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My only wish is that the on-site restaurant would... - Review of Island House Hotel Orange Beach - a DoubleTree by Hilton - TripAdvisor
“Breakfast - best kept secret in Orange beach”
“Peggy was the lady that booked our room for us...”
“We love the pool, private beach chairs and the...”
“The breakfast buffet at the restaurant was great...”
“And yes, the busy café was quieter than our room”
“We stayed in a condo in Orange Beach the 2nd week...”
“Each room has a balcony with a beach view the...”
“We enjoyed the beach and the pool each day”
“We love the beaches of Orange Beach and the...”
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“Big rooms, comfortable beds And right on the beach”
My only wish is that the on-site restaurant would... - Review of Island House Hotel Orange Beach - a DoubleTree by Hilton
Ranked #5 of 19 Hotels in Orange Beach
The Island House is a great hotel for the price. Located directly on the beach, it has the lowest price of any surrounding hotels. All of the rooms have an ocean view. We stayed on an upper view and had a beautiful unobstructed view. The rooms are clean and tastefully decorated. The bed could have been a bit more comfortable, but I have slept on much worse. The hotel employees are very friendly and very helpful. I would happily stay here again. My only wish is that the on-site restaurant would stay open longer. It closes at 4pm and it would be very nice if it was open for dinner.
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All reviews rooms face the penthouse private balconies mini fridge shrimp basket great view nice pool breakfast buffet ocean view coffee maker gulf of mexico flora bama off season beach josh condo umbrellas
406 - 412 of 577 reviews
genecrunk
Nice, but has some flaws....
The Island House. Where do I begin? The Island House is a nice hotel. There's nothing wrong with it. It's on the beach, which is nice, but a lot of rooms have their views blocked by palm trees. I stayed on the second floor, causing this to happen to me. The Island House has a pool, which is nice, but they have a weird rope thing blocking the middle. I don't understand this. The beach is nice. They have chairs available for 25 dollars a day, which have umbrellas. I liked this. The elevators need to be a little faster, but they work fine. The front desk was nice and helpful, checkin was fast, and the porter helped us with our luggage and didn't expect a tip, though I have him one. I do think it would be nice for both the guests and the management if the hotel room doors had key cards instead of actual keys. If someone lost their key, it would cost management or the guest anything to replace the key except a few cents for the card. The vending machines are nice, though the ice makers were broken. There aren't refrigerators or microwaves in the room, which was a downside. They have a restraunt, but its overpriced. I liked the Island House, but its nothing special.
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SWMommy
Second stay this year
We love this hotel. My husband and I stayed in February and I'm currently here with our son and my parents. The staff are super nice. Rooms are clean with great views and comfortable beds. Beautiful beach to look at on your own private balcony.
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Just went for the 2nd time...July 25-29 and we love it here. I love the fact that all rooms are gulf front. Ice machine worked well and we were always able to fill our large ice chest at any time of day. front desk staff is excellent and polite. I had asked for a high floor before we got there, i like to dolphin watch in the early mornings...got the 9th floor, amazing view. Lobby is always neat and clean with plenty of seating and books/puzzles for you to read or kids to do. Pool area was always clean and was quiet..never heard much noise, especially at night. We went to the beach every day and it was never crowded in the area right behind the hotel. Rooms are always neat, clean and tidy...bed was a little uncomfortable in our particular room, but we made it. Plenty of pillows if you like lots of pillows to prop on. Tv was nice, love the 2 sinks...while hubby was steaming up the bathroom with his shower, i was at the other sink getting ready. Never ran out of hot water, plenty of towels etc....love the room safe and love the fact that you get a real key for your door. We just returned from Vegas in March and we had the card...took us up to 60 tries to get that door open...even after reporting it to the front desk and they said maintenance came and fixed it. We will be coming back here for all of our stays, LOVE IT! Thanks for another great stay Island House!
Room Tip: Ask for a high floor if you like the water view from above
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simschapel
My family of four will definitely stay here again. It was clean and the staff was very nice & helpful. We talked to some other people who were staying there and they all liked it. Even though it rained almost the whole weekend, we still had a fun and relaxing weekend.
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We went down on Friday 7/26 and left this morning. This was a weekend fun getaway for two couples who needed a break at the beach with lots of good laughs and good times. We stayed in a standard room and actually shared a room just to save money. I was kinda worried about that but the room was soooo nice, clean, and spacious. Since we stayed at the beach or was out for lunch or supper, we really didn't need a room with all the bells and whistles. However if we had to to have stayed in the room due to the weather or whatever, it would have been fine. The staff was very friendly and helpful too. The rooms had great bedding, cold AC, good coffee maker and coffee. No mini fridge but we had three coolers so I think we did just fine. There is a safe in the room which was nice to have. The man who helped us to the room with our belongings was soo nice and didnt wxpect a tip or fee like some reviews have said. He was very helpful and it was much appreciated since we had alot of stuff. Bless him! there is also two sinks in the bathroom area which was real handy. The beach was so nice and the pool area was clean. We actually didn't use the pool but I checked it out and it was clean and good condition. The pool has i think has a 3ft kiddie pool and then the large pool. No hot tub though but we didnt mind since we were so sleepy after sun and eating dinner. Our plan was to relax on the beach and that's what we did. :) there is a Shrimp Basket across the street and another shrimp place that steams fresh for you there. And a donut place too. Also, to rent the lounge chairs at the beach it is $25.00 a day or $5.00 an hour. And well worth it too! Loved the place and highly recommend.
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Great views of the Gulf
Great views of the Gulf. The beach is the highlight here. Great white sand and plenty of beach here. There is a park to one side, so you are not squeezes in by other properties. The hotel staff was very friendly and helpful. The hotel does show a little wear and tear, but still very nice. Plenty of large stores close by for your needs and plenty of small ones too. Deep sea fishing place right across the street. Donuts and seafood also across the street. Restaurant in hotel is very reasonable and the food that I had was good. It is only open for breakfast and lunch. Breakfast buffet was only $8.95. We will be back soon!
Room Tip: All rooms have a gulf front view and you get a bay view from all hallways. Upper floors give better...
Ask LPAMIKE about Island House Hotel Orange Beach - a DoubleTree by Hilton
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#11 of 19 in Orange Beach
#5 On the Beach Hotel in Orange Beach
Price Range: $104 - $326 (Based on Average Rates for a Standard Room)
TripAdvisor is proud to partner with Booking.com, Expedia, Hilton Hotels Direct, Hotels.com, Travelocity, Orbitz and Cancelon so you can book your Island House Hotel Orange Beach - a DoubleTree by Hilton reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


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BrowseInterestsBiography & MemoirBusiness & LeadershipFiction & LiteraturePolitics & EconomyHealth & WellnessSociety & CultureHappiness & Self-HelpMystery, Thriller & CrimeHistoryYoung AdultBrowse byBooksAudiobooksArticlesSheet MusicBrowse allUploadSign inJoinColombia: An Attractive Destination for Medical Device & Pharmaceutical ResearchAbout Us
Interventional Concepts, Inc. is a full service Contract Research Organization (CRO) focused on the medical device and biopharmaceutical industry. We help you reach your clinical development and research goals by partnering you with our centers of excellence in Colombia, South America. Our services include:
o o o o o o o o o o o FIM studies. Medical device feasibility trials. Phase I – IV clinical trials. Trial design and protocol submission for regulatory approval. Subject stratification for enrollment. Site management services. Clinical trial execution. Medical device or component shipping, logistics and importation. Case report form (CRF) and instruction booklet design. Animal Research. Cadaver and animal medical device training.
Interventional Concepts, Inc. was founded in 2010 by Pedro Martinez-Clark, M.D., an interventional cardiologist trained at Harvard University’s Beth Israel Deaconess Medical Center. Dr. Martinez-Clark was part of the International Medicine Institute where he acquired extensive experience in international clinical trials and program development. He currently serves as Chief Medical Officer for Interventional Concepts, Inc.
Cardiology Oncology Diabetics Endocrinology Infectology Vaccination Chronic obstructive pulmonary disease • Pneumology • Rheumatology • • • • • • • • • • • • • • • • Internal medicine Hematology Ophthalmology Gynecology Pediatrics Psychiatry Dermatology Nephrology Gastroenterology
• “I can only say good things about our experience in Colombia” –Dr. John B. Simpson. CEO, Avinger, Inc. • “A rediscovered country” –The Financial Times
• Colombia has 42% of the best hospitals in Latin
America – América Economía magazine. • Health System ranks 1st in Latin America –World Health
• • • • • • • • • • • Colombian medicine is well known in the world as a pioneer and leader in health services. Colombia receives about 600 annual clinical trials. More than 20 years of clinical trial industry as a country. Over 115 government-certified research sites. High enrollment rate. Fast and predictable regulatory process (1-3 months). Competitive rates. Highly motivated & bilingual investigators. Great healthcare infrastructure. Fast product importation (Free Trade Agreement with U.S.). EST time zone, located at just a short flight from Miami, FL.
“The country’s $370bn economy is booming, with output growing at 6 per cent a year. A free trade deal has been closed with the US and foreign investment is rolling in, especially into mining and energy.”
“Colombia is emerging as an attractive destination for investors as it works to distance itself from its troubled past.” September 18, 2011
“The nation enjoys economic and political stability, a hardworking and entrepreneurial culture, high levels of productivity and performance in selected sectors and a number of world-class companies.”
Colombia is the Third Largest Contributor to Growth in Latin America.
Although Argentina represents a larger share of Latin America's GDP, its growth was lower than Colombia's
(%) Share of the GDP 2011
Countries' contribution to the growth of the GDP in Latin America 2000 – 2011 (+166%) LATIN AMERICA Variation 166% 2000 - 2011 +376%
BRAZIL MEXICO COLOMBIA VENEZUELA CHILE
94% 23% 12% 12% 8% 8% 6%
+159% +320% +287%
+315% +398%
Source: EIU, 6 February 2012
A Competitive Location with Easy Access to the Americas
Canadá Estados Unidos Caribe Venezuela Ecuador Perú
Flight Time (hours:minutes)
Colombia – New York : 5:35 Colombia – Miami: 3:00 Colombia – Mexico City: 4:45 Colombia – Caracas (Venezuela): 1:20 Brasil Colombia – Lima (Peru): 3:00 Colombia – Sao Pablo (Brasil): 5:45 Colombia – Santiago (Chile): 5:00 Argentina
Colombia – Buenos Aires (Argentina): 6:15
Colombia Safety Progress
Economic Growth vs Security- Colombia
GDP – Growth Rate (%)
GDP- Growth Rate
Source: DANE, Cuentas Nacionales, ANDI “Monthly Industrial Survey”
Bogota, Colombia Security in Perspective
Bogota Miami Washington, DC Detroit New York
Sau Paulo Mexico City
Crime Index Safety Scale
Universal Access to Health Care = High Patient Recruitment Rates
• CBSET – Preclinical contract research
• Accelence – Bordeaux Clinical Research Network.
• Atlantis Global Research Institute.
• • • • • • • • • • • University of Miami DirectFlow Medical Mitralign Roxwood Medical InterValve Avinger Celanova Neuro Tronik Syntheon Medical Accumed Systems Corquest Medical
More From This UserClínica Oftalmológica del Caribe (COFCA) ColombiaShorten trial startup. Lower your costs. Recruit more patients, faster. All in Colombia!Interventional Concepts, Inc.Interventional Concepts 3-Page Foldable BrochureFreedom & Responsibility Culture at Interventional Concepts, Inc. Company Profile Interventional Concepts, Inc.Investigación con dispositivos medicos prototipo en humanos en Colombia_ProexportComo Ganar 50%-140% de Retorno en Menos de 90 Días Invirtiendo en Acciones de la Bolsa PURCHASE ONLYBusiness Plan for an International Medicine DepartmentLa Cebolla de Pandora-Los Beneficios de La Ignorancia...y Los Privilegios Del Conocimiento (Introducción)El enigma del año 20122012 Enigma Flyer2012 Enigma
Interventional Concepts, Inc - CRO Services Presentation by Julio Martinez-Clark116 viewsEmbedDownloadDescriptionInterventional Concepts, Inc., a full-service CRO, helps medical devices manufacturers and biopharma companies conduct their clinical trials in Colombia. With a high enrollment rate, fast and predi...Interventional Concepts, Inc., a full-service CRO, helps medical devices manufacturers and biopharma companies conduct their clinical trials in Colombia. With a high enrollment rate, fast and predictable regulatory environment, competitive rates, highly motivated and bilingual investigators, Colombia is the premier destination for conducting clinical research. Colombia is conveniently located at just a short flight from Miami, FL. Several CROs in Latin America have reported annual growth of about 35% to 50%. It's expected that in the next few years, Latin America will double its current volume of over 4,500 trials. Clinical trials in Colombia have been conducted since the early 80s, today is the 6th Latin-American country in volume of clinical trials and receives about 600 annual trials; almost 10% of all the trials in Latin America. Colombia, with over 115 governement-certified clinical research centers, receives Phase I (medical devices only), Phase II, III, and IV (pharmaceutical and medical device) clinical trials. The following are the therapeutic areas where Colombia excels, in descending order of volume: Diabetics, endocrinology, cardiology, oncology, infectology, vaccination, chronic obstructive pulmonary disease, pneumology, Rheumatology, internal medicine, hematology, ophthalmology, gynecology, and in less proportion, pediatrics, Psychiatry, dermatology, nephrology, and gastroenterology. Interests: Types, PresentationsRead on Scribd mobile: iPhone, iPad and Android.Copyright: Attribution Non-Commercial (BY-NC)Download as PPTX, PDF, TXT or read online from ScribdFlag for inappropriate contentShow moreShow less
RelatedShorten trial startup. Lower your costs. Recruit more patients, faster. All in Colombia!by Julio Martinez-ClarkInterventional Concepts 3-Page Foldable Brochureby Julio Martinez-ClarkClínica Oftalmológica del Caribe (COFCA) Colombiaby Julio Martinez-ClarkFreedom & Responsibility Culture at Interventional Concepts, Inc. by Julio Martinez-ClarkInterventional Concepts, Inc.: clinical research consulting services for biopharma and medical device companies looking to conduct early stage clinical developmentby Julio Martinez-ClarkSustain-T Flyer A5 2014 LA--EUby Luis HernandezMBA IBC Columbia 2015 Handbook[1]by Elmem PopescuColombiaby chrisdaviscngMingas Letter to Obama RE Columbia Feb 2010by Kim HedumECOSISITEMAS (INGLÉS)by David García GAtlantic Republicanism in Nineteenth-Century Colombia_ Spanish Amby Tiaret KimyaHorizons Clinical Research Centerby horizonscrcAssured Labor Colombiaby sii_stafferADC 3 Korektura1.Inddby Erick Rangga JuniorClinical Research in India - Vital or Fatalby sushantmishra85Firmex - Case Study - Excaliard Pharmaceuticalsby FirmexNew Microsoft Word Documentby DrRudra ChakrabortyClinical Researchby Ajay SainiPI Briefing on Clinical Trialsby Political IntelligenceCraby soutikjoyPurcaru Rogozea Plos Oneby r_lilianaSouthern Illinois University School of Medicine Becomes Clinical Site for CEL-SCI’s Global Phase III Immunotherapy Head and Neck Cancer Trialby kindhearteddeal33Untitledby eurolexRegulatory India Synthes Medical Pvt Ltdby Vivek MalhotraUntitledby eurolexUntitledby api-275561671Pharma Plant A Press Briefing July 2011by Andres Rodriguez SeijoPatent Ductus Arteriosus Global Clinical Trialsby Venkat KameshwarSimilar to Interventional Concepts, Inc - CRO Services PresentationShorten trial startup. Lower your costs. Recruit more patients, faster. All in Colombia!Interventional Concepts 3-Page Foldable BrochureClínica Oftalmológica del Caribe (COFCA) ColombiaFreedom & Responsibility Culture at Interventional Concepts, Inc. Interventional Concepts, Inc.Sustain-T Flyer A5 2014 LA--EUMBA IBC Columbia 2015 Handbook[1]ColombiaMingas Letter to Obama RE Columbia Feb 2010ECOSISITEMAS (INGLÉS)Atlantic Republicanism in Nineteenth-Century Colombia_ Spanish AmHorizons Clinical Research CenterAssured Labor ColombiaADC 3 Korektura1.InddClinical Research in India - Vital or FatalFirmex - Case Study - Excaliard PharmaceuticalsNew Microsoft Word DocumentClinical ResearchPI Briefing on Clinical TrialsCraPurcaru Rogozea Plos OneSouthern Illinois University School of Medicine Becomes Clinical Site for CEL-SCI’s Global Phase III Immunotherapy Head and Neck Cancer TrialUntitledRegulatory India Synthes Medical Pvt LtdUntitledUntitledPharma Plant A Press Briefing July 2011Patent Ductus Arteriosus Global Clinical TrialsINC FactSheet 7-19-11Drug Development Workshop - Brochure Interventional Concepts, Inc - CRO Services Presentation

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MAP kinase phosphatases. - PubMed - NCBI
Format: AbstractFormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListApplySend toChoose DestinationFileClipboardCollectionsE-mailOrderMy BibliographyCitation managerFormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVCreate File1 selected item: 12184814FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataE-mailSubjectAdditional textE-mailDidn't get the message? Find out why...Add to ClipboardAdd to CollectionsOrder articlesAdd to My BibliographyGenerate a file for use with external citation management software.Create File
See comment in PubMed Commons belowGenome Biol. 2002 Jun 26;3(7):REVIEWS3009. Epub 2002 Jun 26.MAP kinase phosphatases.Theodosiou A1, Ashworth A.Author information1The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Fulham Road, London SW3 6JB, UK. alana@icr.ac.ukAbstractMitogen-activated protein MAP kinases are key signal-transducing enzymes that are activated by a wide range of extracellular stimuli. They are responsible for the induction of a number of cellular responses, such as changes in gene expression, proliferation, differentiation, cell cycle arrest and apoptosis. Although regulation of MAP kinases by a phosphorylation cascade has long been recognized as significant, their inactivation through the action of specific phosphatases has been less studied. An emerging family of structurally distinct dual-specificity serine, threonine and tyrosine phosphatases that act on MAP kinases consists of ten members in mammals, and members have been found in animals, plants and yeast. Three subgroups have been identified that differ in exon structure, sequence and substrate specificity.PMID: 12184814 PMCID: PMC139386 [PubMed - indexed for MEDLINE] Free PMC ArticleShareImages from this publication.See all images (5)Free textFigure 1Gene structure of the DUSPs. Three distinct gene structures have been described for the DUSPs, allowing their classification into subgroups I, II and III. Structural motifs (CH2 domains, docking domain and catalytic domain) in the encoded proteins are indicated by shaded shapes and exons by boxes and roman numerals. The dashed box in subgroup II is an alternatively spliced exon.MAP kinase phosphatasesGenome Biol. 2002;3(7):reviews3009.1-reviews3009.10.Figure 2Phylogenetic analysis of DUSP sequences. Human DUSP amino-acid sequences were aligned and a phylogenetic tree derived using Clustal W [68] on DNASTAR. The length of the branches is proportional to sequence divergence between proteins. Subgroups I, II, and III are shaded (see text for further details).MAP kinase phosphatasesGenome Biol. 2002;3(7):reviews3009.1-reviews3009.10.Figure 3Three-dimensional structure of DUSP6. (a) The amino-terminal Erk-binding (EB) domain, reproduced with permission from [38]. (b) The catalytic domain, reproduced with permission from [24].MAP kinase phosphatasesGenome Biol. 2002;3(7):reviews3009.1-reviews3009.10.Figure 4Classification of DUSPs on the basis of MAP kinase docking site. The sequence thought to be responsible for MAP kinase interaction in DUSPs is shown, as is substrate preference. This results in a DUSP subclassification similar to that obtained by analysis of gene structure (Figure ) or amino-acid sequence similarity (Figure ). Adapted from [14].MAP kinase phosphatasesGenome Biol. 2002;3(7):reviews3009.1-reviews3009.10.Figure 5Activation of DUSP6 phosphatase by interaction with substrate ERK. This is a simplified schematic representation of ERK binding to DUSP6, resulting in catalytic activation. The carboxy-terminal catalytic domain is represented by a circle and the amino terminus containing the ERK binding (EB) domain by a rectangle. DUSP6 appears to exist in a low-activity state until binding to ERK through the EB domain results in a conformational change, triggering activation of the phosphatase. This results in ERK dephosphorylation and subsequent dissociation of the complex.MAP kinase phosphatasesGenome Biol. 2002;3(7):reviews3009.1-reviews3009.10.Publication Types, MeSH Terms, SubstancesPublication TypesResearch Support, Non-U.S. Gov'tReviewMeSH TermsAmino Acid SequenceAnimalsBinding SitesCatalytic DomainEvolution, MolecularMitogen-Activated Protein Kinases/metabolism*Models, MolecularMolecular Sequence DataPhosphoprotein Phosphatases*/chemistryPhosphoprotein Phosphatases*/classificationPhosphoprotein Phosphatases*/geneticsPhosphoprotein Phosphatases*/physiologyPhylogenyProtein Structure, TertiarySequence AlignmentSubstrate SpecificitySubstancesMitogen-Activated Protein KinasesPhosphoprotein PhosphatasesLinkOut - more resourcesFull Text SourcesEurope PubMed CentralPubMed CentralPubMed Central CanadaMolecular Biology DatabasesKOMP RepositoryMouse Genome Informatics (MGI)PubMed Commons home

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Registered Nurse Jobs, Employment in Sebastian, FL
Registered Nurse jobs in Sebastian, FL
Med Surg RN / Registered Nurse As one of the largest... you deserve. MSN matches Medical Surgical Registered Nurses like you with top healthcare facilities in... Sponsored by Medical Staffing Network - 2 days ago
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thE VAlIdIty of thE lAbour thEory of VAluE for An Introduction to Marxist Economic Theory by Ernest Mandel
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