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Life in Sam's Box: New Planner!
With back-to-school just around the corner for us in Spain, I thought I'd share my new planner for this year. You can see the planner from last year here.
I usually take my time when picking a daily planner but then always end up with the same brand: Finocam. Finocam to Spain is like Filofax to everywhere else, but they do one-year-throw-as-you-go planners as well. That's the one I've chosen for this year.
When I'm choosing a planner I prefer a week-at-a-glance format and a nice cover. The problem is the prettiest ones are usually a larger size than what I'm looking for. I like my planner to fit nicely into any of my bags, especially the one I usually take to class. This year, however, I've nailed it! Yes, sir, because this year I bought a planner with an empty cover! You heard me, my favourite sized planner with a customizable front page. Want to take a peek?
I just found a blue chevron print online and added the year and my name at the bottom on Excel. I am delighted with the result. Here are a few close ups:
The fonts I've used are:
I also added a photo of my lurrrve on the back of the front page (the photo paper also gives the front page more strengh and is now unlikely to crease) and a couple of post-it blocks on the first page, like so:
Since I went a bit colour-coding mad last year (more on this subject further on), I use different colours in my planner for different tasks, such as:
So there you have it! My new 2013-2014 daily planner!
Have you got your new planner yet? Do you prefer your planner to start in September or in January? Are you digging chevron as much as I am? Please share your opinion in the comments below!
Note: I do not know what is going on with my photos, they seem to lose a lot of quality when I edit and upload them. I'll try to get the problem fixed a.s.a.p.
Etiquetas: organizing, planners, Sam, school, study
Jenny September 4, 2013 at 11:21 PM
I own a Filofax planner and it's amazing. I really recommend them if you're looking for a good planner. I also color code everything and have a clean plastic pencil pouch with different colored pens in the front of it.
Sam de Jesus September 5, 2013 at 1:59 PM
I'd love to buy a Filofax. I've been looking for a Metropolitan Lavendar planner but I'm not sure what size yet. And they aren't cheap either. Thanks for the comment!

value: Blogger is an American online content management system (CMS) which enables multi-user blogs with time-stamped entries. Pyra Labs developed it before being acquired by Google in 2003.


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Amazon.com: Customer Reviews: Solar Power Your Home For Dummies
5.0 out of 5 stars What a Resource this is!!!!
We are finally building our home overlooking a small vineyard we've designed and now are bound to it.....just like a baby, can't take it back, you know? Okay, Solar Power Your Home has been a fantastic primary source guide book. Full of clear understanding and guidance...my husband is fascinated by solar energy! Good start to put us on our way! thanks.
Published 21 months ago by Claire Cashman
1.0 out of 5 stars Solar Power Your Home
The title of this book is misleading to the buyer. I was thinking the contents had to do with actually placing solar panels, batteries, etc. to convert sunlight to power. There was very, very little of this. Book is mainly basics of home energy conservation, finance, very wordy and boring.
Published on December 3, 2011 by ogg
1.0 out of 5 stars Solar Power Your Home, December 3, 2011
By ogg - See all my reviews
2.0 out of 5 stars Good book for energy conservation - very LITTLE on solar, April 20, 2011
I was specifically looking for some information for configuring/sizing a solar system for my home. This book had a lot of good energy conservation suggestions; however, there was little to no information about configuring/sizing, or really any other information for someone to build a solar system themselves. Perhaps my bad, but I had thought of these "__________ for Dummies" books tailored toward the do-it-yourself-ers. That is not the case here. They focus on giving you suggestions for questions to ask contractors, but little details on the technical aspects of the system the contractor may, or might not install.
1.0 out of 5 stars Not so "illuminating"..., February 1, 2010
By A. Blandon "fivezerofive" (Nicaragua) - See all my reviews
I regret having purchased this book... I should've spent a bit more money and gotten a more comprehensive guide to Solar Power. Someone could argue it's for beginners but it left me wanting more... A book about alternative energy systems should be more detail oriented.
2.0 out of 5 stars Not at all informative about solar power., June 8, 2013
This review is from: Solar Power Your Home For Dummies (Kindle Edition)
Mostly told me I was to dumb to install a system by my self, only talks about yard lights and stuff. When it gets technical it just tells you to hire a "profesional.
3.0 out of 5 stars Looking deeper helps., July 27, 2010
By Barry Johnston - See all my reviews
A great book as far as it goes, but working for a solar supplier (PV and thermal) here is one area which probably merits deeper exploration. This is the answer to the old chestnut question, which is: "How long does it take before I reach energy payback on my solar installation". While this is often addressed where the baseline is money, for a green technology the environmental baseline is at least as important. Our research suggests that the answer is:PV installations - 5-7 years.Complex solar thermal systems (low carbon mains electric pumps) - over 4 years.Zero carbon, simple solar thermal systems (thermosyphon or PV pumped such as Solartwin) - 2 years or less.The risk is that the "techno-bling" or "eco-bling" appeal of complex technologies can sometimes outsmart the environmental appeal of simpler technologies. Or insulating. Or using less heat in the first place!
2.0 out of 5 stars Blah. Blah Blah, October 6, 2013
If your'e looking to go off grid, skip this one. Redundant common knowledge about home energy conservation. No "meat on the bone" hands on details here, mostly common knowledge. I read through half of it hoping it was going somewhere.... It didn't.
1.0 out of 5 stars Bad book, August 16, 2013
By cphoto - See all my reviews
I really would rate this book -4stars if possible. The information is basicallyworthless and there are a lot of blank pages and blank or blacked out spaces on about.30percent of the pages. I would not recommend it.
2.0 out of 5 stars There"s A Better Book, December 2, 2013
By bill moss "bill moss" (usa) - See all my reviews
If you want information about how to apply solar power to your home don't buy this book... Rather, choose the better dummies book, Photovoltaic Design & Installation. Whether you have advanced knowledge or a beginner just thinking about if it would be practical for you, the book by Ryan Mayfield is your best source by far.. The book begins with basic electricity and uses easy to understand wording to explain every detail about how to build and connect a solar panel system. His book explains components in detail and the differences in material choices... And if you are just thinking about solar, Ryan Mayfields book offers positioning and space requirements, expense considerations, and diagrams of how all the parts work together. System efficiency, effects of temperature, and reasonable expectations are easily understood in the mayfield book: Photovoltaic Design & Installation for Dummies.
1.0 out of 5 stars Waste of money, December 2, 2013
By A. Judge "Old Man" (Georgia) - See all my reviews
Waste of money. Read the internet and save yourself the purchase price. Not even good as a fire starter. word
2.0 out of 5 stars Not what I expected, June 17, 2013
By A. Cole (TX) - See all my reviews
This book is more about Hot Water and things not related to what I considered worthwhileI was looking for more on solar electricdisappointed
Solar Power Your Home For Dummies by Rik DeGunther (Paperback - January 19, 2010)

type: global

value: Amazon.com, Inc. ( AM-ə-zon) is an American multinational conglomerate which focuses on e-commerce, cloud computing, digital streaming, and artificial intelligence.


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Beautiful little cottage. - Review of RAILWAYMAN'S COTTAGE, 1860s terraced cottage, woodburner, enclosed courtyard, Northmoor Green, England - TripAdvisor
Beautiful little cottage. - RAILWAYMAN'S COTTAGE, 1860s terraced cottage, woodburner, enclosed courtyard

value: Tripadvisor, Inc. is an American online travel company that operates a website and mobile app with user-generated content and a comparison shopping website.


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Kachuss Delights: Coconut & Chana Dal Filling for snacks
Posted by Hasna Hamza Layin at 10:47
Shaami (Shajitha Habeeb) 11 June 2015 at 11:57
Very useful post, especially for beginners..
Hasna Hamza Layin 20 June 2015 at 14:02
Thanks Shaami
Rafeeda AR 11 June 2015 at 13:39
You put Ramadan instead of Sha'aban dear... :) Lovely filling...
haha...thank u for pointing that out :) edited ..
Nammi 11 June 2015 at 21:01
interesting post, thanks for the link on time management
Hasna Hamza Layin 20 June 2015 at 14:03
remya sean 12 June 2015 at 13:18


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What's the company culture at Johnson & Johnson? - Johnson & Johnson Jobs | Indeed.com
What's the company culture at Johnson & Johnson?
Every business has it's own style. What is the office environment and culture like at Johnson & Johnson?Are people dressed in business casual, jeans and t-shirts, or full-on suits? Do folks get together for Friday happy hours and friendly get-togethers?What is a typical day in the life of an employee at Johnson & Johnson?
The culture is suppression and depression, do as your told don't make waves. Ignore FDA and OSHA (never enough money to fix problems) If you want to come home frustrated and depressed, feeling like anything you do will never be good enough to get ahead with this company... Then purse it.. The job I found this post site with is my old job and the posters here are telling it like it is, They might as well shred their precious CREDO because the company has become so dilute with other organizations and managements So many young managers from the "Me" generation, that the CREDO setup by General Johnson is now one big sheild that the corporation can hide behind. I consistanly brought up issues concerning FDA violations, Cgmp policies, and OSHA violations... Still managed to hang onto my job until at a supposed confidential meeting regarding "THE CREDO" I bought up UNION REPRESENTATION as a way to improve the working conditions and the relationship with HR, 3 weeks later I was suspended for one week due to time reporting issues and then terminated the following week. Funny how that worked out since my coworker had been warned repeatedly for years about attendance issues is still working there and I had never recieve a warning about attendance or time reporting (a case can be built against anyone). This company does not care about the employee... I held a position in a lab and was given a chance on a 1 yr. assignment as a scheduler before the year was up they filled my old job forcing me to stay in scheduling. Then moved into bio-formulation, While there a Teamleaders position opened up once there found out they considered it a lateral move and recieved no compensation for taking on the responsiblility of 16 - 20 people at the time. Back to formulation... Made a Tech II but my wages overlapped so there was no increase for the promotion after 19yrs. 6month and 25 days they fired me for attendance reporting problems, 3 weeks after I said UNION REPRESENTATION.
I have worked for multiple J&J companies in the past. They have all been amazing opportunities with fun and challenging work environments. Opportunities to lead and take on more responsibility were always abundant. I have never had such a rewarding job in the past.
CDTL THROMBOSIS EARLY DEVELOPMENT Job Spring House, PA
Scientist, Immuno-Oncology Discovery Job Spring House, PA
Global Regulatory Leader – Immunology Job Spring House, PA
Raritan, NJ (100)
Spring House, PA (85)
Skillman, NJ (60)

value: Indeed is an American worldwide employment website for job listings launched in November 2004. It is a subsidiary of Japan's Recruit Co.


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PHILANTHROPY 2173: Whole new capital markets
That is what Forbes has noted about Good Capital and xigi. Check out the xigi post here and the full Forbes story (registration required) here.
4/06/2007 12:56:00 PM
yes, and what is it that i meant by that? well, who knows. it was hours of talking with a reporter. the story was quite good at one time. then an editor with a fixation on tax intruded and dropped out a lot of why it was that people would actually buy this new premise, that there is an asset class between giving and investing. curiously, it has become today the top story on forbes.com and been wrapped into a four story package including a commentary on how leftists are penetrating the legacies left in their foundations by robber barrons. also included is a quixotic social enterprise funded by a rich divorcee out of her property settlement. obviously, the curmodgeons of status quo capital are adding their own unique context to our intrusion into their playpen.
Do you have a list of similar firms? I've wanted to about blog about it myself, but haven't searched for other VC firms and only know of the Acumen Fund. My boyfriend is a VC, but also not as familiar with the newer, more socially responsible firms.
Ashley - Check out xigi.net - that's where the whole sector is mapping itself
I entirely agree with Kevin that there must be a change in the traditional methods of getting capital out to social ventures but I am not entirely sure that ensuring financial return is the best method for ensuring a social return (it should go on the record that here at AIDG we create for profit small manufacturing facilities entirely to see magnified and sustained social returns). I am a big fan of New Profit’s combination of social return and financial return but even this fails to capture some of the needs. The concern is that, from the outside, New Profit and other similar Orgs seem to play a straight numbers game. Not spending money commensurate with the earning power of the individual impacted seems risky for a NFP in these situations. I was at the Partners in Health annual Tom White Symposium a couple of months ago watching Jim Kim speak. He spoke of how they developed their success, the answer was learning through mistakes, mistakes funded by Tom White. I worry that if funders trend towards requiring return you won’t have innovators like Farmer spending 15-20 grand a patient to cure people in Peru for MDR TB and developing DOTS plus. Perhaps not a big deal if you don’t think of the consequences of removing that source of what is essentially R&D for the poor. I hope funder desires for returns don’t prevent NFPs from posting such losses if it can help their constituencies. After all the primary goal of the NFP and the funder is in the end to actually help change a social ill.


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Soil survey of the Westerville area, Ohio, by J.E. Lapham and Charles N. Mooney (Instance) - Indiana State Library
The instance Soil survey of the Westerville area, Ohio, by J.E. Lapham and Charles N. Mooney represents a material embodiment of a distinct intellectual or artistic creation found in Indiana State Library.
https://evergreen.lib.in.us/opac/extras/ac/jacket/large/r/19928640
Context of Soil survey of the Westerville area, Ohio, by J.E. Lapham and Charles N. Mooney

 Data from Soil survey of the Westerville area, Ohio, by J.E. Lapham and Charles N. Mooney - Indiana State Library

Data Citation of the Instance Soil survey of the Westerville area, Ohio, by J.E. Lapham and Charles N. Mooney
http://link.library.in.gov/resource/o59Jc6syCss/
http://library.link/resource/o59Jc6syCss/

value: A library is a collection of materials, books or media that are easily accessible for use and not just for display purposes. It is responsible for housing updated information in order to meet the user's needs on a daily basis.


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TripAdvisor | Ilha Grande Day Trip from Rio de Janeiro provided by Nattrip | State of Rio de Janeiro
Ilha Grande Day Trip from Rio de Janeiro provided by Nattrip
Get picked up in the morning from your Rio de Janeiro hotel in the city’s downtown and southern tourist zones, after which you’ll drive around two hours to reach Brazil’s “Costa Verde” region.
You’ll arrive in the port city of Angra dos Reis and board a boat to begin your exploration of this coastal paradise. Spend the rest of the day enjoying the sun-drenched tropical vibes of the Bay’s collection of more than 300 offshore islands. Stop by Ilha Grande, the most famous of the bunch, to enjoy its crystal-clear waters and postcard-perfect beaches.
Then visit Ilha de Cataguases, known for its unique topography, and stop by Lagoa Azul, known to be one of the finest diving locations in the region. Many underwater explorers report the area is home to a variety of starfish, squid, colorful fish, and coral. The trip will make two additional stops in Freguesia de Santana, an island with an agricultural history that dates back to colonial times, and Praia de Japariz, another isle known for its scenic beaches.
At the end of your trip you’ll return to share and transfer back to your hotel in Rio de Janeiro.
Note: Our operation does NOT support Hotels in Barra da Tijuca, Recreio, São Conrado and Santa Tereza)
Boat tour Angra dos Reis and Ilha Grande
Drinks, available for purchase
It is recommended that you bring a light snack, water, sunscreen, and insect repellent
manjunior007, Manager at Nattrip, responded to this reviewResponded August 8, 2019
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The Cupel Recruits by Susan L. Willshire, Paperback | Barnes & Noble®
by Susan L. WillshireSusan L. Willshire
The Cupel Recruits by Susan L. Willshire
WOULD YOU BE RECRUITED?
A cupel is a dish used in alchemy for separating lead from gold. How would you separate and recruit an elite team from the rest if the fate of the world was in your hands? Expert physicists have done just that in this tale of ten recruits who clutch their grasp on reality as surprising twists and turns continue right to the end.
Unknowingly followed and monitored for years prior, the team is counted upon in ways they cannot fully understand. Once at the training compound, a rigorous training schedule and extensive indoctrination program quickly become their new way of life. With every turn as the ground shifts beneath them, all they thought they knew is just a shred of the truth. Not told of their mission, shock radiates when it is revealed that they must fix an error by the leaders of a world-wide experiment that has endangered the entire planet of Earth. One woman, left behind, must still lead a dangerous mission in the jungles of Africa, and unknowingly still has a role to play in the fates of... the Cupel Recruits.
Reminiscent of classic science fiction, but with modern-day action, new theories in almost every area of science will surely engage philosophical individuals who like to think their way through a book. What is reality?
9780615397368
Willshire Atheneum

value: Barnes & Noble Booksellers is an American bookseller. It is a Fortune 1000 company and the bookseller with the largest number of retail outlets in the United States.


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March | 2007 | The EcoLibertarian
Even in great big Canada, we might not have enough room
A Library of Parliament report on biofuels douses some cold water on the idea that Canada could produce enough ethanol for our own transportation needs:
Global production is still too small and the need for raw materials is still too high for biofuels to have a significant impact on the fuel market and be able to compete with fossil fuels.
The energy yield from ethanol or biodiesel depends on the feedstock used. For instance, one hectare (ha) of sugarcane grown in Brazil produces almost twice as much ethanol as the same area of corn grown in Canada. It would take slightly less than 2 ha of wheat or 0.6 ha of corn grown in Canada to run a car entirely on biofuel for one year,(3) while 0.3 ha of sugarcane grown in Brazil would provide enough biofuel for the same level of consumption.
By using 16% of its total corn production in 2006, the United States replaced 3% of its annual fuel consumption with biofuels. According to Agriculture and Agri-Food Canada (AAFC), if 100% of the total U.S. corn production were used, that figure would rise to 20%.
According to an article in the New Scientist, Canada would have to use 36% of its farmland to produce enough biofuels to replace 10% of the fuel currently used for transportation. Brazil, by contrast, would need to use only 3% of its agricultural land to attain the same result.
The Canadian Renewable Fuels Association disputes all this figuring, but you’d expect it to. It’s likewise worth noting that the CRFA’s executive director, Kory Teneycke, is a former adviser to Mike Harris and Preston Manning, according to his CRFA bio, and its “press secretary” is Phil von Finckenstein, a former press aide to Stockwell Day. None of which means anything by itself, of course, but there are more connections between the biofuels industry and Canada’s governing Conservatives than a mutual love of corn.
Posted in agriculture, ethanol	Charging polluters in the Port of Vancouver
Starting April 1, ships that meet a gold standard of emission controls will pay $0.057 per gross registered tonne [to put in at the Port of Vancouver], down from the previous fee of $0.077. Ships without any discount will see their fees rise to $0.097 per GRT. Ships that can attain a silver or bronze ranking will be charged $0.067 and $0.077 per GRT respectively.
“The differentiated rates … are designed to provide a wide variety of technology and fuel options to vessels in order to promote and build awareness around a number of alternative emission reduction practices,” the Vancouver Port Authority said in a news release. “The gold air emission standard is at a level that will be attained by leading-edge vessels, while the bronze standard is designed to be achievable by many vessels that currently call in the Port of Vancouver.”
The Sun reports that the difference between the gold standard and no standard could be about $2,600 for a typical container ship, and quotes a shipping-industry spokesman saying he doesn’t expect the incentive to shape up will be enormous, but it might provide a critical extra push for companies that already considering upgrading their vessels.
This is an obvious and smart move for the Port Authority, a federal institution with a lot of autonomy. Pollution from vessels docking in Vancouver is a major issue in the Lower Mainland, and one federal regulators can’t do a whole lot about, given the international (indeed, in an era when landlocked countries can have shipping registries, practically a-national) character of the shipping industry. But Vancouver’s a very desirable port, and it can certainly say hey, if you want to use our facilities, you have to pay up for the pollution you leave behind.
Dropping the fees for ships that meet the higher standard is particularly important — they deserve a reward, at the same time as slackers are being punished.
Photo from the Vancouver Port Authority website.
Posted in fossil fuels, trade	Economic thinking about the environment
Posted in economics, public policy	Should we pay for land protection?
Posted in agriculture, conservation, property rights, public policy	Prince Charles’s “hypocrisy” on the environment
This is London has twin stories about the flying habits of two well-known guys: John Travolta and Prince Charles. Both fly quite a bit (Travolta actually pilots himself, and lives in a house where he can park planes as though they were cars), and the both say that people should live less polluting and wasteful lives. This is London suggests their words might not be wholly compatible with their deeds.
On Travolta:
“I’m probably not the best candidate to ask about global warming because I fly jets.
“I use them as a business tool though, as others do. I think it’s part of this industry – otherwise I couldn’t be here doing this and I wouldn’t be here now.”
According to a recent study by the government-funded Carbon Trust, this means he boasts a carbon “footprint” nearly 100 times that of the average Briton, who is responsible for 10.92 tons of Co2, from his flights alone.
It’s not clear how Travolta came to say these things. Probably somebody asked him about them, since the mag says he talked about this on the red carpet at the U.K. premiere of his new movie, and he answered off the top of his head. Seems to me that saying “hey, people should fly less even though I acknowledge I fly a lot myself” is better than saying “hey, I’m rich and I can do what I want, so screw the rest of you.”
The case of Charles is more problematic. This is London jerks him around for flying from London to Scotland when he could have taken a train or something, but concedes that Camilla has recently had a hysterectomy and was flying with a nurse on board, so I’m prepared to forgive him that. Maybe they shouldn’t have gone to Scotland at all under the circumstances, but I won’t lose any sleep.
There is a more interesting case, though:
Charles vowed last December to “substantially” curb his reliance on gas-guzzling transport in favour of scheduled flights and train travel.
And a month later he turned down a private jet and took 20 members of his staff business class on a British Airways jet to New York to collect an award marking his environmental awareness.
In his speech, Charles said climate change “was a war we simply have to win”. And he was applauded when he added: “It is surely the duty of each and every one of us to find out what we can do to make the situation better.”
Nonetheless green campaigners and Environment Minister David Miliband said he could have accepted the award by video link.
Hmmm. The BBC says that the award was only one event in a tour that took the Prince of Wales to New York City and Philadelphia for two or three days, and was undertaken with the approval of the Foreign Office. They did royal things — visiting schools and charities, attending a major musical performance, giving out awards themselves. The prince visited Independence Hall in Philadelphia, a reasonably major deal for the heir to the British crown if you look at it on the grand scale of history (though admittedly Edward VII visited when he was the prince of Wales in 1860, when I suppose it was a really major deal). A lot of Americans presumably came away from their encounters with him, however distant they were, liking Britain just a little bit better.
These are things you can’t do by video link.
Moving the physical presence of the Prince of Wales from place to place is the life’s work of Charles Windsor; his personal contribution is his informed decision-making about which causes and organizations to grace with his attention. He doesn’t do anything — but he points out people who do, and by bringing them attention, encourages their work.
Even in republics, that job is considered important: distributing the physical presence of the President of the United States is a major responsibility of whoever holds the office — that’s why George W. Bush was in that classroom on the morning of 9/11, and why he went to the smoking ruin of the World Trade Center a couple of days later, and why he threw out the first pitch at Yankee Stadium a scant couple of weeks after that. The children would have been read to, the wreckage cleared, the pitch thrown out, without Bush’s participation. But ceremony and symbolism matter. Sometimes the boss, even if he’s only the boss by convention and doesn’t do very much personal bossing himself, has to go.
It’s certainly worthwhile for someone in Charles’s position to think carefully, or pay somebody to, about how to maximize the efficiency of his trips, both as a technical matter of technology — can he sleep on the train rather than flying in and sleeping when he gets there? — and to maximize the usefulness of each trip. I can’t see calling the guy a hypocrite for doing his job, though.
Posted in Britain, carbon, fossil fuels, transportation	Duelling clean-air acts
Posted in carbon, climate change, Conservative Party, John Baird, Kyoto, Liberal Party, public policy	Talking to Sam Shaw
Posted in Alberta, education, lifestyle, oilsands	← Older posts

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Fantastic Mr Fox joins economic partnership | News from Secret Agent Marketing
James Fox, headteacher at Abbeyfield School in Chippenham
On the outskirts of Chippenham is a glass-fronted building where some of the country’s youngest CEOs rub shoulders. Seventeen and 18 year olds chair board meetings, win contracts and pore over business strategies.
But this isn’t a cutting edge tech company staffed by cool entrepreneurs who drive Porsches home to their loft conversions at the end of the day – not yet, anyway; they’re still at school.
James Fox is a man with a plan. Not content with guiding 1,000 pupils through their academic studies at Abbeyfield School in Chippenham – which has been awarded a special Business and Enterprise status by the government – the headteacher wants to instil business acumen into his students too.
That’s why a range of real companies delivering services from web design to sports coaching and catering are run by students as part of their GCSE and A Level courses – to the delight of local business leaders.
And with lessons in Mandarin Chinese, Portuguese and Russian being added to the curriculum this year, with Hindi to follow, bosses engaged in international trade say they’ve finally found a head who talks their language.
From his office window, James can see a field that will soon be a business park, offering 15 units of accommodation to the school-based businesses, and for Chippenham companies looking for new premises.
And some of that site is earmarked as an eco-park, bringing together some of North Wiltshire’s environmentally-friendly businesses in one place.
James, who has a background in the financial sector, has a wealth of experience from the world of work – enough to know that Wiltshire’s employers demand more of the youngsters joining their firms than academic excellence.
“Listen to industry – that’s what the employers are saying,” says James. “Students are bright, but they aren’t work ready. They’ve been spoon-fed to get results, but none of their other talents have been developed.
“Exam success is important – and our maths and English results are the best they’ve ever been – but there’s more to education than grades. Our kids leave ready for the world of work. And if they want to go to university first, they’ll have skills that make them stand out in a competitive marketplace.”
Now James has joined the board of the North Wiltshire Economic Partnership, giving him the ear of the region’s business leaders and a say in the way the local authority delivers economic development.
Partnership manager Colette Mallon said: “When I met James I was so impressed by his enthusiasm, and it was clear that he understood the needs and concerns of local employers. We’re delighted to have him on the board.”
Posted in Business, Public Sector
« Bear-eaking news – latest news from Cirencester toy auction
£50,000 of antique toys sold at auction »
I’m not surprised by this as James used to work at my old school, Writhlington School in Somerset and he was a bundle of energy there. He was committed to development and engaging with the business community. This was, and is, a school which has a fantastic social enterprise which is world class – known as the Orchid Project. So glad to see that James is going from strength to strength.


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Browsing by Author De Silva, Deidre A.
2011 Associations of Retinal Microvascular Signs and Intracranial Large Artery Disease Lindley, Richard; Mitchell, Paul; Wang, Jie Jin; Chang, Hui-Meng; Chen, Christopher; De Silva, Deidre A.; Gan, Hui-Yee; Lee, Moi-Pin; Liu, Erica Yang; Manzano, J. J. F.; Wong, Meng-Cheong; Wong, Tien Yin; Woon, F.-P.; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Millennium Institute; Western Clinical School: Westmead Millennium Institute Associations of Retinal Microvascular Signs and Intracranial Large Artery Disease, Stroke, vol.42, 3, 2011,pp 812-814
2010 Differential Associations of Cortical and Subcortical Cerebral Atrophy With Retinal Vascular Signs in Patients With Acute Stroke Liew, Gerald; Lindley, Richard; Mitchell, Paul (Ronald); Rochtchina, Elena; Wang, Jie Jin; Baker, Michelle L; De Silva, Deidre A.; Hand, Peter J; Hankey, Graeme; Multicentre Retinal Stroke Study COLLABORATIVE GROUP, mcrs; Wardlaw, Joanna; Wong, Meng-Cheong; Wong, Tien Yin; Western Clinical School: Westmead Millennium Institute; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Millennium Institute; Western Clinical School: Clinical Ophthal & Eye Health; Western Clinical School: Westmead Millennium Institute Differential Associations of Cortical and Subcortical Cerebral Atrophy With Retinal Vascular Signs in Patients With Acute Stroke, Stroke: a journal of cerebral circulation, vol.41, 10,pp 2143-2150
2014 Differing associations of white matter lesions and lacunar infarction with retinal microvascular signs Liew, Gerald; Lindley, Richard; Mitchell, Paul; Rochtchina, Elena; Wang, Jie Jin; Baker, Michelle L; De Silva, Deidre A.; Hand, Peter; Hankey, Graeme; Null, Multi-Centre Retinal Stroke Study Group; Wardlaw, J. M.; Wong, Meng-Cheong; Wong, Tien Y; Western Clinical School: Clinical Ophthal & Eye Health; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Institute for Medical Res; Western Clinical School: Clinical Ophthal & Eye Health; Western Clinical School: Westmead Institute for Medical Res Differing associations of white matter lesions and lacunar infarction with retinal microvascular signs, International Journal of Stroke, vol.9, 7, 2014,pp 921-925
2012 The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients Lindley, Richard; Mitchell, Paul (Ronald); Wang, Jie Jin; Cameron, J D; Chang, Hui-Meng; Chen, Christopher; De Silva, Deidre A.; Kingwell, Bronwyn; Liu, Erica Yang; Manzano, J. J. F.; Wong, Mabel; Wong, T; Woon, F.-P.; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Millennium Institute; Western Clinical School: Westmead Millennium Institute The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients, Journal of Human Hypertension, vol.26, 12, 2012,pp 716-722
2011 Retinal microvascular changes and subsequent vascular events after ischemic stroke. Lindley, Richard; Mitchell, Paul (Ronald); Wang, Jie Jin; Chang, Hui-Meng; Chen, Christopher; De Silva, Deidre A.; Liu, Erica Yang; Manzano, J. J. F.; Wong, Meng-Cheong; Wong, T; Wong, W.-X.; Woon, F.-P.; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Millennium Institute; Western Clinical School: Westmead Millennium Institute Retinal microvascular changes and subsequent vascular events after ischemic stroke., Neurology, vol.77, 9, 2011,pp 896-903
2009 Retinal Vascular Caliber and Extracranial Carotid Disease in Patients With Acute Ischemic Stroke. The Multi-Centre Retinal Stroke (MCRS) Study Liew, Gerald; Lindley, Richard; Mitchell, Paul (Ronald); Rochtchina, Elena; Wang, Jie Jin; Baker, Michelle L; Chang, Hui-Meng; Chen, Christopher; De Silva, Deidre A.; Hand, Peter J; Liu, Erica Yang; Wong, Meng-Cheong; Wong, Tien Y.; Western Clinical School: Westmead Millennium Institute; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Millennium Institute; Western Clinical School: Clinical Ophthal & Eye Health; Western Clinical School: Westmead Millennium Institute Retinal Vascular Caliber and Extracranial Carotid Disease in Patients With Acute Ischemic Stroke. The Multi-Centre Retinal Stroke (MCRS) Study, Stroke: a journal of cerebral circulation, vol.40, 12,pp 3695-3699


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Blotter: Gun Fired at Occupied House, Man Rams Truck Over Parking Space - Police & Fire - Redwood City-Woodside, CA Patch
RedwoodCity-Woodside Nearby San Mateo Patch San Carlos Patch Belmont Patch Menlo Park-Atherton Patch Foster City Patch Palo Alto Patch Half Moon Bay Patch Burlingame-Hillsborough Patch See More Sign in/Join Get the Daily NewsletterJoinSign In Home News Boards Events Businesses Edit × Delete this post? Are you sure you want to delete this post? Delete Cancel × Reason for rejecting this post Suggest how they can make this post appropriate for this group Cancel Reject Now News | Police & Fire Blotter: Gun Fired at Occupied House, Man Rams Truck Over Parking Space The following information was supplied by the Redwood City Police Department. Where arrests or charges are mentioned, it does not indicate a conviction. Posted by Jennifer van der Kleut (Editor), October 25, 2012 at 12:43 pm Comment Recommend Flag as Inappropriate Loading... × Next Previous Slideshow Download Saturday, Oct. 13
1:25 a.m. - Disturbance: Someone called to report a homeless person living in an encampment at Seaport Blvd. and Blomquist Street, under the 101 freeway, was yelling and harassing passers-by. Arrest made.
10:00 a.m. - Gun Shot at Inhabited House: Reporting party said a bullet was shot through their roof around 9 p.m. last night. No suspect info. Report taken.
10:50 a.m. - Grand Theft: Occured on Woodside Road. A ring was taken, sometime the day before. Possible suspect info. Report taken.
12:25 p.m. - Suspicious Person: Occured at Valota Road and Redwood Avenue. Someone reported a white male dressed in a hat and glasses and carrying a briefcase hitchhiking. Police were unable to locate.
1:15 p.m. - Residential Burglary: Occured on Main Street. Reporting party said he/she was not sure when it happened. No suspect info. Jewelry taken. Point of entry was the door. Report taken.
1:16 p.m. - Drug Activity: Someone reported a Hispanic female smoking marijuana out in front of a home on Regent Court.
1:18 p.m. - Intoxicated Person: Occured at Jefferson Avenue and El Camino. A male walking on the median stumbled and almost fell into traffic. White male in his 40s wearing an orange shirt.
1:46 p.m. - Disturbance: Occured on Flood. A person called to report that, after a heated verbal fight occured between him and another man over a parking space, the other man purposely rammed into his truck with his van. Referred to other agency.
2:05 p.m. - Suspicious Circumstances: Occured on Cork Harbour Circle. Someone called to report possible computer hacking - when he/she logs into computer, gets a federal fraud alert message preventing log-in. Report taken.
6:40 p.m. - Residential Burglary: Occured on Woodside Road. Reporting party says it occured sometime within the past three weeks. Gold and jewelry taken. No suspect info. Report taken.
7:52 p.m. - Assault w/ a Deadly Weapon: Occured on Laurel Street. Reporting party said a group of 5-10 Hispanic males threw something at him, said he is bleeding. Report taken.
12:20 a.m. - Strong-Arm Robbery: Occured at Underground Pub on Broadway. Reporting person said an unknown person assaulted him from behind and stole his phone. No suspect description. Report taken.
12:31 a.m. - Occupied Suspicious Vehicle/Indecent Exposure: Someone called to report a green Dodge Durango parked in the Maple Street garage with a subject sitting in the back, possibly with no clothes on.
5:07 a.m. - Suspicious Person: Reporting person said he/she went out to his/her car and found a suspicious person in the car - a male subject wearing a red hoodie, about 5'4" and 160 pounds. Reporting party yelled and suspect took off on a bike toward Belle downtown. Officers were unable to locate.
8:58 a.m. - Civil Standby: Person requested standby for a child custody exchange in which there is a restraining order that only allows contact for exchanges.
9:13 a.m. - Stolen Vehicle: Occured at Woodside Road and Horgan Avenue. Car last seen on Oct. 13 at 8:30 p.m. Report taken.
1:43 p.m. - Disturbance/Fight: Occured on Main Street. Three Hispanic males. One had a chain in his hand and was swinging it around and hitting others. Arrest made.
2:29 p.m. - Commercial Burglary: Occured on Oddstad Drive. Reporting party said it occured sometime over the past couple of weeks. An air compressor and saw were taken. Report taken.
4:37 p.m. - Disorderly Conduct/Public Drunkeness: Occured on Spring Street. Report that a male who had been on a bicycle was now on the ground, possibly bleeding. People were helping him. Assistance was sent.
4:42 p.m. - Disturbance/Fight: Occured on Broadway. Report of a male and female in a fight in a parking lot. Fight both physical and verbal. Officers were unable to locate.
10:02 p.m. - Disturbance/Vandalism: Report of a white van in the parking lot of a restaurant - subjects inside were throwing rocks at an apartment building, hitting some windows. Report taken.
7:45 a.m. - Suspicious Person/Indecent Exposure: Occured on Buckeye Street. A white male with a beard was seen naked walking toward Stambaugh, wearing only cardboard.
5:32 p.m. - Disturbance: Occured on El Camino Real outside a restaurant's outdoor dining area. Report of a white male and white female who refused to leave, and were now yelling at security.
6:27 p.m. - Disturbance: Occured on Spring Street. Reporting person was in a verbal fight with a subject living in a motorhome. The motorhome owner was seen publicly bathing in a nearby faucet.
7:11 p.m. - Disturbance: Occured on El Camino Real. Business owner reported four subjects were trying to pass a counterfeit $20 bill. Subjects were gone upon officers' arrival. Comment Recommend Flag as Inappropriate Newsletter & Alerts Get the best stories each day and important breaking news Subscribe Not from Redwood City-Woodside Patch? Find your Local Patch » Comments + Leave a Comment Loading comments ... Who's Blogging? Sharon Levin Sharon Levin's thoughts and ruminations Read Sharon Levin's blog » Lily Hartzell I will provide a series of easy-to-do tips on how … Read Lily Hartzell's blog » Cliff Keith Redwood City's real estate market trends and open … Read Cliff Keith's blog » Paul Stewart Paul Stewart's thoughts and ruminations Read Paul Stewart's blog » Libi Uremovic Libi Uremovic's thoughts and ruminations Read Libi Uremovic's blog » Leonard Sklar Leonard Sklar's thoughts and ruminations Read Leonard Sklar's blog » QWERTY Education Services, Inc. QWERTY Education Services, Inc.'s thoughts and rum… Read QWERTY Education Services, Inc.'s blog » Beth Mostovoy Beth Mostovoy's thoughts and ruminations Read Beth Mostovoy's blog » Michael G. Stogner Michael G. Stogner's thoughts and ruminations Read Michael G. Stogner's blog » Become a blogger today! Get started now Start blogging × You are reposting to: Where do you want to post? Choose a category Add Categories: Add a category × Choose a section to post to Oops, looks like there are no groups in this filter. Select a category above. Repost Cancel Boards All Boards » × Note Article Just a short thought to get the word out quickly about anything in your neighborhood. Share something with your neighbors. Write a new post... What's up? Make an announcement, speak your mind, or sell something Post Stolen Art: Love Collage Still Missing: Reward For Safe Return

value: Patch.com is an American local news and information platform, primarily owned by Hale Global. As of June 2019, Patch's more than 100 journalists operated some 1,227 hyperlocal news websites, which also have an information component, in 50 U.S. states and Washington, D.C.Patch Media Corporation is the operator of the service.


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Velvet Brick: Update
I'd like to take a few minutes to say thank you to you.....You see... I've been a bit absent from my blog. The truth is, I have been working through some difficult times and emotions. My family's 'calendar' is clear through most of the year, except for Miss M's birthday at the end of May. But come Halloween, the roller coaster ride begins. For me this year, it has meant the anniversary of my mother's passing and her burial (on Halloween), my first anniversary officially divorced (after 29 years), my son's birthday, my birthday, throw in Thanksgiving, Christmas, and the ex's birthday after the new year.As a dear friend, J, recently said... 'You're not in the 'fight or flight' mode for the first time in years, so now you are feeling all of those emotions that you put to the side because you were in 'fight or flight'."The holidays are portrayed by 'Madison Avenue' as a Norman Rockwell vacation...a time of love,family, traditions and joy. Oh, how I ache for all of those things in my heart...in my being. But the truth is that, for many, there is also heartache, loss and sadness. I am working through all of these emotions...from love and joy, to loss and sadness. I am sure that I am probably not alone.So...I want to thank.... you.You have patiently allowed me to take time to privately work through so many emotions. You have checked in on me to just say 'hi' and see how I was doing. My dear girl, Paige... thank you for your hug and your checking in on me... you will never know how tender and kind those gestures were and what they meant to me. All of you have allowed me time...and for that, I am grateful.So, I thank you for your patience. I thank you for you kindness. I thank you for bearing with me. I thank you for your 'friendship'.Thank you.May your day unfold a special treasure for you tomorrow. You are most deserving of it!
Oh...it's so weird that first year...well, and some kind of weird after that...but, it does get better after more time passes. I am glad you are taking time to feel everything though...that's the only way I got through it all. I noticed I rushed around like a maniac like I was trying to replace all the nervousness that accompanied my fight or flight...I'm getting ready to just pick out the small things in the season that are meaningful JUST TO ME...and embrace those and hold on to them...rather than trying to duplicate all the other thingsI used to do...it's too tiring for me now to do all of that...and I deserve to finally have a good time the way I want to...Just like you do, my love! Keep hanging in there with all of this...it gets better...and remember to recognize all the magic of the season too...it may be small at first, but it's in the background jumping up and down waving its arms around...Big hugs and kissed to you...
Oh I LOVE what chickenbells has to say and share..... so true to embrace what is meanigful to JUST YOU!! Quite honestly my friend I can't wait to see you celebrate the things that matter to you and also to see what new traditions you will create. You my dear friend are a creative soul and so you will create new traditions and I hope to be a part of some of them!!Miss you tons from rainy Seattle!!J
I so think we need to meet this holiday season. I would love it. Perhaps for lunch.Big hugs to you as you are dealing with so many things.
passing by for a quick visit,come on over and sat a spell darling and see the Christmas give-a-way .
I've been thinking about you and wanted to check in to see how you are doing. I hope everyting is okay. Miss you...(((squishy hugs))) Love, Jolene
VB, I know a bit of what you're going through. My mom passed away last December 23rd and I've been separated for almost 4 months (after 19 years of marriage). I appreciate all your encouragement via emails and comments you've sent me. Your words have most certainly helped me, and hope I can do the same for you in return. I've been going through a roller coaster of emotions, but instead of fighting it, I'm going with the flow because I know that's where my healing will come from. "New Traditions" is my theme for this Christmas season. I'm wishing the same for you and your family! {{{VB}}} - God's blessings to you!


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Kind of a Big Deal | Running On Smores
Update me! →
July 25, 2011 · 6:10 pm	↓ Jump to Comments
It’s Monday and class is canceled. No babysitting on the agenda for today and I knocked my long run out yesterday.
12 responses to “Kind of a Big Deal”	reads recipes runs	July 25, 2011 at 7:03 pm	I’ve been working out sans music recently too! More by choice though. I don’t want to become reliant on my music to finish a workout, and it’s more of a mental workout too!
Reply	Smore	July 26, 2011 at 11:24 am	It is a great mental workout! I was so surprised at how relaxed I was throughout my run. I will definitely be doing that again.
Reply	Michelle @ milesforbreakfast	July 25, 2011 at 11:09 pm	I ran 13mi on Saturday and 5mi on Sunday.I always run with my ipod listening to either music or an audiobook. I just started with the audio book thing and I like it
Reply	Smore	July 26, 2011 at 11:25 am	WHOO!! A 5 mile run after 13 miles? You are awesome. I like the audiobook idea. I might wanna try that. Do you just download your audiobooks off itunes?
Reply	Chels	July 26, 2011 at 1:04 am	Nice work on your 14 miler! I always have to run with music, there has been times when my IPOD has died and I go crazy.
Reply	Smore	July 26, 2011 at 11:26 am	Thank you!! I really thought it was going to be terrible without my ipod but I surprised myself at how easy it was for me to just get into my zone. I left my run feeling super relaxed. Definitely recommend working out sans music every once in a while.
Reply	Courtney	July 26, 2011 at 8:10 pm	I never run or bike or swim with music! I ❤ it; exercise is my time to zone out. Plus, I can never keep headphones/earbuds in my ears, haha. I did run a hot 6.5 hilly run this weekend. Congrats on your 14!! 🙂
Reply	Smore	July 27, 2011 at 11:01 am	I used to have the ear phone problem too! Maybe my ears just adapted to them? Nice run this weekend! Hilly runs always take soo much out of me. Especially in the heat!
Reply	jeri	August 1, 2011 at 4:13 pm	I’m so glad you commented on my blog so it could lead me back to yours! Great job on teh 14 miler, and good call on not doing the LRs for “time.” Really they’re just so your body can get used to time on your feet to prepare yourself for 26.2.
Sometimes I love to ditch the ipod, especially on early morning runs where it seems like you’re the only one on the earth just runnin’ along. 🙂
Reply	Smore	August 3, 2011 at 4:08 pm	Aren’t morning runs the best? There is something about being up and doing something amazing before the world begins again. I love it.
Reply	livinghi	August 3, 2011 at 2:33 am	I recently was forced to do a run without music because my iPod was dead, and I was surprised at how nice it was. I felt like I could get into a better rhythm because I was more in tune with my body- hearing my breathing and the sound of my feet. It was only 6 miles, props to you for going on a long one without!
Reply	Smore	August 3, 2011 at 4:09 pm	Completely agree! I was surprised at how relaxed I was throughout my run. It’s so peaceful!


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Beauty Mountain Road Hibbing, MN home and property info
> Beauty Mountain Road homes Beauty Mountain Road homes
Beauty Mountain Road, Hibbing 55746 contains 16 assessor property records. 13017 Beauty Mountain Road, Hibbing MN
12683 Beauty Mountain Road, Hibbing MN
This home has 192 square feet and was built in 2014.
12773 Beauty Mountain Road, Hibbing MN
12689 Beauty Mountain Road, Hibbing MN
This 2 bedroom, 1.75 bathroom home has 1864 square feet and was built in 2014.
12675 Beauty Mountain Road, Hibbing MN
12705 Beauty Mountain Road, Hibbing MN
12701 Beauty Mountain Road, Hibbing MN
13048 Beauty Mountain Road, Hibbing MN
12699 Beauty Mountain Road, Hibbing MN
12677 Beauty Mountain Road, Hibbing MN
This 1 bathroom home has 620 square feet and was built in 1970.
13015 Beauty Mountain Road, Hibbing MN
This 3 bedroom, 2.25 bathroom home has 896 square feet and was built in 1978.
12745 Beauty Mountain Road, Hibbing MN
12835 Beauty Mountain Road, Hibbing MN
12693 Beauty Mountain Road, Hibbing MN
12691 Beauty Mountain Road, Hibbing MN
This 1 bedroom, 1.75 bathroom home has 960 square feet and was built in 1975.

value: Trulia is an American online real estate marketplace which is a subsidiary of Zillow. It facilitates buyers and renters to find homes and neighborhoods across the United States through recommendations, local insights, and map overlays that offer details on a commute, reported crime, schools, churches and nearby businesses.Founded in 2005, Trulia is based in San Francisco, and owned and operated by Zillow Group, Inc.


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Downtown MRT Station | Singapore Transport Wiki | Fandom powered by Wikia
Marina Bay	Downtown MRT Station
[[Template:Px|250px]]'
Downtown MRT Station (DT17) is the name for an underground Mass Rapid Transit station on the Downtown Line Stage 1 in Singapore, formerly known as the Downtown Extension. It will connect the southern part of Marina Bay where developments such as The Sail @ Marina Bay & the Marina Bay Financial Centre (MBFC) lie to the current Central Business District (CBD). The station will serve future commercial developments within the Marina Bay vicinity, and will be located under Central Boulevard.[1]
to DT14 Bugis 6:17 am 6:37 am 12:02 am
to DT19 Chinatown 6:07 am 6:33 am 11:51 pm
Retrieved from "http://sgtransport.wikia.com/wiki/Downtown_MRT_Station?oldid=5262"

value: Fandom (also known as Wikia before October 2016) is a wiki hosting service and domain operated by Fandom, Inc. (formerly known as Wikia, Inc.), a for-profit Delaware company founded in October 2004 by Jimmy Wales and Angela Beesley.


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Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia — Augusta University Research Profiles
Susan O'Brien, Moshe Talpaz, Jorge Cortes, Jianqin Shan, Francis J. Giles, Stefan Faderl, Deborah Thomas, Guillermo Garcia-Manero, Susie Mallard, Mary BethRios, Charles Koller, Steve Kornblau, Michael Andreeff, Anthony Murgo, Michael Keating, Hagop M. Kantarjian
BACKGROUND. Homoharringtonine (HHT) has antileukemic activity in patients with Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML). Combinations of HHT, interferon-α (IFN-α), and cytarabine (ara-C) have been studied in various CML phases. The objectives of this study were to evaluate the efficacy and toxicity profiles of a combination regimen of simultaneous HHT and IFN-α therapy in patients with chronic-phase CML who were not exposed previously to either agent. METHODS. Forty-seven patients were treated: 37 patients with early chronic-phase CML (2 patients with clonal evolution) and 10 patients with late chronic-phase CML. Their median age was 62 years (range, 23-73 years). HHT was given at a dose of 2.5 mg/m 2 by continuous intravenous infusion over 24 hours daily for 5 days every month, and IFN-α was given daily at a target dose of 5 × 10 6 units/m 2 subcutaneously. Response, survival, and treatment toxicity were analyzed. RESULTS. Overall, the complete hematologic response (CHR) rate was 85%; the cytogenetic response rate was 66%, with major cytogenetic responses (Ph positive in < 35% of metaphases) in 49% of patients and complete cytogenetic responses in 21% of patients. The CHR rate, cytogenetic response rate, and major cytogenetic response rate were 84%, 69%, and 52%, respectively, in patients with early chronicphase CML. Among the 10 patients with late chronic-phase CML, the CHR rate, cytogenetic response rate, and major cytogenetic response rate were 80%, 50%, and 40%, respectively. Response rates in patients age > 60 years were 84%, 62%, and 49% for CHR, cytogenetic response, and major cytogenetic response. Myelosuppression was frequent but manageable: Anemia with hemoglobin < 8.0 g/dL occurred in 36% of patients, requiring dose adjustments and erythropoietin therapy. Nonhematologic toxicities were mainly fatigue, aches, and gastrointestinal disturbances. Dose reductions with multiple courses were significant and were due to myelosuppression: After 6-24 courses, the median daily IFN-α dose was 1 MU/m 2, and the median number of days on HHT per month was 2 days. With a median follow-up of 26 months, the estimated 2-year survival rate was 90% (95% confidence interval, 79-100%). CONCLUSIONS. The simultaneous combination of HHT and IFN-α is safe and effective, but the dose schedules that actually were delivered were significantly lower than the planned dose schedules. With the availability of signal-transductior inhibitor 571 (imatinib mesylate), studies of combination of HHT and IFN-α chemotherapy in patients with CML who have disease that fails to respond to imatinib mesylate and of combinations with imatinib mesylate need to be explored.
https://doi.org/10.1002/cncr.10436
Fingerprint Dive into the research topics of 'Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia'. Together they form a unique fingerprint.
O'Brien, S., Talpaz, M., Cortes, J., Shan, J., Giles, F. J., Faderl, S., Thomas, D., Garcia-Manero, G., Mallard, S., BethRios, M., Koller, C., Kornblau, S., Andreeff, M., Murgo, A., Keating, M., & Kantarjian, H. M. (2002). Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia. Cancer, 94(7), 2024-2032. https://doi.org/10.1002/cncr.10436
Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia. / O'Brien, Susan; Talpaz, Moshe; Cortes, Jorge; Shan, Jianqin; Giles, Francis J.; Faderl, Stefan; Thomas, Deborah; Garcia-Manero, Guillermo; Mallard, Susie; BethRios, Mary; Koller, Charles; Kornblau, Steve; Andreeff, Michael; Murgo, Anthony; Keating, Michael; Kantarjian, Hagop M.
In: Cancer, Vol. 94, No. 7, 01.04.2002, p. 2024-2032.
O'Brien, S, Talpaz, M, Cortes, J, Shan, J, Giles, FJ, Faderl, S, Thomas, D, Garcia-Manero, G, Mallard, S, BethRios, M, Koller, C, Kornblau, S, Andreeff, M, Murgo, A, Keating, M & Kantarjian, HM 2002, 'Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia', Cancer, vol. 94, no. 7, pp. 2024-2032. https://doi.org/10.1002/cncr.10436
O'Brien S, Talpaz M, Cortes J, Shan J, Giles FJ, Faderl S et al. Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia. Cancer. 2002 Apr 1;94(7):2024-2032. https://doi.org/10.1002/cncr.10436
O'Brien, Susan ; Talpaz, Moshe ; Cortes, Jorge ; Shan, Jianqin ; Giles, Francis J. ; Faderl, Stefan ; Thomas, Deborah ; Garcia-Manero, Guillermo ; Mallard, Susie ; BethRios, Mary ; Koller, Charles ; Kornblau, Steve ; Andreeff, Michael ; Murgo, Anthony ; Keating, Michael ; Kantarjian, Hagop M. / Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia. In: Cancer. 2002 ; Vol. 94, No. 7. pp. 2024-2032.
@article{03f0a5bf36d748188f28ed283bb1ceca,
title = "Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia",
abstract = "BACKGROUND. Homoharringtonine (HHT) has antileukemic activity in patients with Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML). Combinations of HHT, interferon-α (IFN-α), and cytarabine (ara-C) have been studied in various CML phases. The objectives of this study were to evaluate the efficacy and toxicity profiles of a combination regimen of simultaneous HHT and IFN-α therapy in patients with chronic-phase CML who were not exposed previously to either agent. METHODS. Forty-seven patients were treated: 37 patients with early chronic-phase CML (2 patients with clonal evolution) and 10 patients with late chronic-phase CML. Their median age was 62 years (range, 23-73 years). HHT was given at a dose of 2.5 mg/m 2 by continuous intravenous infusion over 24 hours daily for 5 days every month, and IFN-α was given daily at a target dose of 5 × 10 6 units/m 2 subcutaneously. Response, survival, and treatment toxicity were analyzed. RESULTS. Overall, the complete hematologic response (CHR) rate was 85%; the cytogenetic response rate was 66%, with major cytogenetic responses (Ph positive in < 35% of metaphases) in 49% of patients and complete cytogenetic responses in 21% of patients. The CHR rate, cytogenetic response rate, and major cytogenetic response rate were 84%, 69%, and 52%, respectively, in patients with early chronicphase CML. Among the 10 patients with late chronic-phase CML, the CHR rate, cytogenetic response rate, and major cytogenetic response rate were 80%, 50%, and 40%, respectively. Response rates in patients age > 60 years were 84%, 62%, and 49% for CHR, cytogenetic response, and major cytogenetic response. Myelosuppression was frequent but manageable: Anemia with hemoglobin < 8.0 g/dL occurred in 36% of patients, requiring dose adjustments and erythropoietin therapy. Nonhematologic toxicities were mainly fatigue, aches, and gastrointestinal disturbances. Dose reductions with multiple courses were significant and were due to myelosuppression: After 6-24 courses, the median daily IFN-α dose was 1 MU/m 2, and the median number of days on HHT per month was 2 days. With a median follow-up of 26 months, the estimated 2-year survival rate was 90% (95% confidence interval, 79-100%). CONCLUSIONS. The simultaneous combination of HHT and IFN-α is safe and effective, but the dose schedules that actually were delivered were significantly lower than the planned dose schedules. With the availability of signal-transductior inhibitor 571 (imatinib mesylate), studies of combination of HHT and IFN-α chemotherapy in patients with CML who have disease that fails to respond to imatinib mesylate and of combinations with imatinib mesylate need to be explored.",
keywords = "Chronic myeloid/myelogenous leukemia, Chronic phase, Homoharringtonine, Interferon-α",
author = "Susan O'Brien and Moshe Talpaz and Jorge Cortes and Jianqin Shan and Giles, {Francis J.} and Stefan Faderl and Deborah Thomas and Guillermo Garcia-Manero and Susie Mallard and Mary BethRios and Charles Koller and Steve Kornblau and Michael Andreeff and Anthony Murgo and Michael Keating and Kantarjian, {Hagop M.}",
doi = "10.1002/cncr.10436",
T1 - Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia
AU - BethRios, Mary
N2 - BACKGROUND. Homoharringtonine (HHT) has antileukemic activity in patients with Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML). Combinations of HHT, interferon-α (IFN-α), and cytarabine (ara-C) have been studied in various CML phases. The objectives of this study were to evaluate the efficacy and toxicity profiles of a combination regimen of simultaneous HHT and IFN-α therapy in patients with chronic-phase CML who were not exposed previously to either agent. METHODS. Forty-seven patients were treated: 37 patients with early chronic-phase CML (2 patients with clonal evolution) and 10 patients with late chronic-phase CML. Their median age was 62 years (range, 23-73 years). HHT was given at a dose of 2.5 mg/m 2 by continuous intravenous infusion over 24 hours daily for 5 days every month, and IFN-α was given daily at a target dose of 5 × 10 6 units/m 2 subcutaneously. Response, survival, and treatment toxicity were analyzed. RESULTS. Overall, the complete hematologic response (CHR) rate was 85%; the cytogenetic response rate was 66%, with major cytogenetic responses (Ph positive in < 35% of metaphases) in 49% of patients and complete cytogenetic responses in 21% of patients. The CHR rate, cytogenetic response rate, and major cytogenetic response rate were 84%, 69%, and 52%, respectively, in patients with early chronicphase CML. Among the 10 patients with late chronic-phase CML, the CHR rate, cytogenetic response rate, and major cytogenetic response rate were 80%, 50%, and 40%, respectively. Response rates in patients age > 60 years were 84%, 62%, and 49% for CHR, cytogenetic response, and major cytogenetic response. Myelosuppression was frequent but manageable: Anemia with hemoglobin < 8.0 g/dL occurred in 36% of patients, requiring dose adjustments and erythropoietin therapy. Nonhematologic toxicities were mainly fatigue, aches, and gastrointestinal disturbances. Dose reductions with multiple courses were significant and were due to myelosuppression: After 6-24 courses, the median daily IFN-α dose was 1 MU/m 2, and the median number of days on HHT per month was 2 days. With a median follow-up of 26 months, the estimated 2-year survival rate was 90% (95% confidence interval, 79-100%). CONCLUSIONS. The simultaneous combination of HHT and IFN-α is safe and effective, but the dose schedules that actually were delivered were significantly lower than the planned dose schedules. With the availability of signal-transductior inhibitor 571 (imatinib mesylate), studies of combination of HHT and IFN-α chemotherapy in patients with CML who have disease that fails to respond to imatinib mesylate and of combinations with imatinib mesylate need to be explored.
AB - BACKGROUND. Homoharringtonine (HHT) has antileukemic activity in patients with Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML). Combinations of HHT, interferon-α (IFN-α), and cytarabine (ara-C) have been studied in various CML phases. The objectives of this study were to evaluate the efficacy and toxicity profiles of a combination regimen of simultaneous HHT and IFN-α therapy in patients with chronic-phase CML who were not exposed previously to either agent. METHODS. Forty-seven patients were treated: 37 patients with early chronic-phase CML (2 patients with clonal evolution) and 10 patients with late chronic-phase CML. Their median age was 62 years (range, 23-73 years). HHT was given at a dose of 2.5 mg/m 2 by continuous intravenous infusion over 24 hours daily for 5 days every month, and IFN-α was given daily at a target dose of 5 × 10 6 units/m 2 subcutaneously. Response, survival, and treatment toxicity were analyzed. RESULTS. Overall, the complete hematologic response (CHR) rate was 85%; the cytogenetic response rate was 66%, with major cytogenetic responses (Ph positive in < 35% of metaphases) in 49% of patients and complete cytogenetic responses in 21% of patients. The CHR rate, cytogenetic response rate, and major cytogenetic response rate were 84%, 69%, and 52%, respectively, in patients with early chronicphase CML. Among the 10 patients with late chronic-phase CML, the CHR rate, cytogenetic response rate, and major cytogenetic response rate were 80%, 50%, and 40%, respectively. Response rates in patients age > 60 years were 84%, 62%, and 49% for CHR, cytogenetic response, and major cytogenetic response. Myelosuppression was frequent but manageable: Anemia with hemoglobin < 8.0 g/dL occurred in 36% of patients, requiring dose adjustments and erythropoietin therapy. Nonhematologic toxicities were mainly fatigue, aches, and gastrointestinal disturbances. Dose reductions with multiple courses were significant and were due to myelosuppression: After 6-24 courses, the median daily IFN-α dose was 1 MU/m 2, and the median number of days on HHT per month was 2 days. With a median follow-up of 26 months, the estimated 2-year survival rate was 90% (95% confidence interval, 79-100%). CONCLUSIONS. The simultaneous combination of HHT and IFN-α is safe and effective, but the dose schedules that actually were delivered were significantly lower than the planned dose schedules. With the availability of signal-transductior inhibitor 571 (imatinib mesylate), studies of combination of HHT and IFN-α chemotherapy in patients with CML who have disease that fails to respond to imatinib mesylate and of combinations with imatinib mesylate need to be explored.
KW - Chronic myeloid/myelogenous leukemia
UR - http://www.scopus.com/inward/record.url?scp=0036534203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036534203&partnerID=8YFLogxK
U2 - 10.1002/cncr.10436
DO - 10.1002/cncr.10436
C2 - 11932905
AN - SCOPUS:0036534203

value: Elsevier (Dutch: [ˈɛlzəviːr]) is a Netherlands-based publishing company specializing in scientific, technical, and medical content. It is a part of the RELX Group, known until 2015 as Reed Elsevier.


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Economists have declared the non-farm economy is heading into recession after a National Australia Bank (NAB) monthly survey found business confidence is at a record low.
The NAB index dropped one point in November to a new low of negative-30 as forward orders fell to 1991 levels.
Confidence is down across all industries and all sectors apart from mining and transport are reporting their actual business conditions worsened last month.
NAB chief economist Alan Oster now says the total economy will contract this quarter.
"We wouldn't say there's a recession in the total economy, but it does look like the non-farm economy is probably going to be going into a moderate recession," he said.
NAB has also cut growth forecasts for next year which had predicted gross domestic product would expand by 1.3 per cent.
The bank is now expecting the economy to grow by just 0.5 per cent.
Earlier today Dun and Bradstreet released its survey of business expectations, which showed executives are expecting sales and profits to continue to worsen.
Nearly one in five executives surveyed expected to have fewer staff in the quarter ahead than they did a year ago.
Dun and Bradstreet's managing director Christine Christian says the drop in the Australian dollar has shaken business confidence.
"Very few businesses are planning to create new jobs in the coming quarter," she said.
"Most businesses are concerned at the flow-on effect the recent layoffs particularly by the finance sector and what impact that's going to have on the economy more generally."
Warning: Save your dollars because we're not going to hear about it on the 6 O'clock news but we're heading for a depression not just a recession. It is very predictable and the worst case could be something up to the level of the Great Depression which was 20 per cent unemployment and lasting up to a decade.
Financial crisis will hurt jobs, Swan warns
Job losses across Australia will be inevitable as the effects of the global financial crisis hit Australian businesses, Treasurer Wayne Swan says.
States 'dreaming' over extra funding
Prime Minister Kevin Rudd says he will not bow to pressure from states to provide billions of dollars in extra funding.
Associate Professor Steven Keen.
Labels: 2008, Australia, business-economics-and-finance, economic-trends, industry, international-financial-crisis