the velopharyngeal sphincter ( vps ) is a muscle belt located between the oropharynx and the nasopharynx and includes the muscles of the soft palate ( anterior wall of the vps ) and the lateral and posterior pharyngeal walls . the vps comprises the levator veli palatini , tensor veli palatini , muscle of uvula , superior pharyngeal constrictor , palatopharingeus , palatoglossus , and salpingopharyngeus1 . among these muscles , those of the soft palate , especially the tensor veli palatine , have an important role in the physiological function of the region . while the vps is not a sphincter by strict definition ( a circular muscle band in a hollow viscera ) , its physiological function is that of a sphincter , as it works like a valve , contracting and occluding itself2 . the vps plays an extremely important role in allowing alternation between the respiratory and digestive paths of the pharynx during swallowing3 . velopharyngeal closure , performed by the vps , is essential in motor actions of the region such as speaking , whistling , blowing , sucking , and swallowing4 . several studies have described inter - subject variability in velopharyngeal closure1 
 5 and have identified 4 types of closure based on structure movement6 
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 1 
 5 . in the coronal type of closure , there is more participation of the soft palate . sagittal closure predominantly involves the lateral pharyngeal walls . in the circular type of closure , finally , the circular type closure with a passavant ridge , is similar to the circular closure except that a passavant ridge is present on the posterior pharyngeal wall . the raising of the soft palate and , concomitantly , the medial approximation of the lateral pharyngeal walls promotes the partial or complete separation of the nasal and oral portions of the pharynx . the velopharyngeal structures are thus important for the production of speech , as they distribute and direct airflow to the oral cavity to produce oral sounds and to the nasal cavity for the emission of nasal sounds1 
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 9 . investigators have several types of tools to choose from when assessing vps function10 
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 12 . a detailed description of the velopharyngeal mechanism was obtained only after the availability of both direct and indirect assessment methods . direct methods enable the investigator to visualize the structures involved in velopharyngeal closure and to observe how these structures move during different types of motor actions . indirect methods provide information on the functional repercussions of velopharyngeal action13 
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 14 . videonasoendoscopy is one of the most widely used methods for studying velopharyngeal function , allowing visualization of the nasal , pharyngeal , and laryngeal cavities . using dynamic images directly from the anatomical structures15 , this method has multiple applications , including diagnosis , prognosis , and postoperative follow up11 . this test can be used to observe the pattern of closure even during speech , which involves wide variations in velum and pharyngeal wall motion . videonasoendoscopy can also be used to identify the presence of the gap corresponding to the residual orifice during maximum contraction of the vps16 
 17 . as a counterpart to the use of more sophisticated tools for velopharyngeal assessment , clinical judgment by means of hearing using this method , the investigator can assess a subject 's oral communication performance and determine the extent of speech impairments related to resonance18 
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 21 . impaired velopharyngeal closure prevents separation of the oral and nasal cavities during the production of oral phonemes , exposing the nasal cavity to the entry of unexpected air flow . this impairment in velopharyngeal closure , known as velopharyngeal dysfunction ( vpd ) , can be congenital , as with cleft lip . there is a widespread consensus among researchers and healthcare professionals that the surgical and clinical findings of subjects with cleft lip / palate should be based on an auditory - perceptual evaluation and at least one instrument - based evaluation of velopharyngeal function13 
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 24 . the use of both assessment modalities is highly valuable and widely used in clinical practice , as the findings of one method complement the other . despite this common practice , there are few studies comparing patient evaluations using videonasoendoscopy ( clinical estimation of gap size ) and auditory - perceptual assessments ( hypernasality ) . this study aimed to determine whether the findings of videonasoendoscopy in patients with cleft lip / palate are associated with demographic features , clinical factors , or the findings of auditory - perceptual assessments . this retrospective , cross - sectional study assessed 49 individuals , of both genders , with cleft lip / palate who were followed up at the otorhinolaryngology service and at the speech therapy outpatient clinic of hospital de clnicas de porto alegre ( hcpa ) . the study was approved by the hcpa research ethics committee under protocol number 10 - 0490 . the population consisted of individuals follow up at the hcpa in the plastic surgery service , craniofacial surgery outpatient clinic ; otorhinolaryngology and at the  speechtherapy and craniofacial malformations  outpatient clinic . this assessment was carried out by a speech therapist with more than 10 years of experience in the area . the inclusion criterion was assessment by speech therapy screening and videonasoendoscopy between september 2011 and august 2012 . we excluded from the study patients with blurred videonasoendoscopy images and those with excess secretion from the nasal cavity or missing data . the speech therapy screening assessed the following auditory - perceptual parameters : resonance , presence , and severity of hyponasality and hypernasality ( mild , moderate , severe)25 ; speech disorders , identified as compensatory ( such as glottal stops ) or obligatory ( weak intraoral pressure , facial mimicry , audible nasal air emission , nasal snoring ) . for analysis purposes , hypernasality and its severity the speech therapist used a speech sample comprising 2 sentences with phonetic predominance of oral plosive phonemes / p/ (  papai pediu pipoca  ) and fricative phonemes / s/ (  o saci sabe assobiar  the patients also performed a segment of continuous speech , counting from 1 to 10 . using videonasoendoscopy , we analyzed the portion of the test related to the sustained emission of the /s/ phoneme , chosen because it leads to complete closure of the vps , thereby minimizing misinterpretations due to interference by the production of another phoneme . the evaluators made a clinical estimation of the vps gap size using an adapted version of a protocol described in previous studies10 
 27 . the vps gap size was classified according to the following scale : 1 , no gap ( complete velopharyngeal closure ) ; 0.80.9 , small gap ( efficient closure ) ; 0.40.7 , moderate gap ( intermediate closure ) ; 0.10.3 large gap ( inefficient closure ) ; 0 , very large gap ( lack of closure ) . this protocol assessed the following : presence or absence of adenoids contributing to velopharyngeal closure ; presence or absence of mobility of the palate and lateral and posterior pharyngeal walls ; vfs closure type ( coronal , sagittal , circular , or circular with passavant ridge ) . the pearson 's chi - square test was used to evaluate the association between videonasoendoscopy and perceptual - hearing evaluation . the mcnemar 's test was applied to assess the differences between evaluators , and the kappa coefficient was applied to assess inter - evaluator agreement . whitney test ( quantitative variables with asymmetric distribution ) , and pearson 's chi - square and fisher 's exact tests ( categorical variables ) were applied to investigate the association between clinical factors and examination methods . the criterion for including a variable in the model was a p value  <  0.10 in the bivariate analysis . analyses were performed using spss ( statistical package for the social sciences ) version 17.0 . the median age at the time of evaluation was 11 years , with the majority of the cohort between 9 and 16 years . the most common cleft type was the left unilateral complete cleft ( 30.6% , n  =  15 ) , followed by bilateral complete cleft lip / palate ( 28.6% , n  =  14 ) , right unilateral ( 20.4% , n  =  10 ) , cleft palate ( 14.3% , n  =  7 ) , and submucosal cleft ( 6.1  % , n  =  3 ) . secondary palatoplasty was performed in only 4.1% of the subjects , at a median age of 18.5 years . table 1 shows the results from the speech therapy screening , including the assessment of resonance as well as compensatory and obligatory articulation disorders . we found that 77.6% of the subjects presented with hypernasality , which was moderately severe in 36.7% and mildly severe in 28.6% of these subjects . as illustrated in table 1 , articulation disorders were found in 81.6% of subjects , 75.5% of whom had obligatory disorders and 57.1% of whom had compensatory disorder ( glottal stops ) . the most frequently observed obligatory disorder was weak intraoral pressure , which was present in 75.7% of the subjects . * multiple - choice question inter - evaluator comparison of the findings of the videonasoendoscopy , as well as comparison of these test results with those of the auditory - perceptual evaluation was assessed using the emission of the /s/ phoneme . the inter - rater agreement was established using the kappa agreement coefficient , matching the findings of one rater with those of the other . in this study , the fleiss ' kappa agreement coefficients28 were interpreted as previously reported29 : < 0.00 , no agreement ; 0.000.20 , poor agreement ; 0.210.40 , fair agreement ; 0.410.60 , moderate agreement ; 0.610.80 , substantial agreement ; and 0.811.00 , perfect ( or almost perfect ) agreement . an almost perfect agreement ( kappa of 0.831.00 ) was observed regarding the contribution of adenoids in velopharyngeal closure , mobility of pharyngeal walls , predominant type of movement , closure type , and vps gap size during emission of the /s/ phoneme . one evaluator 's results indicated that 20.4% of the subjects had no vps gap , 40.8% had a small gap , 16.3% had a moderate gap , and 22.4% had a large gap . demographic data indicated that the subjects with more severe velopharyngeal closure impairment underwent later primary palatoplasty ; the presence of a moderate to large gap was significantly associated with an age at primary palatoplasty of over 23 months . all individuals requiring secondary palatoplasty ( n  =  2 ) showed impairment in velopharyngeal closure , although this result was not statistically significant . there were no other statistically significant associations between variables . we compared the vps gap size as estimated by clinical and auditory - perceptual assessments ( table 2 ) . we also investigated the relationship between the gap size and both the severity of hypernasality and the presence of speech disorders ( compensatory and obligatory disorders ) . * multiple choice question ; * * statistically significant association by the test of residuals adjusted to a 5% of significance level . our results indicate that more severe impairment of velopharyngeal closure was observed more often in subjects with moderate / severe hypernasality , with statistical significance for severe hypernasality ( p  =  0.021 ) . in addition , we found severe hypernasality was significantly associated with the presence of other speech disorders ( p  =  0.035 ) , whether compensatory and/or obligatory , increasing the likelihood of having a moderate to large gap ( intermediate to inefficient velopharyngeal closure ) . ten subjects ( 20.4% ) showed discrepant results with regard to velopharyngeal function , having moderate / severe hypernasality  +  other speech disorders together with complete and efficient gap closure . conversely , 6 subjects ( 12.2% ) had intermediate / inefficient closure with no moderate / severe hypernasality . these discrepant findings may be due to the differences in the analytical parameters ( speech and continuous sound emission ) , although both parameters involve velopharyngeal function . the auditory - perceptual evaluation assessed a larger speech sample ( counting of numbers and 2 sentences focusing on /s/ and /p/ phonemes ) . the instrumental evaluation observed the sustained emission of the /s/ phoneme , which provides maximum vps contraction . in such cases that present physical evidence of closure but indicate abnormal resonance , it is very important for the interdisciplinary team to re - evaluate the findings to perform a differential diagnosis of velopharyngeal dysfunction . therefore , it can be inferred that the maintenance of motor action in speech is not consistent . few of these investigations have considered the following factors in the same study : ( 1 ) protocols for clinical and instrument - based assessments recommended in the literature , including a detailed description of the criteria used for analysis of the variables under study ; ( 2 ) inter - evaluator agreement for assessments using videonasoendoscopy ; ( 3 ) the possible variables interfering with velopharyngeal closure ( participation of adenoids and speech therapy treatment for velopharyngeal occlusion ) . these speech anomalies are of interest to researchers who investigate speech production in individuals with cleft lip / palate32 
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 25 . a recently study26 has emphasized that obligatory disorders should receive attention from a structural point of view and not only from the perspective of velopharyngeal function ; the identification of velopharyngeal dysfunction can help to establish whether speech therapy intervention is indicated for individuals with cleft lip / palate . the auditory - perceptual evaluation used in the present study took these structural features of obligatory disorders into account . hypernasality was reported in 77.6% of our subjects , the severity of which was moderate in 36.7% and mild in 28.6% . speech disorders were identified in 89.8% of the subjects , of whom 87.8% had obligatory disorders and 57.1% compensatory disorder ( glottis stop ) . one of the most frequent obligatory disorders was weak intraoral pressure , present in 75.7% of the subjects . our findings corroborate those in the literature reporting a higher occurrence of weak intraoral pressure , hypernasality , and glottis stop37 
 4 
 37 . the results of this study thus suggest that the weak intra - oral pressure caused by vpd produces audible nasal air emission and hypernasality in speech . in turn , glottis stops may occur as a consequence of poor articulation habits learned in childhood that do not necessarily reflect physical or neuromuscular changes38 . we believe that the high occurrence of hypernasality and other articulation disorders in our cohort is related to their referrals from speech therapy , indicating that they had an issue involving oral communication . although these patients were followed up for a longer time by the hcpa interdisciplinary team that provides a variety of services , a speech therapy outpatient clinic linked to universidade federal do rio grande do sul was added in 2011 to treat patients with cleft lip / palate . before the creation of this outpatient clinic , the patients were treated just by a speech therapist from hcpa , with a period of care limited to one shift for this population . as it constitutes a curricular internship , in which undergraduate and graduate students practice the activity , the response to this demand is still limited . reports in the literature point out that experience is crucial in both the conduction and analysis of the videonasoendoscopy test . accordingly , we assessed the inter - evaluator agreement with regard to gap size in the emission of the /s/ phoneme , observing that it was almost perfect ( kappa , 0.830.95 ) . this result also illustrates that the criteria adopted for interpreting the findings were very homogeneous between the raters . these findings corroborate those described in other scientific studies using this protocol10 , indicating that the data are in accordance with the proposed objective39 
 40 
 41 . we observed that 20.4% of the subjects did not have a vps gap ; 40.8% had a small gap , 16.3% had a moderate gap , and 22.4% had a large gap . thus the predominant velopharyngeal closure type was coronal ( 69.4% , n  =  34 ) which has greater mobility of the anterior wall of the vps corresponding to the soft palate . the prevalence of the sagittal type was 24.5%12 , and the circular type was 6.1%3 . studies have demonstrated that the coronal pattern is also the most frequent among individuals without cleft lip / palate42 
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 7 , but individuals with cleft palate tend to have a broader distribution between the other patterns of closure43 
 7 
 44 . among the associations related to demographic and clinical data , only age at the time of primary palatoplasty our findings indicate that the later primary palatoplasty is performed the greater the compromise in velopharyngeal closure ( moderate to large gap size ) , with a significant associated with ages above 23 months ( p  =  0.016 ) . however , when analyzing the variables independently associated with intermediate / inefficient velopharyngeal closure ( by controlling confounding factors ) , age at primary palatoplasty was not significantly associated but was near the threshold ( pr  =  1.01 ; 95% ci , 1.001.02 ; p  =  0.088 ) . the trend in the data indicates that every additional month until the performance of the first palatoplasty leads to a 2% increase in the prevalence of inefficient closure . the author of a previous study46 proposes that the appropriate time for surgical repair of the palate is 1218 months of age , taking into account maxillary growth and velopharyngeal function . one report on the association between various clinical factors and velopharyngeal closure in cleft lip / palate found that velopharyngeal closure was higher among individuals with deciduous dentition than among those with mixed or permanent dentition47 . the present study aimed to compare the findings of auditory - perceptual evaluation and those of videonasoendoscopy . our data indicate that subjects with more compromised velopharyngeal closure have a higher incidence of moderate and severe hypernasality , showing that both tests indicated the compromise in velopharyngeal function . a statistically significant association was found between severe hypernasality ( p  =  0.021 ) and intermediate / inefficient closure with a gap size ranging from moderate to large . we found one study that aimed to evaluate auditory - perceptual assessment , but the authors adopted a different classification system for the findings of videonasoendoscopy and did not relate them to the efficiency of velopharyngeal closure . a retrospective study investigated the relationship between the auditory - perceptual characteristics of speech and velopharyngeal gap size20 , and the authors concluded that information regarding velopharyngeal gap size can be predicted from speech assessment alone . confidence in the prediction was stronger when the patient had moderate to severe hypernasality , which was more commonly associated with a large gap . we found a statistically significant interaction ( p  =  0.035 ) of the severity of hypernasality and the presence of other articulation disorders with the clinical estimate of vps gap size . the interaction of both changes identified in the auditory - perceptual evaluation increased the likelihood of the presence of a moderate to large gap . multivariate analysis confirmed this association ( pr  =  1.26 ; 95% ci : 1.031.54 ; p  =  0.026 ) . this result is observed in the clinical practice , as the presence of hypernasality is usually associated with at least one articulation change , whether obligatory or compensatory . the articulation changes associated with hypernasality reflect the difficulty in acquiring and maintaining velopharyngeal closure47 . to gain a better understanding of these cases , we investigated velopharyngeal physiology during the motor action related to speech . first , 10 subjects ( 20.4% ) had complete / efficient velopharyngeal closure but also had moderate / severe hypernasality . second , 6 subjects ( 12.2% ) had intermediate / inefficient closure with no moderate / severe hypernasality . although both videonasoendoscopy and auditory - perceptual evaluation assess velopharyngeal function , this study used different samples and speech extensions . the videonasoendoscopy analyzed only the sustained emission of the /s/ phoneme , using a comfortable intensity for the patient that was audible for the examiner . this phoneme was chosen because its emission requires the action of all velopharyngeal walls and their maximum contraction to achieve complete velopharyngeal closure . this information allows the examiner to identify the presence or absence of a vps gap . the observation that some patients have unsatisfactory findings in the auditory - perceptual evaluation and good findings in videonasoendoscopy suggests that resonance in continuous speech is unaffected . hypernasality is often associated with the length of time required for vps opening and not directly with the degree of opening or even with the air flow that escapes from the nasal cavity48 . for example , patients with adequate velopharyngeal closure as assessed by instrument - based assessment may have hypernasality because of the abnormalities in the temporal spectrum of velopharyngeal closure . the great physiological variability of the vps may be related to factors such as speed of speech , characteristics of isolate phoneme emission , and association of different phonemes ( consonant - vowel)1 . this variability may account for the patients who have intermediate / inefficient closure but no moderate / severe hypernasality . further factors may explain this versatility in velopharyngeal closure as follows : the action of several muscles associated with the levator veli palatini ( palatoglossus , palatopharingeus , and superior pharyngeal constrictor ) ; mechanical factors , especially the position of the tongue in the oral cavity ; and the specific phonological rules of each linguistic system49 
 5 . in summary , we recommend that patients with discrepant results between evaluations and those with unsatisfactory results should be referred to interdisciplinary clinical evaluations to determine the best course of action.26 . emphasizes that obligatory and compensatory articulation disorders affect speech , and that obligatory disorders should receive attention from both the structural and functional points of view26 . it was found that our patient cohort had a high prevalence of hypernasality and compensatory and articulation disorders . in addition , we observed a high frequency of individuals with a small gap , and a predominance of the coronal type closure . the individuals with more severe velopharyngeal closure impairment underwent late palatoplasty , although this comparison did not remain significant after adjustment by the multivariate model . comparison of the 2 evaluation methods showed that subjects with moderate / severe hypernasality had more severely impaired velopharyngeal closure . hypernasality is more closely associated with clinical estimation of gap size than are other obligatory and compensatory disorders . the interaction between hypernasality severity and the presence of other disorders increases the likelihood of having a gap ranging from moderate to large . although we found cases with discrepancies between the findings of the auditory - perceptual and instrument - based evaluations , we observed an association between the findings of these 2 evaluation methods .
summary 
 introduction :  the velopharyngeal sphincter ( vps ) is a muscle belt located between the oropharynx and the nasopharynx . 
 investigations of velopharyngeal function should include an auditory - perceptual evaluation and at least 1 instrument - based evaluation such as videonasoendoscopy . 
 aim :  to compare the findings of auditory - perceptual evaluation ( hypernasality ) and videonasoendoscopy ( gap size ) in individuals with cleft lip / palate . 
 method :  this was a retrospective , cross - sectional study assessing 49 subjects , of both sexes , with cleft lip / palate followed up at the otorhinolaryngology service and the speech therapy outpatient clinic of hospital de clnicas de porto alegre ( hcpa ) . 
 the results from the auditory - perceptual evaluation and the videonasoendoscopy test were compared with respect to the vps gap size . 
 results :  subjects with moderate / severe hypernasality had more severe velopharyngeal closure impairment than those with a less severe condition . the interaction between hypernasality severity and the presence of other speech disorders ( p  =  0.035 ) , whether compensatory and/or obligatory , increased the likelihood of having a moderate - to - large gap in the velopharyngeal closure . 
 conclusions :  we observed an association between the findings of these 2 evaluation methods .