the clinical course of our patient , who sustained remission status for at least 18 months highlights the chance of long - term hormonal and tumor remission and demonstrates the efficacy and safety of discontinuation of temozolomide therapy . prospective studies are required in order to define predictors of long - term remission of this promising therapeutic modality .
key clinical messagethe clinical course of our patient , who sustained remission status for at least 18 months highlights the chance of long - term hormonal and tumor remission and demonstrates the efficacy and safety of discontinuation of temozolomide therapy . 
 prospective studies are required in order to define predictors of long - term remission of this promising therapeutic modality .