before 1993 , the former viruses of present norovirus were diagnosed by means of electron microscopy using stool samples . they were called in the literature , according to their shape ,  small round structured virus ( srsv ) , or due to their similarity to the norwalk agent ( norwalk - like viruses ) were named after the location where they were found . after sequencing was accomplished , the broad sense of norwalk - like virus genome revealed a single positive - strand rna enclosed in a non - enveloped protein coat with distinct cup - shaped depression that placed it as a new genus norovirus in the family caliciviridae , whose name is derived from calyx , meaning cup in greek . norovirus is now recognized as being the leading cause of epidemics of gastroenteritis and an important cause of sporadic gastroenteritis in both children and adults . a recent review of studies documented norovirus in 531% of patients hospitalized for gastroenteritis and in 536% of those visiting a clinic , making it the most common cause in children . we report the case of a healthy female with acute norovirus gastroenteritis who developed acute liver damage during the infectious gastroenteritis . she described the pain as intermittent dull pain in the whole abdomen without any exacerbating or relieving factors , which radiated to the back , shoulder , and neck . she had a medical past history of cholelithiasis and had undergone cholecystectomy 4 years before . she drank a can of beer every day , but liver damage had not been pointed out . she had eaten raw fish 5 days before onset of this illness , but she denied any ingestion of oyster , raw shellfish , raw pork , or venison . she felt acute moderate distress of the whole abdomen , but physical examination showed soft abdomen , tenderness especially in epigastrium and right hypochondrium ; murphy 's sign phenomenon was unclear . no dilation of the common bile duct or bile duct stone was found ; the intrahepatic bile duct and the pancreatic duct were normal . we could thus exclude an episode referring to her past history . however , laboratory values on admission ( table 1 ) showed moderate elevation of aspartate aminotransferase ( ast ) up to 651 iu / l , alanine aminotransferase ( alt ) up to 146 iu / l , lactate dehydrogenase ( ldh ) up to 457 iu / l , but there was no elevation of total bilirubin ( t - bil ) , direct bilirubin ( d - bil ) or alkaline phosphatase ( alp ) . other hepatitis viruses such as hav and hev were all negative , and other viruses which can cause liver dysfunction were not detected . we confirmed that epstein - barr virus , cytomegalovirus and human herpesvirus were negative . on the second hospital day , ast rose up to 892 iu / l and alt up to 445 iu / l . the same day , watery diarrhea more than 10 times daily occurred . on the third hospital day , the laboratory values peaked out , and on the fourth day , the symptoms improved ( fig . stool culture for pathogenic bacteria turned out to be negative , and norovirus was detected by viral antigen check and confirmed by reverse transcription polymerase chain reaction . other enteric pathogenic viruses such as rotavirus , adenovirus , astrovirus , norovirus or sapovirus were not detected . the patient recovered satisfactorily by supportive therapy and was discharged on the 7th hospital day , with improvement of liver dysfunction as ast 98 iu / l and alt 30 iu / l . her liver damage was normalized completely on the 14th day as ast 32 iu / l and alt 30 iu / l . human norovirus has been most recently established compared to other enteric viruses such as rotavirus , adenovirus and astrovirus . its infectious potential is estimated to be very high among these viruses ; it is one of the most prevalent enteric viruses causing acute gastroenteritis in children of all ages . the virus is sometimes thought to lead to whole body infection . there was a report that murine norovirus infection of mice is associated with initial enteric seeding and subsequent extraintestinal spread , and other reports followed . while it has long been believed that norovirus infection is confined to the intestine , there is no direct proof for this claim , and several recent findings   suggest that this theory be re - considered . a work in animal models of norovirus infection supports virus dissemination past the intestine , too . murine norovirus 1 ( mnv-1 ) replicates efficiently in the spleen and induces specific splenic histological changes , including activation of cells in the white pulp and hypertrophy of cells in the red pulp . as norovirus diagnostics have improved , there have been numerous reports of norovirus associations with clinical outcomes other than gastroenteritis . for example , one case report detected norovirus rna in the serum and cerebrospinal fluid of a child with encephalopathy . in addition , central nervous system damages during a norovirus outbreak among military personnel in afghanistan were reported . the possibility that human noroviruses disseminate to peripheral sites is a clinically relevant question , since mild or sporadic pathologies associated with human norovirus infection of peripheral tissues may have been missed due to difficulties in their detection and the assumption that they are limited to the intestinal tract . there have been several recent associations between norovirus infection and extraintestinal involvement showing disseminated intravascular coagulation   and infantile convulsion [ 9 , 10 ] . however , there is no report of liver damage   caused by norovirus infection , only of rotavirus hepatitis in a child . referring to viral hepatitis , the concurrent presence of norovirus and hepatitis a virus was pointed out and potential risk of hepatitis was worried about [ 6 , 11 ] . as we could exclude all other causes for liver damage , we report the case of a normal adult female with acute norovirus gastroenteritis who developed acute liver damage during infection . we also speculate that there may be low - grade damage of liver function in norovirus gastroenteritis , but we might not catch occasionally the minimal changes before they disappear after a short period . to evaluate the liver dysfunction forward to further argument , we should pay attention not only to intestinal symptoms , but also to liver function in viral gastroenteritis . while this case report provides only anecdotal evidence that norovirus infection can have varied clinical outcomes , it adds proof suggesting that enteric viruses should be considered as potential etiological agents of diseases other than gastroenteritis .
a 48-year - old female with abdominal pain and malaise who showed delayed symptom of acute gastroenteritis came to see us . 
 her illness was diagnosed as norovirus infection , but liver dysfunction accompanied this gastroenteritis . 
 we investigated the pathogenesis of this hepatitis for all causes including drugs , but we could not detect norovirus infection . the liver damage improved shortly in course of the gastroenteritis . 
 she recovered completely within 2 weeks without any damage left . 
 norovirus - induced liver dysfunction is not known , and there is no report in the literature . 
 we report , for the first time , the case of liver dysfunction with norovirus gastroenteritis .