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Patent US6081736 - Implantable enzyme-based monitoring systems adapted for long term use - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsImproved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the following:...http://www.google.com/patents/US6081736?utm_source=gb-gplus-sharePatent US6081736 - Implantable enzyme-based monitoring systems adapted for long term useAdvanced Patent SearchPublication numberUS6081736 APublication typeGrantApplication numberUS 08/953,817Publication dateJun 27, 2000Filing dateOct 20, 1997Priority dateOct 20, 1997Fee statusPaidAlso published asUS6512939Publication number08953817, 953817, US 6081736 A, US 6081736A, US-A-6081736, US6081736 A, US6081736AInventorsMichael S. Colvin, Joseph H. Schulman, Lyle Dean Canfield, Rajiv ShahOriginal AssigneeAlfred E. Mann FoundationExport CitationBiBTeX, EndNote, RefManPatent Citations (17), Non-Patent Citations (2), Referenced by (145), Classifications (7), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetImplantable enzyme-based monitoring systems adapted for long term use
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4431004 *Oct 27, 1981Feb 14, 1984Bessman Samuel PImplantable glucose sensorUS4484987 *May 19, 1983Nov 27, 1984The Regents Of The University Of CaliforniaMethod and membrane applicable to implantable sensorUS4627906 *Aug 22, 1985Dec 9, 1986The Regents Of The University Of CaliforniaElectrochemical sensor having improved stabilityUS4650547 *Dec 20, 1985Mar 17, 1987The Regents Of The University Of CaliforniaManagement of diabetesUS4671288 *Jun 13, 1985Jun 9, 1987The Regents Of The University Of CaliforniaElectrochemical cell sensor for continuous short-term use in tissues and bloodUS4703756 *May 6, 1986Nov 3, 1987The Regents Of The University Of CaliforniaDifferential measurement, oxygen sensors, glucose oxidaseUS4721677 *May 7, 1987Jan 26, 1988Children's Hospital Medical CenterImplantable gas-containing biosensor and method for measuring an analyte such as glucoseUS4759828 *Apr 9, 1987Jul 26, 1988Nova Biomedical CorporationGlucose electrode and method of determining glucoseUS4781798 *May 8, 1987Nov 1, 1988The Regents Of The University Of CaliforniaTransparent multi-oxygen sensor array and method of using sameUS4890620 *Feb 17, 1988Jan 2, 1990The Regents Of The University Of CaliforniaTwo-dimensional diffusion glucose substrate sensing electrodeUS4919141 *Jan 4, 1988Apr 24, 1990Institute fur Diabetestechnologie Gemeinnutzige Forschungs- und Entwicklungsgesellschaft mbHFor measuring blood and tissue sugar in diabetics; portable, lightweight, biocompatibleUS5165407 *Apr 9, 1991Nov 24, 1992The University Of KansasImplantable glucose sensorUS5174291 *May 15, 1990Dec 29, 1992Rijksuniversiteit Te GroningenProcess for using a measuring cell assembly for glucose determinationUS5497772 *Nov 19, 1993Mar 12, 1996Alfred E. Mann Foundation For Scientific ResearchGlucose monitoring systemUS5624537 *Sep 20, 1994Apr 29, 1997The University Of British Columbia - University-Industry Liaison OfficeSupported permselective membrane having perfluorosulfonic acid polymer impregnated substrate with electrode and protein-receiving matrixUS5711861 *Nov 22, 1995Jan 27, 1998Ward; W. KennethDevice for monitoring changes in analyte concentrationUS5791344 *Jan 4, 1996Aug 11, 1998Alfred E. Mann Foundation For Scientific ResearchPatient monitoring system* Cited by examinerNon-Patent CitationsReference1Gough, et al.; "Two-Dimensional Enzyme Electrode Sensor for Glucose", Analytical Chemistry, vol. 57, No. 12, pp. 2351-2357 (1985).2 *Gough, et al.; Two Dimensional Enzyme Electrode Sensor for Glucose , Analytical Chemistry , vol. 57, No. 12, pp. 2351 2357 (1985).* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS6343225 *Sep 14, 1999Jan 29, 2002Implanted Biosystems, Inc.Implantable glucose sensorUS6383767 *Jan 21, 2000May 7, 2002Motorola, Inc.Luminescent in vivo glucose measurementUS6516808Jun 14, 2001Feb 11, 2003Alfred E. Mann Foundation For Scientific ResearchHermetic feedthrough for an implantable deviceUS6558321Aug 11, 2000May 6, 2003Dexcom, Inc.Systems and methods for remote monitoring and modulation of medical devicesUS6572566 *Feb 27, 2001Jun 3, 2003Roche Diagnostics CorporationSystem for determining analyte concentrations in body fluidsUS6585644 *Jan 22, 2001Jul 1, 2003Medtronic Minimed, Inc.Ambulatory medical apparatus and method using a telemetry system with predefined reception listening periodsUS6694158Apr 11, 2001Feb 17, 2004Motorola, Inc.System using a portable detection device for detection of an analyte through body tissueUS6733446Jan 22, 2001May 11, 2004Medtronic Minimed, Inc.Ambulatory medical apparatus and method using a telemetry system with predefined reception listening periodsUS6815186Jan 28, 2002Nov 9, 2004Implanted Biosystems, Inc.Implantable glucose sensorUS6931327Aug 1, 2003Aug 16, 2005Dexcom, Inc.System and methods for processing analyte sensor dataUS6950708Jul 29, 2002Sep 27, 2005Medtronic Minimed, Inc.Ambulatory medical apparatus and method using a telemetry system with predefined reception listeningUS6974437Jan 22, 2001Dec 13, 2005Medtronic Minimed, Inc.Microprocessor controlled ambulatory medical apparatus with hand held communication deviceUS6975893 *Nov 25, 2003Dec 13, 2005Therasense, Inc.Mass transport limited in vivo analyte sensorUS7069078Apr 22, 2002Jun 27, 2006Medtronic, Inc.Insulin-mediated glucose uptake monitorUS7074307Jul 21, 2004Jul 11, 2006Dexcom, Inc.transdermal and implantable biosensors comprising membranes having immobilized enzymes, anodes and cathodes, used for analyzing glucose, uric or ascorbic acidUS7081195Dec 7, 2004Jul 25, 2006Dexcom, Inc.Systems and methods for improving electrochemical analyte sensorsUS7108778Jul 21, 2004Sep 19, 2006Dexcom, Inc.Electrochemical sensors including electrode systems with increased oxygen generationUS7127286Oct 26, 2001Oct 24, 2006Second Sight Medical Products, Inc.Implantable device using ultra-nanocrystalline diamondUS7162289 *Dec 31, 2002Jan 9, 2007Medtronic Minimed, Inc.Method and apparatus for enhancing the integrity of an implantable sensor deviceUS7226442Oct 10, 2001Jun 5, 2007Microchips, Inc.Microchip reservoir devices using wireless transmission of power and dataUS7276029Aug 1, 2003Oct 2, 2007Dexcom, Inc.System and methods for processing analyte sensor dataUS7303543Dec 3, 2004Dec 4, 2007Medtronic Minimed, Inc.Medication infusion setUS7324012Sep 12, 2005Jan 29, 2008Medtronic Minimed, Inc.Telemetered characteristic monitor system and method of using the sameUS7344500Jul 27, 2004Mar 18, 2008Medtronic Minimed, Inc.Sensing system with auxiliary displayUS7366556Oct 4, 2006Apr 29, 2008Dexcom, Inc.Dual electrode system for a continuous analyte sensorUS7410616Sep 6, 2007Aug 12, 2008Microchips, Inc.Device for the controlled exposure of reservoir-based sensorsUS7424318Oct 4, 2006Sep 9, 2008Dexcom, Inc.Dual electrode system for a continuous analyte sensorUS7445766Apr 10, 2006Nov 4, 2008Microchips, Inc.Miniaturized device; substrate with reservoirs, openings; barriers layer covering apertureUS7455667Oct 26, 2005Nov 25, 2008Microchips, Inc.Controlled release device and method using electrothermal ablationUS7460898Oct 4, 2006Dec 2, 2008Dexcom, Inc.Dual electrode system for a continuous analyte sensorUS7467003Oct 4, 2006Dec 16, 2008Dexcom, Inc.Dual electrode system for a continuous analyte sensorUS7473248Dec 29, 2003Jan 6, 2009Microchips, Inc.Thermally-activated reservoir devicesUS7473548Apr 25, 2003Jan 6, 2009Medtronic, Inc.Medical devices that detect thrombin and kallikrein within bodily fluid; substrate is tagged with two fluorescent dyes a donor and an acceptor. tagged substrate is presented to the bodily fluid, device emits energy at a first wavelength into the bodily fluid, and detects energyUS7488316Jan 25, 2006Feb 10, 2009Microchips, Inc.Improved delivery of drug formulations, protein drugs, from implanted medical devices, drug is stored as a solid or in concentrated, rather than dilute, solutions; decreased time required for dose of a drug formulation to be released from device; inhibition of gelation, aggregation, or precipitationUS7496392Nov 26, 2003Feb 24, 2009Becton, Dickinson And CompanyFiber optic device for sensing analytesUS7510551Aug 15, 2003Mar 31, 2009Microchips, Inc.Controlled release device and method using electrothermal ablationUS7521019Apr 11, 2001Apr 21, 2009Lifescan, Inc.Seamless apparatus for use in the detection of preferential particles in sampleUS7552522 *Aug 26, 2004Jun 30, 2009Medtronic Minimed, Inc.Method of making a sensing apparatusUS7555328 *Mar 29, 2006Jun 30, 2009Alfred E. 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Inc.couples a sensor electronics device to the sensor and measures the open circuit potential between at least two of the plurality of electrodesUS8152764Mar 18, 2010Apr 10, 2012Medtronic Minimed, Inc.Modular external infusion deviceUS8162876Oct 18, 2007Apr 24, 2012Medtronic Minimed, Inc.Medication infusion setUS8165651Dec 7, 2004Apr 24, 2012Abbott Diabetes Care Inc.Analyte sensor, and associated system and method employing a catalytic agentUS8182447Oct 22, 2009May 22, 2012Medtronic Minimed, Inc.Methods and apparatuses for detecting occlusions in an ambulatory infusion pumpUS8182462Sep 13, 2010May 22, 2012Medtronic Minimed, Inc.Modular external infusion deviceUS8214032Jun 12, 2006Jul 3, 2012Second Sight Medical Products, Inc.Implantable device using ultra-nanocrystalline diamondUS8249683Jun 29, 2010Aug 21, 2012Medtronic Minimed, Inc.Real-time self-calibrating sensor system and methodUS8252158Oct 23, 2007Aug 28, 2012Honeywell International Inc.Oxygen sensorsUS8267893Oct 5, 2011Sep 18, 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Classification600/377, 600/347, 600/365International ClassificationA61B5/00Cooperative ClassificationA61B5/0031, A61B5/14865European ClassificationA61B5/1486BLegal EventsDateCodeEventDescriptionDec 27, 2011FPAYFee paymentYear of fee payment: 12Sep 14, 2007FPAYFee paymentYear of fee payment: 8Sep 26, 2003FPAYFee paymentYear of fee payment: 4Mar 27, 1998ASAssignmentOwner name: ALFRED E, MANN FOUNDATION, CALIFORNIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:COLVIN, MICHAEL S.;SCHULMAN, JOSEPH H.;CANFIELD, LYLE D.;AND OTHERS;REEL/FRAME:009070/0502;SIGNING DATES FROM 19980309 TO 19980313RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services

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9780860123408 - Alibris
ISBN: 9780860123408
0860123405
9780860123408
Butler's Lives of the Saints: New Concis
ISBN-13: 9780860123408
ISBN: 0860123405
Alibris ID: 14828453275
Butler's Lives of the Saints: Concise Edition
by Alban Butler, Paul Burns
2003, Burns & Oates Ltd
Alibris ID: 14828448243
$12.49 $31.95
Alibris ID: 14828444507
Alibris ID: 14236919698
Very Good. Trade paperback (US). Glued binding. Daily Devo.
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Alibris ID: 14041788162
Fine. Trade paperback (US). Glued binding. Daily Devo.
Alibris ID: 14865181433
Very Good. Saints belong to the whole history of the church but are especially visible today. This work provides a fresh consideration of one saint or blessed for daily reading. The aim is to give a simple, factual presentation of flesh and blood figures. Trade paperback (US). Glued binding. Daily Devo.
by Alban Butler, Paul Burns (Editor)
$18.42 $31.95
Alibris ID: 14266180919
by Butler, Alban, and Burns, Paul (Editor)
Alibris ID: 12142325743
New. Absolutely brand new(never opened)! ! -No international shipping available[hyn2] Trade paperback (US). Glued binding. Audience: General/trade.
Alibris ID: 14677213931
The Lives of the Fathers, Martyrs, and Other Principal Saints; Compiled from Original Monuments, and Other Authentic Records V4

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Local 1776 represents workers in Philadelphia and the surrounding suburbs for the United Food and Commercial Workers. The larger majority of their members work in grocery stores. The number 1776 refers to the historical date in Philadelphia rather than it being a sequential number of local unions.
In 1937, The Retail Clerks & Managers Protective Association (retail clerks) Local 1357 was founded in Philadelphia by employees of American Stores and A&P. Then in 1963, Local 1357 of the retail clerks had 4,000 members in Philadelphia area supermarkets. By the end of the decade, through the organizing power of president Wendell Young III over 10,000 non-food retail workers and department store employees joined Local 1357. In 1971, Pennsylvania State Liquor Store clerks joined the ranks of the expanding union. Food processing workers boot & shoe factory workers, health care workers, clerical and professional administrators as well as insurance agents and barbers, hairdressers and cosmetologists all unified during throughout the course of the 1980s. To celebrate the newfound unity of so diverse a union membership, Local 1357 changed to the historic Local number "1776" in May 1989. Through President Wendell Young III's skills as an organizer and administrator, Local 1776 expanded to over 24,000 members in 1990. A decade earlier, the Retail Clerks International Association had merged with the Amalgamate Meat cutters to create the United Food & Commercial Workers (UFCW) International Union. This is where UFCW Local 1776's name is derived.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/UFCW_Local_1776
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/United_Food_and_Commercial_Workers
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SIOUX CITY -- The United Food and Commercial Workers International Union has taken control of UFCW Local 222 after the local union president was charged with assaulting a union steward ... ....
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Beneficiaries of the generosity of UFCW Local 293 and JBS this year were ... According to Terry Mostek, who represented UFCW Local 293, this year’s gift was the largest that UFCW Local 293 and JBS have given for their holiday program ... Mostek said it is the 12th year that JBS and UFCW Local 293 has given to the community during the holiday season....
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35 UFCW-made Thanksgiving staples
UFCW members make and sell almost all the necessities for a holiday feast, and often work long holiday hours away from their own families to make the holiday happen for others. As you enjoy the following foods this holiday season, take a moment to remember the UFCW members who ......
A career,' says Kelly ... So when the UFCW offered me a chance to start a 2 year program to become a certified butcher, it was an incredible opportunity and I didn't hesitate.' ... UFCW - United Food and Commercial Workers International Union published this content on 16 November 2018 and is solely responsible for the information contained herein ... (noodl....
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This place has come WAY down. - Review of Clyde's At Mark Center, Alexandria, VA - TripAdvisor
This place has come WAY down. - Clyde's At Mark Center
“This place has come WAY down.”
Ranked #12 of 767 Restaurants in Alexandria
This place has come WAY down.
Tonight I dined at the bar in Clyde's at Mark Center. This restaurant used to be quite nice, but obviously it has gone way down hill. I had to send back an appetizer because, although not supposed to be spicy at all, it tasted strongly of red pepper -- far too spicy for my ability to eat. The bartender brought the half-eaten food item back from the kitchen and actually argued with me that the chef denied putting any red pepper in the item. I was not hostile at all, I just physically could not eat the food because it was overwhelmingly spicy hot. The kitchen actually sent the partially eaten food back to me with instructions to eat it anyway. What a disappointment.
Ask RacingMars about Clyde's At Mark Center
1 Thank RacingMars
All reviews brunch crab cakes coffee cake lobster turkey burger oysters on the half shell salad eggs benedict bread burgers potatoes duck fries adirondack room monthly specials clyde's restaurants staying at the hilton
I had my 50th birthday Party there in the back room and also the patio and I must say that it was more than I expected. From the first beginning planning with Arvind he was just so accomodating he chose a great menue that my guest are still raving about. The atmosphere was exactly what I wanted I just cant say enough!! I will end it with this Clyde's at Mark Center you made turning 50 FABULOUS!!! I felt like Cinderella! THANK YOU, THANK YOU!!! I have recommended your restaurant to every body I know. Will definitely be back!
Ask pdogg60 about Clyde's At Mark Center
Thank pdogg60
After a long day at a conference we went to Clyde's at Mark Center for dinner. This restaurant has a great atmosphere. Very warm and inviting. This location has somewhat of a lodge feel with lots of wood and outdoorsy type decor.
The service was expedient and efficient, friendly and unobtrusive. I ordered the Grilled NY Strip Steak roast red bliss potatoes, sautéed spinach and anchovy herb butter 8 ounce strip for 16.95 cooked medium. The steak was cooked perfectly and had only a small bit of gristle, but do note that the anchovy herb butter may make you think that the steak was cooked in fish oil. it was very good, but forgetting that it was anchovy herb butter and not just herb butter, I kept wondering why my steak tasted fishy. That said, I ate every bite. The spinach was delicious. The chef was wise to keep the potatoes simple, with the flavor of the herb butter, a seasoned potato would have been too much.
I also had the Cream of Crab Soup (4.95 cup). Highly recommended. Next time I'll get the bowl (6.00).
My dinner companions had the Chicken Farfalle roast wild mushrooms, spinach, shallots, thyme, sherry cream sauce and goat cheese for 13.95 and the Turkey Chili onions, cheddar cheese, sour cream and cornbread for 10.95. Both were very large portions so you will not leave hungry. Both said their meals were wonderful and would order them again.
For dessert we shared an Apple Crisp baked Gala apples with a crunchy oatmeal topping and vanilla ice cream for 7.95. Save room, this was delicious. A second scoop of ice cream would have been nice, but this was really wonderful and was perfect on a cold, snowy night.
I didn't want to leave the comfort of the hotel after a very long day of travel that began at 4:30 a.m. followed by a full day of meetings, but I'm so glad I was "forced" to go to Clyde's for dinner and would definitely go again.
Ask The_Inside_Skinny about Clyde's At Mark Center
Clydes in located less than 1/2 mile from the Hilton Mark Center Alexandra. It was offered as an alternative to the hotel restaurant by the hotel staff. It was a neat place with pretty good food. The service was pleasant and the prices fair. The desserts were very good and are worth saving a little space for.
Ask kjmcc0729 about Clyde's At Mark Center
We stumbled across Clyde's while staying at the Hilton Mark Center and couldn't have wished for anything better, especially as it was within walking distance of the hotel. We loved everything about it....decor, food, service, all excellent! We had a thoroughly enjoyable experience at Clyde's.
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Patent US6568818 - Three dimensional real image system - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsAn improved optical apparatus and system for producing a three-dimensional real image of an object. The apparatus includes a support member, a first concave reflective surface affixed to the support member and having an associated focal length, and a second concave reflective surface affixed to the support...http://www.google.com/patents/US6568818?utm_source=gb-gplus-sharePatent US6568818 - Three dimensional real image systemAdvanced Patent SearchPublication numberUS6568818 B2Publication typeGrantApplication numberUS 09/275,167Publication dateMay 27, 2003Filing dateMar 24, 1999Priority dateMar 24, 1999Fee statusLapsedAlso published asUS20010036025Publication number09275167, 275167, US 6568818 B2, US 6568818B2, US-B2-6568818, US6568818 B2, US6568818B2InventorsRoger W. Holden, Robert A. BabcockOriginal Assignee21stCentury Sound and Vision, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (2), Referenced by (5), Classifications (11), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetThree dimensional real image system
US 6568818 B2Abstract
What is claimed is: 1. An optical apparatus for producing a three-dimensional real image of an object, the apparatus comprising:
a support member; a first concave reflective surface affixed to the support member and having an associated focal length; and a second concave reflective surface affixed to the support member, wherein the first concave reflective surface and the second concave reflective surface are in substantially fixed spatial relationship to each other to define an acute angle and such that when the object is appropriately placed further than the focal length of the first concave reflective surface, and a set of light rays propagates from the object to the first concave reflective surface, then to the second concave reflective surface and then converge so that the apparatus produces a 3-dimensional real image of the object. 2. The optical apparatus of claim 1 wherein the support member includes an object base suitable for securely positioning the object.
a support member, a first concave spherical mirror affixed to the support member and having an associated focal length; and a second concave spherical mirror affixed to the support member, wherein the first concave spherical mirror and the second concave spherical mirror are in substantially fixed spatial relationship to each other to define an acute angle and such that when the object is appropriately placed further than the focal length of the first concave spherical mirror, the apparatus produces a three-dimensional real image of the object. 6. The optical apparatus of claim 5 wherein the support member includes an object base suitable for securely positioning the object.
an object; a support member including an object base suitable for securely positioning the object and further including an outer housing, a first concave spherical mirror affixed to the support member and having an associated focal length; a second concave spherical mirror affixed to the support member; and a light source operatively associated with the object, the object base and the first and second spherical mirrors, wherein the first mirror and the second mirror are in substantially fixed spatial relationship to each other to define an acute angle and such that when the object is appropriately placed further than the focal length of the first concave spherical mirror, the apparatus produces a three-dimensional real image of the object and yet the object, the light source, the first mirror and the second mirror are not readily observable by the subject. 9. The optical system of claim 8 wherein the object includes structure for generating light.
a support member; a first concave reflective surface affixed to the support member and having an associated focal length; a second concave reflective surface affixed to the support member; and a display device suitable for generating a display image, the display device operatively associated with the support member and first and second reflective surfaces, wherein the first reflective surface and the second reflective surface are in substantially fixed spatial relationship to each other to define an acute angle and such that when the display device is appropriately placed further than the focal length of the first concave reflective surface, the apparatus produces a real image of the display image. 11. The optical apparatus of claim 10 wherein the display device includes a cathode ray tube.
The system 10 and other alternatives discussed herein produce a very realistic image 12 which is believed to be superior in quality to that of a hologram or other state of the art three-dimensional images. The quality of the image is such that image 12 may appear to be laser and/or computer generated even though in the preferred embodiment the effect is achieved with mirrors. The image effect can be further improved by appropriate use of other graphical elements so as to �frame� image 12 and thereby enhancing the realism and three dimensional quality thereof
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4647966 *Nov 22, 1985Mar 3, 1987The United States Of America As Represented By The Secretary Of The NavyStereoscopic three dimensional large screen liquid crystal displayUS5311357 *Dec 3, 1992May 10, 1994Image Technology AssociatesDevice for the creation of three-dimensional images* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS8210694Jul 3, 2008Jul 3, 2012University Of South FloridaPair of concave mirrors for projecting non-inverted real imagesUS8715079Apr 14, 2012May 6, 2014Wms Gaming, Inc.Curved floating virtual displayUS20120242958 *Mar 25, 2011Sep 27, 2012Steve ZuloffCompact Three-Dimensional Virtual Display SystemEP2068190A1 *Dec 7, 2007Jun 10, 2009Kyung Gun ChoiMultiview and multiangle image reconstruction deviceWO2015021116A1 *Aug 6, 2014Feb 12, 2015Wavien, Inc.Aerial projection display with dual reflectors* Cited by examinerClassifications U.S. Classification359/859, 359/871, 359/858, 359/864, 359/857International ClassificationG09F19/16, G02B27/22Cooperative ClassificationG09F19/16, G02B27/2292European ClassificationG09F19/16, G02B27/22V3Legal EventsDateCodeEventDescriptionJul 17, 2007FPExpired due to failure to pay maintenance feeEffective date: 20070527May 27, 2007LAPSLapse for failure to pay maintenance feesDec 13, 2006REMIMaintenance fee reminder mailedJun 18, 1999ASAssignmentOwner name: 21ST CENTURY SOUND AND VISION, INC., KANSASFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HOLDEN, ROGER W.;BABCOCK, ROBERT A.;REEL/FRAME:010042/0251Effective date: 19990611RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services


text:
Delhi Metro wins civil engineering award | delhi | Hindustan Times
Delhi Metro wins civil engineering award
The Delhi Metro Rail Corporation(DMRC) has won the Outstanding Civil Engineering Project Award for the year 2010 specially for completing various infrastructural projects in record time, an official said today.
Updated: Jul 13, 2010 19:21 IST
The Delhi Metro Rail Corporation(DMRC) has won the Outstanding Civil Engineering Project Award for the year 2010 specially for completing various infrastructural projects in record time, an official said today.The award will be given by the international Asian Civil Engineering Coordinating Council(ACECC). The council works for the promotion and advancement of the science and practice of civil engineering and related professions for sustainable development in the Asian region. The award is given to agencies involved in infrastructural projects that have made exemplary contribution to the progress of civil engineering works. The project taken up by the agency should contribute to the nation where the project is located and they should have impacted on or spread through other Asian nations or ACECC member economies. Work on a 125-km stretch of the Delhi Metro is in progress in Phase II and will be completed before the Oct 3-14 Commonwealth Games. Large sections of this have already been opened for the public.	more from delhi

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Technical Support Specialist Jobs, Employment in New York, NY
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Permalance Media Support Technician
ABC News is seeking a support technician for tier 1 support in our New York editing environment. A Proactive approach to support....
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Respond to telephone calls, emails, and personnel request for technical support. Participate in a a rotating on -call after hours/weekends schedule to provide...
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Provide technical knowledge as input into Standards creation, and update on an ongoing basis as products and technologies evolve....
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Smith, John – Tech Support - Friends Website. This role requires frequent interaction with faculty, staff and students, direct support and interactions with the...
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BBC Surrey - Programmes categorised as Factual: Homes & Gardens, All Programmes The BBC has updated its cookie policy. We use cookies to ensure that we give you the best experience on our website. This includes cookies from third party social media websites if you visit a page which contains embedded content from social media. Such third party cookies may track your use of the BBC website. We and our partners also use cookies to ensure we show you advertising that is relevant to you. If you continue without changing your settings, we'll assume that you are happy to receive all cookies on the BBC website. However, you can change your cookie settings at any time. Continue Change settings Find out more ]]> Accessibility links Skip to content Accessibility Help BBC iD Notifications
Categories: Factual: Homes & Gardens, All Programmes Available now Now and next Podcasts All Programmes Filter by Filter by Gardens Gardening Show available episodes View Programme information More on Radio View all {{/each}}

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text: In addition to an indoor pool, pentahotel Chemnitz provides a spa tub, a sauna, and a fitness center. The hotel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. A computer station is located on site and high-speed wireless Internet access is complimentary. Business-related amenities at this 4-star property consist of a business center and meeting rooms. Event facilities measuring 9892 square feet (919 square meters) include conference space. This business-friendly hotel also offers a terrace, coffee/tea in a common area, and concierge services. Parking is available onsite for a surcharge. 24-hour front desk Number of floors - 6 Bar/lounge Breakfast available (surcharge) Business center Coffee/tea in common areas Newspapers in lobby (surcharge) Concierge services Elevator/lift Express check-in Express check-out Conference space Fitness facilities Dry cleaning/laundry service Computer station Free WiFi Luggage storage Total number of rooms - 226 Laundry facilities Meeting rooms 21 Terrace Restaurant Safe-deposit box at front desk Year Built 1996 Area shuttle (surcharge) Conference space size (feet) - 9892 Conference space size (meters) - 919 Beach towels Self parking (surcharge) Sauna Number of buildings/towers - 1 Steam room Indoor pool Television in common areas Number of meeting rooms - 21 Spa tub Show all hotel amenities

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(Redirected from Ochi Day)
Ohi Day (also spelled Ochi Day, Greek: Επέτειος του «'Οχι»[needs IPA] Epeteios tou "'Ohi", Anniversary of the "No") is celebrated throughout Greece, Cyprus and the Greek communities around the world on October 28 each year, to commemorate the rejection by Greek Prime Minister Ioannis Metaxas (in power from August 4, 1936, until January 29, 1941) of the ultimatum made by Italian dictator Benito Mussolini on October 28, 1940.
This ultimatum, which was presented to Metaxas by the Italian ambassador to Greece, Emanuele Grazzi (fr), on October 28, 1940, at dawn (04:00 am), after a party in the German embassy in Athens, demanded that Greece allow Axis forces to enter Greek territory and occupy certain unspecified "strategic locations" or otherwise face war. It was allegedly answered with a single laconic word: όχι (No!) However, his actual reply was, Alors, c'est la guerre (Then it is war).[citation needed]

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text: Toys > Refine Price $ to $ Go Top brands FurReal Store availability Sort Best sellers Price: low to high Price: high to low Highest rating New $64.95 FurReal Friends Pom Pom My Baby Panda Pet 4.5 stars (109) ratings Sold & Shipped by The Toy Ninja Free shipping $36.29 FurReal Friends Pax, My Poopin' Pup 4.0 stars (65) ratings Sold & Shipped by STL PRO, Inc. Free shipping $79.99 FurReal Friends Get Up & GoGo My Walkin' Pup Pet 4.5 stars (193) ratings Sold & Shipped by Imagine Toys! Free shipping $55.79 FurReal Friends Roarin' My Bouncin' Lion Sold & Shipped by The Primrose Lane LLC Free shipping $25.99 FurReal Friends Furry Frenzies FurrStarrs On Tour! Starring Captain Crash Sold & Shipped by OO Free shipping $17.42 FurReal Friends Luvimals Asst Sold & Shipped by Shippped Free shipping 1 Showing 6 of 6 results Departments Learning Toys Dolls & Dollhouses Electronics for Kids Shipping & Pickup Show all Ship to Home Age 0 to 12 Months 12 to 24 Months 2 to 4 Years 5 to 7 Years 12 Years & Up Brand FurReal Category Robots & Robotic Pets Other Dolls & Soft Toys Character Frozen Paw Patrol Disney Princess Minnie Mouse Barbie Teenage Mutant Ninja Turtles Doc McStuffins Spider-Man My Little Pony Thomas & Friends Batman Minions Avengers Captain America Hot Wheels Marvel Super Heroes SpongeBob SquarePants DC Comics Crayola Iron Man See more characters Gender Boys Girls Price $ to $ Go $0 - $10 $10 - $15 $15 - $20 $20 - $25 $25 - $50 $50 - $75 $75+ Retailer Imagine Toys! The Toy Ninja OO STL PRO, Inc. Shippped The Primrose Lane LLC Customer Rating 4.0 stars & Up Material Plastic Other Color Multi Beige Other See more colors Popular in Toys LEGO City Police LEGO Marvel Sets LEGO Ninjago Sets Transformers Toys LEGO Super Heroes the Batcave LEGO City Mine LEGO Ninjago Games Thomas the Train Bedding Compute- app-11031821-31-169923820, DC- prod-dal3, ENV- prod-a, Ver- 52.0.0, SHA- def6a509fddd8ddb1b4a25836de00593f17abd2d, Log- dcf93453-8dbdf-159a85d6e1c000 Site Information Be the first to save! Email Address Sign up Privacy Policy Stay connected Mobile apps Help Feedback MoneyCenter Privacy & Security CA Privacy Rights Terms of Use Walmart services See All Services Walmart MoneyCenter Walmart Credit Card Product Care Plans Walmart Pay Get to know us About Walmart.com Corporate Suppliers Marketplace Careers @WalmartLabs Walmart.com Terms of Use About Our Ads Affiliate Program CA Privacy Rights Privacy & Security Customer service Returns Policy Product Recalls Int’l Customers Tax Exempt Program Contact Us Feedback Store Pickup In the spotlight Expand Toys Kid's Bikes NERF Blasters LEGO Dolls Doll Houses Drones Games Action Figures Expand Electronic Gifts iPads iPhones Video Games Laptops Tablets 4K TVs Digital Cameras Prepaid Phones Expand Gifts for Home Mattresses Air Mattresses Keurig Microwaves Heaters Electric Fireplaces Turkey Fryers Kitchen Appliances Hunting Gear Expand Cold Weather Gifts Women's Jackets Men's Jackets Women's Boots Men's Boots Scarves Hats Shoes Pajamas Lingerie Hunting Clothes Expand International Sites Argentina Brazil Chile China Japan Mexico United Kingdom Popular Products © Walmart Stores, Inc. To ensure we’re able to help you as best we can, please include your reference number: Ref:

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Lindsay Lohan's fury as reality show producers refuse to pay advance | Daily Mail Online
11:21 EST, 17 March 2014
You might consider her lucky to be working at all.But in scenes from her new docu-series Lindsay Lohan was seen attacking producers after they refused to pay her in advance.And the conflict almost cost her the lease on a new apartment.Craig Pilgrim, of the Pilgrim production company shooting the Lindsay show for OWN, was seen pulling a check over fears Lohan would not complete filming.Scroll down for video Fury: Lindsay Lohan reacts with outrage as she learns her production company is stalling on paying her an advance for her half-filmed reality show
'You and I have to have a better understanding because this is making me very frustrated,' he told her on Sunday night's show.'When you tell our production what you will and won’t do, it doesn’t work for me.'But Lohan defended herself, saying: 'I never once said I’m not shooting it.' Row: Craig Pilgrim, of the Pilgrim production company shooting the Lindsay show for OWN, pulled a check over fears Lohan would not complete filming
And she argued: I was ready.'You can’t pull that s*** with me anymore. I am giving you no reason to feel that.'So until I f*** up, you can’t assume I am GOING to!'Eventually the argument was sorted, with Lohan's advance going straight to the owners of her new apartment.It allowed her to move out of the hotel room she had lived in since rehab, which had become cluttered with boxes of her belongings. Dream home: But Lohan almost missed out on renting an apartment when her threatened bad behaviour on set upset producers Moving on: Lohan explained ¿It was such a relief to get the keys and finally have a place I can come home to'	‘It was such a relief to get the keys and finally have a place I can come home to,’ she said.Her friend Sam Mayer and driver Steven Rodriguez came to congratulate her. ‘It was affecting my mental state, being in that [hotel] room, with all that clutter. It was hard,’ she said.Lohan discussed the issues with her father Michael Lohan over a pizza dinner. Boxing it out: Lohan is seen fighting her demons in a scene from the show
And the 27-year-old also too the chance to berate her father - commanding him not to mention her half-siblings in her company.The bitter row ensued because Lindsay wanted her father, Michael Lohan, to buy a car for her younger brother Cody, 18.
Lindsay Lohan argues with her father in front of the cameras for her reality TV series
Michael is a father of six. He has four offspring with Lindsay’s mother Dina Lohan and two from other women. One of his younger daughters, Ashley, was born while he was still married to Lindsay’s mother, the second, a boy, is just one-year-old.Looking decidedly uncomfortable Michael refuted buying Cody the car, siting his obligations to Lindsay’s sister Ali and his youngest children.‘I have child support…that’s supposed to be for the kids,’ he protested.
‘I do not want to talk about your two other to random f***ing kids,’ she snapped.‘Out of all of us Cody’s the one that deserves something the most,’ she told her father.‘It hurts me to see him not getting something that all his friends are getting…he doesn’t have a dad to take him to soccer games…he needs his father,’ she choked. Lindsay Lohan gives a glimpse into her chaotic life on the premiere of her new reality show
‘Your mother cut me out of his life,’ jibed back Michael, now 53, who had a tumultuous separation from Dina, a former dancer.The
argument was part of the second episode of the docuseries Lindsay on Oprah Winfrey’s OWN network. The first of which drew almost 700,000 viewers last week.Reflecting on the incident later the Mean Girls actress said: ‘My dad has this whole other life with all these other people that he’s created…and I do not want to be a part of that.’
‘They are not part of my life and they never will be,’ she confessed.Back
at the restaurant Michael had a fit of insight and wisdom - advising anyone going through a divorce to shield their children from the dispute.‘The kids are the ones that wind up suffering…especially Lindsay…and that wonderful, gifted girl is an example of what can happen,’ he said remorsefully.
Despite obvious tensions Lindsay said her relationship with her father is improving.‘At least we can talk about it now…that’s good,’ she said.Michael was still unwilling to buy the car: ‘But Cody wants a $48,000 car and he wants it now,’ he sighed.In a bid to change the subject Michael attempted to quiz Lindsay about her ‘new boyfriend’ American footballer Matt Nordgren.
Sorting through it all: Lindsay pictured in last weeks episode‘I don’t want to talk about that,’ she said bluntly.‘What? You finally meet a good guy and you won’t tell me about him?’‘He is a good guy,’ she said dismissively.When Michael questioned her about his previous circle of friends she became defensive.‘He was with a different crew then…they were…like idiots,’ she mumbled under the duress.‘Like the kind of idiots that you’re around? Like Gavin?’ said Michael, referring to Lindsay’s stalwart party crony Gavin Doyle.
Meanwhile Lindsay denied that she has partied with Gavin since rehab – claiming they were just having dinner.‘I know the truth, I know nothing is wrong, I know I’m just going to f****** dinner and coming home,’ she grumbled.Clearly annoyed Lindsay then rebuked her father for badmouthing her friends on camera.‘Don’t start doing that, don’t do that on this,’ she barked nodding in the direction of the film crew.‘It p****** me off when you do that, that’s disrespectful, don’t start naming names…’‘You want me to start naming names?’ She threatened.‘You do that, you name names. It's wrong,’ she accused.
‘Why? Because I mention the people in your life that weren't good to you?’ Michael asked.Riled
further she retorted: ‘Because they're people that you don't think were
good for people. See, now you're getting me angry - because you weren't
good for me for a long time in my life!’He replied: ‘Well, if that's what you believe, that's fine, honey, I accept that though. I totally accept that.’
Off camera Lindsay explained her frustrations about her father who would often ‘disappear’ for days on end: ‘So my dad makes a nasty comment about my friends, it hurts me,’
she said.‘They're at places in their lives, as long as they're not bringing that into my life
now, then it's fine to have them in my life.‘They
may go out and do what they want to do but they're not the kind of people who are going to do it around me, and that's what matters to me,’
she said, presumably referring to the hedonistic partying she needs to stay clear from.‘They're good people,’ she continued.
Allegations: TMZ claims the pair were involved in a 'nasty argument' where she is alleged to have hit him several times
‘They've been there for me when I didn't have other people that were, you know, when other people weren't,’ she trailed off.The drama was occurring while Lindsay, fresh out of rehab, was hoping to move into a new apartment in New York City.She was also trying to support her mother, who had just been arrested for an alleged DUI.‘It’s really out of character for her, she’s really ashamed about it,’ said the troubled star.
Big Apple living: The star has been residing in New York as she films the series
‘So I just want to be there for her as much as I can,’ added the actress, who was living in a hotel for 49 days before her apartment finally came through.The show also documented Lindsay’s relationship with the paparazzi.‘Lindsay’s story is an interesting one, I’ve been seeing her out here for ten odd years,’ said NY Paparazzo Philip Vaughan.‘She used to be sweet, friendly and untainted by fame but clearly you look at her now and she’s a completely different person,’ he added.‘You’d expect that, it’s been a decade, but they are their own worst enemies…they keep on failing and every time they fail there is a new reason to chase them,’ he said dryly.In a bid to relieve her stress Lindsay met with AJ Johnson, a professional life coach and trainer.AJ began by asking Lohan a series of quick-fire questions such as: ‘Pool or ocean? black or white? Love or be loved?’When it came to the simple: ‘Yes or no?’ Lindsay hesitated.‘No,’ she answered with a smile, wryly referring to her newfound abstinence.The Two and a Half Men actress then embarked on a health and fitness regime with her new coach.‘Often I know what I’m doing is wrong but I go ahead and do it anyway,’ lamented the star, who was still smoking regularly.‘I used to sabotage things as soon as they started getting good,’ she admitted. Agree to disagree: Lohan does not want to meet her father's children from his other relationships

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Capture of Le Sars - Wikipedia
Capture of Le Sars
50°04′18″N 02°46′53″E / 50.07167°N 2.78139°E / 50.07167; 2.78139Coordinates: 50°04′18″N 02°46′53″E / 50.07167°N 2.78139°E / 50.07167; 2.78139
23rd Division 4th Ersatz Division
737 528 taken prisoner
Le Sars in the region of Nord-Pas-de-Calais and the department of Pas-de-Calais
Le Sars is a commune in the Pas-de-Calais department in the Nord-Pas-de-Calais region of France. The village lies along the Albert–Bapaume road. The village is situated 16 mi (26 km) south of Arras, at the junction of the D 11 and the D 929 roads. Courcelette lies to the south, Pys and Miraumont to the north-west, Eaucourt l'Abbaye to the south-east, the Butte de Warlencourt is to the north-east and Destremont Farm is south-west.
Military operations began in the area in September 1914 during the Race to the Sea, when the divisions of the II Bavarian Corps advanced westwards on the north bank of the Somme, passing through Le Sars towards Albert and Amiens. The village became a backwater until 1916, when the British and French began the Battle of the Somme (1 July – 13 November) and was the site of several air operations by the Royal Flying Corps, which attacked German supply dumps in the vicinity. During the Battle of Flers–Courcelette (15–22 September), the British Fourth Army advanced close to the village and operations to capture it began on 1 October. The village was overrun by the 23rd Division on 7 October, during the Battle of Le Transloy (1 October – 5 November), several hundred prisoners being taken from the [[4th Ersatz Division (German Empire)|4th Ersatz Division]].
After the village was captured, the crest of the rise to the east became the limit of the British advance. In the winter of 1916–1917, which was the worst for fifty years, the area was considered by the troops of the I Anzac Corps to be the foulest sector of the Somme front. The village was lost in March 1918 and recaptured for the last time in August by the 21st Division.
1.2.1 1–3 October
3.2 8 October
Troops of the 4th Bavarian Division reached Le Sars on 27 September, during the Battle of Albert (25–29 September 1914) and advanced on Bazentin le Petit and Longueval where the advance was stopped by French troops attacking eastwards from Albert. The 26th Württemburg Reserve Division advanced through Le Sars during the night of 27/28 September 28th Baden Reserve Division advanced on the south side of the Bapaume–Albert road, through the village towards Fricourt on 28 September.[1]
On 9 July, 21 Squadron, Royal Flying Corps (RFC) bombed supply dumps at Le Sars. A flight of F.E.2b fighters of 22 Squadron escorting artillery observation and contact patrol aircraft on 15 July, attacked ground targets. One aircraft chased German soldiers down the Flers–Le Sars road and then attacked some cavalry hiding under trees and scattered them.[2] On 21 July, a 4 Squadron reconnaissance crew reported new entrenchments around the village.[3] Squadrons of the 15th Wing managed to attack Le Sars several times at the end of July and in August the III Brigade made several attacks on the village. On 27 August, air observers watched as infantry patrols probed towards Le Sars and made many low-flying attacks on German troops opposite the Fourth Army front.[4]
During an attack by III Corps in the Battle of Le Transloy, two battalions of the 7th Brigade of the 23rd Division attacked Destremont Farm and captured Flers Trench and part of Flers Support. Touch was gained with the 151st Brigade of the 50th Division on the right flank. On the north side of the Bapaume road, a long bombing fight eventually forced back the Germans in Flers Trench and touch was gained on the left flank with the 2nd Canadian Division. Patrols probed towards Le Sars, watched by the aviators of 34 Squadron and 3 Squadron but the parties were driven back by small-arms fire from the houses; the captured positions further back were consolidated. Rain began to fall around noon on 2 October and continued for two days, turning the ground to mud. The 50th Division was relieved by the 68th Brigade of the 23rd Division and opposite Le Sars, the 69th Brigade took over from the 70th Brigade. The 69th Brigade tried to bomb up Flers Support on the north side of the Bapaume road. The German 7th Division west of the Bapaume road and the right of the 6th Bavarian Reserve Division in Le Sars, were relieved by the 4th Ersatz Division on 3 October.[5]
Two preliminary operations were conducted by the 69th Brigade, to capture the remaining length of Flers Support Trench and part of Flers Trench just south of the Bapaume road, which had been recaptured by a German counter-attack. Late on 3 October, two companies attacked Flers Support north of the main road and a party began a bombing attack on the recaptured part of Flers Trench at the same time. The attack on Flers Support had to over a distance of 100 yd (91 m) but the mud slowed progress and massed German machine-gun fire caused many casualties. The companies reached the German wire but could get no further. The bombing attack on Flers Trench succeeded but German artillery fire the next day, demolished the strong point and the party was withdrawn. Both attacks were costly failures, the attack on Flers Support leading to 139 casualties and the bombing attack another sixty losses.[6] On 6 October, the Tangle, a maze of trenches east of Le Sars, was attacked by the 11th Northumberland Fusiliers from the 68th Brigade but the troops were later withdrawn, due to the extent of German return fire. The weather began to improve on 4 October but high winds and low cloud made air observation difficult.[7] The rain stopped on 5 October and next day the ground rapidly dried. German artillery-fire on the area was continuous and the opposing lines were very close together, leading to six Germans being captured early on 6 October, who gave information which confirmed the results of gleanings from a German signal lamp, which were read by a German-speaker.[8]
Le Sars and vicinity, October 1916
The 23rd Division had been ordered to attack Le Sars, in combination with an attack by the 47th Division on the Butte de Warlencourt but constant rain on the churned up ground, led postponements of the 23rd Division attack until 7 October.[9] The 23rd Division took over the front of the 50th Division front on 3 October, which gave the division a frontage of 1,000 yd (910 m) south of the Bapaume road and 400 yd (370 m) on the north side. Flers Support was held for 1,000 yd (910 m) on the right and in the centre to a point just south of the road. The division was to take the village and another 800 yd (730 m) of the Flers trenches on the left flank, the 2nd Canadian Division co-operating with the attacks on the trenches. (A postponement of the Canadian attack led to this part of the attack being put back to 8 October.) The village was built along the Albert–Bapaume road and most of the divisional front crossed the road at a right angle until 500 yd (460 m) from the right flank of the divisional front where the Flers trenches dog-legged to the east. An attack on the left would move parallel to the main road and an advance on the right would converge towards the north end of the village. In front of Le Sars on the right flank were two obstacles, a maze of trenches known as the Tangle and a sunken road leading from the west into the village. An advance from this flank would also be vulnerable to enfilade fire from the south end of the village.[10]
Battalions from the 68th and 69th brigades were to conduct the attack, in which the right-hand battalion of each brigade was to attack first. In the first phase, the 12th Durham Light Infantry (DLI) of the 68th Brigade was to capture the tangle and the sunken road. The 9th Green Howards of the 69th Brigade was to capture the village up to the central crossroads. In the second phase, the 13th DLI were to advance in the centre and take the north end of the village and the 11th West Yorkshire would advance twenty minutes after zero hour and take Flers Support on the north side of the road. Artillery support was to come from the 23rd, 50th and 47th divisional artilleries; after the preliminary bombardment a creeping barrage by 18-pounder field guns was to begin 400 yd (370 m) in front of the jumping off lines and move forward at 50 yd (46 m) per minute. A flanking barrage was arranged for the 11th West Yorkshire attack on Flers Support. A machine-gun barrage, Stokes mortar bombardment and tank support were also arranged.[11]
See also: Attacks on the Butte de Warlencourt
1–8 October 1916[12]
On 7 October, German aircraft appeared over British artillery positions from Guedecourt to Flers and directed artillery fire onto the British batteries; the fighter pilots of IV Brigade found that the German aircraft had gone by the time that they arrived.[a] Contact patrol pilots found that the westerly wind was so strong that they had to turn into the wind, for the observers to study the ground, which made them nearly stationary and easy targets for infantry ground fire. Two crew were wounded and many of the aircraft were damaged.[14] At 1:45 p.m., zero hour for the Fourth Army attack, the 12th DLI of the 68th Brigade attacked on the right flank, in four waves, behind a tank. The tank had arrived a minute after zero and cleared the Tangle of German defenders, before it was occupied by the infantry. When the tank turned left at the sunken Eaucourt l'Abbaye–Le Sars road, it was knocked out by a shell. The infantry came under machine-gun fire from the road and crossfire from machine-guns in Le Sars and from the right flank; the battalion formed a defensive flank from the tangle to the right of British front line. The 9th Green Howards of the 69th Brigade had advanced on the left flank at the same time and entered Le Sars close behind the barrage, heading for the first objective at the crossroads in the village.[15]
The German garrison was surprised and many soldiers were killed as they tried to man machine-guns but the Germans recovered quickly and managed to slow the British advance along the village. An unduly negative report of the progress of the battalion was given to a patrol of the 13th DLI, which had gone forward early to maintain liaison. The commander of the 13th DLI sent a company to attack the crossroads from the south, with a second company in support. The first company advanced in two waves that were stopped by German machine-gun fire; the second wave halted on the same line and engaged the Germans with rifle-fire and hand grenades. The supporting company came up and the attack restarted, meeting the 9th Green Howards at the crossroads, having killed or captured about 100 German troops. On the right the 12th DLI saw that the Germans in the sunken road had been outflanked, rushed the road and took possession. Twenty minutes after zero, the 11th West Yorkshire formed two companies in Flers Trench and two in Destremont Farm. The foremost and rearmost lines were struck by massed machine-gun fire from the front and the left flank and by artillery-fire. The two companies advancing from Destremont Farm lost all but 32 men and the attack failed.[16]
A bombing attack up Flers Trench which had begun at the same time, advanced for 50 yd (46 m) and captured the heads of two communication trenches to Flers Support. Bombing attacks up the communication trenches to Flers Support were met by determined German resistance and stopped. A company of the 10th Duke of Wellington's Regiment (10th Duke's) reinforced the 11th West Yorkshire. The 9th Green Howards in the village had consolidated and arranged a combined attack north of the village on Flers Support.[17] The German defence collapsed as soon as the third attack began and the German infantry hid or ran back from Flers Support. The Germans were engaged by artillery, machine-guns and rifle-fire and most were killed, a Lewis gunner in the village crossroads shooting down 70–80 men. A captured corporal was made to gain the surrender of survivors and more than 100 Germans gave up, as did another sixty stragglers. The 11th West Yorkshire were severely depleted and another two companies of the 10th Duke's were sent forward to help consolidate the 69th Brigade objectives.[18]
In the centre the 13th DLI was to advance through the Green Howards and capture the rest of the village. The companies of the 13th DLI and the Green Howards in the village left a platoon at the crossroads, to dig in and gain touch with the 12th DLI on the right and posted bombers at dug out entrances. Little resistance was met and the north end of the village was occupied. At 3:40 p.m. a third 13th DLI company advanced and joined the force in the village, to help dig strong points beyond the village to cover the avenues of attack from the east and north-east.[18] The 12th DLI had dug in along the sunken road beyond the Tangle and pushed out advanced posts on the right flank. The 13th DLI and the Green Howards consolidated the village and linked the new posts beyond the northern fringe, to the 12th DLI posts by 7:50 p.m.; a request was made for two tanks and two companies to attack the Butte de Warlencourt from the west, after patrols had found the area to be unoccupied but no troops were available.[15] Touch had not been gained with the 69th Brigade troops north-west of the village and a company of the 11th Northumberland Fusiliers with two machine-guns went forward after dark.[19]
See also: Capture of Regina Trench
The 23rd Division infantry and engineers spent the night consolidating the Le Sars defences and preparing for the attack with the Canadians, which had been postponed to 8 October. Two battalions formed carrying parties and two more cleared out 26th Avenue, the only communication trench in the area. The delayed 69th Brigade attack on Flers Trench and Flers Support to the north of the village was prepared overnight. To meet the attack of the 2nd Canadian Division and to capture a quarry behind the German trenches, two companies of the 8th York and Lancaster Regiment (8th York and Lancs), which had been attached to the 69th Brigade, took over on the divisional left flank during the night. Each company had a Stokes mortar and the Flers trenches were bombarded all night by the 23rd Division artillery. The Canadian attack on Regina trench began at 4:50 a.m. and the York and Lancs companies began to bomb along the trenches as soon as the barrage lifted. The attack succeeded swiftly and fifty prisoners and three machine-guns were captured, touch was gained with the Canadians and the quarry reconnoitred. It was found to be overlooked from German positions so a post was dug nearby in sheltered ground to overlook the area. A German counter-attack forced back the Canadians, leaving the 23rd Division flank open but no attack followed.[20]
The high winds and the lack of observation in the preceding days due to rain, reduced the accuracy of the British artillery and the presence of German aircraft, which correspondingly increased the accuracy of German defensive barrages, contributed to the failure of the infantry to reach their objectives, except at Le Sars and beyond Gueudecourt.[14] The 47th Division attack on the Butte de Warlencourt succeeded on the right flank but failed to capture the butte, which was on the left flank. The 23rd Division had captured all its objectives and credited the artillery support for the success of the attacks, along with the efforts of the troops on the lines of communication, who from 2 to 8 October endured constant shelling. Telephone lines were frequently cut by the German artillery-fire but the brigade headquarters were rarely out of touch with the battalions for many minutes. Runners from battalion headquarters to the front, crossed ground under severe bombardment yet rarely delivered messages late. The initiative of the battalion commanders and the co-ordination of units, so that the 13th DLI immediately reinforced the Green Howards and the discretion of the 12th DLI in waiting at the tangle were commended.[21]
The 23rd Division had 627 or 737 casualties according to either the divisional or the 68th Brigade records; the division took 528 prisoners.[22]
After the capture of Le Sars, the crest of the rise to the east, over which the spires of Bapaume could be glimpsed in clear weather, became the limit of the British advance.[23] During the winter of 1916–1917, which was the worst for fifty years, the area was considered by the troops of the I Anzac Corps to be the foulest sector of the Somme front. The village was lost on 25 March 1918 during Operation Michael.[24] Le Sars was recaptured for the last time on 25 August by the 21st Division, during the Second Battle of Bapaume (21 August – 1 September).[25]
^ From 30 January 1916, each British army had a Royal Flying Corps brigade attached, which was divided into wings, the corps wing with squadrons responsible for close reconnaissance, photography and artillery observation on the front of each army corps and an army wing, which controlled the fighter squadrons and conducted long-range reconnaissance and bombing, using the aircraft types with the highest performance.[13]
^ Whitehead 2010, pp. 30–33; Sheldon 2005, pp. 26, 28.
^ Jones 2002, pp. 230–231.
^ Gliddon 1987, p. 262.
^ Jones 2002, pp. 252, 258, 295.
^ Sandilands 2003, pp. 109–110.
^ Miles 1992, pp. 431–432, 434.
^ Sandilands 2003, pp. 111–112.
^ Sandilands 2003, p. 109.
^ Sandilands 2003, pp. 110–111.
^ Sandilands 2003, p. 111.
^ a b Miles 1992, p. 437.
^ Sandilands 2003, pp. 112–113.
^ Sandilands 2003, pp. 112–114.
^ a b Sandilands 2003, p. 115.
^ Sandilands 2003, pp. 115–116.
^ Nicholson 1962, pp. 184–187; Sandilands 2003, pp. 116–117.
^ Sandilands 2003, pp. 116–120.
^ Sandilands 2003, p. 117.
^ Stewart & Buchan 2003, p. 87.
^ Edmonds, Davies & Maxwell-Hyslop 1995, p. 479.
^ Edmonds 1993, p. 269.
Edmonds, J. E.; Davies, H. R.; Maxwell-Hyslop, R. G. B. (1995) [1935]. Military Operations France and Belgium 1918: The German March Offensive and its Preliminaries. History of the Great War Based on Official Documents by Direction of the Historical Section of the Committee of Imperial Defence. I (Imperial War Museum and Battery Press ed.). London: Macmillan. ISBN 978-0-89839-219-7.
Miles, W. (1992) [1938]. Military Operations in France and Belgium: 2 July to the End of the Battles of the Somme. History of the Great War Based on Official Documents by Direction of the Historical Section of the Committee of Imperial Defence. II (Imperial War Museum and Battery Press 1992 ed.). London: Macmillan. ISBN 978-0-89839-169-5.
Nicholson, G. W. L. (1962). Canadian Expeditionary Force 1914–1919 (PDF). Official History of the Canadian Army in the First World War. Ottawa: Queen's Printer and Controller of Stationary. OCLC 557523890. Retrieved 22 September 2014.
Sheldon, J. (2005). The German Army on the Somme. Barnsley: Pen & Sword. ISBN 978-1-84415-269-8.
Whitehead, R. J. (2013) [2010]. The Other Side of the Wire: With the German XIV Reserve Corps, September 1914 – June 1916. I (pbk. ed.). Solihull: Helion. ISBN 978-1-908916-89-1.
Maude, A. H., ed. (1922). The History of the 47th (London) Division 1914–1919 (online ed.). London: Amalgamated Press. OCLC 6029656. Retrieved 21 September 2014.
Snowden, K. L. (2001). British 21st Infantry Division on the Western Front 1914–1918: A Case Study in Tactical Evolution (PDF) (PhD). Department of Modern History School of Historical Studies: Birmingham University. OCLC 690664905. Retrieved 30 September 2013.
Wikimedia Commons has media related to Capture of Le Sars.
Map: Le Sars to Bapaume
Website showing vicinity of Le Sars
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Harnessing the Immune System to Fight Cancer - The New York Times
Health|Harnessing the Immune System to Fight Cancer
Steve Cara in an examination room at Memorial Sloan Kettering Cancer Center. Mr. Cara learned two years ago that he had advanced lung cancer, but immunotherapy drugs called checkpoint inhibitors have helped wipe out the disease.CreditCreditSam Hodgson for The New York Times
His tumor had shrunk by a third.
By August, more than half of the tumor had vanished. The rash came back, however, and worsened. Steroids worked again, but in October a far more alarming side effect set in: breathing trouble.
“He’s had the best possible response,” Dr. Hellmann said. “I hope that remains permanent. Only time will tell, and I think he’s conscious of that.”
Attacking Cancer Cells
Co-stimulator
T-cells are a type of white blood cell that can identify and kill infected, damaged or cancerous cells. Each T-cell has clawlike receptors on its surface that can recognize and lock onto antigens, foreign or abnormal protein fragments on the surface of infected or cancerous cells.
ACTIVATING A T-CELL
The T-cell must be activated before it can find and attack cancer cells. A specialized cell presents the T-cell with an antigen from a cancer cell, along with a co-stimulator protein. The T-cell begins to hunt down and kill any cells that are covered with the same antigen.
CANCER AND CHECKPOINTS
Cancer cells can avoid destruction by taking advantage of a switch on the T-cell called an immune checkpoint. The checkpoint can shut down the T-cell and suppress the immune response, allowing the cancer to grow undisturbed.
Drugs known as checkpoint inhibitors can physically block the checkpoint, which frees the immune system to attack the cancer. A single T-cell can kill thousands of cancer cells.
Helen Coley Nauts, left, rekindled interest in the work of her father, William B. Coley, right, who is considered the father of cancer immunotherapy. Anton Chekhov, center, the Russian physician and playwright, saw a connection between bacterial infections and cancer remission.CreditLeft to right: Cancer Research Institute, Bettmann, via Getty Images, Cancer Research Institute
Dr. James P. Allison and Dr. Padmanee Sharma have been research collaborators since 2005, and spouses since 2014. Dr. Allison developed Yervoy, the first of the checkpoint inhibitors.CreditIlana Panich-Linsman for The New York Times
The drug the woman on the plane thanked him for was Yervoy, the first of the checkpoint inhibitors. It was approved for advanced melanoma in 2011. Dr. Allison — a scientist, not a physician — has won numerous research awards and is expected by many to win a Nobel Prize. He drives a Porsche convertible with a license plate bearing the name of the checkpoint he deciphered: CTLA-4.
Dr. Allison wondered if it might be possible to block the checkpoint and launch the T-cells against cancer. He and a graduate student, Matthew Krummel, developed an antibody — a molecule made by certain cells of the immune system — that would stick to the checkpoint and block it. When the researchers, including Dana Leach, a postdoctoral fellow, gave the antibody to mice with cancer, tumors vanished.
David Wight with his daughter Isabella after a soccer game in Anchorage, Alaska. “I’m very fortunate,” he said.CreditJoshua Corbett for The New York Times
But doctors do not know how long the treatments should continue. They wonder how long the remissions will last, and whether some will even turn out to be cures, Dr. Siefker-Radtke said. Some studies were planned to last just a year or two, longer than the life expectancy of most patients with advanced disease. Researchers did not think they would have to decide whether to keep treating people for years.
An earlier version of this article overstated the initial effect of a new treatment against cancer for the patient, Steve Cara. His tumor had shrunk by a third, not half, at the time of his first scanning in March 2015. By August, more than half, not 90 percent, of the tumor had vanished.
An article last Sunday about immunotherapy misstated the role of a postdoctoral fellow in research on a structure on immune cells known as a checkpoint. The fellow, Dana Leach, was involved in showing that treatment with an antibody to block a checkpoint could lead mice to reject tumors. He was not involved in developing the antibody. (Matthew Krummel, a graduate student at the time, helped develop the antibody.)
A version of this article appears in print on , on Page A1 of the New York edition with the headline: A Sickened Body as Cancer Weapon. Order Reprints | Today’s Paper | Subscribe
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