withdrawal of mechanical ventilation in patients beyond hope is often described as  terminal weaning [ 2 , 3 ] , a contradictory word that should be avoided . some icu patients request discontinuation of ventilation themselves [ 12 , 13 ] , but most are unconscious . the decision is usually made by the physician and is based on a lack of correlation between the therapeutic effort and its effect . discontinuation of ventilation should be a process , especially in patients in which it can be predicted that spontaneous respiratory activity will be sustained for a significant period of time , requiring great preparation for adequate treatment of distressing symptoms . few icu scenes evoke greater consternation in relatives than the sight of a loved - one dying in apparent respiratory distress , gasping to catch adequate breath before death . in one study , 33% of intensivists preferred a  slower process of terminal withdrawal of ventilation compared to 13% who preferred  rapid extubation . existing protocols are unsatisfactory due to lack of adequate preparation for treatment of all distressing symptoms [ 15 , 16 ] . post - extubation stridor can give rise to relatives perception that the patient is choking and suffering while dying . care before withdrawal of mechanical ventilation should include : anticipation of pain , dyspnea associated respiratory distress ( dard ) , and terminal restlessness and treatment with adequate administration of opioids and sedatives.treatment of distressing symptoms when they occur despite anticipation.prevention of distressing symptoms such as excessive broncho - pulmonary secretion , death rattle , and post - extubation stridor by means of timely withdrawal of the administration of parenteral fluids , pharmacological treatment of iatrogenic overhydration , and administration of methylprednisolone and anticholinergic agents . anticipation of pain , dyspnea associated respiratory distress ( dard ) , and terminal restlessness and treatment with adequate administration of opioids and sedatives . death rattle , and post - extubation stridor by means of timely withdrawal of the administration of parenteral fluids , pharmacological treatment of iatrogenic overhydration , and administration of methylprednisolone and anticholinergic agents . here administration of opioids , sufficient to counteract pain and/or dard should be established before ventilator withdrawal . since many patients already receive benzodiazepines / opioids before the decision to withdraw treatment , the strategy is based on the existing dose and the prediction of the degree of dard after withdrawal . there is always the risk of under - medicating for pain , based on the assumption that  no - pain is associated with neuromuscular blockade during therapeutic ventilation [ 18 , 19 ] . lying in bed , sedated and with severe organ failure , can cause severe pain in muscles and ligaments , especially in elderly patients . this is the main reason for the administration of opioids for pain in end - of - life care on the icu . opioids are inadequate for sedation because they simply do not induce and maintain sleep , but can induce hallucinations , delirium , and restlessness . one of the reasons to sedate a terminal patient is to relieve terminal stress . organism experiences stress due to organ and systemic failure , leading to irreversible destruction of homeostasis and physical death . an increase in endogenous cortisol is presumed to be a protective reflex against these fatal threats . it was hypothesized that if the extent of the terminal stress reaction was high , high - dose morphine administration would suppress a rise in cortisol levels . however , results indicate that cortisol levels are not suppressed by high - dose morphine . thus the only valid reason for morphine administration is the relief from ( suspected ) pain or the prevention and treatment of dard , which is an observable corollary to subjective dyspnea . for patients and relatives , the sensation of breathlessness is one of the most terrifying symptoms during the dying process . ventilatory insufficiency and failure at the end of life results from a number of causes including reduced respiratory neuromuscular capacity , increased load by airway obstruction , diminished lung and chest wall compliance , and suppression of the cerebral ventilatory drive in response to high co2 levels . several intercurrent stresses such as anxiety , fever , bronchoconstriction , or stridor may increase fatigue by further increasing drive , effort , and load . augmented drive by increase in ventilatory effort can result in fatigue , which is clinically significant as shallow breathing occurs , leading to death . morphine reduces the work load of breathing , thereby protecting against premature death from fatigue . several studies have shown , however , that it does not effect survival in palliative [ 2830 ] and icu patients [ 2 , 26 , 3133 ] . doses exceeding the required amount necessary to achieve the desired effect of symptom relief should not be used . much attention is given to physicians intentions , but distinguishing between intent to provide palliative comfort or to hasten death is an impossible task . indirect or hidden intentions can not be completely determined . the administered dose and choice of medication in the individual patient , rather than intent , should be the determinant as to whether the physician is acting in accordance with normal standards . the often - mentioned risk of  serious respiratory depression is very rare [ 21 , 34 ] . among 1,524 post - operative patients treated with systemic or neuraxial morphine , a respiratory rate of less than 10 breaths respiratory depression has no clear definition , but in most cases it refers to low respiratory rate ( < 10 breaths / min ) , but are of no concern to dying patients , or at times , even desired . death of an icu patient is usually related to fatigue and dysfunction in multiple organs after withdrawal of ventilatory support and is not due to the administration of opioids . fentanyl is a potent analgesic , but should not be used for the prevention or treatment of dard because it can increase muscle tone , leading to chest rigidity . this can induce breathlessness instead of treating it , especially in cachectic patients with weak muscles . we recommend that morphine be started in order to prevent dard , and that fentanyl be continued for pain , if that drug is already being used . morphine could be started in patients with no or low tolerance , as an intravenous dose of 0.1 mg / kg . the pharmacokinetics of intravenous morphine show a peak effect within 30 min and this effect generally lasts for 12 h . palliative sedation is defined as deliberately inducing and maintaining deep sleep for the relief of intractable physical and mental symptoms in the last hours or days of life . in the icu , icu patients , particularly those requiring mechanical ventilation , usually are already sedated such that they can tolerate ventilation and icu - associated noxious stimuli . one of the goals of sedation before and after withdrawal of ventilation is anxiolysis . in icu patients who are dying following withdrawal of ventilation decreased consciousness is a means of achieving symptom relief in patients who are suspected to be dying or whose relatives are witnessing distressing symptoms . seizures , tremors , confusion , anxiety , agitation , and hallucinations can also occur after benzodiazepine withdrawal . this is one of the reasons sedation should never be stopped at the end of life . there is also some evidence suggesting that sedatives , especially lorazepam , are independently associated with the development of delirium . for this reason , we avoid the use of lorazepam as a sedative for symptom control . in some situations , midazolam can be effective when given as adjunct therapy to morphine in order to alleviate dyspnea . there is no evidence that the use of benzodiazepines to treat discomfort after withdrawal of mechanical ventilation hastens death in palliative   or icu patients [ 26 , 31 , 33 ] . midazolam has a rapid onset of action and is easily titrated . in patients with prolonged mechanical ventilation , sedation is problematic because tolerance can be an especially difficult problem in the palliative phase . propofol also has an antiemetic effect , but can be associated with severe myalgia and also can not be given subcutaneously , which could be a problem in some cases.fig . some physicians choose to continue ( or initiate ) neuromuscular blocking agents after withdrawal of ventilation , while others believe that this constitutes deliberate termination of life and is therefore unethical . one earlier study reports continuation of neuromuscular blocking in 9% of 33 patients . in end - of - life care , in almost all patients , comfort can be achieved by adequate dosing of opioids and benzodiazepines or barbiturates without the use of neuromuscular blocking agents , which can and should be reversed within a short period . neuromuscular blocking agents produce only the appearance of comfort   and deliberately terminate life as effect of the iatrogenic neuromuscular blockage in the absence of mechanical ventilation in patients . the agents are often continued or administered for prevention of gasping during the dying process . the half - life of these agents can often be hours and is frequently longer in patients with organ failure . we believe there is no place for neuromuscular blocking agents in the treatment of dying patients after withdrawal of ventilation . it is only in patients who have received the agents in large doses , where neuromuscular function can only be partially restored due to organ failure and extreme fatigue , that an ethical challenge exists . restoration of neuromuscular function can delay the actual withdrawal of mechanical ventilation beyond a point that is ethically defendable , producing more harm than benefit . these patients will not survive after withdrawal of ventilation and will die within minutes to hours , even without the influence of neuromuscular paralysis . the activity of any residual neuromuscular blocking agents can then not be seen as deliberate termination of life . excessive broncho - pulmonary secretion is common in icu patients after withdrawal of prolonged ventilation and can give rise to the development of a death rattle , which is often distressing for relatives to witness . in icu patients , iatrogenic overhydration and prolonged mechanical ventilation withdrawal of mechanical ventilation should always be preceded by withdrawal of all artificial hydration and feeding . furosemide should be given in cases of iatrogenic overhydration to reduce the risk of excessive broncho - pulmonary secretion and death rattle and to prevent airway obstruction and bronchospasm [ 43 , 44 ] . the noise produced by oscillatory movements of secretions in the oropharynx , hypopharynx , and trachea in terminal patients is described as a  death rattle. dying patients are usually too weak to expectorate or swallow the migrating secretions . sputum usually only accumulates in these areas if there is significant impairment of the cough reflex , as in coma or near death . death rattle is commonly reported in patients with neurological and pulmonary conditions during the last 48 h of life , with a prevalence of 4050% . the presence of a death rattle precedes death within 48 h in almost 75% of patients . most patients appear to be unaware of their rattling respiration due to altered consciousness , and as long as they do not suffer , there is no ethical demand to treat it from the perspective of the patient . the primary aim of preventing or treating the noisy breathing is to reduce the distress of relatives of the patients and caregivers . we recommend administration of 20 mg butylscopolamine or 0.4 mg hyoscine hydrobromide 30 min , before extubation to prevent a death rattle . the decision to remove the endotracheal tube should be a secondary decision following discontinuation of ventilation . extubation in the face of death ( often called  terminal extubation ) is the end of curative interventions for life support and symbolizes the start of passage to the end of life . post - extubation stridor is a potential source of distress , especially for the relatives and caregivers . multi - center studies in europe show that extubation preceding death is the least - used treatment , used only in 69% of cases , during discontinuation of ventilation [ 47 , 48 ] . two - thirds of french caregivers felt that extubation should never be considered because it might worsen distress and may have a causal association with death . .   stated that the negative association with extubation stems from the fact that the family may interpret the ensuing noisy respiration or labored breaths as discomfort . they recommend nasal oxygen therapy immediately after extubation and in the case of dyspnea , corticosteroid treatment with a nebulizer . increased sedation and analgesia were given in the case of discomfort ( stridor and asphyxia ) and scopolamine was given in accordance with the amount of respiratory secretions . we recommend non - removal of the endotracheal tube only in exceptional cases because we believe post - extubation stridor and death rattle can be preempted by administering an intravenous injection of a single ( or up to 4/day ) dose of 100 mg of methylprednisolone at least 6 h before extubation . studies found that after a single dose of 100 mg of methylprednisolone , 88% of the patients showed no stridor and 93% showed no stridor after four doses . stridor is the iatrogenic result of endotracheal intubation , which should be prevented and treated when it is distressing for the patient or their relatives . gasping , however , is something that can not be treated and in contrast with post - extubation stridor , is a normal sign of dying . natural sedative at the end of life . for this reason we do object to routine administration of oxygen after extubation . before mechanical ventilation is withdrawn , the icu staff should discuss with the relatives of the patient the intended withdrawal procedure , prepare for distressing symptoms , and the expected chance of survival . the perceptions the relatives have regarding suffering and distress of the patient are important determinants for palliative care after withdrawal of life support . explanation of the possible symptoms and of measures to counteract those symptoms may allow them to rest easier and reduce anxiety . some will even survive the icu . in our experience , most often , this concerns patients with severe cerebral catastrophes , but with intact brainstem and other organ functions . physicians should be aware of this when informing the relatives about prognosis of survival . for relatives , it is paramount that they see that their loved one die without significant distress and that dying should be as natural as can be . for this reason , we recommend a two - phase , 6-h period for the process of withdrawal of mechanical ventilation , taking the aforementioned aspects into consideration ( fig .  1 ) . in the first phase , lasting from 6 h to 30 min before actual withdrawal of mechanical ventilation and removal of the endotracheal tube , the focus is on sedation , analgesia , prevention of dard , post - extubation stridor , and excessive broncho - pulmonary secretions as the result of overhydration . in the second phase , 30 min before actual withdrawal of mechanical ventilation and removal of the endotracheal tube , the focus is on prevention of death rattle by means of medication . when this is followed , most patients will die without significant distress and  naturally without tubes and technology around the bed . the actual phase of discontinuation of mechanical ventilation can be very short , but thoughtful anticipation of distressing symptoms takes more time . given that the patient has serious respiratory or ventilatory insufficiency , multiple organ failure , extremely diseased lungs , or severe neurological dysfunction , withdrawal of mechanical ventilation and subsequent removal of an endotracheal tube often induces or hastens death . these actions do not kill the patient , but allow the patient s disease to complete its natural course . there is an ethical mandate to both anticipate and treat ( iatrogenic ) induced symptoms such as pain , dard , anxiety , delirium , post - extubation stridor , and excessive broncho - pulmonary secretions resulting from overhydration . this makes the process of withdrawal of mechanical ventilation in icu patients a thoughtful process , taking palliative actions instead of fast terminal actions .
backgrounda considerable number of patients admitted to the intensive care unit ( icu ) die following withdrawal of mechanical ventilation . 
 after discontinuation of ventilation without proper preparation , excessive respiratory secretion is common , resulting in a  death rattle. post - extubation stridor can give rise to the relatives perception that the patient is choking and suffering . 
 existing protocols lack adequate anticipatory preparation to respond to all distressing symptoms.methodswe analyzed existing treatment strategies in distressing symptoms after discontinuation of mechanical ventilation.conclusionthe actual period of discontinuation of mechanical ventilation can be very short , but thoughtful anticipation of distressing symptoms takes time . 
 there is an ethical responsibility to anticipate and treat ( iatrogenic ) symptoms such as pain , dyspnea - associated respiratory distress , anxiety , delirium , post - extubation stridor , and excessive broncho - pulmonary secretions . 
 this makes withdrawal of mechanical ventilation in icu patients a thoughtful process , taking palliative actions instead of fast terminal actions . 
 we developed a flowchart covering all possible distressing symptoms that can occur after withdrawal of mechanical ventilation and extubation . 
 we recommend a two - phase process . 
 six hours before extubation , enteral feeding should be stopped and parenteral fluids reduced , overhydrated patients should be dehydrated with furosemide , administration of sedatives ( for distress ) and opioids ( for pain and/or dyspnea ) should be continued or started and methylprednisolone should be given in anticipation of stridor after extubation . 
 thirty minutes before extubation , butylscopolamine should be given and methylprednisolone repeated . 
 after this the patient should be extubated to secure a dying process as natural as possible with the lowest burden due to distress .