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Computed Tomography for Imaging the Breast | Ct Scan | Medical Imaging
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Journal.pmed.1000337
J Mammary Gland Biol Neoplasia (2006) 11: 103–111 DOI 10.
1007/s10911-006-9017-1
John M. Boone & Alex L. C. Kwan & Kai Yang & George W. Burkett & Karen K. Lindfors & Thomas R. Nelson
Published online: 20 October 2006 # Springer Science + Business Media, Inc. 2006
Abstract Despite the success of screening mammography contributing to the reduction of cancer mortality, a number of other imaging techniques are being studied for breast cancer screening. In our laboratory, a dedicated breast computed tomography (CT) system has been developed and is currently undergoing patient testing. The breast CT system is capable of scanning the breast with the woman lying prone on a tabletop, with the breast in the pendant position. A 360° scan currently requires 16.6 s, and a second scanner with a 9-second scan time is nearly operational. Extensive effort was placed on computing the radiation dose to the breast under CT geometry, and the scan parameters are selected to utilize the same radiation dose levels as two-view mammography. A total of 55 women have been scanned, ten healthy volunteers in a Phase I trial, and 45 women with a high likelihood of having breast cancer in a Phase II trial. The breast CT process leads to the production of approximately three hundred 512 × 512 images for each breast. Subjective evaluation of the breast CT images reveals excellent anatomical detail, good depiction of microcalcifications, and exquisite visualization of the soft tissue components of the tumor when contrasted against adipose tissues. The use
J. M. Boone (*) : A. L. C. Kwan : K. Yang : G. W. Burkett : K. K. Lindfors Department of Radiology, UC Davis Medical Center, University of California, Davis, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USA e-mail: jmboone@ucdavis.edu J. M. Boone : K. Yang Department of Biomedical Engineering, UC Davis Medical Center, University of California, Davis, Sacramento, CA 95817, USA T. R. Nelson Department of Radiology, University of California, San Diego, La Jolla, CA 92093, USA
of iodine contrast injection dramatically enhances the visualization of tumors. While a thorough scientific investigation based upon observer performance studies is in progress, initial breast CT images do appear promising and it is likely that breast CT will play some role in breast cancer imaging. Keywords Mammography . Cancer . Computed tomography . Radiation . Technology Abbreviations CT computed tomography MTF modulation transfer function BIRADS breast imaging reporting and diagnosis system
Introduction The introduction of mammography as a screening test for mammography has led to a significant reduction in breast cancer mortality over the past two decades [1, 2]. Recent advancements in digital mammography have recently been shown to improve breast screening sensitivity for women with dense breasts [3], and these intermediate results should lead to greater reductions in mortality over the long term. Despite the apparent success of mammography (screen film and digital), most breast imaging experts agree that there is substantial room for improvement [4, 5]. With mammography, a threedimensional object (the breast) is imaged, which results in two nearly orthogonal projection images, the cranial caudal (CC) view and the medial lateral oblique (MLO) view. With projection mammography, especially in women with dense breasts, the shadow of a breast tumor can easily be hidden within the complicated background structure of the glandular
It is estimated that the average light photon undergoes 10. which occurs typically after a suspicious lesion is identified by mammography screening or when a palpable mass presents. instead of a two-dimensional projection image of the entire three-dimensional breast. However. 39]. The benefit that ultrasound imaging. most of these groups have worked with cadaver and mastectomy specimens to produce CT images of the breast. Tornai and his colleagues at Duke University are also engaged in the development of a breast CT scanner and have proposed a hybrid system capable of both computed tomography and single-photon emission computed tomography (SPECT) [40–42]. Magnetic resonance imaging (MRI) has recently been demonstrated to have superior sensitivity compared to mammography in younger. Nevertheless. and many optical techniques (e. Optical approaches to breast cancer screening are appealing due to potential cost effectiveness and the lack of ionizing radiation. it remains the most practical and cost-effective approach for breast cancer screening at the present time. ultrasound imaging as currently practiced clinically is a time intensive procedure which requires an experienced practitioner. Shaw and colleagues at MD Anderson Cancer Center have also built a working prototype scanner capable of imaging cadaver and mastectomy specimens [43]. developed a breast CT scanner in the mid 1970s . have developed a prototype breast CT scanner. Ultrasound imaging is very useful for soft tissue lesions (masses) and is routinely used to differentiate between soft tissue masses and cysts. Gisvold and his colleagues at the Mayo Clinic. and a small fraction (∼15%) of individuals do not tolerate MRI due to claustrophobia. MR is probably not a cost-effective tool for breast cancer screening in the general population. and therefore the superposition problem which detrimentally affects mammography can be overcome. MRI is significantly more expensive. MRI. and have reported a number of intriguing results comparing breast CT against mammography [38. While the demonstrated higher sensitivity of contrastenhanced MRI over mammography is encouraging. Glick and his colleagues at the University of Massachusetts. which have markedly different appearances under ultrasound. working with scientists at General Electric. no optical technique has demonstrated detection sensitivity approaching that of X-ray mammography. While mammography is imperfect. However. Optical techniques for imaging the breast are compromised by the fact that light in the optical wavelengths scatters significantly while propagating through the breast. the appearance of X-ray CT images and MRI images are similar at least subjectively. high-risk women [19–27]. While MRI technology makes use of fundamentally different physical properties of breast tissue to form the image than X-ray imaging does. Worcester. the spatial resolution of optical breast imaging modalities is typically quite low. The efforts of these groups to date have been primarily oriented toward technology development. Nevertheless. Recognizing the power of tomographic methods for potentially improving breast cancer detection. significant advancements in optical imaging techniques have occurred. and thus tumors need to be quite large to be detected. a number of investigators have pursued the development of X-ray CT techniques designed specifically for imaging the breast [28–30].000 scattering events while propagating through a typical breast. moreover. Predating all of these efforts. optical coherent tomography) have over mammography is that they are tomographic: the imaging procedure produces a number of virtual slices of the breast. The benefit of tomographic imaging procedures is that the overlying and underlying anatomical tissue can be effectively removed when viewing individual slices. then it will be apparent in the other. This requirement substantially increases the actual costs of performing ultrasound-based breast cancer screening. Furthermore. the apparent success of contrast-enhanced MRI demonstrates the added sensitivity that can be achieved by highlighting tumors using appropriate vascular targeting methods.. the rationale is that if the breast tumor is obscured in one view. By getting two nearly orthogonal views of the breast. Ning and colleagues at the University of Rochester have developed a cone-beam CT scanner [31–33] and have reported on the potential of this technology for breast imaging [34–37]. few studies have demonstrated that ultrasound imaging by itself can match the sensitivity of mammography. the image acquisition process takes much longer than mammography. Optical imaging techniques [12–18] have been explored as potential tools for breast cancer screening.g. A number of other investigators [44. as both are sensitive to differences in mass density. due to the reduced endotheliation of vessels within the tumor. a number of investigators are developing alternative imaging procedures for breast cancer screening.104 J Mammary Gland Biol Neoplasia (2006) 11: 103–111 tissues of the breast. and a number of investigators are still pursuing this appealing concept. However. There are a number of studies which seek to improve breast ultrasound imaging to make it more practical for breast cancer screening [5–11]. tumors which are superimposed with glandular anatomy in both views can be missed by even the most experienced radiologist. Consequently. 45] have also become interested in the potential of breast CT. Modern MRI breast imaging makes routine use of an injected contrast agent (gadolinium GTPA). however. The kinetics of this contrast agent are such that it tends to accumulate near many breast cancers. and thus this modality is fiscally impractical for routine breast cancer screening. Ultrasound imaging of the breast is performed routinely as part of the diagnostic breast examination.
and the technology available to these early investigators was limited in comparison to today’s Xray detectors. Thus. In addition to the moveable X-ray shutter.4 mm 640 Watt. With this geometry. the X-ray source and active detector elements need to be positioned immediately below the tabletop to insure coverage of breast tissue near the chest wall (Fig.53 mm picture element dimensions). Given these basic design constraints. the X-ray tube assembly includes a lead collimator which focuses all primary radiation onto the rectangular detector. the pendant geometry was utilized whereby the woman lies prone on a table with the breast to be imaged placed through a hole positioned at the center of the table. Computed Tomography of the Breast A breast CT (bCT) scanner was designed.194 × 0. Switzerland). Because it is essential to image all of the woman’s breast tissue in a screening examination. For a bCT system to scan only the breast. [53–56] Design and Fabrication The bCT system made use of several off-the-shelf components. Varian Medical Systems. These investigators evaluated this technology by scanning several thousand women. 1a). Image Acquisition Because the X-ray system takes a few moments to stabilize and achieve constant radiation output. For additional radiation shielding. VA). East Haven. Component X-ray tube Characteristics Focal spot: Water cooled W anode. The X-ray tube and detector components of the CT scanner are mounted on a rotating gantry. CT) and X-ray tube system (Comet. the bCT system was designed at our institution and fabricated at a local machine shop.388 × 0. images are acquired as the gantry rotates around the breast (Fig. the X-ray detector system becomes the primary barrier for radiation protection.3 mm Cu added filtration kVp range: 10–110 kVp Detector: indirect detection (Csl scintillator) thin film transistor Native pixel matrix: 2048 × 1536 Native pixel dimension: 0. the panels which surround the bCT gantry were fabricated to include an internal layer of lead. It should be noted that this early breast CT scanner produced a number of thick-slice (10 mm section thickness) images of relatively low resolution (1. positioned approximately 90 cm away. an X-ray generator (Pantak HF160. and the in-plane resolution is generally superior to breast CT. Flamatt. The technical specifications for some of these components are listed in Table 1. these panels provide the secondary radiation shielding to reduce the scattered radiation levels in the room during the scan. and a computer-controlled motor with integrated angle encoder (Kollmorgan. A thick lead shutter system was developed with two opposing solenoids which were used to open the X-ray shutter under computer control. 1b). beryllium window 0.J Mammary Gland Biol Neoplasia (2006) 11: 103–111 105 [28. characterized for image quality and radiation dose performance. there has been much interest academically and commercially in the potential of limited angle tomography for breast imaging. and it remains to be seen which technology is superior overall for breast cancer detection. X-ray tubes. computers. and reconstruction algorithms. fabricated.194 mm 2 × 2 pixel binned matrix: 1024 × 768 2 × 2 pixel size: 0. The conclusion from these early clinical trials on breast CT was that iodinated contrast agent injection was necessary in breast CT to match the sensitivity of the mammography of that era. Palo Alto. tomosynthesis may outperform breast CT for microcalcification detection. laminated to the external aluminum support. Both breast CT and tomosynthesis are tomographic X-ray techniques for breast imaging. usually referred to as “tomosynthesis” [49–52].. good image coverage towards the posterior of the breast (“chest wall”) is essential. while breast CT will likely outperform tomosynthesis for soft tissue (mass) lesion detection.388 mm Frame rate: 30 frames per second at 2 × 2 binning Torque: 13 ft–lbs continuous torque Minimum rotation speed: one RPM Detector Motor . i.53 × 1. A photograph of the first bCT prototype is shown in Fig. Radford. To accommodate this constraint. and a number of projection Table 1 Characteristics of the off-the-shelf components used in the breast CT scanner. Tomosynthesis is capable of producing thick-section images with high inplane spatial resolution. a flatpanel digital detector system (Paxscan 4030CB. 1c. max mA at 80 kVp: 8 mA 0. CA). While “breast CT” or “CT mammography” refers to true computed tomography of the breast. In addition to the floor and the 4 mm thick stainless steel table. and is currently undergoing testing in a Phase II clinical trial at our institution.e.4 × 0. Probably the most significant advantages of tomosynthesis is that it can be performed on existing digital mammography systems with relatively minor modifications. 46–48]. an X-ray shutter system was developed to switch the X-ray beam between the on and off positions.
The large area detector results in a conebeam geometry. With the current tabletop design. and the electronics supporting these devices are mounted in the stationary laboratory frame. and cables connecting stationary to moving components were routed through a commercially available chain-link system. with perhaps 10% of patients able to position themselves deep enough into the scanner for this. . must be minimized. we have achieved only marginal success in imaging up to the chest wall. horizontal arm. However. 2 in the scanning position. and together these components comprise the rotating gantry. the technology for computing radiation dose to the breast in the geometry of a dedicated breast CT scanner was not available. with the tabletop taken off.106 J Mammary Gland Biol Neoplasia (2006) 11: 103–111 a breast x-ray source detector b table-top breast x-ray tube detector c subsystems. It was felt that 17 s was a reasonable amount of time to expect a woman to hold her breath while in the prone position for a prototype scanner. a series of Figure 1 (a) The geometry of the X-ray source and detector of the breast CT scanner is illustrated. trial and error has been required in order to study which tabletop designs are better capable of imaging the entire breast. This depression allows the woman’s thoracic region to “slump” into the scan plane. It is expected that the reduction of the breast CT acquisition time from 17 to 9 s will result in far greater patient compliance and reduced motion artifacts. to reduce motion artifacts (which occur when the patient moves during the acquisition) the scan time should be reduced. To accommodate this. (b) This cross-section diagram illustrates the tabletop with pendant breast. with her right breast positioned in the pendant geometry and in the scanning position. The X-ray source and detector rotate on a moving gantry around the breast during acquisition. Consequently. a spiral chain mechanism was used to connect the stationary electronics to the rotating X-ray tube and detector Figure 2 A model is shown positioned on the breast CT scanner. Therefore. (c) An image of the breast CT scanner (first prototype) is illustrated. To acquire image data as posteriorly as possible. which must rotate freely under the table. The spiral chain-link system which connects the stationary electronics to the rotating gantry is also seen. Consequently. It is extremely important in a breast cancer screen to image all of the breast tissue at risk. such that the X-ray tube and detector can image up to the chest wall (pectoralis muscle). and from the X-ray source to the bottom of the table (shown with arrows). The X-ray tube and detector are mounted on a rotating. The detector and the X-ray tube rotate approximately 420° around the breast during an acquisition procedure (this includes gantry acceleration and deceleration in addition to the 360° scan). Consequently. At the start of this project. and this technology would not be feasible if the radiation dose levels were too high. the patient table was designed to have a 5 cm depression which spans the central region of the tabletop. the distances from the active detector to the bottom of the table. which is shown in Fig. hoses. All wires. Radiation Dose The radiation dose to the breast received during breast CT is of critical concern. 1c. and the position of the X-ray tube and detector. a second prototype breast CT scanner has been built which has an acquisition time of 9 s. A picture of a patient (model) is shown in Fig.
The image quality of both these modalities is highly dependent upon the amount of radiation striking the detector. Women with larger Figure 4 The top row of images illustrates five of the 500 “sinogram” images which are acquired by the breast CT hardware. no breast compression Figure 3 The mean glandular radiation dose to the breast is shown as a function of breast diameter. technique factors were developed which allow the radiation dose from the breast CT procedure to be virtually equal to that of standard two-view mammography [55].J Mammary Gland Biol Neoplasia (2006) 11: 103–111 107 breasts experience larger radiation doses in mammography. In the current implementation of this algorithm. With the breast CT scanner. and a cone beam CT reconstruction algorithm was written in order to reconstruct the breast CT images. with the breast hanging in the pendant position. a large number of projection images are acquired of the patient’s anatomy as the rotating gantry circumnavigates the object being scanned. Coupled with a number of other physical measurements. The mean glandular dose levels correspond to those of two-view (CC and MLO) mammography performed at our institution. which produces approximately 300 tomographic images. and Fig. is used in a CT reconstruction algorithm to produce a number of tomographic images of the object. and these are the calculated radiation doses for the breast CT examination as well. a total of five hundred 768 × 1024 projection images are acquired. for three breast compositions. Figure 4 (top panels) illustrates five of the preprocessed acquired images. The radiation levels of two view mammography are shown in Fig. The positions of the five breast CT images shown are indicated by the horizontal lines on the upper right sinogram image. and this is true with breast CT as well. The reconstructed breast CT images are illustrated in the bottom panel (five of 300 images). Exploiting knowledge gained in previous Monte Carlo simulations involving the computation of radiation dose coefficients in mammography [57]. after significant preprocessing. Monte Carlo simulations were designed specifically for the geometry of breast CT [54]. . and it requires higher levels of radiation (more dose) to penetrate larger breasts for both mammography and breast CT. 4 (bottom panels) illustrates five of the three hundred breast CT images. including the determination of the radiation dose to the breast due to two-view (cranial caudal and medial lateral oblique) mammography and the radiation output characteristics of the scanner. Patient Imaging One of the key features of breast CT is that the breast is imaged with the patient lying on the table. 3 for three different breast compositions. These data represent the input to the CT reconstruction algorithm. The optimal shape of the breast for CT scanning is cylindrical. experiments involving validated Monte Carlo studies was undertaken. three hundred 512 × 512 tomographic images are produced from the raw acquired dataset. Image Reconstruction With computed tomography. This raw dataset.
This series of images depict noncontrast-enhanced breast cancers.and underlying normal anatomical “noise”. essentially eliminating the complexity of the overlying and underlying glandular tissue which is so problematic in projection mammography imaging. demonstrating that there is intrinsic contrast between the biopsy-confirmed tumors and the surrounding (mostly adipose) tissues. Breast CT images of breast cancer are illustrated in Fig. Imaging was performed 100 s after the initiation of contrast injection. is dependent both on the effective atomic number (z) of the tissues. which requires relatively aggressive compression of the breast to achieve good image quality. (b) A ductal carcinoma in situ is illustrated. and illustrate the complex normal anatomy associated with the breast. which is also the basis of mammography screening. the digital workstation for radiologist review of the breast CT images allows extremely rapid and flexible navigation through this large CT volume dataset. X-ray contrast. 5. in comparison to mammography. One of the fundamental limitations of projection mammography is that suspicious breast lesions (cancer) can be lost in the complex background of the normal breast anatomy. allows the radiologist to pan through the three-dimensional volume dataset slice by slice. Therefore. This series of images illustrates some of the first in vivo images acquired on the breast CT scanner. The tumors Figure 6 Three breast images are shown from different patients. the identification of breast cancer using breast CT relies on anatomical changes which appear sufficiently different from the normal breast anatomy to raise suspicion. 100 ml of contrast agent was injected at the rate of 4 ml/ second through the brachial vein. (a) A spiculated lesion is seen. this examination is thought to be far more comfortable than two-view mammography. As is visible in the images shown in Fig. Contrast Agents Figure 7 illustrates several biopsy-confirmed breast tumors which have been enhanced by the intravenous injection of iodine-based contrast agent. is required nor is it desired. with the arrows illustrating the location of breast cancers which were biopsy-confirmed after the breast CT imaging. Images produced on the first prototype breast CT scanner are illustrated in Fig. While the ability to separate tissues in a series of planes (the tomographic images) does eliminate the over. this is especially true for younger women who generally have greater breast density. 6. To produce these images. . further studies (underway) are needed to evaluate the overall detection performance in breast CT. 6. just adjacent to the saline implant. with numerous microcalcifications visible. surrounded primarily by adipose tissue. it is unclear whether there would be sufficient differential contrast to identify the lesion. These images demonstrate anatomical detail not routinely seen in mammographic images. which is straddled between glandular and adipose tissue elements. The tomographic process. While print media only allow the depiction of a small number of images. as well as the electron density (electrons/cm3). While the difference in X-ray contrast between tumor and adipose tissues is high. which breast CT enables. if a tumor were completely imbedded within the normal glandular tissue of the breast.108 J Mammary Gland Biol Neoplasia (2006) 11: 103–111 Figure 5 These four breast CT images were acquired from healthy volunteers. (c) A cluster of microcalcifications is associated with this lesion.
While a greater volume of contrast agent needs to be injected for CT (compared to MRI). and is currently undergoing clinical testing in our laboratory. it is likely that this technology will have some role to play in the breast imaging clinic. Vitak B. Tabar L. Radiol Clin North Am 2000. but the vast majority of contrast reactions are minor (hives) and the documented risk is exceedingly low. It is likely that women with dense breasts would benefit by the tomographic nature of breast CT more than women with adipose breasts. one of which was not seen mammographically. Chiang CF. We are currently accruing breast CT cases (along with mammograms). . The “leaky vessel” mechanism for contrast enhancement is the same mechanism underlying the success of contrast-enhanced breast MRI. some patients are unable to undergo MRI due to claustrophobia or due to metallic implants. even if this is simply to replace stereotactic biopsy systems. The initial clinical images produced by the breast CT system demonstrate that high quality tomographic images can be produced in a dedicated pendant geometry at radiation levels identical to two-view mammography. It is estimated that breast CT on a dedicated system would be less than half the cost of an MRI-based biopsy. X-ray CT also does not suffer from spatial distortion as does MRI (very important for biopsy). the excellent detail and anatomical complexity which is seen in these images are encouraging. are well illuminated by the presence of contrast agent. which is thought to pool in the interstitial (extravascular) spaces due to the poorly constructed nascent vessels recruited by the tumor.38:625–51. under many circumstances breast CT would be more practical and cost-effective than breast MRI in a breast imaging clinic. Iodine-based X-ray contrast agent injection is associated with slightly higher risk of adverse reaction. While the clinical efficacy of breast CT awaits observer-performance evaluation. and will be performing an observerperformance study when more patient images have been acquired. et al. and regular metallic biopsy needles can be used in CT but not MRI. and could be performed in less time. which may accompany or possibly supplant screening mammography for some women. as a method for biopsy needle guidance. References 1.J Mammary Gland Biol Neoplasia (2006) 11: 103–111 109 Figure 7 Breast images which were acquired after the injection of iodinated contrast are illustrated. While it is unlikely that the use of contrast-enhanced breast CT will be practical in the screening environment. Therefore. Summary A prototype breast CT scanner has been designed. other investigators have demonstrated that contrast-enhanced breast MRI was superior in terms of sensitivity to mammography for screening women at high risk for breast cancer [58]. We are focusing on the potential of breast CT as a screening tool without contrast enhancement. Yen MF. and the California Breast Cancer Research Program (11-1B-0114). then the diagnostic mammography examination (not necessarily the screening mammography examination) may well take advantage of contrast-enhanced breast CT as an alternative to breast MRI. Chen HH. Duffy SW. Acknowledgments This work was funded in part by grants from the National Cancer Institute (CA 89260) the National Institute for Biomedical Imaging and Bioengineering (EB 002138). breast CT has several advantages. The location of the tumors (all biopsyconfirmed) is evident without the need for arrows. Thus. In addition to issues of cost. The Swedish Two-County Trial twenty years later. fabricated. If contrast-enhanced breast CT were shown to be equivalent to contrast-enhanced breast MRI. the venous placement of the catheter is the same in the two procedures and this is the most uncomfortable aspect of the examination to the patient. While it is too early to predict the ultimate diagnostic potential of the breast CT modality. The breast on the right has two lesions. A second prototype scanner is operational and will begin to be used for clinical studies shortly. Updated mortality results and new insights from long-term follow-up. an additional role of breast CT may be to serve women with a family history or who are genetically predisposed (BRCA1 and BRCA2) to breast cancer. Although breast CT obviously is associated with some exposure to ionizing radiation.
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Van Zee KJ. Elastography for breast cancer diagnosis using radiation force: system development and performance evaluation. 9.30:2915–7. 18.8:7–13. Med Phys 2004. Ning R. 28. Shipley JA. Huang SW. Caruso G. et al. Feig SA. Menna S. Part II: Application to breast cancer diagnosis.30:1694–705. Kim EN. Evaluation of tumor angiogenesis with contrast-enhanced dynamic magnetic resonance mammography.12:3018–22. Kim BS. Lancet 2005. Radiology 1979. Hendrick RE. 41. 44. Microcalcification detection using cone-beam CT mammography with a flat-panel imager. Bartella L. Ning R. Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS). J Clin Ultrasound 2003. Bowsher JE. New subtraction algorithms for evaluation of lesions on dynamic contrastenhanced MR mammography. Radiol Med (Torino) 2002. multicentric breast cancer in fatty and dense breasts using the whole-breast pathologic examination as a gold standard. Houlihan MJ. 22. Shah N. Bamber JC. Tohno E.28:235–46. Gilchrist KW. Yu G. McKinley RL. 8. Sibala JL. et al. Ramanujam N. Appl Opt 2006. Acad Radiol 2005.38:861–9.364:1111–2. Durkin A. Panizza P. Cassano E. 38. AJR Am J Roentgenol 2004. Ning R. Ning R. Cakir B. Zhou C. Computed tomographic mammography (CTM). Parham CA.7:279–85.31:800–13. Advances in breast imaging. Chen Z. Tuncbilek N. Vedantham S. 23. McKinley RL. Med Phys 2002. et al. 35.4:497–512.31:800–13. Borgen PI. Karellas A. 43. Effect of breast magnetic resonance imaging on the clinical management of breast cancer. Comput Med Imaging Graph 2005. Raptopoulos V. Med Phys 2003. Breast lesion characterization with contrast-enhanced US.14:51–6. Declining mortality from breast cancer in Yorkshire. Eur Radiol 2002. MRI in breast cancer management: potential for benefit and harm. 31. Templeton AW. Radiology 1993. Hochman M.7:700–3. Imaging in breast cancer: diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy. Simulation study of a quasi-monochromatic beam for X-ray computed mammotomography. Liu N.132:647–52. AJR Am J Roentgenol 1979. Cerussi A. 13. Chen B. 3. Samei E.19:949–63. 32. Chen B.133:1143–9. Kwag HJ. Conover D. Pera VE. IEEE Trans Med Imaging 2004. Simonetti G. Baker SP.44:583–93. Morris EA. Conover D. Cone-beam volume CT breast imaging: feasibility study.29:755–70. . Dixon AK. et al.29:1–14. Chen L. Leach MO. Hsiang D. Choe R. Noise simulation in cone beam CT imaging with parallel computing. Pieper BC. Lagalla R. Durduran T. Fausto A. Duck FA. 30. 14. Tang X. Greer KL. J Mammary Gland Biol Neoplasia (2006) 11: 103–111 24. Cirino A.31:227–38. Imaging in breast cancer: magnetic resonance imaging. Tornai MP. Baum JK. 15. Cancer Imaging 2006. 4. Forest representation of vessels in cone-beam computed tomographic angiography. Sensitivity of MRI versus mammography for detecting foci of multifocal. Glick SJ. Boggis CR. Work in progress. Pisano ED.23:696–703. Sella T. Gong X. Spatial and spectral information in optical mammography. et al. Fantini S. Jatoi I. 29.52:2011–22. Med Phys 2002. Breast volume denoising and noise characterization by 3D wavelet transform. Breast Cancer Res 2005. Chen Z. 37. Chance B.7:215–9. IEEE Trans Med Imaging 2005. Glick SJ. Kisselgoff D. Isr Med Assoc J 2005. Chang CH. IEEE Trans Med Imaging 2000.110 2. Sardanelli F. 12. 34. Image denoising based on multiscale singularity detection for cone beam CT breast imaging. Giuseppetti GM. Breast Cancer 2005. Ning R.49:2183–95. Imaging of the radiographically dense breast. NIR spectroscopic detection of breast cancer. Tchou JC. Brzymialkiewicz CN. 39. 1983–1998: extent and causes. D’Orsi CJ. McKinley RL. Easton DF. 21.9:403–8. Acad Radiol 2000. et al. Phys Med Biol 2004. Ueno E. Karellas A.24:868–77. et al. 33. Vedula AA. Pisani P. Opt Lett 2005.12:1045–53.4:471–82.6:4–6. Tang X. Comput Med Imaging Graph 2004. Ning R. Optical scanning and breast cancer. Buchanan CL. Nioka S. III. (x). 36. Conover D. 16. Kim HH. 40.29:755–70. Karakas HM. Schnall MD. Cone-beam volume CT breast imaging: feasibility study. Breast J 2003. Ning R. Tornai MP.
Moore RH. Med Phys 2002. Radiol Manage 2005. Zonderland HM. 52. et al. Beabout JW. Evaluation of X-ray scatter properties in a dedicated cone-beam breast CT scanner. Christian BT.and three dimensional radial gradient index segmentation. Shah N. Opsahl-Ong BH. Clinical evaluation of computerized tomographic mammography.52:181–5. Normalized glandular dose (DgN) coefficients for arbitrary X-ray spectra in mammography: computer-fit values of Monte Carlo derived data. Seibert JA. Boone JM. Castleberry DE. Nelson TR. N Engl J Med 2004. Med Phys 2005. 58. Stephens DH. Radiology 1997. Seibert JA. Med Phys 2004. Reese EC.32:3767–76. 111 53. Kopans DB. A comprehensive analysis of DgN (CT) coefficients for pendant-geometry cone-beam breast computed tomography. et al. Nelson TR. Med Phys 2004. Gisvold JJ. Rafferty E. Lindfors KK. Reiser I.31:226–35. 57. Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. Shah N. Computerized detection of mass lesions in digital breast tomosynthesis images using two.3:437–41. Boone JM. Rafferty EA. Digital tomosynthesis in breast imaging. 48. Boone JM. 49.351:427–37.221:657–67. Lindfors KK. . Boone JM. 55. Semin Roentgenol 1978. Niklason LT. A comparison of reconstruction algorithms for breast tomosynthesis. Karsell PR. Gisvold JJ. McLeod RA. Kwan AL. Radiology 2001.13:267–75. Mayo Clin Proc 1977. Med Phys 2005. Boetes C. Moore RH. Full-field breast tomosynthesis. Technol Cancer Res Treat 2004. Wu T. et al.32:2967–75. Brekelmans CT. Kriege M.205:399–406. Dedicated breast CT: radiation dose and image quality evaluation. Wu T. Kopans DB. Nishikawa RM. Shah N. 51. Technique factors and their relationship to radiation dose in pendant geometry breast CT.J Mammary Gland Biol Neoplasia (2006) 11: 103–111 47. Nelson TR. 56.31:2636–47. Kwan AL. Giger ML.29:869–75. Obdeijn IM. Besnard PE. 54. 50. Sheedy PF. Boone JM. Smith A. Niklason LE. Computed tomography of soft tissues and breast.27:25–31.
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Constitutional chaos : what happens when the government breaks its own laws (Book, 2004) [WorldCat.org]
I thought you might be interested in this item at http://www.worldcat.org/oclc/56481955 Title: Constitutional chaos : what happens when the government breaks its own laws Author: Andrew P Napolitano Publisher: Nashville, TN : Nelson Current, a subsidary of Thomas Nelson, Inc., ©2004. ISBN/ISSN: 0785260838 9780785260837 OCLC:56481955
Nashville, TN : Nelson Current, a subsidary of Thomas Nelson, Inc., ©2004.
In this alarming book, Fox News commentator Judge Napolitano makes the solid case that there is a pernicious and ever-expanding pattern of government abuse in America's criminal justice system, leading him to establish his general creed: "The government is not your friend." As an attorney, a law professor, a commentator, a judge, and now a successful television personality, Judge Napolitano has studied the system inside and out, and his unique voice has resonance and relevance. In this sensational book, Napolitano sets the record straight, speaking frankly from his own experiences and investigation about how government agencies will often arrest without warrant, spy without legal authority, imprison without charge, and kill without cause. Read more...
Nashville, TN : Nelson Current, a subsidary of Thomas Nelson, Inc., ©2004
(OCoLC)644261859
0785260838 9780785260837
56481955
Introduction : breaking the law --
The hard test-war on terror --
Prospects for liberty.
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Constitutional chaos : what happens when the government breaks its own laws/Andrew P Napolitano; Nashville, TN : Nelson Current, a subsidary of Thomas Nelson, Inc., ©2004.

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Revision as of 19:02, 18 September 2008 (view source) NishimotoSR (talk | contribs) Newer edit →
Urząd Stanu Cywilnego
(postal code) (name of locality)
POLAND Urząd Stanu Cywilnego
(postal code) (name of locality)
POLAND −[http://www.usc.pl/s_urzedy.php?akcja=info1&id=2405074 Civil Registration address finder]+ +[http://www.usc.pl/s_urzedy.php?akcja=info1&id=2405074 Civil Registration address finder] For the '''Directorate of State Archives''' For the '''Directorate of State Archives''' Revision as of 19:02, 18 September 2008

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Amazon.com: Roman Holiday: Audrey Hepburn, Gregory Peck, Eddie Albert, Hartley Power: Amazon Digital Services LLC
(1,015) IMDb 8.1/10
Eddie Albert, Hartley Power, Harcourt Williams, Margaret Rawlings, Tullio Carminati, Paolo Carlini, Claudio Ermelli, Paola Borboni, Alfredo Rizzo, Laura Solari, Gorella Gori, Armando Ambrogi, Armando Annuale, Maurizio Arena, Silvio Bagolini, Ugo Ballerini, Bruno Baschiera, Gildo Bocci
ByRobin DJWon October 29, 2014
Bytraveler77on December 17, 2014
ByJackalon April 9, 2014
I did not have much knowledge of Audrey Hepburn before watching this film. It is an amazing film because a star is born in front of your eyes. I am not talking as a film historian, but as an emotional human being. You realise that this woman is going to make an impact. I would especially recommend it to people below 40 that probably are not so familiar with this actress. The impact of watching this film will be larger.
5.0 out of 5 starsPrincess abroad
ByE. A. SolinasHALL OF FAMETOP 500 REVIEWERVINE VOICEon September 29, 2008
The Centennial Edition of this movie comes with an extra disk of assorted featurettes -- aside from the usual gallery and trailers, we have a half-hour special on Hepburn's Paramount years, and another twelve minutes commemorating her in general. Also has some stuff on the filming, the costumes, 1950s Paramount, and about restoring the film to primo glory.
5.0 out of 5 starsCritical Review of Roman Holiday
A wonderful movie. It came completely unharmed. My mother (the gift-reciever) loves it and watches it all the time.
A heartwarming romance that reminds us, sometime you have to give up something you love.
Quality is pretty good, the definition is okay, but to be honest it adds to the history of the film. No scratches. Black and White
ByJana M. Simmonson September 14, 2016
This classic movie in black and white is an entertaining and heartwarming story about people doing the right thing. It has a good message and is completely family friendly. I watched it with my 9 and 6 year old daughters and they thoroughly enjoyed it!
5.0 out of 5 starsGrace, Poise and Class all the way
Audre Hepburns debut. This ismy favorite movie of all time. A romantic comedy whose characters have the highest integrity of any film I've ever viewed.Read more
One of my all-time favorite movies! Perfect cast, beautiful story.
Very fun and old movie to watch.
Published 8 days ago by RJMA
Wonderful movie. Well acted and well written.
Hepburn's first and still the best, in my opinion.
Published 20 days ago by TWC
Like all old film with classic actors!
1.0 out of 5 starsWorst Casting Evah!
Actually the whole problem with this film was the casting. Gregory Peck has NO chemistry whatsoever with Audrey Hepburn.Read more
Published 29 days ago by Arthur Van Pelt
Famous old flick in black and white!
3.0 out of 5 starsElizabeth Taylor would have been better
Review of Roman Holiday
Hot Toasty Rag, August 8, 2017
I know Roman Holiday won Audrey Hepburn an Oscar and made her an instant star, so I might be the only person...Read more


text: Misleading AdvertisementsUploaded by Ria SinghRating and Stats0.0 (0)Document ActionsDownloadShare or Embed DocumentEmbedView MoreCopyright: Attribution Non-Commercial (BY-NC)List price: $0.00Download as DOC, PDF, TXT or read online from ScribdFlag for inappropriate contentGROUP 4 - MISLEADING ADVERTISEMENTS (Leader – Neha V.) The Following questions would be explained through your presentation: 1. 2. 3. 4. 5. 6. 7.What are misleading advertisements? Shed light on common misleading advertisements. Why do businesses adopt such practices? Why do they get away with such practices? What are the consequences of such practices? Discuss the role government could play to discourage such practices. What according to you should be the deterrents to stop such practices?


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Half-buried body found in Costa Rica during search for missing Florida woman | Daily Mail Online
Costa Rica's Justice Investigation Department searching for missing Carla Stefaniak on Monday found a woman's body
The body was found partially buried and covered with bags in bakcyard of Stefaniak's Airbnb rental
By Snejana Farberov and Kayla Brantley For Dailymail.com
Published: 16:37 EST, 3 December 2018 | Updated: 17:26 EST, 3 December 2018
According to the country’s Justice Investigation Department, the body was found in the back of the rental property in San Jose, which Stefaniak described in a text message to her sister-in-law as being 'pretty sketchy' last Tuesday night.
According to the Spanish-language news site crhoy.com, specially trained K9 dogs participating in the search for Stefaniak led police to a woman's body in the Escazu neighborhood at around noon local time.

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Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor. - PubMed - NCBI
Format: AbstractFormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListApplySend toChoose DestinationFileClipboardCollectionsE-mailOrderMy BibliographyCitation managerFormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVCreate File1 selected item: 12215427FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataE-mailSubjectAdditional textE-mailDidn't get the message? Find out why...Add to ClipboardAdd to CollectionsOrder articlesAdd to My BibliographyGenerate a file for use with external citation management software.Create File
See comment in PubMed Commons belowJ Biol Chem. 2002 Nov 15;277(46):44028-34. Epub 2002 Sep 4.Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor.Antenos M1, Casper RF, Brown TJ.Author information1Division of Reproductive Sciences, Samuel Lunenfeld Research Institute, Mount Sinai Hospital and Department of Zoology, University of Toronto, Ontario M5G 1X5, Canada.AbstractThe aryl hydrocarbon receptor (AhR) is a ligand-activated member of the basic helix-loop-helix period aryl hydrocarbon nuclear translocator single-minded (PAS) transcription factor family. This receptor has been shown to be important in various aspects of growth and development as demonstrated by AhR-null mice. A yeast two-hybrid screen of a mouse embryonic day 11 library for AhR-interacting proteins revealed Nedd8 as a candidate. The interaction was confirmed in a cell-free system and in mammalian cells by co-immunoprecipitation; however, in vitro neddylation assays showed that Nedd8 does not covalently modify AhR. Transfection of Nedd8 into a cell line stably transfected with a dioxin response element linked to a chloramphenicol acetyltransferase reporter gene demonstrated that Nedd8 amplified ligand-induced transcription. Deletion of the Gly-76 residue in the carboxyl terminus of Nedd8 abolished this effect and prevented AhR-Nedd8 interaction. Nedd8 overexpression also resulted in accumulation of AhR protein in the nucleus, independent of exogenous ligand. These studies demonstrate that the AhR interacts with Nedd8 and suggest that this interaction enhances the transcriptional activity of the receptor, perhaps involving increased nuclear accumulation or retention. Immunohistochemistry performed on embryonic day 11.5 mouse sections indicated Nedd8 and AhR localize to overlapping areas in the heart and spinal ganglia, raising the possibility that this interaction may play a role in organogenesis.PMID: 12215427 DOI: 10.1074/jbc.M202413200 [PubMed - indexed for MEDLINE] Free full textSharePublication Types, MeSH Terms, SubstancesPublication TypesResearch Support, Non-U.S. Gov'tMeSH TermsAnimalsCell Nucleus/metabolismCell-Free SystemCells, CulturedChloramphenicol O-Acetyltransferase/metabolismCytosol/metabolismDNA, Complementary/metabolismDimerizationElectrophoresis, Polyacrylamide GelGenetic VectorsImmunoblottingImmunohistochemistryMiceMice, Inbred ICRMicroscopy, FluorescencePrecipitin TestsProtein BindingProtein BiosynthesisReceptors, Aryl Hydrocarbon/metabolism*Transcription, Genetic*Transcriptional ActivationTransfectionTwo-Hybrid System TechniquesUbiquitin/metabolism*Ubiquitins/chemistry*Ubiquitins/metabolism*SubstancesDNA, ComplementaryNedd8 protein, mouseReceptors, Aryl HydrocarbonUbiquitinUbiquitinsChloramphenicol O-AcetyltransferaseLinkOut - more resourcesOther Literature SourcesCOS Scholar UniverseMolecular Biology DatabasesGene Ontology annotations from this paper - Gene OntologyKOMP RepositoryMouse Genome Informatics (MGI)PubMed Commons home

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OLD GREEN ENAMEL SQUARE METAL PORCELAIN LIGHT SHADE GAS STATION BARN LAMP | eBay Please enable JavaScript Our new search experience requires JavaScript to be enabled. Please enable JavaScript on your browser, then try again.
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IT Specialist Jobs, Employment in Hurst, TX
IT Specialist jobs in Hurst, TX
Arounds, testing & implementation of vendor / IT fixes or design changes. Responsible for the requirements, testing, planning & implementation of....
Act as a liaison between the IT and business teams to ensure that all requirements and user stories are accurate and fully detailed....
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The Associate Technical Support Specialist provides technical assistance to customers on the use of Omnitracs’ supported mobile systems and applications....
View all Omnitracs jobs in Dallas, TX - Dallas jobsSalary Search: Entry Level Help Desk Representative salaries in Dallas, TXLearn more about working at OmnitracsRelated forums: OMNITRACS - Help Desk Representative - Dallas, Texas
Network +, Security +, Microsoft Certified Desktop Support Technician (MCDST) or Microsoft Certified IT Professional (MCITP)....
View all City of Farmers Branch jobs in Farmers Branch, TX - Farmers Branch jobsSalary Search: System Support Specialist salaries in Farmers Branch, TXRelated forums: City of Farmers Branch, TX - Farmers Branch, Texas - -
Ability to work with general direction on problems related to IT training. Train teammates on electronic medical record (EMR) systems -- both during New...
View all Presbyterian Communities and Services jobs in Irving, TX - Irving jobsSalary Search: Clinical IT Specialist salaries in Irving, TXLearn more about working at Presbyterian Communities and ServicesRelated forums: Irving, Texas - Presbyterian Communities and Services - -
Organize and instantly access what they need, when they need it and safeguard their most important records with vault-level protection....
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Do you have what it takes to be technical leader in this evolution? It provides an operating system and a set of developer services that can be used...
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SoftLayer Information Technology Specialist (Evening Shift)
IT Specialist's are responsible for deploying, monitoring, and maintaining complex solutions to meet the needs of the business and our customers....
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Assists VP of IT Systems or management in developing, implementing and enforcing I.T. Assists VP of IT Systems with disaster recovery planning and testing, and...
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The Controls Systems Specialist (CSS) will ensure that Safety comes first in all Facilities efforts. Work with IT, FC Software and Operations Engineering tp...
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BrowseBrowseInterestsBiography & MemoirBusiness & LeadershipFiction & LiteraturePolitics & EconomyHealth & WellnessSociety & CultureHappiness & Self-HelpMystery, Thriller & CrimeHistoryYoung AdultBrowse byBooksAudiobooksComicsSheet MusicBrowse allUploadSign inJoinBooksAudiobooksComicsSheet MusicJoint StatementUploaded by thedailybeast994 viewsDownloadEmbedSee MoreCopyright: Attribution Non-Commercial (BY-NC)Download as PDF, TXT or read online from ScribdFlag for inappropriate contentJoint Statement from George J.Tenet, Cofer Black and Richard Blee
Richard Clarke was an able public servant who served his country well for many years. But his recently released comments about the run up to 9/11 are reckless and profoundly wrong. Clarke starts with the presumption that important information on the travel of future hijackers to the United States was intentionally withheld from him in early 2000. It was not. He wildly speculates that it must have been the CIA Director who could have ordered the information withheld. There was no such order. In fact, the record shows that the Director and other senior CIA officials were unaware of the information until after 9/11. The handling of the information in question was exhaustively looked at by the 9/11 Commission, the Congressional Joint Inquiry, the CIA Inspector General and other groups. The 9/11 Commission quite correctly concluded that “It appears no one informed higher levels of management in either the FBI or CIA about the case.” In early 2000, a number of more junior personnel (including FBI agents on detail to CIA) did see travel information on individuals who later became hijackers but the significance of the data was not adequately recognized at the time. Since 9/11 many systemic changes have been made to improve the watchlisting process and enhance information sharing within and across agencies. Building on his false notion that information was intentionally withheld, Mr. Clarke went on to speculate--which he admits is based on nothing other than his imagination--that the CIA might have been trying to recruit these two future hijackers as agents. This, like much of what Mr. Clarke said in his interview, is utterly without foundation. Many years after testifying himself at length before the 9/11 Commission but making no mention of his wild theory, Mr. Clarke has suddenly invented baseless allegations which are belied by the record and unworthy of serious consideration. We testified under oath about what we did, what we knew and what we didn't know. We stand by that testimony. ###


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Coach Ken Whisenhunt said there's no edge for Arizona Cardinals QBs Josh Skelton, Kevin Kolb - ESPN
QB decision up in air to start
FLAGSTAFF, Ariz. -- The battle for the Arizona Cardinals' starting quarterback job has entered its crucial final phase with Kevin Kolb and John Skelton splitting reps in the first workout of training camp on Wednesday.By all accounts, it's a friendly rivalry with no animosity apparent between two players with low-key personalities. Coach Ken Whisenhunt insists it's an open competition and that neither player has an edge, despite the big investment the franchise has made in Kolb.Whisenhunt, who knows that this subject will hover over training camp until he announces a winner, facetiously answered a question on the criteria for the job."Who took a shower that day, if they comb their hair or not, how closely shaved they were," he said.Then he turned serious."It's not one or two things," the coach said. "I think that position involves so many different skill sets that have to operate at once that you're evaluating how they handle different components, if their progressions on their reads were sound."Whisenhunt was displeased with a comment by analyst Willie McGinest, who said on the NFL Network that "talking to some of my buddies down there, it seems like they're (the players) gravitating toward Skelton a little bit more.""I have no perception whatever that that's going on," Whisenhunt said. "From what I've seen, standing in the huddle, which I don't believe he was in the huddle, the team's responded to both guys and feel like both guys can be successful for them. So I don't put a whole lot of stock into that. If he's willing to say who it was or what they're talking about and what context, maybe it would be worthy of commenting."Larry Fitzgerald said he couldn't fathom where such comments would have originated."I haven't heard that," he said. "I've heard some guys say we want the best guy to lead our team, I've heard that, but I haven't heard anybody leaning towards anybody. ... You never want to go off the record like that behind people's back. That's not becoming of a Cardinal."Said guard Daryn Colledge, "I don't' know who Willie's guy is, but I speak for the offensive line, we have no favorites."Fitzgerald said this quarterback competition is far different than when Matt Leinart and Kurt Warner were battling for the position in 2008. Whisenhunt waited until just before the season started to give the job to Warner, who went on to lead the Cardinals to the Super Bowl."The dynamics were totally different," Fitzgerald said. "Matt was a Heisman Trophy winner, high draft pick, coming in with all the hoopla. Kurt was your Super Bowl MVP, two-time league MVP, did he still have enough in the tank to get it done. This one is kind of different because both the guys aren't household names, so to speak."Kolb was 2-6 as a starter last year, missing much of the season with turf toe and later a concussion. Skelton was 6-2 in his absence, but much of the credit for that success goes to the team's vastly improved defense.Skelton said he and Kolb spend a lot of time together, that they were among about a dozen Cardinals who played golf every Tuesday in the offseason."I guess it's hard for the outside community to fathom," Skelton said, "two guys getting along that are competing for the same job but we both push each other, we both want the best for each other. That's the way we are in life as well as in football."The Cardinals thought they had acquired their franchise quarterback when they sent cornerback Dominique Rodgers-Cromartie and a draft pick to Philadelphia for Kolb, then signed him to a five-year, $63 million contract -- with $21 million guaranteed.But with no offseason because of the lockout, Kolb struggled to absorb the Cardinals' offense then was sidelined with injury. Skelton replaced him, and though his passing often was erratic, he had a knack for bringing the team from behind in the fourth quarter.Kolb said he's far more comfortable than he was a year ago."Everything about it is a lot more comfortable, the drive up, being here with my teammates is obviously the most important thing, and the playbook," Kolb said.Kolb repeatedly has said he doesn't mind having to fight for his job."I've said it a thousand times, that's part of being in the NFL," he said. "Adam (Snyder) and I were talking on the way over here, he's never been to a season where he didn't have to compete for his own job. Every player in the NFL is used to it, I'm used to it and look forward to doing my best."Skelton, a fifth-round draft pick out of Fordham entering his third NFL season, said he understands the constant scrutiny of "probably the most important position on the field.""But Kevin and I are both taking it stride," he said. "We both know that we're going to push each other like always and may the best man win."Copyright 2012 by The Associated PressRecommend0

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Thanks,MattOn Thu, Apr 10, 2014 at 9:00 PM, Shawn Crowe <shawn@doap.com> wrote:
I'm still seeing some errors after updating..!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
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Environment variable is:LANG=en_US.UTF-8Original filename is:397x200_1397137668_Taiw�n.JPG
Any suggestions?Thanks,ShawnOn Sat, Apr 5, 2014 at 11:56 AM, Matt Domsch <matt@domsch.com> wrote:
> S3cmd: � 1.5.0-alpha3
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> � � Please report the above lines to:
> � �s3tools-bugs@lists.sourceforge.net

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BBC Two - Hebburn, Series 1, Feeling Dynamic - QR code We use cookies to ensure that we give you the best experience on our website. We also use cookies to ensure we show you advertising that is relevant to you. If you continue without changing your settings, we'll assume that you are happy to receive all cookies on the BBC website. However, if you would like to, you can change your cookie settings at any time. Continue Find out more ]]> Accessibility links Skip to content Skip to local navigation Accessibility Help BBC iD BBC iD Settings Sign out BBC navigation News Sport Weather Capital Culture Shop TV Radio More… Search term: BBC TwoHebburn
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A scripted SQL query generation framework with IDE: SQLpp (v1.4) - CodeProject 10,866,999 members (72,990 online)
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Crocheted Comfy crop top free worldwide shipping
Made from my own pattern - this simply pretty crop top would be a cool for warm days.
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Amazon.com: Customer Reviews: Seasonal Fruit Desserts: From Orchard, Farm, and Market
Customer Reviews4.7 out of 5 stars174.7 out of 5 stars5 star82%4 star6%3 star12%2 star0%1 star0%Seasonal Fruit Desserts: From Orchard, Farm, and MarketbyDeborah MadisonFormat: Hardcover|ChangeYour rating(Clear)Rate this itemYour rating
Top positive reviewSee all 15 positive reviews› 19 people found this helpful5.0 out of 5 starsGreat Cookbook with a Passion For Fresh, Local, & SeasonalByLynn Craigon May 4, 2010I love the focus of this cookbook. Deborah Madison has packed the book with terrific recipes using fresh fruits, as well as lots of information nuggets about why it makes a difference to buy locally. The mouthwatering photography tempts me to try every recipe in the book. So far I've made cookies from the book (everyone loved them), and can't wait for more fruit to become available at the farmer's markets to try many more recipes.
Top critical reviewSee all 2 critical reviews› 7 people found this helpful3.0 out of 5 starsGood on fruit dessertsByBlue in Washingtonon May 9, 2011This is a slickly produced publication with some interesting ideas for fruit desserts most especially. Some new stuff in the area of tarts. Illustrations are glossy, but surprisingly sparse when it comes to match-ups with the recipes. I've started using the book--it was a gift--but I'm wondering if I would have bought it otherwise with so many other convenient ways to obtain and use recipes these days. At this point in my relationship with the work, I think that its great strength is that the author of the book steers you towards tastes, ingredients and accompaniments that you wouldn't otherwise conjure up for yourself. Maybe that's what cookbooks (as opposed to Epicurious, magazines, the weekly food section of the newspaper) are good for anymore.
All reviewersVerified purchase onlyAll reviewersAll stars5 star only4 star only3 star only2 star only1 star onlyAll positiveAll criticalAll starsAll formatsFormat: HardcoverAll formatsSearchThere was a problem filtering reviews right now. Please try again later.5.0 out of 5 starsGreat Cookbook with a Passion For Fresh, Local, & SeasonalByLynn Craigon May 4, 2010Format: HardcoverI love the focus of this cookbook. Deborah Madison has packed the book with terrific recipes using fresh fruits, as well as lots of information nuggets about why it makes a difference to buy locally. The mouthwatering photography tempts me to try every recipe in the book. So far I've made cookies from the book (everyone loved them), and can't wait for more fruit to become available at the farmer's markets to try many more recipes.22 comments|19 people found this helpful. Was this review helpful to you?YesNoReport abusePlease write at least one wordYou must purchase at least one item from Amazon to post a commentA problem occurred while submitting your comment. Please try again later.Sign in and comment
There was a problem loading comments right now. Please try again later.4.0 out of 5 starsI like this.ByMicrobeson July 25, 2013Format: Hardcover|Verified PurchaseI had checked out this book from the library to see if I liked it, and I did, so I ordered it. My only criticism is that for my taste, she doesn't use quite enough sugar, and I don't like things intensely sweet. That is easily remedied, so I know I'm going to like having this.0Comment|4 people found this helpful. Was this review helpful to you?YesNoReport abusePlease write at least one wordYou must purchase at least one item from Amazon to post a commentA problem occurred while submitting your comment. Please try again later.Sign in and comment
There was a problem loading comments right now. Please try again later.5.0 out of 5 starsIf You Love Fruit Desserts, This Is For YouByMarilynon October 29, 2013Format: Hardcover|Verified PurchaseThis book is as beautiful as the first one I ordered. Fruit is my favorite dessertand I look forward to making all of them. The book itself is outstanding. It is apleasure to cook from her books. They are as pretty to look as well as cook from.0Comment|2 people found this helpful. Was this review helpful to you?YesNoReport abusePlease write at least one wordYou must purchase at least one item from Amazon to post a commentA problem occurred while submitting your comment. Please try again later.Sign in and comment
There was a problem loading comments right now. Please try again later.5.0 out of 5 starsGreat GiftByA. Bowmanon April 13, 2013Format: Hardcover|Verified PurchaseMy mother-in-law read about this book in a magazine, and proceeded to try a recipe that was printed from the book, then told us about what a great book it might be... so we ordered a copy to surprise her for her birthday. She was surprised and was happy that it turned out to be the great book she thought it might be.0Comment|One person found this helpful. Was this review helpful to you?YesNoReport abusePlease write at least one wordYou must purchase at least one item from Amazon to post a commentA problem occurred while submitting your comment. Please try again later.Sign in and comment
There was a problem loading comments right now. Please try again later.5.0 out of 5 stars1st baking and desserts cookbook by a celebrated chef and cookbook writerBydatura2002on April 15, 2010Format: HardcoverAs summer approaches, the farmer's market season begins in earnest. I plan on going to market to buy delicious fruit (and heading out to local farms and picking my own!). Although I'll eat a lot of it straight, I also want to bake some into desserts, and this is one of the first cookbooks I'm going to use.This is the first baking/desserts-only cookbook from Deborah Madison, IACP and James Beard award-winning cookbook writer of Vegetarian Cooking for Everyone and The Greens Cookbook. Her recipes are reliable, but accessible for a home cook who doesn't want a lot of fuss.Madison loves fruit, particular fresh regionally-distinctive produce, and her expertise on growing seasons and different fruit varieties across the United States shines here.I'm particularly looking forward to summer, when I'll be able to make the Wild Blueberry Tart in a Brown Sugar Crust, and the Strawberries in Red Wine Syrup.11 comment|28 people found this helpful. Was this review helpful to you?YesNoReport abusePlease write at least one wordYou must purchase at least one item from Amazon to post a commentA problem occurred while submitting your comment. Please try again later.Sign in and comment
There was a problem loading comments right now. Please try again later.5.0 out of 5 starsMore classicsBykarenon May 21, 2013Format: Hardcover|Verified PurchaseMore truly fresh and wonderful, not too complicated, recipes from Deborah Madison----it's a great addition to my extensive library of cookbooks!0Comment|Was this review helpful to you?YesNoReport abusePlease write at least one wordYou must purchase at least one item from Amazon to post a commentA problem occurred while submitting your comment. Please try again later.Sign in and comment
There was a problem loading comments right now. Please try again later.5.0 out of 5 starsGreat!ByMooon January 3, 2015Format: HardcoverI bought this for a gift. My cousin LOVES it. I like the way Deborah Madison talks food so to speak. Great purchase for self or others.0Comment|Was this review helpful to you?YesNoReport abusePlease write at least one wordYou must purchase at least one item from Amazon to post a commentA problem occurred while submitting your comment. Please try again later.Sign in and comment
There was a problem loading comments right now. Please try again later.5.0 out of 5 starsInspirational Dessert BookBywildflowerlenson July 3, 2013Format: Hardcover|Verified PurchaseI love everything that Deborah Madison has published. This book has many recipes that I am eager to try, based on seasonal fruits.0Comment|Was this review helpful to you?YesNoReport abusePlease write at least one wordYou must purchase at least one item from Amazon to post a commentA problem occurred while submitting your comment. Please try again later.Sign in and comment
There was a problem loading comments right now. Please try again later.5.0 out of 5 starsGreat fruit cookbookByCynthia Johnsonon April 23, 2015Format: Hardcover|Verified PurchaseWho doesn't love fruit? And now there are more ways of enjoying them and easy to follow.0Comment|Was this review helpful to you?YesNoReport abusePlease write at least one wordYou must purchase at least one item from Amazon to post a commentA problem occurred while submitting your comment. Please try again later.Sign in and comment
There was a problem loading comments right now. Please try again later.5.0 out of 5 starsFive StarsByS. Byarson October 29, 2014Format: Hardcover|Verified PurchaseHas some good desserts, I am looking forward to trying them out.0Comment|Was this review helpful to you?YesNoReport abusePlease write at least one wordYou must purchase at least one item from Amazon to post a commentA problem occurred while submitting your comment. Please try again later.Sign in and comment
Customers also viewed these itemsThe New Vegetarian Cooking for EveryonebyDeborah Madison$27.294.4 out of 5 stars107Vegetable Literacy: Cooking and Gardening with Twelve Families from the Edible Plant...byDeborah Madison$25.004.6 out of 5 stars189The Love and Lemons Cookbook: An Apple-to-Zucchini Celebration of Impromptu CookingbyJeanine Donofrio$20.834.6 out of 5 stars55The Savory WaybyDeborah Madison4.8 out of 5 stars18Send us feedbackHow can we make Amazon Customer Reviews better for you?Let us know here.‹ See all details for Seasonal Fruit Desserts: From Orchard, Farm, and Market


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2 bedroom end of terrace house for sale in Turner Road, Chapelfields, Coventry, West Midlands, CV5
www.rightmove.co.uk/property/45581022
Turner Road, Chapelfields, Coventry, West Midlands
Here we have an opportunity to acquire a single bay extended end-of-terrace town house in a cul-de-sac position in the popular residential area of Chapelfields which is located on the West side of the City. In brief, the accommodation comprises: entrance porch, entrance lobby, good size lounge with feature fireplace, kitchen dining room, utility room, store and ground floor cloakroom WC. On the first floor there is a landing, two bedrooms and a bathroom WC. Outside there is a fore garden and a larger-than-average rear garden having vehicular access and a garage.
The property benefits from double glazing and gas fired central heating. All local amenities are within easy reach as well as access to the Midland Motorway Network, Coventry and Canley Train Stations and Birmingham International Airport. We would strongly recommend an internal inspection of this property to appreciate its size and location.
Disclaimer - Property reference 102311021250. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by Brian Holt, Earlsdon. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.
06 Jan 2017 57 Turner Road, CV5 £142,000
01 Apr 2016 41 Turner Road, CV5 £139,000
05 Feb 2016 73 Turner Road, CV5 £124,000

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Los Angeles Dodgers acquire Ricky Nolasco, Miami Marlins pitcher - ESPN
Updated: July 7, 2013, 1:55 AM ET
The Los Angeles Dodgers made their major splash after the trade deadline last season, but this time they pounced early, landing starting pitcher Ricky Nolasco from the Miami Marlins on Saturday in exchange for minor league pitchers Steven Ames, Josh Wall and Angel Sanchez.
"Going to play for the Dodgers, the team that I have always rooted for, is a dream come true," Nolasco said in a statement. "The team is packed with talent and an ownership group that is committed to winning, and I'd like nothing more than to play a part in bringing a World Series back to L.A. I couldn't be more excited to play in front of my family and friends in Dodger stadium during this season and hopefully for many more seasons to come."
More from ESPN.com By acquiring Ricky Nolasco from the Marlins for three minor leaguers, the Dodgers got the starter they desperately needed and Miami reminded local taxpayers that it was a very bad idea to trust Jeff Loria, writes Keith Law. Blog The Dodgers also acquired relief from the international signing bonus limits valued at $197,000. They received similar compensation in an earlier deal with the Chicago Cubs in a swap of relievers acquiring Carlos Marmol from the Chicago Cubs for Matt Guerrier. The Dodgers are intent on rebuilding their sagging farm system and have made a serious push in global scouting under the Guggenheim ownership group.
"We needed to add to our pitching and to acquire someone like Ricky and, with weeks to go before the deadline, we thought this was the best move for us," Dodgers general manager Ned Colletti said. "Also, adding another $197,000 to the international pool doesn't hurt. We've added more than $400,000 in the last few days and, with our expanded international staff, it gives us additional opportunities to build our system.
"We've liked Ricky for a while. He's a gamer, a quiet, focused and successful pitcher who can add depth to our rotation."
The Dodgers now would like to add a reliever before the July 31 trade deadline and figure to hold on to their veteran core now that they have pulled to within 3½ games of the first-place Arizona Diamondbacks.
The Dodgers feel their top three starters of Clayton Kershaw, Zack Greinke and Hyun-Jin Ryu can stack up with any rotation in baseball, but they wanted to fortify the back end, which has been tattered by injuries to Chad Billingsley, Josh Beckett and Ted Lilly. Nolasco is expected to take the rotation spot of Chris Capuano, who figures to return to the bullpen.
Wall, 26, has spent parts of the past two seasons with the Dodgers, going 1-1 with a 12.08 ERA. Ames, 25, is 2-2 with a 3.67 ERA in 30 games for Triple-A Albuquerque. Sanchez, 23, is 2-7 with a 4.67 ERA in 16 games between Single-A stops at Great Lakes and Rancho Cucamonga.
A year ago, the Dodgers made a blockbuster trade with the Boston Red Sox in August, acquiring Adrian Gonzalez, Beckett, Carl Crawford and Nick Punto in exchange for James Loney and four prospects. The Dodgers took on more than $250 million in that deal. They will pay Nolasco's $5.5 million salary for the rest of the season.
Information from ESPN.com's Jayson Stark and ESPNLosAngeles.com's Mark Saxon was used in this report.
Sources: Marlins want Nolasco traded soon
MORE FROM ESPN LOS ANGELES Check out the new ESPN Los Angeles, the place for your local Los Angeles sports coverage. Scott not wasting time: Lakers must play D