@ prop ##ano ##l and tri ##fl ##uo ##ro ##eth ##ano ##l as solvent . the first chi ##ral lewis acid promoted as ##ym ##metric na ##zar ##ov cy ##cl ##ization was reported by var ##ind ##er ag ##gar ##wal and utilized copper ( ii ) bis ##ox ##az ##olin ##e ligand complexes with up to 98 % ee . the en ##ant ##iom ##eric excess was unaffected by use of 50 mo ##l % of the copper complex but the yield was significantly decreased . = = related reactions = = extensions of the na ##zar ##ov cy ##cl ##ization are generally also sub ##sume ##d under the same name . for example , an α @ - @ β , γ @ - @ δ un
@ propanol and trifluoroethanol as solvent. the first chiral lewis acid promoted asymmetric nazarov cyclization was reported by varinder aggarwal and utilized copper ( ii ) bisoxazoline ligand complexes with up to 98 % ee. the enantiomeric excess was unaffected by use of 50 mol % of the copper complex but the yield was significantly decreased. = = related reactions = = extensions of the nazarov cyclization are generally also subsumed under the same name. for example, an α @ - @ β, γ @ - @ δ un