leukemia , a cancerous disease of the white blood cells spreads throughout the bloodstream and may affect a number of organs 1 . it begins in the bone marrow , where all blood cells are formed before being released into the bloodstream . leukemia may present in different forms and are distinguishable per the form of abnormal leukocytes and by how quickly these cells leave the bone marrow and enter the bloodstream . the four main types of leukemia are acute myeloid leukemia , chronic myeloid leukemia , acute lymphoblastic leukemia , and chronic lymphocytic leukemia 2 . acute myeloid leukemia ( aml ) is the most common type of leukemia that affects adults . chronic leukemia habitually develops gradually , and is characterized by reasonably higher proportions of mature cells . these reasonably high proportions of mature cells help sustain some of their customary functions 1 . the peak incidence of chronic myeloid leukemia is 3.110.1 per 100,000 people for those aged between 6084 , but decreases to 0.5 per 100,000 people for the 2024 group 1 . chronic myeloid leukemia ( cml ) results from an acquired or a genetic insult to the dna of a single bone marrow cell . chronic myeloid leukemia does not fully hinder the formation of mature red cells , white cells , and platelets . as a consequence , chronic phase of myeloid leukemia is usually less fatal than acute leukemia , and more often than not patients diagnosed are asymptomatic . most cases occur above 50  years with a median age of diagnosis of 64 , but rarely occur in a young adult 1 . clinically evident ocular involvement is common in patients with leukemia and has been described in up to 50% of patients at the time of diagnosis 3 . leukemic retinopathy is characterized by multiple preretinal and intraretinal hemorrhages that are most notably present in the posterior pole . other clinical signs comprise : roth 's spots , cotton wool spots , exudates , retinal venous tortuosity , perivascular sheathing , and neovascularization . roth 's spot hemorrhages may point to a small area of retinal leukemic infiltration or platelet  fibrin depositions . retinal lesions of peripheral neovasularization or  sea fan  neovascularization ( typical of sickle cell retinopathy ) may occur in patients with chronic leukemia and are thought to occur as a result of peripheral nonperfusion and ischemia from the hyperviscosity 3 . this is a case of leukemic retinopathy resulting from chronic myeloid leukemia , which mimics ischemic retinopathies in a young adult . a 20yearold man presented to the university of cape coast optometric clinic for routine eye examination as part of the university 's health screening program for fresh students . snellen visual acuities recorded with his habitual correction was 6/5 in each eye , and his unaided visual acuities were 6/6 and 6/12 in the right and left eyes , respectively . his near acuity , both aided and unaided were n5 at 40  cm in each eye . the cup to disc ratio was 0.2 , but there were blot and dot hemorrhages on the perifoveal area approaching the posterior pole of the right eye , roth 's spots , and cotton wool spots . there was also the presence of venous dilation in the superior quadrant of the fundus . the cup to disc ratio for the left eye was 0.3 with similar hemorrhagic fundal presentation as found in the right eye except that more of the hemorrhages in the left eye were located at the midperiphery ( fig .  1 ) . fundus picture highlighting the degree of perifoveal hemorrhages in the right and left eye , respectively . this ophthalmoscopic findings prompted further questioning which revealed that he had been experiencing excessive sweating especially at night , occasional bone pain , tiredness , and inability to tolerate aerobic exercise for the past 3  months prior to his visit . further assessment including blood pressure and pulse rate measurement were consistently normal when taken on four different occasions about the same time . fasting blood sugar , fbs was also within normal range ( 5.1  mmol / l ) , however , glycosylated hemoglobin of 6.2% indicated prediabetic tendencies ( normal : 46% , prediabetes 6.16.4% ) . an initial complete blood count showed a low hematocrit levels ( 37.1% as against an expected normal of 4052% ) and a high red blood cell distribution width of 15.9% ( normal : 1014% ) . red blood cells levels were low ( 4.0    10/l as against the expected normal of 4.405.90    10/l ) and white blood cells count was high 56.8    10/l ( normal : 310.6    10/l ) . lymphocytes count was 18.6    10/l ( normal : 0.83.9    10/l ) and granulocytes count was 35.5    10/l ( normal : 1.17.8    10 cells count ( including less frequently occurring cells correlating to monocytes , eosinophils , basophils , blast , and other precursor cells ) was 2.7    10/l ( normal range : 0.01.5    10/l ) . a repeat of complete blood count a week afterwards revealed a consistent decline in hematocrit levels ( 33.2% ) , but a high red blood cell distribution width of 19.8% , a low red blood cell count of 3.96    10/l , white blood cell count of 160    10/l , lymphocytes count of 17.4    10/l , granulocyte count was 35.5    10/l . the other formed blood elements were normal except mean corpuscular hemoglobin concentration that was elevated in the second complete blood count , 39.2    10/l ( normal : 3236    10/l ) . the platelets count were consistently within normal limits , but decreased from 234    10l to 157    10  l ( normal : 150400    10/l ) . erythrocyte sedimentation rate ( esr ) was high 16  mmfall / h ( normal : 010 ) , however , blood culture revealed no microbial growth after 5  days . peripheral blood smear revealed mainly normocytic , normochromic cells along with numerous myeloid cells and neutrophilic band cells . hypertensive and diabetic retinopathies were among the differential diagnosis , but were ruled out because of the presence of roth 's spot , consistently normal blood pressure , pulse rate , fasting blood sugar and glycosylated hemoglobin 4 . the roth 's spots are typical of retinopathy due to anemia , leukemia , and bacterial endocarditis . however , infective endocarditis was ruled out because blood culture result revealed no microbial growth . the hematological profile of low hematocrit levels , high red blood cell distribution width together with low red blood cell count amidst the fundus findings was suggestive of anisocytotic anemia . nevertheless , some prospective studies of leukemic patients have established an association between acute leukemia and intraretinal hemorrhages , high white blood cell count , roth 's spots and declining , or low platelet count 5 . again , anemia could occur secondary to leukemia , hence , the existing ischemic retinopathy could not be solely attributed to anemia . the rapid increase in white blood cell count on two separate occasions with revealing high differentials and the presence of myeloid cells and neutrophilic band cells on peripheral blood smear amidst the fundus findings , barring any evidence of infection upon blood culture , led to a tentative diagnosis of leukemic retinopathy from a possible chronic myeloid leukemia . at this stage , the patient was counseled and referred to a hematologist for further assessment in a bid to confirm the tentative diagnosis . the patient was noncompliant as he reported after a month with a complaint of blurred vision in the left eye . assessment revealed a presenting visual acuity of counting fingers ( cf ) at 30  cm in the left eye and 6/5 in the right eye . fundus examination revealed subretinal hemorrhage at the macula area leading to complete loss of foveal reflex in the left eye . hematology visit was arranged immediately . full blood count with differential at hematology visit revealed white blood cell count of 421.72    10/l ( normal range:(2.508.50 ) 10/l ) along with neutrophil count of 352.32    10/l ( normal range : 2.07.0    10/l ) , lymphocyte count of 11.81    10/l ( normal range : 1.03.0    10/l ) , monocyte count of 13.08    10/l ( normal range : 0.21.0    10 ) , eosinophil count of 21.66    10/l ( normal range : 0.040.4 10/l ) , basophil count of 22.50    10/l ( normal range : 0.020.1    10/l ) . fluorescence in  situ hybridization ( fish ) was done on the peripheral blood cells and bcrabl was detected . the patient was immediately put on an oral hydroxyurea 1.5  g twice daily for a week and oral alluprinol 300  mg daily for 2  weeks . after 2  months of treatment with hydroxyurea , patient 's complete blood count was determined again and the result were as follows : white cell count , 1.78    10/l ( normal : 2.508.5    10/l ) , neutrophil count , 0.69    10/l ( normal : 2.007.00    10 ) , lymphocyte count , 0.55    10/l ( normal : 1.003.00    10/l ) , monocyte count , 0.11    10/l ( normal : 0.201.00).this later findings was indicative of improved patient condition per the treatment given . the persistence of anemia as indicated by the red blood cell count of 3.23    10/l ( normal : 3.505.50 ) and hematocrit level of 28.9% ( normal : 36.054.0 ) was expected with hydroxyurea treatment . the foveal reflex in the left eye was restored with aided visual acuity of 6/18 in the left eye and 6/5 in the right eye . understanding of ocular association in leukemia is essential as the eye serves as the distinct site where leukemia 's impact on nerves and blood vessels can be straightforwardly noticed . ocular associated symptoms may sometimes serve as the initial mode of presentation of this systemic disease in 3.6% of patients with the disease conditions 6 . ocular complications of leukemia is known to be due to direct infiltration of the orbit and other tissues ( iris , choroid , optic nerve ) , or vascular abnormalities affecting the retina ( intraretinal hemorrhages , roth 's spots ) 7 , 8 , 9 , 10 . several processes have been implicated in the ocular manifestations of cml since they epitomize the effects of this disease throughout the entire body system . in the present scenario , such mechanisms include : reduced blood flow , vascular stagnation , retinal capillary dropout , and ischemia . others associate the ocular findings to anemia ; leukostasis ; hyperviscosity syndrome ; leukoembolization ; endothelial lesion , and localized thrombosis secondary to toxic products released by the leukemic cells . angiogenic factors caused by the ischemia resulting in increased serum levels of angiogenic growth factors , comprising elevated levels of vascular endothelial growth factor , fibroblast growth factor 2 , hepatocyte growth factor , and matrix metalloproteinases have all been implicated 11 , 12 , 13 , 14 . in this current case presentation , the high red blood cell distribution width was indicative of anisocytosis common in anemia 15 . furthermore , the increased glycosylated hemoglobin levels and the raised erythrocyte sedimentation rate could be attributed to anemia . however , the declining platelet levels indicated the likelihood of thrombocytopenia in due course . meanwhile , both thrombocytopenia and anemia are almost always present in leukemia 1 . at birth , there is no chronic myeloid leukemia . it occurs when there is damage to the dna of a solitary bone marrow cell . bcrabl gene that causes chronic myeloid leukemia is found in some people , but not in others , though reasons for this observation remain unclear 1 . on the other hand , in a few affected chronic myeloid leukemic persons , contact with extremely elevated measure of radiation have been observed , with marginal increases in risk for cancer patients undergoing radiotherapy . on the contrary , the distinguishing factor for chronic myeloid leukemia is based on the genetic defect of chromosome 22 observed in the blood and marrow cells of patients with leukemia known to be shorter than in healthy people . the ocular complications of leukemia may result directly from metastatic leukemic infiltrates or ensuing from the associated anemia or thrombocytopenia . in addition to the earlier mentioned complications of leukemic retinopathy , exudative retinal detachments and a variety of other retinal defects such as pallor and optic disc edema have been described in literature 3 . there is no direct treatment for leukemic retinopathy , however , chemotherapy , immunotherapy , and radiotherapy are usually employed to manage the underlining systemic cause . chemotherapy that is best suited for intraocular leukemic infiltration , while application of external beam radiation is cut out for optic nerve or orbital lesions 16 . that is , the chronic stable phase , accelerated phase , or the blast crisis . at the chronic phase , bcrabl tyrosine kinase inhibitors ( tkis ) for example , imatinib and interferon alpha , cytotoxic agents for example , hydroxyurea , and allogeneic hematopoietic cell transplantation ( hct ) may be useful . although allogeneic hct remains the sole curative therapy , initial treatment with imatinib has been suggested 16 . in most cases , initial imatinib treatment for chronic phase chronic myeloid leukemia halts the disease progression 17 . the patient 's disease condition responded favorably to the initial treatment with hydroxyurea together with allopurinol . this case highlights the importance of routine eye exams and that clinicians should suspect leukemia in an otherwise healthy patient presenting with ischemic retinopathy .
key clinical messagereported case of leukemic retinopathy mimicking common ischemic retinopathies in a young adult where ophthalmic visit was the first step to the diagnosis of chronic myeloid leukemia . 
 it highlights the importance of routine eye exams and that clinicians should suspect leukemia in an otherwise healthy patient presenting with ischemic retinopathy .