parkinson s disease ( pd ) is the second most common neurodegenerative disorder of the central nervous system , is difficult to cure , no treatment is sufficiently effective,1 and its incidence continues to increase with the aging global population . currently , it is estimated that in europe , there are over 1 million people diagnosed with pd , and globally about 5 million.2 considering the growing population of elderly people in europe , it is forecast that the number of patients with pd will double by 2030 , thus posing a serious challenge for the entire health care system.3,4 an extensive loss of dopaminergic neurons in the substantia nigra of the midbrain , which plays a crucial role in the etiopathogenesis of the disease , leads to drastic dopamine deficiency in the striatum . its deficiency is the cause of cardinal symptoms , such as resting tremor , bradykinesia , rigidity , muscle stiffness , postural instability , stooped posture of the body , and freezing gait . additional symptoms of the disease include hyposmia ( impaired sense of smell ) , gastrointestinal disorders , impaired mental function ( depression , anxiety , psychosis ) , sleep disorders , and dysphagia.5,6 studies and meta - analyses have concluded that the cause of pd in the vast majority of cases ( up to 90% ) is not known.1,7,8 in contrast , the underlying cause in 10% of cases has been confirmed to originate in genetic disorders , family history , toxic effects of exogenous and endogenous factors , exposure to pesticides , pollution , and improper lifestyle . studies have shown that pd undoubtedly leads to deterioration in quality of life in patients suffering from it , mainly due to the presence of a multitude of symptoms;6,9 therefore , currently it is a priority to carry out ongoing analyses of quality of life to monitor symptoms and applied treatment more efficiently , allocate financial resources properly to provide optimal patient care , and search for areas of deficit for improvement.1012 analysis of factors that additionally affect quality of life in patients with pd will allow more effective measures to be taken , aimed at improving functioning in daily life and general quality of life . the aim of this study was to assess the influence of selected variables on quality of life in people with idiopathic pd treated pharmacologically . the following hypotheses were formulated : 
 appearance of symptoms of depression have a negative impact on assessment of quality of life;acceptance of the disease positively correlates with subjective assessment of quality of life;self - reliant persons better assess quality of life . appearance of symptoms of depression have a negative impact on assessment of quality of life ; acceptance of the disease positively correlates with subjective assessment of quality of life ; self - reliant persons better assess quality of life . the study involved 50 patients diagnosed with pd and treated only pharmacologically , being members of an association supporting people with pd . inclusion criteria were confirmed diagnosis of pd based on medical records , age 4090 years , and no diagnosis of depression before the diagnosis of pd . exclusion criteria were secondary parkinsonism caused by organic disease or brain damage , no confirmed diagnosis of pd , and inability to fill out the survey form for mental reasons , eg , disorientation . the majority of patients were male ( 52% ) , aged 6170 years ( 48% ) , residents of cities with more than 100,000 inhabitants ( 42% ) , married ( 66% ) , with secondary education ( 52% ) , retired ( 60% ) , living together with the family ( 44% ) , and had been suffering from pd for 610 years ( 46% ) ( table 1 ) . all participants were informed of the study s purpose and course and the possibility of withdrawal from participation at every stage . the research project was approved by the bioethics committee of wrocaw medical university ( kb 534/2016 ) . all procedures performed in studies involving human participants were in accordance with the ethical standards of the committee and with the 1964 declaration of helsinki and its later amendments or comparable ethical standards . the diagnostic survey method was applied for the purposes of this study , with the use of the authors questionnaire and standardized questionnaires , ie , parkinson s disease questionnaire ( pdq)-39,13 beck depression inventory ( bdi),14 instrumental activities of daily living ( iadl ) scale,15 and acceptance of illness scale ( ais).16,17 the authors questionnaire was a survey with questions about sociodemographic data ( ie , age , sex , marital status , place of residence , education , professional activity , material status , managing household ) , duration of illness , type of medication administered due to pd , if a person had been treated for depression before the diagnosis of pd , and if a person had had any surgery to lessen the symptoms of pd . the pdq-9 is a versatile tool designed to assess the quality of life and health status of patients with pd . it consists of 39 parameters , arranged in eight scales of issues : mobility ( ten items ) , activities of daily living ( six items ) , emotional well - being ( six items ) , stigma ( four items ) , social support ( three items ) , cognition ( four items ) , communication ( three items ) , and bodily discomfort ( three items ) . patients answering questions about potential problems had to indicate the frequency with which they experienced problems by selecting a response ( scoring 04 ) on a scale of frequency : never ( 0 ) , occasionally ( 1 ) , sometimes ( 2 ) , often ( 3 ) , and always ( 4 ) . lower scores reflect a good level of functioning , while higher scores reflect difficulties in functioning.13,18,19 the bdi is a screening scale used in the initial diagnosis of depression . the test consists of 21 items relating to different symptoms of depression and is a self - report measure . there are four variants of answers indicating the intensity of symptoms : 0 , meaning no symptoms , up to 3 points , meaning very high intensity of a symptom . the minimum total score is 0 and the maximum 63 points . in practice , scores above 50 points are not obtained , due to the fact that people with severe depression are not able to take the test . the following guidelines are used in interpreting the total score : 010 , no depression or lower mood ; 1127 , moderate depression ; and 28 and above , severe depression . the iadl scale is used to assess the functional capacity of respondents in complex activities of daily living . the following parameters are taken into account : ability to use the phone , reaching remote locations farther than usual walking distance , ability to do shopping and prepare a meal , doing housework independently ( cleaning ) ,  do - it - yourself  activities ( repairing minor defects ) , taking medication as prescribed , and managing money . for each of the eight questions , a respondent has a choice of answer : without assistance ( 3 ) , with a little help ( 2 ) , and not able to do it ( 1 ) . the first response indicates the independence / autonomy of a patient in carrying out required tasks in everyday life , the second suggests inability to perform these tasks without the help of other people , and the third indicates dependence on others . the score is significant only in relation to a particular patient , and decline in score over time indicates a deterioration in general condition . the ais was adapted to polish conditions by juszczyski.17 the ais contains eight statements describing the consequences of the current state of health . in each response , a person evaluates their health on a 5-point scale , where 1 point means agree  , 3 points  do not know  , 4 points  do not agree  , and 5 points scores of 818 indicate a lack of acceptance of disease , 1929 an average level of acceptance , and 3040 acceptance of the health situation at a high level . the higher the score , the greater the acceptance of the disease , and thus better adaptation to the constraints imposed by the health situation and lower sense of psychological discomfort associated with the disease . low scores indicating a lack of acceptance and adaptation to the disease can be manifested through negative emotions . for all variables , the mean , median , extreme values , and standard deviation were calculated . in addition , this defined the dependence between selected variables using spearman s rank - correlation test . data were analyzed with statistica 12 ( statistica , tulsa , ok , usa ) . the study showed that the average assessment of functional capacity ( iadl ) in the study group was 17.944.04 ( 924 ) . it was shown that three - quarters of respondents could independently use the phone , take medications , and manage finances . unfortunately , only every third respondent could do housework or laundry independently . with a little help , in contrast , 10% of respondents were not able to reach places beyond a walking distance . the study results demonstrated statistically significant differences concerning independence in performing activities of daily living with regard to education , marital status , professional activity , managing household , and duration of disease . it was observed that people with primary education ( p=0.018 ) , married ( p=0.028 ) , living on a disability pension ( p=0.003 ) , assisted in daily activities ( p=0.008 ) , and with disease duration over 10 years ( p=0.034 ) had significantly lower autonomy in performing complex activities of daily living than other respondents . it was also shown that those who were more independent ( who received a higher score on the iadl scale ) were characterized by lower intensity of depressive symptoms ( received lower scores on the bdi ; =0.567 , p=0 ) and were more likely to accept their disease ( r=0.611 , p=0 ) ( figure 1 ) . analysis of data obtained through the ais showed that the average score for the study group was 25.287.26 . it was shown that 16% of respondents declared no disease acceptance , 22% a high level of disease acceptance , and 62% a moderate acceptance level . it was also shown that the level of acceptance of the disease correlated with occurrence of depressive symptoms ( =0.567 , p=0 ) . this means that those who were likely to accept the disease were characterized by lower intensity of depressive symptoms . the conducted studies showed that the average score of depression level in the study group was 13.589.289 ( 037 ) . analysis of the study material showed that 44% of people had no symptoms of depression , 48% were characterized by depression of moderate severity , and 8% had symptoms suggestive of severe depression . it was also shown that the occurrence of depressive symptoms in patients with pd was affected by marital status ( p=0.019 ) , professional activity ( p=0.005 ) , and disease duration ( p=0 ) . widowed people receiving disability pension and suffering for over 10 years were significantly more often diagnosed with depression of moderate severity than others . the results also showed the existence of a strong or very strong correlation between the independence level in performing complex activities of daily living and the domains of the questionnaire evaluating quality of life in patients with pd . this proved that people who were more self - reliant assessed quality of life better in each of the studied domains ( table 3 ) . correlations observed in four domains were moderate , and in two domains strong negative correlations between the results of the ais and the pdq-39 were observed . this means that people are more likely to accept the illness and the resulting difficulties and better assessed quality of life in the mobility domain ( =0.544 , p=0 ) , activities of daily living ( =0.464 , p=0.001 ) , family support ( =0.385 , p=0.006 ) , cognitive function ( =0.532 , p=0 ) , communication ( =0.483 , p=0 ) , and bodily discomfort ( =0.442 , p=0.001 ) . analysis of the study material also revealed the existence of the impact of depressive symptoms on quality of life in patients with pd . the occurrence of more severe depressive symptoms was associated with worse general quality of life and low quality of life in different domains ( figure 2 ) . the study showed that the average assessment of functional capacity ( iadl ) in the study group was 17.944.04 ( 924 ) . it was shown that three - quarters of respondents could independently use the phone , take medications , and manage finances . unfortunately , only every third respondent could do housework or laundry independently . with a little help , in contrast , 10% of respondents were not able to reach places beyond a walking distance . the study results demonstrated statistically significant differences concerning independence in performing activities of daily living with regard to education , marital status , professional activity , managing household , and duration of disease . it was observed that people with primary education ( p=0.018 ) , married ( p=0.028 ) , living on a disability pension ( p=0.003 ) , assisted in daily activities ( p=0.008 ) , and with disease duration over 10 years ( p=0.034 ) had significantly lower autonomy in performing complex activities of daily living than other respondents . it was also shown that those who were more independent ( who received a higher score on the iadl scale ) were characterized by lower intensity of depressive symptoms ( received lower scores on the bdi ; =0.567 , p=0 ) and were more likely to accept their disease ( r=0.611 , p=0 ) ( figure 1 ) . analysis of data obtained through the ais showed that the average score for the study group was 25.287.26 . it was shown that 16% of respondents declared no disease acceptance , 22% a high level of disease acceptance , and 62% a moderate acceptance level . it was also shown that the level of acceptance of the disease correlated with occurrence of depressive symptoms ( =0.567 , p=0 ) . this means that those who were likely to accept the disease were characterized by lower intensity of depressive symptoms . the conducted studies showed that the average score of depression level in the study group was 13.589.289 ( 037 ) . analysis of the study material showed that 44% of people had no symptoms of depression , 48% were characterized by depression of moderate severity , and 8% had symptoms suggestive of severe depression . it was also shown that the occurrence of depressive symptoms in patients with pd was affected by marital status ( p=0.019 ) , professional activity ( p=0.005 ) , and disease duration ( p=0 ) . widowed people receiving disability pension and suffering for over 10 years were significantly more often diagnosed with depression of moderate severity than others . the results also showed the existence of a strong or very strong correlation between the independence level in performing complex activities of daily living and the domains of the questionnaire evaluating quality of life in patients with pd . this proved that people who were more self - reliant assessed quality of life better in each of the studied domains ( table 3 ) . correlations observed in four domains were moderate , and in two domains strong negative correlations between the results of the ais and the pdq-39 were observed . this means that people are more likely to accept the illness and the resulting difficulties and better assessed quality of life in the mobility domain ( =0.544 , p=0 ) , activities of daily living ( =0.464 , p=0.001 ) , family support ( =0.385 , p=0.006 ) , cognitive function ( =0.532 , p=0 ) , communication ( =0.483 , p=0 ) , and bodily discomfort ( =0.442 , p=0.001 ) . analysis of the study material also revealed the existence of the impact of depressive symptoms on quality of life in patients with pd . the occurrence of more severe depressive symptoms was associated with worse general quality of life and low quality of life in different domains ( figure 2 ) . pd is characterized by a variety of symptoms that have a huge impact on the daily functioning of an affected person.20 therefore , one of the objectives in the treatment of pd should be to reduce the negative impact of symptoms on the daily functioning of patients , and thus also on their quality of life.21 however , sometimes a properly applied therapy fails to improve quality of life in patients , due to other factors , eg , mental condition , economic status , acceptance level of the disease , and related limitations . similar results were obtained by kurpas et al22 among patients with neurological diseases and kowalska et al23 among elderly patients hospitalized in a rehabilitation center for chronic diseases of old age , ie , osteoarthritis and pd . studies have also confirmed a statistically significant correlation between the functional status of elderly patients and stroke survivors and disease acceptance.23,24 kowalska et al24 also showed the existence of a stronger correlation between the severity of depressive symptoms and disease acceptance in stroke patients : more severe symptoms of depression were associated with poorer acceptance of the disease and its limitations , which was confirmed in this study . in the present study , similar results have also been obtained by other authors.25,26 however , in lorencowicz et al,27 the average score on the bdi for the study group was significantly lower . rana et al28 showed that single patients suffering from pd more often experience depression than patients with pd who are married , which was also confirmed in our study . seiler et al29 showed that a satisfying relationship with a partner may reduce the risk of depression in patients with pd . our data showed that people with more severe depression had lower assessment of quality of life . numerous studies carried out in different countries have confirmed the relationship between depression and deterioration in quality of life in patients with pd.2527,3039 our study results thus suggest that improvement in quality of life depends on early diagnosis and proper treatment of depression , which can result in reduction of certain somatic symptoms.25,26,35 one of the main symptoms of pd is a functional mobility disorder , which as the disease progresses affects functioning and performance of precise deliberate movements.40,41 people with pd have difficulty in daily functioning . the average score of functional capacity ( iadl ) was 17.944.04 ( 924 ) , confirming the results of lorencowicz et al.27 the existence of a strong relation between the degree of functionality and quality of life in patients with pd was also confirmed.26,27,37 people with worse functioning in daily life show low perception of quality of life . the study confirmed that the underlying cause of the symptoms of depression is the loss of functional capacity.27 lawrence et al35 suggested that the simultaneous occurrence of depression and reduced functional capacity affect deterioration in quality of life in patients with pd more than the occurrence of each variable separately . therefore , they recommended applying cognitive behavioral therapy in the treatment of people with pd , which will allow them to accept their limitations and the assistance of others , and thus reduce stress and tension . in the present study , we demonstrated that patients with pd provide the worst assessment in the domain of communications and mobility , and the average score obtained by respondents on the pdq-39 was 51.36 . similar results were also obtained by lorencowicz et al27 in poland , tams et al42 in hungary , klepac et al43 in croatia , and ziropaa et al44 in serbia . however , studies conducted in the us45 and australia35,46 revealed that the quality of life of their inhabitants with pd was definitely better , taking into account similar average age of patients and duration of disease . these differences may be associated with higher financial expenditure on health care in the us and australia , as well as providing proper care for the chronically ill . a sample size of one association was too small for conclusions and generalizations to be representative of all patients . however , this may be a starting point for further research seeking variables significantly affecting quality of life in patients with pd . factors such as depression , disease acceptance , and degree of functional capacity have a significant impact on subjective assessment of quality of life in patients with pd . the evaluation of these factors should be taken into account in the therapeutic process , to minimize their negative impact on quality of life in patients with pd .
backgroundparkinson s disease ( pd ) is the second most common neurodegenerative disorder after alzheimer s disease , and its incidence will increase as the global population ages . due to the multitude of symptoms , 
 this disease clearly has a significant impact on decreasing quality of life for those with pd . 
 we aimed to evaluate the effect of selected variables on quality of life in people with idiopathic pd treated pharmacologically.materials and methodsthis study was conducted among 50 patients with pd aged 4785 years . 
 the diagnostic survey method was applied to collect data with the use of the authors questionnaire and standardized questionnaires , including , parkinson s disease questionnaire ( pdq ) , beck depression inventory , instrumental activities of daily living scale , and acceptance of illness scale . 
 the results were statistically analyzed.resultsanalysis of the study material showed that people who were more self - reliant were characterized by lower intensity of depressive symptoms ( =0.567 , p=0 ) , were more likely to accept their illness ( =0.611 , p=0 ) , and assessed quality of life better in each of the studied domains of the pdq . 
 illness acceptance correlated with the occurrence of depressive symptoms ( =0.567 , p=0 ) and significantly affected quality of life.conclusionfactors such as depression , disease acceptance , and functional capacity have a significant impact on the subjective assessment of quality of life in patients with pd . 
 evaluation of these factors should be taken into account in the therapeutic process , to minimize their negative impact on quality of life in patients with pd .