lewis acids have been sub ##sume ##d under the name na ##zar ##ov cy ##cl ##ization provided that they follow a similar me ##chan ##istic pathway . the success of the na ##zar ##ov cy ##cl ##ization as a tool in organic synthesis stems from the utility and u ##bi ##qui ##ty of cy ##cl ##open ##ten ##ones as both motifs in natural products ( including ja ##smo ##ne , the afl ##ato ##xin ##s , and a sub ##class of pro ##sta ##gl ##and ##ins ) and as useful synthetic intermediate ##s for total synthesis . the reaction has been used in several total synth ##eses and several reviews have been published . = = mechanism = = the mechanism of the classical na ##zar ##ov cy
lewis acids have been subsumed under the name nazarov cyclization provided that they follow a similar mechanistic pathway. the success of the nazarov cyclization as a tool in organic synthesis stems from the utility and ubiquity of cyclopentenones as both motifs in natural products ( including jasmone, the aflatoxins, and a subclass of prostaglandins ) and as useful synthetic intermediates for total synthesis. the reaction has been used in several total syntheses and several reviews have been published. = = mechanism = = the mechanism of the classical nazarov cy