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Patent US20020109774 - System and method for wide field imaging of body lumens - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA system and method for wide angle imaging of body lumens are provided. The system comprises at least one imager and an optical system having a plurality of optical paths for imaging images from within the body lumen onto the at least one imager. The system may be incorporated in or attached onto a device...http://www.google.com/patents/US20020109774?utm_source=gb-gplus-sharePatent US20020109774 - System and method for wide field imaging of body lumensAdvanced Patent SearchPublication numberUS20020109774 A1Publication typeApplicationApplication numberUS 10/046,541Publication dateAug 15, 2002Filing dateJan 16, 2002Priority dateJan 16, 2001Also published asEP1393567A2, EP1393567A4, EP1393567B1, WO2002054932A2, WO2002054932A3Publication number046541, 10046541, US 2002/0109774 A1, US 2002/109774 A1, US 20020109774 A1, US 20020109774A1, US 2002109774 A1, US 2002109774A1, US-A1-20020109774, US-A1-2002109774, US2002/0109774A1, US2002/109774A1, US20020109774 A1, US20020109774A1, US2002109774 A1, US2002109774A1InventorsGavriel Meron, Arkady GlukhovskyOriginal AssigneeGavriel Meron, Arkady GlukhovskyExport CitationBiBTeX, EndNote, RefManPatent Citations (31), Referenced by (234), Classifications (24), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetSystem and method for wide field imaging of body lumens
BRIEF DESCRIPTION OF THE DRAWINGS [0018] The present invention will be understood and appreciated more rally from the following detailed description taken in conjunction with the appended drawings in which: [0019] [0019]FIG. 1A is a schematic longitudinal cross section view of a device comprising the system comprising a single imager, according to an embodiment of the invention; [0020] [0020]FIG. 1B is a schematic radial cross section view of the device shown in FIG. 1A; [0021] [0021]FIG. 1C is a more detailed view of the imager shown in FIG. 1B; [0022] [0022]FIG. 2A is a schematic longitudinal cross section view of the system comprising five optical paths, according to an embodiment of the invention; [0023] [0023]FIG. 2B is a schematic radial cross section view of the system shown in FIG. 2A; [0024] [0024]FIG. 3 is a schematic presentation of the combing of four images to a single combined image, according to an embodiment of the invention; [0025] [0025]FIG. 4 is a schematic longitudinal cross section view of a device comprising the system that comprises front and rear optical paths, according to an embodiment of the invention; [0026] [0026]FIG. 5 is a schematic radial cross section view of the system comprising a plurality of imagers, according to an embodiment of the invention; [0027] [0027]FIG. 6 is a schematic longitudinal cross section view of a device comprising the system comprising a plurality of optical paths partitioned off from each other, according to an embodiment of the invention; and [0028] [0028]FIG. 7 is a schematic radial cross section view of a device comprising a system that comprises a plurality of optical paths partitioned off from each other, according to an embodiment of the invention. DETAILED DESCRIPTION OF THE INVENTION [0029] The system and method, according to an embodiment of the present invention, enable wide angle imaging of body lumens. The wide angle of view is obtained by imaging partially overlapping or non overlapping portions of the body lumen, using a plurality of optical paths. The images of the body lumen portions may be combined to a single image. [0030] The imaging of different portions of the body lumen, which may or may not be simultaneous, is done by employing a plurality of optical paths, each of which covers a different portion of the body lumen. In accordance with different embodiments of the invention, and as will be shown in the figures, light rays may be collimated through the different optical paths to a single imager or to a plurality of imagers. The different optical paths may or may not be separated from each other by a physical partition. [0031] A separate transmitter and channel of transmission may be assigned to each imager for simultaneous transmitting of signals from the body lumen, [0032] Alternatively, the output of several imagers may be combined over a single transmitter and channel of transmission e.g. by using different carrier frequencies. According to one embodiment, the combination of information from the different imagers over the single channel may be done either by selecting a bit from a different imager each time, thus transmitting all the images almost simultaneously, or by transmitting image after image. [0033] The system according to an embodiment of the invention comprises a plurality of optical paths and at least one imager for endo-luminal imaging. In one embodiment the system may be incorporated in or attached to any device or probe suitable for being inserted into a body lumen, such as at the tip of a needle, on the inserted end of an endoscope or hi a swallowable capsule. In one embodiment the system is positioned behind an optical window. [0034] In the following description, various aspects of the present invention will be described. For purposes of explanation, specific configurations and details are set for in order to provide a thorough understanding of the present invention. However, it will also be apparent to one skilled in the art that the present invention may be practiced without the specific details presented herein. Furthermore, well known features may be omitted or simplified in order not to obscure the present invention. [0035] A swallowable capsule comprising a video camera for imaging the GI tract is described in the above mentioned U.S. Pat. No. 5,604,531 and WO 01/65995. A capsule that may comprise similar elements to the capsules described in U.S. Pat. No. 5,604,531 and WO 01/65995 but that comprises a plurality of optical paths, is schematically shown in FIG. 1. The capsule 10 comprises illumination sources 13, such as light emitting diodes (LEDs), a system 19 including lenses 11 and mirrors 18, all positioned behind optical window 12, an imager 14, such as a CMOS imager for obtaining images from within the GI tract, power source 15, such as a battery, which provides power to the entirety of the electrical elements of the capsule and transmitter 16 and antenna 17 for transmitting video signals from imager 14. Signals may be transmitted using various digital or analog; modulation techniques. For example transmission of a digital image over a radio channel may use an FSK (frequency Shift, Keying) modulation technique. [0036] Externally to the body there is a receiver (not showy) for receiving the signals transferred by transmitter 16 and antenna 17. [0037] Light rays from illumination sources 13 illuminate the GI tract inner wall. Remitted light rays are collected by lenses 11 and 11′ and directed by mirrors 18 and 18′ to imager 14. Lens 11 gathers illumination rays at angle α, obtaining an to image field that is defined by angle α. Lens 11′ gathers illumination rays at angle α1, obtaining an image field that is defined by angle α1. Thus, by using both lenses 11 and 11′, an image field defined by angle (α+α1) can be covered, [0038] Two more optical paths can be situated in parallel to the paths which include lens 11 and mirror 18 and lens 11′ and mirror 18′ so that an image field twice as wide can be covered. In this manner, a wide field in different planes can be imaged, as further shown in FIG. 1B [0039] [0039]FIG. 1B is a schematic radial cross section illustration of a system comprising four optical paths 11, 11′, 11″ and 11′″ in all of which remitted light is directed to a single imager 14. The four fields 101, 101′, 101″ and 101′″. covered by the four optical paths 11, 11′, 11″ and 11 ′″ are imaged onto imager 14 coincidentally. As shown in FIG. 1C each of the fields: 101, 101′, 101″ and 101′″ takes up a quarter of the imager 14 face area (for example, 128�128 pixels of the 256�256 pixels area of the imager), [0040] The optical schemes illustrated in FIGS. 1A and 1B provide a viewing angle that is larger tan 180�, in the longitudinal plane (FIG. 1A) and 360� imaging in a plane perpendicular to the longitudinal plane (FIG. 1B). [0041] Similarly, the system of the invention may comprise five optical paths, as shown in FIG. 2A. FIG. 2A schematically illustrates the system comprising an optical path which includes lens 21 and mirror 28, an optical path which includes lens 21′ and mirror 28′ and an optical path which includes lens 25. Together with a two more optical paths that are situated in parallel to the paths that include lens 21 and mirror 28 and lens 21′ and mirror 28′, there are five optical paths covering a wide image field. [0042] [0042]FIG. 2B is a schematic radial cross section illustration of a system comprising five optical paths (only four optical paths 21, 21′, 21″ and 21′″ are shown) in which remitted light is directed to a single imager 24. The five fields 201, 201′, 201″, 201′″ and 205 covered by the five optical paths are imaged onto imager 24 coincidentally. [0043] The five optical path scheme shown in FIGS. 2A and 2B provides optionally better overlapping between margins of neighboring; optical path fields than the four optical path scheme and thus enables better reconstruction of a single combined image. [0044] The system illustrated in FIGS. 2A and 2B can be incorporated in or attached to device 20 which may be an endoscope, a needle, a stent, a capsule designed to pass through the GI tract, etc. [0045] The components of the system according to an embodiment of the invention may be specifically designed for the system, or the system may utilized some components from other systems that operate in body lumens, thus economically taking advantage of existing components. For example, the system of the invention may be incorporated into or affixed onto medical devices meant for being inserted into body lumens, such as needles, stents, endoscopes or capsules designed to pass through the entire GI tract. For example, endoscopes utilize a light source and sometimes an imaging device while operating. Thus, the system of the invention can be incorporated into an endoscope and utilize the endoscope's light source and imaging device. [0046] Combining multiple images to a single image is schematically shown in FIG. 3. The four different fields 301, 301′, 301″ and 301′″ imaged on imager 34 are combined into a single image 31 which is a wide angle image of the lumen being viewed, The obtained images may be presented separately for a physician's examination, or may be combined and presented as a single wide-angle image. [0047] As shown in FIGS. 1B and 2B there can be an overlap between the fields obtained by the different optical paths. Thus, part of the fields 301, 301′, 301″ and 301′″ may be the same. For example, points A1, A2, A3 and A4 all represent the same pixel, while point B represents a pixel unique to field 301′. [0048] The combination into the single image 31 may be performed, for example, by applying an algorithm which assigns each image point (pixel) in the different fields 301, 301′, 301″ and 301′″ to another point (pixel) of the single image 31 Thus, points A1, A2, A3 and A4 will be assigned to point A in image 31 and point B will be assigned to point B1 in image 31. [0049] The four different fields 301, 301′, 301″ and 301′″ may be combined by a combiner in the receiving system which is adapted to combine a plurality of images into a single image. The operation of combining images into a single image usually requires significant processing effort and computing resources. Therefore this operation is usually performed off-line (after receiving the image transmitted from the imager) in an external recording/processing device (not shown). [0050] Another embodiment of the invention is schematically illustrated in FIG. 4, in which a longitudinal cross section of device 40 is schematically shown. Device 40 comprises two optical domes 42 and 402 behind which are situated illumination sources 43 and 403 and optical paths 41 and 401, respectively. In optical pats 41 and 401 remitted light is directed to imagers 44 and 404 respectively. The device 40 further comprises power source 45, which provides power to the entirety of electrical elements of the device, and transmitter 46 and antenna 47 for transmitting video signals from the imagers 44 and 404. The system of the invention, as operable in device 40, is capable of simultaneously obtaining images of the body lumen, for example, the GI tract, from two ends of the device. For example, device 40 may be a cylindrical capsule having a front end and a rear end, which is capable of passing the entire GI tract. The system in a cylindrical capsule can image the GI tract in the front and in the rear of the capsule. [0051] In one embodiment, device 40 is inserted into a body lumen, for example a patient's GI tract The patient may swallow the device and it will start its journey in the patient's GI tract. Some parts of this journey are through voluminous areas of the GI tract, for example, the stomach or the large intestine, in which the device 40 is not always oriented “head first”, with one end of the device leading and the other end following. In the wider areas of the GI tract the device 40 may tumble in a rotating motion trough the GI tract. In this case, simultaneous imaging of the front and rear of the device 40 is advantageous in imaging a wide field of the lumen, Also, there is an advantage in viewing the same site from different angles (as imaged by the front imager e.g., 44 and by the rear imager e.g., 404), especially, for example, if the site is enclosed in a fold of the GI tract. [0052] Both images obtained by imagers 44 and 404 may be transmitted by transmitter 46 serially or simultaneously, as described above. Optionally, each imager may be assigned a separate transmitter and channel for transmitting the images. The two images (front and rear) can be displayed separately or as a single combined image. [0053] In another embodiment of the invention a plurality of optical paths and a plurality of imagers are employed. The system schematically illustrated in FIG. 5 comprises a plurality of optical paths, for example 52 and 52′ having a plurality of imagers, for example 54 and 54′. In each optical path 52 and 52′, which may include lenses and mirrors for gathering and collimating remitted light, the remitted light is directed to a separate imager 54 and 54′ respectively, such that different portions of the body lumen are imaged on different imagers. Optical paths 52 and 52′ may be situated in capsule 50, which is designed to pass through and image the entire GI tract. [0054] The different images, which may be acquired simultaneously, can be transferred to a receiving system over a single channel or over a multi channel links as described above. [0055] In a single channel fink the concurrently acquired images are transferred serially and a multiplexer may be used to effect transmission. A single channel link operates at a higher frequency than a multi channel link. In a multi channel link the images can be transferred in parallel and at a lower frequency and thus have larger bandwidths. The multi channel link may thus be more suitable for transferring larger amounts of data. Also, the lower frequency multi channel link may be more suitable for use with a capsule 50 designed to pass through and image the entire GI tract in which the frequency used for transmitting images from the GI tract is usually limited to the 200-500 MHz range. [0056] Another embodiment of the invention is schematically illustrated in FIGS. 6 and 7. In FIG. 6 a longitudinal cross section of device 60 is schematically illustrated. Device 60 comprises a plurality of optical paths 62, 62′ and 62″ in which remitted light is directed to imagers 64, 64′ and 64″ respectively, Each optical path and respective imager are partitioned off from the other optical paths and imagers by partitions 601, 602 and 603, and each partitioned optical path has its own illumination source 63, 63′ and 63″. In one embodiment the device 60 comprises an optical dome which may extend over most of the device, covering the optical paths 62, 62′ and 62″, or the device may include an optical dome covering optical path 62′ and optical windows on the sides of the device covering optical paths 62 and 62″. Partitions 601, 602 and 603 may be made of opaque material and may serve to prevent interference between the operation of the different imagers and their associated illumination sources. [0057] A radial cross section of a device comprising a plurality of optical paths partitioned from each other is shown in FIG. 7, The device 70 may be cylindrical shaped, similar to a swallowable capsule or to an endoscope tip, or it may a transparent sphere shaped device or it may be of any shape suitable for being inserted into and passing through a body lumen. [0058] In device 70 each of the imagers 74 faces a portion of the body lumen at 90� to its neighboring imager. The body lumen is illuminated by illumination sources 73 and remitted light is directed onto imager 74 through optical path 72. In this manner a complete 360� field can be imaged. The mechanical dividers, partitions 701, serve to avoid having interference between the different imagers 74 and illumination sources 73 [0059] It will be appreciated by persons skilled in the art that the present invention is not limited by what has been particularly shown and described herein above. Rather the scope of the invention is defined by the claims which follow. 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name: GIVEN IMAGING LTD., ISRAELFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MERON, GAVRIEL;GLUKHOVSKY, ARKADY;REEL/FRAME:012786/0579Effective date: 20020410RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services


text:
Comparison of clinical features and outcomes of hospitalized adult patients with novel influenza A (H1N1) pneumonia and other pneumonia. - PubMed - NCBI
1 selected item: 23570478
Acad Emerg Med. 2013 Jan;20(1):46-53. doi: 10.1111/acem.12062.
Comparison of clinical features and outcomes of hospitalized adult patients with novel influenza A (H1N1) pneumonia and other pneumonia.
Sohn CH1, Ryoo SM, Yoon JY, Seo DW, Lim KS, Kim SH, Hong SB, Lim CM, Koh YS, Kim WY.
The authors conducted a prospective cohort study of consecutive adult (over 15 years old) patients with suspected CAP requiring admission to a tertiary university-affiliated hospital during the second wave of pandemic 2009 H1N1 influenza. Based on the results of real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis, the staff completed a standard assessment form and managed the patients according to a uniform protocol. Clinical characteristics, as well as laboratory and radiologic findings, were collected and compared between pandemic 2009 H1N1 pneumonia and CAP of other origin. The primary outcome was in-hospital mortality and secondary outcomes were duration of hospitalization, duration of intensive care unit (ICU) stay, and requirement of mechanical ventilation.
23570478
10.1111/acem.12062

type: global

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text:
China Mobile International Ltd: Company Profile - Bloomberg
China Mobile International Limited (CMI) provides global telecommunication solutions. The Company delivers services on voice, data, mobile, value added businesses, and internet data center services. CMI serves customers worldwide.
Kowloon Commerce Centre, Tw 1
No 51 Kwai Cheong Road
Phone: 852-3975-6688
Fax: 852-3188-1660
Web url: www.cmi.chinamobile.com

value: This website is an international news agency headquartered in New York City and a division of Bloomberg L.P. Content produced by Bloomberg News is disseminated through Bloomberg Terminals, Bloomberg Television, Bloomberg Radio, Bloomberg Businessweek, Bloomberg Markets, Bloomberg.com, and Bloomberg's mobile platforms. Since 2015, John Micklethwait has served as editor-in-chief.


text:
2 bedroom flat for sale in Hainault Road, Upper Leytonstone, E11, E11
www.rightmove.co.uk/property/62993315
Large Rear Bayed Bedroom
Stunning larger than average two bedroom ground floor flat is set back from the road, with own front door and share of freehold. Situated in sought after turning in Upper Leytonstone with good access to the main shopping area and Central line tube station.
Close to local shops, Epping Forest, Hollow ponds and open fields. Comprising: Entrance via own front door to hallway with built-in cupboards. Large bayed fronted lounge with feature stone fireplace including open stone affect gas fire. Master bedroom with access to rear garden. Beautiful fitted kitchen / diner with integrated washing machine, dishwasher, microwave, coffee machine, round central island with cupboards under, dual range cooker including hot plate and access to garden. Tiled contemporary bathroom suite with heated towel rail. Spacious rear bayed bedroom over looking garden.
Exterior: Shared rear garden, mainly paved, additional decked area to side of property. Shared off street parking to front of property. Large Two Bedroom Ground Floor Flat
Range Cooker With Double Oven & Hot Plate
Built-In Microwave & Coffee Machine
Round Central Island With Cupboards Under
Good Access To Shops, Tube & Fields
To view this media, please visit the on-line version of this page at www.rightmove.co.uk/property-for-sale/property-62993315.html
Property reference ST1736.

value: This website is a UK-based company that runs rightmove.co.uk, the UK's largest online real estate portal and property website. It is listed on the London Stock Exchange and is a constituent of the FTSE 100 Index.


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John Wedgwood (doctor) - Wikipedia
John Wedgwood (doctor)
John Wedgwood CBE (28 September 1919 – 30 August 2007), was until his death the heir presumptive to the barony Wedgwood, as elder son of the second son of the 1st Baron Wedgwood. He was a noted British physician, whose death was commemorated with a long obituary in The Daily Telegraph. His area of specialisation was geriatric medicine and improving conditions for elderly patients
John Wedgwood was the elder son of the Hon. Josiah Wedgwood by his wife the former Dorothy Mary Winser. He was educated at Abbotsholme School and then at Trinity College, Cambridge before going onto Guy's Hospital. He studied surgery but was wounded during the Second World War which left him unable to stand for long periods of time and therefore unable to practice surgery. He switched to general medicine initially specialising in cardiology before becoming interesting in geriatric and disability medicine. In 1987 he was appointed CBE for his work.
He was twice married, and had issue three sons and two daughters by his first wife Margaret Mason whom he married 1943 and divorced 1971. He was also survived by his second wife Jo Tamlyn (née Ripsher) whom he married in 1972.
Antony John Wedgwood (born 31 January 1944)
Judith Margaret Susanna Wedgwood (born 24 August 1946), married firstly Christopher Anthony Wingfield Tracy, of Wimbledon, London SW19, son of David Quinn Wingfield Tracy, of Bickley, co. Kent, and secondly in 1986 (Kevin) Dominic Hall Brennan, and has issue by both husbands.
Simon James Josiah Wedgwood (born 3 October 1949)
Nicholas Ralph Wedgwood (born 30 June 1951)
Katherine Sarah Wedgwood (born 24 November 1955); married 22 April 1988 Ian Reed Stanbury, of Harewood Cottage, Chicksgrove, co. Wiltshire, and has issue.
From 1970, he was the heir presumptive to his nephew, the 4th Baron Wedgwood. His eldest son, Antony John Wedgwood, succeeded as the 5th Baron in January 2014.
John Wedgwood Obituary in The Times, 19 September 2007
John Wedgwood Obituary in the Daily Telegraph 1 September 2007.
Michael Rhodes. Information on Wedgwood succession in Peerage News online discussion group. Posted 3 September 2007. Retrieved 7 September 2007
Retrieved from "https://en.wikipedia.org/w/index.php?title=John_Wedgwood_(doctor)&oldid=795920148"

value: This website is the English-language edition of the free online encyclopedia Wikipedia. It was founded on 15 January 2001 as Wikipedia's first edition and, as of October 2021, has the most articles of any edition, at 6,412,521.


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Words containing bergastingly | Words that contain bergastingly
Words containing bergastingly | Words that contain bergastingly http://www.thefreedictionary.com/words-containing-bergastinglyPrinter Friendly
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Words containing bergastingly
Found 1 words containing bergastingly. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that contain bergastingly. Or use our Unscramble word solver to find your best possible play! Related: Words that end in bergastingly
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