smoking , alcohol , and substance use is a major health challenge in turkey and worldwide.13 studies in which the frequency of substance use was assessed have been conducted on a number of population groups in several turkish cities.1,4,5 although substance use and addiction are observed less commonly in females than in males in global studies , it is of concern that substance use has been identified as prevalent in females of childbearing age ( 1544 years).6,7 the prevalence of smoking , drinking , and substance use is known to vary , based on factors such as ethnicity , culture , and religious beliefs.8,9 in particular , while substance use in females in turkey is lower than that reported at global level , it is comparatively higher in young females of childbearing age.1 according to the 2013 national survey on drug use and health ( usa ) , 11.4% of nonpregnant females and 5.4% of pregnant females use illicit drugs , drink alcohol ( 55.4% and 9.4% , respectively ) , and smoke cigarettes ( 24% and 15.4% , respectively).8 the most frequently used legal substances in pregnancy were found to be cigarettes ( 10%23% ) and alcohol ( 10%12% ) in canada and the usa , while marijuana ( 5% ) and cocaine were determined to be the most prevalent illegal substances.10,11 polysubstance use was reported to be as high as 50% in some studies.12,13 while cigarette use in pregnancy has been investigated to some extent by clinicians , alcohol and substance use has generally escaped attention . based on turkish statistical institute ( tsi ) health research data from 2012 , 10.8% of females aged 15 years smoked every day , 12.7% had smoked at least once by this age , 3.8% drank alcohol regularly , and 92% had never consumed alcohol in their lives . the rates of drinking and smoking in females were found to be higher in urban areas.14 the prevalence of smoking during pregnancy was found to vary from 3% to 37% in turkish studies.15 nationwide studies on smoking , alcohol , and the use of other substances have not been carried out in turkey.15 it has been demonstrated in studies on pregnant females that while the frequency of substance use decreases at other times , it is still a significant health burden . smoking during pregnancy is associated with poor birth outcomes , such as low birthweight , intrauterine growth restriction , placental abruption , and placenta previa.16 alcohol ingested during pregnancy can have a deleterious impact on the developing fetus and includes fetal alcohol syndrome and alcohol - related effects.17 illicit drug use in pregnancy impacts negatively on the fetus and is associated with higher rates of prematurity , intrauterine growth restriction , placental abruption , neonatal withdrawal syndrome,18 and cognitive impairment.19 substance use in pregnancy has escaped the attention of most psychiatrists and gynecologists , despite having such a harmful effect . it is expected that most pregnant females who use harmful substances are motivated to quit when pregnant because they have a fetus . however , data on this subject are limited , but it has been reported in previous studies that it is not easy to readily quit smoking and other substances.20,21 the purpose of the present study was to investigate the frequency of smoking , alcohol , and substance use and quitting rates during pregnancy . this study was conducted on pregnant females , aged 1845 years , presenting at the outpatient clinic of obstetrics and gynaecology , sakarya university training and research hospital , turkey , and who agreed to participate therein . consecutively , presenting pregnant females ( 840 weeks ) admitted to our outpatient clinic for the first time between june and september 2015 ( 1,400 females ) were asked to participate in the study . study participants ( 1,082 ) with adequate intellectual - cognitive capacity to form a clinical impression and who were capable of understanding and completing a set of questions pertaining to the scale were included in the study . the addiction profile index,22 containing questions on sociodemographic data and the use and frequency of substance use , was adapted to incorporate information on substance use during pregnancy . the original form contained questions on the frequency of substance use over the last few preceding years . the adapted form contained questions on alcohol and substance use during the last and previous pregnancies . the form included five likert categories according to the period investigated , as follows : 
 never.at least once or twice.monthly ( one to three times / month).weekly ( at least once / week).daily ( at least once / day ) . at least once or twice . questions on a decoy substance , relactin , were also included and responses thereto were used to determine and predict the reliability of participants answers.5 the original addiction profile index form is a self - reporting scale consisting of 37 questions and five subscales covering substance use characteristics , addiction diagnosis criteria , the effect of substance use on a person s life , craving for a substance , and motivation to quit . in an analysis of the form s reliability , the cronbach s alpha coefficient for the entire scale was found to be 0.89 , while the subscale coefficients were determined to be between 0.63 and 0.86 . the scores for the substance correlation coefficients were between 0.42 and 0.89 for the entire scale . brown prediction formula was used to determine the split - half correlation , which was found to be 0.83 . the data were analyzed using statistical package for the social sciences ( spss ) version 17.0 ( spss inc . , chicago , il , usa ) . likert - type answers to the scale had to be selected , ranging from 0 to 4 . the normally distributed values were evaluated using a histogram and a test to measure skewness and kurtosis . variables that were not normally distributed were analyzed using the wilcoxon signed - rank sum test . all procedures performed in studies involving human participants were conducted in accordance with the ethical standards of the institutional and/or national research committee and the 1964 world medical association helsinki declaration and its later amendments . approval to conduct the study was obtained from the ethics committee of the faculty of medicine of sakarya university , turkey . written informed consent was obtained from all the participants who took part in the study . the addiction profile index,22 containing questions on sociodemographic data and the use and frequency of substance use , was adapted to incorporate information on substance use during pregnancy . the original form contained questions on the frequency of substance use over the last few preceding years . the adapted form contained questions on alcohol and substance use during the last and previous pregnancies . the form included five likert categories according to the period investigated , as follows : 
 never.at least once or twice.monthly ( one to three times / month).weekly ( at least once / week).daily ( at least once / day ) . at least once or twice . questions on a decoy substance , relactin , were also included and responses thereto were used to determine and predict the reliability of participants answers.5 the original addiction profile index form is a self - reporting scale consisting of 37 questions and five subscales covering substance use characteristics , addiction diagnosis criteria , the effect of substance use on a person s life , craving for a substance , and motivation to quit . in an analysis of the form s reliability , the cronbach s alpha coefficient for the entire scale was found to be 0.89 , while the subscale coefficients were determined to be between 0.63 and 0.86 . the scores for the substance correlation coefficients were between 0.42 and 0.89 for the entire scale . brown prediction formula was used to determine the split - half correlation , which was found to be 0.83 . the data were analyzed using statistical package for the social sciences ( spss ) version 17.0 ( spss inc . , likert - type answers to the scale had to be selected , ranging from 0 to 4 . the normally distributed values were evaluated using a histogram and a test to measure skewness and kurtosis . variables that were not normally distributed were analyzed using the wilcoxon signed - rank sum test . all procedures performed in studies involving human participants were conducted in accordance with the ethical standards of the institutional and/or national research committee and the 1964 world medical association helsinki declaration and its later amendments . approval to conduct the study was obtained from the ethics committee of the faculty of medicine of sakarya university , turkey . written informed consent was obtained from all the participants who took part in the study . this study was conducted on 1,082 pregnant females being monitored at the outpatient clinic ( obstetrics and gynecology ) at the hospital . the age of females ranged from 18 to 45 years , with an average age of 28.355.52 years . a quarter of the females ( n=253 , 23.4% ) were elementary school graduates and literate , 223 ( 20.6% ) were middle school graduates , 338 ( 31.2% ) were high school ( and equivalent ) graduates , and 268 were ( 24.8% ) university graduates . the median number of pregnancies was 2 ( with a range of 18 ) and the median number of children was 1 ( with a range of 06 ) . the study respondents admitted using alcohol , tobacco , and synthetic cannabinoids during their current and previous pregnancies and on a lifelong basis , but denied using marijuana ,  ecstasy  , heroin , cocaine ,  crack  , benzodiazepine , volatile substances , and amphetamine derivatives . none of the females reported using relactin . the ability of tobacco smokers to quit was evaluated after dividing them into two groups of daily smokers and those who smoked less frequently . nearly half of the daily smokers ( 42.5% ) did not quit smoking during their current pregnancy . the corresponding rate in the second group was 7.9% ( figures 1 and 2 ) . a comparison was made between the use of alcohol and substances during pregnancy and that over a lifetime . the use of tobacco was found to be significantly lower in previous pregnancies ( z=11,865 , p0.001 ) and in the current pregnancy ( z=14,820 , p0.001 ) than that over a lifetime ( wilcoxon signed - rank sum test ) . the same was found with respect to alcohol use in previous pregnancies ( z=3,901 ; p0.001 ) and in the current pregnancy ( z=5,103 , p0.001 ) ( wilcoxon signed - rank sum test ) . half of the participants who consumed alcohol daily continued to do so during their pregnancy . more than half of the respondents ( n=2 , 66.6% ) who reported using synthetic cannabinoids before their pregnancy continued to do so during the course of the pregnancy . linear regression analysis was performed to determine the factors that were predictive of the use of tobacco in the current pregnancy . this analysis involved the education level of the patients , whether or not alcohol and tobacco use had occurred throughout their lifetime , and the use of these substances in previous pregnancies . the results showed that while lifelong tobacco use and its use in previous pregnancies was a positive predictor of the use of tobacco in the current pregnancy , a significant correlation between education level and the use of alcohol was not observed ( table 2 ) . the same analysis was applied to gauge the factors that were predictive of the use of alcohol in the current pregnancy , using the same components as those included for tobacco ( education level of the patients , whether or not the alcohol and tobacco use had occurred throughout their lifetime , and the use of these substances in previous pregnancies ) . again , while the use of alcohol and cigarettes in previous pregnancies was found to be a positive predictor of the use of alcohol in the current pregnancy , a significant relationship between education level , the lifelong use of cigarettes , and the use of alcohol in the current pregnancy was not observed ( table 2 ) . the ability of tobacco smokers to quit was evaluated after dividing them into two groups of daily smokers and those who smoked less frequently . nearly half of the daily smokers ( 42.5% ) did not quit smoking during their current pregnancy . the corresponding rate in the second group was 7.9% ( figures 1 and 2 ) . a comparison was made between the use of alcohol and substances during pregnancy and that over a lifetime . the use of tobacco was found to be significantly lower in previous pregnancies ( z=11,865 , p0.001 ) and in the current pregnancy ( z=14,820 , p0.001 ) than that over a lifetime ( wilcoxon signed - rank sum test ) . the same was found with respect to alcohol use in previous pregnancies ( z=3,901 ; p0.001 ) and in the current pregnancy ( z=5,103 , p0.001 ) ( wilcoxon signed - rank sum test ) . half of the participants who consumed alcohol daily continued to do so during their pregnancy . more than half of the respondents ( n=2 , 66.6% ) who reported using synthetic cannabinoids before their pregnancy continued to do so during the course of the pregnancy . linear regression analysis was performed to determine the factors that were predictive of the use of tobacco in the current pregnancy . this analysis involved the education level of the patients , whether or not alcohol and tobacco use had occurred throughout their lifetime , and the use of these substances in previous pregnancies . the results showed that while lifelong tobacco use and its use in previous pregnancies was a positive predictor of the use of tobacco in the current pregnancy , a significant correlation between education level and the use of alcohol was not observed ( table 2 ) . the same analysis was applied to gauge the factors that were predictive of the use of alcohol in the current pregnancy , using the same components as those included for tobacco ( education level of the patients , whether or not the alcohol and tobacco use had occurred throughout their lifetime , and the use of these substances in previous pregnancies ) . again , while the use of alcohol and cigarettes in previous pregnancies was found to be a positive predictor of the use of alcohol in the current pregnancy , a significant relationship between education level , the lifelong use of cigarettes , and the use of alcohol in the current pregnancy was not observed ( table 2 ) . rates of alcohol and substance use are known to be lower in females than in males.1,2 only a limited number of studies have been published on the frequency of substance use during pregnancy in turkey.15,23,24 in the current study , the substances used by pregnant females were investigated using a self - report scale , according to which the use of tobacco , alcohol , synthetic cannabinoids , and various other drugs was assessed . thirty - four percent of the participants in this study reported that they had smoked cigarettes or other tobacco products at least once in their lifetime and 23% reported smoking every day prior to their pregnancy . based on tsi health research data from 2012 , in which the findings of various studies conducted in a number of cities at different times were amalgamated , 10.8% of turkish females smoked every day and 12.7% had smoked at least once.14 the smoking rate in this study was found to be higher than the national average . however , both lower and higher rates , by comparison , have been reported in regional studies on females.25,26 in this study , 11.1% of the females who had had multiparas reported that they had smoked cigarettes or other tobacco products at least once , 7.5% stated that they had smoked every day during their previous pregnancies , 11.8% of the currently pregnant participants said that they had smoked at least once , and 6.4% admitted to doing so every day . this shows that there was a significant decrease in the incidence of smoking during pregnancy for both daily and other smokers . however , 42.5% of the females who smoked daily and 7.9% of the other smokers continued to do so throughout their pregnancy . these data show that a significant number of females who smoke daily are not able to quit smoking easily , even when pregnant . the findings of a study conducted on 205 pregnant females in sakarya province , turkey , in 2006 were similar to those of this study ; 20% of the females smoked at least once a day when not pregnant and 62.5% of smokers did not quit during their pregnancy . similarly , it was shown in this study that the incidence of smoking was reduced during pregnancy , but that a significant number of pregnant females continued to smoke . the smoking rate was reported to be 17% at any time during pregnancy in another study from turkey , while the proportion of females who smoked during their entire pregnancy was 9%.26 the rates of smoking by pregnant females differ between countries . it was reported in a nationwide japanese study that 9.9% of pregnant females smoked and 38.1% continued to do so during pregnancy.27 elsewhere , it was reported in a study in australia that 17% of pregnant females smoked during pregnancy and that only 4% quit when pregnant.28 it was reported in a study conducted in greece that 48% of females use tobacco in the first trimester of pregnancy . of the tobacco users , 83.3% reported attempting to quit , but less than half ( 45.1% ) were successful.20 it was also shown in a study from russia that 25.2% of mothers were smokers before their pregnancy and that 18.9% continued to smoke while pregnant.29 the results of this study are congruent with those of previous studies.20,2729 thus , the need to screen for substance use and smoking during pregnancy is emphasized . it is harder for females who smoked on a daily basis prior to their pregnancy to quit smoking once pregnant . the rate of lifelong alcohol use in this study was found to be 3.9% , and 0.6% and 0.4% for previous pregnancies and the current pregnancy , respectively . there was a clear reduction in alcohol use during pregnancy , but remarkably , females who still drank alcohol during their pregnancy did so every day . based on countrywide data collected by the tsi in 2012 , 3.8% of females drank alcohol regularly , and 92% had never consumed alcohol.14 the alcoholic drinking rate for females was found to be higher than that for general society in research conducted on turkish youth , with a reduction in intersex difference . particular attention should be paid to alcohol consumption in a young woman s life as it negatively impacts on her reproductive cycle and pregnancy . to the best of the authors knowledge , the frequency of alcohol use during pregnancy has not been investigated in any study in turkey prior to this study . the consumption of alcohol during pregnancy has been assessed in retrospective studies.30,31 significantly , higher rates of alcohol consumption were reported in studies in which drinking prior to the discovery of the pregnancy was investigated , presumably because females who report alcohol use after the fact and outside of prenatal clinics are more truthful , and their information more reliable.30,31 rates of alcohol consumption in other countries vary , with a higher prevalence being reported in many european countries and australia . for example , it was found in a french study that only 53% of females reported complete abstinence from the consumption of alcohol during pregnancy.32 alcohol was consumed by 22.7% of pregnant females in a spanish study,33 24.6% of the females admitted to an antenatal clinic in australia self - reported alcohol consumption during pregnancy,34 and 40% of females reported at least one episode of binge drinking since conception in a study in denmark.34 rates in other countries also vary considerably , with 57.4% of females in a prenatal clinic in chile reporting alcohol consumption during pregnancy35 and rates of 46.7% and 59% being reported in relation to prenatal alcohol consumption in two russian studies.36,37 it seems that alcohol consumption during pregnancy is generally lower in turkey than it is elsewhere . the authors speculated that cultural factors , especially religion , may play an important role in this regard . however , the high number of identified females who drink alcohol daily and who continue to do so during their pregnancy ( 50% [ table 1 ] ) suggests that a comprehensive investigation into substance addiction in females should be carried out during all routine polyclinic procedures . while only five females in this study reported using synthetic cannabinoids , two admitted to using these substances in their previous and current pregnancies . the turkish national police department of police anti - smuggling and organized crime reported that the rate of illicit drug use on at least one occasion was 2.7% . the prevalence of drug use was higher in young adults ( aged 1534 years ) than that in the general population ( aged 1564 years ) . most ( 95.2% ) deaths directly relating to drugs were male victims , with only 4.8% of these being females . these data show that drug use is more common in males.1 although fewer females use illicit drugs , to do so during pregnancy increases the health risks in both the mother and infant . in this study , synthetic cannabinoid users tended to maintain the use of synthetic cannabinoids during pregnancy and thus were identified as a group in particular need of guidance and counseling . in this study , only one female reported using biperiden , alprazolam , and similar drugs outside her pregnancy . other drugs were not used during pregnancy in this study , but in a study that was conducted in sivas , turkey , the rate of volatile substance use ( lifelong at least once ) was found to be 16.3% in females and 9.3% in males , and that for cannabis was 1.6% in females and 2.1% in males.38 the use of inhalants in another study was determined to be 9% in males and 1% in females , and 8% in males and 7% in females for other drugs.26 substance use was assessed in 1,082 pregnant females in sakarya province in this study , and none of the study participants reported the use of illicit substances , with the exception of synthetic cannabinoids , during their pregnancy . although the results reflect low illicit substance and drug use , this study was of a limited size and was conducted on a specific sample . thus , the results pertaining to illicit substance and drug use can not be generalized to other pregnant females in sakarya province . smoking during previous pregnancies and over a lifetime was established to be prognostic of smoking during the most current pregnancy . this result is similar to those reported in previous studies.21,39 the fact that lifelong alcohol use and its use during a previous pregnancy is predictive of tobacco use in a current pregnancy can be explained by the co - occurrence of tobacco use in alcohol users . both the lifelong use of alcohol and its use in previous pregnancies were determined to be prognostic of the use of alcohol in the current pregnancy . this result is also not surprising.40 nevertheless , it emphasizes the idea that alcohol and substance use in prepregnancy should be investigated and should act as a  red flag  to their potential use in a future pregnancy . smoking during pregnancy and lifelong smoking have been identified in numerous studies as being prognostic of alcohol use in the current pregnancy.4043 factors such as age , education level , number of pregnancies , and marital status were not determined to be prognosticators of alcohol or smoking use in this study . these variables have been reported as being predictors of substance use in some studies , but same results were not replicated / obtained in whole of the studies.21,40 further studies will help to determine certain risk factors for smoking , alcohol and substance abuse during pregnancy . thirty - four percent of the participants in this study reported that they had smoked cigarettes or other tobacco products at least once in their lifetime and 23% reported smoking every day prior to their pregnancy . based on tsi health research data from 2012 , in which the findings of various studies conducted in a number of cities at different times were amalgamated , 10.8% of turkish females smoked every day and 12.7% had smoked at least once.14 the smoking rate in this study was found to be higher than the national average . however , both lower and higher rates , by comparison , have been reported in regional studies on females.25,26 in this study , 11.1% of the females who had had multiparas reported that they had smoked cigarettes or other tobacco products at least once , 7.5% stated that they had smoked every day during their previous pregnancies , 11.8% of the currently pregnant participants said that they had smoked at least once , and 6.4% admitted to doing so every day . this shows that there was a significant decrease in the incidence of smoking during pregnancy for both daily and other smokers . however , 42.5% of the females who smoked daily and 7.9% of the other smokers continued to do so throughout their pregnancy . these data show that a significant number of females who smoke daily are not able to quit smoking easily , even when pregnant . the findings of a study conducted on 205 pregnant females in sakarya province , turkey , in 2006 were similar to those of this study ; 20% of the females smoked at least once a day when not pregnant and 62.5% of smokers did not quit during their pregnancy . similarly , it was shown in this study that the incidence of smoking was reduced during pregnancy , but that a significant number of pregnant females continued to smoke . the smoking rate was reported to be 17% at any time during pregnancy in another study from turkey , while the proportion of females who smoked during their entire pregnancy was 9%.26 the rates of smoking by pregnant females differ between countries . it was reported in a nationwide japanese study that 9.9% of pregnant females smoked and 38.1% continued to do so during pregnancy.27 elsewhere , it was reported in a study in australia that 17% of pregnant females smoked during pregnancy and that only 4% quit when pregnant.28 it was reported in a study conducted in greece that 48% of females use tobacco in the first trimester of pregnancy . of the tobacco users , 83.3% reported attempting to quit , but less than half ( 45.1% ) were successful.20 it was also shown in a study from russia that 25.2% of mothers were smokers before their pregnancy and that 18.9% continued to smoke while pregnant.29 the results of this study are congruent with those of previous studies.20,2729 thus , the need to screen for substance use and smoking during pregnancy is emphasized . it is harder for females who smoked on a daily basis prior to their pregnancy to quit smoking once pregnant . the rate of lifelong alcohol use in this study was found to be 3.9% , and 0.6% and 0.4% for previous pregnancies and the current pregnancy , respectively . there was a clear reduction in alcohol use during pregnancy , but remarkably , females who still drank alcohol during their pregnancy did so every day . based on countrywide data collected by the tsi in 2012 , 3.8% of females drank alcohol regularly , and 92% had never consumed alcohol.14 the alcoholic drinking rate for females was found to be higher than that for general society in research conducted on turkish youth , with a reduction in intersex difference . particular attention should be paid to alcohol consumption in a young woman s life as it negatively impacts on her reproductive cycle and pregnancy . to the best of the authors knowledge , the frequency of alcohol use during pregnancy has not been investigated in any study in turkey prior to this study . the consumption of alcohol during pregnancy has been assessed in retrospective studies.30,31 significantly , higher rates of alcohol consumption were reported in studies in which drinking prior to the discovery of the pregnancy was investigated , presumably because females who report alcohol use after the fact and outside of prenatal clinics are more truthful , and their information more reliable.30,31 rates of alcohol consumption in other countries vary , with a higher prevalence being reported in many european countries and australia . for example , it was found in a french study that only 53% of females reported complete abstinence from the consumption of alcohol during pregnancy.32 alcohol was consumed by 22.7% of pregnant females in a spanish study,33 24.6% of the females admitted to an antenatal clinic in australia self - reported alcohol consumption during pregnancy,34 and 40% of females reported at least one episode of binge drinking since conception in a study in denmark.34 rates in other countries also vary considerably , with 57.4% of females in a prenatal clinic in chile reporting alcohol consumption during pregnancy35 and rates of 46.7% and 59% being reported in relation to prenatal alcohol consumption in two russian studies.36,37 it seems that alcohol consumption during pregnancy is generally lower in turkey than it is elsewhere . the authors speculated that cultural factors , especially religion , may play an important role in this regard . however , the high number of identified females who drink alcohol daily and who continue to do so during their pregnancy ( 50% [ table 1 ] ) suggests that a comprehensive investigation into substance addiction in females should be carried out during all routine polyclinic procedures . while only five females in this study reported using synthetic cannabinoids , two admitted to using these substances in their previous and current pregnancies . the turkish national police department of police anti - smuggling and organized crime reported that the rate of illicit drug use on at least one occasion was 2.7% . the prevalence of drug use was higher in young adults ( aged 1534 years ) than that in the general population ( aged 1564 years ) . most ( 95.2% ) deaths directly relating to drugs were male victims , with only 4.8% of these being females . these data show that drug use is more common in males.1 although fewer females use illicit drugs , to do so during pregnancy increases the health risks in both the mother and infant . in this study , synthetic cannabinoid users tended to maintain the use of synthetic cannabinoids during pregnancy and thus were identified as a group in particular need of guidance and counseling . in this study , only one female reported using biperiden , alprazolam , and similar drugs outside her pregnancy . other drugs were not used during pregnancy in this study , but in a study that was conducted in sivas , turkey , the rate of volatile substance use ( lifelong at least once ) was found to be 16.3% in females and 9.3% in males , and that for cannabis was 1.6% in females and 2.1% in males.38 the use of inhalants in another study was determined to be 9% in males and 1% in females , and 8% in males and 7% in females for other drugs.26 substance use was assessed in 1,082 pregnant females in sakarya province in this study , and none of the study participants reported the use of illicit substances , with the exception of synthetic cannabinoids , during their pregnancy . although the results reflect low illicit substance and drug use , this study was of a limited size and was conducted on a specific sample . thus , the results pertaining to illicit substance and drug use can not be generalized to other pregnant females in sakarya province . smoking during previous pregnancies and over a lifetime was established to be prognostic of smoking during the most current pregnancy . this result is similar to those reported in previous studies.21,39 the fact that lifelong alcohol use and its use during a previous pregnancy is predictive of tobacco use in a current pregnancy can be explained by the co - occurrence of tobacco use in alcohol users . both the lifelong use of alcohol and its use in previous pregnancies were determined to be prognostic of the use of alcohol in the current pregnancy . this result is also not surprising.40 nevertheless , it emphasizes the idea that alcohol and substance use in prepregnancy should be investigated and should act as a  red flag  to their potential use in a future pregnancy . smoking during pregnancy and lifelong smoking have been identified in numerous studies as being prognostic of alcohol use in the current pregnancy.4043 factors such as age , education level , number of pregnancies , and marital status were not determined to be prognosticators of alcohol or smoking use in this study . these variables have been reported as being predictors of substance use in some studies , but same results were not replicated / obtained in whole of the studies.21,40 further studies will help to determine certain risk factors for smoking , alcohol and substance abuse during pregnancy . the main limitations of this study were that it was based on self - reports and that while the frequency of alcohol and substance use was investigated , the daily amount consumed was not . in addition , addiction levels with respect to smoking and drinking were not determined through the use of a scale or clinical interviews . sakarya province is a main metropolitan area in turkey , but the modernization process in this area is not yet complete . the identities of this study participants were kept anonymous so that they were free to respond truthfully . this may explain the high rates of smoking , alcohol , and substance abuse identified in this study . the authors think that this was a key strength of this study . additionally , this is the first study of its kind to be carried out in turkey and the findings alcohol and synthetic cannabinoids are also risky substances whose use has been reported in pregnancy . it is recommended that physicians sensitively enquire about all forms of substance use in pregnant females admitted to clinics and specifically about smoking , alcohol , and synthetic cannabinoid usage . a need for similar studies to be conducted nationwide , and for pregnant females to be monitored methodically with respect to smoking , alcohol , and substance use , was identified in this study .
backgroundalcohol and substance use is a major health challenge in turkey , as it is worldwide . recently , there has been a rapid increase in the number of females using substances and although usage tends to reduce during pregnancy , it is of critical importance to determine its exact level as substance use negatively impacts on the health of both the mother and infant.aimthe aim of the present study was to investigate the frequency of smoking , alcohol , and substance use , and quitting rates during pregnancy.methodthis study was conducted on pregnant females in sakarya , turkey . 
 a total of 1,082 consecutively presenting females who agreed to participate in the study were evaluated . 
 the study team prepared a sociodemographic data form and adapted the  introduction  section , derived from the addiction profile index , to cover substance use during pregnancy.resultsthe substances most frequently used by pregnant females in their previous pregnancies and current pregnancies were cigarettes / tobacco products ( 11% and 11.8% , respectively ) , alcohol ( 0.6% and 0.4% , respectively ) , and rarely , synthetic cannabinoids ( 0.3% and 0.2% , respectively ) . 
 daily tobacco smokers continued to smoke during pregnancy , with a rate of 42.5% . based on research into predictors of smoking ( cigarettes ) in pregnancy , a correlation 
 was found between lifetime smoking and smoking during a previous pregnancy . 
 a similar link was found with respect to alcohol.conclusioncigarettes are the most frequently used substance in pregnancy , and to a lesser extent , alcohol and synthetic cannabinoids , also considered to be risky substances . 
 a high incidence of smoking regularly during pregnancy was found in daily smokers . 
 it is recommended that physicians should sensitively ask pregnant females presenting at clinics about all forms of substance use , including alcohol and synthetic cannabinoids , and to include such questions in their routine enquiries .