no funding was received for preparing this work ; open access was funded by boston scientific corporation .
pre - clinical studies of renal denervation would suggest that the extent of renal nerve injury correlates with outcomes . 
 the  completeness  of renal nerve injury following renal denervation correlates with treatment - based variables such as the depth of ablation , the number of ablations along the length of the artery , and the number of renal arteries successfully ablated . 
 renal denervation techniques targeting only main renal arteries may lead to suboptimal results in patients with accessory renal artery anatomy . 
 technological differences among the different systems may make some more suited for this common anatomical variant . 
 the early clinical experience with renal denervation of accessory renal arteries highlights the importance of complete renal denervation for clinical success .