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The effects of Bruton tyrosine kinase inhibition on chemotaxis and superoxide generation in human neutrophils. - PubMed - NCBI
AbstractFormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListApplySend to:Choose DestinationFileClipboardCollectionsE-mailOrderMy BibliographyCitation managerFormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVCreate File1 selected item: 24771458FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataE-mailSubjectAdditional textE-mailDidn't get the message? Find out why...Add to ClipboardAdd to CollectionsOrder articlesAdd to My BibliographyGenerate a file for use with external citation management software.Create File
See comment in PubMed Commons belowJ Clin Immunol. 2014 Jul;34(5):555-60. doi: 10.1007/s10875-014-0046-z. Epub 2014 Apr 26.The effects of Bruton tyrosine kinase inhibition on chemotaxis and superoxide generation in human neutrophils.Broides A1, Hadad N, Levy J, Levy R.Author information1Pediatric Immunology Clinic, Soroka University Medical Center, POB 151, Beer-Sheva, Israel, 84101, broides@bgu.ac.il.AbstractPURPOSE: The role of the Bruton tyrosine kinase (Btk) protein in neutrophil function has been evaluated using neutrophils from healthy volunteers after incubation with a Btk inhibitor, leflunomide metabolite analog (LFM-A13), suggesting an important role for Btk in neutrophil function. We sought to determine the role of Btk protein on neutrophil superoxide generation and chemotaxis stimulated by N-formyl-methionine-leucine-phenylalanine (fMLP).METHODS: Chemotaxis was assayed on agarose gel and superoxide generation by cytochrome C reduction. The affects of LFM-A13 on chemotaxis and superoxide generation in unstimulated and fMLP stimulated neutrophils were studied in Btk deficient neutrophils from XLA patients compared with matched controls analyzed simultaneously.RESULTS: Chemotaxis and stimulated superoxide production were similar in the normal and Btk deficient neutrophils and were similarly inhibited by LFM-A13. In one patient, LFMA13 had no effect on superoxide generation in Btk deficient neutrophils up to a concentration of 25 microM, while inhibited superoxide production by control neutrophils.CONCLUSIONS: Our results suggest that Btk does not have a specific role in neutrophil fMLP-stimulated superoxide generation and chemotaxis since these activities were similarly inhibited by LFM-A13 in Btk deficient and normal neutrophils. The lack of superoxide generation following Btk inhibition by LFM-A13 in Btk deficient neutrophils from one patient may suggest some heterogeneity in the role of Btk in fMLP induced neutrophil superoxide generation.PMID: 24771458 [PubMed - indexed for MEDLINE] SharePublication Types, MeSH Terms, Substances, Supplementary ConceptsPublication TypesResearch Support, Non-U.S. Gov'tMeSH TermsAdolescentAgammaglobulinemia/enzymology*Agammaglobulinemia/geneticsAgammaglobulinemia/pathologyAmides/pharmacology*Case-Control StudiesChemotactic Factors/pharmacologyChemotaxis, Leukocyte/drug effectsChildChild, PreschoolGene ExpressionGenetic Diseases, X-Linked/enzymology*Genetic Diseases, X-Linked/geneticsGenetic Diseases, X-Linked/pathologyHumansInfantMaleN-Formylmethionine Leucyl-Phenylalanine/pharmacologyNeutrophils/drug effects*Neutrophils/enzymologyNeutrophils/pathologyNitriles/pharmacology*Primary Cell CultureProtein Kinase Inhibitors/pharmacology*Protein-Tyrosine Kinases/antagonists & inhibitors*Protein-Tyrosine Kinases/geneticsProtein-Tyrosine Kinases/metabolismSuperoxides/metabolism*Young AdultSubstancesAmidesChemotactic FactorsLFM A13NitrilesProtein Kinase InhibitorsSuperoxidesN-Formylmethionine Leucyl-PhenylalanineAgammaglobulinaemia tyrosine kinaseProtein-Tyrosine KinasesSupplementary ConceptsBruton type agammaglobulinemiaLinkOut - more resourcesFull Text SourcesSpringerPubMed Commons home

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Beautiful chandelier! It looks amazing with our decor. It was a little time consuming to put together but not difficult. We got an electrician to install it while he was there installing new electrical outlets. It did not take him very long. It is the perfect addition to the space. Looks very trendy with the rest of out boho decor. I am very very happy with the purchase. I would buy again in a heart beat.
This light fixture will look beautiful in our new home. The finish is a matte black that will go nicely with the rustic look we are trying to capture. The assembly is very tedious as there are several pieces to assemble to the main body of the light. A great buy for the price.
We just bought a house and the old chandelier had to go!!! This chandelier was a little bigger than I was expecting but I absolutely love it! The installation wasn’t too bad, but it did take about an hour for someone who is relative familiar with electrical stuff.
Victoria S. Aug 23, 2018
Beautiful chandelier. It was the perfect size for my dining room. Husband said there were many parts and assembly was time consuming. My father and husband put it together in 3 hours. I love the look and how it came out!
Leo Anthony O. Jul 12, 2018
The chandelier is beautiful. It goes with my farmhouse look. It was the perfect size and color for my dining room. It took me about an hour to put together. My husband hung the chandelier without any problems. The chandelier came with shades, but I prefer the chandelier without them. This chandelier gives off a lot of light. This is the second chandelier I have purchased from Overstock and I will purchase more items from them. Their prices and fast shipments can’t be beat. I highly recommend this chandler. You won’t be disappointed.
Carrie D. Jun 25, 2018
Beautiful chandelier. Clean line, simple and modern. Not too frilly. Easy to install, just as pictured. Quick shipping and all came in tact with all the parts.
amorris0377 Jun 5, 2018
Exactly what I was going for in our dinning room!!! Elegant modern farmhouse
OstkUser856263 Sep 20, 2018
Well made and elegant. We hung without the optional lamp shades and without the additional black half circles between each arm. Simple and chic.
I got this for my bedroom. Looks great! easy assembly. Id recommend buying electrical tape for when the wired need to be connected.
maria l. Sep 13, 2018
We haven’t gotten this installed yet but I put it together and it’s beautiful. Exactly what I wanted.
Teresa S. Sep 11, 2018
Beautiful fixture and a great value! However, assembly was extremely tedious and time consuming. Would have been easier if the hardware came all together in a bag, instead of having to take apart certain pieces then have to put it right back together.
OstkUser2615911 Sep 3, 2018
So happy with this purchase, the chandelier looks great in out dining room. It is the perfect compliment to our space. Great purchase at an even better price.
Had to put this together which really was not the bad. Not sure I care for the shades however I will keep them on when we move in and then make a decision.
chris g. Sep 1, 2018
looks good in the space- had to buy a new chain because the one included was too short for the wiring (which was indicated in the description)
Chelsea W. Aug 31, 2018
This chandelier had to be put together, but my husband had it done in no time (he is good at this kind of thing). All the parts were there and we are very happy with it! 4 stars was due to a nut in the center that was silver-we had to paint black.
Ann H. Aug 30, 2018
This was a great price but ended up being too small for the room. The room was huge and it looked a little spindly once we hung it.

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The Saga of Tanya the Evil, Vol. 2 (manga) by Carlo Zen, Paperback | Barnes & Noble® B&N Top 100 NY Times Bestsellers
by Carlo Zen, Chika Tojo (Artist)Carlo Zen
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Saga of Tanya the Evil (manga) Series , #2
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Kaho isn't a thing. You can't treat girls like objects.Although high schooler Kaho and fifth grader Kanade have started dating, Kaho is constantly at the mercy of Kanade's childish whims. And when a mysterious hottie with a Kansai accentwhom Kanade ...
In the mystic realm of Gensokyo, library worker Kosuzuna awakens to her ability to read ...
While Alice and Karen have quickly gotten used to life in Japan thanks to the help of their friends, plenty of new experiences still await themtheir first school festival, summer vacation, an unforgettable Japanese-style(?) Christmas party, and more! The girls ...

value: This website is an American bookseller. It is a Fortune 1000 company and the bookseller with the largest number of retail outlets in the United States.


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Healing Through the Chakras (Audiobook) by Cyndi Dale | Audible.com
This instructional drops off abruptly as a previous reviewer also stated.
There is no conclusion to the material whatsoever and the listener is left feeling like they have missed several chapters.
Just as the material is getting into some depth it ends.
Not sure if there was more to the original audio that we are missing???
Was Healing Through the Chakras worth the listening time?
The material is interesting but there wasn't enough of it and I don't think that was the lesson in it's entirety, If that was the entire lesson it was poorly done.
This information is contained in Cyndi’s other book ADVANCED CHAKRA HEALING. I recommend buying ADVANCED CHAKRA HEALING instead.
Interesting, informative, healing.
Always love whatever Cyndi Dale has to offer! She has that rare gift of explaining complex ideas and concepts as to be easily understood .

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Russia expels more British diplomats over spy poisoning row | UK news | The Guardian
Moscow orders diplomatic staff to be reduced to same level as Russian missions in Britain
Fri 30 Mar 2018 11.51 EDT Last modified on Fri 24 Aug 2018 07.20 EDT
The British embassy in Moscow. Britain has been given 30 days to cut its diplomatic staff there. Photograph: Tass/Barcroft Images
Russia has announced a further round of expulsions of British diplomats, escalating the fallout over the poisoning of Sergei Skripal and his daughter.
Britain has pointed the finger firmly at the Kremlin for the Salisbury attack and expelled 23 Russian diplomats, a move swiftly followed in kind by Russia, which also closed down the British Council, the cultural arm of the British government.
The Russians have now ordered Britain to reduce its diplomatic staff in Russia to the same level as Russian diplomatic missions in the UK. It comes after irritation in Moscow that Britain has persuaded so many other countries to expel Russians.
Russian officials have been taken aback by the level of coordination in the expulsions, and the number of countries willing to go along with Britain. The US expelled 60 Russian diplomats and Ukraine 13, while many other countries expelled smaller numbers.
In total, more than 150 Russian diplomats, many of whom are believed to be intelligence operatives working under diplomatic cover, have been expelled from two dozen countries.
On Thursday, Russia made symmetrical responses to all the countries that expelled its diplomats, and now Britain has been given 30 days to reduce the number of stationed in Russia.
Russia’s foreign ministry summoned the British ambassador, Laurie Bristow, on Friday morning in light of the “provocative and unsubstantiated actions by Britain, which instigated the expulsion of Russian diplomats from various nations for no reason”.
“It’s regrettable but in light of Russia’s previous behaviour, we anticipated a response,” said a spokesperson for the UK Foreign Office (FCO). “However, this doesn’t change the facts of the matter. The attempted assassination of two people on British soil, for which there is no alternative conclusion other than that the Russian state was culpable.”
It was not immediately clear how many people work at Russia’s UK missions and therefore how many British diplomats in Russia will need to be shed.
The Russian embassy in London said via a Twitter direct message that “the British side is aware of the figures in question” but declined to give a number, while a spokesperson for the embassy in Moscow said it was too early to say, and that the FCO did not give figures for employees at its missions due to security reasons.
Russia has vehemently denied being behind the attack on Skripal, who was sent to Britain during a 2010 spy swap. Scientists have determined the Skripals were poisoned using novichok, a nerve agent produced in the Soviet Union.
The preferred narrative in Russia is that Britain orchestrated the attack as a “false flag” operation to cast blame on Russia. Andrei Bezrukov, formerly a deep cover Russian spy in the US, said on state television this week that the poisoning was a diversionary tactic organised by the Tory government to save Theresa May.
The foreign ministry spokeswoman, Maria Zakharova, has suggested the same, posting on Facebook a clip from the 1980s comedy Yes Prime Minister, in which the characters consider expelling Russian diplomats to distract attention from a scandal at home.
Zakharova has said the response to the Salisbury incident has been “a huge manipulation of public opinion with the participation of the British authorities”, while Russian officials have accused the UK of hiding evidence.
On Thursday, reports emerged that Yulia Skripal, 33, is conscious and talking, having apparently made a surprising recovery from what was considered a grave condition. Her father’s condition is described as critical but stable.
Investigators continue a massive operation to determine how the poisoning took place, with the latest reports suggesting the poison was most likely placed on the front door handle at Skripal’s house.

value: This website is a British news and media website owned by the Guardian Media Group. It contains nearly all of the content of the newspapers The Guardian and The Observer, as well as a substantial body of web-only work produced by its own staff, including a rolling news service.


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3 bedroom detached bungalow for sale in Knowle Road, Fairlight, East Sussex, TN35
www.rightmove.co.uk/property/57072625
Knowle Road, Fairlight, East Sussex
PCM Estate Agents are delighted to offer for sale an opportunity to secure this well proportioned three bedroom detached bungalow situated in the highly sought after village of Fairlight within reach of Hastings Country Park and access to roads leading to the nearby town of Hastings with its comprehensive range of shopping, sporting, recreational facilities and mainline railway station. The property enjoys spacious accommodation including a 26ft lounge/diner plus three bedrooms with a bathroom and wc and separate wc. Benefits of this bungalow include gas central heating, double glazing, off road parking for multiple vehicles plus garage and gardens to the front and rear. Early viewing is considered essential for those seeking a village home. Call now on 01424 839111 to book your immediate appointment to avoid disappointment.
Part glazed front door with coloured glass feature to:
Entrance Vestibule - Enclosed, part glazed double doors opening to:
Entrance Hall - Radiator, trap hatch to loft space, airing cupboard with hot water cylinder.
Kitchen - 9'9 x 8'9 (2.97m x 2.67m) - Double glazed window to side aspect, part tiled walls, stainless steel inset 1 1/2 bowl sink, range of base units comprising cupboards and drawers set beneath working surfaces, matching wall units over, integrated cooker hood, gas point, glass display unit, plumbing for washing machine, plumbing for dishwasher, open end shelf, double glazed door opening to rear garden.
Lounge/Diner - 26'3 max narrowing to 14'10 x 12'6 max (8.00m max - L Shaped Room. Double glazed windows to rear aspect, two radiators, wall light point, feature brick fireplace extending to side displays with fitted gas fire and brick hearth, double glazed sliding patio doors opening to rear garden.
Bedroom One - 14'1 max x 11'7 max (4.29m max x 3.53m max) - Double glazed bay window to front aspect with fitted window seat with cupboards beneath, further double glazed window to side aspect, range of fitted wardrobes with sliding doors and cupboards over, radiator.
Bedroom Two - 11'7 x 9'5 (3.53m x 2.87m) - Double glazed window to side aspect, radiator.
Bedroom Three - 9'11 x 7'7 (3.02m x 2.31m) - Double glazed window to front aspect, radiator.
Bathroom - Double glazed windows to side aspect, part tiled walls, panel corner bath, pedestal wash hand basin, low level wc, tiled shower cubicle, radiator.
Separate Wc - Low level wc, wash hand basin with tiled splashback, tiled floor.
Garage - Up and over door, lights, power point, wall mounted gas boiler, personal door to rear.
Rear Garden - Patio with steps up to further paved area with flowerbeds and shrubs and leading to gardens laid to lawn with further flowerbeds, trees and shrubs, sheds, exterior light with rear access gate leading to Knowle Woods, side access and outside tap.
To view this media, please visit the on-line version of this page at www.rightmove.co.uk/property-for-sale/property-57072625.html
Disclaimer - Property reference 26648467. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by PCM Estate Agents, Hastings. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.
26 Jun 2015 49 Knowle Road, TN35 £285,000
11 Apr 2014 44 Knowle Road, TN35 £215,000

value: This website is a UK-based company that runs rightmove.co.uk, the UK's largest online real estate portal and property website. It is listed on the London Stock Exchange and is a constituent of the FTSE 100 Index.


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Vegan Vibes Slogan Tote Market Bag for Life Screen Printed | Etsy
Thanks for checking out this item! Please check out my other listings for:

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Shop Vienna Jewelry Gold Plated Classical Wedding Ring with a Modern Twist - Free Shipping On Orders Over $45 - Overstock.com - 11574830
ITEM# 18516316
ITEM#: 18516316


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Argos - A Social CRM Case Study | Testify Digital | Twitter | Social Media
Uploaded by Testify Digital - Social CRM Agency
A topline look at Argos' social CRM activity with a specific look at a pricing error that spread fast on social media and caused a backlash for the retailer.
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How to engage in Social mobile!
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Argos A Topline Social CRM Audit
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Argos Social Media Monitoring
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Argos Social Media Mentions
A search for social media mentions of Argos over 2 weeks 13/1/12 26/1/12
20,496 total mentions
Twitter Forums Facebook Blogs Comments Videos News 13260 3901 1204 1105 492 191 186
85% of all mentions of Argos are on Twitter Twitter & Forums account for 84% of all mentions
Argos Monitoring Twitter for opportunities
Argos monitor Twitter for more than just their brand terms They monitor for general mentions of products in their sale, then reach out and engage with a Twitter user if they show purchase intent They could also be following users they have identified as influencers and are monitoring for opportunities to inform of their offers. Argos have a wide range of products and as such there are thousands of opportunities to engage
@ArgosHelpers Response rate
Tweets sent to @ArgosHelpers Tweets sent from @ArgosHelpers
@ArgosHelpers is the customer service Twitter account for Argos The trend lines show @ArgosHelpers response rate to @messages over time and show a very responsive account Instances where the messages to ArgosHelpers exceed that of the responses are the result of retweets of an original message to @Argoshelpers
Argos Facebook Customer Service
Argos receive a lot of customer queries and complaints on their Facebook wall. Customers are generally responded to quickly and Argos does a good job of resolving issues in a professional, sympathetic and efficient manner They dont delete posts and as such there is quite a lot of negative comments, however Argos are able to keep their replies constructive and welljudged.
Argos Pricing Error
On Saturday 21/1/12 Argos incorrectly displayed the price of a Nokia Lumia handset at almost its price for several hours
The error was picked up on by @HotDealsUK and other popular Twitter accounts and rapidly spread through Twitter
News of the toogood-to-be-true deal spread fast, and led to social media mentions of Argos being over three times higher than on an average day
3,172 mentions
When directly asked about the deal, @ArgosHelpers tweeted that having looked into it, it appeared to be correct. There was a clear breakdown in communication between Argos different online departments
After several hours Argos noticed and fixed the error, but didnt acknowledge or apologise for it on their Facebook or Twitter pages other than in @message responses to users
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9_PVC-U Butterfly Valve S4 With Pneumatic Actuator | Valve | Actuator
Uploaded by Joyce Sampoerna
Butterfly valve S4 PVC-U with pneumatic actuator
Code 48 Technical data
d DN G C D J K L h Z PN Actuator A B H I Actuator A B H I
mm mm Inch mm mm mm mm mm mm mm bar mm mm mm mm mm mm mm mm
90 110 80 100 3“ 4“ 133,0 155,0 74,5 91,5 152,5-160,0 180,0-190,5 19,0 19,0 226,0 256,0 105,0 120,0 49,0 56,0 10,0 10,0 UT-20 DA UT-25 DA 72,5 72,5 177,0 239,0 441,5 471,5 143,0 143,0 UT-35 SR 72,5 72,5 246,0 246,0 494,5 524,5 196,0 196,0
140 160 225 125 150 200 5“ 6“ 8“ 190,0 216,0 274,0 116,5 134,0 200,5 210,0-216,0 240,0 295,0-298,0 22,0 22,02 22,0 291,0 319,0 391,0 130,0 150,0 180,0 64,0 70,0 71,0 10,0 6,0 6,0 UT-30 DA UT-35 DA 72,5 72,5 72,5 230,0 246,0 246,0 525,5 587,5 659,5 162,0 196,0 196,0 UT-45-SR UT-50-SR 72,5 72,5 140 351,0 351,0 361,0 571,5 599,5 711,5 208,0 208,0 248,0
This print has the purpose of providing information but does not express any guarantees. This program is constantly expanding and therefore the herein shown models are in accordance with state of printing. Subjects to technical modification!
PRAHER – QUALITY – SERVICE – INNOVATION
©Praher Kunststofftechnik GmbH, DB/EV/E/04/06/033/A
Pneumatic actuator Coupling Screw Shim Console Toothed locked washer Nut Butterfly valve Toothed locked washer Screw
General: - Sealing material: EPDM, FPM - Body material: PVC-U – PP - Dimensions: DN80/d90 – 3“ DN200/d225 – 8“ Operating pressure: DN80/d90 - DN125/d140: 10 bar DN150/d160 - DN200/d225: 6bar Connections: Flange DIN,ASTM,ASA:DN80-DN200 Flange JIS: DN80-DN150 Description actuator: piston actuation with 2 opposed pistons, power transmission with tooth rack, seal elastic Material actuator: - Body: aluminium anodised - End caps: aluminium epoxy powder coated - Screws and nuts: stainless steel Ambient temperature: -20°C - +80°C Control fluid: filtered air according to PNEUROP/ISO Class 4 Mounting: in every possible direction Control function/ control pressure: - DA: double acting / max. 10 bar - SR: spring return / max. 8 bar Rotation angle: 90°, adjustment in both directions –10° to +10° Installation: - actuator – valve: ISO 5211 - actuator – solenoid valve: NAMUR (VDI/VDE3845) - actuator – limit switch box: NAMUR (VDI/VDE3845) Applications: - limit switch box - 3/2 and 5/2 solenoid valves
Enclosure IP65 .Cover: Polycarbonate clear .20 UT45 SR 1.Srews and spring: stainless steel Voltage: 24V DC (3W) 230 V AC (5VA) ©Praher Kunststofftechnik GmbH.Solenoid valve Namur with combiened 5/2 and 3/2 ways funktion + standard coil .5 A (24V DC) 3/2 FUNKTION 5/2 FUNKTION General Features .Cable gland M20*1.Seals: EPDM Voltage: 1-250 V Current: 16 A (250V AC) 2.85 UT50 SR 2.Piston: Aluminium . 0.10 UT30 DA 1. DB/EV/E/04/06/033/A PRAHER – QUALITY – SERVICE – INNOVATION Page 2/2 . Lt.Easy change over from 5/2.71 1. 1.45 AIR CONSUMPTION (FULL CYCLE) SR SPRING RETURN Actuator UT35 SR N. Lt.Seals: NBR .Body: Polycarbonate black .Mounting bracket + screws: stainless steel .Butterfly valve PVC-U with pneumatic actuator Code 48 FLOW-PRESSURELOSS Technical data PRESSURE-TEMPERATURE-DIAGRAM AIR CONSUMPTION (FULL CYCLE) DA DOUBLE ACTING Actuator UT20 DA UT25 DA N.90 LIMIT SWITCH BOX SOLENOID VALVE NAMUR General Feature .Limit switch box with 2 mechanical switches Croucet .40 UT35 DA 2.5 Material .to 3/2-ways operation by innovative sealing-plate to be turn around .Body: Aluminium.Manual override as standard Material . anodised .
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This charming memoir by Bella Chagall recalls her childhood in Vitebsk, the Russian-Jewish market town ...
This charming memoir by Bella Chagall recalls her childhood in Vitebsk, the Russian-Jewish market town where she and her husband, Marc Chagall, grew up. Her warm reminiscences of Jewish family life in pre-Revolutionary Russia are illustrated with thirty-six pen-and-ink drawings ...


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120pcs Dupont Wire Jumper Cable Male to Male + Male to Female + Female to Female | eBay
h-quality_electronic (75230 )
Details about 120pcs Dupont Wire Jumper Cable Male to Male + Male to Female + Female to Female
142039893835
Last updated on 14 Sep, 2019 08:14:35 AEST View all revisions

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