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Into The Wild Trail Rides in Gates, Oregon | Groupon
2.5-Hour Trail Rides for Two at Into The Wild Equine Adventures. Choose Between Two Options. Mill City
Intimate horseback tours Picturesque trail ways
Expertly trained horses
Limit 1 per person, may buy 1 additional as a gift. Limit 1 per visit. Valid only for option purchased. Reservation required, subject to availability. Must sign waiver.
Until mankind first stepped outside in 1934, nature was thought to be a fanciful myth, like yogurt or the clutch hitter. Spend a few hours frolicking through the fresh air of truth with today's Groupon to Into The Wild Equine Adventures. Choose between two options:
For $149, you get a 2.5-hour trail ride for two during the prime season, July 1–September 14 (a $298 value).
For $125, you get a 2.5-hour trail ride for two during the off-season, May 1–June 30 or September 15–November 1 (a $298 value).
Led by equine experts Sheila and Jahn Hoover, Into The Wild lopes trail-bound trotters through intimate, guided rides along the majestic Monument Peak trail system in the Santiam State Forest. After a roughly 30-minute introduction to broncos and riding safety, Into The Wild pairs horses and riders based on riding experience, compatibility, and wine preferences. Sharp stallions get an Ivy League–education from Sheila and Jahn, both of whom have studied Clinton Anderson's natural horsemanship techniques, and stay current with barefoot hooves, secure Australian saddles, and chic bitless bridles. Golden sunlight bursts through overhanging maple trees as an expert tour guide leads a cadre of four clip-cloppers through a weaving path of diverse foliage, magnificent meadows, clear streams, and fast-food options, imparting trivia about the route's historical, geological, and botanical hallmarks. Commemorate the day with one of the hoof-path's hundreds of photo opportunities, as commanding thumbs stand at attention when posing in front of breathtaking views of the Cascade Mountains and Santiam Valley. Into The Wild is the one of the few trail-riding outfits allowed on the Monument Peak trail system, which is a nonmotorized pathway and traversed only by hikers, mountain bikers, and backpacked bands of sasquatches. Into The Wild Equine Adventures Whereas Sheila grew up in a large city, reading books on horsemanship and dreaming of open trails, Jahn was practically born on the saddle, owning his first horse at 10 and fully training one by 17. Today, at Into The Wild Equine Adventures, the Hoovers—Sheila and Jahn are now married—share their lifelong passion by leading small-group trail rides along Oregon's miles of trails and naturally occurring treadmills, helping visitors connect with nature through both their surroundings and their steeds. As the head guide, Jahn provides every rider with personalized attention and works to ensure comfort by outfitting the mounts with foam-padded Australian saddles. Along with leading expeditions into verdant forests and snow-covered canyons, Into The Wild Equine Adventures serves as the only trail-riding company in the state of Oregon with permission to access the Monument Peak Trail System—12 miles of multiuse trails unfettered by motorized ATVs or steam-powered moose.:m]] Customer Reviews

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Congress Must Avoid Spooking Markets on Debt Limit, Wyden Says - Bloomberg
Congress Must Avoid Spooking Markets on Debt Limit, Wyden Says
Democrat urges Congress to avoid causing debt prioritization
Spending-bill increase cited as model for debt-ceiling issue
The U.S. debt limit needs to be raised in a “calm, thoughtful” manner that steers clear of political uncertainty that would spook markets, Democratic Senator Ron Wyden said.
Congress must avoid any political standoff that could set in motion “disruptive activities” such as a need to choose which bills to pay and which to delay, Wyden of Oregon, the top Democrat on the Senate Finance Committee, said Friday in an interview with Bloomberg News.
The government will reach its statutory limit on borrowing sometime in October, the Congressional Budget Office estimates. President Donald Trump’s administration has asked Congress to raise the ceiling before then, but it’s running into the same complications the Obama White House encountered: lawmakers, mostly Republicans, who want to use the debt limit as leverage to force unrelated policy changes.
Wyden said he prefers a clean debt-ceiling increase, one without any controversial policy riders. Trump’s administration has been divided on that issue, with Treasury Secretary Steven Mnuchin pushing for a clean bill while budget director Mick Mulvaney and White House economic adviser Gary Cohn have said they’re open to adding spending cuts or other riders to a measure to increase the limit.
While having a Republican-controlled Congress should be seen as a benefit to Trump in driving his agenda, this week’s failure of Republican efforts to pass health-care legislation led to deepening anxiety over whether legislators will be able to agree on raising or suspending the debt ceiling before cash runs out.
Concerns have surfaced in the Treasuries market, with traders willing to pay more for bills maturing after Oct. 19 to avoid being caught holding securities vulnerable to a technical default. Yields on Treasury bills maturing Oct. 19 have risen by about 10 basis points from Wednesday through Friday, exceeding those on bills maturing later in the year.
Market participants are also worried that a once-secret plan written by the Obama administration may be called into action by Trump should Congress reach an impasse on raising the debt limit. That blueprint, developed in 2011 -- the same year the U.S. credit rating was cut for the first time -- would mean the U.S. would prioritize payments on government securities over other obligations.
While behind closed doors the Treasury Department is trying to reassure bond traders that it isn’t considering such a plan this year, Mnuchin has recently declined to publicly say that he wouldn’t prioritize payments. He did make such a statement in January during his confirmation hearing.
Wyden said the model for handling the debt-ceiling increase was set earlier this year, when Republicans and Democrats avoided a government shutdown by passing a $1.17 trillion spending bill that set aside partisan priorities. Among other things, Republicans ignored Trump’s call to include funding for a wall at the U.S.-Mexico border.
Still, he expressed concern about the global and financial implications of the political uncertainty surrounding the Trump administration amid a Russia investigation and a stagnant policy agenda.
— With assistance by Laura Litvan, and Alex Harris

type: global

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Patent US7256468 - Light emitting device - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsA light emitting device comprises a light emitting element, a metal package having a recess part for housing the light emitting element and a base part which has one or more through holes, and one or more lead electrode pins which penetrate the through holes and are separated from the through holes by...http://www.google.com/patents/US7256468?utm_source=gb-gplus-sharePatent US7256468 - Light emitting deviceAdvanced Patent SearchPublication numberUS7256468 B2Publication typeGrantApplication numberUS 11/123,109Publication dateAug 14, 2007Filing dateMay 6, 2005Priority dateApr 17, 2001Fee statusPaidAlso published asUS7019335, US20040120155, US20050194601, WO2002089219A1Publication number11123109, 123109, US 7256468 B2, US 7256468B2, US-B2-7256468, US7256468 B2, US7256468B2InventorsRyoma SuenagaOriginal AssigneeNichia CorporationExport CitationBiBTeX, EndNote, RefManPatent Citations (12), Referenced by (3), Classifications (61), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetLight emitting device
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS5973337 *Aug 25, 1997Oct 26, 1999Motorola, Inc.Ball grid device with optically transmissive coatingUS6031253 *Sep 29, 1998Feb 29, 2000Kyocera CorporationPackage for housing photosemiconductor deviceUS6034424 *Jul 29, 1997Mar 7, 2000Sumitomo Electric Industries, Ltd.Package and optoelectronic deviceUS6365920 *Mar 18, 1997Apr 2, 2002Korvet LightsLuminescent diodeUS6552368 *Sep 28, 2001Apr 22, 2003Omron CorporationLight emission deviceUS6831305 *Apr 10, 2002Dec 14, 2004Toyoda Gosei Co., Ltd.Semiconductor light-emitting deviceUS20030098460 *Apr 10, 2002May 29, 2003Takemasa YasukawaSemiconductor light-emitting deviceJP2000058924A Title not availableJP2000252524A Title not availableJPH0425257U Title not availableJPS51113375U Title not availableJPS60106356U Title not available* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS7694432 *Aug 19, 2004Apr 13, 2010Niclas ErikssonMethod for dehumidificationUS8173454 *Jan 21, 2010May 8, 2012Intops LED Co., Ltd.Light emitting diode package and method of manufacturing the sameUS20110140143 *Jan 21, 2010Jun 16, 2011Hyung Tae KimLight emitting diode package and method of manufacturing the same* Cited by examinerClassifications U.S. Classification257/434International ClassificationH01L33/50, H01L33/32, H01L33/64, H01L31/0203, H01L27/15Cooperative ClassificationH01L2224/32245, H01L2924/12041, H01L2924/01019, H01L2924/01074, H01L2924/01004, H01L2924/01039, H01L2924/01079, H01L33/642, H01L2924/01065, H01L2924/01056, H01L2924/01078, H01L2924/01021, H01L2924/01059, H01L2924/01038, H01L2924/01063, H01L2924/01075, H01L2924/01005, H01L2924/0102, H01L2224/49113, H01L33/62, H01L2224/73265, H01L24/49, H01L2924/01057, H01L33/483, H01L2924/01024, H01L2224/48091, H01L2924/0105, H01L33/507, H01L2224/49107, H01L2924/01033, H01L2924/014, H01L2924/01073, H01L2924/01049, H01L2924/0103, H01L2924/01012, H01L2224/4823, H01L2924/01052, H01L2924/10329, H01L2924/01047, H01L2924/0106, H01L2924/01082, H01L2924/01013, H01L2924/01032, H01L2924/01006, H01L2924/01029, H01L2924/01066, H01L2924/01058, H01L2224/48465, H01L2224/45144, H01L2224/45139, H01L2224/45124, H01L24/45European ClassificationH01L33/62, H01L33/64C, H01L24/49Legal EventsDateCodeEventDescriptionJan 14, 2011FPAYFee paymentYear of fee payment: 4RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services

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Poziom Cukru We Krwi Norma | eBay Please enable JavaScript Our new search experience requires JavaScript to be enabled. Please enable JavaScript on your browser, then try again.
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Your Amazon.comToday's DealsGift Cards & RegistrySellHelpClick to call our Disability Customer Support line, or reach us directly at 1-888-283-1678 Coaching Agile Teams: A Companion for ScrumMasters, Agile Coaches, and...
Customer Reviews4.2 out of 5 stars704.2 out of 5 stars5 star62%4 star23%3 star7%2 star4%1 star4%Coaching Agile Teams: A Companion for ScrumMasters, Agile Coaches, and Project Managers in Transition (Addison-Wesley Signature Series (Cohn))byLyssa AdkinsFormat: Paperback|ChangePrice:$38.26+ Free shipping with Amazon PrimeYour rating(Clear)Rate this itemYour rating
5.0 out of 5 starsYou can be a coach too - well maybe with hard work.Byiamspy007on March 26, 2016Understanding your position as a coach is imperative. It's too bad that hiring managers and HR reps don't read this book before looking for a Scrum Coach. In a recent interview the interview started off with an HP rep making the statement: "We are looking for a strong Project Manager who can take control of the Project Teams using the Agile methodology to get projects completed." Strong? Take control? Methodology? All key words to let you know someone is missing the boat. As Lyssa Adkins points out in this book it's about the team working with a collaborative, committed manner, responsible for getting the team to function at their very best. The Agile coach brings to the table past knowledge to influence the direction of the team. She brings real life working examples, both ones that work and why some things fail. Reading through these examples will invite you to do some soul searching on your past projects.
Top critical reviewSee all 11 critical reviews› 36 people found this helpful
All reviewersVerified purchase onlyVerified purchase onlyAll stars5 star only4 star only3 star only2 star only1 star onlyAll positiveAll critical3 star onlyAll formatsFormat: PaperbackAll formatsSearchThere was a problem filtering reviews right now. Please try again later.Showing 1-3 of 3 reviews(3 star, Verified Purchases).
See all 70 reviews3.0 out of 5 starsBook Review: Coaching Agile Teams, AdkinsByFrank Souderson April 20, 2011Format: Paperback|Verified Purchase- A small group of Agile Austin members divided Lyssa Adkins' "Coaching Agile Teams" into four parts and met bi-weekly over the course of two months to discuss each part's content. The opinions of those who participated in this `book club experience' varied and the related discussions were certainly informative and entertaining. Some members of the group will be posting a personal review of the book.- One of the primary elements that run the course of this book is the author's *journey* from Project Manager to ScrumMaster to Work/Life Coach to Agile Coach. Having taken this path, the author shares her firsthand experiences through anecdotes and advice while addressing other roles and perspectives often encountered in agile projects. She bolstered these areas with content from historically relevant discussions, input gathered via strategic interviews, casual research/discussion, and jewels of knowledge from well cited sources.- Most of the book's chapters end with a summary/refresher, a list of additional resources, and a list of references. In my opinion, these subsections of the book's chapters comprise the book's biggest take-away. I think of them as a reasonably well-constructed compendium that I plan to use on my *journey* forward.- Admittedly, I would not have read past the first few chapters if I had not been part of the related discussion group, as I found the content rather wordy. Not to belabor that point, but in certain instances, the book's figures and tables came as a welcome relief or nice break from the text. I appreciate Lyssa Adkin's sharing her knowledge and experience, and while I wasn't a particularly captivated by the book in terms of signal to noise, I'm sure others will find it a pleasant read.0Comment|
There was a problem loading comments right now. Please try again later.3.0 out of 5 starsA focus on Coaching rather than AgileByM. A. Sherrillon July 30, 2016Format: Paperback|Verified PurchaseAs a new Scrum Master I was disappointed with the “touchy-feely” nature of this book. The emphasis of the book is strongly on “Coaching”, and much less on “Agile” practices.I would recommend looking carefully at the Table of Contents before buying. Topics like “Make Agile Coaching Your Personal Expression” give a sense of the Right Brain nature of the content.I am giving three stars rather than two, since in hindsight this book is clearly about Coaching, rather than being a good Scrum Master.0Comment|Was this review helpful to you?YesNoReport abuseCommentInsert product linkPaste the product's web address below:Product not found. Only products offered on Amazon can be linked.SelectWhat's this?What are product links?In the text of your review, you can link directly to any product offered on Amazon.com. To insert a product link, follow these steps:1. Find the product you want to reference on Amazon.com2. Copy the web address of the product3. Click Insert product link4. Paste the web address in the box5. Click Select6. Selecting the item displayed will insert text that looks like this: [[ASIN:014312854XHamlet (The Pelican Shakespeare)]]
There was a problem loading comments right now. Please try again later.3.0 out of 5 starsThree StarsByshandianxiaon December 27, 2016Format: Kindle Edition|Verified Purchasegood concepts but a little overly theoristic0Comment|Was this review helpful to you?YesNoReport abuseCommentInsert product linkPaste the product's web address below:Product not found. Only products offered on Amazon can be linked.SelectWhat's this?What are product links?In the text of your review, you can link directly to any product offered on Amazon.com. To insert a product link, follow these steps:1. Find the product you want to reference on Amazon.com2. Copy the web address of the product3. Click Insert product link4. Paste the web address in the box5. Click Select6. Selecting the item displayed will insert text that looks like this: [[ASIN:014312854XHamlet (The Pelican Shakespeare)]]
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- Now starring as Michael Jordan: Allen Iverson
Now starring as Michael Jordan: Allen Iverson
Allen Iverson says he just had a large amount of fluid drained from his left knee.
An aging superstar, after trying retirement on for size, finds a new team.
Despite everything he has done, despite everything he has won, believe it or not, there are still those who doubt him. They must be taught otherwise.
Amazingly, some do not know the depths of the competitiveness in the man's soul. Age, slowing him? Please.
He graces a mediocre team with his big name and big game, creates a fan sensation, sells some tickets and prepares, in his mind, to rewrite the history of the franchise by mixing his improved jumper with the creative and daring forays into the paint that made him famous.
Only ... returning from the layoff is tough. The aging is real. The drives into the paint are met with bigger, stronger, faster and younger defenders.
There are some stumbling blocks out of the gate. The body is not quite what it once was. There are some losses.
The internet has always said this celebrity is like a zillion others in enjoying the nightlife. Who cares? Maybe nobody. But it's clear the player did not arrive in championship form, and may have to "play into shape" a little.
Some of what's happening with the body, though. That's new. Check out all the fluid in that knee. Draining that fluid helps the symptoms, but trainers and doctors agree draining the fluid doesn't do much about the underlying cause. Addressing that the conventional way is extremely time consuming, and is centered on weeks or months of taking it easy.
This is the story of Michael Jordan, long-retired Bull, as a brand-new Wizard in 2001.
"There was only the illusion of a remedy," writes Michael Leahy in his book about Jordan's return, "When Nothing Else Matters." "After the draining of the knee, Jordan could move again. But the tendon remained inflamed -- a draining did nothing for inflammation. If he did not rest, the pain would be coming back, along with more inflammation, more swelling, a nastier case of restricted movement and a heightened chance for another injury."
A major point of Leahy's book is that Jordan didn't listen to his body, nor anybody else. He pushed too hard. He had the whole franchise at his beck and call, with nobody to temper his impulse to play through anything and everything. And the dark cloud of knee trouble parked itself over the entire season. In the final analysis of that season, Jordan played just two-thirds of his typical workload, sitting out 22 of Washington's 82 games, seeing just about 2,000 minutes of action, compared to his typical 3,000+. When he did play, by just about every measure he was the worst he had been as a pro. His field goal percentage, his rebounding rate, his PER ... all down.
Coincidentally, word that Jordan's knee had been drained became public before a 2001 game in Philadelphia, where Jordan faced the upstart Allen Iverson. The younger guard's team was fresh off the NBA Finals and was heavily favored against the bickering Wizards.
That very night Reebok announced a lifetime Reebok contract for Iverson. Iverson and Jordan were on track to start side-by-side in the All-Star game. Iverson was threatening.
It was a shootout. Jordan launched 27 attempts, Iverson 31. But, with a sleeve over his right knee, Jordan scored 30 points, the win and the bragging rights. The day before, Wizards coach Doug Collins had promised to limit Jordan's minutes, but that was quickly forgotten as Jordan played all but ten minutes. He was notably slowed by the end of the game, but had 14 straight decisive points in the first half, putting the youthful Iverson -- who scored 40 in a losing effort -- in his place.
Eight years later, it's a whole new story, but a familiar one. Jordan is in retirement, a status Iverson is tip-toeing around. Now Iverson's the aging star on the bad team, fighting the years and the younger defenders in the paint, looking to win an improved legacy.
And, the fluid is now in his knee.
One of the reasons to have a veterans like Allen Iverson on your team is because players like that have been through the wars, and have learned from the things they have seen first-hand. What lesson does Iverson take from Jordan's experience? That knees are to be babied in the latter stages of one's career? That conditioning is king? Or that conventional advice be damned, toughness is the card that trumps all others.
Evidently, the latter. Iverson says he just had an enormous amount of fluid drained from his left knee. And he adds that there's almost no chance the knee will keep him from playing.
Iverson, as quoted by Bob Cooney on Philly.com about the large quantity of fluid that was just drained from his knee:
"I think it stems from me starting so fast and not having a chance to get a chance to practice and stuff, and not doing any running, just not playing over a month and jumping right into the fire. Hopefully, that's what it's from. I guess as much as I play, I guess it will go away, hopefully."
Of course, for a basketball player, it's never the worst thing to follow in the footsteps of the best player who ever played. But that doesn't mean it's the best, either.

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Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in... - PubMed - NCBI
1 selected item: 26936506
Karuppagounder SS1, Alim I1, Khim SJ1, Bourassa MW1, Sleiman SF1, John R2, Thinnes CC3, Yeh TL3, Demetriades M3, Neitemeier S4, Cruz D5, Gazaryan I1, Killilea DW6, Morgenstern L7, Xi G8, Keep RF8, Schallert T9, Tappero RV10, Zhong J1, Cho S1, Maxfield FR5, Holman TR11, Culmsee C4, Fong GH12, Su Y13, Ming GL13, Song H13, Cave JW1, Schofield CJ3, Colbourne F2, Coppola G14, Ratan RR15.
Children's Hospital of Oakland, Oakland, CA 94609, USA.
Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA. rrr2001@med.cornell.edu.
PMC5341138
HIF-PHD inhibitors stabilize HIF-1a and abrogate hemin- induced toxicity in rat primary neurons or immortalized neuroblasts independent of iron chelation. (A) DFO, an iron chelator/HIF-PHD inhibitor, blocks hemin-induced toxicity in rat primary cortical neurons (PN; median effective concentration (EC50), 34.1 mM], mouse hippocampal neuroblasts (HT22; EC50, 50.8 mM), and immortalized mouse striatal neuroblasts (Q7; EC50, 26.7 mM) as measured by MTT assay. (B) CPO, an HIF-PHD inhibitor distinct from DFO, abrogates hemin-induced toxicity in primary cortical neurons (EC50, 1.4 mM), hippocampal neuroblasts (EC50 0.9 mM), and immortalized striatal neuroblasts (EC50, 1.6 mM). (C) DHB, a distinct HIF-PHD inhibitor that does not bind to iron (), abrogates hemin-induced toxicity in primary cortical neurons (EC50, 34.9 mM), hippocampal neuroblasts (EC50, 86.7 mM), and immortalized striatal neuroblasts (EC50, 146.1 mM). (D to K) Representative images of live [calcein-AM, green] and dead (ethidium homodimer, red) primary cortical neurons treated with (D) saline, (E) DFO (100 mM), (F) CPO (3 mM), (G) DHB (100 mM), (H) hemin (50 mM), (I) hemin (50 mM) + DFO (100 mM), (J) hemin (50 mM) + CPO (3 mM), or (K) hemin (50 mM) + DHB (100 mM). Scale bar, 100 mm. (A to C) Significance was determined by two-way analysis of variance (ANOVA) followed by Bonferroni’s comparison test, from three independent experiments. (L) DFO, DHB, and CPO stabilize HIF-1a protein in mouse primary neurons. (M) CPO (3 mM) prevents hemin-induced neuronal death, but a CPO analog (3 mM, 5342; ) without PHD inhibitory activity does not. n.s., not significant. (N) Protection by CPO is not associated with significant reductions in total iron as measured by ICP-OES. (O to R) Live/Dead staining images of cells treated with (O) saline, (P) hemin (50 mM), (Q) hemin (50 mM) + CPO (1 mM), or (R) hemin (50 mM) + CPO analog (3 mM) in mouse hippocampal neuroblasts. Scale bar, 100 mm. One-way ANOVA followed by Dunnett’s comparison test, from triplicates (M and N) All graphs show the means ± SEM. Immunoblot data are representative of three experiments.
Sci Transl Med. ;8(328):328ra29-328ra29.
Molecular reduction of HIF-PHD isoforms in the mouse striatum enhances functional recovery after ICH. (A and B) Scheme for validating AAV8-Cre activity and selective deletion of PHD1, PHD2, and PHD3. KO, knockout. (C) Effective recombination by injection of AAV8-Cre into the mouse striatum was verified using a tdTomato floxed reporter. (D) Coronal sections of the tdTomato mouse brain revealed that tdTomato reporter expression was highest mediolaterally at coordinates corresponding to subsequent hemorrhagic stroke. Scale bars, 1 mm (C); 100 mm (D) (E) Quantitative PCR confirmed reduction of PHD1, PHD2, and PHD3 expression in the striatum of AAV8-Cre– injected mice but not in the striatum of AAV8-GFP–injected mice (E). (F) Quantitative PCR confirmed that reduction of striatal PHD expression led to increases in the HIF- dependent genes encoding VEGF and EPO in the mouse striatum. (G and H) Conditional reduction of HIF-PHDs enhances functional recovery in mice after ICH, as shown by two behavioral tasks: the corner task (G) and the tape removal task (H). Significance was determined by two-tailed t test (E and F) or two-way ANOVA with Bonferroni’s post hoc test (G and H). All graphs show the means ± SEM
Adaptaquin is an HIF-PHD inhibitor that can penetrate the mouse CNS. (A) In silico modeling predicts that adaptaquin (yellow) fits into the active site of HIF-PHDs. (B) Effect of adaptaquin on hydroxylation of a synthetic HIF peptide by recombinant HIF- PHD2, as assayed by mass spectrometry. (C and D) Adaptaquin dose-dependently inhibits HIF-PHD activity in the mouse brain as monitored by in vivo bioluminescence imaging from dorsal (C) and ventral (D) views. (E and F) Quantitative luciferase activity measurements (from pseudocolored bioluminescence) show that adaptaquin (AQ) increased the stability of ODD-luciferase in the brain and liver. (G) Increased ODD-luciferase activity in the brain was associated with increased transcription of p21waf1/cip1, a gene induced by neuronal HIF-PHD inhibition. (H) Analysis of lysates from several mouse brain regions showed an increase in ODD-luciferase reporter activity at 0, 6, 12, and 24 hours after intraperitoneal injection of adaptaquin (30 mg/kg). (I) Similar results were seen in the kidney and liver. Significance was determined by one-way ANOVA followed by Dunnett’s comparison test for vehicle compared to adaptaquin (10 or 30 mg/kg) treatment (E and F) or by two-way ANOVA with Bonferroni’s post hoc test (G to I). All graphs shows the means ± SEM.
Adaptaquin delivered after injury reduces cell death and enhances functional recovery in rodent models of ICH. (A) Experimental design for delivery of adaptaquin after ICH in mice. (B) Adaptaquin chemical structure. o.d., once daily. (C and D) Adaptaquin improved behavioral deficits associated with ICH in mice undertaking two sensory tasks: the corner task (C) and the tape removal task (D). (E to G) Adaptaquin reduced neuronal degeneration as monitored by Fluoro-Jade staining (green) in the perihematomal regions of the mouse brain. Scale bar, 100 μm. White arrows highlight degenerating neurons in the ICH group (F); this was reduced by adaptaquin treatment (G). (H and I) Stereological counting of Fluoro-Jade–positive neurons confirmed that adaptaquin treatment decreased the number of degenerating neurons in the hematoma (H) and perihematoma (I) regions. Veh, vehicle. (J) Diagram illustrating adaptaquin (30 mg/kg intraperitoneally) treatment in the rat autologous blood infusion model of ICH. (K) Adaptaquin improved single-pellet reaching in rats for up to 1 month after ICH. (L) Protocol for evaluating the total concentration of iron and zinc in the mouse brain after ICH and treatment with either vehicle or adaptaquin (30 mg/kg intraperitoneally). (M) Pseudocolored brain coronal sections from mice treated with collagenase to induce ICH. (N and O) Seven days after adaptaquin treatment, total iron (N) and zinc (O) concentrations were unchanged in the mouse CNS. Significance was determined by one-way ANOVA followed by Dunnett’s comparison test for vehicle or adaptaquin treatment after ICH (H to K) or by two-way ANOVA with Bonferroni’s post hoc test (C and D). All graphs show the means ± SEM.
Adaptaquin prevents neuronal death by suppressing ATF4- mediated expression of prodeath genes. (A) Adaptaquin dose- dependently protects mouse primary cortical neurons after treatment with the glutamate analog HCA. (B) Adaptaquin (1 mM) provides complete protection for 16 hours after HCA treatment. (C) Adaptaquin- mediated protection from HCA-induced oxidative stress as shown by Live/Dead imaging, Scale bar, 100mm. (D) Heat map showing the top 1000 differentially expressed genes. Shades of red represent up-regulation and shades of green represent down-regulation of gene expression. A subset of genes dysregulated by HCA treatment are corrected after treatment with adaptaquin. (E) Proportion of oxidative stress–related genes (left) whose expression was altered to more normal levels after treatment with 0.1 mM (middle) and 1 mM (right) adaptaquin. Overrepresented GO gene categories whose expression was altered by adaptaquin. (F) Overrepresented categories included genes involved in amino acid transport and regulation of programmed cell death. (G) The table shows the microarray data for ATF4-regulated genes induced by HCA and down-regulated by protective, but not by nonprotective, concentrations of adaptaquin. Values were transformed to log2 scale. (H to J) Quantitative PCR confirmed that the ATF4 target genes Trib3 (H), MTHFD2 (I), and STC2 (J) were induced by oxidative stress, and this induction was reduced by adaptaquin (1 mM). (K and L) Up-regulation of ATF4 immunostaining 7 days after ICH. ATF4 expression is shown in red, neurons are indicated by NeuN expression (green), and nuclei are stained with 4′,6-diamidino-2-phenylindole (blue). Significance was determined by two-way ANOVA followed by Bonferroni’s comparison test from three independent experiments (A) or by one-way ANOVA followed by Dunnett’s comparison test from triplicates (B and H to J). All graphs show the means ± SEM.
Adaptaquin inhibits ATF4 DNA binding, ATF4 transcriptional activity, and ATF4 prodeath properties in neurons. (A) HCA-induced oxidative stress up-regulated the promoter of the ATF4 target gene Trib3; this was blocked by adaptaquin (1 mM). Treatment with nonprotective concentrations of adaptaquin (0.1 mM) or an inactive oxyquinoline analog (compound 10, 1 mM) did not impede oxidative stress– induced activation of the Trib3 promoter-luciferase reporter construct. WT, wild type. (B) Mutation of the ATF4-binding site occludes oxidative stress inducibility and sensitivity to adaptaquin (1 mM). MUT, mutant. (C) ChIP studies showed that HCA-mediated oxidative stress increased ATF4 occupancy on the Trib3 promoter, which was blocked by protective concentrations of adaptaquin (1 mM). IgG, immunoglobulin G. (D to L) MTT assay (D) or Live/Dead staining (E to L) demonstrated that overexpression of ATF4 was sufficient to induce neuronal death in the absence of HCA, whereas protective concentrations of adaptaquin (1 mM) mitigated death by ATF4 overexpression or HCA and ATF4 overexpression. (M) Proline residues mutated to alanine residues in the mouse ATF4- 5P/A mutant construct are highlighted in red. (N) ATF4- 5P/A mutant does not induce cell death. (O) Adaptaquin inhibited hydroxylation of ATF4. (P) In mouse neurons, treatment with adaptaquin dose-dependently stabilized HIF-1a. (Q) Adaptaquin stabilization of HIF-1a (red line) occurs at concentrations higher than those required for full protection from oxidative death (red line). Significance was determined by two-way ANOVA followed by Bonferroni’s comparison test from three independent experiments (A, B, D, and N) or by one-way ANOVA followed by Dunnett’s comparison test from triplicates (C). All graphs show the means ± SEM.
Reduction of HIF-PHD isoforms in the mouse striatum reduces ICH-induced ATF4-dependent gene expression. (A to G) Expression of WT ATF4 (red), but not of ATF4-5P/A mutant (blue), through adenoviral infection of primary cortical neurons leads to time-dependent induction of Trib3 (C), CHOP (D), ATF3 (E), MTHFD2 (F), and STC2 (G). ChIP studies (B) correlate increases in Trib3 gene expression induced by WT ATF4 with occupancy at the Trib3 promoter. (H) Diagram of experimental plan to determine whether reduction of HIF-PHD isoforms can abrogate ATF4-dependent gene expression in vivo. (I to M) Effects of molecular reduction of HIF-PHD isoforms on ICH-induced expression of Trib3 (I), CHOP (J), ATF3 (K), MTHFD2 (L), and STC2 (M). Significance was determined by two-way ANOVA followed by Bonferroni’s comparison test from three independent experiments (B to G) or by one-way ANOVA followed by Dunnett’s comparison test (I to M). All graphs show the means ± SEM.
Adaptaquin inhibition of ATF4- dependent gene expression defines a therapeutic window after ICH. (A) Schematic of experimental plan to examine the effect of adaptaquin on ICH-induced Trib3 expression. (B) Immunoblots of ATF4 from nuclear extracts of the mouse striatum in distinct treatment groups. (C) Quantitative PCR of Trib3 message. (D) Immunoblots of Trib3 protein. (E to G) We examined the effect of adaptaquin (30 mg/kg) delivered 6 hours after collagenase injection and then daily for 7 days on ICH-induced spatial neglect in the corner task (F) or sensory neglect in the tape removal task (G). Significance was determined by oneway ANOVA followed by Dunnett’s comparison test (C) or by two-way ANOVA with Bonferroni’s post hoc test (F and G). All graphs show the means ± SEM
R01 EY022409/EY/NEI NIH HHS/United States
BBS/B/07683/Biotechnology and Biological Sciences Research Council/United Kingdom

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Patent US6144338 - Predictive drop and load algorithm for an object-based geographical ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA method and system are disclosed for providing a more accurate position of a mobile receiver even though a signal received by the mobile receiver indicating the position of the mobile receiver is inaccurate. The received signal is used as an estimated indication of the position of the mobile receiver....http://www.google.com/patents/US6144338?utm_source=gb-gplus-sharePatent US6144338 - Predictive drop and load algorithm for an object-based geographical information systemAdvanced Patent SearchPublication numberUS6144338 APublication typeGrantApplication numberUS 09/042,812Publication dateNov 7, 2000Filing dateMar 17, 1998Priority dateMar 17, 1998Fee statusPaidPublication number042812, 09042812, US 6144338 A, US 6144338A, US-A-6144338, US6144338 A, US6144338AInventorsFrederick Bryan DaviesOriginal AssigneePrc Public Sector. Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (21), Non-Patent Citations (16), Referenced by (93), Classifications (9), Legal Events (6) External Links: USPTO, USPTO Assignment, EspacenetPredictive drop and load algorithm for an object-based geographical information system
9. A method, comprising the steps of:receiving a signal at a mobile receiver; calculating an estimation of the current position of the mobile receiver based upon the received signal; accessing one object-based database comprising geometrical objects representing topological features and navigable routes, each geometrical object comprising a tessellation identifier attribute and a geometry attribute defining the geometry of a complete representation of the topological feature or navigable route, the topology being divided into a plurality of tessellations; determining a probable geometrical object representing a navigable route where the mobile receiver is probably located and determining a tessellation associated with the determined geometrical object; fetching geometrical objects having a tessellation identifier attribute associated with the determined tessellation from the one database and geometrical objects associated with three additional tessellations adjacent to the determined tessellation wherein the four fetched tessellations form a 2�2 array; loading the fetched geometrical objects into a virtual blackboard; comparing the estimated position of the mobile receiver to the probable geometrical object representing a navigable route and if the estimated position differs from a position coinciding with a portion of the probable geometrical object, adjusting the estimated position to a probable position coinciding with a portion of the probable geometrical object; drawing topological features using the fetched geometrical objects and drawing a representation of the mobile receiver in the probable position on the display; and continually determining the probable position of the mobile receiver and as the mobile receiver changes its probable position and crosses a boundary between the determined tessellation and an unloaded adjacent tessellation and performing the further steps of: unloading two of the loaded tessellations from the virtual blackboard; fetching geometrical objects having a tessellation identifier associated with two additional unloaded tessellations adjacent to the determined tessellation; loading the fetched geometrical objects of the two additional tessellations into the virtual blackboard, one of which is the tessellation in which the mobile receiver is located; drawing topological features using the fetched geometrical objects of the loaded adjacent tessellation in which the mobile receiver is located and drawing a representation of the mobile receiver in the probable position on the display. 10. A method, comprising the steps of:receiving a signal at a mobile receiver; calculating an estimation of the current position of the mobile receiver based upon the received signal; accessing one object-based database comprising geometrical objects representing topological features and navigable routes, each geometrical object comprising a tessellation identifier attribute and a geometry attribute defining the geometry of a complete representation of the topological feature or navigable route, the topology being divided into a plurality of tessellations; determining a probable geometrical object representing a navigable route where the mobile receiver is probably located and determining a tessellation associated with the determined geometrical object; fetching geometrical objects having a tessellation identifier attribute associated with the determined tessellation from the one database; comparing the estimated position of the mobile receiver to the probable geometrical object representing a navigable route and if the estimated position differs from a position coinciding with a portion of the probable geometrical object, adjusting the estimated position to a probable position coinciding with a portion of the probable geometrical object; and drawing topological features using the fetched geometrical objects and drawing a representation of the mobile receiver in the probable position on the display. 11. The method of claim 10, wherein said signal comprises a plurality of GPS satellite signals wherein each of the signals includes errors to reduce the position accuracy of each of the signals and wherein the mobile receiver is a GPS receiver.
15. The method of claim 10, further comprising the step of fetching geometrical objects having a tessellation identifier associated with three additional tessellations adjacent to the determined tessellation wherein the four fetched tessellations form a 2�2 array.
The third problem concerns the precision and accuracy of the signals received from GPS satellites. This problem is addressed in this patent application. By way of explanation, the following background is provided regarding GPS satellite systems. Since the early 1980's the Global Positioning System (GPS) satellite system has been utilized. This system will eventually comprise a large number of satellites in orbits approximately 11,000 miles above the earth's surface inclined about 55� from the equatorial plane. The satellites are not at a constant position but have a twelve hour orbit. At any point on the earth a ground based receiver can normally receive signals from at least four GPS satellites. A basic explanation of GPS and its use in surveying is given in Hurn. "GPS, A Guide to the Next Utility," Trimble Navigation, 1989, incorporated herein by reference thereto.
In another aspect of the invention, a method is disclosed including the step of receiving a signal at a mobile receiver and calculating an estimation of the current position of the mobile receiver based upon the received signal. An object-based database is accessed comprising geometrical objects representing topological features and navigable routes where each geometrical object comprises a tessellation identifier attribute and a geometry attribute defining the geometry of a complete representation of the topological feature or navigable route. The topology is divided into a plurality of tessellations. A probable geometrical object is determined representing a navigable route where the mobile receiver is probably located. A tessellation associated with the determined geometrical object is determined. Geometrical objects are fetched having a tessellation identifier attribute associated with the determined tessellation from the one database and geometrical objects associated with three additional tessellations adjacent to the determined tessellation wherein the four fetched tessellations form a 2�2 array. The fetched geometrical objects are loaded into a virtual blackboard. The estimated position of the mobile receiver is compared to the probable geometrical object representing a navigable route and if the estimated position differs from a position coinciding with a portion of the probable geometrical object, the estimated position is adjusted to a probable position coinciding with a portion of the probable geometrical object. The topological features are drawn using the fetched geometrical objects and a representation of the mobile receiver is drawn in the probable position on the display. The probable position of the mobile receiver is continually determined as the mobile receiver changes its probable position and crosses a boundary between the determined tessellation and an unloaded adjacent tessellation. Two of the loaded tessellations are unloaded from the virtual blackboard. Geometrical objects are fetched having a tessellation identifier associated with two additional unloaded tessellations adjacent to the determined tessellation. The fetched geometrical objects of the two additional tessellations are loaded into the virtual blackboard, one of which is the tessellation in which the mobile receiver is located. The topological features are drawn using the fetched geometrical objects of the loaded adjacent tessellation in which the mobile receiver is located. A representation of the mobile receiver is drawn in the probable position on the display.
FIG. 5A is an illustration of four tiles forming a 2�2 array loaded into a virtual blackboard;
Referring back to the block diagram architecture of FIG. 2, and to the diagram of FIG. 3, the present invention can best be explained by way of examples. In a first example depicted in FIGS. 5A-C, let us assume that an aircraft is flying along air route corridor W and the GIS system 20 is turned on at time t1. GPS antenna 22 receives a plurality of satellite signals from satellites 26, 28, 30 wherein errors are deliberately introduced into the satellite signals to reduce the position accuracy of unauthorized GPS users. The GPS receiver 24 then calculates an estimation of the current position of the mobile GPS receiver 24 based upon the plurality of GPS signals and outputs this current estimated position to the processor 104. A representation of this estimation is depicted in FIGS. 3 and 5A as t1e. The estimated positions are being shown in FIGS. 3 and 5A for illustrative purposes. The processor 104 then, using the signal of the current estimated position, determines which tile the aircraft is currently in and then accesses databases 304, 306 and loads entries associated with tiles A, B, C and D including navigational routes W and X into the virtual blackboard 342 as illustrated in FIG. 5A. In this example, up to four tiles can be loaded into the virtual blackboard 342 at any time and form a 2�2 array. It should be understood that for illustrative purposes the virtual blackboard 342 is being illustrated as a graphical display although the virtual blackboard is not really a display but rather a memory area in the processor 104. Because the processor 104 determined that he aircraft is located in tile D, the accessed geometrical objects associated with tile D are displayed on the screen display 112 as depicted in FIG. 5B. The estimated positions are not displayed on the screen display 112.
The processor 104 causes tiles A and C to be dropped from the virtual blackboard 342 and tiles G and H added to the virtual blackboard 342 to form a new 2�2 array as depicted in FIG. 6C. The screen display 112 then scrolls to display tile H as depicted in FIG. 6D along with the mobile receiver 24 at position t6p.
The present invention provides a method and apparatus for predictive dropping and loading entries associated with the tiles from the virtual blackboard 342 so that the topology or navigational routes can be displayed in real time. Tiles are always stored in the virtual blackboard 342 in a 2�2 array and only two tiles are dropped and loaded at any one time. Thus, a difficulty can arise should the GPS receiver be moving at precisely a 45� angle toward a corner such as the intersection of the boundaries of tile D, F, H, I. In this situation, referring back to FIG. 3, it is possible that the automobile could drive directly from tile D to tile I.
Another embodiment is depicted in FIG. 7 which utilizes nine tiles J, K, L, M, N, O, P, Q, R in loaded into the virtual blackboard 342 in a 3�3 array. In this embodiment the position of the GPS receiver on the screen display 112 is always maintained in the center, for example, in tile N. This embodiment is advantageous over the previously described 2�2 array because the next adjacent tile is always loaded into the virtual blackboard 342. Thus, if an aircraft were flying from tile N directly into tile R, five tiles L, K, J, M, P would be dropped and tiles S, T, U, V, AA added to the virtual blackboard. The difficulty with this embodiment, as can be appreciated, is that it takes more time and memory to drop and load five tiles instead of two.
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G01S1/00Cooperative ClassificationG01C21/20, G01S5/0072, G01S19/40European ClassificationG01S19/40, G01C21/20Legal EventsDateCodeEventDescriptionOct 23, 1998ASAssignmentOwner name: PRC PUBLIC SECTOR, INC., VIRGINIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DAVIES, FREDERICK BRYAN;REEL/FRAME:009533/0853Effective date: 19981022May 7, 2004FPAYFee paymentYear of fee payment: 4May 6, 2008FPAYFee paymentYear of fee payment: 8Nov 30, 2009ASAssignmentOwner name: NORTHROP GRUMMAN INFORMATION TECHNOLOGY, INC., CALFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:NORTHROP GRUMMAN CORPORATION;REEL/FRAME:023574/0761Effective date: 20091125Owner name: NORTHROP GRUMMAN INFORMATION TECHNOLOGY, INC.,CALIFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:NORTHROP GRUMMAN CORPORATION;REEL/FRAME:023574/0761Effective date: 20091125Feb 10, 2010ASAssignmentOwner name: NORTHROP GRUMMAN SYSTEMS CORPORATION,CALIFORNIAFree format text: ASSIGNMENT OF ASSIGNORS 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History of Suicide: Voluntary Death in Western Culture (Medicine and Culture): Mr. Georges Minois, Ms. Lydia G. Cochrane: 9780801859199: Amazon.com: Books
Mr. Georges Minois (Author), Ms. Lydia G. Cochrane (Translator)
In this compact and illuminating history, Georges Minois examines how a culture's attitudes about suicide reflect its larger beliefs and values--attitudes toward life and death, duty and honor, pain and pleasure. Minois begins his survey with classical Greece and Rome, where suicide was acceptable--even heroic--under some circumstances. With the rise of Christianity, however, suicide was unequivocally condemned as self-murder and an insult to God. With the Renaissance and its renewed interest in classical culture, suicide reemerged as a philosophical issue. Minois finds examples of changing attitudes in key Renaissance texts by Bacon, Montaigne, Sidney, Donne, and Shakespeare.By 1700, the term suicide had replaced self-murder and the subject began to interest the emerging scientific disciplines. Minois follows the ongoing evaluation of suicide through the Enlightenment and the Romantic periods, and he examines attitudes that emerge in nineteenth- and twentieth-century science, law, philosophy, and literature. Minois concludes with comments on the most recent turn in this long and complex history -- the emotional debate over euthanasia, assisted suicide, and the right to die.
John WeaverPaperback$33.95 Prime
Suicide, or "self murder," was viewed as an honorable death in ancient times. By the high Middle Ages, however, the corpses of suicides were mutilated and buried in unconsecrated grounds. Now, of course, terms like Kevorkian (sometimes used as a verb!) and assisted death have become part of an ongoing national debate. Minois, the author of numerous books on religious attitudes and relations with secular society, has provided a timely chronicle tracing the evolution of societal attitudes toward suicide. He utilizes such diverse sources as St. Augustine, Shakespeare, and Camus. Minois writes in an unadorned, concise prose that aids him in treating a serious subject in a serious manner. Although his own convictions on the issue are clear, Minois treats both sides of our current debate with objectivity, understanding, and compassion. Jay Freeman
Minois's book follows the religious, philosophical, literary, and judicial debate for and against self-murder from antiquity to the end of the Enlightenment, demonstrating the close connection between political power, religious authority, social s tatus, and the freedom to die. Minois, an independent scholar and author of 14 books, begins with the change in public attitudes toward suicide in Rome, in the face of military exigencies and a barbarian onslaught. The Epicurean ideal of the ``perfect exi t'' was rejected by a state desperate to increase the number of taxpayers and soldiers at its disposal. Suicide was punished by confiscation of the deceased's estate and destruction of the corpse. After the rise of Christendom, church leaders incorporated prohibitions on suicide into religious doctrine, in part through the philosophical translation of Thomas Aquinas. Medieval law followed suit, prescribing torture, hanging, public display, and ignominious disposal of the corpses of suicides. Not until the advent of scientific inquiry in the Renaissance were these rules challenged, but by then there was a double standard: commoners who hanged or drowned themselves were punished, while nobles who took their own lives with cold steel or pistols escaped ``jus tice'' through insanity rulings and purposely botched investigations. Most interesting is the link between power and suicide; whenever the political and religious establishment experienced weakening authority, official opposition to suicide increased. The Reformation, Enlightenment, and French Revolution all saw intensified propaganda against self-murder. The conclusion is clear, as is Minois's sympathy: suicide is the last refuge of the free man. Death, after all, is not only a land of no return, it is t he line delimiting the power of state and church. Minois's study is detailed and thorough, though he rarely leaves France and England for examples. It may be too thorough for the casual reader, but gory anecdotes and effective reference to overarching int ellectual trends make the book edifying and morbidly enjoyable. -- Copyright ©1998, Kirkus Associates, LP. All rights reserved.
ISBN-10: 0801859190
ISBN-13: 978-0801859199
Amazon Best Sellers Rank: #1,521,050 in Books (See Top 100 in Books)
I am doing my honours thesis on the representation of suicide in Shakespeare. This book is excellent for giving a comprehensive look at the history of suicide. It reads really well and is difficult to put down. For my own purposes, there was a lot of info on Shakespeare and it was really useful material. If you're not in the realm of needing the book for study, it would also be an excellent read for finding out more about a subject that although taboo, it is incredibly intriguing and interesting.
5.0 out of 5 starsHistory of Suicide: Voluntary Death in Western Culture
This book is a reference for those interested in studying Suicide and suicidal behavior. When studying a subject like this, everyone should start with the basics, i.e. historical reviews and perspectives of the phenomena. After reading this very well written book the reader will surely become more familiar with some of the basic thoughts pertaining suicide and its cultural, historical, and some light scientific perspectives of the suicidal phenomena. Everyone should read it, even for cultural enrichment. Webmaster.suicide@clix.pt


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1. Music Video Evaluation By James Cummings
2. CD Front CoverHere is my development stages that I have gone through to get to my Finalproduct. What I have tried to do is create a simple but effective CD Cover, I havelooked at artists such as Coldplay, The script etc to gain inspiration for my CDCover.What I have done is gone for a simple back ground but done a robot shadow kindof thing with different colours to catch the eyes of my audience. This isn’tsomething a normal artist does but that what I have tried to do and gounconventional for my type of genre which is good because my song choice isn’tnormal so this way I also have a link between my music video and CD Coverwhich I think the audience will really connect with. Stage 1 Stage 2 Final Product
3. CD Cover BackHere is my development stages that I have gone through to get to my Finalproduct. What I have tried to do is create a simple but effective Back CD Cover, Ihave looked at artists such as Coldplay, The script etc to gain inspiration for myBack CD Cover.What I have done is gone for a simple back ground but done a robot shadowkind of thing with different colours to catch the eyes of my audience. This isn’tsomething a normal artist does but that what I have tried to do and gounconventional for my type of genre which is good because my song choice isn’tnormal so this way I also have a link between my music video and Back CDCover which I think the audience will really connect with. Stage 1 Stage 2 Final Product
4. Inspiration for CD CoverHere is some of the CD Covers I looked at to give me inspiration for the CDCover I made. For Coldplay I looked at the way they have used differentcolours to create a figure, this is something I through looked really good everythough there isn’t something amazing but still stands out.I also looked at them all for the type of background they have to make sure thecolour figure I am going to create works, I have gone for a natural green colourwhich matches with mostly every colour to make the figure stand out. Myinspiration normally came from Coldplay however I have tried to go for alarger scale than Coldplay.
5. Andrew Goodwins TheoryHow to analyse a Music VideoAndrew Goodwins theory is all about how to analyse a music video. AndrewGoodwin identifies 5 Key aspects of any music video that we theaudience should look for when watching a music video.8. Thought beats – seeing the sounds9. Narrative and performances10. The Star Image11. Relation of visuals to song12. Technical aspects of music video
6. Thought beats – seeing the soundsAndrew Goodwin’s Theory believes there is three stages that through beats -seeing the sounds requires.Step One: The first step is to looks at the music itself. We must take into accountthe structure of the song. E.g. Intro, Verse, Pre-Chorus, Chorus etc.Step Two: The second step is the Voice of the song. The voice of the singer isextremely unique and can form a certain identity for the singer and can createtrademarks that work well with the stars image.Step Three: Goodwin points out the artists mode of address. Many songs suchlike Katy Perry “The one that got away” and Foo Fighters “Walk” can be seen as astory and the artist is the storyteller. This makes the music video a two waycommunication device, this way it tells us a story and a song.
7. Narrative and performancesSongs fail to give us the complete narrative.When listening to a song we only tend to get the gist of the meaning ofthe song and tend to make up are own idea of what the song is about bywhat we are told.Goodwin explains that music videos should ignore the commonnarrative. This is because it is important in their role of advertising.Music videos should coherent repeatability. Narrative and performancework hand in hand it makes it easier for the audience to watch over andover without losing interest.The artist acting as both narrator & participants helps to increaseauthenticity however the lip sync and other mimed actions remains theheart of the music video. This means the audience needs to believe it’sreal.
8. The Star ImageAndrew Goodwin’s third key aspect is the star image, The star image is a virtualaspect to any music video.A Mega narrative which is a big story that will describe the star over a period of timeand his/hers development as well. It has an important part to play in a music video, Ithink this is because it give the audience a person to connect with through the musicvideo and makes the video more interesting if you feel you know their past andmakes you believe you have gone through everything they have gone through withthem.
9. Relation of visuals to song There are three ways in which music videos work to promote the song.Illustrate – Music videos can use a set of images to illustrate themeanings of lyrics and genre, this is the most common.Amplify – This is similar to repeatability. Meanings and effects aremanipulated and constantly shown through the video and drummed into ourvision.Disjuncture – This is where the meaning of the song is completelyignored.
10. Technical aspects of music videoTechnical aspects hols the music video together through use of camerawork, movement, mise – on –scene, sound, editing etc.Speed, camera movements, editing, cutting and post productions are allforms of use of camera. Lighting and colours according to AndrewGoodwin helps set the mood e.g. dark lighting will set a depressed,upsetting scene. It also emphasising key moments of the song anddramatic effects.Mise-on-Scene, the settings of music videos is vital, it needs to lookauthentic to attain professionalism. Beats, music videos cuts to go withthe beats or rhythm making the video more entertaining.
11. How my Music Video compares to Andrew Goodwins theory.The star Image in my Music VideoBecause I have three singers in my music video I have had to give each ofmy singers a spot to shine in the music video. I have separated the songso that each person get a chance to have a star image. Andrew Goodwinbelieves that each music video has a star image and can create a story ofthe star.However, mine does really do that because we are just making fun ofsomething, this however is showing three guys having fun really. Youalso don’t see the characters develop over time until the ending whenyou see them all together at the end playing and ending the song.
12. In what way does your media product use, develop or challenge forms and conventions of real media products.In my music video I have tried to challenge the normal conventions and also Ihave tried to do a spoof of the normal white background boy band style thatevery normal American band. I have not done the conventional approach andmoved from different scenes and seen loads of different people and overexaggeration that story what my music video has done is done a spoof aboutthat all of that and just shown me, lee and Ryan having a laugh. This issomething that my target audience will hopefully connect with because theyhave all thought of this but we are actually showing them what they havethought of for years.However, my Music video has also developed the normal conventions of a boyband doing a music video that means something, my music video is showing astory of three lads that find song funny, this is kind of following the conventionthat a boy band again is telling their target audience a story.I have also used conventions such as the same type of camera shots, and slowmotion shot which typical music videos of my genre use, I thought this isimportant to use purely because I felt if I go too unconventional it make look tocheesy or abit stupid and may put my target audience off.
13. How effective is the combination of your main product and ancillary texts? Products On my media products such as CD Covers, Back of the CD Cover, The actual CD and the poster. I have made sure that the name of my band and the title of the album is one every single of them. This makes all my products joined together. All of these products have had the same type of theme green background and colored figures. This is a theme that I have wanted to continue the whole the way through the products. For the fonts on my product I have tired to keep the same fonts through most of my products this way I will be have a connection all the way through to products and hopefully people notice. The background of my products are all low lighting dark colours I have done this for a reason and it is to make whatever else is bright stand out more and make my products more eye catching. The colour scheme I have really thought about and on all my products such as CD Covers, CD Back Cover and the CD I have kept the same background so it again make a connection through the whole products.
14. How effective is the combination of your mainproduct and ancillary texts? Continued ......Music VideoOn my music video I have kept the location really in about three locationsonly to the fact that on most American boy bands they normally stay in oneplace so what I have tried to do is take the fun of it and do the same but do itwrong. This is something that I think works.At the beginning of the music video I have put the title and the name of thesong at the beginning. Most music videos do this it creates a link between allof your products and helps the audience recognize the music video.
15. What have you learned from your audience feedback?Katie McDonald : “It’s funny but needs to be in more places”Emma Bailey: “Made me laugh but needs more locations”Ryan Bedson: “I like it just needs more things going on, but other thanthat very funny”Ryan Gittins: “Mostly in one place but yeah its good”Most of my feed back from my friends and media class mates are that Ineed more locations in my music video. During my music video I havestayed in two – three locations but that is purely because I am trying tomake the fun out of the American music videos.If I had more time I would probably research loads more American boyband videos and probably trying to make my music video and a newway of adding new clips to the music video and listen to my feedback.
16. How did you see media technologies in the construction and research, planning and evaluation stages?I have used Windows 7 version of Windows movie maker. I havechosen to use this program because I have experience on thisprogram and didn’t want to waste time getting use to theprogram when I could use windows. This may not offer as muchas and iMac which other people may use but I found this easierfor me.Windows Movie maker also was helpful for me when I wascreating a storyboard for my music video because you can set itas a storyboard style which allows me to put pictures on thereand I can see easier how my music video would go and if itwould work I found this easier than writing it out or drawing itout on paper.
17. How did you use media technologies in theconstruction and research, planning andevaluation stages? Continued …….Other programs that I have used is Microsoft PowerPoint and Microsoft Wordwhich I used at different stages of the project. I used PowerPoint when I wasresearching to create a PowerPoint showing my how I have got my inspirationfor most of my products.I also used Microsoft Word to create questioners and used it to write downfeedback. Both were very useful through out my project.I have also used firework to create all my products. I used this so I could createAncillary texts through out my work. I then also used fireworks to make thingsbold and stand out.

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BBC News - How does the oldest grand piano sound?
Last updated at 08:50 Help	The oldest-surviving English grand piano, one of the first ever made, was built by the piano maker Americus Backers in London in 1772 and has now been returned by English Heritage to the home of its former owner, the Duke of Wellington. The Today programme's reporter Tom Bateman went to hear it being played by Pianist and composer Professor David Owen Norris.
You can can find out more about the piano in concert on the English Heritage website.

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text:
Diners puff on cigarettes at a restaurant in Chigasaki, Japan. Tighter regulations on where smokers can light up and higher costs are pushing many to quit.Credit...Tyler Sipe for The New York Times
TOKYO  When the Japanese government raised the tax on cigarettes on Oct. 1, it could have started a public health revolution in this land of heavy smokers.
Japan has long been a smokers’ stronghold. Cheap cigarettes sold by a government-controlled tobacco company and lax antismoking laws  smokers have almost total freedom to light up at bars, restaurants and even schools and government offices  have long encouraged the habit. About 130,000 people a year die of tobacco-related illnesses in Japan, according to the World Health Organization.
But a growing health consciousness, tighter regulations on tobacco advertising and increasingly strict smoking bans on public transport have contributed to a gradual decline in smoking. The smoking rate for men was 36.6 percent in 2010, 2.3 percentage points lower than a year earlier  though far above the 24 percent smoking rate among men in the United States.

value: This website is an American daily newspaper based in New York City with a worldwide readership. Founded in 1851, the Times has since won 132 Pulitzer Prizes, the most of any newspaper, and has long been regarded within the industry as a national "newspaper of record".