granular cell tumors were first described as myoblastoma by abrikossof in 1926 . this tumor is rare , usually benign and of neuroectodermic origin in the schwann cells . it has been described at multiple locations and is the second greatest cause of esophagheal mesenchymal tumors , after leiomyoma . eosinophilic esophagitis ( ee ) is a clinicopathological entity which is allergic in origin and was characterised by attwood in 1993 . this is the first documented case of a patient suffering from both entities , who was diagnosed via digestive endoscopy and biopsy . a 41-year - old male with a history of allergic asthma since childhood , rhinoconjunctivitis and sensitivity to pollen , attended the gastroenterology clinic having suffered from progressive dysphagia on an infrequent basis over a number of years . the patient described symptoms of a retrosternal lump , and felt as if something were blocking the passage of food in his esophagus . these episodes varied in length and subsided of their own accord after several minutes without requiring endoscopic intervention . the symptoms had recurred on a number of occasions and were not linked to any specific food type . he showed no signs of nausea , regurgitation , pyrosis , abdominal pain or weight loss . after an endoscopy was carried out , a tumor was detected in the upper third of the organ which was submucosal , yellowish in color , molar - shaped and hard to the touch using the biopsy tweezers . it measured approximately 5 mm , did not restrict the passage of the endoscope and was coated in normal mucosa ( fig . the biopsies showed that the submucosal esophageal stroma were infiltrated by nests of cells with ample , granular eosinophilic cytoplasms with central nuclei and showed no indication of atypia or mitosis , in line with esophageal granular cell tumor ( fig . the patient had similar symptoms to those related to this type of lesion , and because the tumor was small and the histology showed no indication of malignity , we decided to carry out endoscopic and histological monitoring . two years later , the patient was still being attended for episodic dysphagia . during the endoscopic review , performed at that time , the submucosal tumor was once again detected in the upper third , showing no changes . regular stenosis was also identified in the junction between the upper and middle esophageal thirds which had gone undetected during the previous exploration and was passable under gentle endoscopic pressure . the mucosa of the middle and distal esophagus appeared edematous with a loss of normal vascular pattern and had various longitudinal striae along the folds . the biopsies taken from this area showed epithelial edema , acanthosis and papillomatosis , with dense eosinophilic leucocyte infiltration , by more than 24 eosinophils per high - power field , findings compatible with ee ( fig . biopsies were also taken of the tumor in the upper third which still seemed to be benign . the rest of the stomach and duodenum exploration was normal and the biopsies taken from the antral mucosa did not show any alterations . the patient was subjected to an ambulatory 24-hour ph - metry , which ruled out pathological gastroesophageal reflux as a possible cause of eosinophilic infiltration of the esophagus , and a stationary esophageal manometry was also performed with the following results : upper esophageal sphincter with normal pressure and pharyngeal coordination , normal pressure and complete relaxation of the lower sphincter . the esophageal body had 20% non - transmitted waves in the 3/3 , 10% non - transmitted waves in the upper 2/3 with normal amplitude in the distal third and 70% peristaltic waves of normal duration with increased amplitude in the distal third . upon diagnosis of ee , treatment of topical fluticasone propionate was administered , applied on the tongue using an inhaler device and then swallowed , at a dosage of 500 g every 12 h. the patient was recommended not to eat and drink for several hours after the application of treatment and to rinse out his mouth with water and bicarbonate of soda 20 min after taking the medication . he was subsequently referred to the allergy clinic to be examined for possible sensitivity to food or airborne allergens . after three months of treatment , the patient showed substantial clinical improvement and the episodes of dysphagia had subsided . the esophageal mucosa had returned to normal ( except for the tumor in the upper third ) and the mucosal biopsies showed resolution of the eosinophilic infiltrate and of the histological changes . the manometry which was repeated following treatment showed normalisation of the motor function of the esophagus , with 100% peristaltic waves of normal duration and amplitude in the three thirds . endoscopic exploration is a basic technique in the study of dysphagia . in young patients , it is mainly caused by benign disorders associated with acid reflux exposure , leading to very rare malignant neoplasias . in recent years , we have witnessed a considerable rise in the number of reported cases of ee , to the extent that this emerging entity should also be included in the differential diagnosis of dysphagia , especially in young patients with a background of allergies . granular cell tumor or abrikossoff 's tumor is a rare lesion deriving from the schwann cells of the submucosal plexus neurons of the esophagus of which less than 300 cases have been documented . most reported cases have involved single lesions located in the distal third , mainly affecting women in their fifties , characteristics which were not met by our patient . although this pathology is usually benign , a few exceptional cases of malignant tumors have been reported , with distant ganglionary metastasis , and these required obligatory histological analysis to rule out this possibility . certain instances of granular cell tumors synchronically or metachronically linked to malignant neoplasias of the esophagus have also been documented , such as adenocarcinomas or squamous carcinomas [ 7 , 8 , 9 ] , although the actual extent of this association is unknown . to date , no cases of granular cell tumors linked to ee have been reported , meaning that our case is the first . nevertheless , because both disorders suffered by the patient are unrelated in origin ( mucosal hypersensitivity and tumoral proliferation of schwann cells ) , we believe that association is coincidental . given that most esophageal granular cell tumors are small ( < 1 cm ) , diagnosis tends to occur accidentally during endoscopic exploration carried out for another purpose . from the start , our patient 's symptoms definitely matched those of ee , but because information on this entity has only recently become available and endoscopic findings are often not very obvious , going undetected by the non - expert , it is likely that the patient 's initial diagnosis was incorrect . ee can be associated with a wide range of endoscopic patterns , including concentric , focal or segmentary stenosis , simultaneous contractions , rings along the organ or subtle findings described regarding the mucosal appearance . a recent review has established that the most common endoscopic findings described in the literature linked to ee were white stipple - like exudates , linear fissures and reddening , but mucosa was regarded as normal in near a quarter of patients . the extensive polymorphism on the endoscopic findings characterizing ee was classified in a recent work according to a manometric and histopathological relationship : alterations in the esophageal calibre can be related with motor disturbances affecting the two distal thirds of the organ , while varying degrees of intensity in histological damage induced by activation and degranulation of eosinophilic leukocytes lead to different endoscopic patterns , which could be classified in 4 well - defined categories : granular , corrugated , undulated and exudative . as regards treatment alternatives for ee , children following basic diets ( lacking in antigenic capacity ) over an 8-week period showed improved symptoms in addition to histological normalisation . because this measure is difficult to apply to adults , we decided to opt for pharmacological treatment for our patient . among these options , systemic action glucocorticoids [ 13 , 14 ] proved to be efficient given clinical , endoscopic and histological - type parameters , although they have potential side effects . topical corticoids such as fluticasone propionate administered by inhaler are effective and , compared to systemic corticoids , do not have any side effects and are widely used to treat ee in children [ 15 , 16 , 17 , 18 , 19 ] and adults [ 20 , 21 ] . although some reports discuss the use of sodium cromoglycate and antileukotrienes [ 22 , 23 ] in the treatment of ee , these cases are isolated due to limited experience . after 3 months of treatment with fluticasone propionate , we noticed considerable improvement in symptoms such as remission of dysphagia , less time required in having lunch and dinner , as well as resolution of the esophageal inflammatory infiltrate and normalisation of epithelial histological changes . manometric alterations of the esophagus reverted following treatment , as proof of their functional nature . possible therapeutic alternatives for granular cell tumors include endoscopic resectioning of the lesion using a variety of procedures , surgical resectioning and an expectant or conservative approach   to endoscopic and biopsy monitoring every 6 to 12 months . the latter attitude is the most frequently adopted in literature and is that which is currently recommended for lesions which are generally benign and where malignisation is rare . provided that the tumor fulfils certain benign criteria , in that it is small ( < 10 mm ) , asymptomatic , does not have a histology of mitosis or dysplasia or changes in size , periodic monitoring can be employed , as this is the safest option with the best cost / efficiency relationship . considering these characteristics , we adopted a conservative approach towards the abrikossoff 's tumor identified in our patient . to conclude , this is the first documented case of the link between granular cell tumors and ee . although both entities are lesions of a different nature and physiopathological origin , they are both interesting pathologies that should be considered during the endoscopic examination of dysphagia in young patients .
we illustrate the case of a 41-year - old male with allergic manifestations since childhood . 
 he sought medical attention for intermittent , progressive dysphagia from which he had been suffering for a number of years , having felt the sensation of a retrosternal lump and a self - limited obstruction to the passage of food . 
 endoscopy detected a submucosal tumor in the upper third of the esophagus , which was typified , via biopsy , as a granular cell tumor with benign characteristics and probably responsible for the symptoms . 
 two years later , the patient sought medical attention once again as these symptoms had not abated , hence digestive endoscopy was repeated . 
 this revealed stenosis of the junction between the middle and lower thirds of the organ which had not been detected previously but was passable under gentle pressure . 
 eosinophilic esophagitis was detected after biopsies were taken . 
 esophageal manometry identified a motor disorder affecting the esophageal body . 
 following three months of treatment using fluticasone propionate applied topically , the symptoms went into remission , esophageal stenosis disappeared and the esophageal biopsies returned to normal . 
 this is the first documented case of the link between granular cell tumors and eosinophilic esophagitis , two different disorders which could cause dysphagia in young patients .