the present study investigated the difference between therapeutic responses of hot and cold temperament patients ( based on traditional persian medicine ) with ulcerative colitis to pomegranate peel extract . seventy - eight patients with moderate ulcerative colitis based on lichtiger colitis activity index ( lcai ) criteria were randomized to receive an aqueous extract of the punica granatum peel ( 6 gram per day ) or placebo for four weeks . they were assessed before and after the intervention in terms of symptoms by lcai scoring system . the results were compared in two therapeutic groups based on the patient s temperament ( cold and hot ) which were diagnosed based on a previously validated questionnaire . therapeutic response was significantly higher in patients with hot temperament compared to patients with cold temperament in the p. granatum group ( 1.910.492 vs. -0.5000.500 , p=0.029 ) . this study showed the importance of considering syndrome differentiation and temperament in interpreting the effect of p. granatum peel extract on ulcerative colitis .
background : the present study investigated the difference between therapeutic responses of hot and cold temperament patients ( based on traditional persian medicine ) with ulcerative colitis to pomegranate peel extract.methods:seventy-eight patients with moderate ulcerative colitis based on lichtiger colitis activity index ( lcai ) criteria were randomized to receive an aqueous extract of the punica granatum peel ( 6 gram per day ) or placebo for four weeks . they were assessed before and after the intervention in terms of symptoms by lcai scoring system . 
 the results were compared in two therapeutic groups based on the patient s temperament ( cold and hot ) which were diagnosed based on a previously validated questionnaire.results:therapeutic response was significantly higher in patients with hot temperament compared to patients with cold temperament in the p. granatum group ( 1.910.492 vs. -0.5000.500 , p=0.029).conclusion : this study showed the importance of considering syndrome differentiation and temperament in interpreting the effect of p. granatum peel extract on ulcerative colitis .