radiation colitis is a well - recognized complication of radiation therapy for pelvic malignancies , which include prostate , endometrial , cervical or bladder cancers . late complications of pelvic radiotherapy consists of bleeding , anemia , strictures , fistula or anorectal dysfunction , and have an incidence rate of 520% . radiation - induced mucosal damage results in epithelial changes such as fibrosis , microvascular alterations , thrombosis , telangiectasia and endothelial degeneration [ 2 , 3 ] . patients often present with persistent rectal bleeding which may lead to iron deficiency anemia requiring blood transfusions . additionally , reduced distensibility of the rectum due to fibrosis may result in tenesmus and in some cases rectal stricturing leading to difficulty in defecation [ 1 , 4 ] . there have been numerous studies on the efficacy of argon plasma coagulation ( apc ) in the treatment of radiation proctitis . in contrast to conventional unipolar and bipolar electrocoagulation techniques , where adhesion of the probe to tissue and difficulty of assessing depth of thermal effect are major limitations , apc involves the delivery of unipolar diathermy current in a non - contact fashion , using the inert argon gas as the conducting medium . in a study by sebastian et al . , of 25 patients with persistent rectal bleeding and recurrent anemia , 81% achieved complete cessation of bleeding after a median of one treatment with apc ; no complications resulted from the use of this modality . other studies showed similar efficacies with potential complications such as rectal stricture   and recto - vaginal fistula . there have also been case reports of methane gas fire and colonic explosion when using apc . however , complete bowel preparation and a full colonoscopy prior to apc treatment will drastically reduce this risk . although the evidence is strong for apc in the management of radiation proctitis , there are currently little data on the treatment of radiation colitis . here we present two patients from the cross cancer institute and royal alexandra hospital in edmonton , alberta , in whom radiation colitis was successfully treated using apc . she had a total abdominal hysterectomy , bilateral salpingo - oophorectomy , bilateral pelvic node sampling , omentectomy and staging laparotomy 3 years prior to referral . pathology revealed grade 3 endometrial adenocarcinoma with heterogeneous serous papillary , undifferentiated and large cell neuroendocrine carcinoma elements . she completed a postoperative chemotherapy consisting of 4 cycles of intravenous carboplatin and etoposide at that time . unfortunately , 1 year later she developed recurrent undifferentiated endometrial carcinoma in the vaginal mucosa in the suburethral position . she received a course of salvage radical radiotherapy and was treated with a combination of 15 mv x - rays and 18 mev electrons with 4,500 cgy in 25 daily fractions to treat the perivaginal tissues , inguinal and pelvic lymph nodes . the residual perivaginal mass received a low dose rate interstitial brachytherapy boost of 2,535 cgy in 39 h. grade 4 rectal bleeding began 10 months after completion of radiation therapy . she had received a total of 44 units of packed red blood cells over 8 months and her hemoglobin ranged from 51 to 118 a colonoscopy performed 14 months prior to referral with small routine biopsies revealed fibrosis of the lamina propria , consistent with chronic radiation damage . an incomplete colonoscopy performed 5 months prior to referral revealed inflammation and bleeding from the anal canal up to 3540 cm proximally from the anal verge , consistent with radiation proctitis . after her referral to our clinic , a repeat colonoscopy revealed significant and diffuse sigmoiditis and proctitis up to 50 cm proximally from the anal verge ( fig . the apc generator was set to a flow of 2 l / min with a power setting of 40 w for sigmoid colon applications and a power setting of 60 w for rectal therapy . although she had experienced significant symptomatic improvement , rectal bleeding resumed 1 month post therapy , requiring 6 units of packed red blood cells transfusion over 2 months . a second procedure at 3 months revealed a significant reduction in the extent of colitis ( 30 cm ) compared to the initial assessment . 4050 applications of apc at 2 l / min and 60 w were performed with good hemostasis and tolerance by the patient ( fig . 1 ) . she did not require further blood transfusions for gastrointestinal bleeding after the second apc treatment . she had two subsequent sigmoidoscopies at 4 and 12 months after her last apc treatment which revealed excellent healing with no ulcers , strictures or fistulas ( fig . a 52-year - old female presented with a 3-month history of ongoing intermittent rectal bleeding and anemia requiring blood transfusion . she had a history of stage iib , grade 3 adenosquamous endometrial carcinoma that was treated with total abdominal hysterectomy , bilateral salpingo - oophorectomy and pelvic node dissection 2.5 years before . pathology at that time revealed direct tumor extension to the endocervix with myometrial invasion to within 1 mm of the serosa and multifocal lymphovascular space invasion . she underwent adjuvant postoperative external beam radiotherapy , consisting of 15 mv x - rays with a 4-field beam arrangement treating the pelvic lymph nodes , parametria and vaginal vault at a dose of 4,500 cgy in 25 daily fractions over 5.5 weeks . additionally , she received a high dose rate brachytherapy boost by a 3.5 cm diameter cylindrical vaginal applicator delivering a dose of 1,800 cgy in 3 daily fractions over 3 days . unfortunately , a 4.4  3.6 cm recurrent periurethral and perivaginal mass with pathology consistent with recurrence of grade 3 adenosquamous carcinoma of the endometrium was found 11 months later . this led to a salvage course of external beam radiotherapy consisting of 15 mv x - rays using a 3d conformal 4-field technique at a dose of 4,500 cgy in 25 daily fractions and low dose interstitial radiotherapy boost of 2,353 cgy in 47 h. the brachytherapy session was terminated prematurely due to an acute episode of dyspnea , fever and hypoxemia that was thought to result from a combination of atelectasis , narcotic - induced hypoventilation and possible urinary tract infection . in order to adequately treat her recurrence , a small portion of the rectal mucosa received an estimated cumulative dose of > 10,000 cgy . grade 4 rectal bleeding began 10 months after her last radiation therapy and her hemoglobin remained around 7585 g / l despite 7 units of packed red blood cells transfusion over 3 months . other significant medical history includes diabetes and coronary artery disease with a previous myocardial infarct event . colonoscopy revealed diffuse areas of telangiectasia consistent with severe radiation proctitis and sigmoiditis 15 cm proximal to the rectosigmoid junction . the apc generator gas flow was set to 2 l / min with a power of 60 w and 3040 applications were applied with good hemostasis and tolerance by the patient . after one apc treatment , her hemoglobin improved and remained stable at 90 g / l . at 3-month follow - up , she had significant reduction in telangiectasias ; however , due to the extent of the lesions , further apc at 60 w was applied . at 10 months , she had return of occasional bleeding per rectum and slight decrease in her hemoglobin , and a third colonoscopy with apc was performed . there was approximately 8 cm of mild colitis with a 2.5 cm ulcer that was 8 cm proximal to the anal verge . apc set to 2 l / min and 60 w was applied to 20 different areas with good hemostasis and tolerance by the patient . she received one unit of packed red blood cells 1 month after her third and last apc session . she did not require further blood transfusion for gastrointestinal bleeding and her hemoglobin was stable at 109 she developed rectovaginal fistula secondary to radiation therapy 3.5 years after her last apc treatment . radiation - induced enteropathy is a very common and disabling complication of pelvic radiotherapy in up to 10% of cases . it significantly decreases the quality of life of patients by interfering with the physical , psychological and social aspects of their lives . there are different medical therapies for radiation enteropathy , including steroids , antibiotics , antioxidants , sulfasalazine , short - chain fatty acids , sucralfate enemas and formalin instillation [ 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ] . although many single - center case series show evidence to support each of these medical interventions , endoscopic therapy allows for successful and immediate management of bleeding from radiation colitis . surgical management is reserved for cases of failed conservative treatments and is often associated with high morbidity and mortality [ 9 , 20 , 21 ] . despite the widely accepted use of apc in radiation proctitis [ 22 , 23 , 24 , 25 , 26 ] , there are few reports or studies on the use of apc in radiation colitis . in this report , we present two very successful cases in whom apc was used to manage radiation - induced colitis . both patients presented with chronic rectal bleeding and chronic anemia requiring multiple blood transfusions 10 months post radiation therapy . after treatment with apc , bleeding decreased significantly and , more important , transfusions were no longer required . the outcomes of apc treatments in these two cases have been assessed up to 3.5 years post therapy for both patients , and neither required further blood transfusions for gastrointestinal bleeding . it is also interesting to note that in case 1 , brachytherapy was placed into the anterior perivaginal tissues . with the insertion of a vaginal spacer physically displacing the posterior vaginal wall during treatment , therefore , case 1 may have an intrinsic or a genetic predisposition to late radiation injury . it is important to recognize that radiation colitis is common among patients with pelvic radiation , and our current management of many of these patients using conventional medical therapy is not adequate in achieving proper control of patients hemodynamics and their symptoms . the successful outcome of apc in the management of radiation colitis in our experience warrants the use of apc in similar cases . an assessment and comparison of this modality to other currently available treatments in larger - scale studies are needed . it is also important to compare the quality of life of patients between the different therapies in order to assess the effect of these treatments on their livelihood . our experience suggests that apc should be considered as first - line therapy when treating radiation colitis .
radiation colitis is a common consequence of pelvic radiation . 
 its complications may include anemia due to chronic bleeding requiring transfusions . 
 many of these patients are managed with rectal medications which are often inadequate for control . 
 argon plasma coagulation ( apc ) has been well described for its efficacy in treating radiation proctitis . here 
 we present two cases in whom apc therapy was used to treat severe radiation colitis . 
 we reviewed two cases originally seen at the regional cancer center ( cross cancer institute ) in edmonton , alberta , canada . 
 both patients received pelvic radiation for recurrent endometrial cancers and were referred for active bleeding secondary to radiation colitis that had required numerous transfusions . 
 radiation - induced telangiectasias were found from 1050 cm in the sigmoid colon . 
 both patients had significant improvement of symptoms after one session of apc treatment set at 4060 w and gas flow of 2.0 l / min . 
 there were no complications from the procedures . 
 neither patient required blood transfusions after the treatment with improvement in their hemoglobin levels and were doing well at 3- and 6-month follow - up . 
 apc can be used effectively to provide immediate and sustained resolution of symptoms in patients with radiation colitis .