reconstruction of the mandible is to restore the shape and function of the face , the continuity of the mandible and the muscular attachment . principles of reconstruction have evolved dramatically over the recent years with the aim of improving the patient s quality of life . investigators have reported various approaches for reconstruction of the mandible and so far , autogenous bone grafting is considered as the golden standard . while microvascular flaps have been successfully used to correct defects with significant soft tissue deficiencies . several authorshave studied the use of frebone grafts harvested mostly from the iliac for delayed or immediate reconstruction of the mandible . spontaneous regeneration of the mandible on the other hand , has been rarely stated in previous studies [ 47 ] . our review of literature showed only one report of spontaneous regeneration of the whole mandible . the present study presents a rare case of spontaneous regeneration of the hemimandible with a well - shaped condyle and coronoid in a 19-year - old patient following hemimandibulectomy for the treatment of an extensive odontogenickeratocyst . a 19-year - old male subject with a one year history of painless swelling in the posterior region of the left mandible was referred to the department of oral and maxillofacial surgery , shahidbeheshti university of medicalsciences on april 18 , 2007 . intraoral examination revealed a minimal expansion of the body and ramus of the mandible extending from the left second premolar to the anterior border of the ramus . the overlying mucosa was normal , whereas the first and second molar teeth were moderately mobile . radiographic examination demonstrated an extensive multilucular radiolucency extending from the left second premolar to the left sub - condylar region ( fig 1 ) . in computed tomography views , perforations of the lingual side of the mandible intra - oral incisional biopsy confirmed the diagnosis of odontogenickeratocyst . due to the wide extension of the lesion , intra - oral hemimandibulectomy was selected as the treatment of choice for the patient . sulcular incision extending from the left first premolar to the ascending ramus parallel to the external oblique ridge was made and periosteum was gently elevated from both buccal and lingual sides . the left hemimandible was then disarticulated from the glenoid fossa ( fig 2a , b ) . a well shaped reconstruction plate that simulated the curvature of the mandible was used to preserve the surgical bed and improve the facial contour ( fig 2c , d ) . three layer tension free closure of the wound was obtained after rigid fixation of the reconstruction plate . one year radiographic follow - up of the patient revealed spontaneous healing of the mandible with a well shaped condyle and coronoid process ( fig 3a ) . ct scan views also confirmed the evidence of denovo mandibular regeneration ( fig 3b , c ) . during removal of the reconstruction plate the obtained specimen was embedded for 24 hours in 10% formalin for fixation and underwent a 7-day treatment with 10% formic acid for decalcification . sections were stained with hematoxylin and eosin which appeared to be consolidated , well - shaped trabecular bone . the bone marrow space was also filled with dense fibrous connective tissue ( fig 4 ) . bone tissue is believed to have the capacity to regenerate spontaneously following injury . however , literature reports rare cases of this event following resection of a part or the whole of the mandible [ 49 ] . although the exact mechanism that induces spontaneous bone regeneration is not fully understood , several factors including the patient s age , preservation of the periosteum , infection , post operation immobilization   and genetic behavior   have been suggested to influence this process . adekeye et al reported a spontaneous regeneration of the mandible affected by an infected ameloblastoma seven months after resection . complete regeneration of a mandible was also reported in a case with a history of an infected lesion 3 years prior to a complete mandibulectomy . however , in the case described in this study , there were no signs of infection either preoperatively or during the healing period . age is believed to be an important influential factor on the process of spontaneous bone regeneration . based on our review of literature , most patients with a report of this event in their records were younger than 15 years old [ 4,68 ] , with the exception of two 27-year - old male subjects and a 32-year - old woman . it is suggested that the cellular activities that influence bone regeneration are higher in younger patients . in the case presented in this study too , age may have played an important role . nineteen years of age ; however , seems to be a median age compared with the reported cases of spontaneous mandibular regeneration . the role of periosteum as an important structure in bone healing and bone grafting is well recognized [ 810 ] and therefore , preservation of periosteum might have a central role in bone regeneration procedures . it is also reported that periosteum has an important function in spontaneous bone regeneration [ 46,911 ] . rugerrio and donoff reported a case of mandibular spontaneous regeneration after irradiation , concluding that even an irradiated periosteum has some osteogenic potential although to a lesser degree than non - irradiated tissue . while most of the reported cases with spontaneous regeneration of the mandible had gone through resection of the mandible by an extra - oral incision approach , our surgical method was the same as oganlewe et al , who used an intraoral approach for total mandibulectomy . authors believed that an intraoral incision in this case might preserve the periosteum better than extra oral approaches . this structure is believed to be well tolerated by the human tissue and seems to act as a favorable guide for bone regeneration . reviewed literature for this case report revealed no histological analysis of the spontaneously regenerated mandible . in this case , authors had the chance to harvest newly formed bone during removal of the plate . the following microscopic examination demonstrated a dense network of trabecular bone with fibrous connective tissue in bone marrow spaces , supporting the presence of a reactive phenomenon . it seems that a delicate surgical removal of a pathologic lesion with preservation of periosteum in young patients alongside the use of an appropriate space maintainer device may lead to spontaneous bone regeneration . the present case report describes spontaneous regeneration of a hemi - mandible with well shaped condyle and coronoid after resecting a pathologic lesion of the mandible in a young man . this observation might demonstrate that while most in vitro tissue engineering methods or in situ regeneration approaches fail to reconstruct a functional bone , human body itself , has a unique capacity in bone regeneration and tissue engineering researchers can count on the regenerative potential of the body more than before .
mandibular defects may result from many conditions such as trauma , inflammatory diseases and tumors . 
 there are rare cases reported in the literature that have demonstrated spontaneous bone regeneration after resection of the mandible . 
 several factors such as age , preservation of the periosteum and genetics seem to influence spontaneous bone regeneration capacity in individuals . 
 evaluation of these factors may lead to a better understanding of the mechanism of spontaneous bone regeneration and also help to create new methods for bone reconstruction . 
 the purpose of this article was to describe the spontaneous regeneration of the hemi - mandible with a well shaped condyle and coronoid after resecting a mandibular pathologic lesion in a young man .