oct is an optical method which creates high - resolution images of e.g. skin through the use of infrared light and interferometry . the oct system used ( vivosight , michelson diagnostics , uk ) is a multi - beam system , with a resolution of < 7.5 m lateral , and < 10 m vertical . oct can image a cross section of the skin to the depth of 12 mm . tophi are histologically characterized by uric acid depositions in the dermis surrounded by granuloma formation with giant cells . often , either occluded or dilated vessels are described . in polarized light common for all types is granuloma formation and degenerate collagen , often surrounded by a radially arranged infiltrate of lymphocytes , fibroblasts and palisading histiocytes . among the subsets generalized ga microscopically resembles the above , while diffuse ga is characterized by collagen bundles arranged haphazardly with a circumferential lymphocytic infiltrate . we aimed to visualize biopsy - verified granulomas with and without crystals to obtain a clear reference structure . after both patients provided informed consent , they were photographed digitally , oct images were obtained both from lesional as well as normal skin , and biopsied in this order . the oct probe was placed exactly on the lesions to be biopsied , and normal skin from the same body area was also oct - imaged but not biopsied . a 50-year - old kidney transplanted male , presented to the department of dermatology of roskilde with a 58 year history of white papules on the pulpa of the right phalanx of the 2nd finger ( fig . the area had gradually expanded and measured 1.5  1 cm and the elements 12 mm . the lesions appeared as hyperreflective , rounded , cloud - like areas in oct , their upper part sharply delineated by a hyporeflective fringe . the length of the deposits was between 0.4 and 1.5 mm , and oct could visualize lesions to a depth of 1.5 mm . the surrounding tissue appeared hyperreflective like the lesions , but was delineated because of the hyporeflective fringe ( fig . a lesional biopsy showed multiple uric acid depositions in the dermis with the presence of surrounding giant cells . lesional oct scan showed changes in dermis consisting of hyporeflective , rounded and lobulated , wing - like structures found in the papular lesions of the elbows ( fig . the tissue above seemed partly compressed and a bulge equivalent to the lesion appeared in the epidermis . the vessels seemed dilated and more pronounced compared to normal skin , and the lobulated structure appeared in extension of a vessel ( fig . a 50-year - old kidney transplanted male , presented to the department of dermatology of roskilde with a 58 year history of white papules on the pulpa of the right phalanx of the 2nd finger ( fig . the area had gradually expanded and measured 1.5  1 cm and the elements 12 mm . the lesions appeared as hyperreflective , rounded , cloud - like areas in oct , their upper part sharply delineated by a hyporeflective fringe . the length of the deposits was between 0.4 and 1.5 mm , and oct could visualize lesions to a depth of 1.5 mm . the surrounding tissue appeared hyperreflective like the lesions , but was delineated because of the hyporeflective fringe ( fig . a lesional biopsy showed multiple uric acid depositions in the dermis with the presence of surrounding giant cells . lesional oct scan showed changes in dermis consisting of hyporeflective , rounded and lobulated , wing - like structures found in the papular lesions of the elbows ( fig . the tissue above seemed partly compressed and a bulge equivalent to the lesion appeared in the epidermis . the vessels seemed dilated and more pronounced compared to normal skin , and the lobulated structure appeared in extension of a vessel ( fig . noninvasive diagnostics has numerous advantages for the patient as it may obviate the need for biopsies while enhancing the diagnostic accuracy . this is of particular relevance for medically treated conditions or research where longitudinal studies of lesions are of particular interest . the cell density in the tissue plays an important role for the light scattering in oct . in principle , not unlike granulomas , bccs are cell - dense , often nodular or rounded structures , consisting of basal cells sometimes surrounded by inflamed tissue . for example the bcc islands have been described as rounded hyporeflective structures sometimes surrounded by a hyperreflective structure thought to represent the stroma . we studied two typical granulomatous structures : tophi and ga . in oct imaging granulomatous tissue surrounding urate deposits appeared as a clear hyporeflective fringe surrounding a light , hyperreflective area ( fig . the urate crystals appeared as a hyperreflective area , shielding the deeper part of dermis . vessels in images with uric acid depositions appeared more dilated compared to normal skin , probably because of the inflammation or a mechanical obstruction of the flow due to the deposit . the clear image of the urate crystals may be expected to be diagnostic for this condition . 2b1 ) revealed rounded , hyporeflective , slightly blurred areas that did not appear specific . it consisted of a confluent series of rounded unreflective areas joined in a wing - like and lobulated oblong structure . vessels presented as dilated , and the structure appeared in extension of structures that could be interpreted as dilated vessels . the long lobulated oct - imaged structure may represent an area of dense lymphocytic infiltrate as seen on histology . alternatively it may represent diffuse ga , although the diffuse granuloma in the biopsy did not look as lobulated as the structure in the oct image . these cases suggest that oct images granulomatous tissue as absorbent , hyporeflective areas , and urate crystals appear as reflective areas , obscuring the underlying tissue . in ga a new image shape looking like a wing has been found , which may either correspond with primary granulomas or the surrounding lymphocytic infiltrate . the frequency , specificity and sensitivity of this new pattern in oct imaging will require further study .
aimto investigate and compare the presentation of granulomatous lesions in optical coherence tomography ( oct ) images and compare this to previous studies of nonmelanoma skin tumors.methodstwo patients with granulomas , tophi and granuloma annulare ( ga ) , respectively , were photographed digitally , oct - scanned and biopsied in the said order . 
 normal skin was oct - scanned for comparison , but not biopsied . 
 the oct images from each lesion were compared with their histologic images as well as with oct images with similar characteristics obtained from nonmelanoma skin tumors.resultsthe oct images of the tophi showed hyperreflective , rounded cloud - like structures in dermis , their upper part sharply delineated by a hyporeflective fringe . 
 the deeper areas appeared blurred . 
 the crystalline structures were delineated by a hyporeflective fringe . 
 oct images of ga showed two different structures in dermis : a hyporeflective rounded one , and one that was lobulated and wing-like.conclusiongranulomatous tissue surrounding urate deposits appeared as a clear hyporeflective fringe surrounding a light , hyperreflective area . 
 the urate crystals appeared as hyperreflective areas , shielding the deeper part of dermis , meaning oct could only visualize the upper part of the lesions . 
 the lobulated , wing - like structure in ga may resemble diffuse ga or a dense lymphocytic infiltrate as seen on histology . the rounded structure in ga may represent an actual granuloma or either diffuse ga or a dense lymphocytic infiltrate as described above . 
 this case suggests that oct images granulomatous tissue as absorbent , hyporeflective areas , and urate crystals appear as reflective areas , obscuring the underlying tissue . in ga a new image shape looking like a wing has been found . the frequency , specificity and sensitivity of this new pattern in oct imaging will require further studies .