the fibro - osseous lesions of the maxillofacial bones represent a diverse group of pathologic conditions . though , there is a substantial overlap of the histopathologic findings in the subclassification of these lesions , their management varies depending upon the actual disease process . regardless of the type , they demonstrate replacement of normal bone by the fibrous connective tissue with admixture of mineralized product , including osteoid , mature bone and/or cementum - like calcifications . this group includes developmental , reactive or dysplastic lesions as well as neoplasms [ table 1 ] . classification of benign fibro - osseous lesions of the craniofacial complex clinically , they may vary from cosmetic or functional disturbances to completely asymptomatic lesions recognized on routine radiographs . radiographically , they may vary from solitary to multifocal or multiquadrant involvement ; ill - defined to well - demarcated ; completely radiolucent to mixed radiolucent radio - opaque to radio - opaque or ground glass appearance ; monostotic ( involving one bone ) to polyostotic ( involving more than one bone ) and may or may not be associated with tooth - bearing region ( or root apices ) . grossly , the lesions may vary from smooth to gritty or may have a sandpaper- like appearance . diagnosis of a specific lesion should only be made on the basis of full consideration of clinical , radiological and histopathological features . multiquadrant involvement with mixed radiolucent - radio - opaque lesions is a common finding in florid osseous dysplasias , which have a preponderance of occurring in black females . the prevalence of such lesions in asian males is rare and only one case of florid cemento - osseous dysplasia has been reported in indian male till date . a 26-year - old indian male reported with mild discomfort and tenderness associated with a swelling in mandibular left posterior region since two to three months in molar region . the patient presented with bad oral hygiene with multiple decayed teeth and gave a history of multiple tooth extractions in the maxillary and mandibular regions . orthopantomogram showed a lobular radio - opaque mass associated with apex of impacted left third molar near the angle of the mandible . also , there was a radio - opaque mass with a halo rim in the body of mandible on the same side . on the right side , multiple asymptomatic radio - opaque masses with radiolucent halo were evident in molar region [ figure 1 ] . the mass on the right side did not produce any symptoms and was found only on radiographic examination . radiographic appearance -orthopantomogram showing radio - opaque masses with a radiolucent halo in both the quadrants of mandible . a diffuse radio - opaque mass associated with apex of impacted left third molar incisional biopsy was performed for the diagnostic purpose . grossly , the tissue was creamish yellow to brown , gritty and firm to hard . histopathologically , the outer cortex showed thick linear trabeculae of woven bone and fibrocellular connective tissue stroma . the inner cortex revealed dense mass of woven bone with irregular basophilic reversal lines and scant fibrocellular stroma . in few areas , lacunae were empty . few dysmorphic cementum like masses ( cementoid ) with brush border were also seen within the stroma . the connective tissue consisted of bundles of collagen fibers , fibroblasts and few blood vessels . areas of multinucleated giant cells adjacent to bony and cementoid area were also evident [ figures 24 ] . photomicrgraph showing woven bone with lacunae containing osteocytes in fibrocellular connective tissue ( h&e stain , 100 ) photomicrograph showing the presence of dysmorphic cementum or cementoid ( yellow arrow ) ( h&e stain , 400 ) photomicrograph showing multinucleated giant cells at the periphery of the osteoid ( h&e stain , 400 ) photomicrograph showing the areas of hemorrhage in the section ( h&e stain , 100 ) various lab investigations like complete blood count , random blood glucose levels , serum calcium , serum phosphate and serum parathyroid were carried out and were shown to be within the normal limits . serum total calcium level , serum phosphate level and serum parathyroid level was 10 mg / dl , 3.2 mg / dl and was 25 pg / ml , respectively . thus , to summarize , bilateral mandibular radio - opacities surrounded by a radiolucent rim with evident masses of woven bone and dysmorphic cementum like calcifications were seen . after correlating the clinical , radiographic and histopathological features the lesion was diagnosed as florid cemento - osseous dysplasia . patient was advised for regular follow - ups as these lesions are asymptomatic and does not require resection . a swelling with mild discomfort and tenderness of short duration in the posterior mandible of a 26-year - old male may vary from an infected , inflammatory lesion to the presence of a malignancy invading the surrounding tissues . rarely does it occur as a result of a benign quiescent lesion , which may need not undergo extensive surgical treatment . the clinical differential diagnoses in the present case included infected dental cysts , chronic osteomyelitis , cementoblastoma , osteoblastoma and jaw malignancies due to nerve impingement as osteosarcoma and intraosseous squamous cell carcinoma . radiographically , our case presented with mixed radio - opaque radiolucent lesion and hence , differential diagnosis included complex odontome , cemento - ossifying fibroma , fibrous dysplasia , cementoblastoma , osteoblastoma and cemento - osseous dysplasia . infected dental cysts clinically present as tender swellings of the jaws , hence was also considered . radiographically , the lesion presented as a radio - opaque mass and since cysts appear as radiolucent lesions in jaws with distinct borders this differential was excluded . condensing osteomyelitis can occur at any age though uncommon after third decade and produces swelling . the patient had a history of carious extracted molars in left mandible which lead to consideration of condensing osteitis as a probable diagnosis . but , it is a focal lesion with involvement of the bone surrounding and extending below the apex of the teeth . in contrast our case showed multiple lesions with bilateral jaw involvement without necessary relation to the tooth . complex odontome presents radiographically as irregular calcified material surrounded by a narrow radiolucent rim and may be associated with pain when secondary infection occurrs , but histopathologically shows the presence of enamel , dentin , pulp tissue and cementum . cemento - ossifying fibroma presents radiographically as a solitary spherical or oval shaped mixed radiolucent radio - opaque lesion with well - delineated margins and centrifugal growth pattern , which at a later stage may attain larger size . fibrous dysplasia presents radiographically as fusiform non - demarcated radio - opacity giving typical ground glass appearance . the indistinct margins gradually blend into normal bone but on histopathological examination evenly spaced irregular shaped trabeculae with characteristic chinese letter appearance , stellate osteoblasts with osteoblastic rimming and trabeculae having wide osteoid seams are evident . a characteristic histopathological finding of paget disease is a pattern of irregular basophilic reversal lines mimicking a mosaic ; due to repeated destruction and repair . despite this close histopathologic resemblance in the present case , paget 's disease has been excluded as a diagnosis , as the clinical and radiographic features are contraindicating the same . paget 's disease manifests as a generalized diffuse swelling , affecting the entire mandible after 50 years of age , whereas the clinical presentation of our case is a localized lesion in a 26-year - old male . radiographically , our case depicts multiple round radiopacities surrounded by a halo rim ; on the contrary , paget 's disease shows a mixture of ill - defined radiopacities , bone expansion and radiolucency giving a characteristic cotton wool appearance . cementoblastomas are swellings reported in younger age group with mandibular site predilection and so , it was also taken into consideration . radiographically , they appear as well - circumscribed dense radio - opaque mass surrounded by uniform radiolucent line , attached to the tooth but also showed multiple mixed radio - opaque radiolucent lesions throughout the jaw . osteoblastoma is a benign tumor of the bone , with male predilection in the second decade . it presents with dull , mild pain and mixed radiopaque radiolucent lesion , the feature similar to the present case but , osteoblastoma does not appear as multiple lesions involving the jaws bilaterally as was seen in the present case . osteosarcomas are malignant lesions of the bone and are usually seen in younger age group , with swelling and pain being early features of the neoplasm along with a history of short duration . but the intense radio - opacity and the absence of typical sun - burst appearance and codman 's triangle reduced the probability of a malignant lesion which would show a more diffused radiolucency . intraosseous squamous cell carcinoma was also considered due to its mandibular site , short duration , mild tenderness and male predilection , also it is generally associated with the impacted wisdom tooth . but as it is associated with extensive bone destruction with a radiographic floating tooth appearance . cemento - osseous dysplasias also show mixed radiolucent radiopaque masses associated with tooth bearing regions of the jaws . multiple lesions may be seen in florid cemento - osseous dysplasia involving two to four quadrants . but , florid cemento - osseous dysplasias have a tendency to occur in black females . histopathologically , they show the presence of irregular trabeculae of immature woven bone or osteoid , multinucleated giant cells and also , the presence of dysmorphic cementum or cementoid with basophilic reversal lines . the present case showed histopathological features suggestive of cemento - osseous dysplasia along with multiquadrant involvement with well - defined radio - opaque lesions . thus , it was diagnosed as florid cemento - osseous dysplasia , though the age and sex parameters were not suggestive of this lesion . these lesions are usually asymptomatic , but our patient presented with mild discomfort , which was probably due to mandibular nerve impingement . florid cemento - osseous dysplasias are reactive , non - neoplastic lesions confined to tooth bearing areas of jaws . since they develop in tooth bearing region ( from periodontal ligament ) , their presence is related to unique presence of tooth and periodontium within jaws . gigantiform cementomas  which later came to be known as florid cemento - osseous dysplasia in the second edition of the world health organization ( who ) 's  international histological classification of odontogenic tumors . the use of the term dysplasia refers to abnormal production and disordered development of bone and cementum - like mass / material . waldron in 1985 suggested that these lesions originate from the elements of periodontal ligament ( pdl ) as they appear to develop in intimate relationship with the roots of teeth or in the peri - apical region of edentulous parts of the jaws . reichart suggested a connection with chronic osteomyelitis and proposed an inflammatory origin of this lesion . the cell of origin is accredited to the group of the multipotent stem cells , which reside in the pdl . various trigger factors stimulate the re - entry of these quiescent mesenchymal cells into the cell cycle , which lead to the formation of physiologic or pathologic tissues . in this lesion , the mesenchymal stem cells seem to have lost their ability to maintain their structural and functional morphology and , therefore , produce morphologically imperfect bone or cementum . to elaborate , the mechanism involves localized areas of bone being replaced by fibrous tissue , succeeded by calcified masses , which are laid down in the form of cemental layers and bony trabaculae . as this process continues , both cemental and osseous terms can be used interchangeably as both are derived from same mesenchymal cells that have lost their ability to maintain their structural morphology and thus producing dysplastic bone . florid cemento - osseous dysplasias represents symmetric lesions affecting sextants and sometimes all quadrants may be involved but the predilection for posterior region of mandible is 78% . florid cemento - osseous dysplasia has predilection for black females , which may suggest that this dysplastic process is related to hormonal imbalance that influences bone remodeling during fourth to fifth decade of life . it is more prevalent in blacks ( 78% ) than in whites ( 5% ) and asians ( 4% ) . among asians , indians form 2% . out of the 11 cases reported so far , 10 were females and one was a 14-year- old male with involvement of all the quadrants . pain is not a common finding in florid cemento - osseous dysplasia , only 4 patients ( 38-year - old female , 60-year - old female , 56-year - old female and 41-year - old female ) out of total 11 cases reported in india had pain associated with the lesion [ table 2 ] . florid cemento - osseous dysplasias are benign , non - neoplastic , asymptomatic , self - limiting lesions . however , exposure of the sclerotic masses to the oral cavity may lead to secondary infection , which may be difficult and complicated to manage . since the radiographic and histologic spectrum is similar to other fibro - osseous lesions with a different treatment plan , surgical intervention is not the choice of treatment , as it may result in secondary complications ; hence , patient is kept under observation and frequent follow - ups .
tender swellings of the mandible are majorly due to inflammatory lesions like infected dental cyst , peri - apical abscess or neoplasms like osteoblastomas , cementoblastomas , osteosarcoma and intraosseous squamous cell carcinoma . 
 florid cemento - osseous dysplasia is a subgroup of cemento - osseous dysplasia typically found in middle - aged black women as multiple , non - tender , diffuse , lobulated radio - opacities distributed throughout the maxilla and mandible , which are usually bilaterally symmetrical . 
 histologically , they are composed of proliferating fibrous connective tissue stroma containing foci of cementum , osteoid and bone . 
 florid cemento - osseous dysplasia is rare in indian population and among all cases of florid cemento - osseous dysplasia , almost 97% of the cases reported till date are in females . 
 the present case describes florid cemento - osseous dysplasia in a 26-year - old male who reported with pain in the left mandibular premolar region .