the present research work was undertaken to design low - cost modified release ( 24 h ) tablets of metoprolol succinate using hpmc k15 m and eudragit ( rlpo and rspo ) as a matrixing agents . the reason of using combinations of such polymers was to overcome the disadvantages of individual matrix forming agents . tablets were made by using metoprolol ( 100 mg each tablet ) , hpmc ( release retardant hydrophilic polymer ) , eudragit and lactose , by wet granulation process with pvp k30 ( in isopropyl alcohol ) . compression was done on a 10 station tablet machine ( rimek mini press india ) . the effects of polymer on drug release were studied in ph 1.2 buffer using usp type ii apparatus at 50 rpm . drug release and drug content was analyzed spectrophotometrically at 272 nm ( uv spectrophotometer , jasco ) with validated uv method . all the batches were evaluated for weight variation , hardness , friability , assay and found within acceptable limits of pharmacopoeia . in - vitro drug release characterized with dissolution testing in electro lab usp apparatus with 1.2 ph buffers . it showed that drug release was very retarded in f-1 due to high proportion of eudragit and hpmc polymers . formulation f-2 release was slower that f-4 because of low permeability of rspo than rlpo . equal proportion ( 1:1 ) of rspo and rlpo made an optimum permeability for drug release from matrix . the data obtained from in - vitro dissolution studies were fitted in different models viz . it can be concluded formulation with desired drug release achieved with combination of eudragit rlpo and rspo in ratio of 1:1 . the addition of gel forming polymer ( hpmc ) were essential to achieve stable and persistent gel formed by hydration of hpmc polymer . the results of present investigation shows the prepared metoprolol tables were found to have good controlled release properties with controlled non - fickian diffusion .
metoprolol succinate is a selective beta - adrenergic receptor blocker useful in treatment of hypertension , angina and heart failure . 
 the purpose of the present work was to design and evaluate controlled release matrix type tablet of metoprolo succinate using hpmc k15 m and eudragit ( rlpo and rspo ) as a matrix forming agents . 
 effect of various polymer alone and combinations were studied in ph 1.2 buffer using usp type ii paddle at 50 rpm . 
 hpmc was used to form firm gel with eudragit polymer . 
 formulation with equal proportion ( 1:1 ) of eudragit rspo and rlpo showed optimum drug release t50=7 hrs and t100=16 hrs indicate optimum permeability for drug release from matrix . 
 the drug release mechanism was predominantly found to be non - fickian diffusion controlled .