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Winnie the Pooh & the blustery day (VHS tape, 1985) [WorldCat.org]
http://www.worldcat.org/oclc/27927712
Title: Winnie the Pooh & the blustery day
Author: A A Milne; Disney Educational Productions; Coronet/MTI Film and Video
Publisher: Burbank, Calif. : Northbrook, Ill. : Disney Educational Productions ; Distributed by Coronet/MTI Film & Video, [1990?]
OCLC:27927712
A A Milne; Disney Educational Productions.; Coronet/MTI Film and Video.
Burbank, Calif. : Disney Educational Productions ; Northbrook, Ill. : Distributed by Coronet/MTI Film & Video, [1990?]
A blustery wind sweeps through the Hundred Acre Wood, toppling Owl's tree home, and making everyone, especially Pooh, very uneasy.
Based on the stories of A.A. Milne.Videocassette release of the 1965 motion picture.
Story by Larry Clemmons, Ralph Wright, Julius Svendsen, Vanre Gerry ; music and lyrics by Richard M. Sherman and Robert B. Sherman ; scored and conducted by Buddy Baker ; directed by Wolfgang Reitherman.
Paul Winchell, Jon Walmsley, John Piedle, Sterling Hollowsy, Howard Morris, Junius C. Matthew, Ralph Wright, Hal Smith, Barbara Luddy, Clint Howard, Sebastian Cabot.
1 videocassette (VHS) (25:50 min.) : sound ; 1/2 in. + 1 teachers guide.
Add tags for "Winnie the Pooh & the blustery day".
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library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/3943819005#Place/northbrook_ill> ; # Northbrook, Ill.
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schema:publisher <http://experiment.worldcat.org/entity/work/data/3943819005#Agent/distributed_by_coronet_mti_film_&_video> ; # Distributed by Coronet/MTI Film & Video
wdrs:describedby <http://www.worldcat.org/title/-/oclc/27927712> ; .
<http://experiment.worldcat.org/entity/work/data/3943819005#Agent/disney_educational_productions> # Disney Educational Productions
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<http://experiment.worldcat.org/entity/work/data/3943819005#CreativeWork/winnie_the_pooh> # Winnie-the-Pooh.
a schema:CreativeWork ; schema:creator <http://experiment.worldcat.org/entity/work/data/3943819005#Person/milne_a_a_alan_alexander_1882_1956> ; # Alan Alexander Milne
<http://experiment.worldcat.org/entity/work/data/3943819005#Person/milne_a_a_alan_alexander_1882_1956> # Alan Alexander Milne
<http://experiment.worldcat.org/entity/work/data/3943819005#Person/winnie_the_pooh_fictitious_character> # (Fictitious character) Winnie-the-Pooh
<http://experiment.worldcat.org/entity/work/data/3943819005#Place/burbank_calif> # Burbank, Calif.
<http://experiment.worldcat.org/entity/work/data/3943819005#Place/northbrook_ill> # Northbrook, Ill.
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a bgn:PublicationSeries ; schema:hasPart <http://www.worldcat.org/oclc/27927712> ; # Winnie the Pooh & the blustery day
schema:name "Winnie the Pooh series." ; schema:name "Winnie the Pooh series" ; .
a schema:Organization ; schema:name "Coronet/MTI Film and Video." ; .
<http://www.worldcat.org/title/-/oclc/27927712> a genont:InformationResource, genont:ContentTypeGenericResource ; schema:about <http://www.worldcat.org/oclc/27927712> ; # Winnie the Pooh & the blustery day
<http://www.worldcat.org/title/-/oclc/27927712#PublicationEvent/burbank_calif_disney_educational_productions_northbrook_ill_distributed_by_coronet_mti_film_&_video_1990> a schema:PublicationEvent ; schema:location <http://experiment.worldcat.org/entity/work/data/3943819005#Place/northbrook_ill> ; # Northbrook, Ill.
schema:location <http://experiment.worldcat.org/entity/work/data/3943819005#Place/burbank_calif> ; # Burbank, Calif.
schema:organizer <http://experiment.worldcat.org/entity/work/data/3943819005#Agent/distributed_by_coronet_mti_film_&_video> ; # Distributed by Coronet/MTI Film & Video
schema:organizer <http://experiment.worldcat.org/entity/work/data/3943819005#Agent/disney_educational_productions> ; # Disney Educational Productions
Winnie the Pooh & the blustery day/A A Milne; Disney Educational Productions.; Coronet/MTI Film and Video.;; Burbank, Calif. : Disney Educational Productions ; Northbrook, Ill. : Distributed by Coronet/MTI Film & Video, [1990?]

value: This website is a union catalog that itemizes the collections of 15,637 libraries in 107 countries that participate in the OCLC global cooperative. It is operated by OCLC, Inc.


text:
duncdog10 comments on How to keep an idiot busyjump to contentmy subredditsannouncementsArtAskRedditaskscienceawwblogbookscreepydataisbeautifulDIYDocumentariesEarthPornexplainlikeimfiveFitnessfoodfunnyFuturologygadgetsgamingGetMotivatedgifshistoryIAmAInternetIsBeautifulJokesLifeProTipslistentothismildlyinterestingmoviesMusicnewsnosleepnottheonionOldSchoolCoolpersonalfinancephilosophyphotoshopbattlespicsscienceShowerthoughtsspacesportstelevisiontifutodayilearnedTwoXChromosomesUpliftingNewsvideosworldnewsWritingPromptsedit subscriptionsfront-all-random | Fitness-tifu-science-creepy-Documentaries-DIY-InternetIsBeautiful-news-gifs-Music-IAmA-worldnews-funny-nosleep-gaming-pics-history-Futurology-photoshopbattles-books-food-videos-movies-askscience-listentothis-LifeProTips-sports-television-UpliftingNews-personalfinance-nottheonion-GetMotivated-mildlyinteresting-gadgets-philosophy-aww-dataisbeautiful-EarthPorn-space-WritingPrompts-Jokes-TwoXChromosomes-Showerthoughts-explainlikeimfive-OldSchoolCool-todayilearned-AskReddit-Artmore » funnycommentsrelatedother discussions (1)want to join? sign in or create an account in seconds|Englishlimit my search to /r/funnyuse the following search parameters to narrow your results:subreddit:subredditfind submissions in "subreddit"author:usernamefind submissions by "username"site:example.comfind submissions from "example.com"url:textsearch for "text" in urlselftext:textsearch for "text" in self post contentsself:yes (or self:no)include (or exclude) self postsnsfw:yes (or nsfw:no)include (or exclude) results marked as NSFWe.g. subreddit:aww site:imgur.com dogsee the search faq for details.advanced search: by author, subreddit...this post was submitted on 02 Nov 2011383 points (82% upvoted)shortlink: remember mereset passwordloginSubmit a humorous linkSubmit a comical text postfunnyunsubscribesubscribe8,215,356 readers17,896 users here nowWelcome to r/Funny:
a community for 7 yearsmessage the moderatorsMODERATORSilluminatedwaxWe're no strangerskrispykrackersKyldeThe JanitorGuitarFreak027brownboy13There is no alien, citizen.complex_reductionLivykaLord_Nukeoh god how did this get here I am not good with computersKnowltey...and 16 more »382383384How to keep an idiot busy (i.imgur.com)submitted 3 years ago by ellinascy96 commentssharecancelsorry, this has been archived and can no longer be voted onloading...sorted by: besttopnewhotcontroversialoldrandomq&ayou are viewing a single comment's thread.view the rest of the comments →[–]duncdog10 0 points1 point2 points 3 years ago (0 children)sorry, this has been archived and can no longer be voted onParanormal 4?
permalinkembedaboutblogaboutteamsource codeadvertisejobshelpsite rulesFAQwikireddiquettetransparencycontact usapps & toolsAlien Blue iOS appreddit AMA appmobile sitebuttons<3reddit goldreddit storeredditgiftsreddit.tvradio redditUse of this site constitutes acceptance of our User Agreement and Privacy Policy. © 2015 reddit inc. All rights reserved.REDDIT and the ALIEN Logo are registered trademarks of reddit inc.create a new accountusername:password:verify password:email: (optional)remember mecreate accountsign inusername:password:remember mereset passwordsign inWe care about your privacy, and we never spam. By creating an account, you agree to reddit's User Agreement and Privacy Policy. We're proud of them, and you should read them.English [en]العربية [ar]Беларуская мова [be]български език [bg]Bosanski [bs]català [ca]česky [cs]dansk [da]Deutsch [de]Ελληνικά [el]English (Australia) [en-au]English (Canadian) [en-ca]English (Great Britain) [en-gb]English [en-us]Esperanto [eo]español [es]español [es-ar]eesti keel [et]Euskara [eu]فارسی [fa]suomi [fi]français [fr]Gàidhlig [gd]עברית [he]मानक हिन्दी [hi]hrvatski [hr]Magyar [hu]Հայերեն լեզու [hy]Bahasa Indonesia [id]íslenska [is] (*)italiano (Italy) [it]日本語 [ja]ಕನ್ನಡ [kn_IN]한국어 [ko]Latin [la]1337 [leet]LOL [lol]lietuvių kalba [lt]latviešu valoda [lv]Nederlands [nl]Nynorsk [nn]Norsk [no]Arrrrrrrr! [pir]polski [pl]português [pt] (*)português [pt-pt]português brasileiro [pt_BR]română [ro]русский [ru]slovenčina [sk]slovenščina [sl]српски језик [sr]Srpski [sr-la]Svenska [sv]தமிழ் [ta]ภาษาไทย [th]Türkçe [tr]українська мова [uk]Tiếng Việt [vi]中文 [zh] (*) incomplete volunteer to translateπ Rendered by PID 31936 on app-65 at 2015-03-30 14:13:31.966900+00:00 running 55d996a country code: US.

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text: Strong start for Big Ten, but finish means more2706dStrong start for Big Ten, but finish means moreEmailcommentSep 13, 2008ESPN.com EmailprintcommentPosted by ESPN.com's Adam RittenbergWEST LAFAYETTE, Ind. -- The real referendum on the Big Ten comes this afternoon and tonight, but the league avoided any setbacks in the early games. Michigan State's Javon Ringer can expect a helmet sticker in his future after rushing for 276 yards and two scores on 43 carries, but defense dominated in East Lansing and elsewhere in the early games.Michigan State, Iowa and Northwestern allowed a combined 10 points in victories. Spartans coach Mark Dantonio has to be thrilled with his defense, which underachieved earlier this year, and Iowa's looked solid protecting the red zone.Illinois should be a little worried after having to hang on against Louisiana-Lafayette. The defense struggled in the fourth quarter and Juice Williams couldn't find a passing rhythm in the rain. A 3-point win at home could knock the Illini out of the polls.Surprisingly, the sun is out here at Ross-Ade Stadium, but a strong wind is blowing to the northeast. Could be trouble for Curtis Painter and the Purdue offense. And there's still a chance for thunderstorms. Game-time temperature is 88 degrees (heat index of 92).I'm no fashion guru, but Oregon's road unis look chic: green pants, white jerseys and white helmets. It's certainly an upgrade from these eyesores. The Ducks coaches look a bit like crossing guards in their bright yellow shirts, but overall, not bad.The world's largest drum made its appearance with Purdue's marching band. Those guys with conquistador hats ran it around the field. A pretty funny sight.A couple of depth chart changes for Purdue:Senior Garrett Miller will start at left tackle with Zach Jones moving to the right side. Star tackle Sean Sester is expected to play.Sophomore Ryan Kerrigan will start at defensive end ahead of Gerald Gooden.

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Ponty taken to HC over food supply deal - Hindustan Times
home » India-news » UttarPradesh Ponty taken to HC over food supply deal
Rajesh Kumar Singh, Hindustan Times Allahabad, November 07, 2012
First Published: 23:57 IST(7/11/2012) | Last Updated: 01:48 IST(8/11/2012)
In clear violation of the Supreme Court order of 2004 saying that only self-help groups, mahila mandals and village communities be given contracts for the supply of nutrition, the state government is all set to hand over the supply tender to a private company — Great Value Food run by liquor baron Gurdeep Singh Chadha alias Ponty Chadha.
Child development and nutrition department sources said the technical bid for the supply has been finalised in favour of Chadha’s firm and the bid would be finalised by November 9.
Not to be left behind, some firms supplying nutritious food in other states have challenged the tender in the Lucknow bench of the Allahabad high court. Gupta’s counsel Mohammad Altaf Mansoor said the matter would be taken up for hearing in high court on November 19. Sources alleged that Chadha’s firm had the tender tailored by bureaucrats and politicians in such a manner that all competitors were disqualified.
Chadha’s firm had bagged the tender in 2009 too.
Centre’s Supplementary Nutrition Food Programme malnourished children Supreme Court ponty chadha

value: This website is an Indian English-language daily newspaper introduced and founded in 1924 by Sunder Singh Lyallpuri, founder-father of the Akali movement and the Shiromani Akali Dal in the Punjab Province. It played integral roles in the Indian independence movement as a nationalist daily.


text:
Patent US20040138237 - Novel injectable depot formulations - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign in<nobr>Advanced Patent Search</nobr>PatentsAn injectable depot formulation that is viscous, or becomes viscous in situ, comprising a solubilized aryl-heterocyclic pharmaceutical compound, such as ziprasidone, is provided....http://www.google.com/patents/US20040138237?utm_source=gb-gplus-sharePatent US20040138237 - Novel injectable depot formulationsAdvanced Patent SearchPublication numberUS20040138237 A1Publication typeApplicationApplication numberUS 10/690,078Publication dateJul 15, 2004Filing dateOct 21, 2003Priority dateOct 25, 2002Also published asCA2503076A1, CN1849110A, EP1575616A2, WO2004037289A2, WO2004037289A3Publication number10690078, 690078, US 2004/0138237 A1, US 2004/138237 A1, US 20040138237 A1, US 20040138237A1, US 2004138237 A1, US 2004138237A1, US-A1-20040138237, US-A1-2004138237, US2004/0138237A1, US2004/138237A1, US20040138237 A1, US20040138237A1, US2004138237 A1, US2004138237A1InventorsJaymin ShahOriginal AssigneePfizer IncExport CitationBiBTeX, EndNote, RefManReferenced by (2), Classifications (14), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetNovel injectable depot formulationsUS 20040138237 A1Abstract An injectable depot formulation that is viscous, or becomes viscous in situ, comprising a solubilized aryl-heterocyclic pharmaceutical compound, such as ziprasidone, is provided. Images(7) Claims(18)
FIELD OF INVENTION [0002] The invention pertains to injectable depot formulations for aryl-heterocyclic compounds, such as arylpiperazinyl-C2 and -C4 alkyleneheterocycle compounds, including ziprasidone; and methods for making same. The injectable depot formulations of the invention permit controlled release of the active aryl-heterocyclic substances over prolonged periods of time after administration to a patient via intramuscular (IM) injection, for example. BACKGROUND OF THE INVENTION [0003] Certain aryl-heterocyclic compounds are known to have psychotropic effects. Ziprasidone in particular is a chlorooxyindole class aryl-heterocyclic that is an atypical anti-psychotic agent often prescribed for the treatment of schizophrenia. Atypical anti-psychotics such as ziprasidone offer distinct advantages over traditional anti-psychotic medications insofar as they are associated with lower incidences of side effects, such as extrapyramidal symptoms (EPS), and confer greater efficacy of treatment to patients who are otherwise not responsive to more traditional drug therapies. Certain illnesses, such as schizophrenia, can be particularly difficult to medicate inasmuch as they are considered to be heterogeneous diseases whereby not all patients react similarly to the same treatment regimen. Exacerbating this is the problem that commonly attends long term treatment of schizophrenia; namely, non-compliance by patients with their dosage schedules. Indeed, it is conventionally thought that substantial numbers of schizophrenic patients are not or only partially compliant with their medication. Poor compliance can cause relapse into the psychotic condition thereby negating whatever benefits were achieved through treatment in the first place. [0004] Where patient compliance is an issue, resort is sometimes had to long acting dosage forms of the medication. That is, dosage forms where a single administration leads to a sustained release of the medication over an extended period of time. This, in turn, simplifies the dosage regimen that a patient need adhere to, thus reducing the opportunity for non-compliance as occurs with a more rigorous schedule. Among such dosage forms is the depot formulation, which can be administered in various ways including intramuscularly by injection. The depot dosage injection is specifically formulated to provide slow absorption of the drug from the site of administration, often keeping therapeutic levels of same in the patients system for days or weeks at a time. But there are instances where the use of a depot form has not been available. For example, in current practice, ziprasidone is administered once or twice daily in the form of an immediate release (IR) capsule for acute and long term treatment of schizophrenia; or is administered in intramuscular immediate release injection form for acute control of agitation in schizophrenic patients. Ziprasidone is poorly soluble. Indeed, for the intramuscular immediate release formulation aforesaid, even ziprasidone mesylate, which is generally soluble relative to other known ziprasidone salts, has to be solubilized further, presently with the use of cyclodextrins as described in U.S. Pat. No. 6,232,304 incorporated herein by reference, to render it efficacious. [0005] In the case of ziprasidone, it has been found that its poor solubility, which suggests amenability to a depot formulation where the drug should not be too soluble (to avoid burst) and release must be prolonged, does not in fact provide adequate pharmacokinetic exposure when constituted as such in a depot formulation. [0006] Consequently, there is a need for a depot formulation for aryl-heterocyclic compounds, such as ziprasidone, which can provide drug delivery over a sustained period of time at concentrations efficacious for treatment of, e.g. schizophrenia, in mammals including humans. SUMMARY OF THE INVENTION [0007] The invention is premised on the finding that the solubilized forms of aryl-heterocyclics typically associated with (or with solubilized levels of active ingredient even greater than) immediate release, can be surprisingly fabricated into depot formulations. Hence in one aspect, the present invention is directed to an injectable depot formulation comprising a solubilized aryl-heterocyclic compound, such as ziprasidone, and a viscosity agent. DETAILED DESCRIPTION OF THE INVENTION [0008] The injectable depot formulation of the invention provides significantly higher solubility of the aryl-heterocyclic drug in the formulation. The invention achieves this improved drug loading and delivery by using solubilizers cooperatively with viscosity agents to obtain the controlled release typifying a depot effect. [0009] The invention is useful in treating psychotic illnesses such as schizophrenia in mammals, including humans in need of such treatment. The invention is also useful in treating other disorders and conditions, the treatment of which is facilitated by ziprasidone administration. Thus the present invention has application where ziprasidone use is indicated as e.g. in U.S. Pat. Nos. 6,245,766; 6,245,765; 6,387,904; 5,312,925; 4,831,031; and European EP 0901789 published Mar. 17, 1999, all of which are incorporated herein by reference. [0010] The drug compounds contemplated for use in the present invention are aryl-heterocyclics, preferably those that have pharmacologic activity, e.g. psychotropic effects. Without limitation, an embodiment of an aryl-heterocyclic compound subject to the practice of the present invention has the structure: [0011] wherein [0012] Ar is benzoisothiazolyl or an oxide or dioxide thereof, each optionally substituted by one fluoro, chloro, trifluoromethyl, methoxy, cyano, or nitro: n is 1 or 2; and [0013] X and Y together with the phenyl to which they are attached form benzothiazolyl; 2-aminobenzothiazolyl; benzoisothiazolyl; indazolyl; 3-hydroxyindazolyl; indolyl; oxindolyl optionally substituted by one to three of (C1-C3)alkyl, or one of chloro, fluoro or phenyl, said phenyl optionally substituted by one chloro or fluoro; benzoxazolyl; 2-aminobenzoxazolyl; benzoxazolonyl; 2-aminobenxozazolinyl; benzothiazolonyl; benzoimidazolonyl; or benzotriazolyl. Representative examples of compounds falling within the foregoing definition are found in U.S. Pat. No. 4,831,031 incorporated herein by reference. [0014] In one practice, the invention preferably applies to the above compounds wherein X and Y together with the phenyl to which they are attached form oxindole; more preferably, the oxindole moiety is 6-chlorooxindole-5-yl. In another preferred practice, Ar is benzoisothiazoyl; in still another preferred practice, n is 1. A particularly preferred aryl-heterocyclic to which the invention pertains is ziprasidone, which has the structure: [0015] Although the aryl heterocyclic compound described herein may be constituted as a free base, it is preferred if aryl-heterocyclic compound is present as a pharmaceutically acceptable salt. The term �salt� in this regard intends pharmaceutically acceptable acid addition salts of aryl-heterocyclics, including ziprasidone. For purposes of preparing the formulation of the invention, the salts can be anhydrous or in the form of one or more solvates, such as hydrates, including mixtures thereof. The salts may also occur in different polymorphic forms. By way of exemplification only, mesylate salts of the aryl heterocyclic ziprasidone may be present in dihydrate or trihydrate forms as disclosed in U.S. Pat. Nos. 6,110,918 and 6,245,765 both of which are incorporated herein by reference. Without limitation, preferred salts are selected from the group consisting of the tosylate, tartrate, napsylate, besylate, aspartate, esylate and mesylate salt. In an especially preferred practice, the aryl heterocyclic is ziprasidone mesylate, more preferably in the trihydrate form. [0016] The term �ziprasidone�, as used herein, unless otherwise indicated, includes ziprasidone free base and all pharmaceutically acceptable salts of ziprasidone, including all polymorphic forms thereof. [0017] The injectable depot formulation of the present invention provides delivery of the aryl heterocyclic active agent at concentrations effective for treatment of illnesses such as schizophrenia over a sustained period of time, i.e. for a period of time beyond that which is obtained by immediate release injection systems. Thus by way of further definition the injectable depot formulation of the present invention provides for example efficacious plasma levels of active agent for at least about 8 hours using typical injection volumes, e.g. about 0.1 ml to about 3 ml, about 1 ml to about 2 ml being usual. Preferably, the sustained period provided by the invention is at least about 24 hours; more preferably up to about 1 week; still more preferably from about 1 week to about 2 weeks or more including up to about 8 weeks using the injection volumes aforesaid. [0018] For example, in the case of ziprasidone, the practice of the invention can deliver at least 0.5 to about 350 mgA per ml injection. Typically, the injection volume is from about 1 ml to about 2 ml, thereby providing delivery of from about 0.5 mgA to about 700 mgA ziprasidone over a sustained period of time. More preferably, about 10 mgA to about 560 mgA ziprasidone is provided per injection over a sustained period of time, even more preferably about 280 mgA to about 560 mgA. As above described, an injection of the subject depot formulation can result in a sustained delivery of such amounts of ziprasidone over a period of time. In one embodiment, the period of time is at least about 8 hours, more preferably at least about 24 hours, even more preferably at least about 1 week. In another embodiment, the injection provides a sustained delivery of such amounts of ziprasidone for a period of time of at least about 2 weeks. In a further embodiment, the injection provides a sustained delivery of such amounts of ziprasidone for a period of time of up to about 8 weeks. [0019] In the practice of the invention the aryl heterocyclic compound is solubilized. The term �solubilized� and related variations of same as used herein means that the heterocyclic has a solubility in water that is in excess of its free or salt forms to a degree sufficient to provide the prolonged (depot) duration of systemic exposure of active agent at the therapeutic levels contemplated by the invention. Without limitation, the heterocyclic can be �solubilized� using a cyclodextrin or other solubilizer to achieve the increased solubility contemplated herein. Thus the heterocyclic may be partly or fully solubilized. For convenience, the invention will now be further described exemplifying ziprasidone as the aryl heterocyclic compound. It is to be understood that the following discussion does not limit the scope of the invention and that the techniques hereinafter described appertain to and can be adapted for the family of aryl heterocyclics as disclosed herein. Other techniques that achieve the purposes stated can also be implemented and are envisioned as within the inventive practice. [0020] The term �mgA/ml� as used herein relates to the weight (in mg) of aryl-heterocyclic compound, e.g. ziprasidone, per ml of composition to which the term is being applied. For ziprasidone free base, molecular weight=412.9. [0021] In one embodiment, ziprasidone concentration is at least about 0.5 to about 350 mgA/ml, for example about 60mgA/ml, in the depot formulation of the present invention which can include amounts in solution and amounts in suspension as appertain. More preferably for ziprasidone, concentration is between about 70 mgA/ml to about 280 mgA/ml depot formulation, including between about 140 mgA/ml and about 210 mgA/ml, of depot formulation; higher concentrations are also within the scope of the invention. Various techniques to solubilize ziprasidone to obtain these levels of concentration involve, without limitation, the use of cyclodextrins and other solubilizers. [0022] The preferred solubilizer (to form the solubilized aryl-heterocyclic compound of the invention) is a cyclodextrin. Cyclodextrins are cyclic oligosaccharides with hydroxyl groups on the outer surface and a void cavity in the center. The outer surface is usually hydrophilic hence cyclodextrins are soluble in water. The void on the other hand is typically hydrophobic. Cyclodextrins have the ability to form complexes with guest molecules, such as ziprasidone. Cyclodextrins contemplated by the invention include without limitation: α, β,γ-cyclodextrins, methylated cyclodextrins, hydroxypropyl-β-cyclodextrin (HPBCD), hydroxyethyl-β-cyclodextrin (HEBCD), branched cyclodextrins in which one or two glucoses or maltoses are enzymatically attached to the cyclodextrin ring, ethyl- and ethyl-carboxymethyl cyclodextrins, dihydropropyl cyclodextrins, and sulfoalkyl ether cylcodextrins, such as sulfobutyl ether-β-cyclodextrin (SBECD). The cyclodextrins can be unsubstituted or substituted in whole or in part as known in the art; mixtures of cyclodextrins are also useable. The preferred cyclodextrins for the depot formulation of the invention include γ-cyclodextrin, HPBCD, SBECD or mixtures thereof; SBECD being most preferred. [0023] Cyclodextrin complexes with ziprasidone can be rendered soluble in water as described in U.S. Pat. No. 6,232,304 incorporated by reference above. For purposes of the invention, a pre-formed (solid) complex of cyclodextrin and ziprasidone can be employed, or the cyclodextrin can be presented separately into the depot formulation to solubilize the ziprasidone, such as by adding the cyclodextrin conjointly or in admixture with the viscosity agent or other components. [0024] Viscosity agents include those known in the art such as viscosified water, pharmaceutically acceptable oils and oil-based agents, polymeric agents and other non-aqueous viscous vehicles. Preferred viscosity agents include without limitation: cellulose derivatives, polyvinylpyrrolidone, alginates, chitosan, dextrans, gelatin, polyethylene glycols, polyoxyethylene ethers, polyoxypropylene ethers, polylactides, polyglycolides, polycaprolactones, polyanhydrides, polyamines, polyurethanes, polyesteramides, polyorthoesters, polydioxanones, polyacetals, polycarbonates, polyorthocarbonates, polyphosphazenes, succinates, polycarbonates, poly(maleic acid), poly(amino acids), polyhydroxycellulose, chitin, copolymers and terpolymers of the foregoing, and mixtures thereof. Preferred cellulose derivatives include methyl cellulose, sodium carboxymethyl cellulose (NaCMC) and hydroxypropyl methyl cellulose. Preferred polylactides, polyglycolides, copolymers and terploymers thereof include poly-lactic-co-glycolic acid (PLGA). Also contemplated as viscosity agents for the present invention are in situ gelling systems, e.g. stearic acid (SA) and N-methyl pyrrolidone (NMP) combinations, sucrose acetate isobutyrate, PLGA. [0025] In the practice of the invention, the viscosity agent is present in an amount effective to provide the depot effect contemplated herein. Among other considerations in this regard, an effective amount of viscosity agent is that amount necessary to provide the depot formulation of the invention with a viscosity of greater than about 3.2 centipoise (cps); more preferably between about 20 and about 200 cps; still more preferably between about 30 and about 165 cps. [0026] In a first embodiment of the invention, ziprasidone is solubilized with a cyclodextrin such as SBECD, wherein the cyclodextrin is present in a concentration of up to about 60% w/v, more preferably, a concentration of about 40% w/v, still more preferably a concentration of about 30%. In another embodiment, the depot formulation comprises a concentration of cyclodextrin, e.g. SBECD, of from about 5% to about 35%, especially from about 10% to about 20%. In a preferred aspect, the depot formulation comprising a cyclodextrin in this regard takes the form of an aqueous suspension, wherein the viscosity agent, e.g. NaCMC or the like, is present in water, e.g. sterilized water for injection, in an amount sufficient to render the viscosity of the depot formulation greater than 3.2 cps, preferably between about 20 cps to about 200 cps, more preferably, between about 30 cps to about 165 cps. For example, NaCMC can be present in an amount of about 0.1% w/v to about 3% w/v, preferably from about 0.5% w/v to about 2%. Optionally, the aqueous suspension depot formulation further comprises a pharmaceutically acceptable surfactant, for example a polyoxyethylene sorbitan ester such as Polysorbate 80 (Tween 80). The pharmaceutically acceptable surfactant can be present in an amount e.g. of up to about 1% w/v; preferably about 0.01 to about 0.1%. [0027] In one practice of this first embodiment, the depot formulation can be in kit form as described in commonly-owned U.S. Provisional Application 60/421,295 filed Oct. 25, 2002, and as described in patent applications claiming priority of U.S. 60/421,295, the entire contents of which are incorporated herein by reference. By way of example only, the kit includes a first component of e.g. dry ziprasidone mesylate trihydrate in an amount sufficient to provide a dosage within the ranges described above, i.e. from about 0.5 mgA to about 350 mgA per ml depot formulation; and separately a second component comprised of viscous aqueous vehicle, such as NaCMC and a sufficient amount of water to render a total volume for injection of about 1 to about 3 ml, preferably 1 to about 2 ml; and SBECD or another cyclodextrin in an amount of about 5 to about 35% w/v to solubilize the ziprasidone. Optionally, a pharmaceutically acceptable surfactant, such as, without limitation, a polyoxyethylene sorbitan ester such as Polysorbate 80 (Tween 80) can be included with the viscosified NaCMC-water to improve wetting of the dry ziprasidone when the contents of the two elements are admixed together to form the injectable depot formulation of the invention. A depot formulation formulated as such can, in one embodiment, deliver at least about 10 to about 30 mg per day of ziprasidone for at least about 8 hours, preferably at least about 24 hours, more preferably at least about 1 week, even more preferably at least about 2 weeks. [0028] In a second embodiment of the invention, a high concentration of cyclodextrin, e.g. SBECD, is utilized. In this embodiment, the cyclodextrin serves as both solubilizer and viscosity agent. That is, at high concentrations of cyclodextrin, the complex with ziprasidone forms an aqueous solution having a viscosity sufficiently high to provide a depot formulation. Ziprasidone in this regard is solubilized with a cyclodextrin concentration of greater than about 50% w/v, preferably from about 50% w/v to about 60% w/v; more preferably, the cyclodexdrin concentration is between about 55% to about 60% w/v, e.g. about 56% to about 57% w/v. Thus in one practice of this embodiment, about 80 mgA/ml of ziprasidone is solubilized with about 56% SBECD to create an aqueous solution suitable for an injectable depot formulation with a viscosity of about 22.6 cps and higher. In an optional practice, a crystallization inhibitor such as polyvinyl pyrrolidone (e.g. PVP 30) and the like may be added to delay crystallization and enhance the physical stability of the depot formulation. [0029] In a third embodiment of the invention, a complex of ziprasidone and a cyclodextrin is formed and isolated as a solid. This solubilized solid complex can then be suspended in a suitable viscosity vehicle, including non-aqueous viscous agents in which the ziprasidone-cyclodextrin complex is not soluble. Without limitation, a solid preformed complex can be obtained by lyophilizing the high concentration solution of the second embodiment described above. The lyophilized complex can be suspended in non-aqueous viscosity agents including without limitation: sesame seed oil, including aluminum monostearate (ALMS) gelled sesame seed oil; and in situ gelling systems such as e.g. stearic acid (SA) and NMP combinations. [0030] In a fourth embodiment of the invention, ziprasidone is solubilized using a combination of cyclodextrin and one or more co-solvents in which said ziprasidone is soluble. Without limitation, a mixture of cyclodextrin such as SBECD and a co-solvent or co-solvents, such as a pyrrolidone or mixture of pyrrolidones, for example 2-pyrrolidone and/or NMP, in water, can be used to form the solubilized ziprasidone of the invention. Suitable viscosity agents, such as polyethylene glycol (PEG), can be employed to form the injectable depot formulation of the invention. For example, solutions of up to about 140 mgA/ml ziprasidone mesylate salt can be prepared using 60% NMP/water with 40% SBECD with 10% PEG (e.g. PEG 3350); in another practice of this embodiment, a 140 mgA/ml solution of ziprasidone can be prepared using 60% 2-pyrrolidone/water with 40% SBECD and 30% PEG 3350 as viscosity agent. In an optional practice, a crystallization inhibitor, such as PVP 30, at e.g. up to about 70 mg/ml, can be added. In another aspect of this embodiment of the invention, a non-aqueous depot formulation can be prepared in accordance with the invention by utilizing the co-solvents above with non-aqueous but polar solvents such as benzyl benzoate (BB) and the like. For example, a 140 mgA/ml ziprasidone formulation can be prepared using 30% BB, 70% 2-pyrrolidone with 40% SBECD, the formulation having a viscous gel-like consistency suitable for a depot effect. [0031] Additionally, pH modifiers known in the art to be acidic in nature may be employed in any of the foregoing formulations. [0032] The following examples are illustrative only; they are not to be construed as limiting of the scope or spirit of the invention.
EXAMPLE 1 [0033] This example demonstrates an embodiment of the invention wherein the depot formulation comprises ziprasidone solubilized with cyclodextrin and having a cellulose derivative as a viscosity agent forming an aqueous suspension. [0034] 175 mgA of ziprasidone powder in the form of ziprasidone mesylate trihydrate was provided. The ziprasidone powder was admixed with a vehicle constituted as follows: [0035] SBECD at 30% w/v [0036] Sodium carboxymethyl cellulose (NaCMC) at 0.5% w/v [0037] Polysorbate 80 (Tween 80) at 0.02% w/v [0038] Sterile water for injection q.s. at 2.5 ml. [0039] Total fill of the vehicle was 3 ml. The ziprasidone powder was admixed with 2.3 ml of the vehicle to produce a 2.5 ml aqueous suspension at 70 mgA/ml ziprasidone. The resultant admixture was agitated for 1 minute followed by a 15 minute period of waiting to wet the ziprasidone powder whereafter the admixture was again agitated for an additional minute. A 21 gauge syringe was loaded with 2 ml of the final admixture to provide a dose of 140 mg ziprasidone. Viscosity was about 31 to about 80 cps. [0040] The pharmacokinetic (PK) profile of the foregoing aqueous suspension depot formulation obtained from the kit of the invention was investigated in beagle dogs and compared to the following: Comparative Sample (1): an immediate release formulation comprised of solubilized ziprasidone, but no viscosity agent; and Comparative Sample (2): an aqueous suspension comprised of a viscosity agent (SBECD) and unsolubilized ziprasidone. The 2 ml volumes in all cases were injected intramuscularly and plasma levels measured over time. The results were as follows: Comparative Sample (1) showed no depot effect, i.e. the serum concentration of ziprasidone was not quantifiable after 48 hrs; there was no sustained serum concentration. Comparative Sample (2) showed a ziprasidone serum concentration of 4.6�2.4 ng/ml (mean of 12-336 hrs). The present invention on the other hand showed a ziprasidone serum concentration of 12.9�3.7 ng/ml, which represented an increase in depot effect of approximately 280% over that of the next closest sample, Comparative Sample (2). [0041] Four other ziprasidone aqueous suspension depot formulations, two each providing 140 mgA/ml and 210 mgA/ml, but with different concentrations of cyclodextrin, were prepared as set forth in the following Table 1: TABLE 1 Various combinations of the two vials and dosing instructions to prepare 140 and 210 mgA/ml aqueous suspensions with vehicle containing 10 and 20% SBECD. Formulation No. Vial 1: Drug Powder Vehicle Dosing Instruction 1 Ziprasidone mesylate 1.5% NaCMC 7LF, Constitute and dose 140 mgA/ml in 735 mgA/vial 10% SBECD, 0.1% within 15 to 45 vehicle with 10% Tween 80 minutes SBECD 4.6 ml 2 Ziprasidone mesylate 0.5% NaCMC 7H3SF, Constitute and dose 140 mgA/ml in 735 mgA/vial 20% SBECD, 0.1% within 15 to 45 vehicle with 20% Tween 80 minutes SBECD 4.6 ml 3 Ziprasidone mesylate 1.5% NaCMC 7LF, Constitute and dose 210 mgA/ml in 735 mgA/vial 10% SBECD, 0.1% within 15 to 45 vehicle with 10% Tween 80 minutes SBECD 2.9 ml 4 Ziprasidone mesylate 0.5% NaCMC 7H3SF, Constitute and dose 210 mgA/ml in 735 mgA/vial 20% SBECD, 0.1% within 15 to 45 vehicle with 20% Tween 80 minutes SBECD 2.9 ml EXAMPLE 2 [0042] This example demonstrates an embodiment of the invention wherein the depot formulation is a non-aqueous suspension comprising a pre-formed ziprasidone/cyclodextrin complex and having a viscosity agent. [0043] An isolated pre-formed complex of ziprasidone mesylate trihyrate and SBECD was prepared as follows: [0044] A 1095.3 gm batch of solution was prepared in an 80� C. water bath. After SBECD was dissolved in sterilized water for injection (SWFI) ziprasidone mesylate trihydrate was added to the resulting solution. During the entire process, the solution was stirred magnetically. The drug solution (82 mgA/ml) was filtered through a 0.45 μm filter and 2 ml aliquots were pipetted into 20 ml vials. [0045] The vials of solution prepared above were lyophilized to obtain the ziprasidone-SBECD complex as a freeze dried solid. A lyophilization cycle was used with the following conditions: 1) Freezing step: temperature was −55� C. at 1� C./minute; 2) Primary drying: from −55� C. to −32� C. at 0.05� C./minute, held at −32� C. for 7 days, vacuum 100 mTorr; 3) Secondary drying: from −32� C. to 8� C. at 0.1� C./minute, held at 8� C. for 20 hours, vacuum 70 mTorr, then from 8� C. to 30� C. at 0.1� C./minute, held at 30� C/ for 20 hours, vacuum 70 mTorr. The complex was comprised of ziprasidone at approximately 80 mgA/ml with about 56% SBECD. [0046] Samples of the lyophilized complex were suspended in the various biocompatible, sustained release non-aqueous vehicles. The mean serum concentration of ziprasidone over a 12-336 hour period achieved in beagle dogs who had received non-aqueous depot suspensions are shown below in Table 2. TABLE 2 Formulation Mean Serum No. Depot Formulation Concentration (ng/ml) 1 Suspension in 2% Aluminum Depot = 18 ng/ml Monostearate (ALMS) gelled Sesame oil (60 mgA/ml; 2 ml injection) 2 Suspension in 100-300 mg Depot = 18.76 ng/ml Stearic acid (SA) in NMP (70 mgA/ml; 2 ml injection) EXAMPLE 3 [0047] This example demonstrates an embodiment of the invention wherein the depot formulation comprises ziprasidone solubilized with cyclodextrin where the cyclodextrin also serves as the viscosity agent. This particular example employs a high concentration of SBECD to form an aqueous solution of ziprasidone at about 80 mgA/ml with about 56% SBECD. To facilitate drug dissolution, a pre-weighed amount of SBECD (gram weight SBECD equivalent to ml of depot formulation being prepared) was dissolved in water by heating in a water bath at 50� C. Ziprasidone mesylate was added in about 50 mg increments while heat was supplied to maintain the system at 50-60� C. A total of 572.99 mg Ziprasidone mesylate was added to 3 ml of 100% SBECD solution resulting in formation of 140 mgA/ml (191 mg/ml) clear viscous solution. The above solution was cooled to room temperature, and the solution remained clear for 2 weeks. Due to volume expansion, the final concentration of ziprasidone was about 80 mgA/ml with 56% cyclodextrin. [0048] Preparation of the above formulation was scaled up as follows to prepare a stock solution and to analyze the volume expansion and measure ziprasidone concentration using HPLC: [0049] The stock solution was prepared using the same method as described above, however due to the higher solution volume (20 ml), the dissolution time was much longer (over 4 hours) even though micronized ziprasidone mesylate was used. During compounding, significant volume expansion was noted. To correct for the volume expansion, the specific gravity of the solution was determined to be 1.188 gm/ml. The volume of water used to prepare this solution was 20 ml, however, the final volume of the solution was 36.6 ml, and the weight of the solution was 43.5 gm. Therefore, taking into consideration 83% volume expansion, the corrected concentrations of drug and SBECD in this solution are 77 mgA/ml and 55% w/v, respectively. HPLC analysis of this solution by the potency method showed a potency of 75 mgA/ml (102.3 mg/ml), and no degradation products were detected. [0050] The above two preparations resulted in ziprasidone solution at 77 mgA/ml with 55% SBECD indicating significantly higher solubility of ziprasidone with relative lower molar ratio of SBECD to drug (1.3:1), more than would be predicted based on a linear phase solubility diagram of ziprasidone and SBECD. The extent of solubilization was further confirmed by preparation of 82 mgA/ml ziprasidone solution with 59% SBECD using the same method. Viscosity was greater than 160 cps. Referenced byCiting PatentFiling datePublication dateApplicantTitleUS20110144202 *Jun 9, 2009Jun 16, 2011Uwe MarxConcentrated oxaliplatin solution and its method of preparationWO2007027273A1 *Jun 19, 2006Mar 8, 2007John DevaneNanoparticulate and controlled release compositions comprising aryl-heterocyclic compounds* Cited by examinerClassifications U.S. Classification514/259.41, 424/486International ClassificationA61K31/496, A61K47/00, A61K9/14, A61K31/519, A61K47/40, A61K9/00Cooperative ClassificationA61K47/40, A61K31/496, A61K9/0019European ClassificationA61K31/496, A61K9/00M5, A61K47/40Legal EventsDateCodeEventDescriptionApr 1, 2005ASAssignmentOwner name: PFIZER INC., NEW YORKFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SHAH, JAYMIN CHANDRAKANT;REEL/FRAME:015994/0462Effective date: 20041216RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google

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S Theodoropoulos - Semantic Scholar
S Theodoropoulos
M H Yacoub13
M Yacoub7
C J Mathias6
N Dhalla6
9Magdi Yacoub
9N R Banner
8Asghar Khaghani
7Nazir Dhalla
Location, localization and surgical treatment of cardiac pheochromocytoma.
D. Aravot, Nicholas Robert Banner, Alan M Cantor, S Theodoropoulos, Magdi Habib Yacoub
Mohamed Zine-El-Abidine Amrani, Nicola J Allen, +6 authors Magdi Habib Yacoub
The aim of this study was to investigate the roles of heat shock proteins and catalase after heat shock stress in the recovery of cardiac mechanical and endothelial function following a prolonged… (More)
Increased sensitivity of the denervated transplanted human heart to isoprenaline both before and after beta-adrenergic blockade.
S M Yusuf, S Theodoropoulos, +4 authors Magdi Yacoub
It is not known whether surgical denervation leads to increased beta-receptor sensitivity after human cardiac transplantation. We assessed cardiac beta-receptor sensitivity by studying the heart rate… (More)
Effect of betablockade on dynamic exercise in human heart transplant recipients.
S M Yusuf, S Theodoropoulos, N Dhalla, Christopher J. Mathias, Magdi Yacoub
We evaluated the tolerance of heart transplant recipients to acute betablockade during maximal dynamic exercise. Although the increase in rate and systolic blood pressure were attenuated, exercise… (More)
Asghar Khaghani, Nicholas Robert Banner, +5 authors Magdi Habib Yacoub
Between December 1983 and April 1989, 222 combined heart and lung transplant operations were performed for treatment of pulmonary vascular disease and parenchymal lung disease at Harefield Hospital.… (More)
Renin response to sympathetic stimulation in cyclosporin-treated heart-transplant patients.
Peter Held, S M Yusuf, Christopher J. Mathias, N Dhalla, S Theodoropoulos, Magdi Yacoub
Magnetic resonance characterization of pulmonary arterial blood flow after single lung transplantation.
Raad H. Mohiaddin, Robert Paz, S Theodoropoulos, David N. Firmin, Donald B. Longmore, Magdi Habib Yacoub
Magnetic resonance imaging has been used to study pulmonary arterial anatomy and to measure pulmonary arterial blood flow in patients with single lung transplantation. Nine patients and nine control… (More)
Asghar Khaghani, Samad Tadjkarimi, +5 authors Magdi Habib Yacoub
Between May 1989 and March 1990, 36 patients undergoing a first single lung transplantation were randomized to three groups. In the omentum group the bronchial anastomosis was wrapped with an omental… (More)
M Albertucci, K Wong, +4 authors Magdi Habib Yacoub
Unstented homograft valves offer several theoretical advantages when used for patients who have had previous operations on the aortic valve. Between January 1970 and February 1993, 177 patients… (More)
Jaroslav Špatenka, Asghar Khaghani, Jacquelyn Irving, S Theodoropoulos, Zdeněk Slavík, Magdi Habib Yacoub
Three patients with recurrent bronchial stenosis following single lung transplant (SLTx), and one patient with tracheal stenosis following heart-lung transplantation (HLTx), not responding to… (More)

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overview for EcSamjump to contentmy subredditsannouncementsArtAskRedditaskscienceawwblogbookscreepydataisbeautifulDIYDocumentariesEarthPornexplainlikeimfiveFitnessfoodfunnyFuturologygadgetsgamingGetMotivatedgifshistoryIAmAInternetIsBeautifulJokesLifeProTipslistentothismildlyinterestingmoviesMusicnewsnosleepnottheonionOldSchoolCoolpersonalfinancephilosophyphotoshopbattlespicsscienceShowerthoughtsspacesportstelevisiontifutodayilearnedTwoXChromosomesUpliftingNewsvideosworldnewsWritingPromptsedit subscriptionsfront-all-random | Fitness-food-history-funny-creepy-LifeProTips-news-personalfinance-UpliftingNews-philosophy-photoshopbattles-videos-sports-gaming-askscience-DIY-nosleep-movies-aww-listentothis-Art-AskReddit-WritingPrompts-tifu-IAmA-space-Futurology-worldnews-EarthPorn-InternetIsBeautiful-Documentaries-Music-nottheonion-mildlyinteresting-dataisbeautiful-gifs-gadgets-books-science-OldSchoolCool-todayilearned-pics-TwoXChromosomes-Showerthoughts-explainlikeimfive-television-GetMotivated-Jokesmore »reddit.com EcSamoverviewcommentssubmittedgildedwant to join? login or register in seconds|EnglishEcSam1 link karma1 comment karma send messageredditor for 1 yearwhat's this?TROPHY CASEOne-Year Clubremember mereset passwordlogindaily reddit gold goal25%help support redditreddit gold gives you extra features and helps keep our servers running. We believe the more reddit can be user-supported, the freer we will be to make reddit the best it can be.Buy gold for yourself to gain access to extra features and special benefits. A month of gold pays for 231.26 minutes of reddit server time!Give gold to thank exemplary people and encourage them to post more.This daily goal updates every 10 minutes and is reset at midnight Pacific Time (20 hours, 17 minutes from now).Yesterday's reddit gold goal97%reddit's stories are created by its usersjoin the community, vote, and change the world.learn more ›sorted by: newhotnewtopcontroversial234[5th] So Close! (self.pokemontrades)submitted 1 year ago by EcSam to /r/pokemontrades4 commentssharecancelsorry, this has been archived and can no longer be voted onloading...[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI'm here in Wifi room.
permalinkcontextfull comments (27)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onSure! Much appreciation on helping me with my pokedex
permalinkcontextfull comments (27)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onGMT-6 (Chicago Central). I'll be available after 2PM in that time Zone.
permalinkcontextfull comments (27)(5th) Giveaway!!! 5 Beldums 5 Feebas 5 Scythers 5 Ralts 5 Gastlys 2 Lapras and 2 Lickitun by adrianx1313in Pokemongiveaway[–]EcSam 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI'm in the Wifi room! Thank you!
permalinkcontextfull comments (171)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 1 point2 points3 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI appreciate the offer. I'll be around tomorrow evening and might take you up then if you're still willing :)
permalinkcontextfull comments (27)(5th) Giveaway!!! 5 Beldums 5 Feebas 5 Scythers 5 Ralts 5 Gastlys 2 Lapras and 2 Lickitun by adrianx1313in Pokemongiveaway[–]EcSam 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI'll take a gastly, if you don't mind
permalinkcontextfull comments (171)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onyou went to the Wifi room in the middle, didn't you?
permalinkcontextfull comments (27)567[Question] On Dream World... (self.pokemon)submitted 1 year ago by EcSam to /r/pokemon2 commentssharecancelsorry, this has been archived and can no longer be voted onloading...[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted oninternet is being a bit spotty, but I'm in here. Thanks again.
permalinkcontextfull comments (27)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI'd take one, if you don't mind!
permalinkcontextfull comments (27)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI'd take it, if you're offering :)
permalinkcontextfull comments (27)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onSorry Tiki. I'd done goofed. Fixed my FC so now it should actually work.
permalinkcontextfull comments (27)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI had the same issue. it is 4771-8929-6962. I just fixed it in the flair. <.<
permalinkcontextfull comments (27)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onhad the same issue, just try again. Should work.
permalinkcontextfull comments (27)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI'll add you, one sec.
permalinkcontextfull comments (27)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onlook at the flair next to my name and add it to your pal pad, then go to the second floor of a pokecenter, middle person
permalinkcontextfull comments (27)[5th] LF Any starters but 5th Gen and Bulbasaur by EcSamin Pokemongiveaway[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onyeah. Adding you now.
permalinkcontextfull comments (27)234[5th] LF Any starters but 5th Gen and Bulbasaur (self.Pokemongiveaway)submitted 1 year ago * by EcSam to /r/Pokemongiveaway27 commentssharecancelsorry, this has been archived and can no longer be voted onloading...Giveaway! by nanakeyin Pokemongiveaway[–]EcSam 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI'd like A Squirte, Charmander, and Kakuna if you please :)
permalinkcontextfull comments (146)Massive Togepi Giveaway including DW!!! by rh2ridoyin Pokemongiveaway[–]EcSam 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI'll take whatever you have. Not looking for a particular nature, just to fill some pokedex holes.
B2: 4771-8929-6982
permalinkcontextfull comments (131)[5th] LF any Ralts! by ChernobylGypsyin Pokemongiveaway[–]EcSam 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onIf you can trade around 11:20 CT, I'll give you one
permalinkcontextfull comments (2)[5thGen] FT Charmander Giveaway @ 7PM CST by DrButsiein Pokemongiveaway[–]EcSam 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI don't know if I'm too late, but I'd like to get a charmander if you still have any!
permalinkcontextfull comments (30)[5th] LF Bagon/Gen 1 and 2 Favorites by EcSamin pokemontrades[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onThe only pokemon game I have is black 2, so I'm limited to what I can obtain. I've almost completed the Unova Pokedex and I've totally captured I think around 300? Thing is, I'm afraid I don't have anything you all might not have already. Is there a way to link my Pokedex to you via some website like the global link?
permalinkcontextfull comments (10)[5th] LF Bagon/Gen 1 and 2 Favorites by EcSamin pokemontrades[–]EcSam[S] 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI do not. I've been using Pidove//Unfezant as my flying stand-in. Sorry, Wish I could help you out.
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fiction8 comments on Rights Group Fined For Not Paying Artist For Anti-Piracy Adjump to contentmy subredditsannouncementsArtAskRedditaskscienceawwblogbookscreepydataisbeautifulDIYDocumentariesEarthPornexplainlikeimfiveFitnessfoodfunnyFuturologygadgetsgamingGetMotivatedgifshistoryIAmAInternetIsBeautifulJokesLifeProTipslistentothismildlyinterestingmoviesMusicnewsnosleepnottheonionOldSchoolCoolpersonalfinancephilosophyphotoshopbattlespicsscienceShowerthoughtsspacesportstelevisiontifutodayilearnedTwoXChromosomesUpliftingNewsvideosworldnewsWritingPromptsedit subscriptionsfront-all-random | gadgets-sports-gaming-pics-worldnews-videos-AskReddit-aww-Music-funny-news-movies-books-history-food-philosophy-television-Jokes-Art-DIY-space-Documentaries-Fitness-askscience-nottheonion-todayilearned-personalfinance-gifs-listentothis-IAmA-TwoXChromosomes-creepy-nosleep-GetMotivated-WritingPrompts-LifeProTips-EarthPorn-explainlikeimfive-Showerthoughts-Futurology-photoshopbattles-mildlyinteresting-dataisbeautiful-tifu-OldSchoolCool-UpliftingNews-InternetIsBeautiful-sciencemore » technologycommentsrelatedother discussions (7)want to join? sign in or create an account in seconds|Englishlimit my search to /r/technologyuse the following search parameters to narrow your results:subreddit:subredditfind submissions in "subreddit"author:usernamefind submissions by "username"site:example.comfind submissions from "example.com"url:textsearch for "text" in urlselftext:textsearch for "text" in self post contentsself:yes (or self:no)include (or exclude) self postsnsfw:yes (or nsfw:no)include (or exclude) results marked as NSFWe.g. subreddit:aww site:imgur.com dogsee the search faq for details.advanced search: by author, subreddit...this post was submitted on 17 Jul 20122,142 points (95% upvoted)shortlink: remember mereset passwordloginSubmit a new linkSubmit a new text posttechnologysubscribeunsubscribe5,136,406 readers3,522 users here nowBrowse categories:
a community for 7 yearsmessage the moderatorsMODERATORSqgyh2ketralnisAutoModeratorX019creqbillyuprotorcowboypreggithazysummerskyGilgamesh-...and 18 more »214121422143Rights Group Fined For Not Paying Artist For Anti-Piracy Ad (torrentfreak.com)submitted 2 years ago by EquanimousMind159 commentssharecancelsorry, this has been archived and can no longer be voted onloading...sorted by: besttopnewhotcontroversialoldrandomq&ayou are viewing a single comment's thread.view the rest of the comments →[–]fiction8 0 points1 point2 points 2 years ago (0 children)sorry, this has been archived and can no longer be voted onIt's like 10,000 songs...
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text:
Crochet Wash Cloth, Crochet Dish Cloth, Set of 4 Cotton Washcloths
Organic thick cotton embroidered Tote Paradisier
Washable wipes or cotton Washcloths eponge.elephants, princesses, owls and snails.
Vintage 70's Maxi Skirt Plaid Double Knit Nubby Texture Blue Camel Size S
Vintage 1960's Blue Wool Cool with Nubby Texture Large/XL
Vintage 60's Skinny Tie Necktie Unique Brown and Dark Navy Blue Nubby Texture with Stripes Wembley 2"
BODY SCRUBBIES, KITCHEN Scrubby in Brown White and Pink,
Nubby Texture Raw Silk Skirt - Red dirt Girl - 336
Small shoulder bag in thick cotton
Card holder made of thick cotton canvas
Freeform Abstract Valentine Heart Brooch - Nubby Gold Texture
Set of 5 wipes-eco-friendly cotton Washcloths "Grey and blue stars"
Set of 4 organic cotton washcloths
TheBrunetteBee
Set of 3 Crochet Cotton Washcloths, Turquoise/Blue, Navy and Black.
thick cotton bag
Set of 5 wipes-eco-friendly cotton Washcloths "Japanese Red and white"
Short dress or tunic made of thick cotton lace fabric
Set of 3 Crochet Cotton Washcloths, Rose Brown, Purple and Black
Set of 4 thick organic cotton washcloths
Heart Shaped Facial and All-Over Body Scrubbies. Use as a Kitchen Dish Scrubby. Easy to Wash and Care For. Choose Your Favorite Colors.
Black and silver thick 6mm cotton cord
WaterfordSoapinOz
Thick cotton printed folk and liberty
CASE 1A glasses protecteur1 and old, thick cotton

value: This website is an American e-commerce company focused on handmade or vintage items and craft supplies.


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Windermere Staircase Design Ideas, Pictures, Remodel and Decor
"Windermere"
Find out if your remodeling dreams fit your budget reality.Try the Real Cost Finder 32 Windermere Staircase Design Photos
Ideabooks6,312	Questions1	Windermere Lakeside Residencethe way the bolts are fixed on the wood... very clever — Henrique Ireke Embed
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Ideabooks8	Questions0	Upper Windermere Premier - The Modena Show HomeAverton Homes - Upper Windermere Show Home
Contact: 2306 Warry Court SW T: 780-638-5878
...Engineered Ash - Barrique from the HARO line by DIVINE — Divine Flooring Embed
Ideabooks10	Questions0	Upper Windermere Premier - The Modena Show HomeAverton Homes - Upper Windermere Show Home
Ideabooks555	Questions1	Windermere Lakeside Residence...Windermere Lakeside #1no posts — lauriegates77 Embed
SaveEmail	Jackie Syvertsen ~ Windermere Real Estate/BI, Inc.1 Review	Dolphin Drive
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SaveEmail	Luxury Homes in Orlando & Windermere	Pleasure Island Rd, Belle Isle, FL
Ideabooks1	Questions0	Extraordinary home with breath-taking garden & conservatory. This home was on the market for over 3 years, I significantly raised the price and had it under contract within 60 days. Photo by Uneek Luxury Tours.	Embed

value: This website is an American website, online community and software for architecture; interior design and decorating; landscape design and home improvement. It was founded in 2009 and is based in Palo Alto, California.


text:
Patent US7698495 - Computer system having logically ordered cache management - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsA computer system is set forth that includes a processor, general memory storage, and cache memory for temporarily storing selected data requested from the general memory storage. The computer system also may include file system software that is executed by the processor. The file system software may...http://www.google.com/patents/US7698495?utm_source=gb-gplus-sharePatent US7698495 - Computer system having logically ordered cache managementAdvanced Patent SearchPublication numberUS7698495 B2Publication typeGrantApplication numberUS 11/450,140Publication dateApr 13, 2010Filing dateJun 9, 2006Priority dateJul 1, 2005Fee statusPaidAlso published asUS20070005894Publication number11450140, 450140, US 7698495 B2, US 7698495B2, US-B2-7698495, US7698495 B2, US7698495B2InventorsDan DodgeOriginal AssigneeQNZ Software Systems GmbH & Co. KGExport CitationBiBTeX, EndNote, RefManPatent Citations (34), Non-Patent Citations (3), Referenced by (1), Classifications (10), Legal Events (8) External Links: USPTO, USPTO Assignment, EspacenetComputer system having logically ordered cache managementUS 7698495 B2Abstract A computer system is set forth that includes a processor, general memory storage, and cache memory for temporarily storing selected data requested from the general memory storage. The computer system also may include file system software that is executed by the processor. The file system software may be used to manage the file data and the structure of the file system for files stored on the general memory storage. Management of the cache memory is placed under the control of cache management software. The cache management software is executed by the processor to manage the contents of the cache memory pursuant to cache hit and cache miss criterion. Sections of the cache memory are organized by the cache management software based on logical addresses of file data requested from the general memory storage.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4564900 *Feb 10, 1984Jan 14, 1986Christian Rovsing A/SMultiprocessor computer systemUS4926317Apr 12, 1988May 15, 1990Convex Computer CorporationHierarchical memory system with logical cache, physical cache, and address translation unit for generating a sequence of physical addressesUS4945475Nov 21, 1989Jul 31, 1990Apple Computer, Inc.Hierarchical file system to provide cataloging and retrieval of dataUS5187786Apr 5, 1991Feb 16, 1993Sun Microsystems, Inc.Method for apparatus for implementing a class hierarchy of objects in a hierarchical file systemUS5276840 *Mar 22, 1991Jan 4, 1994Acer IncorporatedDisk caching method for writing data from computer memory including a step of writing a plurality of physically adjacent blocks in a single I/O operationUS5455944Mar 16, 1993Oct 3, 1995International Business Machines CorporationMethod for managing logging and locking of page free space information in a transaction processing systemUS5459850 *Feb 19, 1993Oct 17, 1995Conner Peripherals, Inc.Flash solid state drive that emulates a disk drive and stores variable length and fixed lenth data blocksUS5530849Aug 16, 1993Jun 25, 1996Cornell Research Foundation, Inc.Method of reading dynamic, hierarchical file system directoriesUS5539895 *May 12, 1994Jul 23, 1996International Business Machines CorporationHierarchical computer cache systemUS5588129 *Jan 16, 1996Dec 24, 1996Ballard; Clinton L.Cache for optical storage device and method for implementing sameUS5809527 *Dec 23, 1993Sep 15, 1998Unisys CorporationData processing systemUS6058400Apr 28, 1998May 2, 2000Sun Microsystems, Inc.Highly available cluster coherent filesystemUS6292808Dec 3, 1998Sep 18, 2001Oracle CorporationMethod and apparatus for reapplying changes to a databaseUS6571259Sep 26, 2000May 27, 2003Emc CorporationPreallocation of file system cache blocks in a data storage systemUS6591376Mar 2, 2000Jul 8, 2003Hewlett-Packard Development Company, L.P.Method and system for failsafe recovery and upgrade of an embedded operating systemUS6606628Feb 14, 2000Aug 12, 2003Cisco Technology, Inc.File system for nonvolatile memoryUS6748491Apr 19, 2001Jun 8, 2004International Business Machines CorporationDesigning a cache using an LRU-LFU arrayUS6754696Mar 24, 2000Jun 22, 2004Micosoft CorporationExtended file systemUS6845401Dec 30, 1998Jan 18, 2005Schneider Automation Inc.Embedded file system for a programmable logic controllerUS6856993Mar 30, 2000Feb 15, 2005Microsoft CorporationTransactional file systemUS7047257Apr 3, 2001May 16, 2006Qnx Software SystemsComputer file management systemUS7139752May 30, 2003Nov 21, 2006International Business Machines CorporationSystem, method and computer program product for performing unstructured information management and automatic text analysis, and providing multiple document views derived from different document tokenizationsUS7181463Oct 24, 2003Feb 20, 2007Microsoft CorporationSystem and method for managing data using static listsUS7191185Feb 26, 2002Mar 13, 2007Goldman Sachs & Co.Systems and methods for facilitating access to documents via an entitlement ruleUS20020174295Jan 29, 2002Nov 21, 2002Ulrich Thomas R.Enhanced file system failure toleranceUS20050149525Feb 14, 2005Jul 7, 2005Microsoft CorporationTransactional file systemUS20070005560Jul 1, 2005Jan 4, 2007Dan DodgeOptimized startup verification of file system integrityUS20070005614Jul 1, 2005Jan 4, 2007Dan DodgeFile system having deferred verification of data integrityUS20070005615Jul 1, 2005Jan 4, 2007Dan DodgeFile system having inverted hierarchical structureUS20070005627Jun 9, 2006Jan 4, 2007Dan DodgeFile system having transaction record coalescingUS20070005874Jul 1, 2005Jan 4, 2007Dan DodgeFile system storing transaction records in flash-like mediaUS20070113120Jun 28, 2006May 17, 2007Don DodgeSystem employing data verification operations of differing computational costsJPH06139124A Title not availableJPS62186361A Title not available* Cited by examinerNon-Patent CitationsReference1C�rdenas, Alfonso F. "Analysis and Performance of Inverted Data Base Structures." IBM Research Laboratory, San Jose, Communication of ACM May 1975, vol. 18, No. 5, pp. 253-263.2Colyer, A. M. "Displaying and Manipulating Relationships." IBM Technical Disclosure Bulletin, Dec. 1995, vol. 38, Issue No. 12, pp. 391-396.3QNX Software Systems, "Embedded transaction filesystem (ETFS)," System Architecture, 2004, pp. 193-198.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS20140046968 *Apr 6, 2012Feb 13, 2014Tencent Technology (Shenzhen) Company LimitedData acquisition method, device and system* Cited by examinerClassifications U.S. Classification711/3, 710/22, 711/118International ClassificationG06F12/00, G06F13/00, G06F13/28Cooperative ClassificationG06F2212/462, G06F2212/214, G06F12/0866European ClassificationG06F12/08B12Legal EventsDateCodeEventDescriptionApr 4, 2014ASAssignmentFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:8758271 CANADA INC.;REEL/FRAME:032607/0674Effective date: 20140403Owner name: 2236008 ONTARIO INC., ONTARIOOwner name: 8758271 CANADA INC., ONTARIOFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:QNX SOFTWARE SYSTEMS LIMITED;REEL/FRAME:032607/0943Sep 11, 2013FPAYFee paymentYear of fee payment: 4Feb 27, 2012ASAssignmentOwner name: QNX SOFTWARE SYSTEMS LIMITED, CANADAEffective date: 20111215Free format text: CHANGE OF ADDRESS;ASSIGNOR:QNX SOFTWARE SYSTEMS LIMITED;REEL/FRAME:027768/0961Sep 9, 2011ASAssignmentEffective date: 20110613Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:7801769 CANADA INC.;REEL/FRAME:026883/0553Owner name: QNX SOFTWARE SYSTEMS LIMITED, CANADAOwner name: 7801769 CANADA INC., CANADAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:QNX SOFTWARE SYSTEMS GMBH & CO. 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text:
2 bedroom semi-detached bungalow for sale in Tennyson Close, Caistor, Market Rasen, Lincolnshire, LN7
www.rightmove.co.uk/property/63556282
Tennyson Close, Caistor, Market Rasen, Lincolnshire
With storage cupboard and leading to;
Lounge with front aspect window with space for a range of furniture and fitted carpet.
Fitted kitchen with a range of high gloss black wall and base units with workspace above. Integral appliances include oven, hob and extractor hood. Tiled flooring. Space for additional under counter appliances. Tiled flooring. Patio doors leading to the rear garden.
Double sized bedroom with side aspect window. Space for a range of bedroom furniture.
With patio doors leading to the rear garden, tiled flooring and space for a range of furniture. Feature tiled wall.
Suite comprising; panelled bath, WC and pedestal wash hand basin. Modern tiling and flooring.
The property is approached by a paved driveway offering off road parking and a garden laid to lawn.
To the rear of the property is a landscapes garden laid to paving and shingle.
Property ref: 121_1697_4560175
To view this media, please visit the on-line version of this page at www.rightmove.co.uk/property-for-sale/property-63556282.html
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23 Jan 2018 34 Tennyson Close, LN7 £190,000
11 Jul 2017 28 Tennyson Close, LN7 £149,000
19 Dec 2016 14 Tennyson Close, LN7 £132,000

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text: REDMOND, Wash., Jan. 8, 2019 /PRNewswire/ -- Throughout 2018, the Northlake Partners, creators of NorthScope ERP software, invested in expanding NorthScope's features to further support Alaska Seafood Processing. Today, they announced their list of new features that are available with NorthScope. Key features announced for Alaska Seafood Processors include:

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text:
Spin Doctors Two Princes Off my Line 7 inch vinyl single EXCELLENT | eBay Please enable JavaScript Our new search experience requires JavaScript to be enabled. Please enable JavaScript on your browser, then try again.
Items found similar to "Spin Doctors Two Princes Off my Line 7 inch vinyl single EXCELLENT"
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+ £3.60 postage	Spin Doctors - Two Princes 2 Track CD Single From Australia
+ £4.96 postage	SPIN DOCTORS-TWO PRINCES-OFF MY LINE(LIVE)1992-1ST-EX+
+ £5.20 postage	Vintage Music Cassette Tape SPIN DOCTORS Two Princes / Off My Line (LIVE) EPIC
Spin Doctors - Two Princes Promo Cd Single
+ £5.50 postage	SPIN DOCTORS - Two Princes, CD Single, 1992
Spin Doctors Two Princes CD Single
+ £3.70 postage	cd-single, Spin Doctors - Two Princes, 2 Tracks
+ £3.33 postage	SPIN DOCTORS "TWO PRINCES" AUSSIE CD SINGLE NM
+ £4.16 postage	THE SPIN DOCTORS Two Princes CD Single 1993 Epic / Sony 659031 2
Spin doctors-Two princes-1991 cd single
+ £3.50 postage	SPIN DOCTORS - Two Princes (UK 3 Track CD Single)
+ £4.00 postage	Spin Doctors - Two Princes - UK CD Single
+ £5.89 postage	SPIN DOCTORS Two Princes CD single Epic 6591452
SPIN DOCTORS - TURN IT UPSIDE DOWN/TWO PRINCES - CASSETTES
+ £6.00 postage	Spin Doctors - Pocket Full of Kryptonite (CD 1997) "Two Princes" £2.99
+ £5.50 postage	Spin Doctors Two Princes CD Single Epic Recs
+ £5.50 postage	Spin Doctors Two Princes UK CD Single
+ £5.00 postage	SPIN DOCTORS Two Princes CD 3 Tracks Inc Off My Line+Rosetta Stone, Both Live
+ £3.30 postage	SPIN DOCTORS - TWO PRINCES - CASSETTE TAPE SINGLE
+ £3.69 postage	SPIN DOCTORS - TWO PRINCES - CASSETTE TAPE SINGLE
+ £3.69 postage	Two Princes, Spin Doctors, Good Single, Import
SPIN DOCTORS two princes CD 3 track b/w live versions of off my line and rosetta
+ £1.45 postage	Spin Doctors - Two Princes / Off My Line / Rosetta Stone (CD Single)
+ £4.99 postage	Spin Doctors Two Princes CD single (CD5 / 5") Austrian 6591452 EPIC 1991
+ £0.95 postage	SPIN DOCTORS - CD Single - Two Princes
+ £6.50 postage	Spin Doctors - Two Princes - Little Miss Can´t Be Wrong - Single - 7"
+ £3.18 postage	Spin Doctors : Two Princes CD 1 CD, Fully guaranteed, dispatched within 2 days
+ £1.50 postage	SPIN DOCTORS 'TWO PRINCES' 3-TRACK CD SINGLE
+ £4.00 postage	SPIN DOCTORS Pocket Full Of Kryptonite CD Album Epic 1992
+ £5.20 postage	SPIN DOCTORS TWO PRINCES 2 TRACK OZ PRESSING CD - EXCELLENT
+ £3.60 postage	Spin Doctors – Two Princes_7" Vinyl Record_Classic Alternative Rock
TWO PRINCES - SPIN DOCTORS cd
+ £8.31 postage	SPIN DOCTORS - POCKET FULL OF KRYPTONITE (1997 CD ALBUM) EXCELLENT CONDITION
+ £5.00 postage	Spin Doctors Two Princes Music Cassette Epic Label £3.99
+ £4.30 postage	SPIN DOCTORS - POCKET FULL OF KRYPTONITE CD ALBUM
+ £5.00 postage	Spin Doctors - Pocket Full of Kryptonite (1997)
Newly listedSpin Doctors - Pocket Full of Kryptonite (1997)
+ £5.50 postage	Spin Doctors - Pocket Full of Kryptonite (1997) - CD ALBUM.
Spin Doctors - Pocket Full of Kryptonite (1997 cd )
+ £6.00 postage	Spin Doctors - Pocket Full of Kryptonite (1997) - CD
+ £5.30 postage	Spin Doctors: Pocket Full Of Kryptonite CD
Playlist:very Best of Spin Doctors - Doctors Spin New & Sealed CD Free Shipping

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