the term myeloid hyperplasia has been used interchangeably with many other terms to describe an increased production of granulocytes , megakaryocytes , and erythrocytes in the spleen and other organs in the mouse . 
 this process is occasionally misdiagnosed as granulocytic leukemia . 
 this paper reviews some of the terms used interchangeably with myeloid hyperplasia and describes criteria that can be used to differentiate myeloid hyperplasia from granulocytic leukemia . 
 additionally , the results of a study in which myeloid hyperplasia was induced following the formation of skin tumors in sencar mice is discussed . in this study , positive correlations were found between skin lesions , the spleen weight , and histologic appearance of the spleen . 
 the liver rarely showed microscopic changes of myeloid hyperplasia unless the spleen weighed at least 1.0% of the body weight.imagesfigure 3.figure 4.figure 5.figure 6.figure 7.figure 8.figure 9 .