the best corrected visual acuities were 10/20 in the right eye and 20/200 in the fellow eye . fundoscopic examination via indirect ophthalmoscopy revealed minimal macular edema in the right eye and diffuse pigmentary changes as well as peripheral retinoschisis in the fellow eye [ fig . 1 ] . cartwheel - like configurated radial striates as well as fine cystoid changes in macula were seen in fluorescein angiography ( fa ) of the right eye and diffuse punctate filling defects were revealed in fa of the left eye [ fig . 2 ] . bilateral foveal retinoschisis was evident on optical coherance tomography ( oct ) [ fig . 3 ] . bilateral subnormal rod responses in scotopic electroretinogram ( erg ) and subnormal flicker responses were present ; however , they were more pronounced in the left eye . besides , a selective decrease in b - wave amplitude on photopic cone responses which is characteristic for retinoschisis was evident for the subject . peripheral retinoschisis in the left eye ( c ) ; laser spots around the peripheral retinoschisis lesion ( d ) radial striates and fine cystoid changes of the right eye ( a ) and diffuse punctate filling defects of the fellow eye ( b ) in fluorescein angiography foveal retinoschisis in the oct images of right ( a ) and left ( b ) fundus ; oct images of right ( c ) and left ( d ) fundus at the second year of follow - up in order to avoid the potential risk of retinal detachment , argon laser photocoagulation was performed around the peripheral retinoschisis lesion in the left eye [ fig . after the second year of follow - up visual acuity remained stable , also fa [ fig . 3 ] and fluorescein angiography of right ( a ) and left ( b ) fundus at the second year of follow - up . the constant diagnostic feature of xlrs is bilateral foveal retinoschisis , whereas peripheral retinoschisis may be present approximately half of the affected male patients . tangential splitting of the neurosensory retina caused by the defect of cellular adhesion and cell  cell interactions within however , disease is commonly presented with reading difficulties due to the foveoschisis in school - age children , it can be diagnosed with nystagmus or strabismus in infancy . prognosis is poor because of the progressive maculopathy , moreover sudden visual loss due to retinal detachment or intravitreal hemorrhage may be seen in cases with peripheral retinoschisis . clinical photographs of retina and cross - sectional images of oct help confirming the diagnosis and determining the management of the disease . existence of mild window defects and absence of fluorescein leakage on fa as well as presence of a selective decrease in b - wave amplitude on both scotopic and photopic testing of erg are also characteristic findings for differential diagnosis . confirming rs1 gene mutations on genetic molecular testing is an emerging diagnostic parameter for the affected patients without a family history . however most of the retinoschisis cavities remain stable and rarely extend to the posterior pole , many authors suggest laser prophylaxis . reported the success of prophylactic argon laser photocoagulation in the asymptomatic stage of bullous retinoschisis with outer layer breaks . gopal et al . also reported the beneficial effect of prophylactic photocoagulation in collapsing the schisis cavities . successful treatment with laser photocoagulation in one of three cases of posteriorly situated retinoschisis - retinal detachment was reported by ambler et al . jo et al . published the data of the first case of spontaneous regression of retinoschisis as observed by oct in the literature . on the other hand , some authors do not recommend prophylactic treatment of retinoschisis in the absence of combined retinal detachment ; moreover , they stated the increased risk of retinal tears and iatrogenic retinal detachments after the heavy photocoagulation burns . in the present case , we performed prophylactic argon laser photocoagulation to the posterior margin of retinoschisis cavity . at the end of the second year of follow - up , both fundoscopic examination and visual assessment remained stable . although there is no proven guideline for both the laser prophylaxis and the treatment of retinoschisis , laser photocoagulation , cryotherapy , scleral buckle , and parsplana vitrectomy are considered as the main treatment options especially in cases with vitreous hemorrhage or retinal detachment .
x - linked juvenile retinoschisis is a rare hereditary retinal disease characterized by a tangential splitting of the neurosensory retina which may cause early - onset visual impairment . 
 existence of the retinal neurosensory layer splitting on cross - sectional images of optical coherance tomography ( oct ) and the absence of leakage on fluorescein angiography ( fa ) help confirming the diagnosis . 
 such diagnostic tests are also helpful in determining the management of the disease . however , most of the retinoschisis cavities remain stable and rarely extend to the posterior pole , many authors suggest laser prophylaxis to avoid the potential risk of retinal detachment due to holes in the outer retinal layer . 
 herein , we report a case with bilateral foveal retinoschisis accompanying unilateral peripheral retinoschisis who was evaluated with detailed ophthalmologic examination . 
 visual acuity , fundoscopy , oct , and fa remained stable in the second year of follow - up after prophylactic argon laser treatment .