenic needles with nerve stimulation addition in ultrasound guided axillary brachial plexus block for upper extremity surgery . this randomized controlled clinical study was performed after the approval of the ethical committee ( number : 2011 - 04/15 ) and written informed consent of the patients . in this study , 90 asa physical status i - ii patients scheduled for upper extremity surgery under axillary nerve block were enrolled . patients with a history of coagulopathy , local anesthetic allergy , respiratory failure , cardiac disease , hepatic failure , or renal failure , receiving chronic analgesic therapy , obesity ( body mass index > 27 ) and pregnancy were exclusion criteria for the study . the patients were allocated into three groups randomly : group e ( n = 30 ) : ultrasound guided axillary block with echogenic needle , group n ( n = 30 ) : ultrasound guided axillary block with non - echogenic needle , group ns ( n = 30 ) : ultrasound guided axillary block with non - echogenic needle using nerve stimulator assistance . the randomization was achieved by a random number table and the patients were not informed about their groups . patients were not given any premedication before the operation . just before the block procedure mean arterial blood pressures ( map ) , heart rate ( hr ) , and peripheral oxygen saturation ( spo2 ) monitoring were performed and baseline values were recorded . axillary block was performed while the patient in the supine position , the elbow with 110 flexion and the upper arm with 90 abduction . all block procedure was performed using the same ultrasound ( ezono 3000 portable ultrasound , germany ) device with a 4 cm probe and frequency of 6 - 10 mhz ( ezono linear probe , germany ) . group e patients were blocked using an echogenic 22 g , 50 mm stimulating needle ( stimuplex ultra , b.braun melsungen ag ) with the guidance of only ultrasound device , group n patients were blocked using a non - echogenic 22 g , 50 mm stimulating needle ( stimuplex a , b.braun melsungen ag ) with the guidance of only ultrasound device , group ns patients were blocked using non - echogenic 22 g , 50 mm stimulating needle with the guidance of both ultrasound and nerve stimulator ( stimuplex , b.braun , melsungen ag ) . all patients were injected the same solution named as levobupivacaine ( chirocaine , 5 mg ml ; abbott lab / usa ) 15 ml plus isotonic nacl 0.9% 5 ml after identifying the nerves . in order to avoid intravascular injection negative aspiration the patients with inadequate block , or block failure in a nerve distribution region were excluded . one anesthesiologist that had equal experience in both ultrasound guided block and nerve stimulator technique performed all nerve blocks . hr , map , spo2 values were recorded before and after the block in 10 minute intervals . demographic data , duration of block procedure , sensory and motor block onset time , duration of sensory and motor block , were also recorded by assesing sensory block by pinprick test and motor blockade using a modified levvott rating scale from 6 ( normal muscular force ) to 0 ( complete paralysis ) . duration of block procedure was defined as the time from first skin puncture to the end of local anesthetic injection . sensory and motor block onset time was considered as the time between finishing injection of local anesthetic and to no response to the pinprick test and full paralysis . the duration of sensory block was accepted as the time between the sensory block completion and the first pain postoperatively . the duration of motor block was indicated as the time between the full paralysis and recovery of motor functions . pain levels at postoperative period were assessed using a 10 cm visual analog scale ( vas ) from 0 ( no pain ) to 10 ( severe pain ) . satisfaction scores of patients and surgeons were also recorded after the operation using a 5 point scale from 1 ( very bad ) to 5 ( excellent ) . hypotension , hypoxemia , bradycardia , nausea and vomiting were also recorded if occurred . in case of hypotension , hypoxemia and bradycardia , it was planned to perform ephedrine 10 mg iv , o2 4 - 5 l hr with face mask and atropine 1 mg iv respectively . if a vas value was above 5 , we performed a pilot study of 15 patients ( 5 in each group ) before our main study , and calculated that a sample size of 30 patients in each group would be sufficient at an assumed 20% difference in duration of block procedure . statistical power was calculated to be 0.82 as  = 0.05 ,  = 0.18 . the data of age , height , weight , surgery time , onset time , and duration of sensory and motor block was evaluated by the kolmogorov - smirnov test . age , height , weight , surgery time , onset time , and duration of sensory and motor block were compared between the groups by anova test and reported as mean  sd . the sex and asa physical status were compared with chi - square test . three patients from group n ( n=27 ) , one patient from group e ( n=29 ) and one from group ns ( n=29 ) were excluded from the study because of inadequate block . duration of block procedure values were found similar in group e and group ns and significantly lower than in group n ( p<0.05 ) . sensory and motor block onset time values were found higher in group e and group n , besides significantly higher in group n than in group e ( p<0.05 ) . sensory and motor block durations , were found higher in group e and group ns than in group n ( p<0.05 ) ( table 2 ) . postoperative vas value of 12 hr was similar in all groups ( table 2 ) . total need for analgesics and time to first analgesic use were similar in all groups . number of patients that needed additional analgesic in postoperative 12 hours was similar in all groups . patient and surgeon satisfaction scores were higher in group e and group ns ( p<0.05 ) ( table 3 ) . no side effects were seen in any patients . none of the patients had the hypotension , bradycardia or a hypoxemia episode which required treatment during neither intraoperative nor postoperative period . our study demonstrates that echogenic needles and nerve stimulator assisted non - echogenic needles have shorter block performing times , shorter sensory and motor block onset times and a longer sensory and motor block duration when compared to non - echogenic needles in ultrasound guided axillary brachial plexus block . peripheral nerve blocks have been performed with the help of nerve stimulators before the introduction of ultrasound guidance in regional anesthesia practice 1 . peripheral nerve stimulation technique has been called blind method because it does not visualize the nerves and needle 3 . inspite of this it has been performed successfully by using nerve stimulators 2 , 7 , 8 . ultrasound guidance in regional anesthesia made nerves visible and improved peripheral nerve block success and safety 5 , 9 . ultrasound assistance may be used with nerve stimulation to expedite onset of axillary brachial plexus block 9 . in a recent animal study of vassiliou et al . 10 it was concluded that dual use of ultrasound and nerve stimulation together provides a higher rate of close needle - to - nerve placement and a lower incidence of hematoma . this study was performed using non - echogenic needles with the assistance of both ultrasound and nerve stimulation . 11 indicated in their study that ultrasound assistance to nerve stimulation had no advantages if it was performed by experienced users , further is the nerve stimulation technique also an important technique for trainees ' first learning . in time , as the anesthetists gained experience and as the technology improved both the areas of ultrasound and needle visibility , they began to use ultrasound solely for nerve blocks . there are some studies comparing nerve stimulation and ultrasound technique in peripheral nerve blocks and different results were found . in the study of casati et al . 12 , similar success rates for both techniques were indicated in axillary block . in a study by chan et al . 13 , it was concluded that ultrasound guidance significantly improves the success rate of axillary blocks . 14 concluded that ultrasound guidance for interscalene block does not offer major advantages over nerve stimulator guidance . 15 compared ultrasound and nerve stimulation techniques and found in their recent study that success rate and onset times of block were similar , although ultrasound guidance provided shorter procedural times , fewer needle and vascular punctures . in a study at 2012 , maalouf et al . 16 compared nerve stimulator versus ultrasound guidance for placement of popliteal catheters and found similar pain scores , procedure times and analgesic consumption but less local anesthetic doses with ultrasound guidance . in our study , we used ultrasound in all groups and compared different needles and nerve stimulator addition to non - echogenic needle . we conclude that ultrasound guidance improved the results in our study . besides , we indicate that nerve stimulation may improve the block quality of ultrasound guided axillary block when using non - echogenic needles . 17 indicated that the anesthetist 's skill in using and placing the ultrasound probe and needle is probably the most important variable influencing needle visibility . in our study all blocks were performed by the same experienced anesthetist , in order to gain most reliable results . needle visualization has been improving with the echogenic needles . in a review article of hocking et al . 18 it was concluded that a good echogenic needle should increase efficacy , safety and simplicity . in a recent study , guo et al . 19 compared different echogenic needles with non - echogenic needles in cadaver model and found echogenic needles more visible than non - echogenic needles . 20 also compared three different echogenic needles with non - echogenic needles and found no significant differences in overall visibility of the needle at different insertion angles . no significant differences were observed between the remaining echogenic designs and the non - echogenic control . in our study , we compared echogenic , non - echogenic needles and nerve stimulator assisted non - echogenic needles using sensory and motor block quality and additional pain scores . in conclusion , the outcomes of ultrasound guided axillary block with echogenic needles and nerve stimulation assisted ultrasound with non - echogenic needles are similar and better than solely non - echogenic needles . we assume that nerve stimulation assisted non - echogenic needles are as effective as echogenic needles in ultrasound guided axillary block .
objective : in this study we aimed to compare the echogenic needles and the nerve stimulation addition to non - echogenic needles in ultrasound guided axillary brachial plexus block for upper extremity surgery.methods : 90 patients were enrolled to the study . 
 the patients were allocated into three groups randomly : group e ( n=30 ) : ultrasound guided axillary block using echogenic needle , group n ( n=30 ) : ultrasound guided axillary block using non - echogenic needle , group ns ( n=30 ) : ultrasound guided axillary block using non - echogenic needle with nerve stimulator assistance . 
 duration of block procedure , mean arterial pressure , heart rate , pulse - oximetry , onset time of sensory and motor block , duration of sensory and motor block , time to first analgesic use , total need for analgesics , postoperative pain scores , patient and surgeon satisfaction scores were recorded.results : duration of block procedure values were lower in group e and ns , sensory and motor block durations , were significantly lower in group n. sensorial and motor block onset time values were found lower in group ns but higher in group n. patient and surgeon satisfaction scores were found lower in group n.conclusion : we conclude that ultrasound guided axillary block may be performed successfully using both echogenic needles and nerve stimulation assisted non - echogenic needles .