cross - cultural differences related to perception of health and diseases are well - known . attitudes and practices related to causation of illness , health care - seeking behavior , and acceptance of modern health care systems are determined , in part , by culture and society . one of the best studied endocrine conditions with cross - cultural differences in symptomatology is menopause . multiple studies report the variation in symptoms reported by menopausal women belonging to caucasian , japanese , chinese , and laotian ethnic groups . variations in symptoms and clinical presentation based on culture have also been reported in endocrine diseases as diverse as prolactinoma , disorders of sex differentiation , and obesity . one disease in which substantial work has been done to document cultural impact on clinical and therapeutic aspects is diabetes . caucasian parents , for example , stress on child - centered activities , whereas african - american parents expect more social support and ask for family - oriented interventions to help manage their children with type 1 diabetes . it is surprising to note , however , that the symptomatology of disease states may also vary across cultures . this cultural dichotomy is more obvious with chronic disease or in conditions with non - specific symptoms . although ample work has been done on cultural determinants of diabetes , one important aspect that has been neglected is the symptomatology of hypoglycemia . hypoglycemia is a frequently occurring , avoidable , potentially fatal , complication in both type 1 and type 2 diabetes . one of the main limiting factors of aggressive titration of treat - to - target therapy , hypoglycemia negatively impacts physical and psychological health , as well as quality of life . the symptoms of hypoglycemia are well known and are classified according to pathophysiological mechanisms ( neuroglycopenia , autonomic , general ) , clinical ( whether or not requiring external assistance ) , or biochemical ( degree of hypoglycemia ) parameters . these classifications , however , do not adequately cover the wide variety of symptoms that a patient may present . symptoms of hypoglycemia can vary based upon the degree and rapidity of development of the condition . the presenting symptoms may also be influenced by the autonomic health of the individual and may be masked by hypoglycemia unawareness . on the other hand , an individual who has undergone hypoglycemia awareness training may report subtle symptoms of neuroglucopenia . as regards to any medical illness , on the other hand , the documentation of signs corresponding to the same medical condition is physician - dependent . a trained physician will be able to extract from the history , subtle , unrecognized symptoms of hypoglycemia , which a less experienced colleague may not appreciate . much of the quality of history - taking depends upon grasp of the language or dialect that the patient and physician are conversing . an in - depth knowledge of the intricacies of word architecture of the language concerned will help the physician ferret important clinical clues . even a cursory look at thesaurus will sensitize the physician to the countless possibilities of symptom reporting . for example , the adjective  sick  has 49 synonyms , as reported in the thesaurus . cross - cultural differences in the perception of the hypoglycemia have been studied in a small qualitative  descriptive study that has been recently reported . authors compared a small cohort ( n = 10 each ) of russian - speaking slavic immigrant american women and non - hispanic non - immigrant white american women with type 2 diabetes . they observed significant differences in symptomatology of diabetes between the two groups , as well as less awareness of hypoglycemia in the slavic group . the work highlighted the different impact of hypoglycemia on individuals as well as the varied terminology with which they reported their symptoms . no such work has been performed in india , a country with numerous cultures and languages . indian doctors working in most parts of the country are called upon to manage patients from varying ethnic groups . although almost all indian doctors are multi - lingual , they may or may not be equally fluent in all the dialects that their patients speak . the authors , for example , are from haryana , considered a relatively  homogenous  state , but deal with patients speaking in hindi , haryanvi , punjabi , urdu , and english , in a wide variety of accents . this study was designed as a cross - sectional survey of diabetologists and endocrinologsts from six states of north and west india to assess whether symptoms of hypoglycemia exhibit cross - cultural variation . the states covered were gujarat , rajasthan , punjab , new delhi , uttarakhand , and uttar pradesh . a pre - tested questionnaire was administered , after taking informed verbal consent , to 88 diabetologists attending a regional continuing medical education program in july 2012 . this questionnaire listed 47 symptoms of hypoglycemia which were graded by respondents on a 5-point likert scale , as per the frequency with which they were reported by patients in their clinical practice . these symptoms included 11 general , 17 neuroglycopenic , and 11 adrenergic manifestations of hypoglycemia , as well as 8 well - characterized symptoms of nocturnal hypoglycemia . the questionnaire also captured data regarding the frequency of hypoglycemia noted in 9 types of clinical situations . descriptive statistics used included mean and median ( with range ) scores of different study variables . parametric test used included anova with post - hoc analysis ( using least significant difference ( lsd ) ) . pearson 's correlation coefficient statistics was used to ascertain correlation between years in practice and questionnaire items . the level of statistical significance was kept at p < 0.05 for all the tests . descriptive statistics used included mean and median ( with range ) scores of different study variables . parametric test used included anova with post - hoc analysis ( using least significant difference ( lsd ) ) . pearson 's correlation coefficient statistics was used to ascertain correlation between years in practice and questionnaire items . the level of statistical significance was kept at p < 0.05 for all the tests . it included endocrinologists and diabetologists from gujarat ( 32.5% ) , rajasthan ( 15.7% ) , uttarakhand and uttar pradesh ( 21.7% ) , delhi , punjab ( 25.3% ) and nepal ( 4.8% ) . mean age and years in practice of study respondents the mean age and years in practice of respondents from different states has been presented in table 1 . there was significant difference in mean age of respondents from different states ( f = 2.97 , df = 3 , p = 0.03 ) . post - hoc analysis revealed that this difference was due to significant difference in mean age of respondents from gujarat and delhi / punjab ( mean difference 6.58 years , sem-2.27 , p = 0.03 , 95% ci-0.40 - 12.76 ) . the mean years in practice were comparable between different groups ( f = 1.07 , df = 3 , p = 0.36 ) . table 2 presents the proportion of total patients ( given as median percentage and range ) seen by the respondents that presented with hypoglycaemia in various clinical situations . median values have been reported here because of wide range of standard deviation observed for mean for these variables . hypoglycaemic episodes observed by clinicians from different states within between - group comparisons table 3 presents the proportion of patients ( given as mean percentage and sd ) presenting with various general and adrenergic features of hypoglycaemia as reported by the respondents from various states . the only variable significantly difference between the groups was  can not work under pressure post - hoc analysis revealed that the difference was significant between the respondents from states of rajasthan and gujarat ( mean difference = 0.108 , p = 0.009 , 95% ci-0.27 - 1.88 ) . the mean score was significantly higher for respondents from rajasthan ( mean-2.92 , sd 1.32 ) when compared with those from gujarat ( mean-1.84 , sd 1.03 ) . general and adrenergic features of hypoglycaemia reported by respondents from different states with in between group comparisons table 4 presents the proportion of patients among those with hypoglycaemia ( given as mean percentage and sd ) presenting with various neuroglycopenic and nocturnal symptomatic features . no significant differences were observed between the respondents from different states for any of these psychologic variables . neuroglycopenic and nocturnal features of hypoglycemia reported by respondents from different states within between - group comparisons there was no significant correlation between the years in practice and any of the items of the study questionnaire . on comparing the respondents from gujarat with rest of the country , significant differences were observed on certain variables [ table 5 ] . the mean age of respondents from gujarat ( 47.24 sd 6.30 ) was lower than respondents from rest of the country ( 51.90 sd 7.70 ) . the difference was statistically significant ( t = 2.57 , p = 0.012 , 95% ci 1.05 - 8.28 ) . the clinical features of  inability to work under pressure  ( general symptom ) was encountered more frequently by the respondents from gujarat among their gujarati - speaking patients when compared with respondents from rest of the country , who managed hindi - speaking patients ( t = 2.49 , p = 0.015 , 95% ci 0.14 - 1.34 ) . ( hyperadrenergism ) ( t = 2.68 , p = 0.009 , 95% ci 0.19 - 1.36 ) ,  feeling down over nothing  ( neuroglycopenia ) ( t = 2.75 , p = 0.008 , 95% ci.20 - 1.30 ) , and  crumpled bed sheets upon waking up ( nocturnal hypoglycemia ) ( t = 2.35 , p = 0.023 , 95% ci 0.08 - 1.02 ) were encountered at a significantly lower frequency by respondents from gujarat when compared with respondents from rest of the country . however ,  intense hunger  ( adrenergic symptom ) was encountered at a significantly higher frequency by respondents from gujarat ( t = 2.49 , p = 0.015 , 95% ci 0.14 - 1.28 ) . between - group differences for respondents from gujarat and rest of india data from nepal were not considered for statistical analysis in view of the small number of study participants ( n = 4 ) . they encountered a higher incidence of hypoglycemia of all types related to all clinical situations , except for reactive hypoglycemia . symptoms which were reported more often in nepal included feeling of illness , weight gain , palpitations , sweating , and trembling . some symptoms such as butterfly stomach this is the first study in the world , to the best of our knowledge , to objectively study the potential cross - cultural and cross - linguistic differences in symptom reporting of hypoglycemia in patients with diabetes . this study utilized the responses of 88 experienced diabetologists and endocrinologists , with years of clinical experience . this helped gather information from a much larger pool of patients than would have otherwise been possible . when asked to report the symptoms with which their patients presented , their responses varied according to language of patients . gujarati - speaking patients tended to report a greater inability to work under pressure , and a higher frequency of intense hunger , during hypoglycemia , to their doctors . they were less likely to report specific adrenergic ( inward trembling ) , neuroglycopenic ( feeling down over nothing ) , and nocturnal ( crumpled bed sheets upon waking up ) symptoms as specified above . these findings highlight the potential cross - cultural and cross - linguistic variations in patient perception of hypoglycemic symptoms . diabetes care providers should be aware of the possible differences in reporting of hypoglycemic symptoms by patients belonging to different linguistic and ethnic groups . the ability to elicit a detailed history of hypoglycemia is not only part of general clinical competence , but should be also be highlighted as a domain of cross - cultural competence . physicians were asked to rate the frequency of various symptoms reported by their patients rather than asking patients directly . physicians in their busy practice tend to ask leading questions , and a lot of time our patients just try to be affirmative . the questionnaire was prepared in english rather than in local languages which the patients spoke ( hindi , gujarati , punjabi , nepali ) . the english translations may not have conveyed the nuances of the patient - reported symptoms . the study which was planned as an all - india exercise had to be limited to north and west india due to unforeseen circumstances . the sample of the physicians in number and distribution is probably not well powered to represent the large community of indian diabetologists . in spite of these issues this study has strengths which warrant its publication and dissemination . this is the first study in india , rather in the world , to the best of our knowledge , to objectively study the cross - cultural or cross - linguistic variation in symptomatology of hypoglycemia . it makes use of appropriate statistical tools to quantify the significance of such differences using physician - reported data , based on their clinical experience of treating vast number of patients , it takes advantage of a much greater pool of patients , through their physicians , than would have been possible using a direct face - to - face interview method . the questionnaire itself works as a therapeutic education tool for both physicians and patients , prompting them to elicit and offer relevant medical history and help them improve communication skills related to hypoglycemia . measuring diabetes health beliefs in a south asia population a recent review highlights the virtual lack of literature and the difficulties in comparing existing studies in this field , from a part of the world which faces the brunt of the diabetes pandemic . keeping this in mind it has added significant contribution to world literature on hypoglycemia perception as an aspect of medical anthropology , and should stimulate larger studies on this topic in india and other parts of the globe . cross - cultural care and multi - linguistic care is a part and parcel of an indian diabetologist 's work . what needs to be emphasized , however , is the need for cultural and linguistic competence as well . this will encompass , among other issues , an understanding of the varied symptoms of hypoglycemia reported by patients from different ethnic and language groups .
background : cross - cultural differences in attitudes and practices related to diabetes are well - known . 
 similar differences in symptom reporting of endocrine conditions such as menopause are well documented . 
 minimal literature is available on the cross - cultural variation in reporting of hypoglycemic symptoms.aims:this cross - sectional study aimed to assess the symptoms of hypoglycemia encountered by diabetologists who deal with patients from different language groups from various states of north and west india and nepal.materials and methods : eighty three doctors from six indian states and nepal , attending a continuing medical education program were requested to fill a detailed , pre - tested , likert scale based questionnaire which assessed the frequency and symptoms with which patients presented with hypoglycemia in their clinical practice . 
 data were analyzed based on geographic location of the diabetologists and language spoken by their patients ( hindi vs. gujarati).results : gujarati - speaking patients tended to report to their doctors , a greater inability to work under pressure and a higher frequency of intense hunger during hypoglycemia . 
 they were less likely to report specific adrenergic ( inward trembling ) , neuroglycopenic ( feeling down over nothing ) , and nocturnal ( crumpled bedsheets upon waking up ) symptoms.conclusion:significant cross - cultural differences related to the symptomatology of hypoglycemia are noted . 
 indian diabetologists should be aware of the varying presentation of hypoglycemia based on language and ethnic background .