foodnet is a collaborative program among the centers for disease control and prevention , 10 state health departments , the us department of agriculture , and the food and drug administration . foodnet conducts active , population - based surveillance for selected laboratory - confirmed enteric infections . in 2010 , clinical laboratories within foodnet were asked to query records for all laboratory - confirmed isolations of cronobacter spp . ( formerly enterobacter sakazakii ) reported from january 1 , 2003 , through december 31 , 2009 , or for as many months in this period as was feasible . participating laboratories were in california , colorado , maryland , minnesota , new mexico , and tennessee . we recorded information on patient age , isolation site , and date ( month and year ) of specimen collection . we conducted descriptive analyses and calculated incidence rates within age groups and overall by using excel ( microsoft corp . , redmond , wa , usa ) and sas version 9.3 ( sas institute , cary , nc , usa ) . for incidence calculations , we estimated the number of persons served by each laboratory by calculating the proportion of isolates of other enteric pathogens ( campylobacter , listeria , salmonella , vibrio , and yersinia spp . and shiga toxin producing escherichia coli ) that each laboratory reported to foodnet , by age group , for each year that the laboratory was surveyed . we applied this proportion to us census data for that age group , year , and foodnet site and summed values from all laboratories to obtain an age - group denominator for 20032009 . we then calculated age - specific incidence rates by dividing the number of cronobacter cases for each age group by the overall age - group denominator and multiplying by 100,000 . similarly , we calculated the overall incidence rate by dividing the total number of cronobacter cases by the sum of the age - group denominators and multiplying by 100,000 . the overall median patient age was 59 years ( range 1 day100 years ) ; by state , median ages ranged from 52 years ( tennessee ) to 71 years ( colorado ) . of the 544 patients , 198 ( 37% ) were > 70 years of age and 22 ( 4% ) were infants < 1 year of age . cronobacter spp . was most frequently isolated from urine ( 221 [ 41% ] isolates ) ; wound , abscess , or surgical site ( 115 [ 21% ] ) ; respiratory tract ( sputum , pharyngeal swab , or tracheal aspirates ) ( 87 [ 16% ] ) ; blood ( 51 [ 9% ] ) ; feces ( 31 [ 6% ] ) ; bile ( 16 [ 3% ] ) ; cerebrospinal fluid ( 5 [ 1% ] ) , and other or unknown sources ( 18 [ 3% ] ) . the highest percentage of invasive infections occurred among infants ( 6 [ 27% ] of 22 ) and children 14 years of age ( 5 [ 22% ] of 23 ) , and isolates from urine predominated among those in most adult age categories ( figure 1 ) . other than a slight increase in the number of isolations in april , no seasonal patterns were detected . foodborne diseases active surveillance network ( foodnet ) , 20032009 . data are based on a sample from laboratories in 6 states ( california , colorado , maryland , minnesota , new mexico , and tennessee ) in the foodnet catchment area and are reported for 535 of 544 patients ( age information missing for 9 patients ) . the overall incidence rate was 0.66 cases per 100,000 population ; rates varied by age , state , and invasiveness . the highest rates occurred among persons > 80 years of age ( 3.93 cases/100,000 population ) , followed by persons 7079 years of age ( 2.11 ) and infants ( 1.81 ) ( figure 2 ) . rates of invasive infection were 0.07 cases per 100,000 population overall and were highest among infants ( 0.49 ) and persons > 80 years of age ( 0.33 ) ( figure 2 , panel a ) . overall incidence rates among infants were highest in minnesota , and rates among persons > 80 years of age were highest in colorado . rates of urinary tract isolation were 0.27 isolates per 100,000 population overall and highest among persons > 80 ( 2.62 ) and 7079 ( 1.22 ) years of age . incidence rates , by age group ( overall and range by site ) in the foodborne diseases active surveillance network ( foodnet ) , 20032009 . incidence rates for invasive isolates by age group ( overall and range by site ) , foodnet , 20032009 . data are based on a sample from laboratories in 6 states ( california , colorado , maryland , minnesota , new mexico , and tennessee ) in the foodnet catchment area and are reported for 535 of 544 patients ( age information missing for 9 patients ) . the rates for infants in our study were similar to those previously estimated for infants in the united states ( 11 ) . the rates of bacteremia that we found among infants and older adults in the united states were higher than those reported in the philippines and the netherlands and similar to those reported in the united kingdom ( 13,14).the higher rates for minnesota might be explained by the reporting requirements in that state ; however , high rates among adults in other states suggest that the geographic variation may be real . although rates were highest among persons at age extremes , we documented isolations for persons in all age groups and from a variety of clinical specimen sources . although infants accounted for only a small percentage of isolates , they also accounted for the highest rate of invasive infections . more than a third of isolates from infants came from the respiratory tract and might represent colonization rather than infection . rates for adults > 80 years of age were higher than rates for any other age group and twice as high as rates for infants ; however , we lack information to distinguish infection from colonization . half of the isolates in our survey came from urine , and these were mainly from older adults . ( 3,15 ) , our data suggest that urine might be a more common site of infection than previously thought . studies are needed to understand the contribution of cronobacter spp . to the prevalence and costs associated with urinary tract infections , which are common in older adults . only a third of laboratories that participate in foodnet provided data for this study , and reporting varied by state and year . our sample might not be representative of the states surveyed or the united states as a whole . because we did not review charts or interview patients , we did not have information on underlying conditions , clinical signs and symptoms , patient sex , or possible exposures . although rates of invasive cronobacter spp . infections among infants in our study approximated earlier estimates , overall rates of isolation of cronobacter spp . from ill persons in the united states were higher than we anticipated , and the very young and very old were disproportionately affected . a substantial proportion of isolates came from the urinary tract , raising questions about risk factors for transmission and clinical manifestations . routine , systematic surveillance and special studies will be essential for understanding these findings , identifying reservoirs of infection and vehicles of transmission , and developing effective prevention and control measures .
during 20032009 , we identified 544 cases of cronobacter spp . 
 infection from 6 us states . 
 the highest percentage of invasive infections occurred among children < 5 years of age ; urine isolates predominated among adults . 
 rates of invasive infections among infants approximate earlier estimates . 
 overall incidence of 0.66 cases/100,000 population was higher than anticipated .