despite diagnostic and therapeutic improvements , cardiogenic shock ( cs ) is still the most common cause of death in patients with acute myocardial infarction . although percutaneous coronary intervention ( pci ) , inotropes , fluids , adjunctive medication , intra - aortic balloon pump ( iabp ) , and ventricular assist devices are widely available therefore , munsterman and colleagues , whose investigation of the microcirculation in patients with iabp was reported in the previous issue of critical care , have addressed an important topic . in the last five years , an important body of knowledge showing the pathophysiological importance of the microcirculation in the development of multiple organ failure in critically ill patients has been built up . this has been made possible because of the development of novel techniques to either directly visualize or indirectly evaluate microvascular perfusion . in cs , microvascular alterations have been observed , resulting in a decrease of vessel density , the proportion of perfused capillaries , or microvascular flow . different treatment strategies , including pharmacological interventions and mechanical assist devices , may lead to microcirculatory improvement in cs [ 5 - 7 ] . in their article , munsterman and colleagues show that in patients deemed ready for discontinuing iabp support , microcirculatory flow in small vessels increases after ceasing iabp therapy . these important findings not only highlight the need for optimal timing of weaning from iabp support but also demonstrate that global hemodynamics do not necessarily result in changes of microvascular perfusion . in theory although sufficient cardiac output and arterial pressure are prerequisites for adequate microvascular perfusion , their relationship is very complex . changes in microvascular vessel density and flow , their heterogeneity , autoregulation , and response to therapeutic interventions might be dissociated from systemic effects . furthermore , with the knowledge of the study by munsterman and colleagues , it is obviously important to realize that , depending on the stage of the disease course , an intervention has different effects on the microcirculation . modern therapy of cs consists of an adequate regime with revascularization , drug treatment , and mechanical support . although there is no question about the survival advantage of early revascularization and its beneficial consequences for the macrocirculation , there is no systematic study on its effects on microcirculation . however , revascularization reverses the spiral of progressive left ventricular dysfunction and therefore is understood to improve the microcirculation . different drugs , particularly fluids , vasopressors , inotropes , levosimendan , and vasodilators , influence the hemodynamics of patients with cs . the administration of fluids in cs is based mainly on pathophysiological considerations and has not been studied in adequate randomized clinical trials . no data regarding fluid administration and microcirculatory changes in the setting of cs are available . similar to fluid administration , the choice of vasopressor and inotropic therapy is based mainly on individual experience and institutional policy ; furthermore , this choice differs between guidelines . however , vasopressors might be able to stabilize the mean arterial pressure , but their use has negative consequences for the perfusion within microvasculature . in small observatory studies , beneficial effects on microcirculatory indices in cs have been described for levosimendan and nitroglycerin . owing to the lack of evidence for the use of iabp in cs after successful revascularisation of occluded infarct vessels , its role remains controversial . to date , there is no adequately powered randomized clinical trial available , and knowledge is based on observational trials or trials before the era of primary pci . iabp support improves microvascular flow in unstable patients ; however , different time points of the disease seem to be of importance . guiding inter - individual modern therapy of cs with in vivo visualization tools may allow a more specific and appropriate therapy regime and improve outcomes . more effort is needed to understand the microcirculation as a therapy target and not as a silent bystander . effect of treatment strategies on microcirculation : solid arrow , positive effect ; dotted arrow , negative effect . cs : cardiogenic shock ; iabp : intra - aortic balloon pump ; pci : percutaneous coronary intervention .
despite diagnostic and therapeutic improvements , mortality rates in patients with cardiogenic shock remain relatively high . 
 several studies showed that cardiogenic shock is associated with alterations in the microvascular circulation . 
 these alterations may be reversed by extracorporeal support devices . 
 a study by munsterman and colleagues adds to the body of evidence showing that in patients deemed ready for discontinuing intra - aortic balloon pump ( iabp ) support , microcirculatory flow in small vessels increases after ceasing iabp therapy . 
 this study not only highlights the need for optimal timing of weaning from iabp support but also supports recent findings that global hemodynamics do not necessarily result in changes of microvascular perfusion . 
 all modalities of modern treatment in cardiogenic shock need to be evaluated for their effect on the microcirculation . 
 microcirculatory evaluations should be part of randomized controlled trial protocols . 
 more effort is needed to improve outcomes and understand the microcirculation as a therapy target and not as a silent bystander .