inflammatory pseudotumor ( ipt ) is an uncommon benign lesion histologically defined as a localized mass consisting of dense fibrous tissue infiltrated by inflammatory cells . liver ipt may clinically and radiologically mimic malignant liver tumors . therefore , surgical resection and histopathologic study are often unavoidable for establishing the diagnosis . the authors present a case of infiltrating liver ipt , which was diagnosed by fine - needle sampling and histopathologic examination . a 52-year - old woman presented at our hospital ( alzahra hospital , isfahan university of medical sciences ) for evaluation of fever of unknown origin . she had a 1-year history of intermittent fever , night sweating , and myalgia . following abdominal computed tomography ( ct ) scan showed infiltrative lesion in the right hepatic lobe [ figure 1 ] . in the subsequent step , the patient underwent a ct - guided needle biopsy of hepatic lesions . abdominal computed tomography scan with contrast showing diffuse infiltrating lesion in right hepatic lobe on microscopic evaluation of the biopsy specimen infiltration of chronic inflammatory cells and lymphoplasma cells in portal spaces with mild penetration to hepatocytes there was also lytic necrosis and confluent necrosis and dilatation of some portal spaces due to fibrosis . tumor markers were all within normal range except for serum cancer antigen 19 - 9 ( ca 19 - 9 ) , which was slightly increased . the patient was discharged and an outpatient followup was arranged . after 6 months she had no complaint of fever or malaise and control liver ultrasonography disclosed no lesion . liver ipt is considered a benign inflammatory lesion , mostly presented as a solitary solid mass in the right hepatic lobe . multifocal liver ipts were also reported , but infiltrating ipt , which was seen in the present case , is very rare . despite several theories suggesting the possible etiology of liver ipt infectious agents , autoimmune factors , and inflammatory effect of the biliary steroid lithocholic acid are some of the suggested etiologies . patients may present with fever , upper abdominal pain , weight loss , and jaundice . liver ipt is an uncommon differential diagnosis of fever of unknown origin ( fuo ) . however , as most of the cases of liver ipt , such as the present case , have been described with prolonged fever , this condition should be considered in differential diagnosis of all patients with fuo . histopathologic features of ipts include the presence of myofibroblastic spindle cells infiltrated by plasma cells and chronic inflammatory cells without cellular anaplasias or atypical mitoses . in our patient , interestingly , there are some evidences suggested that liver ipt itself may increase serum ca19 - 9 . ultrasound , ct scan , and magnetic resonance imaging of liver ipt have revealed various patterns , probably due to various proportions or the distribution of histologic components in different cases . liver ipt may also both clinically and radiologically mimic a hepatocellular carcinoma , cholangiocarcinoma , hepatic metastasis , or a liver abscess . diagnosis of liver ipt by fine - needle biopsy , which was carried out in the present case is very beneficial . indeed , with the help of clinical manifestations , imaging findings , level of serum tumor markers , and results of histopathologic examination of specimens obtained from fine - needle biopsy , we may reach to the diagnosis of liver ipt . following the diagnosis , as the liver ipt has a favorable response to conservative therapy and may also resolve spontaneously , followup or conservative therapy should be the first line of management . antibiotics , nonsteroidal anti - inflammatory drugs , steroids , and biliary drainage are the options of conservative therapy . surgical resection should be reserved for cases where the diagnosis is uncertain , the patient does not respond to conservative therapy , or in the presence of severe complications . in conclusion , liver ipt should be considered in the differential diagnosis of both fuo and mass lesions of the liver . after proper evaluation for exclusion of malignancy , followup or conservative therapy should be the first line of management , and surgical resection should be reserved for uncertain diagnosis or failure of conservative therapy .
liver inflammatory pseudotumor ( ipt ) is considered a benign inflammatory lesion mostly presented as a solitary solid mass in the right hepatic lobe . 
 it may clinically and radiologically mimic a malignant liver tumor or an abscess . 
 accordingly , diagnoses of most of the reported cases have been established after surgical resection . in this report 
 , we describe a 52-year - old woman with a 1-year history of fever of unknown origin . in the following investigation , 
 abdominal computed tomography ( ct ) scan showed infiltrative lesion in the right hepatic lobe . 
 the patient underwent a ct - guided needle biopsy of the hepatic lesion . 
 histopathologic study of biopsy specimen revealed the features of ipt . 
 the patient was discharged and followedup for 6 months . 
 after 6 months she had no complaint of fever and control liver ultrasonography disclosed no lesion . as liver ipt has favorable response to conservative therapy and may also resolve spontaneously , precise recognition of this condition with the help of fine - needle biopsy may help to avoid unnecessary surgery .