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Many functions provided by the standard C library can be dangerous to use. A new library has been created that provides an alternative which is considered to be more safe: the C Library Wrapper. The objective of the safety library is simple: provide more LUT
LeakML Memory Leak Detection is a C library for detecting and reporting memory leaks. LeakML was design to be non-intrusive to the application and portable. Its output is in XML to allow any XML parsing frontend to replay the debugging session. LeakML MONDO

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Ellen Margaret Ruby Beckman (1913-2003) - Find A Grave Memorial
Ellen Margaret Ruby Beckman
11454294 · View Source
Thomas Frederick Ruby
Martha Helen Bengen Ruby
John Lee Beckman
1911–2002 (m. 1929)
Martin Frederick Ruby*
Find A Grave Memorial 11454294
Find A Grave, database and images (https://www.findagrave.com : accessed ), memorial page for Ellen Margaret Ruby Beckman (13 Mar 1913–2 Oct 2003), Find A Grave Memorial no. 11454294, citing Pleasant Ridge Cemetery, Plattsmouth, Cass County, Nebraska, USA ; Maintained by Ken Beckman (contributor 46796938) .
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Patent US5280093 - Chiral polymers for the synthesis of pure enantiomers of amino acids - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsThe present invention relates to chiral polymers and to their uses for operations of asymmetric synthesis, deracemization and optical inversion. These polymers are characterized in that they comprise: a chiral unit a functionalizing unit an optional crosslinking unit Application to chiral organic sy...http://www.google.com/patents/US5280093?utm_source=gb-gplus-sharePatent US5280093 - Chiral polymers for the synthesis of pure enantiomers of amino acidsAdvanced Patent SearchPublication numberUS5280093 APublication typeGrantApplication numberUS 08/047,001Publication dateJan 18, 1994Filing dateApr 14, 1993Priority dateJun 29, 1989Fee statusPaidPublication number047001, 08047001, US 5280093 A, US 5280093A, US-A-5280093, US5280093 A, US5280093AInventorsRobert Jacquier, Monique Calmes, Jacques DaunisOriginal AssigneeRhone-Poulenc ChimieExport CitationBiBTeX, EndNote, RefManPatent Citations (11), Non-Patent Citations (25), Referenced by (7), Classifications (17), Legal Events (3) External Links: USPTO, USPTO Assignment, EspacenetChiral polymers for the synthesis of pure enantiomers of amino acids
US 5280093 AAbstract
The present invention relates to chiral polymers and to their uses for operations of asymmetric synthesis, deracemization and optical inversion.
These polymers are characterized in that they comprise:
a chiral unit
a functionalizing unit
an optional crosslinking unit
Application to chiral organic synthesis.
1. Polymer obtained by copolymerization of at least one chiral unit and at least one functionalizing agent having a protective function, each chiral unit being a chiral monomer selected from one of two stereoisomers, R and S, having a chiral carbon, a molecular weight equal to at most 200, and possessing a polymerizable double bond with the number of atoms between said double bond and said chiral carbon being at most 5, said polymerization taking place through said double bond of said chiral monomer, wherein said chiral unit represents, expressed in moles, a ratio at least equal to one-half of said polymer; wherein, if two or more chiral units are copolymerized with said functionalizing agent, substantially all of the chiral units are of the same configuration, either R or S; wherein said functionalizing agent comprises an aromatic aldehyde group; and wherein said functionalizing agent comprises said chiral monomer and a protective group, with the proviso that the chiral monomer is other than 1-acryloyl-2-methoxymethylpyrrolidine.
2. Polymer according to claim 1 wherein said polymer includes a crosslinking agent.
3. Polymer according to claim 1, wherein said chiral unit represents, expressed in moles, a ratio equal to at least two-thirds of said polymer.
4. Polymer according to claim 1, wherein said chiral unit represents, expressed in moles, a percentage equal to at least 70% of said polymer.
5. Polymer according to claim 1, characterized in that said chiral unit represents, expressed in moles, a ratio equal to at least three-fourths of said polymer.
6. Polymer according to claim 1, wherein said chiral unit comprises at least one functional group capable of forming a hydrogen bond with a second identical chiral unit.
7. Polymer according to claim 6, wherein said functional group capable of forming a hydrogen bond is an acidic, alcohol, amide, or amine functional group.
8. Polymer according to claim 6, wherein said functional group capable of forming a hydrogen bond is an alcohol functional group.
9. Polymer according to claim 1, wherein said aromatic aldehyde group is a benzaldehyde roup.
10. Polymer according to claim 1, wherein said aromatic aldehyde group is an aminobenzaldehyde group.
11. Polymer obtained by copolymerization of at least one chiral unit and at least one functionalizing agent having a protective function, each chiral unit being a chiral monomer selected from one of two stereoisomers, R and S, having a chiral carbon, a molecular weight equal to at most 200, and possessing a polymerizable double bond with the number of atoms between said double bond and said chiral carbon being at most 5, said polymerization taking place through said double bond of said chiral monomer; wherein said chiral unit comprises at least one functional group capable of forming a hydrogen bond with a second identical chiral unit; wherein, if two or more chiral units are copolymerized with said functionalizing agent, substantially all of the chiral units are of the same configuration, either R or S; wherein said functionalizing agent comprises an aromatic aldehyde group; and wherein said functionalizing agent is a monomer which does not comprise said chiral monomer, with the proviso that the chiral monomer is other than 1-acryloyl-2-methoxymethyl-pyrrolidine.
12. Polymer according to claim 11, wherein said polymer includes a crosslinking agent.
13. Polymer according to claim 11, wherein said chiral unit represents, expressed in moles, a ratio equal to at least one-half of said polymer.
14. Polymer according to claim 11, wherein said chiral unit represents, expressed in moles, a ratio equal to at least two-thirds of said polymer.
15. Polymer according to claim 11, wherein said chiral unit represents, expressed in moles, a ratio equal to at least three-fourths of said polymer.
16. Polymer according to claim 11, wherein said chiral unit is a chiral monomer selected from one of two stereoisomers, R and S, of N-acryloyl-prolinol, wherein said functionalizing agent is para-(N-acryloyl-N-methylamino)benzaldehyde, and wherein one or more of the acryloyl groups is optionally replaced, either in the chiral unit or in the functionalizing agent, by a methacryloyl group.
17. Polymer according to claim 16, wherein none of the acryloyl groups is optionally replaced by a methacryloyl group.
18. Polymer according to claim 16, wherein said polymer includes a crosslinking agent.
19. Polymer according to claim 18, wherein said crosslinking agent is selected from the group consisting of bis(acryloyl)-N,N'-dimethylethylenediamine and bis(acryloyl)piperizine, wherein any acryloyl group may be replaced by a methacryloyl group.
20. Polymer according to claim 19, wherein the acryloyl group of the crosslinking agent is replaced by a methacryloyl group.
21. Polymer according to claim 19, wherein said crosslinking agent is bis(acryloyl)-N,N'-dimethylethylenediamine.
22. Polymer according to claim 11, wherein said functional group capable of forming a hydrogen bond is an acidic, alcohol, amide, or amine functional group.
23. Polymer according to claim 11, wherein said functional group capable of forming a hydrogen bond is an alcohol functional group.
24. Polymer according to claim 11, wherein said aromatic aldehyde group is a benzaldehyde group.
25. Polymer according to claim 11, wherein said aromatic aldehyde group is an aminobenzaldehyde group.
26. Polymer according to claim 11, wherein said functionalizing agent is para-(N-acryloyl-N-methylamino)benzaldehyde.
This application is a continuation of application Ser. No. 07/915,758, filed Jul. 21, 1992, now abandoned, which is a continuation of application Ser. No. 07/545,526, filed Jun. 29, 1990, all abandoned.
The present invention relates to chiral polymers permitting the asymmetric synthesis, on a support, of amino acids, as well as to new processes for the synthesis of enantiomerically pure amino acids.
There are few examples in the prior art of asymmetric syntheses supported on a polymer. Their principle remains the same as in solution, requiring the presence of a chiral auxiliary in proximity to the prochiral center. Utilizing polystyrene supports in all cases, these examples relate to asymmetric syntheses of hydroxy acids (KAWANA and EMOTZ, Bull. Chem. Soc. Japan, 1974, 47, 160); of arylaliphatic esters (MCMANUS et al., J. Org. Chem. 1981, 46, 3097) and of 2-methylcyclohexanone (LEZNOFF et al., Canad. J. Chem., 1982, 60, 1836; FRECHET et al., Reactive Polymers, 1983, 1, 227). However, if the work of LEZNOFF et al. (loc. cit.) is excepted, the enantiomeric excesses remain average (56-62%). Finally, LEZNOFF et al. (Canad. J. Chem., 1982, 60, 2984) carried out the asymmetric protonation of the lithium enamine of racemic 2-methylcyclohexanone anchored to the chiral arm of a polystyrene.
Another strategy consists in utilizing a chiral polyacrylic support producing a supramolecular asymmetric induction (CALMES, DAUNIS, JACQUIER, NKUSI, VERDUCCI and VIALLEFONT, Tetrahedron Letters, 1986, 27, 4303).
However, when this strategy is applied to the synthesis of amino acids, it is necessary to work at very low temperature (-78� C.).
Under these conditions, in the synthesis of amino acids, enantiomeric excesses have not exceeded 63% in alkylations of enolates carried out at -78� C.
For this raason, one of the objects of the present invention is to provide a family of polymers which can be utilized for deracemizing or changing from one enantiomer to the other.
For this reason, one of the objects of the present invention is to provide a process for synthesis or deracemization utilizing the above polymers.
The subject of the present invention is a polymer which can, in particular, be obtained by the free-radical copolymerization of a chiral monomer or oligomer or prepolymer, a functionalizing agent and preferably a crosslinking agent, characterized in that it contains:
an optional crosslinking unit.
The chiral unit represents, expressed in moles, a large percentage which varies according to the chemical properties of the chiral unit. When the chiral unit does not possess sites (sic) capable of forming intramolecular hydrogen bonds with another chiral unit, it is desirable that the chiral unit represents at least 2/3, and advantageously 70%, of the total units, and preferably 3/4. When the chiral unit possesses sites capable of forming hydrogen bonds between two chiral units, the percentage can be significantly smaller. It is, however, preferable that at least 1/2, and preferably 2/3, of the units are chiral.
Although it is possible to envisage units obtained by polycondensation, such as, for example, an amide unit as in polyamides or an ester unit as in polyesters, the most suitable chiral unit is a unit which can be obtained by the polymerization of chiral monomers possessing an unsaturated bond.
The chiral monomers may be obtained by the grafting of a group bearing unsaturation onto chiral groups; for the purpose of teaching, for example, there may be mentioned:
The monomers obtained by the amidation or esterification of acrylic acids, optionally substituted, by means of optically active molecules in which the asymmetric carbon is advantageously well exposed, as in the case where the active carbon forms part of a ring.
The coupling of the chiral derivatives with the acrylic radical may be carried out by means of an amide functional group (for example with amino acids or their derivatives such as, for example, the amides and esters) or an ester functional group. It may also be carried out by any technique known to those skilled in the art, for example vinyl groups may be grafted onto the aromatic rings of chiral derivatives possessing the latter, such as, for example, derivatives of phenylalanine and tryptophan and adrenaline derivatives and the like.
The chiral monomer may also be obtained by reciprocal coupling systems, such as, for example, the manufacture of enol esters from optically active acids such as amino acids, or of enol ether from an alcohol possessing an active group. It is also possible to utilize compounds possessing asymmetric carbons and a polymerizable double bond, after optical resolution where appropriate.
It is preferable that, in the chiral monomer generating the chiral unit, the double bond is close to the asymmetric carbon, more specifically it is preferable that the number of atoms between the double bond and the chiral center is at most equal to 5, preferably to 3 and most preferably to 2.
Moreover, the chiral unit advantageously possesses at least one functional group bearing hydrogen capable of forming hydrogen bonds with another chiral unit of the same kind. Among functional groups, acidic functional groups, alcohol functional groups including phenols, amide functional groups and amine functional groups may be mentioned.
Among chiral units usually employed, there may be mentioned, by way of examples, the acrylamides, optionally substituted at the acryl group, formed from the following amines:
prolinol, and optionally its derivatives in the form of esters or ethers of the alcohol functional group,
1-amino-1-phenylethanes, in particular 1-(N-methylamino)-1-phenylethane,
1-(N-alkylamino)-2-alkoxypropane in which the alkyl or alkoxy groups can represent linear or branched alkyls, preferably a methyl or a hydrogen,
1-pyrrolidinyl-2-methylpyrrolidine,
1-amino-1-alkyl-2-hyiroxyethane and its derivatives mono- or dimethylated on the nitrogen and on the alcohol. The derivative disubstituted on the nitrogen naturally being excluded since it is incapable of forming an amide bond with the acryl group (however it could be used if an acrylic ester is utilized as a chiral monomer).
Generally speaking, it is preferable that the chiral monomer generating the chiral unit is of low molecular weight, that is to say advantageously at most equal to 200, and preferably at most equal to approximately 150.
The functionalizing unit can be any unit bearing protective functions as defined in works well known to those skilled in the art, such as the work by Theodore W. Greene "Protective Groups in Organic Synthesis" published by John WILEY and SONS, 1981, and that by J.F.W. McOmie, "Protective Groups in Organic Chemistry" published by PLENUM PRESS, LONDON AND NEW YORK, 1973.
The protective groups may be converted to monomers giving functionalizing units in the same manner, when the appropriate changes are made, as in the case of the monomers and the chiral units. Thus, anilide groups converted to acrylanilides bearing said protective groups as defined above may be used as monomers generating the functionalizing units. Among protective groups giving the best results, aminobenzaldehyde derivatives, which are especially useful in the synthesis or deracemization of (primary) amino derivatives such as amino acids, may be mentioned.
Acryloyl derivatives (including methacryloyl derivatives), the derivatives derived by amidation with acrylic acids of the following derivatives:
CH3 --NH--C(R1)(R2)--CHO
with R1 or R2 aryl or aralkyl, may be mentioned.
It is also possible to devise the situation where the functionalizing units are units derived from the polymerization of chiral units of the above type, but onto which the envisaged protective function has been grafted.
It is very highly preferable that the polymer according to the present invention also contains crosslinking units. These crossbonding units are derived from monomers in general bearing 2 unsaturated bonds. These monomers are well known to those skilled in the art in the polymer field. Diesters or diamides of acrylic acids, obtained by the action of acrylating reagents on dialcohols or diamides, may be utilized in particular.
The different monomers are selected according to techniques well known to those skilled in the art so as to be compatible for the purpose of a smooth polymerization. The polymerization is not the only criterion; it is also advisable that the monomers do not interact with one another from a chemical standpoint. The molar percentage of the crosslinking agent is advantageously between 0 and 20% of the chiral unit, and preferably from 5 to 15, the functionalizing unit constituting the remainder of this functionalized chiral polymer.
Sequences of chiral monomer may be inserted into a non-chiral polymer.
The different monomers are selected in such a way that the mass ratios, compatible with the mole ratios given above, are advantageously between 50 and 65% for the chiral unit, between 5 and 15% by weight for the crosslinking unit and between 40 and 25% for the functionalizing unit.
The synthesis of the polymers according to the present invention is carried out according to techniques well known to those skilled in the art. Those which form the subject of Examples 1 to 3 may be taken as a paradigm.
The chiral polymers according to the present invention permit asymmetric synthesis, deracemization and optical inversion. The optical isomer obtained depends on the choice of the R or S form of the chiral monomer.
In the description which follows, the reactions of asymmetric synthesis and optical inversion will be utilized on amino acids as a paradigm of what it is possible to carry out by means of the monomer according to the present invention. In effect, the syntheses described below are well known to those skilled in the art, and have been described and exemplified numerous times in the scientific literature. The invention consists in carrying out the reactions of synthesis, inversion or racemization on the polymer according to the present invention, thereby enabling pure optically active compounds to be obtained and permitting deracemization or inversion according to techniques which usually permit racemization.
The subject of the present invention is, in addition, a process for the asymmetric synthesis, on a support, of amino acids from a prochiral derivative of general formula: ##STR1## in which n is equal to 0 or 1. R1 represents a hydrogen atom or an alkyl or aralkyl group, and
R2 represents a linear or branched C1 to C5 alkyl group or an aryl group,
which derivative is reversibly anchored, for example by the formation of a Schiff's base, to a chiral polymer functionalized with an aldehyde or the like, characterized in that:
in a first step, the derivative bonded to the chiral polymer is deprotonated with a strong base in a solvent, preferably aprotic and preferably polar, such as, for example, tetrahydrofuran;
in a second step, either alkylation or protonation of the deprotonated derivative bonded to the chiral polymer is performed, so as to create or recreate an asymmetric carbon on said derivative, and
in a third step, the Schiff's base is hydrolyzed to obtain an amino acid of general formula: ##STR2## where R1 and n are as defined above, and R3 represents an alkyl or aralkyl group,
R1 and R3 necessarily being different.
As a strong base, amides such as lithium diisopropylamide or lithium tetramethylpiperide, the lithium salt of hexamethyldisilazane, anions derived from alkanes, such as butyllithium, and alcoholates such as potassium tert-butylate. This list is not exhaustive.
According to a preferred embodiment of the process according to the present invention, protonation of the deprotonated derivative bonded to the chiral polymer is performed by adding water, an alcohol or an inorganic or organic acid.
According to a preferred embodiment of the process according to the present invention, alkylation of the deprotonated derivative bonded to the chiral polymer is performed with a halide of general formula R3 X, where X represents Cl, Br or I and R3 is as defined above. R3 can also be a functionalized group of the type
Z--(CH2)n --
in which n=1 to 4
Z=I, CN, CO2 R4 (R4 =alkyl), OR5 (R5 =CH3, tosyl, tetrahydropyranyl),
Y--NH (Y=benzyloxycarbonyl, t-butyloxycarbonyl), R4 S, ##STR3##
The deprotonated derivative bonded to the chiral polymer can also react:
in aldolization and ketolization reactions with R6 CHO (R6 =alkyl, aryl or aralkyl) and with aliphatic or arylaliphatic ketones,
in 1,4-addition reactions with acrylic esters, acrylonitrile or acrolein.
According to an especially advantageous arrangement of this preferred embodiment of the process according to the present invention, the deprotonated derivative bonded to the chiral polymer is reacted with the halide R3 X for 1h to 4h.
To obtain, by the process according to the present invention, one or other of the two enantiomers of an amino acid, with an enantiomeric excess of more than 95%, the chiral polymer containing one of the two isomers, R or S, of N-acryloylprolinol is selected, according to the enantiomer desired.
In addition, by means of the use of a new support polymer in which the chiral bond is N-acryloylprolinol, it is possible to equilibrate the intermediate enolates without the need to work at low temperature.
The result of this is that, in contrast to the processes described in the prior art, which can be carried out only at very low temperatures, of the order of -70� to -80� C., the process according to the present invention may be carried out entirely at room temperature, and that it is even possible, surprisingly, to improve its outcome by a step of heating to moderate temperature, of the order of 60� to 70� C.
According to a preferred embodiment of the process according to the present invention, the asymmetric synthesis of amino acids on a support is performed at a temperature above 0� C.
According to another preferred embodiment of the process according to the invention, the derivative bonded to the polymer is heated to the refluxing temperature of tetrahydrofuran (67� C.) at the end of the first step for a period of 15 min to 4h.
Apart from the foregoing arrangements, the invention also comprises other arrangements which will become apparent from the description which follows.
The present invention will be better understood by means of the further description below, which relates to examples of preparation of the chiral support polymer, and to examples of embodiments of the process for the asymmetric synthesis of amino acids according to the present invention.
It should be clearly understood, however, that these examples are given only by way of illustration of the subject of the invention, and in no way constitute a limitation of the latter.
The enantiomeric excesses (ee) are determined either by measurement of the optical rotations, or preferably using Marfey's reagent (Carlsberg Res. Comm., 1984, 49, 591) which permits separation of the diastereoisomers by reversed-phase HPLC with excellent precision.
I--PREPARATION OF A CHIRAL SUPPORT POLYMER
10.1 g (0.065 mole) of (R)- or (S)-N-acryloylprolinol, 1.3 g of bis(acryloyl)-N,N'-dimethylethylenediamine and 3.6 g (0.019 mole) of N-acryloyl-N-methyl-p-aminobenzaldehyde are added to 30 ml of tetrahydrofuran, followed by the addition of 1.5 g of azoisobutyronitrile. The mixture is heated for 1 h to reflux, cooled to room temperature and filtered. The product is washed successively with EtOH+10% of ether and with CH2 Cl2 +10% of ether. The residue is suspended in 50 ml of ether and the lumps are broken up with a spatula. The product is filtered off and dried under vacuum over P2 O5 at room temperature. It is sieved between 0.08 mm and 0.2 mm. Yield 90-95%.
The load, measured by oxime formation, is 1.1 meq CHO per gram.
The same quantities of the three monomers utilized in Example 1 are dissolved in a 1:1 mixture of alcohol and water. After degassing with a sonic probe, a stream of nitrogen is bubbled through for 15 min. A solution of 0.3 g of ammonium persulfate in 1 ml of water is then added, followed, after homogenization, by the addition of 0.3 ml of tetramethylethylenediamine. The mixture is homogenized and, after a few minutes, the temperature rises by 4� to 7� C.
The mixture is left for 1 h and filtered and the product is washed with acetone and alcohol. The resin is suspended in ether and the procedure is as in Example 1. Yield 90-95% after sieving. Load identical to that of Example 1.
Paraffin oil (400 ml) and sorbitane trioleate (Fluka SPAN� 85) (0.3 ml) are introduced into a 2-1 cylindrical reactor equipped with a stirrer and a nitrogen inlet. A strong stream of nitrogen is bubbled through for 30 minutes before the introduction of (R)- or (S)-N-acryloylprolinol (0.12 mole), bis(acryloyl)-N,N'-dimethylethylenediamine (0.013 mole) and N-acryloyl-N-methyl-p-aminobenzaldehyde (0.035 mole), these compounds being diluted in water (110 ml) and ethanol or dimethylformamide (110 ml). The mixture is stirred under a slow stream of nitrogen and the stirrer speed is adjusted until the suspended drops reach a diameter in the region of 0.1 mm. A solution of 0.5 g of ammonium persulfate in 1 ml of water is then added, followed by the addition of 0.36 ml of tetramethylethylenediamine. After a short induction period, the temperature rises to around 30� C. After 30 min, the mixture is diluted with petroleum ether. The polymer beads are collected on a Buchner covered with a nylon mesh (100 um), washed copiously successively with petroleum ether, acetone, aqueous acetone (1:1), water, ethanol and ether and finally dried under vacuum over P2 O5 at room temperature. Yield 90-95% of resin beads (diameter between 0.1 and 0.2 mm). Load identical to that of Example 1.
II ASYMMETRIC SYNTHESIS OF AMINO ACIDS
10 g of copolymer obtained in Examples 1, 2 or 3 from (S)-prolinol and 2.9 g of racemic t-butyl alaninate in 150 ml of toluene and a few drops of boron trifluoride etherate are heated to reflux, removing the water formed by means of a Dean and Stark trap. When the reaction is complete, the mixture is allowed to return to room temperature and the resin is filtered off, washed with dichloromethane and ether and dried under vacuum over P2 O5 at room temperature.
To a stirred suspension of the Schiff's base thereby obtained, in 200 ml of anhydrous tetrahydrofuran, a solution of lithium diisopropylamide (50 moles) in 90 ml of tetrahydrofuran is added at room temperature. The mixture is heated for 2 h under reflux and cooled to 20� C., 40 ml of water are added and the mixture is left for 2 h. The resin is then filtered off and copiously washed successively with tetrahydrofuran, dichloromethane and anhydrous ether.
A suspension of the above resin in 200 ml of 1.5 N hydrochloric acid is stirred for 4 h at room temperature. The solid is filtered off and washed with 200 ml of water, and the filtrates are combined and concentrated to dryness under vacuum.
The residue of amino acid hydrochloride is stirred for 1 h with 10 ml of hexamethyldisilazane. The insoluble matter is filtered off and 20 ml of methanol are added to the filtrate; after 10 min, the solvent is evaporated off and the residue of (R)-alanine is dried under vacuum. Yield 95-97%; enantiomeric excess (determined by polarimetry) 96-98%.
The recovered resin can be recycled after drying.
The same operation as in Example 4 is carried out with a polymer prepared from (R)-prolinol. (S)-Alanine is obtained with the same chemical yield and the same enantioselectivity.
The same procedure as in Example 4 is carried out, but the whole deprotonation and reprotonation reaction is performed at -78� C. (R)-Aniline is obtained with an ee=61%.
The same operation as in Example 4 is carried out, but starting with t-butyl (RS)-valinate. (R)-Valine is obtained with a 95-97% yield and an ee =98-99%.
Same operation as in Example 4, but the supported Schiff's base is prepared from t-butyl glycinate. After formation of the enolate by the action of lithium diisopropylamide in tetrahydrofuran at 20�, the mixture is heated for 2 h under reflux and cooled to 20�, 15 moles of methyl iodide in 10 ml of tetrahydrofuran are added dropwise and the mixture is left for 2 h.
After treatment as described in Example 4, (S)-alanine is isolated with a 95-97% yield and an ee=98-99%.
Same procedure as in Example 8, utilizing a copolymer prepared from (R)-prolinol. Under these conditions, (R)-alanine is isolated with the same yield and the same enantioselectivity as in Example 8.
Same procedure as in Example 8, but avoiding bringing the enolate to reflux. (S)-Alanine is obtained with an ee=82%.
In each of the processes illustrated by the examples above, around ten recyclings of the polymer were carried out without loss of yield or of enantio-selectivity.
As is apparent from the foregoing, the invention is in no way limited to those of its embodiments and methods of implementation and application which have just been described more explicitly; it encompasses, on the contrary, all variants which may occur to the specialist in the field, without falling outside the scope or the range of the present invention.
The same operation as in Examples 4 and 7 is carried out starting with t-butyl (RS)-phenylalaninate. (R)-Phenylalanine is obtained with a 95-97% yield and an ee>99%.
The same operation as in Example 8 is carried out, but replacing methyl iodide by isopropyl iodide.
After treatment as described, (S)-valine is isolated with a 95-97% yield and an ee>99%.
The same operation as in Example 8 is carried out, but replacing methyl iodide by benzyl bromide. (S)-Phenylalanine (sic) is isolated with a 95-97% yield and an ee>99%.
The same operation as in Example 4 is carried out, but starting with t-butyl (S)-alaninate. (R)-Alanine is obtained with a quantitative yield and with an ee>99%.
The same operation as in Example 4 is carried out, but utilizing the N-acryloyl derivative of (R)-methylbenzylamine as a bond agent. Utilizing 5 equivalents of LDA, (R)-alanine is isolated with a 95% yield and an ee=86%. The ee falls to 37% if 1 equivalent of LDA is employed.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4138542 *Apr 28, 1978Feb 6, 1979Basf AktiengesellschaftPolymers which contain 2-(4-methyl-cyclohex-3-en-1-yl)-propyl-N-acrylamide or -N-methacrylamide groupsUS4156765 *Feb 27, 1978May 29, 1979Basf AktiengesellschaftOptically active polymers containing methylpinane groupsUS4315089 *Nov 13, 1979Feb 9, 1982Basf AktiengesellschaftPolymers containing aromatic aldehyde groupsUS4424312 *Mar 16, 1981Jan 3, 1984Polymer Sciences CorporationPreparation of amino acids in high optical yield via catalytic hydrogenationUS4436874 *Nov 10, 1982Mar 13, 1984Societe D'expansion Scientifique "Expansia"Acrylic copolymers and their use in solid phase peptide synthesisUS4439545 *Nov 10, 1982Mar 27, 1984Societe D "Expansion Scientifique "Expansia"Acrylic copolymers of N-acryloylpolymethyleneimines or N-acryloyldialkylamides, N,N'-acryloyldiaminoalcanes and N-acryloylaminoacids (or esters) their preparation and use as cation exchangersUS4604451 *Nov 13, 1984Aug 5, 1986Nitto Boseki Co., Ltd.Novel functionalized resin derived from polyallylamineUS4914159 *Mar 1, 1988Apr 3, 1990Bayer AktiengesellschaftOptically active (meth)acrylamides, a process for their preparation, and their use for racemate resolutionUS4931525 *Nov 21, 1988Jun 5, 1990Bayer AktiengesellschaftOptical active (meth)acrylamides and polymers thereof for racemate resolutionEP0300448A2 *Jul 20, 1988Jan 25, 1989Mitsubishi Kasei CorporationSeparation mediumFR2515645A1 * Title not available* Cited by examinerNon-Patent CitationsReference1"Harrap's French and English Science Dictionary," Dr. D. E. Hathway (Consultant Editor), Harrap Limited, Great Britain, 1985, p. 167.2"Organic Chemistry," Robert T. Morrison and Robert N. Boyd, Allyn and Bacon, Inc., Fifth Edition, 1987, pp. 131-132.3Calmes et al., "Supramolecular Asymmetric Induction : A New Concept Applied to the Supported Enantioselective Synthesis of α'-Amino Acids," Tetrahedron, 46:6021-6032 (1990).4 *Calmes et al., Supramolecular Asymmetric Induction : A New Concept Applied to the Supported Enantioselective Synthesis of Amino Acids, Tetrahedron, 46:6021 6032 (1990).5Colwell et al., "Synthesis of Carboxylic Acids and Esters Using Polymer-Bound Oxazolines," J. Org. Chem., 46:3097-3102 (1981).6 *Colwell et al., Synthesis of Carboxylic Acids and Esters Using Polymer Bound Oxazolines, J. Org. Chem., 46:3097 3102 (1981).7Frechet et al., "Polymer Assisted Asymmetric Reactions.II.*Synthesis and Application of a Crosslinked Resin Containing (R)-1-(4-Vinylphenyl)Ethylamine," Reactive Polymers, 227-235 (1982).8 *Frechet et al., Polymer Assisted Asymmetric Reactions.II.*Synthesis and Application of a Crosslinked Resin Containing (R) 1 (4 Vinylphenyl)Ethylamine, Reactive Polymers, 227 235 (1982).9 *Harrap s French and English Science Dictionary, Dr. D. E. Hathway (Consultant Editor), Harrap Limited, Great Britain, 1985, p. 167.10 *J. March, Advanced Organic Chemistry, 2nd Ed., 1977, pp. 816 819.11J. March, Advanced Organic Chemistry, 2nd Ed., 1977, pp. 816-819.12Kawana et al., "Asymmetric Synthesis with Sugar Derivatives. V.1,2) The Synthesis of α-Hydroxy Acids on Insoluble Polymer Supports," Bull. Chem. Soc. Japan, 47:160-165 (1974).13 *Kawana et al., Asymmetric Synthesis with Sugar Derivatives. V. 1,2 ) The Synthesis of Hydroxy Acids on Insoluble Polymer Supports, Bull. Chem. Soc. Japan, 47:160 165 (1974).14M. Calmes et al., "Polyacrylic Crosslinked Resins With Pendant Chirality As Auxiliary In Supported Asymmetric Synthesis," Tetrahedron Letters, Pergamon Journal, 27(36):4303-4306 (1986).15 *M. Calmes et al., Polyacrylic Crosslinked Resins With Pendant Chirality As Auxiliary In Supported Asymmetric Synthesis, Tetrahedron Letters, Pergamon Journal, 27(36):4303 4306 (1986).16McArthur et al., "Polymer Supported Enantioselective Reactions.II. α-Methylation of Cyclohexanone", Can. J. Chem., 60:1836-1841.17McArthur et al., "Polymer Supported Enantioselective Reactions.III. Protonation of Lithioenamine Derivatives of Racemic 2-Methylcyclohexanone," Can. J. Chem. 60:2984-45 (1982).18 *McArthur et al., Polymer Supported Enantioselective Reactions.II. Methylation of Cyclohexanone , Can. J. Chem., 60:1836 1841.19 *McArthur et al., Polymer Supported Enantioselective Reactions.III. Protonation of Lithioenamine Derivatives of Racemic 2 Methylcyclohexanone, Can. J. Chem. 60:2984 45 (1982).20 *Organic Chemistry, Robert T. Morrison and Robert N. Boyd, Allyn and Bacon, Inc., Fifth Edition, 1987, pp. 131 132.21Peter Marfey, "Determination of d-Amino Acids.II.Use of a Bifunctional Reagent, 1,5-Difluoro-2,4-Dinitrobenzene, Carlsberg Res. Commun.", 49:591-596 (1984).22 *Peter Marfey, Determination of d Amino Acids.II.Use of a Bifunctional Reagent, 1,5 Difluoro 2,4 Dinitrobenzene, Carlsberg Res. Commun. , 49:591 596 (1984).23 *R. E. Dickerson and I. Geis, The Structure and Action of Proteins, p. 79: Harper & Row, New York, 1969.24 *V. P. Shibaev et al. (1979) J. Polym. Sci. Polym Chem Ed., 17, 1655 1670.25V. P. Shibaev et al. (1979) J. Polym. Sci. Polym Chem Ed., 17, 1655-1670.* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS5391634 *Jan 21, 1994Feb 21, 1995The Dow Chemical CompanyOptically-active, amphiphilic, water-soluble free-radical addition copolymers and their use in the resolution of racemic mixturesUS5435919 *Nov 17, 1994Jul 25, 1995The Dow Chemical CompanyOptically-active, amhiphilic, water-soluble free-radical addition copolymers and their use in the resolution of racemic mixturesUS6713580Dec 6, 2001Mar 30, 2004Pharmacore, Inc.Quaternary amino acids on solid supportsUS6809207Jul 24, 2002Oct 26, 2004Pharmacore, Inc.Amino acid derivativesUS6930200Jun 26, 2003Aug 16, 2005Pharmacore, Inc.Multicomponent synthesis of amino acids and derivatives thereofUS20040038771 *Jun 20, 2003Feb 26, 2004Fox Gerald P.Epicyclic drive with unified planet assembliesWO2000043352A1 *Jan 21, 2000Jul 27, 2000Adnan M M MjalliA method for the synthesis of compounds of formula 1 and derivatives thereof* Cited by examinerClassifications U.S. Classification526/263, 562/401, 564/304, 562/554, 562/575, 526/304, 526/306, 564/303, 562/445, 526/315, 564/302, 562/553, 526/305, 526/312International ClassificationC08F246/00Cooperative ClassificationC08F246/00European ClassificationC08F246/00Legal EventsDateCodeEventDescriptionJun 27, 1997FPAYFee paymentYear of fee payment: 4Jun 27, 2001FPAYFee paymentYear of fee payment: 8Jun 21, 2005FPAYFee paymentYear of fee payment: 12RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services

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Apple MacBook Air 13-inch Laptop (Intel Dual Core i5 1.3 GHz, 4 GB RAM, 128 GB HDD, Intel HD Graphic 5000, OS X) - Silver - 2013 - MD760B/A - UK Keyboard: Amazon.co.uk: Computers & Accessories
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Comment: Tiny pin-head sized chip to the right palm rest and to the front right corner of the lid. Maybe an odd feint mark to the lid but generally pristine.
Apple MacBook Air 13-inch Laptop (Intel Dual Core i5 1.3 GHz, 4 GB RAM, 128 GB HDD, Intel HD Graphic 5000, OS X) - Silver - 2013 - MD760B/A - UK Keyboard
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Apple MacBook Air MMGF2B/A 13.3-Inch Laptop (Silver) - (Intel Core i5 1.6 GHz, 8 GB RAM, 128 GB SSD, Intel HD Graphics 6000, OS X El Capitan) - 2016 - UK Keyboard Apple MacBook Air 13-Inch (Intel Core i5 1.6 GHz, 4 GB RAM, 256 GB SSD, OS X Yosemite) - MJVG2B/A - UK Keyboard Apple MacBook Pro 13-inch Laptop (Intel Dual Core i5 2.5 GHz, 4 GB RAM, 500 GB HDD, HD Graphics 4000, OS X Yosemite) - Silver - 2012 Apple 11 inch MacBook Air (Dual-Core i5,1.6GHz,4GB,128GB Flash,HD Graphics) Apple MacBook Pro with Retina Display 13-inch Laptop (Intel Core i5 2.7 GHz, 8 GB RAM, 128 GB, Intel Iris, macOS) - Silver - 2015 - MF839B/A - UK Keyboard Add to Basket
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Style: 128GB HDD
Product Dimensions33.9 x 42.7 x 12.4 cm
Item model numberMD760B/A
SeriesMacbook AIR MD760B/A
Maximum Display Resolution900p
Processor Speed1.3 GHz
Graphics Card DescriptionIntel HD
Graphics RAM TypeSDRAM
Wireless Type802.11A, 802.11 A/C, 802.11B, 802.11G, 802.11n
Hardware PlatformMac
Average Battery Life (in hours)12 hours
Lithium Battery Energy Content35 watt_hours
Lithium Battery Weight2 Grams
ASINB00DCR3SP2
13,458 in Computers & Accessories (See top 100)
Date First Available10 Jun. 2013
Style Name:128GB HDD
Apple MD760B/A 13.3 inch MacBook Air Dual Core i5 , 1.3GHz, Turbo Boost 4GB Ram ,128HDD, Intel HD Graphic 5000 2 x USB 3.0 Mac OS X and iLife Box Contains
MacBook Air 45W MagSafe 2 power Adapter, AC wall plug and power lead Printed and electronic documentation
4.0 out of 5 starsThis is a superceded model.
on 10 May 2014Style: 256GB HDD
Apple updated the Macbook Air models on the 29th April 2014. This release supersedes the 2013 - 1.3ghz model advertised here. The new 2014 model received a new 1.4ghz processor and a reduction in the RRP. The previous model had a RRP of £1,129. This RRP has now been reduced to £999 for the new 2014 model. Therefore the RRP on the previous 2013 model (advertised here) has also dropped to £799. This means that the current information for this model is now incorrect. Amazon has been informed of this last week but as of yet has not changed the details. The 2013 models are currently being sold for more than the RRP for those models. The 256GB version of this model is being sold elsewhere online from £699 - £799, and so is overpriced on Amazon.Further to this, the product information for the 256GB model claims it has a 512GB drive. This is incorrect, but as of yet has Amazon has not corrected the mistake. It is also not clearly advertised that this model is a US version with a USA keyboard and adaptor. This should clearly be advertised. The false RRP, product details, and lack of clearly stating it is a US model are all a breach of trading standards and should be updated ASAP.
on 4 Jun. 2014Style: 256GB HDD
I bought this as a birthday present for my son, and he is delighted with it. It has all the functions he requires and it has fast response.l was very pleased with the delivery as well. It arrived within a few days.
on 18 May 2017Style: 256GB HDD
Nice product. Recommended!
5.0 out of 5 starsThe best lap top for every day use
on 23 Sept. 2014Style: 128GB HDD
The best lap top for every day use.
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on 27 Jan. 2015Style: 128GB HDD
Amazing value for money. Was looking to buy a new laptop for work (old Sony Vaio was tantamount to a weapon - although I would struggle to heave it up on to my shoulder). This does everything it should for a fraction of the UK price. Yes its missing the £ key (but shift and 3 gets that result - as I type this from the laptop). The UK power cables work fine and the size of the scree works for me. Big enough to fit on one's lap and watch a film (Samsung external DVD drive), or a USB; or laptop's hard drive. Have purchased some non-Apple thunder cables for HDMI and serial ports (two separate ones) and these both work perfectly.
on 6 Aug. 2013Style: 256GB HDD
Easy choice if you need something that works well and has great battery life. The price is well ... high compared to windows laptops, but the difference can be easily felt just in a few days of use.Worth it.
5.0 out of 5 starsBrilliant machine persuaded me to leave windows!
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on 29 Oct. 2013Style: 256GB HDD
I have always been a huge supporter of 'Windows' and very anti Apple. However, the combination of the truly appalling windows 8 and a really dire Lenovo Twist (which really did not work) forced me to consider alternatives.The Macbook Air is a dream to use and seems to me to be everything that the Lenovo and windows 8 could have been but were not!! I regularly get 10 hours plus from one charge, a complete revelation, the use of multiple screens and a stunning trackpad make it a pleasure to use and it really does work all the time. The combination of brilliant hardware and stunning software make it worth 'saving up for' although actually it was not a lot more than the brick Lenovo call a computer!
Forbsie77
on 27 Oct. 2014Style: 256GB HDD
I shopped around for months looking for the best portable lap top and trying to get the best price. The conclusion of that research was to buy this 13 inch Mac book air.It's brand new and factory sealed. Great price and the only trade off is that the # key is actually the £ sign.I love it so much. I think it might be the best thing I've ever bought.I'm used to watching HD channels on TV and I find the display crisp and clear. The sound is great as well.It's superfast at starting up and so light that I hardly notice that I'm carrying it every day in my handbag to work and back.I would definitely recommend this. I bought the 256gb so it cost around £770. I had to purchase office for Mac as well from Microsoft but found that the Mac version is extremely user friendly in comparison to some of the newer windows versions of word.Can't complain at all about anything.
5.0 out of 5 starsBought this 2 years ago and it still works like it did the first day i...
Bought this 2 years ago and it still works like it did the first day i bought it!I like the look of the macbook, it's light, not too big and easy for when you're travveling!
Published 7 months ago by Ayoub
right now on this review i am writing with this macbook air. It did have an american keyboard but who cares.
Published 13 months ago by jun
5.0 out of 5 starsApple MacBook Air laptop
Excellent piece of equipment ! Would highly recommend , purchased for my daughters Christmas present! She has wanted one for some time now, saved £150.
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5.0 out of 5 starsthe beast!
I very pleased with the purchase! This machine meets all my needs exceptionally well.
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5.0 out of 5 starsVery, very good!!!
Love my Apple!! And the discount because the keyboard has the dollar sign instead of the pound one was very welcome! After years of MS Office, I am not going back!
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Great laptop wonderful design and battery life
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Everything you expect from a Hampton -- clean... - Review of Hampton Inn Jackson Clinton - TripAdvisor
“Pool was outdoor and closed because of season”
“Hampton Inn provides complimentary hot breakfast...”
“Asked for a room on first floor and recieved it”
Everything you expect from a Hampton -- clean... - Review of Hampton Inn Jackson Clinton
See the most recent reviews DomeRanger
Everything you expect from a Hampton -- clean, comfortable room and bed; excellent breakfast, including the waffle iron. My key wasn't working when I got there, but they got it resolved fairly quickly and courteously.
Thank DomeRanger Report Ask DomeRanger about Hampton Inn Jackson Clinton
English first Italian first Any Tray D
Very easy to find, right off the interstate. I booked ahead and after hearing lots of people talking about how nice Hampton Inns are I decided to give it a shot. The hotel to me was average, I could not understand what was suppose to be so good about Hampton Inns. For the price I was paying I was expected to be wow'ed. It's clean and neat, but had lots of wear and tear.
Helpful? Thank Tray D Report Ask Tray D about Hampton Inn Jackson Clinton
Level Contributor 7 reviews 3 helpful votes “Nice clean hotel”
Nice Hampton, indoor rooms. Appears like a new hotel from the outside but must have been remodeled because he the bath was older and not in the same condition as the rest of the hotel. Very clean though, nothing wrong with the bath. The service was as you come to expect at a Hampton, very prompt and professional. Nice stay.
Helpful? Thank Jenny B Report Ask Jenny B about Hampton Inn Jackson Clinton
Good location right off of the exit but a little difficult to enter the hotel from highway due to only one entrance and from the center lane. Close to dining options. Hotel has great customer service at the front desk to the houseclean crew. Hotel is clean. Rooms are clean as well. I booked a suite that has a seperate living area with tv and bar. Room was located close to the elevators but I could not hear any traffic inside my room. There is a manager's reception in the evenings. Breakfast is hot and very good layout so that you are able to get yourself served quickly and out to whatever your goals are for the day. Exersice room available for those interested. I would stay here again if in this area again.
Room Tip: Rooms on the back side of hotel are quieter and not facing traffic.
Helpful? Thank Glenda C Report Ask Glenda C about Hampton Inn Jackson Clinton
45 helpful votes “Just an OK Hampton”
This is not the best Hampton Inn I've stayed at. Just adequate -- very comfy bed, but you could hear water running in the adjoining rooms. I think this is an older hotel. It was clean, but definitely could use an updating. Breakfast was excellent. Very difficult to enter from the highway --there is just one entrance -- and I missed it two times! Staff was very courteous. I would stay here again.
Helpful? Thank Walklady Report Ask Walklady about Hampton Inn Jackson Clinton
68 helpful votes “A break from driving”
TripAdvisor is proud to partner with Booking.com, Hilton Hotels Direct, Hotels.com, Expedia, Orbitz, Travelocity, Hotwire, Priceline, Cancelon, Cheap Tickets, Hotel.de, getaroom.com and HotelQuickly so you can book your Hampton Inn Jackson Clinton reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.

value: This website is an American online travel company that operates a website and mobile app with user-generated content and a comparison shopping website.


text:
Patent US4682810 - Wheeled stretcher in which the plane on which the patient lies is adaptable ... - Google Patents
This invention relates to a wheeled stretcher in which the plane on which the patient lies is adaptable in height, comprising a frame on which is fixed a top element and which rests on the ground via a support provided with wheels, wherein each leg of the support is connected to the frame by a connecting...http://www.google.com/patents/US4682810?utm_source=gb-gplus-sharePatent US4682810 - Wheeled stretcher in which the plane on which the patient lies is adaptable in height
Publication number US4682810 A
Application number US 06/787,907
Also published as DE3571758D1, EP0179712A1, EP0179712B1
Publication number 06787907, 787907, US 4682810 A, US 4682810A, US-A-4682810, US4682810 A, US4682810A
Inventors Michel Zarka
Original Assignee Contact Securite - Societe d'Exploitation
US 4682810 A
US4052097 * Apr 19, 1976 Oct 4, 1977 Burt Weil Cart for high deck ambulances
DE2544931A1 * Oct 7, 1975 Apr 22, 1976 Searle & Co Fahrbare tragbahre
FR2105938A5 * Title not available
FR2439583A1 * Title not available
U.S. Classification 296/20, 5/625, 280/640, 5/280
Cooperative Classification A61G1/0262, A61G1/0231, A61G1/0212, A61G1/0293, A61G1/0562
Owner name: CONTACT SECURITE-SOCIETE D EXPLOITATION- 22 BIS, B
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:ZARKA, MICHEL;REEL/FRAME:004469/0298


text:
Robert Herring (1909-1985) - Find A Grave Memorial
28 Mar 1985 (aged 75)
168820062 · View Source
Andrew Jackson Herring
Samuel Elbert Herring
Faith Curtis Herring Bryant
Baby Boy Herring
Cecil Jackson Herring
Find A Grave Memorial 168820062
Find A Grave, database and images (https://www.findagrave.com : accessed ), memorial page for Robert Herring (19 Jul 1909–28 Mar 1985), Find A Grave Memorial no. 168820062, citing Overton City Cemetery, Overton, Rusk County, Texas, USA ; Maintained by Deb Vondrasek (contributor 48295140) .
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Once Upon The Prairie (The Brides Of Courage, Kansas, Book 1) by Lenny Davis by Lenny Davis - Read Online
Once Upon The Prairie (The Brides Of Courage, Kansas, Book 1)
Once Upon The Prairie - A Western Romance Novella (The Brides Of Courage, Kansas, Book 1)
Married to the meanest rancher in Kansas, unhappy Mina Morlock lives in a golden cage, as her husband is also the richest man in the state.
Her husband's foolishness puts him in awful opposition to the charismatic cowboy Jesse Bartleby and his men.
Drawn to Jesse, but married to Neville Morlock, Mina does the right thing — and finds a happily-ever-after that she had not dared to dream of.
Enjoy this clean sixty-page Western romance by Lenny Davis.
The Brides of Courage, Kansas, Series of historical Western Mail Order Bride Romances:
"Once Upon the Prairie," Book 1
"She Came One Winter," Book 2
"A Bride In Spring," Book 3
"Heart of Summer," Book 4
Publisher: Sharaya LeeReleased: May 1, 1998ISBN: 9781310843945Format: book
Once Upon The Prairie (The Brides Of Courage, Kansas, Book 1) - Lenny Davis
September 1867:
A sweet melody wafted through the darkness.
Whenever Jesse Bartleby sang, the whole prairie fell silent. The cowboys around the campfire ceased to talk and even told their card-playing companions to tone it down, because they wanted to listen to his wonderful bass.
The longhorns lifted their heads, stared at him as he rode by, and chewed their cud in silence. Taking care of the first watch at night, Jesse sang the old songs that every cowboy knew. Those about life on the trail. And also those about the girls in Santa Fe and Dodge and Abilene and everywhere else, and a few self-made ones about his loved ones at home.
The stars above him shone like diamonds on black velvet.
He rode a wide circle around the herd. Since Jesse knew that the others enjoyed his singing, he gave it his all and sang loudly as long as he was in earshot. But once alone, he just hummed to himself and enjoyed the solitude. It was a quiet night. Even though it had been dark for an hour, the September heat was still present in the whispering grass.
A cloud darkened the moon just when Jesse arrived by a copse of trees with a prominent willow in the middle. He fell silent. In the stillness he heard a horse snort.
It wasn't his.
Jesse drew rein and his horse stopped. Unmoving, he sat still like a statue on his mount. Ears pricked, he listened intently, until he heard sniffles and then sobs. For a moment Jesse sat perplexed, pondering what to do. Generally speaking, other people's sobs and sniffles were none of his business. And most people didn't care to have anybody around when they wept. Should he say 'Halt, who's there?' Should he just ride on? That might be the smart thing to do. But if somebody had fallen and was now lying helplessly on the ground, he had a duty to help.
He heard the sniffles and sobs again.
They seem to be coming from a woman. Jesse wondered who she might be. They were a good mile away from the ranch house and it was dark. No woman in her right mind would venture out into the darkness by herself. Unless she was supremely distraught for some reason.
Jesse felt he had to help.
Without a sound he slipped off his horse. Holding the reins, he stared at the copse, wishing the cloud would finally get past the moon. He hardly saw a thing. Very gently, Jesse began to sing 'Oh Susanna.'
The sobs immediately stopped. Jesse heard somebody get up. That moment, the moon began to shine again. In its pale light he saw a woman in a riding habit stand under a wide-branched tree. Her gleaming white face was framed by long black curls. Tense, she stood erect, a horse whip in her hand.
Who's there? the woman said.
Jesse stopped singing. Her voice had a ring of authority about it. This was not a kitchen maid. I'm just a cowboy, ma'am. I don't mean no harm.
Don't come closer or I'll shoot you.
Jesse cracked half a grin. With that switch in your hand?
I haven't seen you before, the woman said, undeterred. Who are you?
Why, I'm the leader of Jesse Bartleby's men.
The woman looked at him quizzically. She cocked her head. That would mean you are Jesse Bartleby.
Jesse nodded. His silliness was meant to put her at ease. At your service, ma'am. All he could do was keep from staring at the woman in front of him. She was tall. Her black dress suited her very well. It shimmered and shone in the moonlight as if it were made of silk. Probably was. Its collar and cuffs were made of white lace. Jesse couldn't help but think she was a queen. A queen with a waist like a wasp's.
That means you're working for Neville Morlock.
Again Jesse nodded. In a week or so we hope to get paid and then we'll be on our way. He meant to talk to the woman about the reason for her crying. Telling her that he'd be out of the picture soon might open her up. If she cared to talk to him, he would take her secret with him and she wouldn't have to worry about having confided in a stranger.
Suddenly overcome, the woman's gaze fell to the ground. Her shoulders began to heave and she began to weep again. She wiped her tears away with the heel of her hand.
Jesse dropped the reins. Walking towards her, he fished around in his pocket for his handkerchief. Good thing it was clean. He'd washed it in the creek just this afternoon. Keeping a yard distance between them, he stretched out his hand with his handkerchief.
The woman pulled herself together. She breathed deeply, then her face rose and she looked Jesse into the eye.
The cowboys heart almost skipped a beat. Standing there, his arm still outstretched, handkerchief in hand, he found it difficult to quit staring at her. Jesse knew, of course, how impolite and even rude that was.
The woman hesitated for a moment, but then she took his kerchief. She dabbed her eyes with it.
Like a queen, Jesse kept thinking. Pardon my curiosity, ma'am. If you don't mind me asking, what's ailing you?
Nothing. Her gaze fell to the ground again. She bunched the handkerchief up in her hand.
She's tense again. Got to tread softly now. Usually his melodious voice and gentle manners immediately put people at ease when he was around them. This woman seemed different. Of course, he couldn't blame her for being apprehensive. After all, they were not part of a happy crowd that was milling about in front of the church house on Sunday after the service. It was night and they were alone on the prairie. All women but the most jaded would be apprehensive under these circumstances.
I'll skip to my lou in a week, ma'am. Your secret's safe with me. He could no more than offer his assistance.
Before he knew it, Jesse had reached out with his hand. He lifted her face up gently with two fingers. Their eyes briefly met. Jesse thought hers were stunning. They had a sheen like glowing coals.
But then something else attracted his attention. Standing so close to her, he spied fingerprints on her pale cheek.
Somebody slapped you! The cowboy felt anger well up in him. Who walloped you, ma'am? Was it a member of the Black Thirteen?
She jerked her head away. I told you, there's nothing wrong with me.
Just tell me his name, Jesse growled. Me and my men will pay him a visit. We'll make sure he'll never beat another woman the longest day he lives.
The lady turned her back to him and walked away a few steps. All Jesse could do was keep from stepping up behind her to put his hands on her shoulders. He wanted to reassure this woman that she was safe with him. And that if she'd confide in him, he and his men would right her wrongs. Until just a few years ago, Jesse had been a captain in the gray army. His men, cowboys now, had all been soldiers under his command once.

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text:
PREMIS OWL ontology now available - PREMIS: Preservation Metadata Maintenance Activity (Library of Congress)
PREMIS Home » PREMIS OWL ontology Official Web Site PREMIS OWL ontology 2.2 now available
The PREMIS Editorial Committee is pleased to announce the publication of a revised PREMIS OWL ontology based on the PREMIS Data Dictionary for Preservation Metadata version 2.2 [1], a digital preservation standard based on the OAIS reference model. An earlier version of the PREMIS OWL ontology [2] was made available in October 2011, sticking as closely as possible to the PREMIS Data Dictionary semantic unit definitions. Before that time the PREMIS Data Dictionary was only implemented as an XML schema, which remains ideal for creating, validating and storing the preservation metadata of a particular digital asset. This revision of the ontology introduces several changes from the previous draft version:
The PREMIS ontology is now officially within the loc.gov namespace; it's namespace is now: http://www.loc.gov/premis/rdf/v1#
It integrates changes from PREMIS version 2.2, especially the enhanced model for the Rights entity
It makes use of 24 value vocabularies - each reflecting a suggested or controlled list of values from the PREMIS Data Dictionary - that have been added to id.loc.gov [3], covering a much wider range of PREMIS semantic units than before (21 value vocabularies are new additions to id.loc.gov as of this announcement; they may all be reviewed at http://id.loc.gov/preservationdescriptions/.
It makes minor corrections and implements a more Linked Data approach, rather than attempting to provide properties and classes for every semantic unit in the Data Dictionary. For instance, Extensions were dropped, since combining external vocabularies are built-in capabilities of Linked Data
Fuller documentation of the classes and properties
This OWL ontology allows one to provide a Linked Data-friendly, PREMIS-endorsed serialization of the PREMIS Data Dictionary version 2.2. This can be leveraged to have a Linked Data-friendly data management function for a preservation repository, allowing for SPARQL querying. It integrates PREMIS information with other Linked Data compliant datasets, especially format registries, which are now referenced from the PREMIS ontology (for instance, the Unified Digital Format Registry [4] and PRONOM [5]). Thus information can be more easily interconnected, especially between different repository databases. The OWL design of PREMIS should NOT be considered as a replacement for the XML Schema: the two of them should rather be considered complementary. Work to align the PREMIS ontology with the PROV ontology [6] is being considered. The ontology is public and open for review and is available at: http://www.loc.gov/premis/rdf/v1#. Please send comments by July 30, 2013 to the PREMIS Implementers� Group list ([email protected]).
[1] http://www.loc.gov/standards/premis/v2/premis-2-2.pdf
[2] http://multimedialab.elis.ugent.be/users/samcoppe/Ontologies/premis/index.html
[3] http://id.loc.gov/vocabulary/preservation.html
[4] http://udfr.org/onto/onto.rdf
[5] http://www.nationalarchives.gov.uk/PRONOM/Default.aspx
[6] http://www.w3.org/TR/prov-o/
PREMIS Home » PREMIS OWL ontology The

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text: Tavon Austin remains out702dNick WagonerA battle of defensive tackles and red zone production keys to Rams-Bengals16hNick WagonerRobert Quinn, Trumaine Johnson questionable against Bengals1dNick WagonerRams QB Case Keenum questionable; Nick Foles likely to start Sunday1dNick WagonerStedman Bailey still in stable condition as Austin, Britt don his jersey in tribute1dNick WagonerGetting Tavon Austin the ball must be Rams' priority2dNick WagonerRams running back Todd Gurley soars in Pro Bowl voting2dNick WagonerOn guard: Rams turn to Demetrius Rhaney, Cody Wichmann to handle interior OL spots2dNick WagonerSt. Louis Rams' Black Friday shopping list includes four-leaf clover2dNick WagonerJeff Fisher: NFL still examining concussion protocols3dNick WagonerExamining emergency quarterbacks and Rams' Johnny Hekker3dNick WagonerFrom Division II to a new locker location, Matt Longacre finding his place with Rams3dNick Wagonerplay0:47What's trending in the NFL: Stedman Bailey recovering from being shot in head3dESPN.com staffplay0:57Case Keenum (concussion) practices on limited basis Wednesday3dNick Wagonerplay0:47Rams practice with hopeful outlooks on Bailey3dNick WagonerTavon Austin remains out12/26/20130 SharesEmailcommentNick Wagoner, ESPN Staff Writer Close Covered Rams for nine years for stlouisrams.com

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text:
Top 10 Serengeti National Park Hotels in Tanzania $191 | Cheap Hotels on Expedia
Serengeti National Park HotelsSerengeti National Park HotelsPlease correct the errors belowDestinationCheck-inCheck-outRooms123456789+Adults (18+)1234567891011121314Children (0-17)0123456Child 1: Age <11234567891011121314151617Child 2: Age <11234567891011121314151617Child 3: Age <11234567891011121314151617Child 4: Age <11234567891011121314151617Child 5: Age <11234567891011121314151617Child 6: Age <11234567891011121314151617Room 1Adults (18+)1234567891011121314Children (0-17)0123456Child 1: Age <11234567891011121314151617Child 2: Age <11234567891011121314151617Child 3: Age <11234567891011121314151617Child 4: Age <11234567891011121314151617Child 5: Age <11234567891011121314151617Child 6: Age <11234567891011121314151617Room 2Adults (18+)1234567891011121314Children (0-17)0123456Child 1: Age <11234567891011121314151617Child 2: Age <11234567891011121314151617Child 3: Age <11234567891011121314151617Child 4: Age <11234567891011121314151617Child 5: Age <11234567891011121314151617Child 6: Age <11234567891011121314151617Room 3Adults (18+)1234567891011121314Children (0-17)0123456Child 1: Age <11234567891011121314151617Child 2: Age <11234567891011121314151617Child 3: Age <11234567891011121314151617Child 4: Age <11234567891011121314151617Child 5: Age <11234567891011121314151617Child 6: Age <11234567891011121314151617Room 4Adults (18+)1234567891011121314Children (0-17)0123456Child 1: Age <11234567891011121314151617Child 2: Age <11234567891011121314151617Child 3: Age <11234567891011121314151617Child 4: Age <11234567891011121314151617Child 5: Age <11234567891011121314151617Child 6: Age <11234567891011121314151617Room 5Adults (18+)1234567891011121314Children (0-17)0123456Child 1: Age <11234567891011121314151617Child 2: Age <11234567891011121314151617Child 3: Age <11234567891011121314151617Child 4: Age <11234567891011121314151617Child 5: Age <11234567891011121314151617Child 6: Age <11234567891011121314151617Room 6Adults (18+)1234567891011121314Children (0-17)0123456Child 1: Age <11234567891011121314151617Child 2: Age <11234567891011121314151617Child 3: Age <11234567891011121314151617Child 4: Age <11234567891011121314151617Child 5: Age <11234567891011121314151617Child 6: Age <11234567891011121314151617Room 7Adults (18+)1234567891011121314Children (0-17)0123456Child 1: Age <11234567891011121314151617Child 2: Age <11234567891011121314151617Child 3: Age <11234567891011121314151617Child 4: Age <11234567891011121314151617Child 5: Age <11234567891011121314151617Child 6: Age <11234567891011121314151617Room 8Adults (18+)1234567891011121314Children (0-17)0123456Child 1: Age <11234567891011121314151617Child 2: Age <11234567891011121314151617Child 3: Age <11234567891011121314151617Child 4: Age <11234567891011121314151617Child 5: Age <11234567891011121314151617Child 6: Age <11234567891011121314151617Adults (18+)9101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384858687888990919293949596979899Children (0-17)0123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384858687888990919293949596979899Search Continue Planning Your Trip
Expedia.com • Hotels • Africa and Indian Ocean • Tanzania • Serengeti National Park Hotels
See all 24 Hotels in Serengeti National Park Four Seasons Safari Lodge Serengeti Four Seasons Safari Lodge Serengeti Central Serengeti, Serengeti National Park 5.0 out of 5.05 out of 5 (3 reviews) Set in Serengeti National Park, this family-friendly hotel is within 32 mi (52 km) of Frankfurt Zoological Society, Africa … Get Rates Serengeti Migration Camp Serengeti Migration Camp Northern Corridor, Serengeti National Park This tentalow is in Serengeti National Park. Get Rates Mbuzi Mawe Serena Camp Mbuzi Mawe Serena Camp Central Serengeti, Serengeti National Park 4.0 out of 5.04.6 out of 5 (7 reviews) Situated in a national park, this hotel is within 32 mi (52 km) of Frankfurt Zoological Society, Africa Regional Office, … Get Rates Grumeti Migration Camp Grumeti Migration Camp Grumeti Wildlife Reserve, Serengeti National Park 4.0 out of 5.0 This tentalow is in Serengeti National Park. $225Singita Explore Singita Explore Grumeti Reserves, Serengeti National Park 63210 Get Rates Serengeti Acacia Central Camp Serengeti Acacia Central Camp Central Serengeti, Serengeti National Park 7337 3.5 out of 5.0 Situated in a national park, this tentalow is within a 15-minute walk of Seronera Information Centre and Frankfurt Zoological … Get Rates Serengeti Serena Safari Lodge Serengeti Serena Safari Lodge Serengeti reserve, Serengeti National Park 100 4.0 out of 5.0 Situated in Serengeti National Park, this guesthouse is within 1 mi (2 km) of Seronera Information Centre and Frankfurt … Get Rates Mawe Luxury Tented Camp Mawe Luxury Tented Camp Central Serengeti, Serengeti National Park 4.0 out of 5.0 Situated in a national park, this tentalow is in the same region as Serengeti Reserve Institute. Get Rates Mbalageti Serengeti Mbalageti Serengeti Western Corridor Serengeti, Serengeti National Park 3.5 out of 5.0 This lodge is situated in a national park. $191Singita Faru Faru Lodge Singita Faru Faru Lodge Mawalla Park, Serengeti National Park 00000 $5,578
See all 24 Hotels in Serengeti National Park Recent Reviews in Serengeti National Park
Expedia Verified Review 4 out of 5 The food was excellent and the chef was great . Took personal attention to prepare food according to taste . The hotel staff was top notch . However the tent was unbearable at night with the howling wind and above all no power between 2.00 p.m to 6.00 p.m is unacceptable . There should be more pedestal fans inside the rooms . A verified traveler stayed at Mbuzi Mawe Serena Camp Posted 8 months ago Hide content
Where to stay in Serengeti National Park Hotel Class 3 stars (7)4 stars (4)5 stars (3) Near an Airport Kilimanjaro Intl.ArushaSeronera AirstripMara Serena Near an Attraction Masai Mara Reserve Hotel Theme Adventure Sport Hotel (11)All-inclusive Hotel (5)Arcade Hotel (1)Bar Hotel (28)Boutique Hotel (3)Business Hotel (11)Conference Center Hotels (11)Family Hotel (18)Golf Hotel (1)Green/Sustainable (1)Hotel with Pool (17)Hotel with a Concierge (7)Hotel with wifi (20)Kid Friendly Hotels (18)Luxury Hotel (11)Pet-friendly Hotel (1)Romantic Hotel (1)Shopping Hotel (2)Spa Hotel (17)Wedding Hotels (7) Hotel Brand Four Seasons (1)Independent (13)Relais & Chateaux (2)Serengeti National Park Hotel GuideTravelers to Tanzania will find 2 hotels within a 0.1-mile drive of Serengeti National Park, but there are none in Serengeti National Park itself.The Kirawira Serena Camp, Tanzania, which is the nearest hotel, is 20 miles from downtown Serengeti National Park. Also, investigate the Mbuzi Mawe Serena Camp, located in Tanzania, which is 15 miles away.Serengeti National Park offers a limited range of no-frills hotels. You'll find the Mbuzi Mawe Serena Camp situated 15 miles from the heart of the town.The Four Seasons Safari Lodge Serengeti is 13 miles from downtown Serengeti National Park. Another alternative is the Mapito Tented Camp, which is 9 miles away.If you are flying into Serengeti National Park, Mwanza Airport is a convenient airport. It is 130 miles from downtown. Malaika Beach Resort by Royal Orchid Hotels is close to the airport. Read More More Cheap Hotels in Serengeti National Park Mapito Tented CampFour Seasons Serengeti LodgeMbali Mbali Lodges and Camps Soroi Serengeti LodgeSayari Camp - All InclusiveRobanda Safari CampSerengeti Serena Safari LodgeSee a list of all hotels in Serengeti National Park Hotels Near Serengeti National Park, Tanzania Masai Mara HotelsBariadi HotelsMugumu HotelsNyanungu HotelsOlolaimutiek HotelsTalek HotelsMara Simba HotelsLolgorien HotelsSinoni HotelsAitong HotelsKalamera HotelsSimiyu Region Hotels Cheap Hotels in Other Destinations Hotels in ZanzibarTravel to Serengeti National Park & ExploreExplore Serengeti National Park with Expedia's Travel Guides to find the best prices on flights, cars, vacation packages, and more!Flights to Serengeti National ParkCar Rentals in Serengeti National ParkSerengeti National Park Vacations
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Luna Paradise by the Sea Parking

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text: The Chez Piggy Cookbook: Recipes from the Celebrated Restaurant and Bakery by Rose Richardson, Zal Yanovsky, Victoria Newbury (Compiled by) - New, Rare & Used Books Online at Alibris Marketplace

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Old_Boy_ comments on Should Rowan Atkinson apologise for playing a sketch as the Archbishop of Canterbury?jump to contentmy subredditsannouncementsArtAskRedditaskscienceawwblogbookscreepydataisbeautifulDIYDocumentariesEarthPornexplainlikeimfiveFitnessfoodfunnyFuturologygadgetsgamingGetMotivatedgifshistoryIAmAInternetIsBeautifulJokesLifeProTipslistentothismildlyinterestingmoviesMusicnewsnosleepnottheonionOldSchoolCoolpersonalfinancephilosophyphotoshopbattlespicsscienceShowerthoughtsspacesportstelevisiontifutodayilearnedTwoXChromosomesUpliftingNewsvideosworldnewsWritingPromptsedit subscriptionsfront-all-random | nosleep-Documentaries-books-gaming-todayilearned-Fitness-worldnews-philosophy-space-DIY-television-gadgets-InternetIsBeautiful-explainlikeimfive-dataisbeautiful-funny-Music-Jokes-LifeProTips-AskReddit-EarthPorn-science-askscience-aww-news-personalfinance-Art-UpliftingNews-movies-mildlyinteresting-TwoXChromosomes-gifs-nottheonion-IAmA-GetMotivated-photoshopbattles-tifu-pics-WritingPrompts-videos-sports-Futurology-Showerthoughts-listentothis-creepy-OldSchoolCool-history-foodmore » unitedkingdomcommentsrelatedwant to join? login or register in seconds|Englishlimit my search to /r/unitedkingdomuse the following search parameters to narrow your results:subreddit:subredditfind submissions in "subreddit"author:usernamefind submissions by "username"site:example.comfind submissions from "example.com"url:textsearch for "text" in urlselftext:textsearch for "text" in self post contentsself:yes (or self:no)include (or exclude) self postsnsfw:yes (or nsfw:no)include (or exclude) results marked as NSFWe.g. subreddit:aww site:imgur.com dogsee the search faq for details.advanced search: by author, subreddit...this post was submitted on 22 Apr 201334 points (74% upvoted)shortlink: remember mereset passwordloginSubmit a new LinkSubmit a self postunitedkingdomsubscribeunsubscribe80,908 readers244 users here nowFor the United Kingdom of Great Britain (England, Scotland, Wales) and Northern Ireland; News, Politics, Economics, Society, Business, Culture and anything else UK related.
a community for 6 yearsmessage the moderatorsMODERATORSBritishEnglishPoliceUoC/SwindonSkuldborezGeordie in LondonOoerYorkshirebeard-maketh-the-manYorkshireAutoModeratorLow OrbitRaerthLondon Town333435Should Rowan Atkinson apologise for playing a sketch as the Archbishop of Canterbury? (self.unitedkingdom)submitted 1 year ago by mountainfail156 commentssharecancelsorry, this has been archived and can no longer be voted onloading...sorted by: bestbesttopnewhotcontroversialoldrandomyou are viewing a single comment's thread.view the rest of the comments →[+]Old_Boy_ 0 points1 point2 points 1 year ago (0 children)[–]Old_Boy_ 0 points1 point2 points 1 year agosorry, this has been archived and can no longer be voted onThis country losing our sense of humour and common sense?...... It's comedy a lot of people enjoyed it who cares.. No need to get into deep though about it. Comedy you laugh or you don't end of. permalinkaboutblogaboutteamsource codeadvertisetrabalhoshelpwikiFAQreddiquetterulescontact ustoolsmobilefirefox extensionchrome extensionbuttonswidget<3reddit goldstoreredditgiftsreddit.tvradio redditUse of this site constitutes acceptance of our User Agreement {Genitive} and Privacy Policy {Genitive}. © 2014 reddit inc. All rights reserved.REDDIT and the ALIEN Logo are registered trademarks of reddit inc.close this windowyou'll need to login or register to do thatcreate a new accountall it takes is a username and passwordprivacy philosophy
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RC Sailing Boat | eBay
RC Laser radio controlled sailing boat- used
Sail, boom, mast etc as per photo. Original boat, good condition, RC Unit, radio gear, frequency CH90. RC LASER FOR SALE. Location: Wandsworth, West London, SW18.
Time left: 2d 21h 28m
User ID omudie (Feedback score 30)
21009 Graupner RC Radio Control Large Sailing Boat GR-65 RG 65 Yacht RRP £287
Graupner Models. RRP: £287! The GR65 is a sail yacht based on the RG65 class. The kit was developed with the latest design techniques on a 3D CAD/CAM system. All components are made of vacuum-moulded ...
Graupner Micro Magic "Carbon Edition" RC Model Yacht Radio Control Sailing Boat
The boat is designed for a jib trimming servo, so that you can fine-tune the sail trim while the boat is running. Factory-made, pre-sewn sail suit of highly efficient grey, lightweight, water-repellen...
Graupner Micro Magic Racing RC Model Yacht Radio Control Sailing Boat
VINTAGE FIBREGLASS MODEL SAILING BOAT MOULD RC YACHT(LONDON)
COLLECTION ONLY DUE TO SIZE FROM LONDON SE9.
Keel and steering wheel. (Russian language). - The transmitter.
Channel: 4CH. - 65cm competition size. - Pre-assembled Sail. - Hull length: 650mm. - Hull width: 135mm. - 1X Rc Boat. - Easy handling and DIY. - Boat Battery: 4X AA battery (Not included).
Krick Dumas Boats Star Class Sailing Boat Rc Kit/ds1121
Krick Star class sailing boat RC Kit / ds1121. Manufacturer: DUMAS BOATS. A classic sailing boat RC model of the Star class. The original was built and designed in 1911. Marke DUMAS BOATS. RC Spare an...
Jamara Atlantique 2CH RTR Remote Control Sailing Boat 27 MHz RC
Security & Safety. Personal Safety. Hama Traveller Compact Travel Tripod 3D Pan & Tilt Head 43cm 16" Quality. Coffee Machine Cleaning. Button Batteries. Tools & Tool Kits. Your order SORRY, Personal c...
There are not many rc boats on the market that are as well priced as these but none at this price level that are as quick as these. The boat looks great and is fully built, ready to use out of the box...
NEW MODEL SALE PRICE RTR GENUINE UK SELLER FAST POSTAGE
Heng long great white atlantic yacht rc racing speedboat. Nerf Style Outdoor Dart Guns (4). RC Boat Spares (8). RC Helicopter Spares (31). RC Tank Spares (3). There are not many rc boats on the market...
7008 RC Boat 28"DOUBLE HORSE ATLANTIC SAIL YACHT FAST RC RADIO CONTROL RACE
This craft is perfect for pools, small ponds, rivers and lakes. This RC Racing Boat has 2 powerful spinning propellers. Professionally designed and manufactured PC twin-propeller which provides huge t...
28" SYMA DOUBLE HORSE ATLANTIC SAIL YACHT FAST RC RADIO CONTROL RACE BOAT 7007
CHEAP SALE PRICE -RTR - BRAND NEW - HUGE TOY MODEL GIFT
The high gloss polycarbonate plastic body gives the boat a great look and added durability. Nerf Style Outdoor Dart Guns (4). RC Boat Spares (8). Everything included in the box to get on the water and...
29" SYMA DOUBLE HORSE ATLANTIC SAIL YACHT FAST RC RADIO CONTROL RACE BOAT 7007
7007 Boat (100% assembled). This craft is perfect for pools, small ponds, rivers and lakes. This RC Racing Boat has 2 powerful spinning propellers. Professionally designed and manufactured PC twin-pro...
600 mm x 200 mm by Lulham-Robinson Sails. also Ideal for corner patches on model boat sails. Ideal spares to carry in case a temporary or even permanent repair is needed to a jib, mainsail, or even a ...
radio controlled yacht sail set Binary joysway rc sailing boat rc universal
Sail size's are. 50x14cm large sail. 34x13cm small sail.
radio controlled yacht rigging joysway rc sailing boat universal sail mast 3mt
Rc Joysway Sailing Boat Binary Rtr 2,4ghz Yacht Catamaran Ship New
Marke Joysway. RC race sailing yacht BINARY. With the binary you get a high quality and very nice RC sailing yacht for the Leisure and recreational sailor. RC sailing yacht black red colour. The fusel...
21009 Graupner RC Radio Control Sailing Boat GR-65 RG 65 Yacht - Combo Package
Graupner Models. The GR65 is a sail yacht based on the RG65 class. - Sailing Boat GR 65, Almost Ready to Run (ARTR). Set contents: vacuum-moulded ABS parts for hull, deck, glass-fibre-reinforced plast...
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