this work was supported by the cancerbiome project ( european research council project reference 268985 ) .
inverse gene expression profiling was recently shown to help drug repositioning . 
 we showed that this approach works best for cancer and predicted novel drug candidates that may reduce metastasis in colorectal cancer . 
 antimetastatic activity of our predicted candidate , citalopram , was validated in an orthotopic mouse model of metastatic colorectal cancer .