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1089 Verified Hotel Reviews of Hôtel Amirauté | Booking.com
Reviews of Hôtel Amirauté
Reviews of Hôtel Amirauté 3 stars
4, rue Adolphe Guiol, 83000 Toulon, France
#3 of 14 hotels in Toulon
Languages: All languages Arabic Catalan Croatian Czech Dutch English Finnish French German Greek Hungarian Italian Japanese Norwegian Polish Portuguese Romanian Russian Simplified Chinese Slovenian Spanish Swedish Turkish
“Driving to hotel is a disaster...”
눉Arriving by car from autoroute you follow the signs untill Boulvard Strasbourg is ok then no more indication when you turn right.thay should improve street sign when Jean Jaure'.It took us 30 min. to find the way.not acceptable.,
눇La chambre tres bien apresles dernier travaux Very central
“Great stay in lovely hotel in the centre of Toulon”
눇Good location close to the train station yet still in a nice part of town. Excellent standard of hotel with lovely room with small balcony. Good breakfasts and very friendly and helpful staff. Also convenient for the old town and the port.
눉Could have been told that rolling blinds were installed.
눇Separate toilet. Nice bright interior. Good breakfast. Separate room for use of their computer. Quiet room on 5thfloor..
“Relative cheap but basic hotel and breakfast with friendly employees in a very disappointing city”
눉The hotel is located in the centre of Toulon what is good, but what disappointed us very much was the city(centre) Toulon itself. It felt like an unsafe and dying city. On the in a city normally most busy days of the week (Friday/Saturday begin september), during the days many shops and bars and restaurants were closed and blinded stained with graffiti. Locals also could not tell us where a good restaurant was and all reacted that in the evening Toulon is not the city to be. There are a lot of restaurants in the harbour of Toulon but were all low budget restaurants with people watching football matches on big screens. The only nice bar/brasserie in the centre we found, closed when the evening started. In the Friday and Saturday evening the streets were quite empty with exception of groups of men with cans of beer in their hands being drunk. So not a city trip to repeat for us.
눇The employees were very friendly. The hotel and breakfast are very basic but at the other hand relative low priced and so in balance.
“The rooms were very spacious and very clean.”
눉The staff was quite rude at one point. They tried to charge me EUR 3 for a toothbrush kit (which you would get for free at most hotels) and then accused me of lying about purchasing one when I had just paid EUR 300 for the room! Also while the bathroom was spacious it was not very well equipped. The hair dryer was like a hand dryer and the "shampoo" was an all in one shampoo / conditioner / body wash which I'm certain was exactly the same as the hand soap by the sink. There were no other amenities in the bathroom.
눇The rooms were very spacious and very clean. The bathroom was also quite large. The property is centrally located and is less than a 5 minute walk from the main train station and from cafes, restaurants and shops.
눇The hotel was very nice, just off the main square, a 5 minutes walk from Toulon station, 10 minutes walk from the city ferries and served by plenty of buses; also close to supermarket, pharmacies, bars and restaurants. The room was good-sized and comfortable, but the best part is the service. The staff was simply and absolutely amazing!
눉As above View was a bit limited
눇The room was super,but perhaps needed a little more explanation about the view and the noise from the road Bed was huge and very comfortable Breakfast of omelet and herb tomatoes was wonderful: so was the bread and usual buffet well worth buying Free tea and coffee but none in room: very frustrating on floor 5!! Short walk to the harbour Very helpful support about visits to local area Could have more info about rugby: we arrived to find a friendly at the Mayol no help in finding tickets
“Nice hotel poor breakfast service”
눉The breakfast was from 5 to 12:00 which is really good But when we came at 11:00 there were nothing left even cuttlery when I've asked for refill we told me it's coming, but nothing or nobody came. Other than that all good
“Cheated us with higher rate than adversitied”
눉One room air conditioner was not working the other was weak, it was heatwave, so hot! And they were remodeling the hotel... and charged us 200 a night when the adversting by their hotel for 100 a night... got them to take off 20 a night and i clude breakfast. Still not enough to make up for hot sweaty nights... was tired for a few days to overcome that.
“A hotel in the central part of the city.”
눇A hotel in the central part of the city. Walking distance to harbour. Nice, clean hotel, good value for money. Breakfast is relatively poor but at the same time you can press fresh orange juice by yourself:) Parking on the street (sometimes can be difficult to find place) or you can use underground parking for 8,5 eur/day. Friendly staff at the reception.
“drinks available at all times.”
눇drinks available at all times. very nice touch. central. Walked to train station, with luggage. Could not double lock my door from inside. Did not like that. Would use it again. Breakfast good. Robert o Keeffe
눉Only one chair in double bedroom
눇Central to all attractions, close to train and bus station. Hotel in quiet area, clean with good air conditioning and WiFi.
눇Friendly welcome and we were able to drop our luggage off early having arrived by ferry early in the morning. Spacious room and excellent bathroom and shower.
“The location is very convenient to visit other places.”
눉The bathrooms are too tiny. The wifi was down most of the time.. could be due to the unusual number of computer science geeks staying in the place due to a conference.
눇The location is very convenient to visit other places. The staff are very friendly.
“The staff were great, it was my boyfriends birthday and I...”
눇The staff were great, it was my boyfriends birthday and I asked if they could put some balloons and champagne in the room. All was organized effortlessly. It was so nice that the staff went that extra mile for us.
“Great Value for what you pay for.”
눉Shower Nozel was broken, asked for it to be fixed - 5 days later, still not fixed. So showering was a challenge . The room (like a lot of hotels in France) didn't have a Fridge and the room very small.
눇Great location. Short walk from train station - Short walk to harbour and shops. Breakfast was good. Room nice and clean and just been refurbished .
“Sparse room. Clean and functional.”
눉Poor bathroom facilities e.g. no towel rail, shower head didn't stay in place in shower holder.
눇Spacious room, sparsely furnished. Comfortable bed. Clean
“Excellent hotel - 20 minutes to Stade Mayol, on foot.”
눇Very comfortable : firm mattress and linen sheets. 2 pillows each! Housekeeping was very discrete - our room was "renovated" when we returned from the breakfast room at 9:30!!
눉My only improvement would have been the facility of coffee/tea in the rooms. Other than that there was nothing
눇This hotel is outstanding. I have stayed in many many places in the south and central France and this is the best I have used. Modern clean everything was top notch. The staff spoke excellent English and we're very efficient friendly and so helpfully. Cant speak highly enough of this place. Will use again for sure
“Really spacious room and location was great”
눉The lift never worked, we got stuck in it, couldn't get into our room at night as the door wouldn't open- problem with the new door systems.
눇Really spacious room and location was great
“A very well located and perfectly comfortable hotel but lacked some character”
눉The room was comfortable but a bit sparse. It could have been decorated more interestingly, but it had a lovely view actoss the city
눇It proved perfect for what I needed - a bed for the night with my dog in a well located hotel in the centre of Toulon.
“Best bits- central location and good value”
눉The room had no pictures (unlike the photos on the website) or any other features to personalise it and this made the room seem rather bleak and impersonal.
눇The head receptionist Kelly (not sure if spelling is right) was excellent. Really helpful at all times. Great central location. Clean and modern.
“An OK location, for a quick stop over to quickly visit Toulon. Comfortable.”
눉Not easy to reach by car. The location confused our sat nav and we ended up down one way streets - parking was not straight forward but we managed - just.
눇A good breakfast with long hours that really helps. And free coffee and tea. Friendly and informative staff. BIG modern / new room and modern bathroom. Air con worked :)
“Average AC, worst wifi, give this place some more time for renovations to be completed”
눉AC was very average, bed was quite hard, hallways looked like they were undergoing renovations, wifi was one of the worst I've experienced ever! Wifi would drop every 10 or so minutes forcing you to enter your email and room number as log ins again and again. You couldn't even copy and paste your email id because that would have made things slightly easier!!!!!
눇Free coffee from a coffee machine which was one of the best things about this place.
“Good location but a sleepless night!”
눉The AC did not work properly. Unfortunately our room was very hot and we did not sleep good at all. Shower was not functional properly either.
눇Location was good, Room was big enough. Price was fair.
눉Minibar/fridge would have been handy to keep drinking water cool.
눇Comfortable recently renovated room. Good breakfast. Friendly staff. Great location in the centre of Toulon. Nice view from a room facing the city.
“Good position but Inaccurate staff”
눉The staff at was not really accurate in the information and the preparation and cleaning of the room. No information provided on breakfast, wifi and other genral staff that are normally provoded at checkin (i had to go down twice and ask for these infos). shower gel not provIded (had to ask for it). On the second day pf my stay the room was not done and cleaned properly. The room had a small balcony and only thick courtain for creating darkness, no courtain to have light and protect intimacy. Wifi working very bad and disconnecting every two minutes.
눇Central position, Very close to the station and the pedestrian area. Very good breakfast. The room big, renovated but quite impersonal, it seemed as if they forgotten the finishings of bathroom and badroom
눉There are signs the hotel is undergoing a renovation. My room was fully renovated, but I'm not certain about all the rooms. The stairs and hall were still being renovated. This was not a problem for me, and I'm certain the hotel will look fantastic once it's completed.
“Very pleasant stay. Toulon is a beautiful city & your facility helped my family enjoy it even moreu”
눉Air conditioning was not working during our stay and no fans were available.
눇Location, staff, overall very pleasant stay
“Excellent place to stay for a couple of nights before catching ferry”
눇Good breakfast, friendly staff, right in the heart of town,spacious room
“Apart from getting a burn injury the stay was great”
눉Couldn't operate the tv. The metal desk lamp was so hot i burnt my chin on it.
눇We could open the window
눉No bidet. Also cheap soap dispenser in bathroom. No real soap.
눇The building.
“Coffe and tea always at your disposal.”
• Twin Room with Courtyard View
눇Coffe and tea always at your disposal. Excellent position in the city centre.
“I recommend this hotel,nice location”
눇Verry good
눉My room didn't have a view. No water or coffee in the room
눇It's near the train station. The breakfast is varied and tasty.
눉staff - very unhelpful and gloomy - or perhaps it was too much to work during holiday period
“Brilliant weeken in rugby mad Toulon”
눇Really comfortable bed and great location
“This is beyond our expectation, decent price for a big room...”
눇This is beyond our expectation, decent price for a big room with nice balcony
“In the middle of Toulon”
눇Good location, breakfast and staff! No frills 3 stars hotel at great value.
눉Slow lift
눇Great location, great value for money and a spacious room
“Good bed, nice staff, clean”
눇Good bed, nice staff, clean
“St. Maxime”
눉Sorry that the restaurant was closed.
“Good location good service good ratio room price”
눉The guy if the staff was new and lost in his job
눇Rooms renewed
“Very spacious rooms in the heart of Toulon”
눉The internet is very slow
눇The rooms are very spacious
Tony De Sanctis
“Great location. Very clean and pleasant”
Andreea Deea B.
눇Location, cleanliness, excellent stuff
“Superb location with very friendly and professional staff...”
눇Superb location with very friendly and professional staff (comfy bed too). A great stay
눉Air con temperature couldn't be adjusted. Corridor smelt
“Night in Toul;on”
눇Good modern room,
눇Good location and very friendly staff. Provided food recommendation for getting to know Toulon a little better.
눉Accueil situation de l hotel
눇Excellent rapport qualite prix. Tres bon accueil.
“Well situated hotel with comfortable accommodation”
눇Very good room with terrace, well equipped bathroom
눇Good easy, central place to stay!
“Room not comfortable, furniture not ergonomic, not as...”
눉Room not comfortable, furniture not ergonomic, not as luxurious as i thought it would be
“It was very noisy all night long - there was a prostitute...”
눉It was very noisy all night long - there was a prostitute "working" in the room next to ours. There was a bad smell from the toilet.
“Great location, close to restaurants and ferry,”
눇Great location, close to restaurants and ferry,
Mohamed Alsaad
“the Wi-Fi service was so bad .”
눉the Wi-Fi service was so bad .. it kept get lost and disconnected
Jan Miksatko
눇Nice rooms, with balcony, lift in the building, very helpful and friendly staff.
“Very comfortable bed, beautiful bathroom”
눇Very comfortable bed, beautiful bathroom
눇Everything was perde
“Rugby trip to toulon”
눇It was very relaxing hotel . Quite room
“I would 100% stay again. Simple. Very clean. Value for money. 👍”
눇The room was like having your own little apartment. It was lovely
“Good Location for Port”
눉Request to repair broken plumbing in the morning was ignored until made again later in the evening
눉Room could have been a little cleaner
“Location, clean, quiet, free hot drinks/ water 24/7.”
눉Room was small, no view, air con didn't work.
눇Location, clean, quiet, free hot drinks/ water 24/7.
눉Limited breakfast choice
눇Very good. Central location
“fantastic hotel in a great location with ease to get to the port and the rugby ground”
눉could have done with tea and coffee and a kettle in the room
눇room very smart and to a high standard and the extras we asked for were provided
“Great hotel especially if you are catching the Ferry.”
눉AS the hotel was excellent value for money I could not better it for the price.
눇Tea and coffee available ad lib at any time. Good location for ferry.
“Central location, Hotel is in the process of redecoration...”
눇Central location, Hotel is in the process of redecoration but this didn't affect our stay
“Great location and staff very kind.”
눇Size and quality of room
“helpful staff, delicious breakfasts and clean rooms”
눉bigger lift
눇helpful staff, delicious breakfasts and clean rooms
“Location, spatious room”
눉Breakfast poor and quite expensive
눇Location, spatious room
Aikaterini-flora
“Nice air-conditioning.”
눉The toilet was separated from the bathroom. The 10euros for the offering breakfast are too expensive.
눇Nice air-conditioning. Friendly staff.
“Good rooms in the center of Toulon.”
눇The rooms were very nice, the view was awesome, beds were comfortable, breakfast was delicious.
Browse Hôtel Amirauté traveller photo gallery
Iddesleigh, UK
Pousada Casa Templária
517997|1,535877,515707,533207,533337,515737,515727,539147,500767,537627,537537|1,508397,515177,520137,533377,517997,418135,520017,518987,515717,537537|2,537537,515767,485817,515777,515757,535677

value: This website is a Dutch online travel agency for lodging reservations & other travel products, and a subsidiary of Booking Holdings. It is headquartered in Amsterdam.The website has over 28 million listings.


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Marta in Decatur, GA with Reviews - YP.com
Marta in Decatur, GA
3. Marta Kensington Station
4. MARTA Bus Maintenance Facility
5. Heilbrun, Marta Elise, MD
6. Bator, Marta Z, MD
7. Marta Corp
9. Marta Georgia State Station
11. Marta Georgia State Station
170 Piedmont Ave SEAtlanta, GA 30303
12. King Memorial MARTA Station
13. Marta Visitors Transcard Distribution
14. Marta Employee Club
15. Botanica Santa Marta Y Hermandad Crusibel - CLOSED
16. Marta Perry Bus Facility
(404) 549-8967
17. Marta East Point
19. Marta Hamilton E Holmes STN
21. Marta Field Office
3271 Hamilton Blvd SWAtlanta, GA 30354
(470) 355-3535
25. Marta-Maintenance
29. Gasca Marta
4042 Singletree PlNorcross, GA 30093
30. Dr. Marta Maria Trujillo, DC
2800 Peachtree Industrial Blvd Ste FDuluth, GA 30097
Related Articlesfor Martamore related articles »
Meh. Second time there...menu is diverse but not much appeals to me. Had pasta with lamb Ragu that was good but not worth ~$25. Stuffed dates for an app were fine but not inspiring. Net - it's not bad but not worth the $$$.

type: global

value: This website is a United States-based web site operated by YP Holdings that provides listings for local businesses. In 2013 it was re-branded as YP.com or simply "YP".


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Amazon sells children's clothes emblazoned with 'enjoy cocaine' | Daily Mail Online
Children's clothes emblazoned with 'enjoy cocaine' were being sold on Amazon
Shopper was outraged when she discovered the range of bibs and babygrows
Her Facebook post was branded 'shocking' by similarly horrified parents
Amazon has since removed the offensive products from its online marketplace
Published: 08:02 EDT, 16 April 2018 | Updated: 12:55 EDT, 16 April 2018
The offensive range of bibs, t-shirts and babygrows was being sold by an independent retailer, believed to be based in Estonia.
The design of the garments imitates the distinctive 'Enjoy Coke' logo used by Coca-Cola, replicating the colour and font.
However the solid white curved line below the text has been replaced with a white 'powder' version.
The offensive range of bibs, t-shirts and babygrows was being sold by an independent retailer, believed to be based in Estonia
Customer Stefanie Smith was left outraged when she discovered the clothes while browsing the website yesterday. She shared her finding on the Amazon UK Facebook page
Customer Stefanie Smith was left outraged when she discovered the clothes while browsing the website yesterday.
She shared a screenshot of one baby bib design on the Amazon UK Facebook page with the caption: 'Admittedly, yes I was looking for a Libertines T-shirt but what the actual hell is this? WTF.'
Feeling grey? Queen Letizia of Spain looks chic in an... Revealed: How to buy as much ice cream as you want for the... Harry's pride: Prince gushes about 'the woman I'm about to... 'There weren't rivers of blood, there were rivers of LOVE':...
Kelly Pearson responded: 'I'm shocked? Have you emailed them a strongly-worded complaint?'
The products, which are all advertised using images of child models, were later removed from the online marketplace by Amazon.
Parody: The products imitate the distinctive 'Enjoy Coke' logo used by Coca-Cola
The products, which feature a line of white powder, are advertised using child models, above
Earlier this year Amazon were slated after it emerged third party sellers were advertising Chinese fancy dress with pictures of white children making 'slant-eyed' gestures.
The costumes, described as 'Chinese boy fancy dress costume' and priced between £21.86 and £22.02, were being sold with the offensive photograph on Amazon by Atosa and Fyasa.
A spokesman for Amazon said: 'All Marketplace sellers must follow our selling guidelines and those who don’t will be subject to action including potential removal of their account. The products in question are no longer available.'
Amazon sells children's clothes emblazoned with 'enjoy cocaine'

value: This website is the website of the Daily Mail, a newspaper in the United Kingdom, and of its sister paper The Mail on Sunday. MailOnline is a division of dmg media, which is owned by Daily Mail and General Trust plc.


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jsf 2 - Slowness with with multiple ui:includes - Stack Overflow
2 We have a page in which the main content area is controlled by ui:includes, basically we have a h:panelGroup with a rendered condition and the ui:include inside of it. Like this:
<h:panelGroup rendered="#{bean.page.id eq bean.page1ID}">
<ui:include src="page.xhtml"/>
We have about 10 of those. Each page is pretty complex, having a few beans of their own. The reason we are doing the rendered trick instead of a dynamic ui:include is because there is a bug in which the @ViewScoped beans used outside the ui:include get re-instantiated inside the ui:include thus causing all sorts of issues.
Any time we perform some action it takes several seconds (7 to 15 usually) for the action to be performed. For example when we change the bean.page property and request a render. Even when we do something simple like saving a value which doesn't involve hardly anything else it is really slow. If I remove all the h:panelGroups and ui:includes except for one then the site is really fast (1 to 2 second response). As far as I can tell all the pages in the ui:includes and the beans they use are getting instantiated. What can we do to speed this up? we are using mojarra 2.1.13 on resin 4.0.32 and primefaces 3.5. Thanks.
jsf-2 primefaces mojarra share|improve this question asked Apr 11 at 15:20
I suggest you to use custom facelet tags instead of <ui:include> ones. Including whole pages with JSF logic can carry you problems since they're included when page is built, and not when it's rendered. Look at the problem I experienced with a @ViewScoped bean.
I had that same problem which is why I went with the h:panelGroup and rendered instead of having a dynamic ui:include. I'll have to look into the custom facelet tag.
Do you have any custom context parameters? Wrong values there can significantly influence the performance.
You could try to disable the facelets refresh in your web.xml:
Setting this value to -1 disables the internal check for view declaration changes. This means that you cannot reload your xhtml pages without a redeploy but it also means higher performance.
Alternatively, you could also try to set the project stage to Production (this should include the other parameter). This disables lots of additional checks and stuff for development:
Those two settings should always be used in a productive environment.
share|improve this answer answered Apr 27 at 7:39
Not the answer you're looking for?	Browse other questions tagged jsf-2 primefaces mojarra or ask your own question.	tagged

value: This website is a question and answer website for professional and enthusiast programmers. It is the flagship site of the Stack Exchange Network, created in 2008 by Jeff Atwood and Joel Spolsky.


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Quasi-periodic - definition of quasi-periodic by The Free Dictionary
https://www.thefreedictionary.com/quasi-periodic
Dictionary, Encyclopedia and Thesaurus - The Free Dictionary 11,801,177,945 visitors served
1. (Geological Science) almost periodic
2. (Mathematics) maths (of a function) having an increase in functional value based on the increase of the variable
3. (General Physics) physics (of a motion) having two periods without a common duration
4. (Minerals) crystallog maths having an irregularly occurring pattern
5. (Mathematics) crystallog maths having an irregularly occurring pattern
On Saturn, it's known as Quasi-Periodic Oscillation (QPO) and Quasi-Quadrennial Oscillation (QQO) on Jupiter.
Cong, Liu, and Yuan prove the long-time stability of KAM tori (thus quasi-periodic solutions) of a nonlinear Schr|dinger equation subject to Dirichlet boundary conditions u(t,0) = u(t,pi) where one element in the equation is a real Fourier multiplier.
Stability of KAM Tori for Nonlinear Schr/dinger Equation
In 2014, Dheeraj Pasham (NASA Goddard) and colleagues weighed a potential IMBH using quasi-periodic oscillations (QPOs), cyclic blips in a black hole's X-ray signal that astronomers suspect are related to the object's mass.
The above bifurcation diagrams show that breathing crack plate has complex nonlinear phenomenon: quasi-periodic motion, bifurcation motion, and chaotic motion.
In a dynamic region [SIGMA] which contains n x n cells, the whole domain may consist of the periodic, quasi-periodic, or chaotic state due to the analytic solution.
Relying on my recent results on quantitative stochastic homogenization, I have made a sharp numerical analysis of these methods, and introduced more efficient variants, so that the three academic examples of periodic, quasi-periodic, and random stationary diffusion coefficients can be dealt with efficiently.
QUANTHOM: Quantitative methods in stochastic homogenization
An efficient algorithm for automatic peak detection in noisy periodic and quasi-periodic signals, Algorithms 5(4): 588-603.
CAP is a quasi-periodic EEG activity characterized by cyclic sequences of cerebral activation (phase A; about 8-15 seconds) followed by periods of deactivation (phase B; about 15-20 seconds) [5-7].
Twenty years after the discovery of neutron stars, quasi-periodic oscillations (QPOs) of X-rays were observed first from white dwarfs and then from neutron stars [13-14].
Beyond these bounds the laser output is subjected to various irregular oscillations, which extend from regular pulsing over quasi-periodic pulsing to chaotic pulsing, where chaotic pulses have both chaotic peak intensities and chaotic pulse intervals.
the quasi-periodic motion of Earth's axis of rotation in space, especially at annual and semi-annual frequencies.
Rezig, "A broad omnidirectional reflection band obtained from deformed Fibonacci quasi-periodic one dimensional photonic crystals," J.

value: This website is an American online dictionary and encyclopedia that aggregates information from various sources.


text:
Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis. - PubMed - NCBI
Search: 25694553
Search: 25694553[uid]
Heinecke KA1, Luoma A2, d'Azzo A3, Kirschner DA1, Seyfried TN4.
Department of Biology, Boston College, Chestnut Hill, MA, USA Department of Biochemistry and Molecular Biology, Committee on Immunology, University of Chicago, IL, USA.
Department of Biology, Boston College, Chestnut Hill, MA, USA seyfridt@bc.edu.
GM1-gangliosidosis is a glycosphingolipid lysosomal storage disease involving accumulation of GM1 and its asialo form (GA1) primarily in the brain. Thin-layer chromatography and X-ray diffraction were used to analyze the lipid content/composition and the myelin structure of the optic and sciatic nerves from 7- and 10-month old β-galactosidase (β-gal) +/? and β-gal -/- mice, a model of GM1gangliosidosis. Optic nerve weight was lower in the β-gal -/- mice than in unaffected β-gal +/? mice, but no difference was seen in sciatic nerve weight. The levels of GM1 and GA1 were significantly increased in both the optic nerve and sciatic nerve of the β-gal -/- mice. The content of myelin-enriched cerebrosides, sulfatides, and plasmalogen ethanolamines was significantly lower in optic nerve of β-gal -/- mice than in β-gal +/? mice; however, cholesteryl esters were enriched in the β-gal -/- mice. No major abnormalities in these lipids were detected in the sciatic nerve of the β-gal -/- mice. The abnormalities in GM1 and myelin lipids in optic nerve of β-gal -/- mice correlated with a reduction in the relative amount of myelin and periodicity in fresh nerve. By contrast, the relative amount of myelin and periodicity in the sciatic nerves from control and β-gal -/- mice were indistinguishable, suggesting minimal pathological involvement in sciatic nerve. Our results indicate that the greater neurochemical pathology observed in the optic nerve than in the sciatic nerve of β-gal -/- mice is likely due to the greater glycolipid storage in optic nerve.
X-ray diffraction; cerebrosides; gangliosides; lipids
PMC4342369
10.1177/1759091415568913
High-performance thin-layer chromatograms of neutral lipids in the optic and sciatic nerves of β-gal −/− and +/? mice. Representative samples for each age group and tissue type are presented. The amount of total lipids spotted per lane was equivalent to approximately 80 µg nerve dry weight. The plate was developed and the lipid bands visualized as described in Materials and Methods section. Std indicates 4 µg of neutral lipid standards and 2µg of GA1 standard. CE = cholesterol ester; TG = triacylglycerol; IS = internal standard (oleoyl alcohol); C = cholesterol; CM = ceramide; CBU = cerebroside upper band; CBL = cerebroside lower band; PE = phosphatidylethanolamine; PC = phosphatidylcholine; SM = sphingomyelin; LPC = lysophosphatidylcholine; SF = solvent front. The arrows indicate the presence of GA1 in the specific samples. Optic nerve contained no visible TG and sciatic nerves contained no visible CE.
Myelin Abnormalities in the Optic and Sciatic Nerves in Mice With GM1-Gangliosidosis
ASN Neuro. 2015 Jan-Feb;7(1):1759091415568913.
High-performance thin-layer chromatogram of gangliosides in the optic and sciatic nerves of β-gal −/− and +/? mice. Representative samples for each age group and tissue type are presented. Approximately 1.5 µg of ganglioside sialic acid were spotted per lane. Std, ganglioside standards for the labeled gangliosides; gangliosides GM2 and GD3 were not visualized in the nerve lipids. The plate was developed and the lipid bands visualized as described in Materials and Methods section.
High-performance thin-layer chromatogram of acidic lipids in the optic and sciatic nerves of β-gal −/− and +/? mice. Representative samples for each age group and tissue type are presented. The amount of total lipids spotted per lane was equivalent to approximately 230 µg nerve dry weight for the acidic lipids. The plate was developed and the lipid bands visualized as described in Materials and Methods section. Std, 4 µg acidic lipid standards. IS = internal standard (oleoyl alcohol); CL = cardiolipin; PA = phosphatidic acid; SFU = sulfatide upper band; SFL = sulfatide lower band; PS = phosphatidylserine; PI = phosphatidylinositol; SF = solvent front.
X-ray diffraction from optic and sciatic nerves from β-gal mice. Representative examples of data for optic (left) and sciatic (right) nerves from β-gal +/? and β-gal −/− are shown. Myelin scatter was significantly weaker in optic nerves (p < .001) and marginally weaker in sciatic nerves (p < .03) of β-gal −/− mice compared to nerves from β-gal +/? mice. The Bragg orders for the X-ray peaks are indicated by 2–5.
XRD analysis of myelin content and myelin periodicity in β-gal −/− and β-gal +/? mice. The fractional amount of scatter by compact myelin (M) compared with the relative amount of total X-ray scatter (M + B) is plotted against the myelin period, in Angstroms (Å). The mean value and standard deviations are indicated for each group of data (N = 12 nerves per group for β-gal +/?, and six nerves per group for β-gal −/−). The relative amount of myelin was significantly lower in the optic and sciatic nerves of β-gal −/− (○) mice compared to β-gal +/? (♦) mice. Myelin periodicity was significantly less in the optic nerves of β-gal −/− (○) mice than in β-gal +/? (♦) mice. The sciatic nerves of β-gal −/− (○) and β-gal +/? (♦) mice showed no significant differences in periodicity. Asterisks indicate statistical significance of p < .003, based on Student’s two-tailed unpaired t test.
Gangliosidosis, GM1/genetics*
Gangliosidosis, GM1/pathology*
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