in 2012 , the court of appeal of leeuwarden , the netherlands dealt with the case of s.h . , a young woman who is accused of suffocating her four newborn children , during or shortly after birth by covering their nose and mouth and/or throat with a pillow . subsequently , she would have put the babies in litterbags which she left in a suitcase in the attic of her parents ' house . a first instance court presumed that she took the decision to kill the children out of fear of discovery of her pregnancies . the first instance court imposed a prison sentence of 12 years because of infanticide : three times murder and once manslaughter of the four newborn children . when the case is with the court of appeal , the defendant agrees , after having refused this until then , to be examined by a psychiatrist , a psychologist and a behavioral neurologist . in the decision , the court of appeal quotes part of the conclusions of the experts which add a neurobiological perspective to the case : thereby it is established that the defendant has a personality disorder which is associated with or is ( co)-determined by cerebral organic damage in the sense of a frontal syndrome and that this disorder has restricted her to a considerable extent , compared to a healthy person , in overseeing the problems which she faced and in making choices to solve these problems . as a result of this disorder , the experts believe that the accountability of the defendant for the crimes is substantially reduced . in addition , they say that to prevent criminal recidivism , prolonged treatment and counseling is needed . taking into account these expert reports , the court of appeal , in contrast to the first instance court , finds that it can not be proven that the accused had already decided to kill the children before the births . the court of appeal sentences s.h . for four times manslaughter with a tbs order with mandatory hospitalization and a prison sentence of three years the tbs order (  terbeschikkingstelling ,  entrustment order , art 37a criminal code ) can be imposed upon mentally disordered adult offenders who are considered not responsible or of diminished responsibility for their offense(s ) , and who are perceived as a severe danger to others or society . this case illustrates how the information of the experts , about damage to the frontal brain and its presumed cognitive and behavioral consequences , is used by the court to help answer the judicial question of accountability and to determine a sentence . researchers in the usa report already for some time about the use of neuroscientific information in criminal justice practice . the number of criminal cases in the database westlaw in which the judge mentions neuroscientific evidence in his or her opinion has allegedly increased from 112 in 2007 to more than 1500 in 2011 . , neuroscientific information and techniques have found their way into the courts of the netherlands as well . furthermore , following a penalty reduction for a mentally ill offender in an italian case because of a to gain more insight in the ways neuroscientific and behavioral genetic information are used in criminal justice practice in the netherlands , wodc systematically collects dutch criminal cases in which neuroscientific or behavioral genetic information is introduced . in this paper , we describe types of criminal cases ( eg types of offenses , expert assessments , and penalties ) , and subsequently explore for which judicial questions neuroscientific information is sought , and whether it is used in a mitigating or aggravating way . for each judicial question , two prominent ones are pre - frontal brain damage in relation to criminal responsibility and recidivism risk , and diverging views of the implications of the growing knowledge about neurocognitive deficits in addiction for judging criminal responsibility . the cases also illustrate the role of neuropsychological methods in criminal cases , whereas in contrast in the  neurolaw literature the emphasis is often on imaging techniques . it is concluded that there is a clear need of practice oriented instruments and guidelines . first however , the methods used for finding , selecting , and analysing the case law are described . furthermore , in the appendix , we give background information about numbers of criminal cases and publication practice with respect to case law in the netherlands , and its consequences for the quantity and quality of the case law data used in this paper . decisions in criminal cases published in the years 200012 were searched in the dutch case law database of  rechtspraak.nl. this database is operational since 2000 and has been progressively filled each year since then . in the netherlands however only a small proportion of the total number of criminal cases that come before the courts each year are published , and this is not necessarily a representative set of the total number of cases ( see appendix for more details on this matter ) . this means that , although we analysed all available published cases in the netherlands in which neuroscientific or behavioral genetic information is introduced , which is a valuable source of qualitative information , we can not draw general , quantitative conclusions on the basis of our dataset about how neuroscientific information is used in dutch courts . this is because we do not know how many unpublished cases there are that would fit our selection criteria , or whether our dataset is representative of the total number of criminal cases in which neuroscientific or behavioral genetic information is introduced . mri ,  ct - scan ,  pet - scan ,  electro - encephalogra* , maoa. from the cases found ( table 1 ) , those were selected in which neuroscientific or genetic information is introduced with respect to the suspect / defendant , and ( 1 ) neuroscientific or ( 2 ) genetic information is raised in relation to ( a ) behavior ( eg aggression , violence , addiction ) , ( b ) brain function ( eg memory , perception , cognition , self - control ) , or ( c ) mental state ( eg consciousness , automatism , psychosis ) . searching and selecting criminal cases in which neuroscientific or behavioral genetic information is introduced . the total number of criminal cases published on rechtspraak.nl contains both crimes (  misdrijven ) and less serious offenses (  overtredingen ) , although in practice mostly the more serious and complex cases are published ( see text for criteria for publication in rechtspraak.nl ) . furthermore this total number of criminal and offense cases contains not only first instance court cases but also cases of the courts of appeal and of the supreme court of the netherlands . two extra cases found with other search terms :  arousal , and  aangeboren (  inborn ) were also included . considered as neuroscientific information is information from ( 1 ) assessment of the brain with imaging techniques ( such as mri , spect , pet ) or eeg , neuro - endocrinological assessment ( eg hormones , neuropeptides ) , ( 2 ) neuropsychological assessment , or ( 3 ) referring to a certain neurobiological predisposition or damage of the brain . considered as behavioral genetic information is information from ( 1 ) heritability assessment , eg assessment of specific genes or ( 2 ) referring to a  genetic predisposition or a family history that seems to indicate a biological origin of a particular behavior . it was coded to what extent the neuroscientific or genetic information affected the decision of the court about criminal responsibility of the defendant . yes , the neuroscientific or genetic information was decisive ( for instance the court mentions neuroscientific information as a basis for acquittal or no accountability for the offense ) ; partly , the neuroscientific or genetic information affected the decision partly ( for instance neuroscientific information is mentioned by the court as a basis for the decision together with other factors such as a psychiatric interview that reveals a personality disorder ) ; no , the neuroscientific or genetic information did not affect the decision ( for instance there was a neurobiological problem but this was not treated by the court as relevant for the decision about accountability for the offense ) ;  not applicable , for cases where the question of criminal accountability is not central ( for instance in some of the supreme court cases that focus on a judgment of the work of the court of appeal ) . information about the subjects mentioned above was extracted from each case using a scoring instruction . in order to ensure consistency of scoring behavioral genetic information is involved in 14 cases , and in another 10 cases neuroscientific information as well as behavioral genetic information is involved . of the 231 cases found , 178 were first instance court cases , and there were 45 court of appeal cases , and eight supreme court cases . a minority of cases ( 22 ) concerned the continuation or termination of a tbs- or an isd - order . serious offenses and long sentences are at issue , although a wide range of offenses and penalties occur ( tables 2 and 3 ) . in the majority of cases , a prison sentence and/or a measure for high - risk offenders ( tbs , isd or pij ) is imposed . in 191 of the 231 cases the remaining cases consisted of supreme court cases ( n = 8) , extension or termination of a tbs- or isd - order ( n = 22 ) , cases in which the offense was declared not proven ( n = 5 ) , suspension of prosecution : ( n = 2 ) , or  other cases ( n = 3 , see legend of table 3 ) these cases concern respectively : rejection of a claim for cancellation of parole , founded statement of objection , and an interlocutory judgment . it is understandable that neuroscientific information is mainly ( but not only ) introduced in cases with a serious violent or sexual offense and with severe penalties at stake , because in such cases it is likely that a report of a behavioral expert on the mental capacities of the defendant will be requested . in 175 of the cases found , two or more behavioral experts reported to the court . we found no cases in which an mri - scan was shown in court in relation to the brain and behavior of the defendant or was central in the reasoning about this . we know however that mri - scans are often part of the interdisciplinary examination of the defendant in cases where pre - frontal damage , for instance pre - frontal dementia is suspected . furthermore , it has been estimated that in assessments of suspects of serious offenses by the netherlands institute of forensic psychiatry and psychology ( nifp ) , an mri - scan is made in about half of the cases . typically in the serious violent or sex offense cases we found , the neuroscientific information provided is part of a larger picture about the defendant to which experts of several disciplines contribute , usually psychiatry , ( neuro ) psychology , the probation service , and other disciplines such as neurology if considered necessary . different methods are used to gain insight in the person of the defendant and his mental condition at the time of the offense depending on the case , for instance psychiatric interviews , psychological and neuropsychological tests , collateral reports , and neurological investigation . in the criminal cases found , neuroscientific or behavioral genetic information is introduced with respect to a variety of judicial questions , in fact all the main questions that have to be addressed subsequently in the dutch criminal trial and sentencing ( table 4 ) . neuroscientific information is most often used for the question whether the defendant can be considered of diminished accountability for the offense ( 72 cases ) . such cases typically concern serious violent offenses and defendants who may have a mental disorder or defective development . in 15 cases , neuroscientific information is subsequently used to help answer the question to what extent the defendant is a risk to society . the next largest categories are cases in which neuroscientific information is used in the context of the question whether the defendant intended the unlawful act ( 20 cases ) , or if the unlawful act was due to guilt / negligence of the offender ( 14 cases ) . in other cases , a traffic accident had happened that was possibly due to a temporary loss of consciousness of the defendant . in smaller numbers of cases , neuroscientific information is brought up in relation to the question whether there is sufficient evidence to prove beyond reasonable doubt that the defendant committed the offense , whether the defendant was competent to stand trial , if the defendant was subject to duress or excessive self - defense , or whether the defendant premeditated the offense . in the following , judicial questions with respect to which neuroscientific or behavioral genetic information is introduced . a criminal case is only included with respect to a specific judicial question if in the description of the case neuroscientific information is explicitly linked to answering the same judicial question . because this may concern more than one judicial question per case not in all the case descriptions an explicit association can be found between the neuroscientific or behavioral genetic information introduced and the answering of one of the specific legal questions mentioned in table 4 . neuroscientific information is used to describe the etiology of a disorder ( n = 15 ) ; it is stated that further neuroscientific assessment is needed or should have been conducted ( n = 18 ) ; no information is given in the description of the case about the results of the neuroscientific assessment mentioned ( eg there is a reference to a neurological report , but without information on the content , and no information about the legal question for which the information is sought ( n = 14 ) ) ; no aberration or indication for an aberration was found in the neuroscientific assessment , and it is not clear from the case description for which legal question , if any , the information is used ( n = 22 ) ; the neuroscientific assessment indicates an aberration ( eg a stroke several years ago ) , but the aberration is not considered in relation to the criminal behavior of which the person is accused , and the information is not used with respect to any legal question in the case ( n = 4 ) ; the neuroscientific information relates to a statement or a defense that does not lead to any further investigation or any conclusions in the case concerned ( n = 17 ) . in some cases , references to neurological symptoms are used in the context of the reliability of evidence that the defendant has committed the offense , for instance the reliability of statements . an example concerns a woman accused of attempted manslaughter of her partner whom she stabbed in the face after a quarrel between them . the defendant argues that she was confused during her interrogation by the police , due to a mild concussion , and that she therefore made false statements . the court finds this statement not relevant for its judgment , and argues that there was no indication that the defendant was so distraught during questioning that she was not able to make any useful statement . nevertheless , cases where the effect of brain damage on the reliability of statements is at issue in a more substantial way form an interesting category . in an unpublished criminal case described by jelicic and merckelbach , a woman in her 30s falls down the stairs after a quarrel with her boyfriend . the boyfriend states that he went to bed earlier than his girlfriend and woke up from the noise of her falling . it is not clear if she lost consciousness after the fall , but during the first days in hospital she is disoriented and does not understand where she is and why . according to the authors , this and the fact that she later remembers little of her hospital period are indications of post - traumatic amnesia . furthermore , the woman suffers from retrograde amnesia : she can not remember events that happened shortly before she fell . months later she complains about loss of the sense of smell , and about continuing problems with imprinting new information , although she scores in the normal range on memory tests . according to her neuropsychologists , these may be lingering signs of her brain contusion . half a year after her hospitalization , the woman ends the relationship with her boyfriend , because it disturbs her that he keeps going out a lot with his friends and frequently comes home drunk . three years after her fall , the woman starts to remember that she did not just fall from the stairs , but was pushed by her boyfriend . his lawyer asks the investigative judge to appoint an expert to investigate the plausibility that the woman can remember being pushed of the stairs by the defendant . the psychologist writes that an emotional event , such as this , is likely to be remembered better than a neutral event . furthermore , because according to the psychologist , the woman showed a relatively fast recovery , as is usual with light brain damage , the psychologist does not consider it peculiar that the memories of the event have come back . however , the lawyer of the boyfriend asks the judge to appoint other experts to look critically at the report of the clinical psychologist . these contra - experts argue that according to doctor 's reports about eeg abnormalities and the amnesia after the fall , the woman did suffer serious brain damage . they state that from a neurobiological perspective , it is unlikely that her retrograde amnesia would have fully recovered . the contra - experts describe that this has to do with the way memories are stored . information is first transferred to the hippocampus , and subsequently from the hippocampus to the brain cortex . the second step is essential for retaining memory information , and takes several minutes to complete . in the case of a blow to the head the contra - experts state that the judge appointed another expert after them , a professor of neuropsychology , who confirmed their conclusion . although it remains unclear why the woman , three years after the incident , suddenly claimed the retrieval of memories of the event , this case is interesting because it illustrates the potential role of neuropsychological knowledge about the impact of different forms of brain damage on cognitive functioning for answering questions about reliability of statements of witnesses , victims , or defendants with brain damage . neuropsychology does not feature by far as prominently in the literature about neuroscience and law as do neuroimaging techniques . yet , neuropsychology may be helpful to law in several ways . in the last decades , neuropsychological research for instance has indicated deficits in the so - called  executive functions in populations with severe ( impulsive ) antisocial behavior . executive functions are important for self - regulation , the ability to direct one 's behavior and thinking . examples of executive functions are : the ability to focus one 's attention , the capacity to control impulses and strong emotions , the ability to plan ahead and to postpone direct satisfaction in order to reach long term goals , flexibility in adapting behavior in reaction to feedback from the environment , and the functioning of short - term memory . deficits in executive functions are associated with a less optimal development of or damage to the pre - frontal brain . furthermore , neuropsychologists have developed a range of tests ( nowadays often computerized tasks ) that are used for the assessment of brain functioning in relation to training and therapy . neuropsychological tests also often have several norm groups to compare individual scores with to assess whether they fall in a range that may be an indication for training or treatment . on the individual level , neuropsychology may at present have more to offer than brain imaging . for instance with respect to development of the adolescent brain , neuroscientists indicate that , although their imaging research helps to show that as a group adolescent brains differ in important aspects from adult brains , mri - scans can not be used in individual cases yet to , for instance , predict which juvenile has an increased chance of high - risk behavior on the basis of his or her brain development . neuroscientific information can also play a role in determining whether the defendant is competent to stand trial . in one case , a neurologist and a neuropsychologist found that the defendant had a range of neurocognitive problems arising from previous cerebral hemorrhage and infarction . this resulted in impairments in orientation , attention , language and speech , memory , executive control functions , and visual perception . the problems were perceived to interfere with the  ability of the defendant to understand the prosecution against him. therefore , the prosecution was suspended . we found only a few cases in which neuroscientific information was introduced in relation to fitness to stand trial , and all of these concern accused persons who were mentally severely handicapped . in these cases , the neuroscientific information appears to support and further strengthen or buttress the evidence about impairments already overly apparent from the person 's behavior . in several of the criminal cases found , neuroscientific information is introduced with respect to legal questions about intent or guilt . in most of these cases , to shed more light on the question whether the defendant was aware of committing the act in question . in one case , a woman is suspected of manslaughter because she allegedly shot at someone around 2:30 am during new year 's night . the defendant says she can not remember anything of what happened after she went to bed at 2:00 am . dissociative state. the defendant has been a member of a shooting club for a long time , and claims to have dreamt that she was at the shooting range , aiming at cards with vague images . the psycho - physiologist compares the woman 's case to guidelines for determining the possible role of a sleep disorder in violent behavior . he concludes that it is likely that the defendant has committed the violent act during sleep . he reports inter alia that during the first phase of deep sleep , the activity of the frontal cortex of the brain is greatly reduced and that this was also the case in the defendant during sleep registration . he explains : the disconnection between the frontal cortex and other parts of the brain during deep sleep can lead to automatic behavior . in this state but because the controlling role of the frontal cortex has been  turned off , the person is no longer aware of his own position relative to that environment . at that moment one it can therefore not be said that someone in a situation of automatic behavior , such as sleepwalking , acts consciously . the defendant is acquitted because the court considers it likely that she acted unconsciously , and therefore intent is not proven . we found one more case in which the defendant appeared to have committed a violent act during sleep . that case concerns a young girl who wounds her friend who sleeps over with a knife . in both these cases , it was not proven beyond reasonable doubt that the defendant intended the act , and the defendant was acquitted . in both cases , the psycho  physiological sleep assessment that identified a specific sleep disorder played an important if not crucial role in this conclusion .  violence during sleep-cases there is considerable knowledge about the neurobiological mechanisms that play a role in sleepwalking disorders . in the area of violence during sleep the guidelines indicate ways to diagnose different sleep disorders that may lead to acting without conscious awareness . furthermore , the guidelines offer ways to recognize whether the behavior at the time of the unlawful act corresponded to what would be expected from a person with a sleep disorder , and how to differentiate this from simulation . guidelines and protocols for the use of neuroscientific information in criminal cases could serve to articulate the state of knowledge , and the ways in which neuroscientific information can and can not be used . they may be advisable in other areas as well where , at least in the netherlands , guidelines or protocols do not yet exist . for instance in the case of a defendant with pre - frontal brain damage , a mental disorder such as schizophrenia , addiction , or learning disabilities . furthermore , several authors state that a protocol could also be helpful to prevent biases in the assessments of experts . merckelbach and merckelbach argue that neurobiological ( eg mri ) assessments by experts in the context of a court are sensitive to the  pathology bias ( the inclination of clinicians to see deviance because it is suggested by the context ) , the  allegiance bias ( the assessments are biased in a certain direction dependent on the process party that hired the expert ) , and malingering ( for instance the faking of test results by the defendant ) . blinding of the expert to context variables ( for instance about the background of the defendant ) and symptom validity testing ( to assess malingering ) would according to them be essential components of a protocol for the use of neuroscientific evidence in court . in another criminal case , the question is whether the defendant is guilty of a car accident . a man caused a serious accident by driving onto the sidewalk and hitting several pedestrians . however , he does not remember anything about the accident and claims to have had a black out. he is seen by a neurologist who finds a perfusion defect in the brain that probably was already there at the time of the accident . the court of appeal considers it likely that this defect caused the defendant to lose consciousness for a short period which made him lose control over his car . the court of appeal concludes that it can therefore not be proven that he is guilty of the accident , and the defendant is acquitted . we found several criminal cases in which a car accident had happened , and the question is whether this was caused by a temporary reduced consciousness or lack of consciousness of the defendant . in these cases , the courts appear to apply the so - called  culpa in causa principle . if loss of or reduced consciousness during the incident seems to have been likely , the subsequent question is whether the defendant could have known that the risk existed that he would have such a if that is the case , the defendant is considered responsible for taking the risk of an accident that would happen , and it is unlikely that he will be acquitted like in the above case where a previously unknown defect appeared to have caused the black out . in the largest category of the criminal cases found , neuroscientific information is introduced in relation to the question to what extent the defendant can be held accountable for the offense . the consequences of damage to the pre - frontal brain for the behavioral choices the person had at the time of the offense are a theme in several of the cases . an example is a case of a man who is accused of fornication with a neighbor - girl . the abuse took place four or five times when she was about nine years old . the defendant is examined by a neurologist who finds a beginning of front - subcortical dementia in relation to parkinson 's disease . the behavioral choices of the defendant at the time of the offense were according to the neurologist , undoubtedly affected by the organic brain dysfunction . he reports : directly related to the front - subcortical dementia is , in addition to the characteristic cognitive impairments , impulsivity , which occurs particularly in complex situations in which the defendant lacks an overview . as a result the defendant lacks the capacity for self - reflection , which prevents him from relating his actions to an appropriate framework of norms and values . in addition he was as a result of his cognitive impairment not able to interrupt his behavior once started . the other behavioral expert , a psychologist reports that the dementia is in an early phase and that the behavior of the defendant shows not a general disinhibition yet . the court adopts the advices of the experts and considers the defendant of diminished accountability for the offense . the verdict is a 297 days prison sentence , of which 60 days conditional and with two years of probation and psychogeriatric treatment as a special condition . the dementia and the cognitive impairments and impulsivity appear to be weighed as a mitigating factor for criminal responsibility in this case , and are also seen as a risk for which supervision and treatment are needed . in a different case , information about pre - frontal brain damage is used to underpin whether or not the defendant premeditated the offense . a man stabs his wife with a knife after which she dies from the wounds . the neurologist reporting in this case concludes that the defendant suffers from a slight  frontal syndrome ( damage to the frontal brain ) as a result of which he lacks impulse control and is unable to interrupt his behavior once started . the court argues that normally it could be inferred from a situation like this that the defendant had time and opportunity to reflect on his actions , and that therefore one could conclude that the defendant premeditated the offense . however , the court concludes that because of the slight frontal syndrome , the defendant was probably not capable of such a reflection and therefore premeditation is not proven . in this case , much value is apparently assigned to the neurological information . because of the slight frontal syndrome and its assumed consequences , the defendant is not sentenced for murder but for manslaughter . the court concludes that from expert reports it appears that the defendant should be considered of reduced accountability at the most and imposes a prison sentence of nine years . in conclusion , in most of these  accountability - cases the neuroscientific or behavioral genetic information appears to be used as mitigating information . as shown earlier , in 72 cases ( table 4 ) neuroscientific or behavioral genetic information is introduced with respect to the question of accountability of the defendant for the offense . in 67 of these cases , the neuroscientific or genetic information influenced the decision with respect to accountability of the defendant . in the majority of these cases ( 55 ) , the defendant is considered of diminished accountability and in six cases not accountable , based ( in part ) on the neuroscientific information . in another six of the cases , the defendant remains to be considered fully accountable ( partly ) on the basis of neuroscientific information . in eight of the cases not the neuroscientific information , but other factors appear to affect the judgment with respect to accountability of the defendant . in the previous section , it was argued that in most of the cases , we found neuroscientific information to have a mitigating influence with respect to accountability . however , the other side of the coin might be that neurobiological deficits may be considered as contributing to criminal recidivism risk , particularly when they are seen as untreatable . in that case in most criminal cases where a serious crime is at issue , the court considers the criminal recidivism risk of the offender . the behavioral experts who report in such cases , a psychiatrist ( mandatory according to the law ) and usually a psychologist , can be requested to advise about the risk of criminal recidivism . in 15 of the criminal cases , we found , neuroscientific information is explicitly mentioned in relation to the criminal recidivism risk of the defendant . an example is a case of a man who is convicted to a conditional prison sentence of three months because of stalking . he has harassed his former girlfriend repeatedly with emails , phone calls , and unwanted visits because he allegedly had a strong motivation to repair the broken relationship . the report about the mental capacities of the defendant describes a personality change due to brain damage . according to the behavioral expert the court decides that the accountability of the defendant for the stalking is strongly diminished , but argues that because of the impaired ability of impulse control , the risk of recidivism is substantial . therefore , treatment and supervision to prevent recidivism is urgently needed according to the court . the court takes into account that no violence was used and imposes a conditional prison sentence of three months with two years of probation . in another case , the defendant had sent letters containing shotgun cartridges and bullets to a large number of prominent persons , such as politicians and television personalities , in which he threatened to kill them and their families . he also possessed fire arms at home , which is generally prohibited in the netherlands . a psychiatrist and psychologist report to the court about the defendant . according to them , brain damage as a result of a traffic accident 19 years ago strongly affected his behavior at the time of the offenses . the organic damage leads to increased irritability , impulsivity , and an inability to weigh the consequences of behavioral choices . the behavioral experts reason that because the organic brain defects will remain stable , there is a risk of renewed threatening behavior . however , they consider the risk that the threats will amount to actual physical aggression to be very small , because the defendant is avoidant of direct personal contact and conflicts . in this case , the experts see the organic brain defects as untreatable . they however do see chances for improvement via supervision and medication of the general condition and behavioral regulation of the defendant in such a way that the recidivism risk may be reduced . these two cases are interesting because they illustrate that although the brain damage and cognitive deficits are seen as unchangeable and as the source of criminal recidivism risk , the behavioral experts and the court nevertheless see opportunities for improvement that may lead to a reduction of the recidivism risk . double edged sword , mitigating with respect to the accountability of the defendant but aggravating with respect to sentencing because of the perceived untreatable recidivism risk , is thus at most partly confirmed in these cases . for courts in the netherlands , the most common way to look at offenders who committed their offense while intoxicated by alcohol or other addictive substances is indicated by the  culpa in causa principle . , culpa in causa is used in criminal law to indicate that someone ended up in a situation that results in an unlawful act because of his or her own fault and therefore is responsible for it . whereas in the criminal law sector addiction seems to be seen more as a choice , in the medical sector addiction is seen as a ( brain ) disease . according to the brain disease model , chronic drug use induces enduring changes in brain function that impair the person 's ability to control drug use . for instance only a minority of the people who start using drugs or alcohol develop an addiction , and a subset of people more likely to become addicted can be identified on the basis of genetic risk factors . furthermore , neuroimaging studies have revealed structural changes in the  reward circuitry of the brain of addicted persons and in brain circuits that are implicated in cognitive control , compared to non - addicted persons . according to the brain disease model , these brain changes explain the maladaptive cognitive processes seen in addicted persons , such as heightened attention to the addictive substance , impaired ability to control strong emotions or inhibit intentional actions , and problems in making adaptive decisions . although the  culpa in causa principle prevails , the neuroscientific knowledge about addiction that has developed during the last decades appears to be affecting the way addicted offenders are perceived by actors in dutch courts , mainly by the behavioral experts . it seems that the neurobiological knowledge is triggering questions and discussion about the consequences of addiction and long - term substance abuse for brain functioning and behavioral choices of the defendant . a practical example is a case of a defendant who committed murder during an amphetamine psychosis . the psychiatrist who reports to the court argues :  the accused was free to choose or not choose to start with amphetamine long ago . however , generally a long existing addiction has irreversible effects on the brain that limit the freedom to determine one 's will to use substance. for this reason , the psychiatrist advises the court to consider the defendant of diminished criminal responsibility . the accused should have known amphetamine can lead to a psychosis , and advises the court to consider the defendant completely responsible . the court of appeal leeuwarden adopts the reasoning of the first expert . but in the final judgment in this case the court of appeal arnhem to which the case has been sent by the supreme court after the latter quashed the verdict of court of appeal leeuwarden , says that the defendant should have known that amphetamine could have consequences to his psychological well - being . because the defendant voluntary started to use and continued using the drug , the court of appeal arnhem does not consider him of diminished responsibility for his criminal acts because of the amphetamine psychosis ( although he is considered of partly diminished responsibility because of a narcissistic personality disorder ) . neuroscience may help criminal law practitioners to understand better the mechanisms of obstacles to self - control in addicted persons . furthermore , as kennett points out , neuroimaging and neuropsychological testing may provide objective measures of for instance hyper - responsiveness to substance - related stimuli , impairments in self - control , and decision - making . such instruments may ( eventually ) help identify those addicts who have such severe problems with self - control and decision - making that they should be considered of diminished responsibility . at present , researchers work on a range of neurocognitive instruments . , , an indication that these may be promising for the criminal justice context too , is that in clinical practice , neurocognitive measures have shown to be better able to identify addicted persons with a high risk of relapse than do traditional clinical instruments such as questionnaires or structured interviews . , , in a minority of the criminal cases found , information about head injury or brain damage is used to argue that the defendant was extra vulnerable to duress . in some cases , it is argued in the context of self - defense that because of a head injury or brain damage the defendant may be extra vulnerable for a  state in which strong emotions prevail(hevige gemoedstoestand ) , and may therefore be more likely to use excessive self - defense . the defense argues that there was excessive self - defense because the defendant suffered a concussion due to a blow to his head ( from the later victim ) and subsequently came into a these arguments of the defense do however not convince the court of appeal of the existence of a  strongly emotional mental state and increased vulnerability for excessive self - defense of the defendant at the time he hit the victim . another example concerns a defendant with brain damage , presumably due to prolonged abuse of alcohol and drugs . the defendant has inter alia memory problems , a low frustration tolerance and poor control of his emotions . the defendant is accused of manslaughter of a man after a fight between the two of them . the defense lawyer argues that the defendant used ( excessive ) self - defense due to physical and mental vulnerability and impaired impulse control in combination with the threatening situation . the defendant allegedly came into a state of reduced consciousness and would subsequently out of fear have acted impulsively . the court does not accept the reasoning of the defense lawyer because the court 's analysis of the subsequent events during the fight does not confirm the arguments of the defense . to summarize , in a few cases , we found information about assumed neurocognitive deficits of the defendant was brought up as mitigating information by the defense in the context of extra vulnerability to duress and ( excessive ) self - defense of the defendant . one reason for that appears to be that the claims that the defendant was extra vulnerable for a strong emotional state or ( excessive ) self - defense do not seem to be substantiated further by tests of mental capacities of the defendant or other evidence . as mentioned earlier , the majority of the cases found are cases in which neuroscientific information is introduced . behavioral genetic information is involved in 13 cases , and in another 10 cases neuroscientific information as well as behavioral genetic information is involved . in most of these cases , the only reference to  behavioral genetic information is a mentioning of the role of heritable factors in the etiology of mental disorders , such as schizophrenia or psychoses ( seven cases ) , autism spectrum disorders ( two cases ) , or personality disorder ( three cases ) . the experts in most of these cases ( usually a psychiatrist and psychologist ) use the information about heritable factors ( and other factors , such as problematic family conditions ) merely to explain how the disorder and the problematic behavior may have come about , and the court does not mention this information in its argumentation . nevertheless , there are also a number of cases in which the behavioral genetic information is used to help answer judicial questions . in one case , the defendant has a heritable neurological disorder , huntington 's disease , which is known to be caused by an aberrant gene on the fourth chromosome . the defendant is accused of setting fire to the house of his girlfriend , bringing the lives of several people into danger . huntinton 's disease is the cause of neuropsychological problems and dementia which make it difficult for him to deal with daily life and with problem situations . in such situations the defendant is considered completely unaccountable by the court for his crimes . however , the neuropsychological problems and their worsening because of the expected progression of the disease are likely to enhance the risk of criminal recidivism , according to the behavioral experts reporting to the court . therefore , the court orders that the defendant be committed to a psychiatric hospital , a measure that can be continued as long as the person is a risk to others . in this case , the genetic defect and the knowledge about its course and effects on the cognitive capacities and the behavior do not lead to any optimism by the experts about opportunities for reduction of criminal recidivism risk . addiction often runs within families , and genetic studies have shown that heritable factors account for 4060 per cent of the risk to develop an addiction . in six of the cases , we found , experts mention a heritable factor which makes the addicted defendant involved more inclined than an average person to develop substance dependence . in one of these cases , the psychiatrist reports that in developing alcohol dependence ,  a genetic factor via father and a contextual factor seem to have played a role. the psychiatrist considers the offense as mainly related to alcohol dependence , and states that the defendant is fully criminally responsible . the court , however , does not adopt the reasoning of the psychiatrist but argues that the  genetic component indicates that it can not be completely excluded that the defendant did not commit the offenses voluntarily ( reduced free will ) , and therefore the presence of criminal responsibility is questionable. in this case , the court uses the genetic component and its presumed consequences : limiting the behavioral choices of the defendant , as an argument to consider the defendant of diminished responsibility for his crimes . the reasoning in this case appears to be comparable to that of the court in a recent italian criminal case where the influence of the maoa - gene on aggressive behavior played a role . in the first case , a male who had been diagnosed with schizophrenia had stabbed another man to death . the defendant had not been taking his medication and was actively psychotic during the offense . he was found guilty by a first instance court and was given a reduced sentence of nine years because of his mental disorder . the court of appeal subsequently reduced the sentence to eight years based on the fact that the defendant tested positively for genetic variants that made him prone to aggression under stressful circumstances . several authors have criticized the basing of the judgment of criminal responsibility and the sentence ( partly ) on genetic characteristics of the defendant . , morse for instance argues that evidence of a causal relationship between a genetic variant and an elevated proneness to for instance impulsive aggression should not be equaled to an excusing condition . only if independent evidence would show that for instance the ability of the defendant to control strong emotions is compromised and that this influenced the offense , could there be an excusing condition . morse points out that an individual should not be judged on the basis of risk factors for developing a certain behavior , but on the basis of his mental capacities at the time of the offense . empirical findings nevertheless indicate that the latter can be closely related to genetic characteristics . in two cases , we found it is mentioned that pedophilia is inborn. in one of these cases , the defense lawyer states that the pedophile orientation of the defendant leads to strong emotions and a heavy pressure to view child pornography that is extremely hard for him to resist and that he should not be held responsible for . the defense lawyer also asks the question  whether a pedophile can be held morally responsible for his sexual orientation , when you realize that it originated from a genetic background and atypical brain development , citing a professor whose name is not mentioned in the case . the court , more in line with the reasoning by morse than the court in previous case , does not accept this argumentation and concludes that , although the defendant may not be held responsible for his pedophile orientation , this does not imply that he can not be held responsible for his pedophile actions : gathering and spreading child pornographic materials , and molesting a very young child . in addition , the court mentions that two behavioral experts report that the defendant has  normal abilities of impulse control. another context in which genetic factors are mentioned is that of personalized treatment . in one of the cases found is a particular gene ( maoa - gene ) mentioned in relation to treatment of aggressive behavior . this concerns the case of a tbs - patient who is detained in a so - called  long - stay unit within a forensic psychiatric detention center , a unit for patients who the center considers to have no perspective of successful treatment to reduce their risk of criminal recidivism . the patient has attacked three members of the staff with a pair of scissors that he had especially prepared for this goal . behavioral experts , a psychiatrist and a psychologist , report that the patient has severe antisocial and narcissistic personality disorder and cocaine dependence in remission . they consider aggression regulation a severe problem in this patient , with respect to reactive as well as instrumental aggression . the experts advise to place the patient in a high - security prison unit , since the tbs - treatment has led to no improvement . they also advise to investigate if in that setting the difficult to treat aggression regulation problems can be influenced pharmacologically . the psychiatrist is quoted saying :  if it appears that the patient has a reduced expression of the maoa - gene ( the so - called  warrior - gene ) a pharmacological treatment with depakine could be started. the court adopts the expert 's advice and sentences the patient to nine years imprisonment . depakine ( valproate ) is one of the most prescribed medications for epilepsy . because valproate has a mood- and impulse - stabilizing effect , it is also prescribed in some cases by psychiatrists to reduce aggressive behavior . researchers expect that subtyping of groups of addicted patients on the bases of genetic , neurobiological , and clinical variables will become more important for effective ( personalized ) treatment and risk assessment , which is also relevant for the judicial context . searching the years 200012 in the database of dutch case law on rechtspraak.nl yielded 231 criminal cases that met the selection criteria that neuroscientific or genetic information is introduced with respect to the suspect or defendant and in relation to behavior , brain function , or mental state . in the cases that were found , neuroscientific information is part of a more comprehensive examination of the mental capacities of the defendant . the neuroscientific information is typically one of the components of a larger picture , in addition to for instance psychiatric and psychological examinations and reports from the probation service . in the cases found , defendants inter alia suffer from diverse neurobiological phenomena : eg frontal dementia , addiction , epilepsy , and sleep disorder . mri , eeg , neuropsychological tests , and physiological sleep examination are techniques employed for gathering neuroscientific information in the cases found . in some cases , the role of neuroscientific information with respect to the decision of the court is quite large , for instance in the case where the defendant was considered of reduced accountability for his crimes partly on the bases of neurobiological information , or in the case the defendant was acquitted largely on the basis of physiological sleep assessment . in other cases , it is only small . neuroscientific information is introduced with respect to all of the judicial questions that are addressed in the dutch criminal trial and sentencing . a limitation is that our research is based on published cases and that we do not know whether they form a representative subset of all relevant cases ( including the unpublished ones ) . in the majority of the cases found , neuroscientific information is introduced as mitigating information in sentencing . in such cases , there is often a presumption that the defendant has a mental disorder or defective development that may have limited his responsibility for his criminal actions , and in which neurobiological aspects may play a role . although the information is considered as mitigating , it is mentioned in the literature that neuroscientific information may also function as a double edged sword. on the one hand , it may be considered mitigating information with respect to accountability , and may therefore contribute to the underpinning of a reduction of the sentence . on the other hand , neuroscientific information can contribute to the extent to which a defendant is perceived as a risk for society , for instance when neurobiological damage is perceived as untreatable . in the latter case , this may although the defendant can be considered diminished or not responsible for the crime , in practice lead to a longer sentence , such as a tbs - hospital order that can be periodically extended . some of our cases seem to confirm this line of reasoning ( such as the huntington 's disease case ) . however , others nuance it , for instance the cases of a stalker where the behavioral experts see room for improvement and reduction of recidivism risk , despite  untreatable neurobiological deficits that are assumed to contribute to recidivism risk . a difference with the huntington 's disease case is that in these latter cases the experts thought that the risk of threatening behavior was high , but the chance of direct personal violence was small . the  double edged sword - effect may be most prominent in cases with a high risk of severe violence . some of the ways neuroscientific information is used in criminal cases in other countries were not found in any dutch cases . this concerns for instance physiological  lie - detection or  fmri - lie detection. the scientific base for using these methods as evidence in court is considered too weak . in some cases in the usa , the involvement of information about the several criminal cases were found in which neurobiological or behavioral genetic aspects of addiction were discussed . however , in contrast to for instance canada , no cases were found in the netherlands with a defendant who was diagnosed with the fetal alcohol syndrome . although the number of cases is expected to grow by some ( see introduction ) , in only one of the dutch cases found , a candidate gene for aggression ( eg maoa - gene ) was mentioned in relation to medical treatment of impulsive aggression . in contrast to countries like italy , in none of the dutch cases found defendants appeared to have been tested for the mao - gene or other candidate genes . nevertheless , the impact of  heritable factors on the behavioral choices of the defendant is a question that is addressed in several of the cases found . clearly , the actors , behavioral as well as judicial , in criminal cases in the netherlands ask questions about what the implications of neuroscientific factors are for criminal responsibility , recidivism risk , or the best choice of treatment in the case of their defendant . the cases also show that views on the impact that neuroscientific information could or should have can be far apart , for instance in cases where the impact of genetic factors is an issue , or with respect to questions about criminal responsibility in relation to the impact of neurobiological damage in an addicted defendant . one area in which neuroscience may help to gain more insight is the impact of age , mental disorders , personality disorders , and addiction on the capacity to make decisions . neuropsychological tests and neuroimaging may provide objective measures for instance for attentional bias , impairments in self - control , and problems with decision - making in for instance addicted persons , and may in time help identify those addicts who have such severe problems with self - control or decision - making that they should be considered of diminished criminal responsibility . the development of guidelines and protocols for the use of neuroscientific information in criminal court ( as in physiological sleep disorder assessment ) may be advisable for other phenomena , such as pre - frontal brain damage , learning disabilities , or mental disorders such as schizophrenia as well . not only because they could serve to articulate the state of the knowledge and ways in which neuroscientific information can and can not be used , but also because they could be helpful to prevent biases to which neuroscientific evidence in the judicial context is vulnerable . an issue in the netherlands is that the pool of experts who report to the criminal courts about neuroscientific information is rather small . for instance , in the majority of cases in which neurological information was reported in relation to aggressive behavior , the same behavioral neurologist was consulted . for the growth of expertise in this area , it is important to have more professionals . the pool of neuropsychologists appears to be somewhat larger , since in the cases found , more different neuropsychologists reported . another important area for judicial practice is risk assessment . in several of our cases , a modest number of empirical studies are beginning to show how neuroscientific information can have an additive value for assessment of criminal recidivism risk . , , furthermore , research indicates that neurobiological factors may help predict who may and may not profit from cognitive behavioral treatment for antisocial behavior . although much is still unknown about the relation between neurobiological factors and behavioral choices , neurolaw is an area of research that offers chances to develop instruments to help answer judicial questions in criminal cases , that have an additive value with respect to practice as usual . to develop such instruments , practice oriented research is needed , as well as a dialog between researchers and legal practitioners .
in this contribution an empirical approach is used to gain more insight into the relationship between neuroscience and criminal law . 
 the focus is on case law in the netherlands . 
 neuroscientific information and techniques have found their way into the courts of the netherlands . 
 furthermore , following an italian case in which a mentally ill offender received a penalty reduction in part because of a 
 genetic vulnerability for impulsive aggression , the expectation was expressed that such 
 genetic defenses would appear in the netherlands too . to assess 
 how neuroscientific and behavioral genetic information are used in criminal justice practice in the netherlands , we systematically collect dutch criminal cases in which neuroscientific or behavioral genetic information is introduced . 
 data and case law examples are presented and discussed . 
 although cases are diverse , several themes appear , such as prefrontal brain damage in relation to criminal responsibility and recidivism risk , and divergent views of the implications of neurobiological knowledge about addiction for judging criminal responsibility . 
 whereas in the international  neurolaw literature the emphasis is often on imaging techniques , the dutch findings also illustrate the role of neuropsychological methods in criminal cases . 
 finally , there appears to be a clear need of practice oriented instruments and guidelines .