phacomorphic angle closure is a secondary angle closure caused by a swollen and mature cataract obstructing the drainage angle , leading to an acute elevation of intraocular pressure ( iop ) and potential glaucomatous optic neuropathy ( gon ) if not treated timely . the initial aim of treatment of phacomorphic angle closure is to lower the iop with combinations of topical anti - glaucoma medications , systemic acetazolamide , intravenous mannitol and or argon laser iridoplasty ( alpi ) . all of these treatments have been established to be effective initial treatments with no evidence showing superiority of one over the other at the moment . the term phacomorphic glaucoma is used if there resultant gon   which has been previously quantified and reported using visual field ( vf ) assessments or clinical cup - disc ratio monitoring . however , both of these parameters are variable and not entirely objective especially when phacomorphic angle closure often affects an elderly population where dementia and neglect are common . in addition , studies in acute primary angle closure ( apac ) have shown that more than half of the patients with a single attack can have no visual field defects . on the other hand , retinal nerve fiber layer measurements can detect early gon as its damage often precedes visual field loss . the use of optical coherence tomography ( oct ) for retinal nerve fibre layer ( rnfl ) and optic nerve head analyses is non - invasive , requires minimal patient cooperation , and provides objective and early assessment of gon in patients with phacomorphic angle closure . consecutive cases of acute phacomorphic angle closure from december 2009 to december 2010 were recruited from caritas medical center , hong kong special administrative region , people s republic of china . the randomization was part of a treatment protocol of another study comparing the effects of initial treatments in phacomorphic angle closure . those receiving alpi received laser applications 360 to the peripheral iris with power titrated to achieve visualized contractions of the iris . those receiving systemic acetazolamide received intravenous acetazolamide 500  mg stat followed by oral acetazolamide 250  mg four times daily and slow - release potassium chloride tablets 600  mg twice daily if there were no systemic contraindications . all patients were put on the following eye drops : atropine 1  % daily ( alcon inc . , hnenberg , ch-6331 , switzerland ) , pred forte1% four times daily ( allergan inc . , irvine , ca 92623 - 9534 , usa ) , and timolol 0.5  % twice daily ( santen pharmaceutical co. ltd . , patients with presenting iop higher than 60  mmhg or iop higher than 40  mmhg after 2  h of treatment were given 200  ml of 20  % mannitol intravenously over 1  h. hourly iop was documented until it was below 25  mmhg . cases were included for consenting individuals with a first episode of acute ( < 14  days ) phacomorphic angle closure with an iop more than 40  mmhg . the diagnosis of phacomorphic angle closure was based on the presence of an intumescent cataract and signs of acute angle closure : conjunctival injection , shallow anterior chamber , corneal edema in the index eye or an open angle in the contralateral eye as determined by gonioscopy . cases were excluded if iop lowering treatment was given for this acute episode prior to the study or where alpi was not possible either due to a severely edematous cornea or uncooperative patient . all cases received extracapsular cataract extraction ( ecce ) and intraocular lens ( iol ) insertion under regional anesthesia by one of the three glaucoma surgeons at our center within 3  days of presentation to our clinic . ecce was chosen over phacoemulsification due to less endothelial damage from ultrasound energy and phacoemulsification would impose greater surgical risk in the setting of phacomorphic angle closure especially in the presence of any residual corneal edema and zonule loosening . patients were followed up on day one , 1  week , 1  month , 3  months and as needed postoperatively and iop was measured by goldman applanation tonometry in each visit . best corrected visual acuity ( bcva ) was measured by snellen chart at 1  month postoperatively . the trabecular - iris angle was measured by gonioscopy and ultrasound biomicroscopy ( ubm ) at 3 months post attack . stratus optical coherence tomography ( carl zeiss meditec inc . , dublin , ca , usa ) was used for rnfl in micrometers ( m ) and vertical cup - disc ratio ( vcdr ) measurements in both eyes at 3 and 9  months post phacomorphic attack . the pupils were pharmacologically dilated to at least 5  mm prior to oct and all scans were performed using fast scan mode by a single operator ( jl ) with 4  years of operating experience . all scans had centered alignment and signal strength of six or more , suboptimal scans were repeated . multiple scans ( two to four per eye ) were obtained per secession and the scan with the highest quality ( highest signal strength and most centred alignment ) was selected . visual field was assessed at 9  months post cataract extraction with the humphrey field analyzer ( carl zeiss ophthalmic systems , inc . , dublin , ca , usa ) using swedish interactive threshold algorithm fast ( sita fast ) , 24 - 2 strategy . paired wilcoxon matched pairs ( signed rank ) test was used to compare the rnfl in the following settings : between the eye with phacomorphic angle closure and the contralateral ( non - attack ) eyes at 3  months.between the eye with phacomorphic angle closure at 3 and 9  months.between the contralateral eye at 3 and 9  months . between the eye with phacomorphic angle closure and the contralateral ( non - attack ) eyes at 3  months . between the eye with phacomorphic angle closure at 3 and 9  months . between the contralateral eye at 3 and 9  months . for the above tests , the four quadrants and average thickness were compared independently in a planned comparison basis . mann whitney u test was used to compare the rnfl and vcdr between eye with phacomorphic angle closure and contralateral eye as well as to compare the pattern standard deviation ( psd ) on the vf between the two eyes . pearson s correlation was used to determine correlation between rnfl and psd . for all statistical calculations p  <  0.05 was considered significant and all means were presented as mean    standard deviation . paired wilcoxon matched pairs ( signed rank ) test was used to compare the rnfl in the following settings : between the eye with phacomorphic angle closure and the contralateral ( non - attack ) eyes at 3  months.between the eye with phacomorphic angle closure at 3 and 9  months.between the contralateral eye at 3 and 9  months . between the eye with phacomorphic angle closure and the contralateral ( non - attack ) eyes at 3  months . between the eye with phacomorphic angle closure at 3 and 9  months . between the contralateral eye at 3 and 9  months . for the above tests , the four quadrants and average thickness were compared independently in a planned comparison basis . mann whitney u test was used to compare the rnfl and vcdr between eye with phacomorphic angle closure and contralateral eye as well as to compare the pattern standard deviation ( psd ) on the vf between the two eyes . pearson s correlation was used to determine correlation between rnfl and psd . for all statistical calculations p  <  0.05 was considered significant and all means were presented as mean    standard deviation . eleven consecutive cases of acute phacomorphic angle closure presented to our center during the study period . four cases received alpi and six cases received systemic acetazolamide as the initial means of control iop . all iop s were lowered to < 25  mmhg within 5  h of treatment with corneal clarity achieved day one after treatment . two cases received intravenous mannitol because one presented with iop more than 60  mmhg and the other had persistent iop > 40  mmhg 2  h after treatment with systemic acetazolamide . all cases received ecce  +  iol within 3  days of presentation to our center . one case required scleral fixation of the iol due to postoperative posterior chamber iol subluxation 1  week after the initial operation . for the ten cases , the mean age was 79.1    8.3  years . the mean time taken from phacomorphic symptoms to ophthalmic consultation was 2.1    2.8  days ( range : 0.510  days ) . the postoperative iop at 3  months was 10.5    3.4  mmhg without any glaucoma medication . at 9  months post operation , the mean iop was 11.0    3.1  mmhg ; all except one patient required topical glaucoma medications for iop control the bcva postoperative va was 0.4    0.2 , including a case was a pre - existing atrophic macula that had a presenting va of lp and a postoperative va of 0.1 . there was no significant difference between the vcdr as measured by oct in the attack ( 0.6    0.2 ) and contralateral eye ( 0.6    0.1 ) ( p  =  0.4 ) . at 3  months post attack , there was no significant difference between the average rnfl of the eye with phacomorphic angle closure ( 95.1    21.5  m ) and the contralateral eyes ( 105.9    27.8  m ) analyses of each of the individual quadrants again showed no difference between the two eyes ( all p  >  0.2 ) . however , at 9  months post attack , the average rnfl of the phacomorphic eye had progressive thinning from 95.1    21.5  m at 3  months to 85.4    21.0  m at 9  months ( p  =  0.01 ) . quadrant analyses showed significant thinning in the superior ( 110.5    32.74 to 95.9    30.6  m , p  =  0.01 ) and inferior quadrants ( 117.8    30.7 to 90.60    25.5  m , p  =  0.006 ) but there was no significant progressive thinning in the nasal ( p  =  0.6 ) or temporal ( p  =  1.0 ) quadrants ( tables  1 , 2).table  1rnfl thickness ( m ) of the phacomorphic eye versus contralateral eye at 3  months post attackphacomorphic eyecontralateral eyep valuesuperior quadrant110.5    32.7121.5    34.60.6nasal quadrant71.1    24.978.7    24.70.3inferior quadrant117.8    30.4132.9    23.30.2temporal quadrant76.3    19.573.1    14.41.0average thickness94.4    22.6102.6    20.31.0table  2rnfl thickness ( m ) in the phacomorphic and contralateral eyes at 3 versus 9  months post attackcontralateral eye at 3  monthscontralateral eye at 9  monthsp valuephacomorphic eye at 3  monthsphacomorphic eye at 9  monthsp valuesuperior quadrant121.5    34.6115.8    28.70.2110.5    32.795.9 30.70.01*nasal quadrant78.7    20.776.7    15.80.571.1    24.974.0    20.20.6inferior quadrant132.9    23.1114.5    31.20.4117.8    30.790.6    25.50.006*temporal quadrant73.1    14.491.9    37.40.376.3    19.580.7    34.01.0average thickness102.6    20.399.76    17.80.194.4    22.685.4    21.00.01 * *  statistically significant ( p  <  0.05 ) rnfl thickness ( m ) of the phacomorphic eye versus contralateral eye at 3  months post attack rnfl thickness ( m ) in the phacomorphic and contralateral eyes at 3 versus 9  months post attack *  statistically significant ( p  <  0.05 ) for the contralateral eye , there was no significant difference in the average rnfl ( p  =  0.1 ) nor individual quadrants from 3 to 9  months ( all p  >  0.2 ) . the other cases had poor fixation , unreliable parameters or defaulted the appointment . the mean deviation ( md ) was 5.8    3.7  decibels ( db ) and the psd was 4.2    3.0  db . there was no significant difference in the psd between the attack ( 4.2    3.0  db ) and contralateral eye ( 3.1    1.1  db ) ( p  =  0.7 ) . there was also no significant correlation between the rnfl thickness on oct and the psd on vf ( p  =  0.2 ) . in the literature , oct for rnfl has been used to evaluate the damage after a single episode of acute primary angle closure and to offer a more objective supplement to the information provided by humphrey visual field assessments . to the best of our knowledge , this is the first prospective clinical trial using oct to investigate rnfl thickness and vcdr in phacomorphic angle closure . have found a linear relationship between a longer duration of attack and a poorer va . ramakrishanan et al .   found that 70  % of their phacomorphic glaucoma patients had final bcva of 20/40 when the duration of symptoms was < 10  days . similarly , prajna et al .   found that 61  % of their phacomorphic patients had final visual acuity of 6/12 or better but that a glaucomatous process for more than 5  days was associated with poorer visual outcome . our study was consistent with these finding in that our patients had a final mean bcva of 0.4    0.2 ; their mean phacomorphic symptom duration was 2  days and all received definitive cataract extraction within 3  days of presentation , resulting in a mean duration of phacomorphic angle closure of < 5  days . we have demonstrated that despite the definitive removal of the intumescent cataract , glaucomatous optic neuropathy was an ongoing progress that took place between 3 and 9  months after the initial attack . there was no significant rnfl difference between the phacomorphic and contralateral eye at 3  months but a significant thinning of the average , superior and inferior rnfl was observed at 9  months post attack in the eye with previous phacomorphic angle closure . the contralateral eye , on the other hand , showed no interval differences in the average or quadrant rnfl thicknesses . studies involving apac have used scanning laser polarimetry to demonstrate that rnfl can be thinned after the attack [ 7 , 8 ] . but no study to date can determine the rate of rfnl thinning after an episode of apac [ 9 , 10 ] . aung et al .   has found that rnfl can decrease from anywhere between 2 and 16  weeks after a primary angle closure attack . similarly , tsai et al .   found no significant difference in rnfl thinning between 4 and 12  weeks post apac but significant differences between 1 and 4 , and 1 and 12  weeks . in fact , they found that the rnfl was thicker at 1  week in the eye with apac compared the contralateral eye followed by a rapid thinning by 4  weeks , likely due to an initial optic nerve edema . one may argue that the progressive rnfl thinning in primary acute angle closure may not all be attributed to the acute rise in iop as this group of patients will have had narrow drainage angles for a certain duration and the rnfl thinning may represent damage from previous intermittent angle closures or a chronic angle closure in evolution . on the other hand , in phacomorphic angle closure , the pathology is in the sudden anterior bulging of the swollen cataract , thus , intermittent or asymptomatic chronic angle closure is less likely than in apac . thus , the gon that allows a phacomorphic attack is possibly mainly attributed to the acute iop rise . yoles and schwartz   have suggested that gon progression can occur even after elimination of the acute rise in iop as a result of secondary apoptosis of healthy neurons bathed in the degenerative milieu created by the damaged neurons from the acute event . the other possibility for gon progression is a secondary angle closure that develops after the phacomorphic attack but all our cases had iop  <  21  mmhg during follow - up and the mean iop at 9  months was 11.0    3.1  mmhg with open angle configurations on ubm . therefore , we are more inclined with the postulation that the initial optic nerve hypoperfusion from the phacomorphic attack induced cellular inflammatory cytokines and free radicals that led to progressive ganglion cell damage even after the initial phacomorphic angle closure resolved . it is also possible that there can be some initial optic nerve edema post attack that gradually subsides with time giving the impression of a pseudo - thinning  but our first oct was performed quite some time after the initial attack , at 3  months post operation , and by comparison with the contralateral eye , there was no significant difference in thickness , making this possibility less likely . our study involving secondary angle closure reports rnfl thinning between 3 and 9  months post attack and our follow - up oct is one of the longest reported in literature for acute angle closure . regarding the use of vf in the assessment post phacomorphic angle closure , a number of patients lacked the coordination to produce a reliable vf . furthermore , the results produced at 9  months post attack failed to demonstrate any significant difference between the phacomorphic and contralateral eye but there was already significant rnfl thinning detected on oct . there was also no correlation between the psd on vf and the degree of rnfl thinning on oct . first , the assumption was made that both eyes had similar initial rnfl thickness and vcdr prior to the phacomorphic attack when using the contralateral eye as a proxy of the pre - phacomorphic state . this was because all of the cases presented to our center for the first time during the attack without any prior clinical data . it is possible that the documented rnfl thinning may be due to an underling normal tension glaucoma per se , therefore , in addition to comparing with the other eye , we also compared the progression of rnfl thinning in contralateral eye as well at 39  months and only found progression in the attack eye but not in the contralateral eye . second , both alpi and medical treatment was used to lower iop but there is no evidence in the literature to support superiority of one treatment over the other and all iop s were lowered to 25  mmhg within 5  h of presentation . our study further supports this evidence that the initial iop lowering technique was not related to outcomes . in our prospective case series , patients with < 5  days duration of phacomorphic angle closure had a mean snellen vision of 0.4 . an acute episode of phacomorphic angle closure can trigger an accelerated thinning of the average rnfl occurring between 3 and 9  months post phacomorphic attack despite normal iop and open angles . the rnfl thinning was most prevalent in the superior and inferior quadrants as detected by oct whilst visual field assessment failed to detect any significant differences between the attack and uninvolved eye .
to investigate the retinal nerve fibre layer ( rnfl ) changes after an acute attack of phacomorphic angle closure . 
 this prospective study involved ten cases of phacomorphic angle closure that underwent cataract extraction and intraocular lens insertion after intraocular pressure lowering . 
 apart from visual acuity and intraocular pressure ( iop ) , rnfl thickness and vertical cup disc ratio ( vcdr ) were measured by optical coherence tomography ( oct ) at 39  months post attack . 
 humphrey visual field assessment was performed at 9  months post attack . 
 all cases had mean phacomorphic duration of < 5  days . 
 postoperatively , best correct snellen visual acuity was 0.4    0.2 and iop at 9  months was 11.0    3.1  mmhg . 
 there was no difference in vcdr and rnfl between the attack and contralateral eye at 3  months post attack ( both p  =  0.4 ) . at 9  months 
 post attack , there was significant thinning in the average ( p  =  0.01 ) , superior ( p  =  0.01 ) , and inferior ( p  =  0.006 ) rnfl . 
 there was no significant difference in the pattern standard deviation ( psd ) between the two eyes on the humphrey visual field nor was there any correlation between psd severity and rnfl thinning ( all p  >  0.2 . 
 patients with < 5  days duration of phacomorphic angle closure are likely to have reasonable postoperative vision . 
 an acute episode of phacomorphic angle closure can trigger an accelerated rnfl thinning despite normal iop and open angles , most noticeable in the superior and inferior quadrants , occurring between 3 and 9  months post attack . 
 glaucomatous optic neuropathy in the attack eye was evident by oct but not by visual field assessment at the same time interval .