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Indian Bond Volatility at One-Week High Before RBI Rate Decision - Bloomberg
Bloomberg Anywhere Remote LoginDownload SoftwareService Center MENU Homepage Markets Stocks Currencies Commodities Rates + Bonds Economics Magazine Benchmark Watchlist Economic Calendar Tech U.S. Global Startups Cybersecurity Digital Media Bloomberg Technology TV Hello World Studio 1.0 Pursuits Cars & Bikes Style & Grooming Spend Watches & Gadgets Food & Drinks Travel Real Estate Art & Design Politics Global Risk Briefing How We’ll Know if Trump Is Making America Great Again Tracking Trump’s Web of Conflicts The Inauguration of Donald J. Trump On the March in Trump’s Capital Opinion View Gadfly Businessweek Subscribe Cover Stories Opening Remarks Etc Features 85th Anniversary Issue Behind The Cover More Science + Energy Graphics Game Plan Small Business Personal Finance Inspire GO The David Rubenstein Show Sponsored Content Bloomberg About The Company Sign In Sign In Subscribe Indian Bond Volatility at One-Week High Before RBI Rate Decision
September 28, 2015, 1:58 AM EDT
September 28, 2015, 8:19 AM EDT
Reserve Bank of India will cut benchmark rate Tuesday: Survey
India said to plan 2.49 trillion rupee second-half borrowing
Swings in India’s benchmark bond rose to a one-week high as investors speculate on the outlook for monetary policy before the central bank’s review on Tuesday.The Reserve Bank of India will reduce the repurchase rate to 7 percent from 7.25 percent, according to 42 of 52 economists surveyed by Bloomberg. One sees a cut to 6.75 percent while nine see no change. Governor Raghuram Rajan will then stay put for the next 12 months, a separate survey shows.“All eyes are on the central bank and its commentary about the path for monetary easing ahead,” said Soumyajit Niyogi, an interest-rate strategist at SBI DFHI Ltd. in Mumbai. “Apart from a cut in the repo rate, the bond market is also expecting an increase in foreign investment limits.”
Ten-day historical volatility for notes due May 2025 rose to 2.28 percent on Monday, the highest since Sept. 18. The yield on the debt rose one basis point to 7.73 percent in Mumbai, the highest level since Sept. 16, according to prices from the central bank’s trading system. The rupee rose 0.2 percent to 66.0475 a dollar, prices from local banks compiled by Bloomberg show. Indian markets were shut on Friday for a public holiday.Global funds have almost exhausted their $30 billion limit for investment in local sovereign bonds, data from the National Securities Depository Ltd. show. India is “committed to a steady expansion in the absolute value of foreign institutional investor participation,” Governor Rajan said in July.Consumer-price inflation, the RBI’s benchmark, eased to 3.66 percent in August from a revised 3.69 percent in July. The CPI gauge has stayed below the monetary authority’s target of 6 percent by January for 12 straight months. Rajan will then target 5 percent inflation for January 2017.India plans to borrow 2.49 trillion rupees in the six months starting Oct 1, according to a government official with direct knowledge of the matter. The plan includes raising 150 billion rupees through gold bonds, the official said, asking not to be identified before a public announcement.The government borrowed 3.5 trillion rupees in the April-September period against planned 3.6 trillion rupees. It had budgeted 6 trillion rupees of gross market borrowing in the whole fiscal year.

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text:
Aluminium DJ Record Storage Flight Case-Holds 100 12" Vinyl LP Box-Tough, Strong | eBay
Black Sabbath "Black Sabbath" 1970 Green Warner Bros
£24.579 bids
`LATEEF,YUSEF`-BYRD JAZZ:FIRST FLIGHT AT THE MOTOR C (US IMPORT) VINYL LP NEW
clockworkculture-australia (26591 )
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AU $79.95 (approx. £44.12) International Standard : tracked-no signature (7 to 15 business days) | See details
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type: global

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text: _.zj.prototype.nf=function(){var a=new Mi;this.H=a;var b=_.Nh.Eb();b.lb=!0;this.R();b.Oa=a;_.nfa(b);a.Za=b;b=_.Yg("Im6cmf").Na()+"/jserror";sia(b);b=_.ab(_.Yg("cfb2h").Na());Pi.buildLabel=b;if(yj)for(var b=yj.H,c=0;c<_.xj.length;c++)b.push(_.xj[c]);var b=window,d,c=new rha,e=b||window,f=e.document.documentElement,g=new Fha(f);a:{for(var l=0;lJamu Seri Dewi Malam - Google+Press question mark to see available shortcut keysHomeCollectionsJoin Google+Send FeedbackHelpRegionPrivacy Policy - Terms of Service - Maps Terms©2017 GoogleSearchSign inAboutSearchSign inJamu Seri Dewi MalamAboutJamu Seri's postsLooks like you've reached the endLooks like you've reached the endUnable to load more. RetryWait while more posts are being loaded

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text:
Immune-related gene signatures predict the outcome of neoadjuvant chemotherapy. - PubMed - NCBI
1 selected item: 24790795
Stoll G1, Enot D2, Mlecnik B3, Galon J3, Zitvogel L4, Kroemer G5.
Université Paris Descartes/Paris V, Sorbonne Paris Cité; Paris, France ; Equipe 11 labellisée Ligue Nationale contre le Cancer ; Cordeliers Research Center; INSERM U1138; Paris, France.
Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus; Villejuif, France.
Université Paris Descartes/Paris V, Sorbonne Paris Cité; Paris, France ; Laboratory of Integrative Cancer Immunology; INSERM U1138; Paris, France ; Cordeliers Research Center; Université Pierre et Marie Curie Paris 6; Paris, France.
INSERM U1015; Villejuif, France ; Faculté de Médecine; Université Paris Sud; Le Kremlin Bicêtre, France ; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507; Villejuif, France.
Université Paris Descartes/Paris V, Sorbonne Paris Cité; Paris, France ; Equipe 11 labellisée Ligue Nationale contre le Cancer ; Cordeliers Research Center; INSERM U1138; Paris, France ; Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus; Villejuif, France ; INSERM, U848; Villejuif, France ; Pôle de Biologie; Hôpital Européen Georges Pompidou, AP-HP; Paris, France.
There is ample evidence that neoadjuvant chemotherapy of breast carcinoma is particularly efficient if the tumor presents signs of either a pre-existent or therapy-induced anticancer immune response. Antineoplastic chemotherapies are particularly beneficial if they succeed in inducing immunogenic cell death, hence converting the tumor into its own therapeutic vaccine. Immunogenic cell death is characterized by a pre-mortem stress response including endoplasmic reticulum stress and autophagy. Based on these premises, we attempted to identify metagenes that reflect an intratumoral immune response or local stress responses in the transcriptomes of breast cancer patients. No consistent correlations between immune- and stress-related metagenes could be identified across several cohorts of patients, representing a total of 1045 mammary carcinomas. Moreover, few if any, of the stress-relevant metagenes influenced the probability of pathological complete response to chemotherapy. In contrast, several immune-relevant metagenes had a significant positive impact on response rates. This applies in particular to a CXCL13-centered, highly reproducible metagene signature reflecting the intratumoral presence of interferon-γ-producing T cells.
autophagy; breast cancer; colorectal cancer; endoplasmic stress; immunogenic cell death; tumor-infiltrating lymphocytes
PMC4004621
10.4161/onci.27884
Figure 1.P value of metagene reproducibility. Each of the candidate metagenes per category constructed from The Cancer Genome Atlas (TCGA) cohort (listed in and named according to the highest weighted gene in the signature) was revaluated in other cohorts, as indicated, and P values were determined by bootstrapping. Metagenes are ranked left to right according to their reproducibility. Box plots of the P values are shown for each group of metagenes per category. Plain and dashed yellow lines delimit highly- (P value < 0.05 for all cohorts), median- (P value < 0.05 for all cohorts except 1) and non-reproducible metagenes.
Oncoimmunology. 2014;3:e27884.
Figure 2. Salient features of reproducible metagenes. Listed are the most important genes contributing to metagenes defined as highly or median-reproducible in . The relative weight of the listed individual mRNA species within each metagene is gray-coded and reflect the correlation coefficient (“component” column of metagene-associated genes listed in ). Shown are only those genes whose coefficient is above 0.14. Genes related to the tumor-associated immune microenvironment are highlighted: red = cytokines, blue = natural killer, green = human leukocyte antigen.
Figure 3. Pearson’s correlations between metagenes within each of the 4 functional categories as determined in 4 distinct breast cancer cohorts. A–D. Reproducibility (P value) calculated based on the variance between metagene data sets within the indicated cohort. E–F. Box plots of correlation matrix (E) elements (or r-values) calculated relative to the TCGA cohort and reproducibility P values (F), either for the complete set of metagenes (in white) or focusing on the subset of reproducible metagenes (in yellow) delimited by yellow lines in A–D (as described in legend). Zero (black) indicates that the pair are uncorrelated, a positive value (red) indicating a correlation and a negative value (green) indicating an inverse relationship.
Figure 4. Pearson correlations (or r-values) between immune-relevant and stress response-relevant metagenes. A–C. Reproducibility (P value) was calculated based on the variance between data sets and by comparison with a null hypothesis distribution (2000 events). D–E. Box plots (D) of correlation matrix elements (or r-values) calculated relative to the TCGA cohort and reproducibility P values (E) either for the complete set of metagenes (in white) or focusing on reproducible metagenes (in yellow) delimited by yellow lines in A–C.
Figure 5. Metagenes derived from target genes of stress-responsive transcription factors. A–G. Analysis of metagenes (see ) derived from the downstream targets of ATF4 (A), ATF6 (B), XBP1 (C) and TFEB (D) transcription factors. A–D. Upper panels indicate the P value of metagene reproducibility in 6 distinct cancer cohorts (refer to legend for details). Middle panels display Pearson’s correlations (or r-values) between immune-relevant metagenes and each of the new metagenes within the TCGA cohort. Yellow lines delimit different levels of reproducibility as described in . Lower panels summarize the reproducibility among additional breast cancer cohorts (similar to ). E–G. Box plots of p-value reproducibility (E; derived from the upper panels in A–D), correlation matrix elements (or r-values) calculated relative to the TCGA cohort (F; derived from the middle panels in A–D) and correlation reproducibility (G; derived from the gray-shaded graphs in the lower panels in A–D).
Figure 6.A–H. Heat map of significance of differential metagene expression between chemotherapy responding and non-responding patients. Signed log P values were computed for each immune (A), ER-stress (B), autophagy (C) or lysosomal (D) response-relevant metagenes (yellow lines delimit different levels of reproducibility as determined in Figure 1,or transcription factor-determined (E–H) metagenes by one-tailed, unpaired Student’s t tests to compare the transcript levels in tumors that underwent complete pathological responses (cPR) with those that failed to respond to chemotherapy. This calculation was done for each cohort and treatment option separately. The “combined” rows represent the signed log P value obtained by the aggregation of the individual data set values by means of Fisher’s method. The color scale represents log (base 10) of P values, with a positive or negative sign to indicate over (red) or under (green) expression, respectively, in samples from patients with cPR relative to samples from non-responders.

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text:
The Oakland Athletics had a rough go of it on Sunday against the Baltimore Orioles. Their offense was stagnant and the pitching was even worse. So in the bottom of the eighth inning, the A's tried something new.
Not Jones' best effort, but it's hard to lay off the high cheese from a catcher.
"That was a surprise. He knew that I was just going to come fastball over and over," Phegley said of the strikeout. "I've hit against a position player before and you go up there thinking you're just going to crush it, so I think he kind of just got overaggressive. I had fun with it, and I feel like some guys enjoyed seeing me do that, but at the same time, it was a tough game for us and it's tough to come in and joke around about it after that."
Phegley then got Mark Trumbo out on a popup to short to retire both batters he faced quickly and easily. The Orioles did go on to win 11-3 despite failing to get a hit off of the Athletics' backup catcher.

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text:
Brachial comments on Congratulation to the 2013 NASCAR Sprint Cup Champion Jimmie Johnsonjump to contentmy subredditsannouncementsArtAskRedditaskscienceawwblogbookscreepydataisbeautifulDIYDocumentariesEarthPornexplainlikeimfiveFitnessfoodfunnyFuturologygadgetsgamingGetMotivatedgifshistoryIAmAInternetIsBeautifulJokesLifeProTipslistentothismildlyinterestingmoviesMusicnewsnosleepnottheonionOldSchoolCoolpersonalfinancephilosophyphotoshopbattlespicsscienceShowerthoughtsspacesportstelevisiontifutodayilearnedTwoXChromosomesUpliftingNewsvideosworldnewsWritingPromptsedit subscriptionsfront-all-random | gadgets-sports-gaming-pics-worldnews-videos-AskReddit-aww-Music-funny-news-movies-books-history-food-philosophy-television-Jokes-Art-DIY-space-Documentaries-Fitness-askscience-nottheonion-todayilearned-personalfinance-gifs-listentothis-IAmA-TwoXChromosomes-creepy-nosleep-GetMotivated-WritingPrompts-LifeProTips-EarthPorn-explainlikeimfive-Showerthoughts-Futurology-photoshopbattles-mildlyinteresting-dataisbeautiful-tifu-OldSchoolCool-UpliftingNews-InternetIsBeautiful-sciencemore » NASCARcommentsrelatedwant to join? sign in or create an account in seconds|Englishlimit my search to /r/NASCARuse the following search parameters to narrow your results:subreddit:subredditfind submissions in "subreddit"author:usernamefind submissions by "username"site:example.comfind submissions from "example.com"url:textsearch for "text" in urlselftext:textsearch for "text" in self post contentsself:yes (or self:no)include (or exclude) self postsnsfw:yes (or nsfw:no)include (or exclude) results marked as NSFWe.g. subreddit:aww site:imgur.com dogsee the search faq for details.advanced search: by author, subreddit...this post was submitted on 17 Nov 2013104 points (76% upvoted)shortlink: remember mereset passwordloginSubmit a new linkSubmit a new text postNASCARsubscribeunsubscribe17,312 readers172 users here now
a community for 6 yearsmessage the moderatorsMODERATORSFranks2000inchTVGordonnycsurferGordonstriped_zebraEarnhardt, Jr.xfile345Earnhardt, Jr.ClarksonianPause#ByrnesStrongr_Nascar_PresidentKeselowskijpGrindEdwardsbeezwacksJuniorCR_7ThreadBotNASCARThreadBotabout moderation team »discussions in /r/NASCAR<>X25 points · 5 comments The @roushfenway mentions can be pretty entertaining sometimes...47 points · 43 comments Dover seating capacity reduced to under 100,000, more seats to be removed22 points · 12 comments NASCAR tweeted that qualifying was at 3:45AM accidentally· 9 comments NASCAR on NBC's Spotify Playlist - Yes, Metallica's Fuel is back.20 points · 160 comments [Discussion Thread] Fast Friday! Xfinity, Sprint Cup Practice; Sprint Cup, CWTS Qualifying: Dover· 3 comments Landon welcomes back CRC Brakleen, as well as his son, Beckham Bear Alan Cassill, to continue busy week9 points · 3 comments 12 Questions with Denny Hamlin· 12 comments In it for the long haul: Denny Hamlin hopes to stay with Joe Gibbs Racing10 points · 57 comments TRASH TALK FRIDAY! - May 29, 20157 points · 20 comments Why are Xfinity tickets so tough to get?103104105Congratulation to the 2013 NASCAR Sprint Cup Champion Jimmie JohnsonSpecial Event (self.NASCAR)submitted 1 year ago by Gordonstriped_zebra228 commentssharecancelsorry, this has been archived and can no longer be voted onloading...sorted by: besttopnewhotcontroversialoldrandomq&ayou are viewing a single comment's thread.view the rest of the comments →[–]HamlinBrachial 1 point2 points3 points 1 year ago (1 child)sorry, this has been archived and can no longer be voted onI admit, I danced a little.
permalinkembedsaveparentgive goldaboutblogaboutvaluesteamsource codeadvertisejobshelpsite rulesFAQwikireddiquettetransparencycontact usapps & toolsAlien Blue iOS appreddit AMA appmobile betabuttons<3reddit goldreddit storeredditgiftsreddit.tvradio redditUse of this site constitutes acceptance of our User Agreement and Privacy Policy {Genitive}. © 2015 reddit inc. All rights reserved.REDDIT and the ALIEN Logo are registered trademarks of reddit inc.create a new accountusername:password:verify password:email: (optional)remember meget the best of reddit emailed to you once a week. learn morecreate accountsign inusername:password:remember mereset passwordsign inWe care about your privacy, and we never spam. By creating an account, you agree to reddit's User Agreement and Privacy Policy. We're proud of them, and you should read them.English [en]العربية [ar]Беларуская мова [be]български език [bg]Bosanski [bs]català [ca]česky [cs]dansk [da]Deutsch [de]Ελληνικά [el]English (Australia) [en-au]English (Canadian) [en-ca]English (Great Britain) [en-gb]English [en-us]Esperanto [eo]español [es]español [es-ar]eesti keel [et]Euskara [eu]فارسی [fa]suomi [fi]français [fr]Gàidhlig [gd]עברית [he]मानक हिन्दी [hi]hrvatski [hr]Magyar [hu]Հայերեն լեզու [hy]Bahasa Indonesia [id]íslenska [is]italiano (Italy) [it]日本語 [ja]ಕನ್ನಡ [kn_IN]한국어 [ko]Latin [la]1337 [leet]LOL [lol]lietuvių kalba [lt]latviešu valoda [lv]Nederlands [nl]Nynorsk [nn]Norsk [no]Arrrrrrrr! [pir]polski [pl]português [pt] (*)português [pt-pt]português brasileiro [pt_BR]română [ro]русский [ru]slovenčina [sk]slovenščina [sl]српски језик [sr]Srpski [sr-la]Svenska [sv]தமிழ் [ta]ภาษาไทย [th]Türkçe [tr]українська мова [uk]Tiếng Việt [vi]中文 [zh] (*) incomplete volunteer to translateπ Rendered by PID 20839 on app-229 at 2015-05-29 20:40:16.748121+00:00 running 5f113a5 country code: US.

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Hornby - R604 - Curve 1st Radius 5010963016043 | eBay
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NBA Draft Blog: Jordan Crawford and Solomon Alabi are still raw prospects - ESPN
Alabi among group with much to prove
Updated: December 2, 2009, 3:42 PM ET
Although it's early in the college basketball season, I've gotten out to a couple of the major preseason tournaments. After broadcasting the Puerto Rico Tip-Off last week, I just returned from the Old Spice Classic in Orlando, Fla. Here's my advice to most of those underclassman that I've seen: "Stay in school."
The Old Spice Classic featured a number of intriguing prospects, but no one that would help an NBA team right now. The one player that stood out with obvious NBA potential, 6-foot-9 Chris Singleton of Florida State, is still a ways off from being a finished product. Here is a breakdown of some of the players in the tournament that NBA teams were locking in on last week, three of whom you can catch in action during the Big Ten/ACC Challenge tonight:
To read Fran Fraschilla's take on what Solomon Alabi, Chris Singleton, Manny Harris and Jordan Crawford must do to reach the NBA, you must be an ESPN Insider.

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Translation degree canada english italian Jobs, Employment | Freelancer
Translation degree canada english italian jobs
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Words containing chostemat | Words that contain chostemat
Words containing chostemat | Words that contain chostemat http://www.thefreedictionary.com/words-containing-chostematPrinter Friendly
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Found 1 words containing chostemat. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that contain chostemat. Or use our Unscramble word solver to find your best possible play!
12 letter words containing chostematSee also12 letter words containing chostematarchostemataSee also:Words without vowelsWords with the letter jWords that end in cWords that start with pWords that start with eWords that start with gWords containing chostemaWords containing chostemata

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text:
www.rightmove.co.uk/property/73643777
Clear potential to extend
ENVIABLE CORNER PLOT - CLEAR POTENTIAL TO EXTEND (Subject to PP) within walking distance of Low Ash Primary! Currently providing THREE BEDROOM ''Family Sized'' accommodation. Handy for many amenities in and around Shipley, Wrose and Five Lane Ends. We feel this popular style of property offers new owners an ideal opportunity to make their own mark. A detailed inspection is essential to appreciate this super plot and vast potential. Contact Robert Watts to arrange YOUR viewing today.
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To view this media, please visit the on-line version of this page at www.rightmove.co.uk/property-for-sale/property-73643777.html
Disclaimer - Property reference HIG180234. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by Robert Watts, Five Lane Ends. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.

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text:
Opinion|The Attacks in Paris Reveal the Strategic Limits of ISIS
Mourners gather to lay flowers outside Le Carillon restaurant.CreditCreditTomas Munita for The New York Times

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Yankee Village Motel - Hotels.com - Hotel rooms with reviews. Discounts and Deals on 85,000 hotels worldwide
All hotels in Ascutney, Vermont, United States of America
43.40913,
“This motel was only 15 minutes away from the museum and was inexpensive. It had a bed and…”
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No-frills motel in Ascutney In Ascutney You'll be within 3 miles (5 km) of Mt Ascutney State Park and 6 miles (10 km) of Old Constitution House with a stay here. Arrowhead Recreation Area is within 6 miles (10 km) and Saint-Gaudens National Historic Site is within 9 miles (15 km).
Free breakfast and parking Yankee Village Motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi in public areas, and free parking. A 24-hour front desk is also at your disposal.
Refrigerators Along with refrigerators, the 20 guestrooms offer microwaves and room service. Hair dryers and showers are also available.

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p38 airbag | eBay
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Dual Twin Bellow Air Bags D2500 Dominator Single Port 1/2" VW Airbag System (Fits: [MK II])
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CEdit Enhancement - CodeProject 10,250,210 members (62,479 online) Sign in
CEdit Enhancement By Daniel Zuppinger, 31 Jan 2001
Download demo project - 39.9 Kb (incl. executable and this documentation) Download source - 6.44 Kb Introduction
goodAnonymous6-Jul-05 20:46 BUG:Can't use point as allowed charstarelli3-May-04 14:07 Re: BUG:Can't use point as allowed charsthanhsonkhach1-Jan-07 15:35 BUG:Can't use point as allowed charstarelli3-May-04 14:06 Good control, but slow...mrollin30-Dec-02 13:27 Bug while filtering input ...cr9726-Nov-02 4:11 Re: My Workaround ...cr9726-Nov-02 22:42 Kill Focus ReflectionChristine Hammond27-Aug-02 11:19 Esc/Close bugJohn W Wilkinson5-Aug-02 0:45 BugS. Ganapathi Raman6-Mar-02 3:29 Last Visit: 31-Dec-99 18:00 Last Update: 6-Dec-13 13:52Refresh1234 Next »
Views 194,930

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Ali Nauman Saleemi - Semantic Scholar
Ali Nauman Saleemi
Comparative Investigation of Supersaturation and Automated Direct Nucleation Control of Crystal Size Distributions using ATR-UV/vis Spectroscopy and FBRM
Ali Nauman Saleemi, Chris D. Rielly, Zoltan K. Nagy
The paper presents a thorough evaluation of different control strategies used in cooling crystallization, namely, unseeded linear cooling, seeded linear cooling, supersaturation control, and… (More)
Automated direct nucleation control for in situ dynamic fines removal in batch cooling crystallization
Secondary nucleation (e.g. due to attrition) and accidental seeding (e.g. from crust on the wall of vessels) are undesired events that often take place during industrial crystallization processes.… (More)
Strategic feedback control of pharmaceutical crystallization systems
Strategic Feedback Control of Pharmaceutical Crystallization Systems i Abstract Crystallization is a widely used purification and separation technique in the pharmaceutical industry. More than 90 %… (More)
Application of quantitative Raman spectroscopy for the monitoring of polymorphic transformation in crystallization processes using a good calibration practice procedure
Elena Simone, Ali Nauman Saleemi, Zoltan K. Nagy
Abstract Polymorphism is the property of a substance to have more than one crystalline form. Polymorphic forms of the same chemical compound can have different physical and chemical properties that… (More)
The Impact of Direct Nucleation Control on Crystal Size Distribution in Pharmaceutical Crystallization Processes
Mohd Rushdi Abu Bakar, Zoltan K. Nagy, Ali Nauman Saleemi, Chris D. Rielly
The control of crystal size distribution (CSD) in pharmaceutical crystallization is of primary importance, as downstream processes such as filtration or drying are greatly affected by the properties… (More)
Active Polymorphic Feedback Control of Crystallization Processes Using a Combined Raman and ATR-UV/Vis Spectroscopy Approach
Elena Simone, Ali Nauman Saleemi, N. Tonnon, Zoltan K. Nagy
The nucleation of the metastable form of a substance or of a mixture of more forms is very common in polymorphic crystallization. Additionally, in industry seed may contain a variable amount of… (More)
Enhancing crystalline properties of a cardiovascular active pharmaceutical ingredient using a process analytical technology based crystallization feedback control strategy.
Ali Nauman Saleemi, Geoffrey David Steele, Nicholas Ian Pedge, Vangi S. Ramachandran, Zoltan K. Nagy
Pharmaceutical regulatory bodies require minimal presence of solvent in an active pharmaceutical ingredient (API) after crystallization. From a processing point of view bigger crystals with minimal… (More)
Monitoring of the combined cooling and antisolvent crystallisation of mixtures of aminobenzoic acid isomers using ATR-UV/vis spectroscopy and FBRM
Abstract During the manufacturing of active pharmaceutical ingredients crystalline products in the purest forms are required. Quite often multiple components are present during crystallisation, which… (More)
Raman, UV, NIR, and Mid‐IR Spectroscopy with Focused Beam Reflectance Measurement in Monitoring Polymorphic Transformations
Raman, UV, NIR, and IR spectroscopy are commonly used techniques to monitor solute concentration and solid composition during crystallization processes of polymorphic compounds. Since a comprehensive… (More)
Periodic steady-state flow crystallization of a pharmaceutical drug using MSMPR operation
Keddon A. Powell, Ali Nauman Saleemi, Chris D. Rielly, Zoltan K. Nagy
Abstract In this paper, a novel concept of periodic mixed suspension mixed product removal (PMSMPR) crystallization process is demonstrated. An integrated array of process analytical technologies… (More)

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The Prudential Spirit of Community Awards honors Vienna and Springfield students with $1,000, medallions and trip to nation's capital
Finalists also named in Buckingham, Fairfax, Richmond, McLean and South Riding
RICHMOND, Va., Feb. 5, 2019 /PRNewswire/ -- Justin Hu, 16, of Vienna and Shayla Young, 13, of Springfield today were named Virginia's top two youth volunteers of 2019 by The Prudential Spirit of Community Awards, a nationwide program honoring young people for outstanding acts of volunteerism. As State Honorees, Justin and Shayla each will receive $1,000, an engraved silver medallion and an all-expense-paid trip in early May to Washington, D.C., where they will join the top two honorees from each of the other states and the District of Columbia for four days of national recognition events. During the trip, 10 students will be named America's top youth volunteers of 2019.
These are Virginia's top youth volunteers of 2019:
Justin, a junior at Madison High School, teaches kung fu to children with disabilities and other challenges, and raises money to address medical and health-related needs in Africa and Asia, through "ABLE Kung Fu," the nonprofit organization he founded in 2016. When he was 6 years old, Justin became infatuated with the Chinese martial arts known as kung fu, and over the next 10 years, he won three championship titles. "This sport has tapped into the best in me, engaging my discipline, grit and honor," he said. "I was convinced that the valuable
lessons learned from the sport should not be available to the few, or even only to the physically fit. I understood that kung fu could be a tool for building minds, morale and accessibility."
He began conducting kung fu classes for kids with disabilities at his church, after-school programs, and summer school, and recruiting other kung fu devotees to help him. It wasn't long before children in his classes blossomed with confidence as they mastered new skills. "Watching young people begin to believe they can become champions in their own lives makes my heart sing," said Justin. As the word about his program spread, Justin was invited to teach kung fu to Special Olympics athletes last year. Through his website, he has raised more than $24,000 in donations for his nonprofit, some of which has been used to install an electric water pump at a school in Senegal. Additionally, he has paid for several pediatric surgeries in Taiwan and China, and a group of his volunteers in California carries musical instruments to teach and perform for underserved villages in those countries. Justin estimates that he and his 25 volunteers have had an impact on more than 6,000 children.
Shayla, a seventh-grader at Irving Middle School, conducted a workshop last year to help residents of a veterans retirement home learn how to make better use of their cell phones. Shayla began volunteering at the Armed Forces Retirement Home in Washington, D.C., when she was 6 years old, as her father was preparing to retire from the Army. Last year, she noticed how difficult it was for some of the veterans there to use technology. "I recognized the struggles that residents were having when using their cell phones," Shayla said. "A lot of the residents are in their 90s, with poor vision and poor hearing." Shayla knew she could help, and came up with the idea of bringing some of her tech-savvy peers to the home to teach the seniors the secrets of getting the most out of their cell phones.
After obtaining permission from officials at the retirement home, Shayla recruited a group of student instructors and created a poster to advertise her workshop. On the day of the event, 11 residents showed up to listen to the young people explain various functions of their cell phones, including how to increase font size, adjust volume and brightness, use password protection, save contacts and link their phones to their email accounts. "The residents were very appreciative of us coming out to help them," said Shayla. "Now they are able to use their phones more effectively." She said she is already planning another workshop to educate additional residents, and to show them how to use the alarm function on their cell phone calendars to remind themselves when to take their medications or when they have doctor appointments.
These are Virginia's Distinguished Finalists for 2019:
Trevor Agee, 18, of Buckingham, Va., a senior at Buckingham County High School, is an active volunteer firefighter, contributing hundreds of hours at his community's volunteer-run fire department, responding to emergencies and helping organize chicken barbeque fundraisers. Encouraged by his father, who is also a firefighter, Trevor started his service as the first participant of the department's junior membership program when he was 15.
Noelle Buice, 18, of Fairfax, Va., a senior at Fairfax High School, is the founder of "Cancer Kickin' Critters," a nonprofit made up of more than 100 volunteer knitters and crocheters that has distributed more than 1,000 hand-made stuffed toys and "critter creation kits" to children fighting cancer. Noelle started her project in the seventh grade, when she started knitting toys and hats while traveling to visit her best friend in the hospital where she was being treated for lymphoma.
Kathleen Gruber, 17, of Richmond, Va., a senior at Maggie L. Walker Governor's School, volunteers for an arts program for kids with and without disabilities, helping to teach dance and singing and becoming fluent in American Sign Language so she could translate for deaf students. Kathleen, who has worked with the organization for the past seven years, got involved after her sister, who has Down syndrome, took dance classes through the program.
Sarah Gu, 16, of McLean, Va., a junior at McLean High School, started "THE WINDOW," an organization that has provided English language learning opportunities to 400 students in need from Shexian, China. Sarah regularly visits Shexian, her mother's hometown, to run her program, and started the project after learning that a childhood friend had to drop out of school to work on a family farm.
Jai Kumar, 16, of South Riding, Va., a junior at Freedom High School, is the co-founder of "ForTrinidad," a charity organization that has sent over 1,000 books, school supplies and Christmas gifts to more than 150 children in Trinidad. First inspired to establish the organization after learning about a teacher's experience growing up in Trinidad, Jai also created "Read a Book, Donate a Book," an initiative that encourages local fifth grade students to donate books as part of a reading challenge.
While in Washington, D.C., the 102 State Honorees – one middle level and one high school student from each state and the District of Columbia – will tour the capital's landmarks, meet top youth volunteers from
other parts of the world, attend a gala awards ceremony at the Smithsonian's National Museum of Natural


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Houses For Sale in Darley Dale, Matlock, Derbyshire - Rightmove
Houses For Sale in Darley Dale, Matlock, Derbyshire Sort:
COUNTRY LIVING WITHOUT THE INCONVENIENCE! A rare opportunity to purchase a deceptively spacious historic family home, close to amenities and occupied by the current owners for the last 32 years. Northwood House offers a balanced blend of modern living and sympathetically ret...
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16, Sir Josephs Lane, Darley Dale, Matlock, Derbyshire, DE4 from station
This four bedroomed detached property is beautifully presented and is situated on a quiet cul-de-sac of similar high quality homes. The property has the benefit of easily managed gardens, a good sized attached single garage and off-road parking along with double glazing and gas central heating. C...
15, Nether Way, Darley Dale, Matlock, Derbyshire, DE4 from station
This well maintained four bedroomed detached family home, occupies an enviable position in a quiet cul-de-sac, on the prestigious Henry Boot Development of similar properties in the popular village of Darley Dale, close to local shops and amenities and well regarded schools. Benefitting from a pr...
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Four bedroomed family residence occupying a pleasant popular and highly convenient location. Guest cloakroom. Sitting room. Upvc conservatory. Fitted kitchen. Spacious feature family room with stove. Master bedroom with feature wet room style en-suite. Three further bedrooms. Family bathroom. Dr...
6, The Meadows, Darley Dale Matlock, Derbyshire, DE4 from station
TPS Estates are proud to offer for sale this spacious semi-detached three storey property attractively finished with coursed natural stone frontage and rendered elevations beneath a slated roof. The four bedroomed accommodation is completed to an excellent standard there is the added advantage t...
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Willow Way, Matlock, Derbyshire, DE4
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Derwent View, Darley Dale, MATLOCK, Derbyshire, DE4 2LB
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A three storey, two bedroom terraced property presented to a modern pleasing standard throughout, sitting within low maintenance gardens with the addition of an off-street parking area.


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Opinion | Appalled by Barr’s Intervention in the Roger Stone Case - The New York Times
Opinion|Appalled by Barr’s Intervention in the Roger Stone Case
https://nyti.ms/38qqRNC
Appalled by Barr’s Intervention in the Roger Stone Case
A reader praises the integrity of the prosecutors who resigned in protest. Also: The burden of being poor; mutual fund disclosure.
The Travails of Poverty
Mutual Fund Disclosure Rules
Re “Justice Dept. Acts to Ease Sentence for a Trump Ally” (front page, Feb. 12):
The interference of senior Justice Department officials in the Roger Stone case is a particularly ominous affront to the rule of law. It is but a short step from intervening on behalf of one of the president’s allies to intervening to ensure harsher punishment for his enemies.
If Attorney General William Barr acted to advance the president’s political agenda, he violated his oath of office and should be impeached.
As for the prosecutors who withdrew from the case and the prosecutor who resigned, I commend them for having the integrity to protest the appalling breach of public trust by senior officials. They are heroes, and I fervently hope that they will someday find themselves on the team assigned to prosecute our lawless president and his henchmen.
Re “Risk of Losing Benefits From Everyday Errors” (news article, Jan. 30):
The quiz that appeared online with the article accurately describes the enormous administrative burdens placed on my clients, homeless individuals and families in New York City, in order to establish their eligibility for shelter, food stamps, Medicaid and cash assistance.
Many of my clients have experienced the trauma of domestic violence or have mental health challenges and learning disabilities. It is cruel and inhumane to add the burden of having to navigate complex paperwork and bureaucracies to obtain benefits that provide for basic necessities.
Our government should not be setting up roadblocks to assistance, but rather simplifying processes.
Lisa C. Pearlstein
The writer is project director, Legal Clinic for the Homeless at the City Bar Justice Center.
Re “Mutual Funds Are Still Keeping Secrets” (Op-Ed, Feb. 4):
Arthur Levitt claims that the Investment Company Institute asked the Securities and Exchange Commission to “water down” disclosure requirements.
That’s not true. The institute has worked for years with the S.E.C. to modernize shareholder report delivery to help save shareholders millions of dollars every year. Notice and access achieves this goal and helps improve communication by supplying shareholders with disclosures in a format that is engaging, easy to understand and provides access to more information.
In 2021, funds may notify shareholders of the availability of their semiannual and annual report. The notice must include a direct link to the applicable report and instructions on how a shareholder can receive, free of charge, a paper copy. Funds also deliver yearly a summary prospectus, which includes a link to the full prospectus.
I.C.I. continues to work with the S.E.C. to allow funds to use a summary shareholder report, mirroring the design of the successful summary prospectus.
Mr. Levitt seems to measure disclosures by their number and complexity rather than their usefulness. By contrast, the institute is working with the S.E.C. to help funds provide communications that are effective and user-friendly, and in the form that shareholders prefer.
The writer is president and chief executive of the Investment Company Institute.


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In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. - PubMed - NCBI
Format: AbstractFormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListApplySend toChoose DestinationFileClipboardCollectionsE-mailOrderMy BibliographyCitation managerFormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVCreate File1 selected item: 18054571FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataE-mailSubjectAdditional textE-mailDidn't get the message? Find out why...Add to ClipboardAdd to CollectionsOrder articlesAdd to My BibliographyGenerate a file for use with external citation management software.Create File
See comment in PubMed Commons belowGastroenterology. 2007 Dec;133(6):1999-2009. Epub 2007 Sep 14.In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia.Strobel O1, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Castillo CF, Warshaw AL, Thayer SP.Author information1Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.AbstractBACKGROUND & AIMS: Chronic injury results in regeneration of normal pancreatic tissue and formation of a metaplasia of ductal phenotype. Metaplastic ductal lesions are seen in pancreatitis as well as in specimens of pancreatic cancer and are thought to represent a condition with increased risk of neoplasia. Acinar-to-ductal transdifferentiation is thought to be the source of this metaplasia. This has been suggested for flat duct-like lesions called tubular complexes and for lesions exhibiting a mucinous metaplasia. However, available studies are based on interpretation of static data rather than on direct evidence. Transdifferentiation from acinar to ductal cells has never been confirmed in the adult pancreas.METHODS: Here, we use Cre-loxP-based genetic lineage tracing in vivo to investigate whether transdifferentiation of acinar cells contributes to regeneration and metaplasia in pancreatitis.RESULTS: The results show that transdifferentiation does not play a role in regeneration of normal tissue. Acinar cells are regenerated by preexisting acinar cells and not from other cell types. Three different types of metaplastic ductal lesions are observed and analyzed. Whereas the majority of metaplastic lesions are not of acinar origin, acinar-to-ductal transdifferentiation is identified in a minority of mucinous metaplastic lesions.CONCLUSIONS: Here, we provide direct evidence that acinar-to-ductal transdifferentiation occurs in the adult pancreas in vivo. However, it accounts for only a minority of metaplastic lesions.Comment inMetaplastic metamorphoses in the mammalian pancreas. [Gastroenterology. 2007]PMID: 18054571 PMCID: PMC2254582 DOI: 10.1053/j.gastro.2007.09.009 [Indexed for MEDLINE] Free PMC ArticleShareImages from this publication.See all images (6)Free textFigure 1Tagging in the ElastaseCreER™;Z/AP animal. Identification of HPAP by BCIP/NBT (blue) (A,C) and immunofluorescence (B,D). (A, B) HPAP is identified on the luminal membrane of acinar cells (arrowheads) and infrequently in islets (arrows) but not in the ductal epithelium (stars), including terminal ducts (arrowheads) and centroacinar cells (arrows) (C,D).In Vivo Lineage Tracing Defines the Role of Acinar-to-ductal Transdifferentiation in Inflammatory Ductal MetaplasiaGastroenterology. ;133(6):1999-2009.Figure 2New acinar cells are formed from preexisting acinar cells. (A) Stable percentage of tagged acinar cells independent of the duration of pancreatitis. (B) BrdU incorporation (brown). (C,D) Identification of HPAP activity, blue (C) and immunofluorescence (D). In CP acinar cell density is decreased but the percentage of HPAP+ acinar cells remains stable. HPAP is not identified in ducts (arrows in C,D). (E) BrdU incorporation, 2 hrs (red). In the normal pancreas (left panel), proliferative activity is identified in single differentiated acinar cells (arrowhead) expressing amylase (green). In response to inflammation (right panel), proliferation is frequently identified in acinar cells (arrowheads).In Vivo Lineage Tracing Defines the Role of Acinar-to-ductal Transdifferentiation in Inflammatory Ductal MetaplasiaGastroenterology. ;133(6):1999-2009.Figure 3TC1 are acinar cell-derived. (A) Quantitative analysis of lineage tracing. Expected and observed numbers of HPAP+ events. (B) Normal acinar cells and TC1 (arrows) are labeled with HPAP (blue). Unlabeled duct-like cells in TC1 (arrowheads). (C,D) TC1 express both HPAP (green) and amylase (red) (arrow in C) like acini (arrowheads). With loss of cytoplasm, amylase expression is downregulated but HPAP persists (arrows in D). (E,F) Double staining for HPAP (green) and CK (red) reveals that TC1 contain cells that are, like terminal ducts (star in E), strongly CK+ but never tagged with HPAP. A clear border (arrows) between CK+ cells and acinar-derived cells is maintained both in lesions with beginning luminar dilation (E) and with wide lumen (F).In Vivo Lineage Tracing Defines the Role of Acinar-to-ductal Transdifferentiation in Inflammatory Ductal MetaplasiaGastroenterology. ;133(6):1999-2009.Figure 4TC2 are not of acinar origin. (A) Quantitative analysis of lineage tracing. Comparison (*) of the number of expected HPAP+ events assuming acinar origin and the number of actually observed HPAP+ cells of ductal morphology. (B) HPAP activity (blue) is detected in acinar but not in duct-like cells within fields of TC and disappears with progressive loss of acinar cells. (C) The apoptosis marker cleaved caspase-3 (brown) is identified in acinar cells (arrowheads), but not in duct-like cells within fields of TC2. Fields without acinar cells are devoid of cleaved caspase-3 expression. (D) The epithelial lining of TC2 is not tagged with HPAP (green), but expresses the ductal marker CK (red). Note tagging of adjacent acinar cells (arrowheads). (E) Proliferation (BrdU-red) is frequently identified in CK+ (green) duct-like cells and occasionally in the stroma (arrowheads). (F) Hes-1 expression (brown). In controls, Hes-1 is identified in centroacinar cells (arrowheads), located near the acinar lumen (arrow) and in ductal cells (arrowhead, inset). In chronic injury, Hes-1 is almost always identified in centroacinar cells (arrows). Terminal ductal cells frequently express Hes-1 (arrowheads). TC2 mirror this expression pattern. Acini remain consistently negative for Hes-1.In Vivo Lineage Tracing Defines the Role of Acinar-to-ductal Transdifferentiation in Inflammatory Ductal MetaplasiaGastroenterology. ;133(6):1999-2009.Figure 5Acinar-to-ductal transdifferentiation accounts for a minority of MML. Separate analysis for lesions of mixed (A-C) and pure ductal phenotype (D-F). In most lesions mucinous metaplastic cells are not tagged with HPAP (B,E); In a minority of mixed and pure lesions HPAP+ ductal cells can be identified (C,F). Mixed phenotype: (A) Quantitative analysis reveals that HPAP is identified in cells of acinar morphology with a frequency similar to that expected for acinar origin. A minority (5.8%) of mixed lesions additionally contain HPAP+ mucinous cells of ductal morphology. (B) Mixed lesions, in which mucinous duct-like cells are not of acinar origin. HPAP/Alcian blue stains show that only acinar cells are tagged (blue), whereas mucinous metaplastic cells (turquoise) are untagged. Note that the lesion has formed in the terminal ductal to acinar region, whereas the draining duct (arrows) exhibits normal morphology. Serial double immunofluorescence identifies HPAP (green) in amylase+ cells (red, upper panel), but not in mucinous metaplastic cells, which are positive for both CK (red, mid panel) and gastric mucins (red, lower panel). Secreted amylase can be identified at the luminar membrane of the metaplastic ductal lining (arrowheads). (C) Mixed lesions with evidence of acinar-to-ductal transdifferentiation. Serial stains show expression of both HPAP (blue) and Alcian blue-positive mucins (turquoise) in cells of ductal morphology. Serial double immunofluorescence shows co-expression of HPAP (green) and amylase (red) in acinar cells (arrowhead), and confirm HPAP expression in duct-like cells without amylase expression (arrows, upper panel). These HPAP+ cells instead express both CK (red, middle panel) and gastric mucins (red, lower panel), suggesting transdifferentiation. Pure ductal phenotype: (D) In lesions of pure ductal phenotype HPAP+ duct-like cells are observed with a frequency (4.9%) similar to mixed lesions. (E) Most lesions (turquoise) are HPAP-. Double immunofluorescence confirms expression of HPAP (green, upper panel) in acini, but absence of HPAP in metaplastic lesions, which instead express gastric mucins (red, middle panel). There is no overlap between HPAP and mucin expression (lower panel). (F) Pure ductal lesions with evidence of acinar-to-ductal transdifferentiation: Serial stains show expression of both HPAP (blue) and Alcian blue-positive mucins (turquoise) in cells of ductal morphology. Double immunofluorescence of the same lesion confirms co-expression of HPAP (green) and the ductal marker CK (red).In Vivo Lineage Tracing Defines the Role of Acinar-to-ductal Transdifferentiation in Inflammatory Ductal MetaplasiaGastroenterology. ;133(6):1999-2009.Figure 6(A) MML exhibit a mosaic expression pattern of Hes-1 (brown). (B) Expression of Shh (brown) is frequently identified in MML. (C) Ki-67 expression (brown) and (D) incorporation of BrdU (green) demonstrate proliferative activity. (E) Apoptosis-cleaved caspase-3 (brown) is infrequently identified in MML.In Vivo Lineage Tracing Defines the Role of Acinar-to-ductal Transdifferentiation in Inflammatory Ductal MetaplasiaGastroenterology. ;133(6):1999-2009.Publication types, MeSH terms, Grant supportPublication typesResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tMeSH termsAnimalsCell Differentiation*Cell Lineage*Cell TransdifferentiationDisease Models, AnimalEpithelial Cells/pathology*InflammationMetaplasiaMicePancreas/pathology*Pancreas/physiologyPancreas, Exocrine/pathologyPancreatic Ducts/pathology*RegenerationGrant supportK08 DK071329/DK/NIDDK NIH HHS/United StatesK08 DK071329-04/DK/NIDDK NIH HHS/United StatesDK071329/DK/NIDDK NIH HHS/United StatesLinkOut - more resourcesFull Text SourcesElsevier ScienceClinicalKeyEurope PubMed Central - Author ManuscriptPubMed Central - Author ManuscriptPubMed Central Canada - Author ManuscriptOther Literature SourcesCOS Scholar UniverseMolecular Biology DatabasesKOMP RepositoryMouse Genome Informatics (MGI)PubMed Commons home


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3 bedroom terraced house for sale in Braunton Road, Aigburth, LIVERPOOL, Merseyside, L17
www.rightmove.co.uk/property/47411046
***Fully Available****
Abode are delighted to offer for sale this 3 bedroom terraced property - with original features - situated in the much sought after South Liverpool suburb of Aigburth. With local amenities in close proximity such as local shops, eateries, excellent transport links, a range of top quality schools and with the Otterspool promenade within easy walking distance, Braunton Road has much to offer the potential buyer. The property which is in need of some modernising briefly comprises an entrance hall, two reception rooms, morning room and kitchen. To the first floor there are three good sized bedrooms, and a family bathroom. Outside there is a court yard to the rear and area to the front with gated access. The property benefits from gas central heating, double glazing and is currently for sale with NO CHAIN. An internal inspection is HIGHLY RECOMMENDED.
Property ref: 121_2200_4377019
To view this media, please visit the on-line version of this page at www.rightmove.co.uk/property-for-sale/property-47411046.html?premiumA=true
Disclaimer - Property reference 4377019. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by Abode , Allerton. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.
24 Aug 2018 21 Braunton Road, L17 £240,000


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A Life of Her Own (Audiobook) by Fiona McCallum | Audible.com
By: Rosie Mackenzie
In stark contrast to her own childhood during the last days of the Raj in India, the spectacular beauty surrounding their home, Rathgarven in Ireland, has proven to be a happy place for Kathleen O'Sullivan and her husband, James, to raise their four children. But Kathleen is no stranger to heartbreak, and when the family is faced with losing everything, she knows they will need to adapt to survive. Even if that means leaving their beloved home and moving to Australia to start afresh.
By joan on 07-25-19
Four women, all at different stages of their life, are brought together as they overcome the challenges that life tends to throw in our way - and learn to embrace the surprises too, as each faces a second chance at happiness.
From Australia's master storyteller comes an inspiring story about standing up for yourself, making difficult choices and chasing your dreams.
When knowledge gives you the power to change your life....
Alice Hamilton loved being a mature-age student, but now she's finished her university degree she needs to find herself a career. But the job market is tough, and it doesn't help that her partner, David, keeps reminding her about their sizable mortgage. When she's offered a role in a major real estate agency, she jumps at the opportunity. David is excited by her prospects in the thriving Melbourne housing market, and Alice is pleased that she'll be utilising her exceptional people skills.
As everything starts to fall apart, a sudden visit home to the country town Alice escaped years ago provides an unexpected opportunity to get some perspective. Surrounded by people who aren't what they seem or have their own agendas, can Alice learn to ask for what she really wants...on her own terms?
©2019 Fiona McCallum (P)2019 Bolinda Publishing
The main character is always a victim, in every situation. She is so whiny and constantly complaining, and everyone she meets is a narcissist. The best was her horror over a guy getting frustrated with the xerox machine, she made it out to be like he held a knife to her throat. Then she was decimated by having to do an errand for her boss, and then she was destroyed that her boyfriend was aggravated that she kept quitting jobs. The story would have been far more credible if someone had eventually slapped her.
Loved it. Another great read by talented Austrian author. Can't wait for the next one

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BBC - Oxford Stage - review of Cooper! Jus' Like That Skip to main contentText only version of this pageAccess keys help HomeExplore the BBCThis page was last updated in March 2003We've left it here for reference.More information16 March 2014Accessibility helpText onlyBBC Homepage»BBC Local
Contact UsLike this page?Send it to a friend! March, 2003 Cooper tribute serves laughter on a plate
Jerome Flynn takes his hat off to Tommy Cooper at the Playhouse. Our critic marvels as the genius of Tommy Cooper is recreated on stage in Oxford - with a few dark moments amid the slapstick. SEE IT FOR FREE: BE A REVIEWER
SEE ALSO Theatre listings Director's notes WEB LINKS Apollo Theatre
View a printable version of this page. Cooper! Jus' Like That!
Oxford Playhouse By Richard Sanderson The opening scene was spectacular: 50s swing music echoed from the speakers as the shimmering curtain changed from silver to gold, to reveal a glitzy set and six tap-dancing girls clad in suspenders and white tails.
Into this cabaret, Tommy Cooper appeared balancing a stack of china plates.
Tommy Cooper was loved by TV audiences
He wobbled down the steps, plates crashing at his feet until the final fall sent the rest of the plates spilling into the audience. Several (paper) plates actually landed on front row heads, mine included. And so began the laughter.
King of the one-liner, the bum joke that your dad mimics at Christmas and the magic trick that doesn�t go to plan, Cooper is a legend among comedians.
Jerome Flynn, as Cooper, has the magician's acute sense of timing.
His mannerisms allow you to believe that this is the real thing - that wide smile, the splay of the hands and the ability to laugh, on stage, at his own jokes.
In the first half the author, John Fisher, takes the audience from a rapid succession of one-liners and magical mishaps to Cooper�s dressing room, and the darker, autobiographical side of the comedian�s life. Here the director, Simon Callow, slows the pace of the play as the comedian takes to smoking cheroots and drinking hard liquor while reflecting on his loves, insecurities and flaws. At this point, to my mind, it feels too slow and although the audience is provoked to think about the sadness and pitfalls of an entertainer�s life, you long to be engaged and your spirits lifted. The second half is devoted solely to Cooper�s stand-up performance. Gag after gag and failed magic tricks provoke a unison of giggles and jaw-dropping suspense from the onlookers. Behind me, amid the laughter, people comment on the props they love - the flower that grows with a tincture of water or the white gate with no purpose except to walk through. Flynn is superb throughout.
The crescendo of hilarity reaches its peak with a recital of New Year's Eve, a poem involving a soldier, a sailor, a fireman and a tramp, which Cooper acts out aided solely by hats. On reflection, the low point in the play, that of Cooper�s off-stage more troubled life, helps to emphasise his comic genius.
This play is a tour de force. I was stunned.
If you are young, let a big man in a fez make you laugh; and if you are older, revisit some timeless entertainment of your youth. Time: 19:30 (20:00 on Friday)
Thur and Sat mats 14:30
Tickets £12.50-£24 Click here for Oxford Playhouse details

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Tottenham 3-2 Arsenal: U23 Premier League report | Daily Mail Online
Tottenham 3-2 Arsenal: Marcus Edwards converts penalty to settle under-23 North London derby
Tottenham beat North London rivals Arsenal 3-2 in Premier League 2 fixtures
Spurs made a blistering start with goals from Shayon Harrison and Samuel Shashoua inside the first 11 minutes
But the Gunners fought back and pulled level thanks to Tyreece John-Jules and a penalty from Charlie Gilmour
But Marcus Edwards scored the winner from the spot on the hour mark
Published: 09:53 EDT, 23 October 2017 | Updated: 09:54 EDT, 23 October 2017
Playing on their training ground near Enfield, Spurs stormed into a two-goal lead inside 10 minutes thanks to strikes from Shayon Harrison and Samuel Shashoua.
But the young Gunners fought back before half-time in the Premier League 2 fixture with 16-year-old Tyreece John-Jules halving the deficit and Charlie Gilmour blasting home a penalty.
Marcus Edwards converted the decisive penalty as Tottenham beat Arsenal 3-2 on Monday
England under-20 international Edwards settled the under-23 North London derby
Samuel Shashoua celebrate after scoring Tottenham's second goal during an early blitz
Arsenal get back to work following Everton victory as Arsene... Tottenham boss Mauricio Pochettino lifts lid on Kyle Walker... Cheeky ball boys, another Alexis Sanchez tantrum and Tony... Harry Kane sets sights on emulating goal feats of Cristiano...
However, with first-team manager Mauricio Pochettino watching intently from the sidelines, England under-20 international Marcus Edwards scored from the 12 yards to lift Spurs out of the relegation zone.
Spurs flew out of the blocks and led after only 10 minutes when Edwards found Harrison, who controlled well and fired home off the post.
And things would get better for the hosts almost immediately when Shashoua seized upon a loose ball inside the Arsenal box following a mistake to fire home.
Arsenal recovered their composure well, however, and equalised on the quarter-hour when John-Jules tucked home from a corner after Gilmour had struck the crossbar seconds earlier.
Shayon Harrison celebrates with his Tottenham team-mates after opening the scoring
Tyreece John-Jules started Arsenal's fightback when he fired home on 15 minutes
Charlie Gilmour (No 8) celebrates with team-mates after converting a penalty to make it 2-2
Gilmour fires the penalty past Tottenham goalkeeper Alfie Whiteman to level the scores
Tottenham Hotspur: Whiteman; Bennetts, Marsh, Tanganga, Maghoma; Amos (c), Skipp; Georgiou (Sterling 56), Shashoua (Pritchard 72), Edwards; Harrison (Loft 82)
Substitutes not used: Austin (GK); Roles
Scorers: Harrison 10; Shashoua 11; Edwards 60 pen
Booked: Maghoma, Shashoua, Amos, Marsh
Arsenal: Virginia; Moore, Olowu, Medley (c), Bola; Dragomir, Eyoma; Pleguezuelo, Gilmour, John-Jules (Omole 74); Balogun
Substitutes not used: Keto (GK); Clarke, Swanson, Benson
Scorers: John-Jules 15; Gilmour 24 pen
Booked: Bola, Pleguezuelo, Gilmour, Dragomir
And they were level by the 24th minute, with Japhet Tanganga adjudged to have handled as he headed the ball down inside the box and Gilmour making no mistake.
The two sides traded chances in an end-to-end game, with John-Jules denied by a Christian Maghoma block and Harrison curling a shot just off target.
Arsenal might have completed their comeback early in the second-half but Spurs keeper Alfie Whiteman denied John-Jules and Tanganga then dived in to block Folarin Balogun's shot towards the empty net.
But the decisive moment came on the hour mark, when Kaziah Sterling was tripped by Joseph Olowu inside the area and Edwards converted the spot-kick.
Arsenal exerted late pressure in search for an equaliser but Spurs might have added a fourth when Oliver Skipp broke clear, only for Tolaji Bola to slide in to thwart him.
It meant Arsenal remain third in the standings and missed the chance to close the gap on leaders Everton.
Arsenal forward Folarin Balogun heads towards goal in a congested penalty area
Arsenal's Aaron Eyoma and Tottenham's Anthony Georgiou compete for the ball
Marcus Edwards uses his speed to get round Arsenal's Zech Medley
Oliver Skipp of Tottenham and Vlad Dragomir of Arsenal contest the ball

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9787511336002 - Collected Works of Forest Newsaper Chinese Edition by Vitali Bianchi - AbeBooks
9787511336002 - Collected Works of Forest Newsaper Chinese Edition by Vitali Bianchi
ISBN: 9787511336002
Super color Museum: Forest Report Collection ( Value Platinum Edition full color )(Chinese Edition)
WEI TA LI BI AN JI
ISBN 10: 7511336000 ISBN 13: 9787511336002
About this Item: Hardcover. Condition: New. Ship out in 2 business day, And Fast shipping, Free Tracking number will be provided after the shipment.HardCover. Pub Date :2013-08-01 Pages: 411 Language: Chinese Publisher: China Overseas Press super color Museum: Forest Report Collection ( Value Platinum Edition full color ) from 1924 to 1925 . Bianchi began The new Robinson magazine column written description of forest life . and gradually formed a newspaper features. This is the Forest News prototype. In 1927. the Forest News compiled and published . there was this in the world of children's literature occupies a unique position in the cl.Four Satisfaction guaranteed,or money back. Seller Inventory # BR059523

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A companion to Plato's Republic for English readers : Bosanquet, Bernard, 1848-1923 : Free Download & Streaming : Internet Archive
A companion to Plato's Republic for English readers
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Graphic Violence Graphic Sexual Content Spam, Scam or Fraud Broken or Empty Data textsA companion to Plato's Republic for English readers by Bosanquet, Bernard, 1848-1923 Published 1895
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A companion to Plato's Republic for English readers Oct 6, 2009
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A companion to classical texts Aug 20, 2008

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The Publican's Handbook: Amazon.co.uk: Danny Blyth: 9780749435080: Books
Danny Blyth (Editor)
Pubs Bars and Clubs Handbook
Running a pub is an increasingly complex business. The publican now needs to embrace a broad range of management responsibilities in the pursuit of competitive advantage. Now in its third edition, The Publican's Handbook provides, in a concise and accessible form, a complete management toolkit for both publicans and marketing and operations managers of the big chains to help them acquire the marketing, financial and management skills necessary to gain a competitive edge. The handbook gives guidance on everything from raising finance and managing staff, to long-term strategic planning and stock control. An essential guide for any modern publican and those in the pub markets.
Publisher: Kogan Page Ltd (London); 4th Revised edition edition (Feb. 2001)
ISBN-10: 0749435089
ISBN-13: 978-0749435080
Amazon Bestsellers Rank: 8,361,576 in Books (See Top 100 in Books)

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