the pneumocococcal urine antigen test ( uat ) is an assay commonly used to identify pneumococcal antigens excreted into the urine to increase the rate of specific microbiological diagnosis over conventional culture methods [ 2 , 3 ] . positive tests have been associated with more severe disease including admission to the intensive care unit ( icu ) , in - hospital treatment failure and increased 30-day mortality . the binaxnow ( alere , waltham , ma , usa ) is the most common pneumocococcal uat utilised in the usa and , in a recent meta - analysis , it had a pooled sensitivity and specificity of 74.0% ( 95% ci 66.682.3% ) and 97.2% ( 95% ci 92.599.8% ) , respectively . data are limited regarding the test 's use and effect on antibiotic prescribing in clinical practice settings . the infectious diseases society of america / american thoracic society 2007 community - acquired pneumonia guidelines state that more research is needed regarding whether or not the pneumocococcal uat allows for narrowing of empiric antibiotic therapy to a single , specific antibiotic . two randomised , controlled trials examined the impact of pneumococcal uat testing on therapy choice with one of the studies showing increased rate of relapse among those treated with streptococcus pneumoniae - targeted therapy after positive uat [ 6 , 7 ] . .   demonstrated fewer side effects in a randomised controlled trial of pathogen directed therapy versus empirical , broad - spectrum antibiotics . the british thoracic society 2009 pneumonia guidelines recommend that the pneumocococcal uat only be performed on patients with moderate or high - severity pneumonia . we hypothesised that the pneumocococcal uat is often misapplied in clinical practice , becoming a needless expense without much added clinical benefit . we also hypothesised that its results are often ignored , with clinicians giving more heed to blood or sputum cultures . we therefore investigated the yield and impact of the pneumocococcal uat among emergency department patients with community - onset pneumonia admitted to seven utah hospitals . we performed a secondary analysis of electronic medical data from 2837 patients aged 18  years and older admitted with international diagnostic codes version 9 ( icd-9 ) and radiographic evidence of pneumonia evaluated in the emergency departments of seven intermountain healthcare hospitals . all patients were enrolled during two study periods : december 2009november 2010 and december 2011november 2012 . the gap year stems from the original purpose of this database to study impact of an electronic clinical decision support tool ; additional details have been previously published . cultures of blood and sputum , ordering of urinary antigens , and viral pcr panels were at the discretion of clinicians as part of usual care . standing orders instructed respiratory therapists to obtain tracheal aspirate for culture in patients for respiratory failure ; methods for reporting causative pathogens have also been previously described . these seven adult hospitals serve approximately half of the 2 million people residing in northern utah 's urban corridor . intermountain medical center is the largest of these hospitals , with 86  400 emergency department visits during 2012 , and is affiliated with university of utah residency programmes including emergency medicine and internal medicine . three of the hospitals are smaller community hospitals with fewer than 30  000 emergency department visits annually . standardised admission order sets for pneumonia patients included an order for uat , pre - selected for icu patients but requiring a check box for ward - admitted patients . mccauley ) manually reviewed medical records of patients with a positive pneumocococcal uat ( obtained at any time during the hospital admission ) to determine the test 's impact on antibiotic treatment . these authors collaborated extensively to promote standardisation and avoid duplication and misclassification of data and counselled with the senior author ( n.c . we classified change in antibiotic therapy as targeted ( single penicillin - class antibiotic such as penicillin , ampicillin , or amoxicillin ) , de - escalated ( decreased number of antibiotics and/or spectrum of antimicrobial activity ) or unchanged ( includes patients where additional antibiotics were administered ) . the study was approved by the intermountain healthcare institutional review board and the intermountain privacy board , and authorised by the utah population database . pearson 's chi - squared test was used to compare proportions and rates , and wilcoxon rank sum test was used to compare continuous , non - gaussian distributions . multivariable logistic regression was used to measure the effect of predictors on binary outcomes , with the hosmer  lemeshow goodness - of - fit test for model calibration . pearson 's chi - squared test was used to compare proportions and rates , and wilcoxon rank sum test was used to compare continuous , non - gaussian distributions . multivariable logistic regression was used to measure the effect of predictors on binary outcomes , with the hosmer  lemeshow goodness - of - fit test for model calibration . of 2837 emergency department patients admitted to the hospital with pneumonia , 1110 ( 39% ) underwent pneumocococcal uat yielding 134 positives ( 12% ) ( figure 1 ) . patients with healthcare - associated pneumonia ( hcap )   ( n=541 ) were less likely than those with community - acquired pneumonia ( n=2296 ) to have uat performed ( 33.1 versus 40.5% , respectively ; p=0.002 ) and less likely to be positive ( 8.4 versus 12.8% , respectively ; p=0.13 ) . of the 2837 patients , mean age was 64.2  years , 47.2% were male and 41.7% were admitted to the intensive care unit within 72  h of their emergency department visit . figure 2 shows the percentage of different pathogens identified by a combination of blood , sputum , tracheal aspirates , viral pcr and uat for pneumococcus and legionella . uat : urine antigen test ; cap : community - acquired pneumonia ; hcap : healthcare - associated pneumonia ; icu : intensive care unit . other  includes respiratory viruses , stenotrophomonas , prevotella , peptostreptococcus and other streptococcal species . in a multivariable logistic regression measuring the likelihood of obtaining a pneumocococcal uat , those younger in age , those with lower arterial oxygen saturation / inspiratory oxygen fraction ratios , and those admitted to the intensive care unit were more likely to undergo uat ( tables 1 and 2 ) . clinical parameters for community - acquired pneumonia patients stratified by whether a urine antigen test was obtained . data are presented as n ( % ) or median ( interquartile range ) , unless otherwise stated . scap minor is the number of minor criteria for severe community - acquired pneumonia from the infectious diseases society of america / american thoracic society 2007 community - acquired pneumonia guidelines 2007 and ecurb is the validated electronic version of curb-65 ( confusion , blood urea , respiratory rate , blood pressure , age 65 years ) with weighted , continuous variables yielding a point estimate for 30-day mortality [ 13 , 14 ] . patients admitted to the intensive care unit had a greater proportion of positive uat compared with those admitted to the hospital ward ( 15 versus 8.8% , respectively ; p<0.01 ) . on multivariable logistic regression , only those admitted to the intensive care unit were more likely to test positive ( or 1.84 , 95% ci 1.242.74 p=0.004 ) ( table 3 ) . clinical parameters for healthcare - associated pneumonia patients , stratified by whether a urine antigen test was obtained data are presented as n ( % ) or median ( interquartile range ) , unless otherwise stated . scap minor is the number of minor criteria for severe community - acquired pneumonia from the infectious diseases society of america / american thoracic society 2007 community - acquired pneumonia guidelines 2007 and ecurb is the validated electronic version of curb-65 ( confusion , blood urea , respiratory rate , blood pressure , age 65 years ) with weighted , continuous variables yielding a point estimate for 30-day mortality [ 13 , 14 ] . clinical parameters for patients with a positive uat , stratified by antibiotic therapy data are presented as n ( % ) or median ( interquartile range ) , unless otherwise stated . scap minor is the number of minor criteria for severe community - acquired pneumonia from the infectious diseases society of america / american thoracic society 2007 community - acquired pneumonia guidelines 2007 and ecurb is the validated electronic version of curb-65 ( confusion , blood urea , respiratory rate , blood pressure , age 65 years ) with weighted , continuous variables yielding a point estimate for 30-day mortality [ 13 , 14 ] . pao2 : arterial oxygen tension ; fio2 : fraction of inspired oxygen . in response to positive pneumococcal uat , physicians changed to targeted antibiotic therapy in 15% of cases ( n=20 ) with only one case of clinical relapse ( 5% ) ( figure 3 ) . reviewing that one case , follow - up cultures were negative and the relapse was attributed by treating clinicians to fluid overload . of the 20 patients receiving targeted therapy , 19 had blood cultures obtained with only two positive for streptococcus pneumoniae . we noted de - escalation of therapy in 76 ( 57% ) patients , the most common patterns being de - escalation from empiric therapy of vancomycin and pipercillin  tazobactam to ceftriaxone and azithromycin or simply discontinuing vancomycin . de - escalation occurred within 24  h of the uat result in 60 ( 62.5% ) patients , and was not associated with relapse . we noted no change in antibiotic therapy in 38 ( 28% ) patients , 13 of whom were already on ceftriaxone and azithromycin . length of stay was significantly lower among patients with targeted antibiotic therapy ( median 1.9 , ci 1.55.7 ; p=0.016 ) compared with de - escalated antibiotics ( 4.5 , ci 2.87 ) . inpatient mortality was significantly lower for patients with de - escalated antibiotic therapy ( 0% , n=0 ) compared with unchanged antibiotics ( 21% , n=8 ; p<0.001 ) . the binaxnow streptococcus uat costs $ 16.32 per the 2015 medicare pricing from centre for medicare and medicaid services . pneumococcal uat had a meagre positive yield overall of 12% ( 134 out of 1110 ) in emergency department pneumonia patients admitted to the hospital , but significantly higher yield in intensive care unit patients . in the 20 patients that received targeted anti - pneumococcal therapy , there were only two positive blood cultures , making the positive uat the only microbiological test in 18 patients to identify a causative organism . physicians changed antibiotic management in the setting of a positive uat in 72% of patients ( combining targeted and de - escalated therapy together ) . many of those without change in antibiotic were already receiving relatively narrow - spectrum ceftriaxone and azithromycin . the uat is inexpensive ; however , savings from de - escalating to targeted antibiotic therapy agents and experiencing fewer side effects from unnecessarily prolonged courses of broad - spectrum antibiotics may be substantial . while the yield is higher in intensive care unit patients , the low cost of uat and the willingness of physicians who ordered the test to deescalate antibiotics based on its result suggest that it also has utility in patients admitted to ward settings . our pessimistic hypothesis was therefore not confirmed by the findings of this study . with the help of uat , the pneumococcus was again the most commonly identified pathogen in patients admitted to the hospital with community - acquired pneumonia . the pneumococcus was identified in 52% of patients with an identified pathogen , 6% of the overall cohort of 2837 . by comparison , recent studies of hospitalised patients with pneumonia have reported 21% , 17% , 15.9% , and 5% caused by the pneumococcus [ 1518 ] . we found a low ( one ( 5% ) out of 20 ) relapse rate in those patients de - escalated to targeted therapy after positive uat ; even the one patient did not have relapse attributable to antibiotic de - escalation . similarly , an observational study by sorde 
 et al .   showed that simplified therapy based on the urinary antigen test enabled directed therapy in 41 ( 8.6% ) out of 474 of patients with community - acquired pneumonia without adverse effects . a prospective , randomised trial of 177 patients by falguera 
 et al .   showed that no difference in outcomes or adverse effects with targeted parenteral antibiotic therapy , although three ( 12% ) out of 25 patients changed to oral amoxicillin did relapse versus three ( 2% ) out of 150 other patients ; p=0.04 ) . a recent multicentre spanish study reported a 23% yield of the uat among 3865 pneumonia patients where 30  day mortality ( 6% ) and the rate of intensive care unit admission ( 7% ) were lower than in our study . molinos 
 et al .   derived predictors for a positive test , mostly factors associated with higher severity of illness . a similar analysis in our study resulted in the best prediction simply being intensive care unit admission . patients with risk factors for hcap were less likely to be tested , and had a lower rate of positive uat results . however , the positive yield of uat again documents the presence of usual , non - resistant pathogens among hcap patients . as hcap does not accurately select patients with resistant pathogens , and broad - spectrum antibiotic therapy does not improve their outcome , we do not recommend considering hcap factors in the decision to order pneumocococcal uat . the hcap concept was never adopted in europe , and is  mostly dead  in north america . our results may not be generalisable to other patient populations and hospitals since all seven hospitals are part of the same healthcare system located in a single geographic region . in addition , this is a secondary analysis of patients identified by icd-9 coding and radiographic evidence of pneumonia . however , we previously reported that our case definition had a sensitivity of 0.68 and specificity of 0.99 compared with pneumonia diagnosis by physician case review . finally , this study is based on a  real world  , observational database where the decision of a physician to order uat testing and act on its results were not influenced by the study team . this study supports the use of pneumocococcal uat testing as an inexpensive , noninvasive test that favourably influenced antibiotic prescribing . with increasing concern regarding antibiotic stewardship , study , we encourage physicians to target antibiotic therapy towards streptococcus pneumonia even if the uat is the only positive microbiologic test . our results may not be generalisable to other patient populations and hospitals since all seven hospitals are part of the same healthcare system located in a single geographic region . in addition , this is a secondary analysis of patients identified by icd-9 coding and radiographic evidence of pneumonia . however , we previously reported that our case definition had a sensitivity of 0.68 and specificity of 0.99 compared with pneumonia diagnosis by physician case review . finally , this study is based on a  real world  , observational database where the decision of a physician to order uat testing and act on its results were not influenced by the study team . this study supports the use of pneumocococcal uat testing as an inexpensive , noninvasive test that favourably influenced antibiotic prescribing . with increasing concern regarding antibiotic stewardship , study , we encourage physicians to target antibiotic therapy towards streptococcus pneumonia even if the uat is the only positive microbiologic test .
the pneumocococcal urine antigen test increases specific microbiological diagnosis over conventional culture methods in pneumonia patients . 
 data are limited regarding its yield and effect on antibiotic prescribing among patients with community - onset pneumonia in clinical practice.we performed a secondary analysis of 2837 emergency department patients admitted to seven utah hospitals over 2  years with international diagnostic codes version 9 codes and radiographic evidence of pneumonia.mean age was 64.2  years , 47.2% were male and all - cause 30-day mortality was 9.6% . 
 urinary antigen testing was performed in 1110 ( 39% ) patients yielding 134 ( 12% ) positives . 
 intensive care unit patients were more likely to undergo testing , and have a positive result ( 15% versus 8.8% for ward patients ; p<0.01 ) . 
 patients with risk factors for healthcare - associated pneumonia had fewer urinary antigen tests performed , but 8.4% were positive . 
 physicians changed to targeted antibiotic therapy in 20 ( 15% ) patients , de - escalated antibiotic therapy in 76 patients ( 57% ) . in 38 ( 28% ) 
 patients , antibiotics were not changed . 
 only one patient changed to targeted therapy suffered clinical relapse . 
 length of stay and mortality were lower in patients receiving targeted therapy.pneumococcal urinary antigen testing is an inexpensive , noninvasive test that favourably influenced antibiotic prescribing in a  real world  , multi - hospital observational study .