elimination of the benz ##yl alcohol moi ##ety , so that the resulting stereo ##chemist ##ry of the newly formed ring arises from approach of the si ##ly ##l al ##ken ##e anti to the ether . = = = polar ##ization = = = drawing on the sub ##sti ##tu ##ent effects compiled over various trials of the reaction , professor alison frontier of the university of rochester developed a paradigm for " polar ##ized " na ##zar ##ov cy ##cl ##izations in which electron dona ##ting and electron withdrawing groups are used to improve the overall select ##ivity of the reaction . creation of an effective vinyl nu ##cle ##op ##hil ##e and vinyl electro ##phile in the substrate allows catalytic activation with copper tri ##fl
elimination of the benzyl alcohol moiety, so that the resulting stereochemistry of the newly formed ring arises from approach of the silyl alkene anti to the ether. = = = polarization = = = drawing on the substituent effects compiled over various trials of the reaction, professor alison frontier of the university of rochester developed a paradigm for " polarized " nazarov cyclizations in which electron donating and electron withdrawing groups are used to improve the overall selectivity of the reaction. creation of an effective vinyl nucleophile and vinyl electrophile in the substrate allows catalytic activation with copper trifl