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Eric Decker signs with Tennessee without any public interest from Minnesota Vikings - Cincinnati - Scout
Share on Facebook Share on TwitterTrending on ScoutOhio D-Tackle Earns Irish OfferWeekend Feature-Attack Missions in-B-2 BomberIowa Takes Another Step Forward With BrentsRosso Sees Red, Commits to RutgersReport: Michigan Big Man CampBengals Insider Top Stories2017 Cincinnati Bengals Team OutlookSenior Fantasy Football Expert Shawn Childs goes in-depth covering every Fantasy aspect of the 2017 Cincinnati Bengals!by Shawn ChildsScout FantasyMonday at 5:57 AMBreaking NewsState's top defender Armour-Davis to AlabamaJalyn Armour-Davis had been back and fourth between Alabama, Auburn and Florida State this year but elected to go public between the three on Friday.by John Garcia, Jr.BamaMagYesterday at 11:07 AMDynasty Football: Dr. Roto's Rookie DraftDr. Roto is counting down the hours until his SiriusXM Hosts Dynasty Rookie Draft! After acquiring two picks in the first round, Doc breaks down the pros and cons of each player he…by Dr. RotoScout FantasyWednesday at 10:30 AMJohn Ross finds a home with CincinnatiWashington junior receiver John Ross, who made a name for himself forever by running the fastest recorded 40 time in NFL Combine history, was taken by the Cincinnati Bengals with…by Site StaffDawgman.com04/27/20172017 New England Patriots Team OutlookSenior Fantasy Football Expert Shawn Childs goes in-depth covering every Fantasy aspect of the 2017 New England Patriots!by Shawn ChildsScout FantasySunday at 12:40 PMFilm Room: How Ray Can Replace WareDeMarcus Ware called it a career, but the Broncos had the foresight to prepare a worthy replacement in Shane Ray.by Will KeysMile High Huddle06/16/2017Rams trade Greg Robinson to LionsLos Angeles has dealt away the former first-round pick to the Lionsby Bob Garcia IVLA Rams Report06/15/2017Broncos Waive 2015 7th-Rounder Taurean NixonA bit of reshuffling gives the Broncos a new face at corner.by Will KeysMile High Huddle06/14/2017"Beat Lisa Ann" Fantasy Draft BreakdownSenior Fantasy Football Expert Adam Ronis breaks down the "Beat Lisa Ann" Fantasy Football Draft-N-Go that he participated in on Sunday night. In this article, Ronis discusses…by Adam RonisScout Fantasy06/13/2017Toledo Still Sticking Out for TE TorresAnthony Torres is becoming a hot commodity in the 2018 recruiting class at the tight end position. Yet, Jason Candle and his staff rank highly for the current three-star.by Zach HarigRocket Digest06/12/2017Top-100 DE Tyreke Smith Planning Many VisitsTyreke Smith is one of the top 2018 defensive end prospects in America, and the four-star recruit has an ambitious summer visit schedule planned.by Bill GreeneScout Football06/03/20172017 UCLA Opponent Primer: WashingtonJun. 2 -- We take a look at Washington, which loses a lot defensively but should still be one of the main contenders in the Pac-12...by David WoodsBruin Report Online06/02/2017Load More


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Patent US5482989 - Calcium pyroborate as a microbicide for plastics - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe use of calcium pyroborate to protect plastic materials from microbiological, growth, attack, or degradation, is described. The calcium pyroborate may be modified to reduce its solubility in water and provide longer microbicide effectiveness....http://www.google.com/patents/US5482989?utm_source=gb-gplus-sharePatent US5482989 - Calcium pyroborate as a microbicide for plasticsAdvanced Patent SearchPublication numberUS5482989 APublication typeGrantApplication numberUS 08/293,217Publication dateJan 9, 1996Filing dateAug 19, 1994Priority dateAug 19, 1994Fee statusLapsedAlso published asCA2197779A1, CA2197779C, CN1098301C, CN1155892A, EP0776347A1, WO1996006130A1Publication number08293217, 293217, US 5482989 A, US 5482989A, US-A-5482989, US5482989 A, US5482989AInventorsMark S. KoskiniemiOriginal AssigneeBuckman Laboratories Internationa, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (3), Referenced by (11), Classifications (17), Legal Events (6) External Links: USPTO, USPTO Assignment, EspacenetCalcium pyroborate as a microbicide for plastics
US 5482989 AAbstract
The use of calcium pyroborate to protect plastic materials from microbiological, growth, attack, or degradation, is described. The calcium pyroborate may be modified to reduce its solubility in water and provide longer microbicide effectiveness.
1. A plastic article formed from a plastic comprising a plastic premix and a microbicidally effective amount of calcium pyroborate.
2. A plastic article of claim 1, wherein the calcium pyroborate is modified to reduce its solubility.
3. A plastic article of claim 1, wherein the plastic is a thermoplastic, a thermoset, or a composite material.
4. A plastic article of claim 2, wherein the plastic comprises a resin and the calcium pyroborate is a silica-coated calcium pyroborate and is present in an amount of 0.01 to 25 parts per hundred parts resin.
5. A plastic article of claim 4, wherein the silica-coated calcium pyroborate is present in an amount of 1 to 10 parts per hundred parts resin.
6. A plastic article of claim 4, wherein the plastic is polyvinyl chloride or polyurethane.
7. A plastic article of claim 1, wherein the plastic comprises a resin and the calcium pyroborate is present in an amount of 0.01 to 25 parts per hundred parts resin.
8. A plastic article of claim 1 wherein the plastic material is a shower curtain, a waterbed mattress, a siding for a building, a swimming pool liner, a countertop, a pipe, a roofing membrane, packaging material, a soap dish, a wallpaper or plastic fencing material.
9. A process for protecting a plastic article from microbiological attack comprising:incorporating a microbicidally effective amount of calcium pyroborate into a plastic premix and forming the premix into said plastic article. 10. The process of claim 9, wherein the calcium pyroborate is incorporated into a dry plastic premix or into a melt stage of a plastic premix.
11. The process of claim 10, further comprising, before the forming step, the step of heating the plastic premix prior to forming.
12. The process of claim 10, wherein the plastic is formed by curing, injection molding, extrusion, calendering, blowing, or compression.
13. The process of claim 9, wherein the calcium pyroborate is modified to reduce its solubility.
14. The process of claim 13, wherein the calcium pyroborate is a silica-coated calcium pyroborate.
15. The process of claim 12, wherein the plastic is a thermoplastic, a thermoset, or a composite.
16. The process of claim 12, wherein the plastic premix comprises a resin and the calcium pyroborate is a silica-coated calcium pyroborate and is incorporated in an amount of 0.01 to 25 parts per hundred parts resin.
17. The process of claim 16, wherein the calcium pyroborate is present in an amount of 1 to 10 parts per hundred parts resin.
18. The process of claim 16, wherein the plastic premix comprises a polyvinyl chloride resin or a polyurethane resin.
19. The process of claim 11, wherein the plastic premix comprises a resin and the calcium pyroborate is a silica-coated calcium pyroborate and is present in an amount of 0.01 to 25 parts per hundred parts resin.
20. The process of claim 10, wherein the plastic premix comprises a resin and the calcium pyroborate is a silica-coated calcium pyroborate and is present in an amount of 0.01 to 25 parts per hundred parts resin.
21. The plastic article of claim 1, wherein said plastic premix is a plastic resin.
This invention relates to a plastic material containing a microbicidally effective amount of calcium pyroborate and a process for protecting a plastic material from microbiological attack.
Microbiological fouling of plastic materials is an unwanted nuisance and a problem in many household and industrial environments. The humid and high moisture environments where plastic materials are often used provide excellent growth environments for unwanted microorganisms such as mold, fungi, and mildew. In addition to degrading and fouling plastic materials, these microorganisms can cause unsightly stains and unpleasant odors.
The plastics industry has used various microbicides to prevent the growth of microorganisms on plastic materials. U.S. Pat. Nos. 4,086,297 and 5,270,108 provide a discussion of the use of microbicides with plastics. Barium metaborate is an example of a microbicide used in a wide variety of plastics. OBPA, Oxy-Bis-Phenoxy-Arsine, the most commercially significant microbicide, is found in a wide range of plastic consumer goods such as waterbed mattresses and shower curtains.
As environmental concern has increasingly focused on contaminants introduced into groundwater, regulatory scrutiny has also focused on the disposal of many materials and products including plastics. Regulatory authorities have discouraged or even regulated the use of acute human toxicants and carcinogenic materials. Thus, the plastics industry has been looking for environmentally favorable biocides.
The plastics industry places strict physical requirements on microbicides for use in plastic materials. The microbicide should be temperature and pressure stable. It should have limited solubility in water to perform as a long term microbicide of a plastic article. For exterior applications where the plastic material is exposed to the environment, the microbicide should also have significant ultraviolet radiation stability. Thus, there remains a need for an effective biocide which is useful with plastic materials and articles and meets the strict requirements of the plastics industry.
The present invention is directed to a plastic material comprising plastic and a microbiocidally effective amount of calcium pyroborate. The present invention is also directed to a process for protecting a plastic material from microbiological attack. The process includes the steps of incorporating a microbiocidally effective amount of calcium pyroborate into a plastic premix and forming the premix into a plastic.
In one embodiment, the present invention relates to a plastic material comprising plastic and a microbiocidally effective amount of calcium pyroborate. The plastic may be any plastic material including plastic articles, surfaces, coatings fabrics, etc. Calcium pyroborate has been found to be useful as an effective microbicide for a variety of plastics. Advantageously, calcium pyroborate meets the strict requirements placed on microbicides by the plastic industry.
Calcium pyroborate possesses numerous advantages relative to current microbicides used with plastic materials or articles. First, calcium is not regulated as a hazardous material. Second, calcium pyroborate is stable to environmental conditions, such as ultraviolet radiation and heat. Third, calcium pyroborate is not expected to be an acute human toxicant or carcinogen. The EPA has recently stated that, based on a review of toxicology data, boric acid and its salts are benign. Fourth, calcium pyroborate is also compatible with other additives commonly used in plastics. Finally, calcium pyroborate should provide flame retardant activity similar to biocides such as barium metaborate, resulting in a potential added industrial value.
More advantageously, calcium pyroborate has shown significant efficacy in protecting plastic from microbiological growth, attack, fouling and degradation. Calcium pyroborate is efficacious at or below concentrations commonly used for other known microbicides. For example, a plastic material may contain calcium pyroborate in an amount of 0.01 to 25 parts per 100 parts plastic. Where the plastic material is formed from a plastic resin, the amount of calcium pyroborate used is preferably based on the amount of resin in the plastic material. Thus, for example, preferably, the calcium pyroborate is present from 0.5 to 15 parts per 100 parts resin, more preferably 1 to 5 parts per 100 parts resin, and most preferably 2 parts per 100 parts resin. The amount of calcium pyroborate employed may also relate to the severity of the environment into which the plastic is put and to the expectations for microbicide performance. For more severe environments, higher amounts of calcium pyroborate may be used.
A drawback to some current microbicides is their relatively high water solubility. This causes the microbicide to leach out of the plastics and results in the loss of the desired microbicidal protection for the plastic material or article. The toxicity of some microbicides may also be related to their water solubility and subsequent leaching from the plastic material. Consequently, modifying the solubility of a microbicide to reduce its water solubility would increase its safety, effectiveness and provide for longer lasting biocidal activity.
A further embodiment of this invention, therefore, relates to the use of modified calcium pyroborate as a microbicide for plastic materials. Modified calcium pyroborate is any form of calcium pyroborate modified to reduce its solubility in water below that of calcium pyroborate itself.
The degree of modification can be chosen to meet the requirements for the desired level of protection for a given plastic. For example, where the plastic is a one-time-use article, the calcium pyroborate may be used without modification or with only slight modification. Not, or only slightly, decreasing its water solubility would increase the amount of calcium pyroborate available to protect the plastic. Where the plastic is used repeatedly or over a longer time period, the calcium pyroborate can be modified to a greater extent to decrease or eliminate any leaching from the plastic.
An advantage of the present invention is that calcium pyroborate as a microbicide, due to its heat stability, is not expected to interfere with a plastic recycling process. Given the environmental safety of calcium pyroborate, recycling plastic containing calcium pyroborate also should not introduce any toxic or offensive components into the recycling system. Advantageously, its stability would ensure that a recycled plastic may, to some extent, have the same biocidal capabilities as an original plastic.
The calcium pyroborate can be modified by any method known to decrease its water solubility. Such methods include, but are not limited to, treating, mixing, or reacting calcium pyroborate particles or powder with other materials. Such methods or treatments also keep the calcium pyroborate from having unacceptable handling characteristics such as agglomeration upon storage, etc.
One method of modifying calcium pyroborate to reduce its water solubility is described in U.S. Pat. No. 5,066,334 to Pera et al. The disclosure of that patent is incorporated here by reference and in its entirety. The modified calcium pyroborate described by Pera et al. is a silica-coated calcium pyroborate pigment in particulate form. The water solubility of the calcium pyroborate is decreased by increasing the amount of silica used to coat the calcium pyroborate.
The water solubility of unmodified calcium pyroborate is approximately 1800 ppm. The solubility may be reduced to as low as 600 ppm with a silica treatment of 21% by weight of the calcium pyroborate. Such a solubility level may require a co-biocide to provide protection in the short term. The co-biocide could, for example, be unmodified calcium pyroborate or another known microbicide mixed in with the modified calcium pyroborate. Preferably, the water solubility of the silica coated calcium pyroborate ranges from 1000 ppm to 1300 ppm.
The product BL-1227 is a preferred silica-coated calcium pyroborate pigment having a water solubility of 1300 ppm. BL-1227 product is available from Buckman Laboratories, Inc., Memphis, Tenn.
Calcium pyroborate, modified or unmodified, may be used with a variety of plastics, including but not limited to thermoplastics, thermosets, or engineered materials, i.e., composites. Preferably the plastic resin used is polyvinyl chloride, polyethylenes, or polyurethane. According to the invention, the term plastic includes, but is not limited to, any plastic material, article, good, surface, fabric, sheet, etc. For example, plastics include shower curtains, waterbed mattresses, siding for homes, liners for swimming pools, roofing membranes, packaging materials, and any variety of household or industrial items used in a moist, humid environment, e.g., soap dishes, countertops, wallpapers for bathrooms and kitchens, plastic fencing material.
Generally, the calcium pyroborate is added or incorporated like or with any other additive to the plastic resin, polymer or other plastic material being used to form a plastic premix. Preferably, the plastic premix is a mixture of plastic resin beads or chips and may contain other conventional additives. The incorporation can be done, for example, in a dry mix or a melt stage. In a melt stage, the premix material is in a pseudo-liquid state where mixing will achieve the greatest degree of uniform dispersion of the calcium pyroborate throughout the plastic.
Anhydrous calcium pyroborate, modified calcium pyroborate, as well as hydrated calcium pyroborate are generally available in particulate or powder forms. The calcium pyroborate may be incorporated into the plastic premix not only as a particle or powder but also as a slurry or dispersion. When using hydrated calcium pyroborate, a slurry or dispersion of calcium pyroborate, the amount of water or other liquid should not be so much as to adversely affect the plastic, its formation, or other processing.
After incorporating the calcium pyroborate into the plastic premix, the premix is then formed into a plastic for further work or as a finished product. The plastic may be heated prior to or during the forming step. Depending on the curing times for the plastic or the finished product, the mixture may be cured, injected into a mold, extruded, calendered, blown, compressed, or otherwise formed or fabricated by means known in the art.
Another embodiment of the invention, then, is a process for protecting a plastic material from microbiological attack. The process includes the steps of incorporating a microbiocidally effective amount of calcium pyroborate into a plastic premix and forming the premix into a plastic.
In order to further disclose the nature of the present invention the following examples illustrate the present invention. All ratios referred to are to be measured in parts by weight. It is to be understood that the invention is not to be limited to the specific conditions or details set forth in these examples except insofar as such limitations are specified in the appended claims.
Test samples based on a typical plasticized polyvinyl chloride (PVC) formulation, i.e., 40 parts plasticizer (dioctylphthalate (DOP)) per hundred parts resin, were made up using the biocides listed below in Table 1. Each biocide, used at 2 parts per hundred parts resin, was dry blended with PVC beads. The mixture was melted and then pressed into sheets.
TABLE 1______________________________________Sample Biocide______________________________________A)    modified calcium pyroborate, BL-1227 productB)    90% barium metaborate pigment product, Busan 11M1 product, Buckman Laboratories, Inc., Memphis, Tenn.C)    talc filler (control)D)    colemanite (control)E)    20% active 2-(Thiocyanomethylthio)benzothiazole on a solid support, BL-1222 product, Buckman Laboratories, Inc., Memphis, Tenn.______________________________________
Resistance to the Growth of Mold
The resistance to the growth of mold of test samples prepared according to Example 1 was determined using the testing procedure described in ASTM D-3273-82T. ASTM D-3273-82T evaluates a material's resistance to the growth of mold that might occur in a severe mold environment.
The testing device was an environmental chamber kept at a constant temperature of 90� �2� F. and a relative humidity of 95 to 98%. Within the chamber were dirt boxes containing soil inoculated with the following known organisms: Aspergillus niger, Aspergillus oryzae, and an unknown species of Penicillium.
Prior to exposure in the environmental chamber, however, the samples were exposed to a cycle of UV light (4 hours) and condensation (4 hours, no UV) for a total test period of 200 hours. This was to check the UV and moisture resistance of the test materials relative to a known barium metaborate standard product, Example 1B. Barium metaborate is resistant to UV and moisture deactivation and is known to provide a UV-stabilizing effect to PVC materials. Samples A, B, C, and D yellowed slightly as a result of this exposure, and comparative sample E yellowed badly.
Test panels, 3�5 inches and 0.025 inch thick, were hung vertically in the environmental chamber, with the bottom of each panel approximately three inches above the surface of the inoculated soil. Sufficient spacing was left to allow circulation of air and to prevent contact between samples or with wall surfaces. The samples were held in the chamber for 2 months.
The test samples were evaluated according to ASTM D-3274 using photographic reference standards that provide a numerical basis for rating the degree of fungal growth or soil and dirt accumulation on paint films. The numerical basis ranges from zero to ten. Ten indicates an absence of mold growth. A rating of eight signifies slight amount of mold growth. A rating of six signifies medium growth. A rating of four indicates heavy growth, two indicates very heavy growth, and zero indicates complete coverage. Ratings of five or less are usually considered failing scores. The results are shown in Table 2.
TABLE 2______________________________________   Sample         Rating______________________________________   A     9   B     10   C     5   D     5-6   E     8-9______________________________________
Determining Resistance of Synthetic Polymeric Materials to Fungi
One inch square test samples prepared according to Example 1 were placed onto mycophil agar plates. The surface of the agar and test samples were inoculated with a fungal spore suspension of Aspergillus niger. The plates were incubated 21 days at 30� C. Examination of the plates revealed the results shown in Table 3.
The rating basis is a visual inspection to the following scale. A rating of zero indicates no growth. A rating of one indicates growth covering less than 10% of the test sample, two (10-30% coverage), three (30-60% coverage), and four (60-100% coverage). See ASTM G-21.
TABLE 3______________________________________Sample    Rating (average of three values)______________________________________A         1.0B         3.0C         2.3D         2.3E         1.0______________________________________
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4086197 *Jun 21, 1976Apr 25, 1978Societe Chimique Des CharbonnagesHardeners for epoxy resinsUS5066334 *Dec 19, 1989Nov 19, 1991Buckman Laboratories International, Inc.Fungicidal and corrosion inhibiting paint pigmentsUS5270108 *Dec 28, 1989Dec 14, 1993Afm CorporationBuilding material with protection from insects, molds, and fungi* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS6017561 *Apr 4, 1997Jan 25, 2000The Clorox CompanyAntimicrobial cleaning compositionUS6039964 *Apr 11, 1997Mar 21, 2000Omni Manufacturing, Inc.Germicidally protected conveyor componentsUS6080387 *Jul 15, 1998Jun 27, 2000The Clorox CompanyAerosol antimicrobial compositionsUS6180039Jul 30, 1999Jan 30, 2001Rainbow Industrial Products Corp.Germicidally protected conveyor components and methods for their productionUS6241091 *Apr 6, 1999Jun 5, 2001Gregory MooreDecorative container for storing plungerUS6270754Jul 1, 1999Aug 7, 2001The Clorox CompanyAntimicrobial cleaning compositionUS6284814Aug 31, 1998Sep 4, 2001Chakra V. GuptaMethod of making masterbatches of liquid additives and, in particular, antimicrobial masterbatchesUS6328985Jul 30, 1999Dec 11, 2001Ram Belts & Chains, Inc.Germicidally protected conveyor componentsUS6482392Jun 23, 2000Nov 19, 2002The Clorox CompanyAerosol antimicrobial compositionsUS6653524Dec 4, 2000Nov 25, 2003Kimberly-Clark Worldwide, Inc.Nonwoven materials with time release additivesUS7883651 *Oct 8, 2003Feb 8, 2011Lords Additives LLCLignoellulosic, borate filled, thermoplastic composites* Cited by examinerClassifications U.S. Classification524/404, 524/436, 523/122, 524/405, 523/216, 523/210International ClassificationC08L101/00, C08K9/02, C08L27/06, B65D81/28, A01N59/14, C08K3/38, C08L75/04Cooperative ClassificationC08K9/02, C08K3/38European ClassificationC08K9/02, C08K3/38Legal EventsDateCodeEventDescriptionMar 9, 2004FPExpired due to failure to pay maintenance feeEffective date: 20040109Jan 9, 2004LAPSLapse for failure to pay maintenance feesJul 30, 2003REMIMaintenance fee reminder mailedJun 25, 1999FPAYFee paymentYear of fee payment: 4Jul 23, 1996CCCertificate of correctionOct 3, 1994ASAssignmentOwner name: BUCKMAN LABORATORIES INTERNATIONAL, INC.Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:KOSKINIEMI, MARK S.;REEL/FRAME:007152/0931Effective date: 19940913RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services

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Mr and Mrs Mr and Mrs Sign Mr and Mrs Wall Decal bedroom | Etsy
Mr and Mrs Wall Decal - This design is so elegant and makes a great statement in a master bedroom. It will be the perfect finishing touch to your bedroom decor!
*What size will work best above my bed?* Our best recommendation to determine what size will work best is to measure the width of your bed. To make the decal a subtle accent in your room, choose a size smaller than the width of your bed. To make a large statement, choose a size the same size or larger than the width of your bed.
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James Corden apologizes for Harvey Weinstein jokes | Daily Mail Online
'Sexual assault is no laughing matter': James Corden apologizes for Weinstein gags at Hollywood gala after huge online backlash and says he was just trying to shame disgraced movie mogul
Corden has now apologized for his jokes and said: 'I was not trying to make light of Harvey’s inexcusable behavior, but to shame him, the abuser, not his victims'
Published: 16:44 EDT, 15 October 2017 | Updated: 06:30 EDT, 17 October 2017
He wrote in two Tweets: 'To be clear, sexual assault is no laughing matter. I was not trying to make light of Harvey’s inexcusable behavior, but to shame him, the abuser, not his victims. I am truly sorry for anyone offended, that was never my intention.'
His apology comes after he was condemned on social media for jokes he made at the amfAR Gala, which he hosted, in Los Angeles on Friday night. The audience of A-listers reacted to his jokes with a mixture of groans and applause.
Pictured: James Corden is spotted out and about in Santa Monica with his son Max hours after his public apology on twitter for making jokes relating to Harvey Weinstein
James Corden has apologized for jokes, which were ill-received on social media, that he made about Harvey Weinstein at the amFAR gala in Los Angeles
Corden hosted the amFAR gala in Los Angeles on Friday night and made multiple jokes about the sexual harassment allegations swirling around former movie mogul Harvey Weinstein

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Expression of an additional cathelicidin antimicrobial peptide protects against bacterial skin infection. - PubMed - NCBI
1 selected item: 15728389
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3750-5. Epub 2005 Feb 22.
Lee PH1, Ohtake T, Zaiou M, Murakami M, Rudisill JA, Lin KH, Gallo RL.
Division of Dermatology, University of California at San Diego, San Diego, CA 92161, USA.
Cathelicidin antimicrobial peptides are effectors of innate immune defense in mammals. Humans and mice have only one cathelicidin gene, whereas domesticated mammals such as the pig, cow, and horse have multiple cathelicidin genes. We hypothesized that the evolution of multiple cathelicidin genes provides these animals with enhanced resistance to infection. To test this, we investigated the effects of the addition of cathelicidins by combining synthetic cathelicidin peptides in vitro, by producing human keratinocytes that overexpress cathelicidins in culture, or by producing transgenic mice that constitutively overexpress cathelicidins in vivo. The porcine cathelicidin peptide PR-39 acted additively with human cathelicidin LL-37 to kill group A Streptococcus (GAS). Lentiviral delivery of PR-39 enhanced killing of GAS by human keratinocytes. Finally, transgenic mice expressing PR-39 under the influence of a K14 promoter showed increased resistance to GAS skin infection (50% smaller necrotic ulcers and 60% fewer surviving bacteria). Similarly constructed transgenic mice designed to overexpress their native cathelicidin did not show increased resistance. These findings demonstrate that targeted gene transfer of a xenobiotic cathelicidin confers resistance against infection and suggests the benefit of duplication and divergence in the evolution of antimicrobial peptides.
15728389
PMC549293
10.1073/pnas.0500268102
PR-39 enhances killing of GAS by mCRAMP. The antimicrobial activity of PR-39 and mCRAMP was evaluated by solution killing assay. GAS was incubated with increasing concentrations of PR-39 and 0 μM (•), 1 μM (▴), 4 μM(▪), and 8 μM(♦) mCRAMP. (A) Bacterial counts decreased when GAS was incubated with the combination of PR-39 and mCRAMP. (B) CFU determination shows a corresponding decrease in live bacteria. Data shown are means (±SD) from triplicate determination representative of two independent experiments.
Expression of an additional cathelicidin antimicrobial peptide protects against bacterial skin infection
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3750-3755.
Lentiviral delivery of PR-39 to HaCaT cells confers antimicrobial activity. (A) RT-PCR analysis for the presence of full-length or mature PR-39 mRNA in transduced cells. Lanes: 1, negative control (HaCaT cells, no transduction); 2, full-length PR-39-transduced HaCaT cells (450-bp product); 3, mature PR-39-transduced HaCaT cells (120-bp product). Expression of cathelicidins in HaCaT cells was verified 72 h after infection with viral particles. (B) Ex vivo assessment of cathelicidin-mediated killing of bacteria by PR-39-expressing HaCaT cells. Cell lysates prepared from pLV/LacZ-, pLV/FL-PR-39-, or pLV/PR-39-infected HaCaT cells were incubated overnight with GAS NZ131. Antimicrobial activity of each construct against GAS was determined by CFU counts. Data shown are means(±SD) of six samples and are representative of two independent experiments.
Construct of K14-Cath-PR-39 and K14-Cath-mCRAMP transgenic mice. (A and B) Schematic representation of the K14-Cath-PR-39 (A) and K14-Cath-mCRAMP (B) transgene constructs. RT-PCR analysis was performed on total RNA extracted from skin of adult mice. S.S., signal sequence. (C) RT-PCR analysis verifying PR-39 transcription. Lanes: 1, DNA marker; 2, 5, and 8, wild-type littermate; 3, 6, 9, and 4, 7, and 10, two different founder K14-PR-39 transgenic mice, respectively; 2–4, β-actin amplification; 5–7, PR-39 amplification without reverse transcriptase reaction; 8–10, PR-39 amplification. (D) RT-PCR analysis verifying mCRAMP transcription. Lanes: 1, DNA marker; 2, 5, and 8, and 3, 6, and 9, and 4, 7, and 10, three different founder K14-mCRAMP transgenic mice, respectively; 2–4: β-actin amplification; 5–7, mCRAMP amplification without RT reaction; 8–10, mCRAMP amplification. (E and F) Frozen skin sections from day 1 newborn K14-Cath-PR-39 transgenic (E) and wild-type (F) mice fixed in 4% paraformaldehyde and processed for immunohistochemical stain by using a polyclonal antibody against PR-39. (×40.) (G) Western blot analysis of protein extracts from wounded wild-type mouse skin (lane 1), wounded K14-Cath-PR-39 transgenic mouse skin (lane 2), pig bone marrow as a control (lane 3), or GAS-infected K14-Cath-PR-39 mouse skin after immunoprecipitation with PR-39 antibody (lane 4). The blot was probed with a polyclonal antibody against PR-39. (H) Quantitative real-time PCR for mCRAMP expression in K14-Cath-mCRAMP mouse skin, compared with their littermate controls. Data are means (±SD) of four mice from each group.
K14-Cath-PR-39 transgenic mice are resistant to GAS infection. The area of necrotic ulcers in wild-type (WT) or transgenic mice was measured on day 4 after s.c. inoculation with GAS. (A) No difference in lesion size was seen between K14-Cath-mCRAMP transgenic and WT mice (data are means ± SD, representative of three independent experiments, n = 18 for WT and 14 for K14-Cath-mCRAMP transgenic mice). (B) K14-Cath-PR-39 transgenic mice had statistically smaller necrotic lesions, compared with WT mice (data are means ± SD, representative of three independent experiments, n = 8 for WT and 10 for K14-Cath-PR-39 transgenic mice). (C and D) WT (C) and K14-Cath-PR-39 transgenic mice (D) are shown on day 4 after s.c. inoculation with GAS. Representative images show the development of smaller lesions in K14-Cath-PR-39 transgenic mice. (E and F) Formalin-fixed, paraffin-embedded sections of infectious lesions from WT (E) and K14-Cath-PR-39 transgenic mice (F) show no appreciable difference in degree of leukocytic infiltrate in the center of the ulcer (hematoxylin/eosin-stained). (×100.) (G) CFU per lesion grown from GAS infectious lesions in WT and K14-Cath-PR-39 transgenic mice on day 4 after GAS inoculation. Lesions from K14-Cath-PR-39 transgenic mice had significantly fewer CFU, compared with lesions from WT mice (data are means ± SD and are representative of four separate experiments; n = 12 for WT and 12 for K14-Cath-PR-39 transgenic mice).
1T32 CA 81211/CA/NCI NIH HHS/United States
T32 CA081211/CA/NCI NIH HHS/United States
AI 052453/AI/NIAID NIH HHS/United States
AR 45676/AR/NIAMS NIH HHS/United States
R01 AR045676/AR/NIAMS NIH HHS/United States

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restaurants - Derry Forum - TripAdvisor
restaurants - Derry Forum
Browse all 327 Derry topics » restaurants
County Londonderry forums Derry forum Derry forums Derry forums All forums bazzaman1
restaurants Oct 13, 2010, 6:53 PM
any recommendations?? good chineese and italian.
See all 13 hotels in Derry 1-3 of 3 replies
Re: restaurants Oct 14, 2010, 4:31 AM
There are 2 good Chinese restaurants in the city:
Mandarin Palace, Queens Quay (City Centre)
Water Fortune, Spencer Road (Waterside)
There is one established authentic Italian restaurant:
La Sosta Ristorante, 45a Carlisle Road (City Centre) Tel: 71374817
but if you want a more informal and cheaper option for pastas or pizza:
Danano's, Lower Clarendon Street
Re: restaurants Oct 16, 2010, 5:29 PM
cheers.thanks for your help.
Re: restaurants Apr 15, 2011, 12:16 AM
-:- Message from TripAdvisor staff -:-This topic has been closed to new posts due to inactivity. We hope you'll join the conversation by posting to an open topic or starting a new one.To review the TripAdvisor Forums Posting Guidelines, please follow this link: http://www.tripadvisor.com/pages/forums_posting_guidelines.htmlWe remove posts that do not follow our posting guidelines, and we reserve the right to remove any post for any reason.Removed on: 12:16 am, April 15, 2011

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P. 1Investing in Energy, Water and FoodInvesting in Energy, Water and FoodRatings: 5.0 (1)|Views: 93|Likes: 0Published by Anric BlattAs the world progresses from 7 Billion to 9 Billion inhabitants, resource scarcity will become ever more pertinent, especially when amplified through climate change, disruptive weather anomalies and reserve bank printing presses As the world progresses from 7 Billion to 9 Billion inhabitants, resource scarcity will become ever more pertinent, especially when amplified through climate change, disruptive weather anomalies and reserve bank printing presses More info:Categories:Types, ResearchPublished by: Anric Blatt on Jan 29, 2013Copyright:Attribution Non-commercialAvailability:Read on Scribd mobile: iPhone, iPad and Android.download as PDF, TXT or read online from ScribdFlag for inappropriate content|Add to collectionSee moreSee lesshttps://www.scribd.com/doc/122836930/Investing-in-Energy-Water-and-Food01/29/2013pdftextoriginal 2012
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Activity (3)FiltersAdd to collectionReview Add NoteLikeShowingAllMost RecentReviewsAll NotesLikesYou've already reviewed this. Edit your review.Rating 0/5Post notePost reviewPost replyPost note and like1 hundred readsReplyAnric C Blatt added this noteStill our most popular downloadAnric C Blatt liked thisLoad more
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OPERATIONS IN THE WEST.; GEN. POPE'S POSITION Correspondence of the Cincinnati Commercial. ARMY OF THE MISSISSIPPI IN THE FIELD, NEAR NEW-MADRID, MO. - The New York Times
Archives|OPERATIONS IN THE WEST.; GEN. POPE'S POSITION Correspondence of the Cincinnati Commercial. ARMY OF THE MISSISSIPPI IN THE FIELD, NEAR NEW-MADRID, MO.
https://nyti.ms/1RIUyed
OPERATIONS IN THE WEST.; GEN. POPE'S POSITION Correspondence of the Cincinnati Commercial. ARMY OF THE MISSISSIPPI IN THE FIELD, NEAR NEW-MADRID, MO.
Tuesday, March 4, 1862.
Marching orders were issued on Thursday night, and on Friday morning, Feb. 28, the division was on its way for New-Madrid. The roads were in fine order for the infantry, and there was no great difficulty in moving the baggage train. We encamped the first night some twelve miles from Commerce. The second had the interesting feature of a skirmish of our cavalry and some rebel cavalry, near Sykeston, in which we took four prisoners and three small rifled cannon, one of our men being slightly wounded. We encamped at night at Sykeston, on the Bird's Point and Fulton (Ark.) Railroad. About 2 o'clock on Sunday morning we had a terrific storm of thunder, lightning and rain, and gained a rough experience of camp life. The camp was flooded, but the men continued in good spirits, especially as there was expectation of a fight before night. The roads were bad and the day cold, such weather as March usually brings to us in Ohio. At night we camped in order of battle not more than nine miles from New-Madrid. The night was cold, ice forming near an inch thick. We were moving early in the morning, the men eager to see the enemy, and growing more impatient at every step.
At 1 o'clock P.M. we had approached within about two and a half miles of the town, and the tops of the houses, and the smoke and steam from the steam and gunboats were plainly visible. At this point SANDS' Battery and the Twenty-seventh Ohio were sent forward, the infantry in and on either side of the road as skirmishers. Having advanced about one mile, the line of battle was formed, the Seventh Illinois Cavalry, and some companies of the Second Michigan Cavalry, on the right and left flanks. The Forty-third Ohio was on the left, west of the road, the Thirty-ninth Ohio on the right of the road, across a lane cut by the enemy to defend themselves in case of an attack on their fort. Immediately in the rear of the Thirty-ninth were the Sixty-third Ohio on the extreme right: the Twenty-sixth Illinois and the Eleventh Missouri was on the left, in the rear of the Forty-third Ohio.
The report was that there were five gunboats at the river wharf, and about five thousand troops in and about the fort, just beyond the southern part of the town. There had been some earthworks thrown up on the road by which we approached the town, but they were not defended. We learned also that Columbus was evacuated and that the force had moved to an island about ten miles above the town, which was strongly fortified, and accounted for the presence of the gunboats at New Madrid.
As the line of battle was being formed, a gunboat, from the upper part of the town threw a shell, which burst at a short range in mid-air. They fired at intervals, but the range was short. Soon, however, they began to play more accurately on the right wing, and the cannonading was as brisk as we could desire. The shot and shell fell in and around the Thirty-ninth and Sixty-third in a style that few of us had ever seen before, and the courage of the raen was fully tested. They stood firm, and gave indications of as much unconcern as if they were veterans.
We occupied our position near two hours, during which the infantry and cavalry did not fire a shot, and only a few guns of our artillery were heard. It was reported that one of our artillery shots smashed the wheel-house of a gunboat.
At about 4 o'clock, Gen. POPE gave orders for the force to fall back three-quarters of a mile and prepare for the night.
The order was obeyed without any confusion, and the men rested well in their tents, and talked over the wonders of the day.
The casualties of the day were as follows:
Killed -- LOUIS NINE, Company B, Thirty-ninth Ohio; a shell struck him in the lower part of the bowels, killing him instantly.
Wounded -- WM. VAN HORN, Company G, Thirty-ninth Ohio; a piece of shell struck him on the shoulder, the wound is not serious.
One of the Michigan Cavalry, Company I, whose name I have not heard, is reported to have his arm torn off. I hear, also, that an artillerist was wounded in the leg slightly.
L. BESSE, Seventh Illinois Cavalry, Company M, was shot in the foot by a comrade in dismounting.
To-day we remained in position of last night till 2 o'clock P.M., when the whole force fell back in line of battle, and are now encamped principally in cornfields north of the town.
A version of this archives appears in print on March 15, 1862, on Page 7 of the New York edition with the headline: OPERATIONS IN THE WEST.; GEN. POPE'S POSITION Correspondence of the Cincinnati Commercial. ARMY OF THE MISSISSIPPI IN THE FIELD, NEAR NEW-MADRID, MO. Order Reprints| Today's Paper|Subscribe

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Master Networks-Informational Meeting, Ossining/Briarcliff Thurs AM Tickets, Thu, Dec 21, 2017 at 8:00 AM | Eventbrite
Thu, December 21, 2017, 8:00 AM – 9:00 AM EST

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text:
I DO BBQ Invitation Backyard bbq Wedding Custom Personalized | Etsy
I DO BBQ Invitation, Backyard bbq Wedding, Custom Personalized Wedding Invitation Printable, Wedding Rehearsal, Save the Date, Tailgate
► Fits in a standard A7 Envelope.
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>> Date & Time
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► 5x7" PDF file
► PDF will not be editable files
► Print-lab quality designs
► Print at home or get it printed professionally (Walmart, Snapfish, Staples, etc.)
► If you would like us to print for you, please purchase a printing package in ADDITION to this invitation listing.
► Invitations run from $2.50+ per invitation card.
► You will receive a proof of your design within 1-3 business days. The proof will be sent to your Etsy inbox for your review and approval. Please make sure all spellings, punctuation and wording is correct. You can then either approve or request revisions to the design. I will make up to TWO revisions. The 3rd revision will be an extra $5.
► You will receive digital items only - no printed products will be shipped or mail.
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► Front Porch Press does not claim any ownership over the characters/graphics used in the designs. They belong to their respective copyright and trademark holders.
Do you need this for a different occasion other than what is listed? Please use the link found at the top of this listing to request your custom order.
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Project ID: #14688398
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Mom's & Baby Wear - Los Angeles, CA | Groupon
548 South Broadway, Los Angeles, CA 90013 548 South Broadway, Los Angeles Directions
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548 South Broadway,
Mom's and Baby Wear has all the necessary winter accessories for those cold months. Revamp your style. This store is ready to fill any woman's closet to the max. A clothing item at Mom's and Baby Wear will feel custom made for your body. It isn't easy to always look your best, and it's even harder when you're expecting a little bundle of joy. Try on some adorable pieces from Mom's and Baby Wear and make it that much easier to look that much better.
At Mom's and Baby Wear, you can find ample parking that is readily available any time of day.
Greater Griffith Park (4.9 mi)
Groupon has verified that the customer actually visited Mom's & Baby Wear.

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MLB V-Neck Raglan Glitter Team Player Jersey T-Shirt Youth Girls Size (4-17) | eBay
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Patent US4488647 - Flexible package with easy opening peel seal - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA package made of a flexible laminate has a heat-fusible seal of a strength sufficient to retain vacuum within the package and to withstand handling, but capable of being broken by hand manipulation....http://www.google.com/patents/US4488647?utm_source=gb-gplus-sharePatent US4488647 - Flexible package with easy opening peel sealAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS4488647 APublication typeGrantApplication numberUS 06/514,575Publication dateDec 18, 1984Filing dateJul 18, 1983Priority dateJul 18, 1983Fee statusPaidAlso published asCA1225376A, CA1225376A1, DE132369T1, DE3479883D1, EP0132369A2, EP0132369A3, EP0132369B1Publication number06514575, 514575, US 4488647 A, US 4488647A, US-A-4488647, US4488647 A, US4488647AInventorsJohn S. DavisOriginal AssigneeParamount Packaging CorporationExport CitationBiBTeX, EndNote, RefManPatent Citations (16), Referenced by (63), Classifications (21), Legal Events (7) External Links: USPTO, USPTO Assignment, EspacenetFlexible package with easy opening peel seal
US 4488647 AAbstract
______________________________________40 psi/.6 sec.       SEAL STRENGTH G/IN______________________________________200� F.       475210� F.       525220� F.       650230� F.       700240� F.       800250� F.       900260� F.       920270� F.       920280� F.       920290� F.       920300� F.       920400� F.       900450� F.       900______________________________________
As will be seen from the above, as the temperature approached 250� F., the seal strength reached a fairly constant level of approximately 900 grams per inch, which held throughout the range of approximately 250� F. throught 450� F. In this regard, it will be observed in FIGS. 5 and 6 of the drawings that sealing takes place in the areas of the seam 62 and gussets 64a and 64b across four thicknesses of the package material (i.e. laminate 10 or 18), and in other areas of the mouth 64 across two thicknesses.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3192091 *Aug 1, 1960Jun 29, 1965Lever Brothers LtdMethod of sealing a containerUS3278109 *Jun 10, 1964Oct 11, 1966E S & A Robinson Holdings LtdBag, carton and packageUS3491935 *Aug 8, 1966Jan 27, 1970Phillips Petroleum CoMethod of forming a peelable sealUS3533548 *Oct 17, 1968Oct 13, 1970Bard Inc C RMethod of ascertaining validity of heat seal and product of said methodUS3551436 *Nov 10, 1969Dec 29, 1970American Cyanamid CoCertain 4-(thiazolyl) and 4-(oxazolyl) pyridinium saltsUS3551746 *Jan 2, 1968Dec 29, 1970Westinghouse Electric CorpVoltage acceptor circuit and overvoltage undervoltage detector for use thereinUS3552638 *Aug 14, 1968Jan 5, 1971Nat Distillers Chem CorpPeel-open thermoplastic package for sterilized articlesUS3595468 *Jun 6, 1969Jul 27, 1971Dow Chemical CoOpening deviceUS4097236 *Jan 24, 1977Jun 27, 1978Faser IndustriesMethod of detecting heat seal breaks and package thereofUS4183434 *Sep 2, 1977Jan 15, 1980Pharmachem CorporationPeelable sealUS4197947 *Apr 19, 1979Apr 15, 1980Paper Manufacturers CompanySterile packageUS4252846 *Sep 22, 1975Feb 24, 1981The Dow Chemical CompanyPackages embodying a controlled peel seal and method of preparing sameUS4264392 *Nov 29, 1978Apr 28, 1981Pharmachem CorporationProcess for forming a peelable sealUS4279344 *Dec 26, 1979Jul 21, 1981Reynolds Metals CompanyHeat-sealable and peelable laminated packaging constructionUS4361237 *Jun 17, 1981Nov 30, 1982Ucb Societe AnonymeHeat sealable packaging film producing a peelable sealUS4365716 *Oct 20, 1980Dec 28, 1982Pharmachem CorporationPeelable seal* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS4702376 *Oct 3, 1986Oct 27, 1987Fairprene Industrial Products Company, Inc.Composite vacuum bag material having breather surfaceUS4709818 *Aug 20, 1985Dec 1, 1987East/West Industries, Inc.Apparatus and method for compression packaging a compressible article into a container and a container thereforUS4712727 *Apr 10, 1987Dec 15, 1987Minnesota Mining And Manufacturing CompanyGable-top container closure systemUS4756426 *Apr 10, 1987Jul 12, 1988Minnesota Mining And Manufacturing CompanyGable-top containerUS4792048 *Dec 14, 1987Dec 20, 1988Minnesota Mining And Manufacturing CompanyGable-top containerUS4813547 *Dec 14, 1987Mar 21, 1989Minnesota Mining And Manufacturing CompanyGable-top container closure systemUS4813548 *Dec 14, 1987Mar 21, 1989Minnesota Mining And Manufacturing CompanyGable-top containerUS4869372 *Mar 9, 1988Sep 26, 1989Minnesota Mining And Manufacturing CompanyGable-top containerUS4869373 *Mar 9, 1988Sep 26, 1989Minnesota Mining And Manufacturing CompanyGable-top container closure systemUS4872562 *Mar 9, 1988Oct 10, 1989Minnesota Mining And Manufacturing CompanyGable-top containerUS4884695 *Dec 20, 1988Dec 5, 1989Roby Teknik AktiebolagPacking containerUS4903891 *Jul 7, 1989Feb 27, 1990International Paper CompanyGable top carton sealing constructionUS4949529 *Sep 7, 1988Aug 21, 1990Paramount Packaging CorporationVacuum package with smooth surface and method of making sameUS5352466 *Oct 15, 1991Oct 4, 1994Kraft General Foods, Inc.Tabbed easy-open brick coffee packageUS5407278 *Dec 10, 1993Apr 18, 1995Fres-Co System Usa, Inc.Dual compartment easily openable flexible packageUS5531325 *Mar 5, 1993Jul 2, 1996The Procter & Gamble CompanyStoring and dispensing system for products packed in a sealed pouchUS5655707 *May 30, 1996Aug 12, 1997International PaperPaperboard carton with cohesive closureUS5660479 *Feb 16, 1996Aug 26, 1997Reynolds Consumer Products Inc.Easy open package headerUS6076969 *Dec 1, 1998Jun 20, 2000Sonoco Development, Inc.Resealable closure and method of making sameUS6210038 *Nov 3, 1998Apr 3, 2001Reynolds Consumer Products, Inc.Closure arrangement having a peelable seal indicatorUS6213645 *Mar 14, 2000Apr 10, 2001Fres-Co System Usa, Inc.Flexible package with sealed edges and easy to open mouthUS6287612Nov 23, 1999Sep 11, 2001Nestec S.A.Liquid food products and package thereforeUS6539691Mar 14, 2001Apr 1, 2003Fres-Co System Usa, Inc.Flexible package with sealed edges and easy to open mouthUS7302783 *Dec 19, 2006Dec 4, 2007The Procter & Gamble CompanyMethod for filling a package for compressible flat articlesUS7871696Nov 21, 2006Jan 18, 2011Kraft Foods Global Brands LlcPeelable composite thermoplastic sealants in packaging filmsUS7871697Jan 18, 2011Kraft Foods Global Brands LlcPeelable composite thermoplastic sealants in packaging filmsUS7963413May 23, 2006Jun 21, 2011Kraft Foods Global Brands LlcTamper evident resealable closureUS8110286Dec 28, 2010Feb 7, 2012Kraft Foods Global Brands LlcPeelable composite thermoplastic sealants in packaging filmsUS8114451Dec 27, 2006Feb 14, 2012Kraft Foods Global Brands LlcResealable closure with package integrity featureUS8308363Nov 13, 2012Kraft Foods Global Brands LlcPackage integrity indicator for container closureUS8389596Feb 25, 2011Mar 5, 2013Kraft Foods Global Brands LlcLow-tack, UV-cured pressure sensitive adhesive suitable for reclosable packagesUS8398306Mar 19, 2013Kraft Foods Global Brands LlcFlexible package with internal, resealable closure featureUS8408792Apr 2, 2013Kraft Foods Global Brands LlcPackage integrity indicating closureUS8470397Jan 25, 2012Jun 25, 2013Kraft Foods Global Brands LlcPeelable composite thermoplastic sealants in packaging filmsUS8722122Nov 5, 2012May 13, 2014Intercontinental Great Brands LlcPackage integrity indicator for container closureUS8746483May 16, 2011Jun 10, 2014Intercontinental Great Brands LlcTamper evident resealable closureUS8763890Feb 25, 2011Jul 1, 2014Intercontinental Great Brands LlcPackage having an adhesive-based reclosable fastener and methods thereforUS8889205Jan 11, 2012Nov 18, 2014Intercontinental Great Brands LlcResealable closure with package integrity featureUS8951591Apr 3, 2014Feb 10, 2015Intercontinental Great Brands LlcPackage integrity indicator for container closureUS9096780Feb 25, 2011Aug 4, 2015Intercontinental Great Brands LlcReclosable fasteners, packages having reclosable fasteners, and methods for creating reclosable fastenersUS9150342Aug 1, 2005Oct 6, 2015Intercontinental Great Brands LlcResealable tray containerUS9187228Nov 6, 2012Nov 17, 2015Intercontinental Great Brands LlcPackage integrity indicating closureUS9205967Jan 26, 2011Dec 8, 2015Generale BiscuitResealable packaging for food products and method of manufacturingUS9221590Mar 21, 2011Dec 29, 2015Generale BiscuitResealable packaging for food products and method of manufacturingUS9309027Jun 7, 2013Apr 12, 2016Intercontinental Great Brands LlcPeelable composite thermoplastic sealants in packaging filmsUS9382461Mar 1, 2013Jul 5, 2016Intercontinental Great Brands LlcLow-tack, UV-cured pressure sensitive adhesive suitable for reclosable packagesUS20060257055 *Apr 27, 2006Nov 16, 2006Dirk OberdorfPackaging for free-flowing products, consisting of a heat-sealed bagUS20070087088 *Sep 28, 2006Apr 19, 2007Joachim BellmanMethod of packaging a product, a package, particularly containing coffee, and a packaging machineUS20070095019 *Dec 19, 2006May 3, 2007Filiz CotertPackage for compressible flat articlesUS20070104395 *Nov 7, 2005May 10, 2007Kraft Foods Holdings, Inc.Flexible package with internal, resealable closure featureUS20070231516 *Apr 4, 2006Oct 4, 2007Versluys Robert TLaminate material for vacuum-packed packagesUS20080118688 *Nov 21, 2006May 22, 2008Kraft Foods Holdings, Inc.Peelable composite thermoplastic sealants in packaging filmsUS20080131636 *Feb 14, 2008Jun 5, 2008Kraft Foods Holdings, Inc.Peelable composite thermoplastic sealants in packaging filmsUS20110143133 *Jun 16, 2011Panagiotis KinigakisPolymeric Base Having an Adhered Low-Tack Adhesive ThereonUS20110155623 *Dec 28, 2010Jun 30, 2011Kraft Foods Holdings, Inc.Peelable composite thermoplastic sealants in packaging filmsUS20110210163 *Sep 1, 2011Kerri Kim ClarkPackage Having An Adhesive-Based Reclosable Fastener And Methods ThereforUS20110211773 *Sep 1, 2011Romeo Derek JReclosable Package Using Low Tack AdhesiveUS20110211778 *Sep 1, 2011Paul Anthony ZerfasReclosable Fasteners, Packages Having Reclosable Fasteners, and Methods for Creating Reclosable FastenersUS20110213092 *Sep 1, 2011Jeffrey James BoyceLow-Tack, UV-Cured Pressure Sensitive Adhesive Suitable for Reclosable PackagesEP0361711A2 *Sep 7, 1989Apr 4, 1990Paramount Packaging CorporationVacuum package with smooth surface and method of making sameEP0657367A2 *Dec 8, 1994Jun 14, 1995Fres-Co System Usa, Inc.Dual compartment easily openable flexible packageEP1772380A1 *Sep 28, 2005Apr 11, 2007Kraft Foods R & D, Inc.A method of packaging a product, a package, particularly containing coffee, and a packaging machineWO1993017933A1 *Mar 5, 1993Sep 16, 1993The Procter & Gamble CompanyStoring and dispensing system for products packed in a sealed pouch* Cited by examinerClassifications U.S. Classification206/525, 426/413, 206/459.5, 426/404, 229/137, 383/89, 206/524.8, 426/123, 383/210International ClassificationB65D5/74, C09J123/08, B31B1/90, B65D5/40, B32B27/08, B65D77/30, B65D5/43, B65D77/12Cooperative ClassificationB32B27/08, B65D77/12European ClassificationB32B27/08, B65D77/12Legal EventsDateCodeEventDescriptionJul 18, 1983ASAssignmentOwner name: PARAMOUNT PACKAGING CORPRATION, OAK AVE., CHALFONTFree format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:DAVIS, JOHN S.;REEL/FRAME:004154/0223Effective date: 19830714Apr 16, 1985CCCertificate of correctionMay 13, 1988FPAYFee paymentYear of fee payment: 4Jun 17, 1992FPAYFee paymentYear of fee payment: 8Jul 23, 1996REMIMaintenance fee reminder mailedAug 12, 1996SULPSurcharge for late paymentAug 12, 1996FPAYFee paymentYear of fee payment: 12RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services


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Braxton Miller, David Cobb, Anthony Hitchens Big Ten helmet stickers - College Football Nation Blog - ESPN
Big Ten helmet stickers: Week 9673dBrian Bennett and Adam RittenbergMarvin Gentry/USA TODAY SportsTime for the SEC to put bowls, bad offseason in the rearview mirror10mAlex ScarboroughJeff Hanisch/USA TODAY SportsThe week ahead in the Big Ten16mDan MurphyPaul Bergstrom/Icon Sportswire3-point stance: Coaching parade continues at Illinois9hIvan MaiselTom Hauck for Student SportsEarly Offer: Is Virginia Tech the team to beat with Landon Dickerson?48mJeremy CrabtreeAP Photo/Nick WassMaryland names Perry Hills starting QB3dJosh MoyerIs Bob Stoops on the hot seat in 2015?3dESPN.com staffWhat you need to know about Illinois interim coach Bill Cubit3dMitch ShermanFiring of Illinois coach Tim Beckman long overdue3dJosh MoyerTom Pennington/Getty ImagesMinnesota releases its own 'Frogger' game3dBrian BennettJim McElwain's quarterback teaching put to the test3dEdward AschoffStephan Savoia/APBC's Connor Wujciak: 'We want to have a top 5 defense'3dAndrea AdelsonAP Photo/Brynn AndersonNick Saban not in a rush to name Alabama's starting QB3dAlex ScarboroughGreg Ostendorf/ESPNAuburn newcomers fit right in with their bleached blonde hair3dGreg OstendorfBaylor's offense won't miss a beat with QB Seth Russell3dESPN.com staffScout's Take: Ahmir Mitchell to Michigan3dTom LuginbillBig Ten helmet stickers: Week 910/27/20130 SharesEmailCommentBrian BennettCloseBrian BennettESPN Staff Writer ESPN.com Big Ten reporter.
Graduate of Northwestern University.Follow on Twitter0 SharesEmailPrintCommentRecognizing the best and brightest from the Big Ten in Week 9:Ohio State QB Braxton Miller and RB Carlos Hyde: The Big Ten's most dangerous offensive backfield put up huge numbers once again, as Ohio State crushed Penn State at The Shoe. Miller, looking more like the Heisman Trophy candidate many thought he would be before the season, completed 18 of 24 passes for 252 yards and three touchdowns and added 68 rush yards and two touchdowns. Hyde continued his surge with 147 rush yards and two touchdowns on only 16 carries.Minnesota RB David Cobb: The Gophers pounded away for 271 rushing yards in a 34-23 win over Nebraska, and Cobb led the way. Taking over as the starting running back, Cobb carried the ball 31 times for 138 yards.Iowa LBs Anthony Hitchens and James Morris: Hitchens had nine tackles and a sack and forced a fumble as Northwestern was driving into Hawkeyes territory. Morris had eight tackles and two sacks and recovered that fumble. Both guys were key in helping Iowa limit Northwestern to just one touchdown in a 17-10 overtime win.Michigan State RB Jeremy Langford and QB Connor Cook: Langford has quickly established himself as the Spartans' top offensive weapon, and he showed why again on Saturday by running 22 times for 104 yards and two scores in a 42-3 victory at Illinois. Cook had a fumble at the goal line early and should have been picked off on his touchdown throw near the end of the first half. But he threw just one incompletion in 16 attempts, finishing with 208 yards and three scores. Michigan State went 14-for-16 on third down and had possibly its most balanced offensive attack in the past two seasons.

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Alice Harnoncourt - Wikipedia, the free encyclopedia
Alice Harnoncourt (née Hoffelner; born 26 September 1930) is an Austrian classical violinist. She is noted for her playing of the Baroque violin, viol, and other stringed instruments. In 1953 she and her husband Nikolaus Harnoncourt founded the Concentus Musicus Wien, initiating the movement to perform early music on period instruments.
Alice Hoffelner was born in 1930 in Vienna, Austria. She studied violin and other stringed instruments as a student of Josef Mertin and became interested in Baroque violin.
In 1953, along with her husband Nikolaus Harnoncourt, she founded the period instrument ensemble Concentus Musicus Wien. She served as its principal violinist until 1985. Their ensemble strongly influenced and changed the performance and recording of early music by contemporary musicians, as it emphasized the use of period instruments.
Until 1968, Harnoncourt performed on a Jakob Stainer violin made in 1658. She switched to an instrument of 1665 vintage, also by a maker from the Absam region of Austria. In addition to baroque violin, she has performed on the pardessus de viole (the smallest form of the viola da gamba), viola and viola d'amore.

value: This website is the English-language edition of the free online encyclopedia Wikipedia. It was founded on 15 January 2001 as Wikipedia's first edition and, as of October 2021, has the most articles of any edition, at 6,412,521.


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Book Sandos Cancun Luxury Resort All Inclusive, Cancun, Mexico - Hotels.comEnglish (United States)Book online or call 800-246-8357This call is free. 24 hours a day; 7 days a week.HotelsHotel DealsPackages & FlightsGroupsGift CardsHelpWebsite feedbackSign in & AccountSign inCreate an accountYour bookingsReview a hotelHotels.com® RewardsYour bookingsJump toOverviewRoom choicesMapReviewsHotel informationLowest price: $237Book NowHotelsMexico HotelsCancun HotelsSandos Cancun Luxury Resort All InclusiveAll hotels in Cancun, Quintana Roo, Mexico1 room, 2 adultsDestination, hotel, landmark or addressCheck inCheck out Rooms123456789+Room 1:Adults12345678Aged 18+Children01230-17Age at check in:Child 1:-?-<11234567891011121314151617SearchYou can collect Hotels.com® Rewards nights hereSandos Cancun Luxury Resort All Inclusive, Cancun4 starsKm 14 Mz 53 Lote 37-1 ZH, Cancun, QROO, 77500, Mexico, 800-491-6126Lowest price$349$237Price GuaranteePrice Guarantee on hotel bookings. If you find a better price on exactly the same stay, we’ll either match it or give you a coupon. Click below for details.Jump to:OverviewRoom choicesMapReviewsHotel informationLobbyLobbySuite Sandos Ocean or Lagoon Partial View with Balcony - GuestroomSuite Sandos Ocean or Lagoon Partial View with Balcony - GuestroomDeluxe Room Ocean or Lagoon Partial View with Balcony - GuestroomDeluxe Room Ocean or Lagoon Partial View with Balcony - GuestroomSuperior Room Ocean or Lagoon Partial View - GuestroomSuperior Room Ocean or Lagoon Partial View - GuestroomDeluxe Room Ocean or Lagoon Partial View with Balcony - GuestroomSuperior Room Ocean or Lagoon Partial View - GuestroomSuite Sandos Ocean or Lagoon Partial View with Balcony - GuestroomDeluxe Room Ocean or Lagoon Partial View with Balcony - GuestroomLaguna suite - GuestroomLaguna suite - GuestroomCaribe suite - GuestroomCaribe suite - GuestroomCaribe suite - GuestroomCaribe suite - GuestroomCaribe suite - GuestroomCaribe suite - GuestroomCaribe suite - GuestroomLaguna suite - GuestroomCaribe suite - GuestroomSuite Sandos Ocean or Lagoon Partial View with Balcony - In-Room DiningSuite Sandos Ocean or Lagoon Partial View with Balcony - Living AreaDeluxe Room Ocean or Lagoon Partial View with Balcony - BalconyDeluxe Room Ocean or Lagoon Partial View with Balcony - BathroomSuite Sandos Ocean or Lagoon Partial View with Balcony - BathroomCaribe suite - BathroomPoolPoolPoolPoolPoolPoolPoolOutdoor PoolOutdoor PoolFitness FacilityGymGymGymGymGymSpaSpa ReceptionMassageSpa TreatmentSpa TreatmentProperty AmenityDiningRestaurantRestaurantRestaurantHotel BarHotel BarHotel BarHotel LoungeHotel LoungeHotel InteriorHotel InteriorMeeting FacilityBeachBeachBeachBeachBeachTerrace/PatioSundeckExteriorExteriorAerial ViewHotel & grounds Stein Erik, NO, Jul 2016[1/74]Flag this imageSee if the hotel has anything planned that may affect your stayThe property will be renovating from 21 October 2016 to 23 December 2016 (completion date subject to change). The following areas are affected: Bar/lounge
Renovation work will only be conducted during business hours. Every effort will be made to minimize noise and disturbance. All-inclusive beachfront resort with spa, near La Isla Shopping Mall Free WiFi and free parking Main amenities213 guestroomsOn the beach5 restaurants and 2 bars/loungesFull-service spa3 outdoor poolsRooftop terrace2 outdoor tennis courtsFree beach cabanasConference centerIn-room childcare24-hour front deskAir conditioningWhat’s aroundIn Avenida KukulkanLa Isla Shopping Mall (1.4 mi / 2.3 km)Delfines Beach (2.3 mi / 3.7 km)El Rey Ruins (2.4 mi / 3.9 km)Ballenas Beach (0.2 mi / 0.4 km)Aquaworld (0.7 mi / 1.1 km)See mapExcellent4.2 / 5WellnessGreat wellness & sports facilitiesServiceFantastic serviceFoodDelicious foodWiFiWiFi system needs upgrading621See all 621 Hotels.com reviewsTripAdvisor Traveller Rating: 4.5From 3,733 reviewsTripAdvisor Traveller RatingEmailSaveShareHotels.com® RewardsBook this hotel and collect nights after your staySandos Cancun Luxury Resort All Inclusive, CancunHotel Info: 866-539-8117 from $237Destination, hotel, landmark or addressCheck inCheck out Rooms123456789+Room 1:Adults12345678Aged 18+Children01230-17Age at check in:Child 1:-?-<11234567891011121314151617Check availability Caribe suiteLaguna suitePanoramic Suite, Balcony, Lagoon ViewSuperior Room Ocean or Lagoon Partial ViewSuite Sandos Ocean or Lagoon Partial View with Balcony Deluxe Room Ocean or Lagoon Partial View with BalconyCheck availability More great choicesSee all hotels in CancunList viewMap viewSee all hotels in CancunAt a glanceKey factsHotel sizeThis hotel has 213 roomsThis hotel is arranged over 8 floorsArriving/leavingCheck-in time starts at 3 PMCheck-out time is noonRequired at check inCredit card or cash deposit required
Free WiFi in roomsTransportationParkingFree valet parkingSee mapOther informationAll-inclusive (taxes and gratuities included) Resort fee includedAlso known asCancun All Inclusive LuxurySandos Luxury Experience Resort All InclusiveSandos Cancun Luxury Resort All InclusiveSandos Luxury Resort All InclusiveSandos LuxuryCancun Luxury Experience ResortExperience ResortExperience Resort CancunLuxury Cancun ResortSandos Cancun Luxury ExperienceSandos Cancun Luxury Experience Resort All InclusiveSandos Luxury CancunSandos Luxury ExperiencePoliciesThe property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation. Only registered guests are allowed in the guestrooms. Guests under 18 years old are not allowed in the fitness facility. Children under 18 years old are not allowed in the spa without adult supervision. Guests under 16 years old are not allowed in the spa. Parking height restrictions apply. Mandatory feesThe charges below are included in the total price displayed: Resort fee Optional extrasLate check-out can be arranged for an extra charge of MXN 900Babysitting/childcare is available for an extra chargeNearby Four Star Cancun hotelsMarriott CasaMagna Resort Cancun4 starsExcellent4.5 / 5From $209The Royal Sands & Spa All Inclusive4 starsExcellent4.4 / 5From $386$212Casa Turquesa4 starsExcellent4.1 / 5From $361$217Fiesta Americana Condesa Cancun All Inclusive4 starsExcellent4.3 / 5From $630$356See more Four Star Cancun hotelsIn the hotelTaking the kids?In-room childcare (surcharge)Food and drink5 restaurants 2 bars/lounges Coffee shop/café Poolside bar 24-hour room service Barbecue grills Things to doFree beach cabanasBeach sun loungersNumber of outdoor pools - 3Pool sun loungers24-hour fitness facilitiesOutdoor tennis courts - 2Full-service spaSpa treatment room(s)Beach umbrellasPool umbrellasSpa tubBeach towelsSteam roomSaunaWorking awayConference space size (feet) - 6254Conference space size (meters) - 581One meeting roomConference centerServices24-hour front deskConcierge servicesTours/ticket assistanceDry cleaning/laundry serviceLaundry facilitiesHair salonLuggage storageWedding servicesMultilingual staffPorter/bellhopFacilitiesNumber of buildings/towers - 1Year Built 1998Elevator/liftATM/bankingDesignated smoking areasRooftop terracePicnic areaAccessibilityAccessible bathroomIn-room accessibilityRoll-in showerIn the roomHome comfortsIn-room climate control (air conditioning)Air conditioningCoffee/tea makerBathrobesSlippersIron/ironing boardSleep wellPillow menuBlackout drapes/curtainsTurndown servicePillowtop mattressThings to enjoyIn-room massage availableFreshen upPrivate bathroomSeparate bathtub and showerFree toiletriesHair dryerBe entertained32-inch flat-screen TV Cable TV channels IPod docking station Stay connectedDeskFree WiFiPhoneFood and drinkFree bottled waterMoreDaily housekeepingIn-room safe (laptop compatible)Connecting/adjoining rooms availableTop Cancun hotelsAzul Sensatori Mexico by Karisma - All Inclusive4.5 starsOutstanding5.0 / 5Hotel Isla Caracol2.5 starsOutstanding5.0 / 5Pa'Xa Mama Hotel Boutique3 starsOutstanding5.0 / 5From $36Posada Paso del Sol2.5 starsOutstanding5.0 / 5From $28Recently reviewed hotels in CancunGran Caribe Resort & Spa All Inclusive4 starsExcellent4.0 / 5From $419$189"Positive but entertainment is very primitive needs more Latin music Will be more fun then"Dec 8, 2016GR Solaris Cancun & Spa - All Inclusive4 starsExcellent4.0 / 5From $427$213"We had a very good stay during our vacation. Place is clean and close to the beach. There is a bus stop in front of the hotel, very easy to get around the area. Food is ok and…"Dec 7, 2016Hyatt Ziva Cancun All Inclusive4.5 starsOutstanding4.8 / 5From $665$333"Beautiful Hotel. Has an Adult only side. But mostly for Families. "Dec 6, 2016Grand Oasis Palm By Lifestyle - All Inclusive3.5 starsGood3.1 / 5From $560$258"The hotel room was very nice and the.staff is the best wide variety of activities however there was no wifi in the room you have to sit in the lobby or pay for the wifi."Dec 6, 2016Nearby hotelsStella Maris Three Bedroom Villa3 starsGood3.3 / 5From $210Golden Parnassus Resort & Spa -Adults Only- All Inclusive3.5 starsGood3.8 / 5From $424$204Oleo Cancun Playa All Inclusive4 starsNo guest ratings yetFrom $1,332Secrets The Vine Cancun All Inclusive5 starsOutstanding4.6 / 5From $528$317Also popular with travelers from the USASee all hotels in CancunList viewMap viewSee all hotels in CancunSpecial featuresAll inclusiveThis resort is all-inclusive. Onsite food and beverages are included in the room price (some restrictions may apply).
St. Trop - This beachfront restaurant specializes in Caribbean cuisine and serves lunch, dinner, and light fare. Guests can order drinks at the bar and enjoy alfresco dining (weather permitting). Gaijin Teppanyaki - This restaurant specializes in Asian cuisine and serves dinner only. Reservations are required. Seasons Restaurant - Overlooking the ocean and pool, this fine-dining restaurant specializes in international cuisine and serves dinner only. Bar One - This lobby lounge overlooks the pool. Sandos Cancun Luxury Resort All Inclusive, Cancun’s small printAlso known asCancun All Inclusive LuxurySandos Luxury Experience Resort All InclusiveSandos Cancun Luxury Resort All InclusiveSandos Luxury Resort All InclusiveSandos LuxuryCancun Luxury Experience ResortExperience ResortExperience Resort CancunLuxury Cancun ResortSandos Cancun Luxury ExperienceSandos Cancun Luxury Experience Resort All InclusiveSandos Luxury CancunSandos Luxury ExperiencePoliciesThe property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation. Only registered guests are allowed in the guestrooms. Guests under 18 years old are not allowed in the fitness facility. Children under 18 years old are not allowed in the spa without adult supervision. Guests under 16 years old are not allowed in the spa. Parking height restrictions apply. Mandatory feesThe charges below are included in the total price displayed: Resort fee Optional extrasLate check-out can be arranged for an extra charge of MXN 900Babysitting/childcare is available for an extra chargeWe have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.Recent reviewsExcellent 4.2 /5 from 621 reviewsSandos Cancun Luxury Resort All Inclusive, CancunExcellent4.0 / 5Strict dress code for men at restaurants.A little strict when it comes to men attire during dinner. We were turned down twice the same night. Once for wearing dress shorts instead of dress pants. No sports bar for watching sports, however sports channels were available in the room.Oct 13, 2016Genuine Hotels.com guest reviewA Traveler, us6 night romance tripSandos Cancun Luxury Resort All Inclusive, CancunExcellent4.0 / 5Good timeThe customer service was excellent!Everyone was extremely helpful and friendly.The room was decent.Drinks were tasty and strong.The beach is beautiful, as expected.The location was good. We took the public bus ($1.00 USD) to go shopping at the flea market and to the clubs.The ride was about 15-20 minutes.There were a few issues I must say.On the first night, I went to shower after my friend showered and the water stopped running. No water from the shower nor the sink. We called down to the front desk and after about 30 minutes the issue was corrected. No one notified us that it was working, I just kept turning it on and off every minute or so. It would have been nice if we were notified. 2) The food from the two restaurants, steakhouse and Italian,were not good at all. The buffet and the outdoor snack bar had the best food. That's where we ate most of our meals. I think they should have a Mexican restaurant in there. I would have liked to have made to order authentic Mexican food. 3) While at the steakhouse I did see a flying waterbug. The waiter also saw it and quickly handled it. Gross, but I guess I can understand. We just made sure to always keep our luggage zipped. 4)From inside the room, we were able to hear everything that was happening in the hallway. It was pretty quiet while we were there, but I can imagine that being annoying during their busy season. Overall, I enjoyed my time in Cancun and at this resort. The price was good and I would return.Aug 24, 2016Genuine Hotels.com guest reviewA Traveler, us4 night trip with friendsSandos Cancun Luxury Resort All Inclusive, CancunExcellent4.0 / 5Sandos overall is a pretty good resort.
b/c you can even hear it when you are out on the beach.Jun 10, 2016Genuine Hotels.com guest reviewHyo Jeong, us3 night romance tripSandos Cancun Luxury Resort All Inclusive, CancunOutstanding5.0 / 5Very Nice !Everything was great except the food ! Only the steak house was exceptional !Jun 2, 2016Genuine Hotels.com guest reviewA Traveler, us5 night romance tripSandos Cancun Luxury Resort All Inclusive, CancunExcellent4.0 / 5Good over all but the last day of the stay there was a lot of banging and noise from them trying to renovate parts of the hotel. It really disturbed the peace and quiet I was trying to haveMay 21, 2016Genuine Hotels.com guest reviewAnthony, us3 night tripSee all reviewsSandos Cancun Luxury Resort All Inclusive, CancunIs the description of this hotel not correct? Tell usChoose one of the following to unlock Secret Prices and pay less on select hotels.EmailSign up for our latest offersHotels.com appDownload the app and book on the goHotels.com® RewardsJoin now to collect 10 nights, get 1 free*Top DestinationsHotels in New York, New YorkHotels in Las Vegas, NevadaHotels in Chicago, IllinoisHotels in San Francisco, CaliforniaHotels in Washington, District of ColumbiaHotels in Boston, MassachusettsHotels in San Diego, CaliforniaHotels in Orlando, FloridaHotels in London, United KingdomHotels in New Orleans, LouisianaHotels in Los Angeles, CaliforniaHotels in San Antonio, TexasHotels in Paris, FranceHotels in Seattle, WashingtonHotels in Atlanta, GeorgiaHotels in Philadelphia, PennsylvaniaHotels in Austin, TexasHotels in Atlantic City, New JerseyHotels in Rome, ItalyHotels in Myrtle Beach, South CarolinaHotels in Dallas, TexasHotels in Houston, TexasHotels in Denver, ColoradoHotels in Miami, FloridaCustomer ServiceYour bookingsFAQsContact usWebsite feedbackReview a hotelFor Suppliers, Affiliates and the MediaAdd HotelAffiliate with usPrivate LabelPromote with UsTravel AgentsPress OfficeUser Terms and Privacy PolicyTerms & ConditionsPrivacy PolicyCookie PolicyAbout our adsAbout UsJobsTravel GuidesTop 50 CitiesAll countriesAll hotelsSite index© 2016 Hotels.com, L.P. All rights reserved.Hotels.com and the Hotels.com logo are trademarks or registered trademarks of Hotels.com, LP in the U.S. and/or other countries. All other trademarks are property of their respective owners.* Learn more about Hotels.com® RewardsABOUT SSL CERTIFICATES

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