neurofibromatosis type 1 ( nf1 ) , formerly known as von recklinghausen s disease , is an autosomal dominant inherited condition with an incidence of 1:2,5001:3,000 , and a prevalence of 1:4,0001:5,000 . clinical manifestations of nf1 involve multiple systems , including the nervous system , bone , and skin , with patients developing manifestations of hyperpigmentation and neurofibromas . the national institute of health ( nih ) consensus development conference have determined the diagnostic criteria for nf1 , which requires two or more of the following : six or more caf au lait macules ; two or more cutaneous / subcutaneous neurofibromas , or one plexiform neurofibroma ; axillary / groin freckling ; optic glioma ; two or more lisch nodules in the eyes ; bony dysplasia ; and a first - degree relative with nf1 . cutaneous neurofibromas can affect any part of the body and can vary in size , number , and distribution . significant disfigurement can result from the growth of hundreds of cutaneous neurofibromas , leading to social isolation and emotional distress . treatment of cutaneous neurofibromas is predominantly surgical but alternative treatments need to be considered for patients with multiple lesions often in excess of 100 , in whom surgical intervention may not be possible or desirable . the co2 laser has been shown to be effective in treating large numbers of small - to - medium sized neurofibromas with cosmetic outcomes equal to or even better than surgical excision [ 2 , 7 ] . however , evidence for co2 effectiveness , effect of treatment on patient satisfaction , and rate of recurrence post - treatment is scarce . the authors evaluated a series of patients with multiple neurofibromas that were successfully treated using co2 laser treatment under general anesthetic , and assessed patient satisfaction with the treatment and rate of recurrence post - treatment . the authors inclusion criteria included patients who were diagnosed with nf1 , fulfilled the nih consensus development conference nf1 diagnostic criteria , had more than 100 neurofibromas of varying sizes , and were treated with co2 laser treatment over the last 4  years . informed consent was obtained from five patients ( 71% response rate ) for a post - treatment telephone survey . all patients underwent test patches with the co2 laser and were reviewed at 36  months when the results were assessed . the sharplan 40 c silktouch laser ( laser industries ltd . , tel aviv , israel ) was used in its freehand continuous mode ( 1020  w with rapid side - to - side hand movements ) or in scanner settings ( 125  mm hand piece , 714  w , 3  mm spot ) to ablate the small neurofibromas . the incision was then extended as the neurofibroma was held with forceps and the entire dumbbell - shaped lesion was excised using the laser . bleeding was rarely encountered and was easily controlled using the defocused laser beam or vicryl ( johnson & johnson , nj , usa ) . postoperatively , antibacterial ointment ( mupirocin , bactroban ; smithkline beecham corporation , philadelphia , pa , usa ) was applied under hydrocolloid dressings as the laser wounds healed with secondary intention . wounds that were considered large enough for delayed secondary intention healing were sutured with vicryl . all patients were followed up 3 and 6  months later to review the wound , scarring , and cosmetic outcome of treated neurofibroma lesions . five patients completed the post - treatment telephone survey , which was conducted by the same doctor . patients were asked to rate their satisfaction of co2 laser treatment ( score 010 ) and whether they would recommend co2 laser treatment to other patients . retrospective data on co2 laser treatments , follow - up , and recurrence following treatment was obtained . the authors inclusion criteria included patients who were diagnosed with nf1 , fulfilled the nih consensus development conference nf1 diagnostic criteria , had more than 100 neurofibromas of varying sizes , and were treated with co2 laser treatment over the last 4  years . informed consent was obtained from five patients ( 71% response rate ) for a post - treatment telephone survey . all patients underwent test patches with the co2 laser and were reviewed at 36  months when the results were assessed . if satisfactory , patients were then invited for co2 laser treatment under general anesthetic . the sharplan 40 c silktouch laser ( laser industries ltd . , tel aviv , israel ) was used in its freehand continuous mode ( 1020  w with rapid side - to - side hand movements ) or in scanner settings ( 125  mm hand piece , 714  w , 3  mm spot ) to ablate the small neurofibromas . the incision was then extended as the neurofibroma was held with forceps and the entire dumbbell - shaped lesion was excised using the laser . bleeding was rarely encountered and was easily controlled using the defocused laser beam or vicryl ( johnson & johnson , nj , usa ) . postoperatively , antibacterial ointment ( mupirocin , bactroban ; smithkline beecham corporation , philadelphia , pa , usa ) was applied under hydrocolloid dressings as the laser wounds healed with secondary intention . wounds that were considered large enough for delayed secondary intention healing were sutured with vicryl . all patients were followed up 3 and 6  months later to review the wound , scarring , and cosmetic outcome of treated neurofibroma lesions . five patients completed the post - treatment telephone survey , which was conducted by the same doctor . patients were asked to rate their satisfaction of co2 laser treatment ( score 010 ) and whether they would recommend co2 laser treatment to other patients . retrospective data on co2 laser treatments , follow - up , and recurrence following treatment was obtained . all patients had more than 100 neurofibromas of varying sizes . the mean age of patients was 45.2 ( age range 3656 ) with a male / female ratio of 3:2 . four patients had truncal neurofibromas and one had treatment for neurofibromas on facial , neck , and upper limb skin . the mean follow - up period was 14.4  months ( range 624  months ) . three patients ( 60% ) had no lesional recurrence 2  years post - co2 laser treatment . two patients ( 40% ) had recurrence of a few of the treated lesions ( 10% of treated lesions per patient ) . preoperative and postoperative photos are shown in figs .  1 , 2 and 3 . the wounds were erythematous for approximately 36  months , and matured into hypopigmented and sometimes atrophic scars . there were no significant complications . all five patients reported that treatment - induced scarring was cosmetically preferable to neurofibroma lesions . 1patient 1 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laserfig . 2patient 2 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laserfig . 3patient 3 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laser patient 1 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laser patient 2 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laser patient 3 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laser the mean patient satisfaction score was 9.2 out of 10 ( range 810 ) . all five patients ( 100% ) commented that they would recommend co2 laser treatment to other patients with neurofibromas . all patients had more than 100 neurofibromas of varying sizes . the mean age of patients was 45.2 ( age range 3656 ) with a male / female ratio of 3:2 . four patients had truncal neurofibromas and one had treatment for neurofibromas on facial , neck , and upper limb skin . the mean follow - up period was 14.4  months ( range 624  months ) . three patients ( 60% ) had no lesional recurrence 2  years post - co2 laser treatment . two patients ( 40% ) had recurrence of a few of the treated lesions ( 10% of treated lesions per patient ) . preoperative and postoperative photos are shown in figs .  1 , 2 and 3 . the wounds were erythematous for approximately 36  months , and matured into hypopigmented and sometimes atrophic scars . there were no significant complications . all five patients reported that treatment - induced scarring was cosmetically preferable to neurofibroma lesions . 1patient 1 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laserfig . 2patient 2 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laserfig . 3patient 3 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laser patient 1 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laser patient 2 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laser patient 3 . before ( a ) and 6  months after ( b ) excision of neurofibromas with the co2 laser all five patients ( 100% ) commented that they would recommend co2 laser treatment to other patients with neurofibromas . surgical excision is the standard procedure for removal of lesions , with advantages of a neat linear scar and a specimen for histology . co2 laser treatment is suitable for removing large numbers of neurofibromas in a short time with good cosmetic outcomes and a low complication rate [ 2 , 8 ] . the current study confirmed that co2 laser treatment under general anesthetic for hundreds of small - to - medium - sized cutaneous neurofibromas has a high patient satisfaction and recommendation rate . previous studies have demonstrated that co2 laser treatment improved patients self - confidence , social , and sexual lives [ 2 , 8 ] . reported that the depigmented scars from laser treatment were more acceptable to patients than scars from surgical excision , a finding was echoed by patients in the current study . previously reported physical and psychological benefits following co2 laser are summarized in table  1 [ 2 , 8 ] . patients in the current study reported high satisfaction levels , suggesting that co2 laser treatment can potentially improve patients psychological well-being.table  1comparison of results from the current study with the published literaturestudiesmain findingsmoreno et al . 82% reported good level of improvement in symptoms ( e.g. , pain , pruritus ) , and social activity73% reported good level of improvement in sexual activity100% reported good level of improvement from feeling of despair73% satisfaction and recommendation ratealgermissen et al . most reported an increase in self - confidence and acceptance from the social surroundingchiang et al . ( this study)9.2 mean satisfaction score ( score out of 10)100% recommendation rate comparison of results from the current study with the published literature to the authors knowledge , there have been no previous reports of recurrences following co2 laser treatment . the current study showed that 40% of patients had regrowth of some lesions within 2  years , but these represented 10% of treated lesions per patient . patient skin type and skin color was not documented at the start of treatment and , hence , the authors were unable to assess the potential relationship between post - treatment pigmentary changes and skin color . there may also be a potential bias with the use of a telephone survey in assessing patient satisfaction levels . in addition , the short follow - up post - treatment in the current study may not allow the authors to fully assess the recurrence of neurofibroma lesions . future studies with a larger number of patients , longer follow - up period , and studies that offer comparative data of co2 laser treatment with surgical treatment of cutaneous neurofibromas are needed for further clarification of the effectiveness of co2 laser treatment for cutaneous neurofibromas . the authors found that co2 laser treatment for cutaneous neurofibromas is associated with a low recurrence rate , achieves a high level of patient satisfaction , and potentially offers a useful alternative to surgical excision , particularly in patients with multiple lesions . this article is distributed under the terms of the creative commons attribution noncommercial license which permits any noncommercial use , distribution , and reproduction in any medium , provided the original author(s ) and source are credited .
introductionneurofibromatosis type 1 ( nf1 ) is an autosomal dominant disorder , with multisystem involvement , including cutaneous manifestations of hyperpigmentation and neurofibromas . 
 multiple cutaneous lesions are often disfiguring and lead to emotional distress and social isolation . 
 treatment of nf1 is predominantly surgical but alternative treatments should be considered for patients with large numbers of lesions as cold steel excision of multiple lesions can be cumbersome and may not be practical . 
 the authors report a series of patients with multiple neurofibromas successfully treated using a co2 laser.methodsdata on co2 laser treatments , follow - up , and recurrence following treatment was collected retrospectively . 
 a post - treatment telephone survey was carried out to assess patient satisfaction using a standardized set of questions and a scoring tool.resultsfive of seven patients who underwent co2 laser treatment of their multiple neurofibromas responded to the post - treatment survey . 
 all five patients ( age range 3656  years , mean age 45.2  years , three men : two women ) had multiple variable - sized neurofibromas . 
 the mean number of lesions per patient was 114 ( range 20200 lesions ) . 
 the mean number of treatment sessions was 2.2 ( range 14 sessions ) and mean follow - up was 14.4  months ( range 624  months ) . 
 three patients ( 60% ) reported no recurrence up to 2  years post - laser treatment . 
 two patients ( 40% ) had recurrences of a few lesions ( 10% of treated lesions per patient ) . 
 the mean patient satisfaction score was 9.2 out of 10 ( range 810 ) . 
 all patients mentioned that they would recommend co2 laser treatment to others with multiple neurofibromas . 
 hypopigmentation or depigmentation at treatment sites were the only reported adverse effects.conclusionbased on current results , the authors feel that co2 laser treatment achieves a high level of patient satisfaction with a low recurrence of treated lesions .