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Patent US5330503 - Spiral suture needle for joining tissue - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsSuture devices, particularly useful in endoscopic surgery, include a suture device made of bioabsorbable material having an elongate body member with a sharp distal end for penetrating tissue and means for locking the suture device in tissue to prevent forward and rearward movement and a suture device...http://www.google.com/patents/US5330503?utm_source=gb-gplus-sharePatent US5330503 - Spiral suture needle for joining tissueAdvanced Patent SearchPublication numberUS5330503 APublication typeGrantApplication numberUS 07/928,567Publication dateJul 19, 1994Filing dateAug 13, 1992Priority dateMay 16, 1989Fee statusLapsedAlso published asUS5053047, WO1990014795A2, WO1990014795A3Publication number07928567, 928567, US 5330503 A, US 5330503A, US-A-5330503, US5330503 A, US5330503AInventorsInbae YoonOriginal AssigneeInbae YoonExport CitationBiBTeX, EndNote, RefManPatent Citations (30), Referenced by (222), Classifications (14), Legal Events (6) External Links: USPTO, USPTO Assignment, EspacenetSpiral suture needle for joining tissueUS 5330503 AAbstract Suture devices, particularly useful in endoscopic surgery, include a suture device made of bioabsorbable material having an elongate body member with a sharp distal end for penetrating tissue and means for locking the suture device in tissue to prevent forward and rearward movement and a suture device made of bioabsorbable material having a hinge-like joint for folding a distal portion at a precise location to be juxtaposed with a proximal portion for adjustable locking. Methods of using the suture devices for joining tissue sections, such as in tuboplasty, for closing anatomical lumens and for subcuticular suturing.
What is claimed: 1. A suture needle for joining tissue comprisingan elongate body member having a sharp distal end, a proximal end and a spiral configuration therebetween forming a plurality of coils whereby multiple bites of tissue can be penetrated with said suture needle, said spiral configuration being formed of coils having diameters increasing as they approach said sharp distal end. 2. A suture needle for joining tissue comprisingan elongate body member having a sharp distal end, a proximal end and a spiral configuration therebetween forming a plurality of coils whereby multiple bites of tissue can be penetrated with said suture needle, said spiral configuration being formed of coils having diameters decreasing as they approach said sharp distal end. 3. A suture needle for joining tissue comprisingan elongate body member having a sharp distal end, a proximal end and a spiral configuration therebetween forming a plurality of coils whereby multiple bites of tissue can be penetrated with said suture needle, said spiral configuration being formed of coils disposed in a single plane. Description
This is a divisional application of application Ser. No. 07/744,406, filed Aug. 13, 1991, now U.S. Pat. No. 5,222,976, which is a division of application Ser. No. 07/352,337 filed May 16, 1989, now U.S. Pat. No. 5,053,047.
There have been many attempts to provide devices to take the place of conventional suturing with a suture needle and a length of suture material; however, such prior art devices have essentially been staples, clips, clamps or other fasteners not providing the adjustable tension obtained by the surgeon while knotting a length of suture material. U.S. Pat. No. 3,827,277 to Weston, U.S. Pat. No. 4,060,089 to Noiles, U.S. Pat. No. 4,490,326 to Beroff et al, U.S. Pat. No. 4,513,746 to Aranyi et al, U.S. Pat. No. 4,532,926 to O'Holla, U.S. Pat. No. 4,548,202 to Duncan, No. 4,573,469 to Golden, U.S. No. 4,590,937 to Deniega, U.S. Pat. No. 4,595,007 to Meride, U.S. Pat. No. 4,602,634 to Barkley, U.S. Pat. No. 4,646,741 to Smith, U.S. Pat. No. 4,671,280 to Dorband et al, U.S. Pat. No. 4,719,917 to Barrows et al and U.S. Pat. No. 4,741,337 to Smith et al are representative of such prior art devices for use in place of conventional suturing. Many of these prior art devices are made of bioabsorbable materials such that the devices are absorbed over time into the bodily tissue and do not have to be removed after the bodily tissue has healed.
There exist many compositions useful as bioabsorbable materials, as represented by the above patents and by U.S. Pat. No, 3,739,773 to Schmitt et al, U.S. Pat. No. 3,797,499 to Schneider, U.S. Pat. No. 4,141,087 to Shalaby et al, U.S. Pat. Nos. 4,300,565, 4,523,591 to Kaplan et al and U.S. Pat. No. 4,649,921 to Koelmel et al which discuss characteristics of various bioabsorbable materials and medical devices desirably manufactured of such materials, such medical devices being of a type designed to be engaged in, embedded in or otherwise attached to various types of bodily tissue, such as bone, muscle, organs, skin and other soft tissue, to remain in place in the tissue until the device is absorbed. into the body.
SUMMARY OF THE INVENTION Accordingly, it is a primary object of the present invention to provide suture devices particulary useful in endoscopic surgery overcoming the above mentioned disadvantages of the prior art.
Some of the advantages of the present invention over the prior art are that surgeons can easily and quickly utilize the suture devices during endoscopic surgery to approximate and join tissue without intricate manipulations and to provide suture stitches in a short time since the suture devices have configurations and characteristics to permit manipulation thereof in a manner similar to suture needles, endoscopic surgery can be used for additional procedures due to the reduced time required for suturing coupled with the knotting function provided by the suture devices, and the suture devices can replace conventional suturing with a length of suture material while providing all of the advantages thereof desired by surgeons.
FIGS. 1D and 1E are broken views of the body member of the sutue device of FIG. 1.
DESCRIPTION OF THE PREFERRED EMBODIMENTS A suture needle-like suture device 20 according to the present invention isillustrated in FIG. 1 and includes an elongate, curved body member 22 having a sharp distal end 24 for penetrating tissue in a manner similar toa suture needle and a bulbous enlarged proximal end 26, the elongate, curved body member 22, having a round shape in cross-section and graduallytapering from proximal end 26 to sharp distal end 24. Angled, whisker-like filaments 28 extend from the body member 22 rearwardly toward proximal end26 and are positioned around the body member and along the length thereof. The suture device 20 is made of bioabsorbable material and is intended to remain in the tissue to be absorbed therein.
The use of suture device 20 is illustrated in FIGS. 2 and 3 wherein a section of tissue 30 is to be joined to a section of tissue 32. The tissuecan be of any configuration from any anatomical part or organ of the body; however, the suture device 20 is particularly useful for various anastomosis or approximating procedures such as vascular anastomosis, bowel anastomosis, closure of anatomical or non-anatomical structures, tuboplasty and skin closure. Due to the smoothly angled orientation of thewhisker-like filaments 28, the suture device can penetrate through the tissue in only the forward direction and cannot be moved rearwardly. The sharp distal end 24 is moved to penetrate through tissue section 30 at a position spaced from the end of the tissue section in a manner similar to movement of a suture needle and is thereafter moved to penetrate through tissue section 32 at a position spaced from the end of tissue section 32. The suture device is manipulated with a conventional needle holder in a manner similar to a suture needle and can be easily utilized during endoscopic surgery; and, once the suture device has been positioned as illustrated in FIG. 2, the distal end is grasped and pulled thereby approximating the ends of the tissue sections 30 and 32 as illustrated in FIG. 3, it being noted that the enlarged bulbous proximal end 26 prevents the suture device from pulling through tissue section 30 since the proximal end has a dimension in at least one direction transverse to the body member greater than the transverse dimension of the body member. Oncethe suture device is in the position illustrated in FIG. 3 with the ends ofthe tissue sections approximated, the portion of the suture device protruding from tissue section 32 is severed as shown at line 34 leaving the suture device in the tissue. The suture device will remain in positionsince the angled, whisker-like filaments will not allow the suture device to move rearwardly and the enlarged bulbous proximal end 26 will not allowthe suture device to move forwardly. Additionally, by using a shearing cutting device to sever the protruding distal portion of the suture device, the cut end can be expanded to form a flange 35 to further preventrearward movement of the suture device. A number of suture, devices 20 may be required to provide a complete suturing procedure; and, for anastomosisor tuboplasty, as many as four, five or six suture devices may be used dependent upon the size of the tubular structure and the thickness of the wall thereof. The suture device will be absorbed in the tissue after joining and healing of the ends of the tissue sections.
By providing body member 22 with an arcuately and smoothly curving configuration, the suture device 20 can be made of a rigid bioabsorbable material in that pulling the suture device through tissue section 32 causes the suture device to essentially pivot about the proximal end 26 tomove tissue section 32 to abut tissue section 32. It will be appreciated, however, that suture device 20 can have other configurations and can be made of bioabsorbable materials of varying flexibility or rigidity for usewith particular anatomical tissues. For example, suture device 20 can be straight, or rectilinear, as shown in FIG. 1A at 20a, and made of flexiblebioabsorbable material to allow the body member 22 to bend as it is drawn through tissue section 32 to approximate the edges of the tissue sections.The proximal end 26 can have any desired configuration to prevent forward movement of the suture device once the suture device has passed through the initial tissue section; for example, the enlarged proximal end could have a flat, nail head-type shape, as shown at 26a in FIG. 1A, or the proximal end could have angled, whisker-like filaments extending forwardlytherefrom toward the sharp distal end. The body member can have a uniform diameter therealong with a tapered sharp distal end and can have various cross-sectional configurations and be either solid or hollow. The whisker-like filaments are preferred to provide the function of permittingonly forward movement of the suture device through the tissue, or, in otherwords, preventing reverse movement of the suture device; however, the body member can carry other means of permitting only forward movement such as protrusions of various configurations. By providing the whisker-like filaments along the length of the body member, the suture device 20 provides a knotting function similar to tying a knot in a length of suturematerial. That is, compression and approximation of the tissue sections canbe variably controlled in accordance with the tension applied to the suturedevice as it is pulled through the tissue by grasping the distal end 24.
The suture device 20a has rearwardly angled protrusions 28a having a truncated conical configuration to permit only forward movement of the suture device, in place of whisker-like filaments 28, the protrusions being shown in FIG. 1B with a solid body member 22a and in FIG. 1C with a hollow body member 22b. When the body member is hollow, the interior lumencan be filled with various pharmacological agents by constructing the proximal end to be detachable, such as by screw threads or a friction fit,and microholes 29 extend radially through the body member to communicate with the lumen and provide passages for the pharmacological agents to leach out into the suture site. As previously noted, the use of whisker-like or hair-like filaments to permit only forward movement of thesuture device is preferred in that, as shown in FIGS. 1D and 1E, the filaments lay against body member 22 as the suture device is moved forwardly to penetrate tissue producing minimal obstruction to smooth movement. However, any tendency for the suture device to move rearwardly causes the filaments to protrude, as shown in FIG. 1, to lock the suture device in the tissue. The body member 22 in FIG. 1D is solid while the body member in FIG. 1E is hollow to allow the interior lumen to be filled with a pharmacological agent for leaching into the suture site.
Another embodiment of a suture device according to the present invention isillustrated in FIG. 4. The suture needle-like suture device 36 is integrally formed of bioabsorbable material and includes a proximal portion 38 having an opening 40 therein defining a bottom edge 42 taperingfrom a small width at the proximal end to be progressively wider. The body of the proximal portion 38 is relatively thick and terminates at a transversely extending recess 44 which forms a hinge-like joint defining aprecise bending point from which extends a distal portion 46 tapering to a sharp, suture needle-like point 48 at the distal end of the suture device.A plurality of tapered barbs 50 extend along the distal portion 46 and, as illustrated, have truncated, tetrahedral, pyramidal shapes while other shapes could be provided as will be understood from the following discussion of the engagement of the barbs with the bottom edge 42 of the opening 40 in the proximal portion 38. For example, whisker-like filamentscan protrude from the distal portion for engaging the proximal portion. Therecess 44 allows the suture device 36 to be bent or folded about the transverse axis thereof, as illustrated in FIGS. 5 and 6, such that the proximal portion 38 and the distal portion 46 can be juxtaposed. The proximal portion 38 has a concave curved configuration and the distal portion 46 has a similar curved configuration such that, when the suture device 36 is bent of folded on itself at recess 44, the opposing ends of the suture device extend in opposite directions.
In use, the sharp point 48 is moved to penetrate sections of tissue 52 and 54 to be sutured to approximate the sections of tissue until recess 44 is positioned adjacent the tissue to limit further movement of the suture device, it being noted that the enlarged size of the proximal portion limits penetration in the tissue. The distal portion 46 is then folded in a hinge-like manner about the recess 44, and the sharp distal end 48 is passed through the opening 42 in the proximal portion such that the suturedevice 36 now has the configuration illustrated in FIG. 5. The proximal anddistal portions of the suture device are now forced towards one another such that the sharp distal end 48 passes through the opening 42 to protrude from the bottom as shown in FIG. 6. The distal end 48 can be pulled to adjustably tighten the suture device to provide a knotting function similar to tying a knot in a length of suture material with the barbs 50 engaging the bottom edge 42 of the opening 40 to lock the distal portion in place. The protruding portion of the distal end of the suture device can be severed as shown at line 56. The suture device 36 will thus hold the tissue in approximated position until the tissue is joined after which the suture device 36 will be absorbed in the body.
A modification of the suture device of FIG. 4 is illustrated in FIG. 7 and similar reference numbers with an "a" added are used to identify similar parts. The suture device 36a is made of flexible bioabsorbable material and includes a proximal portion 38a having a proximal end 58 around which is mounted a ring or ring-like member 60 having an opening 42a therethrough with a conical or tapered inner surface defining a locking edge 42a. A transversely extending recess 44a defines a hinge-like joint at the end of the proximal portion 38a, and a distal portion 46a extends from recess 44a and tapers to a sharp, suture needle-like, distal end 48a.Barbs 50a protrude from distal portion 46a angled in a direction away from distal end 48a while a plurality of similar barbs 62 protrude from proximal portion 38a in a direction toward distal end 48a such that the barbs 50a and 62 are angled toward each other prior to use of the suture device, as shown in FIG. 7, but are angled in the same direction when the suture device is bent or folded about recess 44a. The inner surfaces of proximal portion 38a and distal portion 46a are smooth or longitudinally ribbed or grooved to abut and/or lock one another when the suture device is bent at recess 44a.
In use, the sharp distal end 48a is moved to penetrate sections of tissue 52 and 54 to be sutured to approximate the sections of tissue, and the distal portion 46a is pulled through the tissue to position recess 44a adjacent the tissue as shown in FIG. 8. The distal portion is then folded in a hinge-like manner about the recess 44a such that the proximal and distal portions are juxtaposed with the sharp distal end 48a received in the opening 42a in ring 60. The ring 60 is then moved toward the joint (tothe left looking at FIGS. 8 and 9), it being appreciated that the inner surface of opening 42a tapers away from the joint such that the ring can move in only a direction toward the joint. As best shown in FIG. 9, the ring is moved in a manner similar to a knot during conventional suturing with a length of suture material until the ring is positioned as desired; and, once the ring has been properly positioned, the protruding proximal and distal portions are severed as indicated at 56a.
Suture devices 36 and 36a can have various configurations and sizes dependent upon the specific tissue to be sutured, it being important that the suture devices have a well defined bending or folding joint such that the distal portion can be folded in a hinge-like manner after penetration of the tissue to be juxtaposed along the proximal portion and engaged or interlocked with the proximal portion in an adjustable manner to provide aknotting function similar to tying knots with a length of suture material. While the distal portion is adjustably locked in an opening carried by theproximal portion in suture devices 36 and 36a, other adjustable locking means could be used as long as operation thereof can be simply effected tofacilitate use. By providing a precise bending position, use of the suture devices by the surgeon is facilitated and standardized allowing the surgeon to simply reproduce the knotting function on a plurality of stitches. Preferably, the suture devices are made of bioabsorbable materials having a hardness and rigidity increasing from the joint toward the proximal and distal ends, and the ring 60 is made of rigid bioabsorbable material.
Another embodiment of a suture needle-like suture device 62 according to the present invention is illustrated in FIG. 10 and includes an elongate body member 64 terminating at a sharp distal end 66 for penetrating tissuein a manner similar to a suture needle and at a bulbous enlarged proximal end 68, the elongate body member having a spiral configuration with the coils disposed in a single plane and having a round shape in cross-section. Angled, whisker-like filaments 70 extend from the body member rearwardly toward proximal end 26 and are positioned around the body member and along the length thereof such that the suture device 62 can pass through tissue in only a forward direction. The suture device is made of flexible, resilient bioabsorbable material such that the suture device contracts after insertion in tissue to be sutured attempting to return to its pre-suturing shape; and, accordingly, the suture device is particularly effective for closing anatomical lumens and subcuticular suturing. The spiral or coiled configuration can also circle about a central axis in curves of conical form, as shown in FIGS. 10 and 10D, or cylindrical form, as shown in FIG. 10B, dependent upon the particular use of the suture device; and, as noted above with respect to suture device 20, the proximal end can have any desired configuration, the cross-sectionof the body member can vary and the body member can carry other means of permitting only forward movement of the suture device. Additionally, the proximal end 68 can be transposed with the sharp distal end 66 such that the coils become smaller as they approach the distal end. The suture devices shown in FIGS. 10A, 10B and 10C have expanded pre-suturing states,and the coils in FIG. 10A have the same diameter while the diameter of the coils in FIG. 10B increase as they approach the distal end and the diameter of the coils in FIG. 10C decrease as they approach the distal end. Parts of the suture devices 62a, 62b and 62c of FIGS. 10A, 10B and 10C, respectively, are given reference number the same as similar parts ofsuture device 62 with "a", "b", or "c" added, and the following descriptionof use pertains to suture devices 62, 62a, 62b and 62c.
One use of suture device 62 is shown in FIG. 12 wherein an anatomical lumen72 in tissue is closed by penetrating the surrounding tissue with the sharpdistal end 66 and rotating or screwing the suture device into the tissue until proximal end 68 abuts the tissue. The suture device will be locked in place since forward movement is prevented by proximal end 68 and rearward movement is prevented by the whisker-like filaments 70, and the spiral configuration will close the lumen.
Use of the suture device 62 for subcuticular suturing is shown in FIG. 13 wherein the tissue to be sutured is skin having an outer layer 74 formed of the epidermis and the germinal epithelium and a subcutaneous layer of fat 76 primarily formed of collagen. By penetrating the subcutaneous layer76 only, and not the outer layer 74, with a series of suture devices 62, a wound or opening in the skin can be closed to facilitate healing and minimize scar tissue. The sharp distal end 66 of the suture device is moved to penetrate the subcutaneous layer 74 where the first stitch is to be taken, and the suture device is rotated to cause the suture device to advance into the subcutaneous layer until the enlarged proximal end 68 engages the tissue at which point the suture device will be locked in place with the two sides of the wound held in close engagement for healingwhile the suture device is absorbed in the tissue. Thus, suture device 62 can be simply manipulated by a surgeon to close a wound by subcutaneously suturing in a time efficient manner.
FIG. 14 illustrates use of suture device 20 of FIG. 1 for subcutaneous suturing, a series of the suture devices 20 being used in a manner similarto that described above with respect to suture device 62 with the exceptionthat only a single bite of tissue is taken with each suture device 20 as compared with the multiple bites taken with each suture device 62. The number of coils in the suture device determines the number of bites taken thereby; and, thus, it will be appreciated that the number of coils can vary as desired, suture device 20 providing one bite while suture device 62 provides five bites or stitches.
A modification of the hinge-like foldable suture devices 36 and 36a of FIGS. 4 and 7, respectively, is illustrated in FIG. 15 wherein similar parts are given similar reference numbers with a "b" added. The suture device 36b of FIG. 15 is integrally formed of bioabsorbable material and includes a proximal portion 38b having an opening 40b therein, the proximal portion 38b terminating at a transversely extending recess 44b forming a hinge-like joint defining a precise bending point from which extends a distal portion 46b tapering to a sharp, suture needle-like point48b at the distal end of the suture device. The opening 40b is formed of a tapering recess becoming gradually deeper and wider as it approaches the hinge-like joint. The width of the recess 40b is slightly less than the corresponding width of the distal portion 46b of the suture device when the suture device is folded to juxtapose the proximal and distal portions.The distal portion 46b gradually tapers to sharp distal point 48b and is faceted. Use of the suture device 36b is illustrated in FIG. 16 for suturing tissue 52, for example to occlude a tubular body part or organ. The tissue is penetrated with the sharp distal portion 46b and then foldedat recess 44b to juxtapose the distal and proximal portions as shown. The distal portion 44b can then be depressed into the recess opening 40b in anadjustable manner corresponding to the tissue being sutured, the plastic nature of the bioabsorbable material holding the distal portion within theproximal portion.
Various bioabsorbable or biodegradable materials can be used to make the suture devices of the present invention with the composition determined bythe rigidity or flexibility required. Generally, the bioabsorbable materials are thermoplastic polymers, such as absorbable polymers and copolymers of polydioxanne, lactide, glycolide and the like. Polyglycolic acid is disclosed in U.S. Pat. Nos. 3,463,158; 3,739,773 and 3,772,420. Suitable polylactic acids are disclosed in U.S. Pat. 3,636,956. Examples of absorbable polyesters are shown in U.S. Pat. Nos. 3,225,766 and 3,883,901. Absorbable cellulose glycolic acid ethers are shown in U.S. Pat. No. 2,764,159. Examples of suitable esters of alpha-cyanoacrylic acidare found in U.S. Pat. Nos. 3,527,841, 3,564,078 and 3,759,264.
From the above, it will be appreciated that the suture devices according tothe present invention have configurations to allow the suture devices to behandled or manipulated by surgeons in a manner similar to conventional suture needles. That is, the surgeon will grasp the proximal end of the suture device, for example with a needle holder, and move the suture needle to penetrate the tissue. The suture devices can be placed in the tissue in a manner to control and adjust the tension on the suture device or the compression of the tissue to produce a knotting function in an efficacious manner easily accomplished by the surgeon such that suturing and knotting can be quickly performed during endoscopic surgery.
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Jens Philipp - Semantic Scholar
N. Mai8
Joachim Hermsdörfer8
S. Glasauer6
C. Marquardt6
A Priori5
31Joachim Hermsdörfer
25Dennis A. Nowak
18Jean-Louis Thonnard
16Anne-Sophie Augurelle
14Philippe Lefèvre
The effects of digital anaesthesia on predictive grip force adjustments during vertical movements of a grasped object.
D. A. Nowak, Joachim Hermsdörfer, Stefan Glasauer, Jens Philipp, Ludger Meyer, Norbert Mai
Grip force adjustments to fluctuations of inertial loads induced by vertical arm movements with a grasped object were analysed during normal and impaired finger sensibility. Normally grip force is… (More)
Effects of changing gravity on anticipatory grip force control during point-to-point movements of a hand-held object.
D. A. Nowak, Joachim Hermsdörfer, Jens Philipp, Christian Marquardt, Stefan Glasauer, Norbert Mai
We investigated the quality of predictive grip force control during gravity changes induced by parabolic flight maneuvers. During these maneuvers gravity varied: There were 2 periods of hypergravity,… (More)
INTRODUCTION Microgravity provides unique sensory inputs to the vestibular and oculomotor systems. We sought to determine the effects of long-term spaceflight on sensing of spatial orientation. … (More)
Does eccentric endurance training improve walking capacity in patients with coronary artery disease? A randomized controlled pilot study.
Vincent Grémeaux, J Duclay, +4 authors Jean-Marie Casillas
OBJECTIVE To examine the effect of eccentric endurance training on exercise capacities in patients with coronary artery disease. DESIGN Randomized parallel group controlled study. SETTING Cardiac… (More)
Thomas Schenk, Jens Philipp, Andreas J Häußler, Alexa Hauck, Joachim Hermsdörfer, Norbert Mai
Prehensile behavior is a popular task in current research on human motor control. Most studies on reaching used stationary target objects and, therefore, most models do not address the challenges the… (More)
[Surgical results of per- and subtrochanteric femoral fractures. An overview of 15 years].
Daniela Krause, Jens Philipp, Ch. Lucke
During the last 15 years, new methods for the surgical approach to pertrochanteric and subtrochanteric fractures were developed (eg. the dynamic hip screw (DHS) and the gamma-nail (GN)). Reviewing… (More)

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value: This website is an artificial-intelligence backed search engine for academic publications developed at the Allen Institute for AI and publicly released in November 2015. It uses advances in natural language processing to provide summaries for scholarly papers.


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Sign inRita L. CardoniShareSuggest Changes66Citation Velocity591CitationsCitations Per YearE L Segura13María Inés Antúnez12M M De Bracco10M T Rimoldi10M E Rottenberg912María Inés Antúnez12Elsa Leonor Segura10Martin E. Rottenberg10M T Rimoldi9M M de BraccoFilter Results:Full text PDF available (4)Publication Year19762016Publication TypeCo-authorPublication VenueBrain RegionCell TypeKey PhrasesOrganismSort by:Highly Influential CitationsCitationsAccelerationVelocityRecencyLearn MoreEarly IFN-gamma production is related to the presence of interleukin (IL)-18 and the absence of IL-13 in experimental Trypanosoma cruzi infections.M I Antúnez, R L CardoniImmunology letters2001Gamma-interferon (IFN-gamma) production, the hallmark of the Th1 immune response, has been shown to play a central role in the resistance to Trypanosoma cruzi infections, in particular when produced in the very early acute infection. BALB/c mice infected with T. cruzi, Tulahuén strain, reach high parasitemias during the acute phase, and their spleen cells… (More)View on PubMedRelated PublicationsMore...IL-12 and IFN-gamma production, and NK cell activity, in acute and chronic experimental Trypanosoma cruzi infections.M I Antúnez, R L CardoniImmunology letters2000Resistance to acute Trypanosoma cruzi infection is mainly associated with a Th1 immune response, characterized by gamma-interferon (IFN-gamma) production and activation of macrophages. The outcome of the Th1 response in the spleen and serum of BALB/c and C3H mice infected with T. cruzi, Tulahuén strain was studied. The levels of interleukin-12 p40 (IL-12… (More)View on PubMedRelated PublicationsMore...Circulating levels of cyclooxygenase metabolites in experimental Trypanosoma cruzi infections.Rita L Cardoni, María Inés AntúnezMediators of inflammation2004Trypanosoma cruzi induces inflammatory reactions in several tissues. The production of prostaglandin F2alpha, 6-keto-prostaglandin F1alpha and thromboxane B2, known to regulate the immune response and to participate in inflammatory reactions, was studied in mice experimentally infected with T. cruzi. The generation of nitric oxide (NO), which could be… (More)View PDFRelated PublicationsMore...Release of reactive oxygen species by phagocytic cells in response to live parasites in mice infected with Trypanosoma cruzi.R L Cardoni, M I Antunez, C Morales, I R NantesThe American journal of tropical medicine and…1997The release of reactive oxygen intermediates (ROI), mediators of inflammatory reactions, was evaluated in murine Trypanosoma cruzi infection. In acutely infected BALB/c mice, spleen cells were stimulated, either with epimastigote or trypomastigote forms of the parasite, and the effect was enhanced by serum from infected mice. Only opsonized parasites… (More)View on PubMedRelated PublicationsMore...Increased production of reactive oxygen species by cells from mice acutely infected with Trypanosoma cruzi.R L Cardoni, M E Rottenberg, E L SeguraCellular immunology1990Release of reactive oxygen species (ROS) by cells from BALB/c mice was studied during the acute stage of the infection with 50 bloodstream forms of Trypanosoma cruzi, Tulahuén strain. Production of ROS by spleen and peritoneal cells was evaluated by chemiluminescence using luminol as enhancer (CL-Lum). Three to four weeks after infection, CL-Lum response… (More)View on PubMedRelated PublicationsMore...Conversion from cyclosporine A to tacrolimus in pediatric kidney transplant recipients with chronic rejection: changes in the immune responses.Jorge R Ferraris, Monica L Tambutti, Rita L Cardoni, Norma PrigoshinTransplantation2004BACKGROUND
Tacrolimus (Tac) has immunosuppressant properties similar to those of cyclosporine A (CsA), but it is more potent. At present, however, its immunosuppressive activity in renal transplant recipients with ongoing chronic rejection has not been clarified.
We studied changes in kidney function, mixed lymphocyte culture, cell-mediated… (More)View on PubMedRelated PublicationsMore...How to Improve the Early Diagnosis of Trypanosoma cruzi Infection: Relationship between Validated Conventional Diagnosis and Quantitative DNA Amplification in Congenitally Infected ChildrenJacqueline Bua, Bibiana J. Volta, +5 authors Rita L. CardoniPLoS neglected tropical diseases2013BACKGROUND
According to the Chagas congenital transmission guides, the diagnosis of infants, born to Trypanosoma cruzi infected mothers, relies on the detection of parasites by INP micromethod, and/or the persistence of T. cruzi specific antibody titers at 10-12 months of age.
Parasitemia levels were quantified by PCR in… (More)View PDFRelated PublicationsMore...Role of T helper/inducer cells as well as natural killer cells in resistance to Trypanosoma cruzi infection.M Rottenberg, R L Cardoni, R Andersson, E L Segura, A OrnScandinavian journal of immunology1988T lymphocytes provide a major line of defence against many protozoan parasites. The aim of this work was to determine the role of T-cell helper/inducer subset (T h/i) in the resistance to Trypanosoma cruzi in a murine model. The importance of natural killer (NK) cells in the resistance to the parasite was also evaluated. BALB/c and C57BL/6 mice were… (More)View on PubMedRelated PublicationsMore...The neuromuscular pathology of experimental Chagas' disease.H A Molina, R L Cardoni, M T RimoldiJournal of the neurological sciences1987In this work, we describe skeletal muscle, neuromuscular junction, nerve and spinal cord lesions in the mouse model system of Chagas' disease. Myositis was a common finding and Trypanosoma cruzi amastigote nests were frequently found in the muscle fibers. Angular atrophy, targetoid fibers, groups of atrophic fibers, fibrosis, myofiber necrosis and… (More)View on PubMedRelated PublicationsMore...Proinflammatory and anti-inflammatory cytokines in pregnant women chronically infected with Trypanosoma cruzi.R L Cardoni, M Martín García, A M De RissioActa tropica2004Mother-to-child transmission of intracellular parasites could be related to the production of immunoregulatory cytokines. The levels of gamma interferon (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) and lnterleukin (IL)-10 were evaluated during pregnancy in sera of women chronically infected with Trypanosoma cruzi that delivered infected or… (More)View on PubMedRelated PublicationsMore...‹12345›The Allen Institute for Artificial IntelligenceProudly built by AI2 with the help of our Collaborators using these Sources.Terms of Service•Privacy Policy.


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Guesthouse Sveta, Dilijan – Updated 2018 Prices
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St. Kamo, h.125a 1, 3904 Dilijan, Armenia – Show map
Located in Dilijan, Guesthouse Sveta features a garden. Free WiFi is included.
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Patent US5735825 - Syringe plunger tip - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA sealing cap is provided for attachment to the end of a syringe plunger. The sealing cap has an annular sidewall with an annular first sealing wing projecting distally therefrom, an annular second sealing wing positioned proximal of the first sealing wing and projecting proximally, and an annular sealing...http://www.google.com/patents/US5735825?utm_source=gb-gplus-sharePatent US5735825 - Syringe plunger tipAdvanced Patent SearchPublication numberUS5735825 APublication typeGrantApplication numberUS 08/620,386Publication dateApr 7, 1998Filing dateMar 22, 1996Priority dateMar 22, 1996Fee statusPaidPublication number08620386, 620386, US 5735825 A, US 5735825A, US-A-5735825, US5735825 A, US5735825AInventorsBrian W. Stevens, Darryl Kent Backman, Garlyn W. HendryOriginal AssigneeMerit Medical Systems, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (9), Referenced by (106), Classifications (8), Legal Events (8) External Links: USPTO, USPTO Assignment, EspacenetSyringe plunger tip
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Ltd.Slide member for syringe or cartridgeWO2001030421A2 *Oct 27, 2000May 3, 2001Minimed, Inc.Plunger plug with stiffening insertWO2001030421A3 *Oct 27, 2000Jan 10, 2002Minimed IncPlunger plug with stiffening insertWO2002002164A1 *Jun 8, 2001Jan 10, 2002Animas CorporationInfusion pump syringeWO2003093108A1 *Apr 4, 2003Nov 13, 2003Comar, Inc.Dispenser for medicaments and method and apparatus for making sameWO2014190225A1 *May 23, 2014Nov 27, 2014Sio2 Medical Products, IncSyringe assembly and barrel for use in such an assemblyWO2014208446A1 *Jun 19, 2014Dec 31, 2014En Otsuka Pharmaceutical Co., Ltd.Syringe and fluid substance transfer tool* Cited by examinerClassifications U.S. Classification604/218, 604/222International ClassificationA61M5/315, A61M5/31Cooperative ClassificationA61M2005/31521, A61M5/31513, A61M5/3137European ClassificationA61M5/315C1Legal EventsDateCodeEventDescriptionMar 22, 1996ASAssignmentOwner name: MERIT MEDICAL SYSTEMS INC., UTAHFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:STEVENS, BRIAN W.;BACKMAN, DARRYL KENT;HENDRY, GARLYN W;REEL/FRAME:007938/0046Effective date: 19960321Feb 16, 1999CCCertificate of correctionOct 5, 1999ASAssignmentOwner name: ZIONS FIRST NATIONAL BANK, UTAHFree format text: SECURITY AGREEMENT;ASSIGNOR:MERIT MEDICAL SYSTEMS, INC.;REEL/FRAME:010281/0626Effective date: 19990811Oct 5, 2001FPAYFee paymentYear of fee payment: 4Oct 7, 2005FPAYFee paymentYear of fee payment: 8Sep 22, 2009FPAYFee paymentYear of fee payment: 12Dec 13, 2012ASAssignmentOwner name: MERIT MEDICAL SYSTEMS, INC., UTAHFree format text: RELEASE BY SECURED PARTY;ASSIGNOR:ZIONS FIRST NATIONAL BANK;REEL/FRAME:029461/0429Effective date: 20121212Jan 25, 2013ASAssignmentOwner name: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISFree format text: PATENT SECURITY AGREEMENT;ASSIGNOR:MERIT MEDICAL SYSTEMS, INC.;REEL/FRAME:029698/0033Effective date: 20121219RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services

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