in cynomolgus macaques , which are widely used in drug metabolism studies , cyp2c19 
 ( formerly known as cyp2c75 ) is abundantly expressed in liver , metabolizes human cyp2c 
 substrates and is thus an important drug - metabolizing enzyme . 
 one of the cynomolgus 
 cyp2c19 alleles ( p.phe100asn , p.ala103val and p.ile112leu ) results in 
 substantially reduced metabolic activity and thus is an important allele in drug 
 metabolism studies . for this allele , a genotyping tool was developed using allele - specific 
 taqman probe . 
 genotyping 40 cambodian cynomolgus macaques using this tool found 1 
 homozygote , 17 heterozygotes and 22 wild type animals , and the result was confirmed by 
 direct - sequencing . 
 interestingly , this allele frequency was similar to that of chinese 
 cynomolgus macaques . 
 the genotyping tool established is useful for drug metabolism studies 
 using cynomolgus macaques .