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Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. - PubMed - NCBI
1 selected item: 16327776
Nature. 2006 Jan 19;439(7074):344-8. Epub 2005 Dec 4.
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population.
Vignuzzi M1, Stone JK, Arnold JJ, Cameron CE, Andino R.
Department of Microbiology and Immunology, University of California, San Francisco, California 94143-2280, USA.
An RNA virus population does not consist of a single genotype; rather, it is an ensemble of related sequences, termed quasispecies. Quasispecies arise from rapid genomic evolution powered by the high mutation rate of RNA viral replication. Although a high mutation rate is dangerous for a virus because it results in nonviable individuals, it has been hypothesized that high mutation rates create a 'cloud' of potentially beneficial mutations at the population level, which afford the viral quasispecies a greater probability to evolve and adapt to new environments and challenges during infection. Mathematical models predict that viral quasispecies are not simply a collection of diverse mutants but a group of interactive variants, which together contribute to the characteristics of the population. According to this view, viral populations, rather than individual variants, are the target of evolutionary selection. Here we test this hypothesis by examining the consequences of limiting genomic diversity on viral populations. We find that poliovirus carrying a high-fidelity polymerase replicates at wild-type levels but generates less genomic diversity and is unable to adapt to adverse growth conditions. In infected animals, the reduced viral diversity leads to loss of neurotropism and an attenuated pathogenic phenotype. Notably, using chemical mutagenesis to expand quasispecies diversity of the high-fidelity virus before infection restores neurotropism and pathogenesis. Analysis of viruses isolated from brain provides direct evidence for complementation between members in the quasispecies, indicating that selection indeed occurs at the population level rather than on individual variants. Our study provides direct evidence for a fundamental prediction of the quasispecies theory and establishes a link between mutation rate, population dynamics and pathogenesis.
PMC1569948
A restricted quasispecies of poliovirus is less neuropathogenic. a–b, Percentage of mice surviving intramuscular injection of different doses (107, 108, 109 PFU) of the narrow G64S (a) or the expanded G64SeQS populations (b) as compared to wildtype (WT, open symbols, only one dose, 107 PFU is shown). The number of mice per group was 20 (n=20). The differences observed between WT (107 PFU) and G64S (107, 108, 109 PFU) or the expanded G64SeQS (107 PFU) are statistically significant (P<0.001). In contrast, no statistically significant difference was observed between WT (107 PFU) and G64SeQS (108 PFU) (p>0.5). c, Calculation of LD50 values for each viral stock using the Reed and Muench method.
Quasispecies diversity determines pathogenesis through cooperative interactions within a viral population
Nature. ;439(7074):344-348.
Genomic diversity in a quasispecies is critical in viral tissue tropism and pathogenesis. a–b, Virus titers in PFU/gram from tissue of mice infected intravenously with the wildtype virus population (squares), the narrow G64S quasispecies (circles in a) or the artificially expanded G64SeQS quasispecies (circles in b). Mean values ± s.d. of 3 experiments are shown.
Cooperative interactions among members of the virus population link quasispecies diversity with pathogenesis. a, Subpopulations of viruses isolated from brain of infected mice cannot re-establish CNS infection if the diversity of the quasispecies is restricted. Virus titers (PFU/g) from muscle, brain and spinal cord of mice infected intravenously for 4 days with 107 PFU viruses isolated from brains of infected animals with wildtypeb, G64Sb, G64seQS-b. On top, schematic representation of the protocol of re-inoculation is shown. b, Neurotropic virus populations facilitate entry and replication of a non-neurotropic virus into the CNS. i) schematic representation of an in vivo complementation experiment. G64SSac is a narrow quasispecies carrying a higher fidelity polymerase (G64S allele) and a silent mutation that introduces a Sac I site at nucleotide 1906 within the capsid region. This neutral genetic marker can be used as “bar-code”. Mice were infected intravenously with either G64SSac alone (2x108 PFU per animal) or co-injected with wildtype (WT) or G64SeQS at 1:1 ratios (108 PFU each virus per animal). Viruses were re-isolated from brain tissues, through infection of HeLa cells, and their RNA was analyzed by RT-PCR. ii) All PCR products were digested with Sac I prior agarose gel electrophoresis analysis. DNA obtained from wildtype or G64SeQS viruses are not digested by Sac I (~3 kb fragment); whereas the PCR product from the G64SSac virus generated two smaller bands (~1450 and 1350 kb) when digested with Sac I. On top of lanes virus injected into each mouse are indicated. Each lane corresponds to one infected mouse. Arrows on the left indicate full-length RT-PCR products and Sac1 digested PCR fragments. DNA markers (kb) are shown (M).
U01 AI054776/AI/NIAID NIH HHS/United States


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Advertisementad feedback	ad feedback	Kay and Duane Douglass (#47176403)	member for 7 years, 8 months, 25 days
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CRBTransferThank you so much for transferring my Uncle's record to me! It was a wonderful surprise. Thank you, also, for updating the information before hand!! This is very much appreciated!Added by CRB on May 26, 2017 5:37 PMSusan GrantWang TransferI was very surprised and happy to see that you have transferred the baby and Martin to me. You are SO kind and thoughtful, words cannot express.Added by Susan Grant on May 21, 2017 9:04 PMSusan GrantTrout Lake cemeteryThank you for all your hard work with this cemetery.Added by Susan Grant on May 21, 2017 5:06 PMDwightTransfer of Memorial# 90073772Thank you for transferring Carol Jean (Schmidt) Billington's memorial to me. Her maternal grandmother, Ida Belle DeArmoun was the daughter of Samuel Kennedy DeArmoun, nephew of my 4x great-grandfather.Added by Dwight on May 08, 2017 9:22 AMWatersproutG.W. Duvall in Kalama IOOFThank you for the transfer!Added by Watersprout on Apr 29, 2017 11:23 AMPeter Joseph ("PJ") BraunTransfer of five memorials in Saint Mary Cemetery, Hood River, ORJust a quick note of appreciation... I was in this cemetery for the interment of the spouse of a 1C1R so I brought along my camera (like I imagine you do quite frequently) and took photos of all the military markers I could see... PLUS any of the "cool" old style markers. When I saw you had created Find A Grave memorials for them already, I just jumped into Ancestry.com & some other sites to see if I could find some life details to add.You really didn't need to transfer them over to me; I have no "family claim"... but I am honored by your trust in me to "do right" by these folks. I'll continued digging and see if I can't find any more information to add... to better tell their life story.Namasté, "PJ" Braun, ETCM/USN (retired)Added by Peter Joseph ("PJ") Braun on Apr 27, 2017 12:01 PMClarice CourneyaWilliam Terry-63469397Kay and Duane-thank you for transferring William to my care-his life ended quite sadly. I have requested that his two children be linked to him. Mary Ann (Terry) Pollan-63661359 and George William Terry-142061743.I like to link all family members, if possible.Thanks again.Clarice Courneya46550274Added by Clarice Courneya on Apr 25, 2017 12:23 PMShelby JonesAbout Orville CummingsI see you have added Orville Cummings to Find a Grave. Do you know if you are related to him because his sister is my great grandmother. So I was curious if you had anything to do with this person.Added by Shelby Jones on Apr 06, 2017 9:06 AMRobMinteer57140564164After getting pictures yesterday in our local cemetery, I looked back through some of my records of other additions and projects there through the years, and found mention that you had transferred this one to me.The City upgraded their Website fairly recently, so out of curiosity I searched and found her, showing as being buried just a week after I had checked the printed records. It's odd that the newspaper had stated that she WAS buried here, not that she would be...Anyway, I'll be glad to transfer her back to you if you want. I'll get a picture next time I have a list of pics to get. Her mother is listed under her second married name, which could possibly lead to a duplicate someday.Added by RobMinteer57 on Mar 25, 2017 7:09 AMKathy Stroope VeaseyGriffith transfersThanks so muchAdded by Kathy Stroope Veasey on Mar 15, 2017 8:47 AM[View all messages...] Privacy Statement and Terms of Service ad feedback

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Patent US6728757 - Smart HTML electronic mail - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe smart Hypertext Markup Language (HTML) electronic mail system utilizes an intelligent decision algorithm to decide if an addressee is HTML capable or if plain text is required. The user specifies if certain e-mail domains, newsgroups, and individual e-mail addresses are HTML-capable or require plain...http://www.google.com/patents/US6728757?utm_source=gb-gplus-sharePatent US6728757 - Smart HTML electronic mailAdvanced Patent SearchPublication numberUS6728757 B1Publication typeGrantApplication numberUS 09/090,990Publication dateApr 27, 2004Filing dateJun 4, 1998Priority dateJun 4, 1998Fee statusPaidPublication number09090990, 090990, US 6728757 B1, US 6728757B1, US-B1-6728757, US6728757 B1, US6728757B1InventorsJohn L. FriendOriginal AssigneeAmerica Online, IncorporatedExport CitationBiBTeX, EndNote, RefManPatent Citations (7), Non-Patent Citations (2), Referenced by (11), Classifications (7), Legal Events (5) External Links: USPTO, USPTO Assignment, EspacenetSmart HTML electronic mail
US 6728757 B1Abstract
The smart Hypertext Markup Language (HTML) electronic mail system utilizes an intelligent decision algorithm to decide if an addressee is HTML capable or if plain text is required. The user specifies if certain e-mail domains, newsgroups, and individual e-mail addresses are HTML-capable or require plain text e-mail or the invention will query directory servers such as Lightweight Directory Access Protocol (LDAP) servers as to the HTML capabilities of an e-mail client. The user composes an HTML e-mail document, indicating the addressees in the �to� field and selects the �send� command, the invention examines the document and, if the addressee is known to be HTML-capable, the document is transmitted as is. If the addressee is not known to be HTML-capable and if the document does not contain any HTML formatting that cannot be easily rendered in plain text, the invention automatically converts the document to plain text and transmits the document, thereby taking full advantage of the rich text formatting of HTML. If the document does contain any HTML features that are unique, the invention asks the user if he wants to send the document as is or have it converted over to plain text before sending, thereby providing a smart HTML e-mail system that automatically and intelligently converts and distributes the user's e-mail documents to both HTML-capable and plain text e-mail clients.
What is claimed is: 1. A process for sending Hypertext Markup Language (HTML) formatted electronic mail across a computer network, comprising the steps of:
creating an HTML document; checking the designated recipients for HTML capability; and sending said document to said designated recipients in accordance with said recipient's HTML capability. 2. The process of claim 1, wherein said checking step checks if all of said designated recipients are known to be HTML-capable and if all of said designated recipients are HTML-capable, sending said document in HTML format.
querying a directory server across said computer network for the HTML capability of each of said designated recipients whose HTML capabilities are unknown. 15. The process of claim 1, further comprising the step of:
recording the HTML capabilities of recipients in an address book or recipient list. 16. An apparatus for sending Hypertext Markup Language (HTML) formatted electronic mail across a computer network, comprising:
means for creating an HTML document; means for checking the designated recipients for HTML capability; and means for sending said document to said designated recipients in accordance with said recipient's HTML capability. 17. The apparatus of claim 16, wherein said checking means checks if all of said designated recipients are known to be HTML-capable and if all of said designated recipients are HTML-capable, sends said document in HTML format.
means for querying a directory server across said computer network for the HTML capability of each of said designated recipients whose HTML capabilities are unknown. 30. The apparatus of claim 16, further comprising:
The user composes an HTML e-mail document, indicating the addressees in the �to� field. When the user selects the �send� command, the invention utilizes an intelligent decision algorithm to decide if an addressee is HTML capable or if plain text is required. It examines the document and, if the addressee is known to be HTML-capable, the document is transmitted as is.
With respect to FIG. 6, the user specifies the capabilities of individual recipients and domains in a recipient window 601. Individual e-mail addresses, newsgroups, and e-mail domain names are entered into either the �Does not prefer HTML� area 603 or the �Prefers HTML� area 608. Entries are easily switched between the two areas by clicking on the �Add� button 602 to move entries from the �Does not prefer HTML� area 603 to the �Prefers HTML� area 608 or by clicking on the �Remove� button 605 to move entries from the �Prefers HTML� area 608 to the �Does not prefer HTML� area 603. The updated entries are saved by clicking on the �OK� button 604 or changes are ignored by clicking on the �Cancel� button 606.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS5283887 *Dec 19, 1990Feb 1, 1994Bull Hn Information Systems Inc.Automatic document format conversion in an electronic mail system based upon user preferenceUS5630060 *May 1, 1995May 13, 1997Canon Kabushiki KaishaMethod and apparatus for delivering multi-media messages over different transmission mediaUS5706434 *Jul 6, 1995Jan 6, 1998Electric Classifieds, Inc.Integrated request-response system and method generating responses to request objects formatted according to various communication protocolsUS5826062 *May 30, 1996Oct 20, 1998International Business Machines CorporationMethod and apparatus for converting and displaying a multimedia document at a clientUS5872926 *May 31, 1996Feb 16, 1999Adaptive Micro Systems, Inc.Integrated message systemUS5911776 *Dec 18, 1996Jun 15, 1999Unisys CorporationAutomatic format conversion system and publishing methodology for multi-user networkUS6094684 *Apr 2, 1997Jul 25, 2000Alpha Microsystems, Inc.Method and apparatus for data communication* Cited by examinerNon-Patent CitationsReference1 *Berners-Lee, et al.; Request for Comments (RFC) 1866, "Hypertex Markup Language-2.0", Nov. 1995.2Berners-Lee, et al.; Request for Comments (RFC) 1866, "Hypertex Markup Language�2.0", Nov. 1995.* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS6952279 *May 20, 1999Oct 4, 2005Panasonic Communications Co., Ltd.Network facsimile apparatusUS7320019 *Nov 30, 2000Jan 15, 2008At&T Delaware Intellectual Property, Inc.Method and apparatus for automatically checking e-mail addresses in outgoing e-mail communicationsUS7373602 *May 28, 2003May 13, 2008Microsoft CorporationMethod for reading electronic mail in plain textUS7391526 *Apr 26, 2001Jun 24, 2008Sony CorporationInformation processing apparatus and method, information processing system and medium used in transmitting/receiving an E-mail with a file attached theretoUS7657838 *Apr 7, 2003Feb 2, 2010At&T Intellectual Property I, L.P.Preventing execution of programs that are embedded in email messagesUS8149436Jun 6, 2005Apr 3, 2012Panasonic System Networks Co., Ltd.Network facsimile apparatusUS8219815Dec 17, 2007Jul 10, 2012Ca, Inc.Information management systemUS8239463Jan 15, 2008Aug 7, 2012At&T Intellectual Property I, L.P.Method and apparatus for automatically checking E-mail addresses in outgoing E-mail communicationsUS8281247Dec 15, 2009Oct 2, 2012At&T Intellectual Property I, L.P.Preventing execution of programs that are embedded in email messagesUS20080072074 *Aug 27, 2007Mar 20, 2008Fujitsu LimitedInformation-protection device, information-protection system, information-protection method, and program-storage medium storing information protection programEP1435710A2 *Nov 27, 2003Jul 7, 2004Microsoft CorporationSystem and method for improved client server communications of email messages* Cited by examinerClassifications U.S. Classification709/206International ClassificationG06F15/16, H04L12/58Cooperative ClassificationH04L12/5835, H04L51/066European ClassificationH04L51/06B, H04L12/58C2Legal EventsDateCodeEventDescriptionSep 14, 2011FPAYFee paymentYear of fee payment: 8Nov 16, 2010ASAssignmentOwner name: GOING INC, MASSACHUSETTSFree format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Effective date: 20100930Owner name: MAPQUEST, INC, COLORADOFree format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Effective date: 20100930Owner name: TRUVEO, INC, CALIFORNIAFree format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Effective date: 20100930Free format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Owner name: TACODA LLC, NEW YORKEffective date: 20100930Free format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Owner name: NETSCAPE COMMUNICATIONS CORPORATION, VIRGINIAEffective date: 20100930Free format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Effective date: 20100930Owner name: AOL ADVERTISING INC, NEW YORKEffective date: 20100930Owner name: LIGHTNINGCAST LLC, NEW YORKFree format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Effective date: 20100930Owner name: AOL INC, VIRGINIAFree format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Free format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Effective date: 20100930Owner name: SPHERE SOURCE, INC, VIRGINIAEffective date: 20100930Owner name: YEDDA, INC, VIRGINIAFree format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Free format text: TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS;ASSIGNOR:BANK OF AMERICA, N A;REEL/FRAME:025323/0416Effective date: 20100930Owner name: QUIGO TECHNOLOGIES LLC, NEW YORKDec 14, 2009ASAssignmentOwner name: BANK OF AMERICAN, N.A. 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Surinder Kaur | eBay Please enable JavaScript Our new search experience requires JavaScript to be enabled. Please enable JavaScript on your browser, then try again.
Skip to main contenteBayShop by categoryEnter your search keywordAll CategoriesAntiquesArtBabyBooksBusiness & IndustrialCameras & PhotoCell Phones & AccessoriesClothing, Shoes & AccessoriesCoins & Paper MoneyCollectiblesComputers/Tablets & NetworkingConsumer ElectronicsCraftsDolls & BearsDVDs & MovieseBay MotorsEntertainment MemorabiliaGift Cards & CouponsHealth & BeautyHome & GardenJewelry & WatchesMusicMusical Instruments & GearPet SuppliesPottery & GlassReal EstateSpecialty ServicesSporting GoodsSports Mem, Cards & Fan ShopStampsTickets & ExperiencesToys & HobbiesTravelVideo Games & ConsolesEverything ElseAdvanced or register':' style="margin-right:3px">Hi -User-!'.replace(/-User-/,escape(a)))+"")}catch(b){document.write("")}})();Hi (Sign in to bid or buy) Daily Deals Gift Cards Sell Help & Contact My eBayExpand My eBay Summary Bids/Offers Watch list Wish list All lists Purchase history Selling My Collections Followed searches MessagesNotification Refine your search for Surinder Kaur
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Surinder Kaur: Did you mean: surrender kaur? (3 items)
Vintage Collection: Surinder Kaur (Saregama) (RPG) India - '1st Edition'
NEW Psychological Concepts and Psychotherapy in Yoga Darshan by Dr Surinder Kaur
Psychological Concepts and Psychotherapy in Yoga Darshan by Surinder Kaur and...
Psychological Concepts and Psychotherapy in Yoga Darshan by Dr Surinder Kaur
ASA SINGH MASTANA & SURINDER KAUR -MAINU HEERE HE. - CD
(839W) Surinder Kaur, Punjab Di Rooh - CD
Bemisaal Parkash Kaur & Surinder Kaur / 2 CD SET / Best Punjabi Old Songs
Wasted Talent in the Bluest Eye by Toni Morrison by Surinder Kaur (2015,...
Wasted Talent in the Bluest Eye by Toni Morrison by Surinder Kaur
Asa Singh Mastana and Surinder Kaur in Concert DVD LIVE IN CONCERNT
Construction Mathematics by Surinder Virdi, Roy Baker and Narinder Kaur Virdi...
PRAKASH KAUR AND SURINDER KAUR PUNJABI FOLK rare EP RECORD 45 INDIA 1968 VG+
PRAKASH KAUR SURINDER KAUR PUNJABI bhangra rare EP RECORD 45 INDIA 1968 VG+
Construction Mathematics, Virdi, Narinder Kaur, Baker, Roy, Virdi, Surinder, Ver
PRAKASH SURINDER KAUR PUNJABI N 94214 RARE 78 RPM RECORD 10" INDIA VG+
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FOLK MUSIC OF PUNJAB PRAKASH KAUR & SURINDER KAUR ASA SINGH PUNJABI EP 1968 VG
Psychological Concepts and Psychotherapy in Yoga Darshan by Dr. Surinder Kaur
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text:
Robert Riddle Condolences | The Cincinnati Enquirer
Robert "RB" Riddle
Thank you for signing the Guest Book for Robert "RB" Riddle.
Please take a moment to sign the Guest Book for Robert "RB" Riddle.
I considered Bob a friend. He helped me through a very tough time in my life. A pleasure to have known him. Thoughts and prayers to the family.
Mark G., Ludlow, KY
Susan Hatter, Lexington, KY
Oh so many wonderful memories of Bobert. He will be greatly missed. When I was at the lowest point in my life he bought me an oar. An oar, you ask. Yes, an oar. To Bobert, (that's what I called him), it was to show me as long as I had that oar that it represented that he and Judy were my oar and I'd never be rowing through life alone that they would always be there for me. That's the kind of heart Bobert had. Will miss you Bobert but will see you again when God calls me home.
Marlene Senn, Lebanon, OH
Send me a daily email when updates are made to the obituary or Condolence page for Robert "RB" Riddle.

value: This website is a United States-based website founded in 1998, the world's largest commercial provider of online memorials. The Web site hosts obituaries and memorials for more than 70 percent of all U.S. deaths.


text:
A Jerusalem hospital where Palestinian babies die alone | World news | The Guardian
Israeli blockade on Gaza means parents are separated from critically ill children
Thu 20 Jun 2019 00.00 EDT Last modified on Fri 21 Jun 2019 08.00 EDT
The neonatal intensive care unit in Makassed hospital in East Jerusalem. Photograph: Quique Kierszenbaum
Hiba Swailam, 24, carrying her five-month-old baby in Beit Lahia. Photograph: Wissam Nassar/The Guardian
Shahad Swelem Photograph: Wissam Nassar/The Guardian
The surviving child, Shahad, spent the first months of her life cared for by nurses, and Hiba could only see her daughter in video calls. While the baby was ready for discharge since February, no family member was able to pick her up.
The truth is out about Israel’s lethal actions in Gaza. Will the world listen? | Saeb Erekat
Physicians for Human Rights-Israel, an Israeli medical non-profit, said more than 7,000 permits were issued for minors from Gaza last year. Less than 2,000 permits for parents were granted, suggesting most children travelled without their mothers and fathers. Mor Efrat, the group’s director for the occupied Palestinian territories, said “the Israeli government should be held accountable for the human suffering”.
Separating sick infants from their parents can have devastating impacts. Doctors believed one of the triplets who died when their mother was in Gaza had a condition for which one of the best preventative steps is breastfeeding. “I wouldn’t say that if the mother was there, they wouldn’t get it, but it would decrease the chances,” said Hatem Khammash, the head of the neonatal unit.
Hiba Swailam carrying her daughter Shahad, with husband Mohammad and her mother in law Khadra in Beit Lahia. Photograph: Wissam Nassar/The Guardian
To the families’ relief, Makassed eventually discharged Khalil after a month, and the baby could return back to Gaza. But when he did, they found the medication was locally unavailable. “The swelling was increasing,” his father said. He decided to try to leave Gaza to the south via Egypt, which also imposes a blockade but allows travel in certain cases. “The day we were supposed to travel, he died.”
Cogat, the defence ministry body responsible for coordinating Israeli government activity in the Palestinian territories, said in a written response that it had no age limits for permits and every request was examined individually.
The neonatal intensive care unit in Al Makassed hospital in East Jerusalem. Photograph: Quique Kierszenbaum
While it is harder for people in Gaza to exit, Makassed also serves the West Bank, and Palestinian parents there also find it difficult, sometimes impossible, to get to the hospital. Israel claims sovereignty over all of Jerusalem and has isolated even its majority Arab neighbourhoods from the rest of the Palestinian territories. Some patients, many older children with cancer, have families who live just minutes away but cannot visit.
Gulf state reveals funding plan after ceasefire ends latest Israeli-Palestinian hostilities
Three-day battle killed 23 in Gaza, including two pregnant women, and four in Israel
Air and tank strikes kill 19 Palestinians after Netanyahu orders ‘massive attacks’, while rockets kill four in Israel
Six killed in Gaza as Israel responds to multiple rocket attacks
An infant and her pregnant mother among Palestinian dead and one Israeli man killed as ceasefire falters

value: This website is a British news and media website owned by the Guardian Media Group. It contains nearly all of the content of the newspapers The Guardian and The Observer, as well as a substantial body of web-only work produced by its own staff, including a rolling news service.


text:
Free newspapers in lobby Fitness facilities Coffee shop or café Limo or Town Car service available Safe-deposit box at front desk Multilingual staff Express check-in Total number of rooms - 330 24-hour front desk Porter/bellhop Express check-out Number of floors - 12 ATM/banking Gift shops or newsstand Dry cleaning/laundry service Coffee/tea in common areas Television in common areas Elevator/lift Number of bars/lounges - 2 Breakfast available (surcharge) Wedding services Concierge services Tours/ticket assistance Free WiFi Wired (high-speed) Internet access - surcharge Airport transportation Luggage storage Shopping on site Valet parking (surcharge) Terrace Self parking (surcharge) Number of restaurants - 4 24-hour business center Conference space size (feet) - 17800 Conference space size (meters) - 1654 Number of meeting rooms - 11 Smoke-free property Show all hotel amenities
Premium TV channels Hypo-allergenic bedding available Premium bedding Separate sitting area Room service (limited hours) Air conditioning In-room climate control (air conditioning) Blackout drapes/curtains Phone Refrigerator Coffee/tea maker Designer toiletries Free toiletries Hair dryer Iron/ironing board Daily housekeeping Desk Flat-panel TV HDTV Sofa bed WiFi (surcharge) Wired high-speed Internet access (surcharge) Cable TV service Separate living room In-room safe Sofa bed size Free cribs/infant beds Separate bedroom Show all room amenities
Marketstreet - Open for breakfast daily, this cozy restaurant offers both à la carte items and a buffet. The Parkview Café - Located in the lobby, this café features coffee, cappuccino, and espresso, as well as cocktails in the evening. Lunch and dinner are also offered.

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text:
Dunlop HEVEA DEE Unisex Half Length Wide Calf Wellington Boots Wellies Black | eBay
Details about Dunlop HEVEA DEE Unisex Half Length Wide Calf Wellington Boots Wellies Black
shuperb (171261 )
- Select - UK 4 UK 5 UK 6 UK 6.5 UK 7 UK 8 UK 9 UK 10 UK 11 UK 12
GBP 15.00 (approx. US $20.21) Expedited Shipping | See details
Estimated between Wed. May. 23 and Mon. Jun. 4
260903285946
Last updated on May 09, 2018 22:05:13 PDT View all revisions
Lining: Unlined Main Colour: Blacks
Sole: PVC Upper Material: Rubber
Wellington Extra Wide (EE +) Boots for Men,
Wellington Wide (E, W) Boots for Men,
Daniel Wellington Unisex Wristwatches,
Wellington Boots Men's Rainboots,


text:
ahbadgerbadgerbadger comments on TIL that a 2005 study found that the scores of "wine experts" are essentially meaningless, revealing that a typical judge's scoring of a wine varied by plus/minus four points over three blind tastings poured from the same bottle.jump to contentmy subredditsannouncementsArtAskRedditaskscienceawwblogbookscreepydataisbeautifulDIYDocumentariesEarthPornexplainlikeimfiveFitnessfoodfunnyFuturologygadgetsgamingGetMotivatedgifshistoryIAmAInternetIsBeautifulJokesLifeProTipslistentothismildlyinterestingmoviesMusicnewsnosleepnottheonionOldSchoolCoolpersonalfinancephilosophyphotoshopbattlespicsscienceShowerthoughtsspacesportstelevisiontifutodayilearnedTwoXChromosomesUpliftingNewsvideosworldnewsWritingPromptsedit subscriptionsfront-all-random | philosophy-nosleep-space-AskReddit-television-news-Fitness-pics-InternetIsBeautiful-todayilearned-funny-books-personalfinance-gaming-history-gifs-photoshopbattles-Jokes-IAmA-nottheonion-listentothis-Art-dataisbeautiful-WritingPrompts-EarthPorn-GetMotivated-Futurology-Documentaries-creepy-OldSchoolCool-explainlikeimfive-LifeProTips-movies-askscience-sports-mildlyinteresting-worldnews-aww-science-Showerthoughts-videos-Music-tifu-food-gadgets-TwoXChromosomes-DIY-UpliftingNewsmore » todayilearnedcommentsrelatedwant to join? login or register in seconds|Englishlimit my search to /r/todayilearneduse the following search parameters to narrow your results:subreddit:subredditfind submissions in "subreddit"author:usernamefind submissions by "username"site:example.comfind submissions from "example.com"url:textsearch for "text" in urlselftext:textsearch for "text" in self post contentsself:yes (or self:no)include (or exclude) self postsnsfw:yes (or nsfw:no)include (or exclude) results marked as NSFWe.g. subreddit:aww site:imgur.com dogsee the search faq for details.advanced search: by author, subreddit...this post was submitted on 15 Oct 20132,638 points (93% upvoted)shortlink: remember mereset passwordloginSubmit a new linktodayilearnedunsubscribesubscribe6,849,341 readers6,256 users here nowNew to reddit? Click here!
a community for 5 yearsmessage the moderatorsMODERATORSnix0nwacroverrelic2279lukemcrmanbraGeekymummasdnroger_Lynda73lanismycousinSo yummy!...and 11 more »263726382639TIL that a 2005 study found that the scores of "wine experts" are essentially meaningless, revealing that a typical judge's scoring of a wine varied by plus/minus four points over three blind tastings poured from the same bottle. (theguardian.com)submitted 1 year ago by [deleted]1214 commentssharecancelsorry, this has been archived and can no longer be voted onloading...sorted by: bestbesttopnewhotcontroversialoldrandomyou are viewing a single comment's thread.view the rest of the comments →[–]ahbadgerbadgerbadger 40 points41 points42 points 1 year ago (10 children)sorry, this has been archived and can no longer be voted onI am this kind.
permalinkparent[–]Seldain 50 points51 points52 points 1 year ago (9 children)sorry, this has been archived and can no longer be voted onYes you are.
permalinkparent[–]DubstepCheetah 39 points40 points41 points 1 year ago (5 children)sorry, this has been archived and can no longer be voted onwhat
permalinkparent[–]Intolight 40 points41 points42 points 1 year ago (4 children)sorry, this has been archived and can no longer be voted onWas there a glitch in the matrix?
permalinkparent[–]Thorrtun 27 points28 points29 points 1 year ago (3 children)sorry, this has been archived and can no longer be voted onWhoooa dude.
permalinkparent[–]DmitryStrelnikov 1 point2 points3 points 1 year ago (2 children)sorry, this has been archived and can no longer be voted onwat
permalinkparent[–]elCharderino 1 point2 points3 points 1 year ago (1 child)sorry, this has been archived and can no longer be voted onJust go with it
permalinkparent[–]DmitryStrelnikov 1 point2 points3 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted oninteresting.
permalinkparent[+]yolowolf comment score below threshold-7 points-6 points-5 points 1 year ago (2 children)sorry, this has been archived and can no longer be voted onhttp://img.pandawhale.com/57220-Oprah-you-get-an-upvote-m5Kh.jpeg
permalinkparent[–]randothemagician 0 points1 point2 points 1 year ago (1 child)sorry, this has been archived and can no longer be voted onI clicked your link soley because I thought it would be the oprah-bees gif with upvote arrows instead of bees. I am disappoint.
permalinkparent[–]yolowolf 0 points1 point2 points 1 year ago (0 children)sorry, this has been archived and can no longer be voted onI am deeply apologetic for this loss of service. It is temporary and we are working to restore normal yolowolf conditions. Thank you for your understanding.
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text:
Patent US7178050 - System for highly available transaction recovery for transaction processing ... - Google Patents
A highly available transaction recovery service migration system in accordance with one embodiment of the present invention implements a server's Transaction Recovery Service (TRS) as a migratable service. In one embodiment of the present invention, the TRS is a server instance or software module implemented...http://www.google.com/patents/US7178050?utm_source=gb-gplus-sharePatent US7178050 - System for highly available transaction recovery for transaction processing systems
Publication number US7178050 B2
Application number US 10/341,041
Also published as US7380155, US7406618, US20030163755, US20060129872, US20070136393, US20080162593, US20080228839
Publication number 10341041, 341041, US 7178050 B2, US 7178050B2, US-B2-7178050, US7178050 B2, US7178050B2
Patent Citations (26), Referenced by (73), Classifications (15), Legal Events (4)
US 7178050 B2
MigratableServiceCoordinatorRuntimeMBean msc=
// Obtain the MigratableTargetMBean of the server whose Transaction Recovery Service needs to be migrated
ServerMBean server1=(ServerMBean)
Admin.getMBeanHome( ).getConfigurationMBean(“server1”, “MigratableTargetConfig”);
MigratableTargetMBean mt=server1.getJTAMigratableTarget( );
// Obtain the configuration ServerMBean of the server to which the Transaction Recovery Service will be migrated
ServerMBean server2=(ServerMBean)
Admin.getMBeanHome( ).getConfigurationMBean(“server2”, “MigratableTargetConfig”);
// Perform the migration of Transaction Recovery Service of “server1” to “server2”
msc.migrateJTA(mt, server2, false /*source up*/,false /*destination up*/);
US6877111 * Mar 26, 2001 Apr 5, 2005 Sun Microsystems, Inc. Method and apparatus for managing replicated and migration capable session state for a Java platform
US7526676 * Sep 3, 2004 Apr 28, 2009 Avago Technologies General Ip (Singapore) Pte. Ltd. Slave device having independent error recovery
US7739546 * Oct 20, 2006 Jun 15, 2010 Netapp, Inc. System and method for storing and retrieving file system log information in a clustered computer system
US8458696 Aug 25, 2009 Jun 4, 2013 Samsung Electronics Co., Ltd. Managing process migration from source virtual machine to target virtual machine which are on the same operating system
US9477499 May 10, 2013 Oct 25, 2016 Samsung Electronics Co., Ltd. Managing process migration from source virtual machine to target virtual machine which are on the same operating system
US20100153674 * Aug 25, 2009 Jun 17, 2010 Park Seong-Yeol Apparatus and method for managing process migration
U.S. Classification 714/4.11, 714/E11.131, 714/15, 707/999.202
International Classification G06F11/00, G06F11/14, H04L1/22
Cooperative Classification G06F11/2046, G06F11/2038, G06F11/2028, G06F11/1662, H04L1/22, Y10S707/99953
European Classification G06F11/14A14, H04L1/22
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FUNG, PRISCILLA C.;SOMOGYI, ALEXANDER J.;REEL/FRAME:013988/0982;SIGNING DATES FROM 20030322 TO 20030403


text:
The Naked Trader: How Anyone Can Make Money Trading Shares by Robbie Burns (Paperback, 2011) | eBay
Publisher: Harriman House ISBN 13: 9780857191700. Title: The Naked Trader: How anyone can make money trading shares Item Condition: used item in a good condition. Will be clean, not soiled or stained.
Sold bycmedia_group (223551)99.8% positive FeedbackContact seller
item 1 The Naked Trader: How anyone can make money trading shares By R .9780857191700 -The Naked Trader: How anyone can make money trading shares By R .9780857191700
item 2 The Naked Trader: How anyone can make money trading shares,Rob ,.9780857191700 -The Naked Trader: How anyone can make money trading shares,Rob ,.9780857191700
item 3 The Naked Trader: How anyone can make money trading shares by Burns, Robbie The -The Naked Trader: How anyone can make money trading shares by Burns, Robbie The
item 4 The Naked Trader: How anyone can make money trading shares by Burns, Robbie The -The Naked Trader: How anyone can make money trading shares by Burns, Robbie The
item 5 The Naked Trader: How anyone can make money trading shares, Burns, Robbie, Very -The Naked Trader: How anyone can make money trading shares, Burns, Robbie, Very
item 6 The Naked Trader: How anyone can make money trading shares-ExLibrary -The Naked Trader: How anyone can make money trading shares-ExLibrary
item 7 The Naked Trader: How anyone can make money trading shares -The Naked Trader: How anyone can make money trading shares
The Naked Trader's Guide to Spread Betting: How to make money from shares in up or down markets by Robbie Burns (Paperback, 2010)
Trade Like a Shark: The Naked Trader on How to Eat and Not Get Eaten in the Stock Market by Robbie Burns (Paperback, 2016)
The Naked Trader: How Anyone Can Make Money Trading Shares by Robbie Burns (Paperback, 2007)
The Naked Trader: How Anyone Can Make Money Trading Shares by Robbie Burns (Paperback, 2005)
0857191705
9780857191700
109260692
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Arrived quickley good condition have not read all of it but so far really enjoying it
by coan200509 Aug, 2018
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by bha_abr_szt9vx02 Nov, 2016
Very illuminating view of stocks and shares trading
Full of interesting insights into how to avoid the pitfalls of buying and selling shares and with numerous useful tips ,guidelines,and examples.


text:
101 Poems for Teachers by Annette Breaux | NOOK Book (eBook) | Barnes & Noble®
9781317924883
book by bo utas
A Persian Sufi Poem: Vocabulary and Terminology: Concordance,
This book, first published in 1978, treats methods of describing the total and special vocabularies ...
This book, first published in 1978, treats methods of describing the total and special vocabularies of a given text and demonstrates a procedure of description of the vocabulary of the Sufi Mathnavi poem ... composed in the middle of the ...
While most critical writing on Jonson concentrates on the plays, poems or masques seen in isolation, this title, first published in 1981, ranges across the genres to explore Jonson’s vision as a whole. The author points to the inner connections ...
Blake: The Complete Poems / Edition 3
Blake is undoubtedly one of the greatest lyricists in English poetry, yet his work is ...
Blake is undoubtedly one of the greatest lyricists in English poetry, yet his work is often complex and obscure. Many readers will be unfamiliar with the various political, social, religious, artistic, academic and literary issues that dominated Blake’s time. Alongside ...
Was the country really united in the face of the common enemy? Did people actually ...
Was the country really united in the face of the common enemy? Did people actually put the community’s needs before their own? Or were such ideas simply a series of myths created at the time and nurtured ever since. The ...

value: This website is an American bookseller. It is a Fortune 1000 company and the bookseller with the largest number of retail outlets in the United States.


text:
6,948858103
21.7k43458
85511635
3,2641836
How to redirect from a controller using a named URL mapping?
How to add multiple array values in Grails

value: This website is a question and answer website for professional and enthusiast programmers. It is the flagship site of the Stack Exchange Network, created in 2008 by Jeff Atwood and Joel Spolsky.


text:
Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway. - PubMed - NCBI
1 selected item: 20651232
Devi S1, Kuligowski MP, Kwan RY, Westein E, Jackson SP, Kitching AR, Hickey MJ.
Centre for Inflammatory Diseases, Monash University, Department of Medicine, Clayton, Victoria, Australia.
Recruitment of leukocytes to glomeruli is fundamental to the pathogenesis of many forms of glomerulonephritis. In a model of glomerulonephritis induced by in situ immune complex deposition, we previously observed that, in addition to leukocytes, platelets accumulate in glomerular capillaries, where they contribute to leukocyte recruitment. However, the mechanisms of platelet recruitment and the role of platelet-expressed P-selectin in leukocyte recruitment require further investigation. We used intravital microscopy to examine the mechanisms of platelet and leukocyte recruitment to glomeruli of mice following administration of an antibody against the glomerular basement membrane (anti-GBM antibody). Platelet recruitment was initiated within five minutes of administration of anti-GBM antibody. This was unaltered by inhibition of platelet GPIbalpha but was prevented by the absence of platelet GPVI. Fibrinogen was deposited in glomerular capillaries via a partially intercellular adhesion molecule 1 (ICAM-1)-dependent mechanism, and inhibition of alpha(IIb)beta(3), fibrinogen and ICAM-1 inhibited platelet recruitment. Notably, neutrophil depletion also reduced platelet accumulation, indicating a cooperative interaction underlying recruitment of platelets and neutrophils. Finally, using bone marrow chimeras to restrict expression of P-selectin to platelets or endothelial cells, platelet but not endothelial P-selectin was required for glomerular leukocyte recruitment. Together these data indicate that platelet recruitment in this model is dependent on the combined actions of GPVI and the alpha(IIb)beta(3)/fibrinogen/ICAM-1 pathway and that platelet P-selectin is crucial for subsequent leukocyte recruitment.
PMC2928948
10.2353/ajpath.2010.091143
Platelet accumulation in the glomerular microvasculature, as assessed using intravital microscopy. A: Glomerular accumulation of platelets was assessed via renal intravital microscopy, following i.v. infusion of 2 × 108 CFSE-labeled platelets. After an initial recording of platelet accumulation, mice were treated with anti-GBM antibody or NSG (20 mg, i.v., n = 6 per group), and platelet adhesion assessed at various time points over the ensuing 60 minutes. Data are shown as mean ± SEM. *P < 0.05 versus NSG-treated groups for each corresponding time point. B and C: Captured images of the renal microvasculature in an NSG-treated animal (B), and following anti-GBM antibody administration (C). Adherent platelets (arrows) are visible in the anti-GBM antibody-treated animal.
Platelet Recruitment to the Inflamed Glomerulus Occurs via an αIIbβ3/GPVI-Dependent Pathway
Am J Pathol. 2010 Sep;177(3):1131-1142.
Roles of GPIbα and GPVI in anti-GBM antibody-induced glomerular platelet interactions. A: The role of GPIbα was assessed by comparing glomerular platelet adhesion in mice treated with anti-GBM antibody alone (n = 6) or with the GPIbα inhibitor, alboaggregin-B (280 μg/kg, i.v., n = 3). B: The role of GPVI was determined by comparison of recruitment of platelets from FcRγ chain−/− mice, which lack GPVI, with that of wild-type platelets. Platelets were isolated from either wild-type (n = 6) or FcRγ chain−/− mice (n = 6), and anti-GBM antibody-induced glomerular platelet adhesion assessed as for previous experiments. Data are shown as mean ± SEM. *P < 0.05 versus anti-GBM antibody-treated mice with wild-type platelets.
Anti-GBM antibody alters the morphology of the glomerular endothelium within ten minutes. The structure of the glomerular endothelium was assessed using transmission electron microscopy. A: Glomerular capillary of a mouse shortly after receiving NSG, showing the typical discontinuous morphology of the glomerular endothelium (arrows) lining the capillary. B: Glomerular capillary of a mouse ten minutes after receiving anti-GBM antibody. The endothelial structure is markedly altered, with numerous protrusions into the vascular lumen (arrowheads). Scale bar = 2 μm.
Inhibition of αIIbβ3 reduces anti-GBM antibody-induced glomerular platelet recruitment within glomeruli via an effect on stable adhesion. A: To assess the role of platelet αIIbβ3 in glomerular platelet recruitment, mice were pretreated with the αIIbβ3 inhibitor, GPI562 (4 mg/kg, i.v., n = 6) before assessment of anti-GBM antibody-induced platelet recruitment. Data were compared with that of mice treated with anti-GBM antibody alone (n = 6). Data are shown as mean ± SEM. *P < 0.05 versus anti-GBM antibody-treated group for each time point. B: Assessment of the contribution of platelet GPVI and αIIbβ3 to platelet tethering (primary adhesion) within the inflamed glomerulus. Transient (>10s) interactions of CFSE-labeled platelets with the glomerulus (tethering) were quantified in mice treated with anti-GBM antibody alone, or in mice that received anti-GBM antibody and GPVI-deficient platelets, or anti-GBM antibody plus GPI562, 25 and 35 minutes after anti-GBM antibody administration (n = 6 for all groups). Data are shown as mean ± SEM. *P < 0.05 versus anti-GBM antibody alone group.
In vivo assessment of fibrinogen accumulation in inflamed glomeruli. To determine whether anti-GBM antibody induces fibrinogen accumulation in glomerular capillaries, mice were examined via intravital microscopy following administration of Alexa Fluor 488-conjugated fibrinogen (17 mg/kg, i.v.) 30 minutes before treatment with either NSG or anti-GBM antibody. In NSG-treated mice, no glomerular fibrinogen deposition is observed. In contrast, in anti-GBM antibody-treated mice, fibrinogen deposition (arrows) becomes apparent after 30 minutes and is further increased by 60 minutes. Images are representative examples of four (NSG) or five (anti-GBM antibody) experiments.
Endogenous fibrinogen accumulates within the glomerulus in response to anti-GBM antibody and promotes platelet adhesion. A–D: Role of ICAM-1 in fibrinogen accumulation. Mice were treated with either NSG, anti-GBM antibody (20 mg, i.v.), or anti-GBM antibody following pretreatment with a mAb against ICAM-1, and the kidneys were removed after 1 hour. Kidney sections were stained for fibrinogen using FITC-conjugated anti-mouse fibrinogen antibody. Minimal glomerular fibrinogen deposition was observed in NSG-treated mice (A), whereas extensive deposits of fibrinogen were detectable in glomeruli of anti-GBM antibody-treated mice (B). In mice treated with anti-ICAM-1 (C), the intensity of fibrinogen staining was reduced relative to mice treated with anti-GBM antibody alone. D: Mean intensity of glomerular fibrinogen staining in mice treated with NSG (n = 6), anti-GBM antibody alone (n = 9), and anti-GBM antibody plus anti-ICAM-1 (n = 9), as assessed using image analysis. Data were assessed in >25 glomeruli per animal and are shown as mean ± SEM. **P < 0.0001 versus NSG-treated mice. ***P < 0.01 versus mice treated with anti-GBM antibody alone. E: To assess the role of fibrinogen in glomerular platelet recruitment, mice were pretreated with a function-blocking antibody against mouse fibrinogen (n = 6) before assessment of anti-GBM antibody-induced platelet recruitment. Data were compared with that of mice treated with anti-GBM antibody alone (n = 6). Data are shown as mean ± SEM. *P < 0.05 versus anti-GBM antibody-treated group for the time points indicated.
Inhibition of ICAM-1 and neutrophil depletion reduce anti-GBM antibody-induced glomerular platelet recruitment within glomeruli. A: To assess the role of ICAM-1 in glomerular platelet adhesion, mice were pretreated with a mAb against ICAM-1 (200 μg, i.v., n = 7) or isotype control mAb (n = 7) and anti-GBM antibody-induced platelet recruitment assessed as performed previously. Data are shown as mean ± SEM. *P < 0.05 versus isotype control group for each time point. B: To determine the effect of neutrophil depletion on glomerular platelet recruitment, mice were pretreated with RB6-8C5 (150 μg, i.p., n = 6) 24 hours before assessment of anti-GBM antibody-induced platelet recruitment. Data were compared with that of mice treated with anti-GBM antibody alone (n = 6). Data are shown as mean ± SEM. *P < 0.05 versus anti-GBM antibody-treated group for each time point.
Platelet-derived P-selectin contributes to leukocyte recruitment in the inflamed glomerulus. Intravital microscopy was used to assess anti-GBM antibody-induced glomerular leukocyte recruitment in P-selectin chimeric mice. The following mice were examined: wild-type mice reconstituted with wild-type bone marrow (wild-type into wild-type, n = 6), P-selectin−/− mice reconstituted with wild-type bone marrow (wild-type into P-sel−/−, n = 7), wild-type mice reconstituted with P-selectin−/− bone marrow (P-sel−/− into wild-type, n = 7), and P-selectin−/− mice reconstituted with P-selectin−/− bone marrow (P-sel−/− into P-sel−/−, n = 6). Data show glomerular leukocyte adhesion assessed two hours after administration of anti-GBM antibody (20 mg, i.v.). Data are shown as mean ± SEM. *P < 0.05 versus wild-type into wild-type and wild-type into P-sel−/−.
ADP inhibition via apyrase reduces glomerular accumulation of leukocytes but not platelets. A: Effect of apyrase treatment on anti-GBM antibody-induced glomerular platelet accumulation. Mice were treated with the ADP-metabolizing enzyme apyrase (0.2 U/g, i.v., n = 6) before administration of anti-GBM antibody, and glomerular platelet adhesion was assessed using intravital microscopy as for previous experiments. Data were compared with mice treated with anti-GBM antibody alone (n = 6). Data are shown as mean ± SEM. B: Effect of apyrase treatment on anti-GBM antibody-induced glomerular leukocyte accumulation. Mice were treated with NSG, anti-GBM antibody alone, or anti-GBM antibody and apyrase (as above), and glomerular leukocyte adhesion was assessed using intravital microscopy. Data show leukocyte adhesion two hours after administration of either NSG, anti-GBM antibody alone, or anti-GBM antibody in apyrase-pretreated mice (n = 6 per group). Data are shown as mean ± SEM. **P < 0.05 versus NSG-treated mice, and *P < 0.05 versus anti-GBM antibody-treated mice.
Model of anti-GBM antibody-induced recruitment of platelets and neutrophils. Diagram of hypothesized mechanism by which platelets and neutrophils are recruited to the glomerulus in response to anti-GBM antibody. A: Following deposition of anti-GBM antibody, platelets adhere to the glomerular capillary in a GPVI-dependent fashion. This leads to activation of platelet αIIbβ3 integrin. Fibrinogen is also deposited in the glomerular microvasculature in a partially ICAM-1-dependent fashion. Platelet adhesion is then stabilized via an αIIbβ3-dependent interaction, using fibrinogen as one potential ligand. Platelets are further activated by an apyrase sensitive mechanism, presumably ADP, resulting in platelet P-selectin up-regulation. B: Neutrophils subsequently adhere in glomerular capillaries via interaction with platelet P-selectin, and additionally via β2 integrin-dependent adhesion, potentially with ICAM-1. Additional platelets accumulate in the glomerular microvasculature via interaction with adherent neutrophils.

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text:
$7,000 per migrant can’t persuade Italy to take in those who get stranded at sea - The Washington Post
$7,000 per migrant can’t persuade Italy to take in those who get stranded at sea
Migrants intercepted aboard dinghies off the coast in the Mediterranean Sea are seen on a rescue boat after arriving July 18 at the port of Malag in southern Spain. (Jon Nazca/Reuters)
After a days-long standoff, Spain finally acquiesced and opened its doors, redirecting the boat to Valencia. On Twitter, Italian Interior Minister Matteo Salvini, an immigration hard-liner who says Italy has carried too much of the burden of the Europe's migration crisis, called the redirection of the boat a “victory.”
“This was a first important signal that Italy cannot go on alone supporting this huge weight,” Salvini said at a news conference after Spain agreed to take in the ship.
As The Washington Post's Chico Harlan reported in June, that tense episode shed light on how Italy's new populist, anti-immigration government could influence the years-long debate in Europe over which countries should take in migrants and how their asylum claims should be handled. According to European rules, refugees applying for asylum must do so in the country where they are first registered — a situation that does not suit front-line countries such as Italy and Greece, where many migrants first land.
On Tuesday, as part of a regional effort to deal with migrants, the European Commission offered to pay countries up to $7,000 per migrant they take in, hoping to persuade more countries to accept migrants rather than simply turn them away. Brussels also offered to pay for the hundreds of staff members needed to manage centers where migrants and asylum seekers could be processed to avoid having them travel through Europe to secondary destinations.
“We aren’t asking for charity handouts. Every asylum-seeker costs the Italian taxpayer between 40,000 and 50,000 euros,” Salvini said after the offer was announced. “Brussels, they can keep their charity for themselves.”
Jeff Rathke, a senior fellow at the Center for Strategic and International Studies' Europe program, said that “it's not really about the money for the Italians.”
“It's about their desire along with a few other like-minded E.U. member states to shift the debate and shift the paradigm of how Europe is dealing with migration,” Rathke said. “I think it's unlikely that a particular level of compensation is going to change the approach or perspective of this Italian government.”
“We don’t want money,” he told reporters. “We want dignity.”

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The Book of the Path -[Spoilers All] : KingkillerChronicle
u/CamFush
The Book of the Path -[Spoilers All]
Something which might have been obvious to everyone else, but I only picked up on in my second read through, is that the name The Book of the Path is probably related to Trapis' story:
"Then Tehlu drew a line in the dirt of the road so that it lay between himself and all those who had come. 'This road is like the meandering course of a life. There are two paths to take, side by side. Each of you are already travelling that side. You must choose. Stay on your path, or cross to mine.'"
Just wondering if it had been discussed before.
Sword5 points · 2 years ago
You are no longer Rengen, now you are Wereth, the forger of the path.”
The name is similar to Rethe, the one who wrote the 99 stories of the Lathantha.
I think that it's the main story of the book of path, the story of tehlu chasing encantis before trapping him beneath the Iron wheel. I also am pretty sure that most of not all of the demons in that story are the fae.
Devi's Advocate1 point · 2 years ago
There's a 2012 [interview] (http://www.tor.com/2012/05/17/rothfuss-reread-pat-answers-the-admissions-questions/) on the TOR site in which Pat answers fan questions.
Somewhere near the bottom, Pat confirms a theory that the "Mender Heresies" (the story about Menda) caused a schism of the Tehlin church, which later died out. He also confirms that Trapis is a follower of this dead branch of Tehlinism.
So yes Trapis' Menda story is related to the book of the path. However, the Tehlin Church would argue that the Menda story (or some part of it) is false and heretical.
The Tehlins supplant Aleph with Tehlu.


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View all 2,231 Verified Reviews
Learn more.Expedia Verified ReviewsAll reviews are verified by Expedia, to ensure a traveler has booked with us and stayed at the property. When we send an email with a link to submit a hotel review, we may include a coupon for savings on a future trip, to encourage review submission. We publish both positive or negative reviews, when they meet our content guidelines. 5 out of 5	by Elizabeth from Walnut Creek CA Posted Feb 22, 2017 Stayed recently four nights for medical symposium hosted by Omni. Hotel location right at Gaslamp Quarter across the street from San Diego convention center. Omni room accommodations, catering, accommodations, restaurants fabulous. Room immaculate, well appointed, amenities restocked daily, bedding luxurious and comfortable, spacious Minor complaints: Monster Jam event on Feb 19 was disruptive and noisy until 11 pm, but they generously provided multiple sets of earplugs. Glass shelves in bathroom mildly dusty, but tub, sink, toilet, fixtures immaculate. I would gladly return for future symposia and also for rest & relaxation!
No, this review was not helpful.	No Love this hotel. It's located right near gaslamp!
4 out of 5	by lana Love this hotel. It's located right near gaslamp!
Was this review helpful to you? For review titled Love this hotel. It's located right near gaslamp!:Yes, this review was helpful Yes 0
For review titled Love this hotel. It's located right near gaslamp!:	No Great views but too much noise
2 out of 5	by Vickie from Seattle Great views but too much noise
Was this review helpful to you? For review titled Great views but too much noise:Yes, this review was helpful Yes 0
For review titled Great views but too much noise:	No Nice hotel in heart of downtown.
4 out of 5	by Will Nice hotel in heart of downtown.
Posted Feb 18, 2017 I chose this hotel because of its proximity to downtown and because it was more affordable than the others. The staff was excellent and I had no problems with the room, except the fact the room did not come with a refrigerator. I improvised by filing the sink with ice but the hotel shouldn't restrain you from bringing your own drinks into the hotel. That's why I am giving the hotel 4 stars vs 5. Was this review helpful to you? For review titled Nice hotel in heart of downtown.:Yes, this review was helpful Yes 0
For review titled Nice hotel in heart of downtown.:	No Lovely hotel near the convention center and Petco
5 out of 5	by Nancy from New Hampshire Lovely hotel near the convention center and Petco
Posted Feb 18, 2017 Pros: Location, facilities, staff
Cons: A female concierge was not as friendly or knowledgeable as I would have expected, Would like a small convenience store in lobby, Location: Right at the gate to the Gaslight district. Walk across the street to the convention center or Petco stadium. The staff is very helpful, They hotel is well kept, they had umbrellas to borrow for a rainy day. Love the rooftop pool and hottub . I love to stay here. Was this review helpful to you? For review titled Lovely hotel near the convention center and Petco:Yes, this review was helpful Yes 0
For review titled Lovely hotel near the convention center and Petco:	No Amazing hotel!
Posted Feb 17, 2017 Location: Located downtown, right next to Petco Park and Gaslamp. Easy to get everywhere.
5-star service we were very impressed. We look forward to going back to San Diego and staying here again!
For review titled Amazing hotel!:	No Good location
Posted Feb 16, 2017 We stay in Omni's all over the place. I expected a little nicer quality of bed linens. But it was nice enough.
For review titled Good location:	No Perfect weekend 5 out of 5	by A verified traveler Perfect weekend Posted Feb 13, 2017 Pros: Staff, room, location Location: Everything is within walking distance Staff upgraded room on arrival with gift for my 50th birthday. Wonderful hotel in perfect Gaslamp location Was this review helpful to you? For review titled Perfect weekend :Yes, this review was helpful Yes 0
For review titled Perfect weekend :	No Friends 50th!
5 out of 5	by Holly from P Friends 50th!
Posted Feb 12, 2017 I flew into San Diego to celebrate my best friends birthday and the Omni was the perfect location. The staff was very welcoming and the room was exceptional. The water pressure was impressive and the bed was dreamy. I will definitely be a returning guest. Was this review helpful to you? For review titled Friends 50th!:Yes, this review was helpful Yes 0
For review titled Friends 50th!:	No Great location near the SD Convention Center
5 out of 5	by Paul from Bakersfield, CA Great location near the SD Convention Center
Posted Feb 8, 2017 Pros: This is a modern hotel in a perfect location close to the SD Convention Center and The Gaslight District.
Hotel staff was great, from the parking attendants to the desk staff. The only negative I can give this hotel is the lack of soundproofing between rooms. I don't know if the entire hotel is like that since we were on the top floor, but we could hear people in adjoining rooms having a normal conversation. I understand that making rooms completely soundproof is impossible, but the walls seem to be extremely thin. We were kept up for about an hour starting around 2:30 a.m. as the group of women/girls in the next room decided to bring their party back to hotel once the bars closed. Eventually, hotel staff came and everybody got back to sleep.
Was this review helpful to you? For review titled Great location near the SD Convention Center:Yes, this review was helpful Yes 0
For review titled Great location near the SD Convention Center:	No See text reviews


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