a 78-year - old man presented to our hospital with an extensive tumor located on the right thigh ( figure 1a - b ) . a , b : mrt of the right thigh , transversal scan t1 and t2 respectively . c : he - staining of a diffuse proliferation of large lym phoid cells which have totally affected the normal architecture of striated muscle . d : the neoplastic cells express pan - b - cell markers such as cd 20 . the patient reported that he had been treating the fast growing tumor with complementary medicine for 6 weeks prior to consulting our hospital . histopathological examination of a biopsy revealed diffuse proliferation of large lymphoid cells which have totally affected the normal architecture of striated muscle ( figure 1c-1d ) . the medium- to large sized neoplastic cells expressed pan b - cell markers such as cd 20 corresponding to an extra nodal diffuse large b - cell lymphoma . our patient received multimodality treatment including chemo therapy of the chop scheme and adjuvant radiotherapy . diffuse large b - cell lymphoma ( dlbcl ) can affect any age group but occurs mostly in older people . it usually starts as a quickly growing mass in an internal or superficial lymph node and can infiltrate other areas such as the intestine , bone , or even the brain or spinal cord . about 1 out of 3 of these lymphomas is confined to one part of the body when it is found . localized lymphomas are easier to treat than when they have spread to other parts of the body . there are different genetic subtypes of dlbcl , even though they look the same under the microscope . this is a fast growing lymphoma , but it often responds well to treatment with radio - chemotherapy . overall , about 3 out of 4 people will have no signs of disease after initial treatment , and about half of all people with this lymphoma are cured with therapy [ 1 - 4 ] .
diffuse large b - cell lymphoma usually starts as a rapidly growing mass in an internal lymph node and can grow in other areas such as the bone or intestines . 
 about 1/3 of these lymphomas are confined to one part of the body when they are localized . in the case of a 78-year - old man , 
 an extensive tumour was located on the right thigh . 
 biopsies of the tumour revealed diffuse proliferation of large lymphoid cells which have totally affected the normal architecture of striated muscle . 
 the patient received multimodality treatment including chemotherapy of the chop regimen and adjuvant radiotherapy . despite this being a fast growing lymphoma 
 , about 3 out of 4 people will have no signs of disease after initial treatment , and about half of all people with this lymphoma are cured with therapy .