##tones that marked the first major examination of this process . na ##zar ##ov correctly reasoned that the ally ##lic ole ##fin iso ##mer ##ized in situ to form a di ##vin ##yl ke ##tone before ring closure to the cy ##cl ##open ##ten ##one product . the reaction shown below involves an al ##ky ##ne ox ##yme ##rc ##uration reaction to generate the re ##quisite ke ##tone . research involving the reaction was relatively quiet in subsequent years , until in the mid @ - @ 1980s when several synth ##eses employing the na ##zar ##ov cy ##cl ##ization were published . shown below are key steps in the synth ##eses of tri ##cho ##die ##ne and nor @ - @ ste ##re ##pol ##ide , the
##tones that marked the first major examination of this process. nazarov correctly reasoned that the allylic olefin isomerized in situ to form a divinyl ketone before ring closure to the cyclopentenone product. the reaction shown below involves an alkyne oxymercuration reaction to generate the requisite ketone. research involving the reaction was relatively quiet in subsequent years, until in the mid @ - @ 1980s when several syntheses employing the nazarov cyclization were published. shown below are key steps in the syntheses of trichodiene and nor @ - @ sterepolide, the