ff and sb analyzed clinical , cytogenetic and molecular data and wrote the manuscript ; mm , lp , vf , lf , vn , am , ap took care of the patient , collected and analyzed clinical data and critically revised the manuscript ; ml critically revised the manuscript .
we report the first case of acute myeloid leukemia ( aml ) with runx1mecom fusion transcripts , showing marked eosinophilia . 
 a 63-year old man admitted in august 2013 , had previously been observed in april 2013 , because of persisting homogeneous splenomegaly and increased ldh , which were initially attributed to both minor -thalassemia and previous acute myocardial infarction . 
 however , based upon the retrospective analysis of clinical features combined with the documentation of both jak2 v617f and c - kit d816v mutations at aml diagnosis , an aggressive leukemic transformation with eosinophilia of a previously unrecognized myeloproliferative neoplasm , rather than the occurrence of de novo aml , may be hypothesized .