a 65-year - old woman was scheduled to undergo a left lobe hepatectomy due to a hepatocellular carcinoma . she had no medical problems with the only exception being liver cirrhosis ( child - pugh class a ) due to chronic hepatitis b. after administering intravenous glycoppyrolate 0.2 mg as premedication , general anesthesia was induced with propofol 100 mg , rocuronium 50 mg and remifentanil 40 g , and maintained with sevoflurane ( 1 - 2.5% ) , remifentanil ( 0.1 - 0.25 g / kg / min ) and rocuronium ( 5 - 10 g / kg / min ) . she was intubated and ventilated mechanically using an anesthesia machine , and monitored continuously by electrocardiography ( ekg ) , arterial blood pressure , central venous pressure and spo2 . one hour after starting the hepatectomy with cusa , there was a sudden decrease in arterial blood pressure ( systolic blood pressure < 40 mmhg ) , end - tidal carbon dioxide ( < 26 mmhg ) and spo2 ( < 50% ) . she also showed tachycardia ( 110 - 135 beats / min ) and a st elevation on the ekg . upon resuscitation with the rapid intravenous administration of colloid and catecholamines ( intravenous epinephrine 1 mg , infusion of norepinephrine ) , intraoperative ultrasonography revealed massive air emboli in both her left and right heart ( fig . arterial blood gas analysis ( abga ) showed the following : ph ( 7.278 ) , pco2 ( 51.3 mmhg ) , po2 ( 84.6 mmhg ) hco3 ( 24.2 mmhg ) , sao2 ( 94.4% ) on fio2 ( 0.5 ) . from 10 minutes after catecholamine administration , her systolic blood pressure and heart rate were maintained at approximately 90 mmhg and 110 beats / min . her central venous pressure was approximately 2 mmhg , which is similar to that before the occurrence of vae . abga at 30 minutes after the occurrence of this episode revealed the following : ph ( 7.338 ) , pco2 ( 44.3 mmhg ) , po2 ( 234.0 mmhg ) , hco3 ( 24.0 mmhg ) , sao2 ( 99.6% ) on fio2 ( 1.0 ) . norepinephrine infusion ( 0.2 - 0.3 g / kg / min ) and fluid resuscitation was continued ( colloid 1000 ml and crystalloid 500 ml was infused ) until the air in her heart had disappeared . the air emboli in her left heart disappeared 70 min later , even though an attempt was made to aspirate the air using an internal jugular venous catheter . the hepatectomy was restarted and completed after confirming the disappearance of air emboli from her heart by intraoperative ultrasonography . from the occurrence of vae to the end of surgery , her systolic pressure was maintained at approximately 90 mmhg despite the norepinephrine infusion ( 0.2 - 0.3 g / min / kg ) . during the operation ( total anesthesia time : 5 hr ) the total urinary output and blood loss was 220 ml and 800 ml , respectively . after surgery , in the intensive care unit , she was still intubated and ventilated mechanically . her systolic pressure was still maintained at approximately 90 mmhg despite the norepinephrine infusion ( 0.2 - 0.3 g / min / kg ) . her postoperative laboratory findings revealed an abnormal pt / ptt ( 25.5/51.8 sec ) , fibrinogen ( 96 mg / dl ) , d - dimer ( 6,519 ng / ml ) , antithrombin iii ( 19% ) , ck - mb ( 40.74 ng / ml ) and troponin - t ( 1.880 ng / ml ) , and the postoperative ekg showed a st elevation in ii , iii and avf . at postoperative day ( pod ) 1 , her ekg findings recovered normally and the trans - thoracic echocardiogram to evaluate her cardiac function showed unremarkable findings and did not reveal the existence of patent foramen ovale ( pfo ) . her vital signs were stable and the norepinephrine infusion was tapered out . however , at pod 5 , her mental status had not changed . 2 ) . at pod 11 , despite the unchanged mental status , she was weaned to spontaneous ventilation with cpap mode and extubated . from pod 15 , finally , panperitonitis was confirmed by the identification of gram ( + ) cocci on the peritoneal culture . at pod 31 , she expired due to a cardiac arrest caused by septic shock . the vae , pae and multiple cerebral infarctions that occurred during a hepatectomy using cusa are presented . previously , koo et al .   reported that vae occurs frequently and massively during a hepatectomy using cusa. although it was not believed to be clinically serious , previous studies strongly suggest that cusa related - pae can develop and cause serious morbidity and mortality . there is always the possibility that vae can cause a pulmonary embolism and cardiopulmonary collapse . furthermore , a paradoxical air embolism can cause major cerebral or coronary morbidity if there is an av shunt or massive air emboli in the patient . a patent foramen ovale ( pfo ) serving as an av shunt is present in approximately 25% of adults . although the precise pressure needed to open a pfo is not known , a clinical investigation showed that pae occurs only in the context of major air embolic events , suggesting that significant increases in pressure in the right side of the heart are important predisposing factors for the occurrence of pae . in addition , air can occasionally traverse the pulmonary vascular bed to reach the systemic circulation . transpulmonary passage is more likely to occur when large volumes of air are presented to the pulmonary vascular filter . it was previously reported that 15 - 45% of patients with liver cirrhosis have pulmonary abnormalities , including an intrapulmonary shunt caused by pulmonary vascular dilation and arteriovenous communication . therefore , paradoxical emboli can occur during an air embolism even if there are no intracardiac abnormalities present in patients with hepatic cirrhosis , such as pfo . in our case , pfo could not be identified . however , the large entrained air volume may increase the pressure of the right side of the heart , which may open a tiny pfo . in addition , air may enter the left side of the heart through transpulmonary passage . although many studies reported that a hepatectomy using an ultrasonic aspirator is safe and simple [ 12 - 14 ] , there is evidence suggesting that severe vae and pae can occur when using cusa. patients at risk of vae or pae should be monitored carefully for the immediate detection of cardiopulmonary collapse ( continuous arterial pressure , spo2 , end tidal co2 ) and cvp catheterization should be performed to aspirate the air in the right atrium . in particular , it is important that patients with limited cardiopulmonary reserve be monitored for the presence of vae ( the combination of precordial doppler and expired co2 monitoring , transesophageal echocardiography ) . in the present case , the omission of nitrous oxide , central venous catheterization , aspiration of entrained air and saline soaking of the surgical field were performed as recommended . vae was not diagnosed earlier because there were no significant signs until the massive vae ( systolic bp < 40 mmhg , sao2 < 50% ) had developed . this case highlights the need for anesthetists and surgeons to be constantly aware of the possibility of cusa related - massive vae and pae . in addition , cusa should be applied for the minimum time possible and be practiced carefully . in addition , precautions should be taken to treat harmful vae , particularly in those patients with liver cirrhosis . furthermore , a brain ischemic injury should be the initial concern if pae is confirmed .
a venous air embolism and paradoxical air embolism ( pae ) are serious complications in patients undergoing a hepatectomy . 
 we report a case of pae and cerebral infarctions in a patient undergoing a hepatic resection using a cavitron ultrasonic surgical aspirator ( cusa ) . 
 a 65-year - old woman underwent a left lobe hepatectomy . during the middle phase of the liver resection with cusa 
 , there was a sudden decrease in arterial blood pressure , end - tidal carbon dioxide and spo2 . with resuscitation , 
 intraoperative ultrasonography revealed massive air emboli in both her left and right heart , which lasted for 40 min . 
 the hepatectomy was completed after the disappearance of the air emboli from her heart . 
 after surgery , her mental status was stuporous . 
 the brain ct and mri revealed multiple acute cerebral infarctions . 
 finally , she died from septic shock . 
 this case highlights the need for anesthetists and surgeons to be aware of the potential for cusa-related massive pae .