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Redshirting OT Banner gets trip home - USC Trojans- ESPN
Redshirting OT Banner gets trip home1326dPedro MouraClay Helton knows USC needs more than just talent3dKevin GemmellProjecting the Pac-12's 3,000-yard passers4dKevin GemmellNo Pac-12 coach faces higher expectations than Mark Helfrich4dTravis HaneyProjecting the Pac-12's 1,000-yard receivers5dKevin GemmellClay Helton reveals his least favorite word in the English dictionary5dESPN.comThe heat is on: Ten games with the highest stakes in 20165dChris Low and Adam RittenbergThe top storyline for each Pac-12 team from now until kickoff6dTed MillerCollege football roundtable: Toughest Week 1 challenge6dESPN.com staffIt's 100 days till college football's binge-worthy first weekend6dIvan MaiselProjecting the Pac-12's 1,000-yard rushers7dKevin GemmellSights and sounds: The Opening Oakland7dErik McKinneyUSC coach Clay Helton breaks down Adoree' Jackson's snaps10dChantel JenningsWhy the College Football Playoff is the best thing to happen to Week 16dHeather DinichRedshirting OT Banner gets trip homeEmailcommentOct 12, 2012Pedro MouraEmailprintcommentLOS ANGELES -- USC Trojans freshman offensive lineman Zach Banner is redshirting this season, so he has been left at home for each of the Trojans' three trips this year.But coach Lane Kiffin is throwing him a bone this week and putting Banner on the travel squad for the team's game against Washington. Banner grew up in Tacoma, Wash., 30 miles from Seattle, where the game will be played, and was raised a Huskies fan.Banner was elated to find out he'd be accompanying the team, even though he won't be playing unless something drastic happens."If I was gonna pick any trip, it'd be this one," he said this week.The mammoth 6-foot-9, 335-pounder expects about 30 family members to attend and anticipated he'll be giving out a "a lot of love pats and I-miss-you's" on the field afterward.Teams are allowed to take 70 players on conference road trips. Kiffin said NCAA-mandated scholarship limitations and normal injuries have left the Trojans with less than 70 available players who they could count on in a game."We're not at that point," Kiffin said. "So we take some guys that never play and so that's the good thing about the sanctions. ... Zach gets to go on a trip home and go up there."Hopefully we won't be doing that for many years."Banner, the son of former NFL lineman Lincoln Kennedy, said he was stressing to himself that it was a business trip, regardless of the game's location. The fact that he went to several Huskies home games as recently as last season doesn't matter anymore, he said."One thing that's cool about it is Coach Kiff is giving me the opportunity not only to go home and see the family, something I'm not able to do because I'm not from around here, but he's also giving me the experience of what it's like to travel," Banner said this week. "Next year, for my real freshman year, I'm gonna know what it's like to travel and not have it phase me."His decision to attend USC over Washington and Oklahoma was a big deal in the Northwest in January. He said his "real friends" supported the decision whole-heartedly."They knew I wanted to be different," Banner said. "Usually everyone from back home stays home, but I wanted to be different. I wanted to see how my road could change on a different path."Banner is one of two Trojans from Washington. Walk-on kicker Alex Wood went to high school on Mercer Island. Fifty Huskies went to high school in California.The day after his high school graduation in June, Banner moved to Los Angeles. He hasn't been back since, and he may or may not have the opportunity to return home during the Trojans' brief holiday break in December because of basketball.So this could be his only contact with home for a while. And he's learned to appreciate Los Angeles and USC, but he's not afraid to say he misses the Seattle area."It's not gonna be able to replace home, ever," Banner said of L.A. "But it is gonna be able to substitute for it."

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Patent US6016335 - Telephone registration system for schools - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe interactive student registration system uses a computer system having a telephone interface providing a multiplicity of incoming telephone lines, a memory, a voice synthesizer output and a data connection to a host data processor of the institution. The host data processor provides a series of information...http://www.google.com/patents/US6016335?utm_source=gb-gplus-sharePatent US6016335 - Telephone registration system for schoolsAdvanced Patent SearchPublication numberUS6016335 APublication typeGrantApplication numberUS 08/846,968Publication dateJan 18, 2000Filing dateApr 30, 1997Priority dateMar 13, 1992Fee statusLapsedPublication number08846968, 846968, US 6016335 A, US 6016335A, US-A-6016335, US6016335 A, US6016335AInventorsAlex B. Lacy, Justin J. GreenOriginal AssigneeLacy; Alex B., Green; Justin J.Export CitationBiBTeX, EndNote, RefManPatent Citations (4), Non-Patent Citations (11), Referenced by (6), Classifications (17), Legal Events (3) External Links: USPTO, USPTO Assignment, EspacenetTelephone registration system for schools
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4255619 *Sep 5, 1979Mar 10, 1981Keihin Electric Express Railway Co., Ltd.Telephone reservation-processing systemUS4845739 *May 16, 1988Jul 4, 1989Fdr Interactive TechnologiesTelephonic-interface statistical analysis systemUS5016270 *Apr 3, 1989May 14, 1991First Data Resources Inc.Expanded telephone data organization systemUS5113430 *Oct 1, 1990May 12, 1992United States Advanced Network, Inc.Enhanced wide area audio response network* Cited by examinerNon-Patent CitationsReference1 *9270 Voice Response Unit General Information Manual, IBM GU 10 3000 01, 1989, pp. 19 21.29270 Voice Response Unit General Information Manual, IBM GU 10-3000-01, 1989, pp. 19-21.3 *Applied Voice Technology Announces The Purchase of 1776, Oct. 10, 1989.4 *Class Registrar Host Efficient Programmer s Guide, Applied Voice Technology, 1991, pp. 22 26.5Class Registrar Host Efficient Programmer's Guide, Applied Voice Technology, 1991, pp. 22-26.6 *College s Voice Network Lets Students Sign Up By Telephone Communications News, Aug. 1990 p. 34.7College's Voice Network Lets Students Sign Up By Telephone Communications News, Aug. 1990 p. 34.8 *Computer Communication s Specialists, Inc., an IBM Value Added Remarketer, Announces Its New Touch Tone Audio Response System, Sep. 25, 1985.9Computer Communication's Specialists, Inc., an IBM Value Added Remarketer, Announces Its New Touch-Tone Audio Response System, Sep. 25, 1985.10Network World "Voice Response Simplifies Cal. State Class Registration" v8, n11, p. 27, Mar. 18, 1991.11 *Network World Voice Response Simplifies Cal. State Class Registration v8, n11, p. 27, Mar. 18, 1991.* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS7031997 *May 2, 2001Apr 18, 2006Hitachi, Ltd.Method and apparatus for connecting terminals in a remote consulting systemUS8224757 *Feb 3, 2004Jul 17, 2012Sap AgCurriculum management systemUS8660918Nov 13, 2001Feb 25, 2014Weber & Associates, Inc.Virtual financial aid officeWO2001055918A1 *Jan 31, 2001Aug 2, 2001Carew Hopkins BrianA system for delivering educational informationWO2002021379A1 *Sep 5, 2001Mar 14, 2002Ge Financial Assurance HoldingIntegrated on-line course registration scheduling participant transcript and administrative monitoring systemWO2008061230A2 *Nov 16, 2007May 22, 2008Univ CreightonMobile registration system* Cited by examinerClassifications U.S. Classification379/67.1, 705/28, 379/93.12, 705/26.1International ClassificationG06Q30/06, G06Q10/08, G06Q10/10, H04M3/493Cooperative ClassificationG06Q10/10, G06Q10/087, G06Q30/0601, H04M2203/355, H04M3/493European ClassificationG06Q10/10, G06Q10/087, G06Q30/0601, H04M3/493Legal EventsDateCodeEventDescriptionMar 16, 2004FPExpired due to failure to pay maintenance feeEffective date: 20040118Jan 20, 2004LAPSLapse for failure to pay maintenance feesAug 6, 2003REMIMaintenance fee reminder mailedRotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services

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Icon information for dan_b:
This page has been generated for: dan_b
The icon shown at left, a silver wrench, designates that this user, dan_b, is an administrator of the current project, Comprehensive Common Lisp Archive Net.

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View Bridal Hair Pins by EvieRoseBridal on Etsy
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Fireside Book of Favorite American Songs | eBay Skip to main contenteBayShop bycategoryEnter your search keywordAll Categories Advanced or register':' style="margin-right:3px">Hi, #USER#!'.replace(/#USER#/,a))+"")}catch(b){document.write("")}})();Hi, (Sign in to bid or buy)Daily DealsSellCustomer SupportMy eBayExpand My eBayNotifications
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Promoted item:1952 Fireside Book of Favorite American Songs Piano Sheet Music Vocals
1952 Fireside Book of Favorite American Songs Piano Sheet Music Vocals
1952 arranged for the piano music. I know a bit about a lot of things, but I do not have expertise in all areas! I am NOT a professional/antique dealer. I’m constantly posting a variety of items, both...
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Vintage 1952 Fireside Book of Favorite American Songs-Boni,Lloyd,Battaglia,Brook
Classic addition to your collection. Great illustrations throughout.
Vintage Fireside Book of Favorite American Songs Piano~1952~Boni~Lloyd~HC~
You are looking at a vintage "Fireside Books of Favorite American Songs" hardcover book for piano/singing. In good used condition. Has cover wearing from aging-no loose pages.
The Fireside Book of FAVORITE AMERICAN SONGS-Margaret Boni~Battle Hymn REPUBLIC
Includes favorites such as: Frankie and Johnnie; In the Old Summertime; Midnight Special; My Old Kentucky Home; Battle Hymn of the Republic; We Three Kings; Nearer My God to Thee; Little Brown Jug; Th...
The Fireside Book Of Favorite American Songs 1952 Any Spots you see on clothing is from the camera , i will not sell dirty clothes. Buy It Now items should be paid immediately after purchase.
FIRESIDE BOOK OF FAVORITE AMERICAN SONGS COPYRIGHT 1952 ILLUS AURELIUS BATTAGLIA
Vintage song book titled THE FIRESIDE BOOK OF FAVORITE AMERICAN SONGS. Illustrated by Aurelius Bataglia. Simon Schuster, New York. Copyright renewed 1952. Large book measures 8" x 11". Hardcover. 3d 0h 9m left
Fireside Book of Favorite American Songs Vintage 1952 Ballad Work Historic Music
Fireside Book of Favorite American Songs selected and edited by Margaret Boni arranged for the piano by Norman Lloyd illustrated by Aurelius Battaglia. 13d 5h 53m left
FIRESIDE BOOK OF FAVORITE AMERICAN SONGS- 1952- 120+ SONGS
1952 FIRESIDE BOOK OF FAVORITE AMERICAN SONGS Sheet Music HB/DJ
The fireside book of favorite american songs. Title: the fireside book of favorite american songs. 4d 6h 20m left
Fireside Book of Favorite American Songs 1952
Stick Figure Books presents ... Notes: New York: Simon and Schuster, 1952. First edition. Hardcover. 359 pp. Very good book, lacking jacket. Some rubbing on board edges exposing boards. 6d 1h 37m left
1952 Vtg FIRESIDE BOOK OF FAVORITE AMERICAN SONGS Music Illustrations
Total pages: 359 with illustrations. There is wear on the spine and covers as you can see. No missing pages that I could find. Some minor writing marks on a few of the pages. 11d 8h 10m left
Fireside Book of Favorite American Songs - Piano, Vocals, HC/DJ, 1952, Illus
Title: Fireside Book of Favorite American Songs. Publisher, Published Date: Simon&Schuster, 1952. Selected and Edited by Margaret Bradford Boni. Cover Type: Hardcover with Dust Jacket. 18d 6h 47m left
Fireside Book of Favorite American Songs by Margaret Bradford Boni (1952) HC/DJ
Simon Schuster - Oversized Hardcover, Dustjacket Shows Wear, Otherwise, Very Good Condition, Illustrated, 359 Pages, Light Soil on Top of Navy Page Ends, Arranged for the Piano by Norman Lloyd - A lav...
The Fireside Book of Favorite American Songs 1952 with Jacket
Simon Schuster 1952 with jacket. Book is in very good condition. Jacket has wear and tears.. Free!
1952 Fireside Book of Favorite American Songs From Canada
The Fireside Book of. Darling Nelly Gray. Copyright 1952 The Oxen Song. The Liberty Song. 8.5" x 11"/360 pages (heavy book) March of the Men of Harlech. Index of Titles.
Copyright in 1952. Forward by Carl Van Doren. This book contains songs from pre-1776 through the 1890's. The book is in poor shape. The binding is falling apart. Some of the pages are missing (139 thr...
Buy It Now Vintage 1952 Fireside Book Of Favorite American Songs Second Edition Dust Jacket
2nd Edition 1952 Fireside Book Of Favorite American Songs Piano Songbook. There is a lot of wear and tear on this book. Many Imperfections But Pages in Good Condition and Very Readable. 2d 18h 37m left
Fireside Book of Favorite American Songs illus. Aurelius Battaglia Piano 1952
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Fireside Book of Favorite American Songs! #BV
You are looking at a tight, clean, vintage hardcover copy of 'THE FIRESIDE BOOK OF FAVORITE AMERICAN SONGS" published by Simon and Schuster of New York, copyright 1952. This is a large format book mea...

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Lazarus Golschmidt (1871-1950) - Find A Grave Memorial
Lazarus Golschmidt
Death 18 Apr 1950
Memorial ID 6001316
Noted bibliophile who built a unique collection of Hebrew incunabula. Also the first single-handed translator of the Talmud into German.
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Find A Grave Memorial 6001316
Find A Grave, database and images (https://www.findagrave.com : accessed ), memorial page for Lazarus Golschmidt (12 Dec 1871–18 Apr 1950), Find A Grave Memorial no. 6001316, citing Willesden United Synagogue Cemetery, Willesden, London Borough of Brent, Greater London, England ; Maintained by David Conway (contributor 92) .
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Amazing Stories, March 1983 (Volume 56, No. 5) by George Scithers: TSR, Inc. 9781773483030 Paperback - AbeBooks.com
Home George Scithers Amazing Stories, March 1983 (Volume 56, No. 5)
Amazing Stories, March 1983 (Volume 56, No. 5)
ISBN 10: 177348303X / ISBN 13: 9781773483030
Synopsis: CONTENTS: ~ ~~ ~ Against Infinity (Part 1 of 2) [Gregory Benford]; SHORT STORIES: Continued Lunacy [Darrell Schweitzer]; Epitaph [Bill Pronzini]; Favor [J. Michael Matuszewicz]; I Lost My Love to The Space Shuttle Columbia [Damien Broderick]; Improbable Bestiary: The Troll [F. Gwynplaine MacIntyre]; In the Islands [Pat Murphy]; On the Rebound [Jack C. Haldeman II]; Sand Painting [Allen L. Wold]; The Syncopated Man [Sharon Webb]; ARTICLES: Interview: A Bertram Chandler [Darrell Schweitzer]; The Amazing Years [Cele Goldsmith Lalli]
Title: Amazing Stories, March 1983 (Volume 56, No. ...
1. Amazing Science Fiction Stories Combined with Fantastic Stories March 1983 Vol. 56 No. 5
Scithers, George H., ed
Published by Dragon Publishing, Lake Geneva, WI (1983)
ISBN 10: 177348303X ISBN 13: 9781773483030
Book Description Dragon Publishing, Lake Geneva, WI, 1983. Printed wrappers. First Edition. Pages are slightly age-toned. A near fine copy. Stories by Gregory Benford, Thomas Disch, Bill Pronzini and others. ; Octavo. Seller Inventory # 10552
2. Amazing Stories, March 1983 (Volume 56, No. 5)
Book Description TSR, Inc. PAPERBACK. Condition: Fair. 177348303X Please allow 4 - 14 business days for Standard shipping, within the US. Seller Inventory # POXM-177348303X

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Patent US2549363 - Filter - Google Patents
www.google.comhttp://www.google.com/patents/US2549363?utm_source=gb-gplus-sharePatent US2549363 - Filter
Publication number US2549363 A
Publication number US 2549363 A, US 2549363A, US-A-2549363, US2549363 A, US2549363A
Inventors Blickman Bernard I
US 2549363 A
Abril 17, 1951 B. I. BLICKMAN FILTER Filed Dec. 3, 1945 INVENTOR. BERNARD I. BLICKMAN lh'i'iiWh' i'iil Ill! ll w M m m M ma 9 Patented Apr. 1 7, 1951 UNlTED OFF ICE} Q I FILTER. Bernard. IiBiickman- NewYcrk. N; Y., assignor: to SJ; Blickman, Inci, Weehawken; .N-.J., acct. poration ofNew York V I Application December 3, 1945:; Serial No; 632;448
bodies the invention. the novelfeatures of which will be definedin claims.
Referring to the drawingstis' Figure .l" is andiagrammatic:elevation; partly in section, of an apparatus which is made according to and embodies the present invention.
Figure 2 is a plan view of overlapping portions of the material of which the straineris made.
Figure 3 is an edge view of the parts shown in Figure 2, the section being takenon the line 3-3 of the latter figures.
' Figure 4 is a plan view of the strainer element, a part of which is shown in a section taken on the line 4--4 of Figure 1.
l designates a casing which is closed at the top and bottom by plates II and I2. This casing V j may be made conveniently of cylindrical'form.
An upstanding annular flange -I3 is formed on the upper surface of the bottom plate l2.
The strainer element is designated generally by the reference numeral 30. It forms an important part of the invention and its construction will be particularly described hereinafter. It rests on the bottom plate I2 within its flange 13. 3| is a plate having an annular flange 32 at its rim closing the top of the filter element. The plate 3! is shown aflixed to the bottom plate by rods 33, 33.
40 is an inlet pipe provided with a control valve 4|. It is connected with the casing at aside thereof; 42 is a drain pipe connected with an opening through the bottom plate 12. It is provided with a control valve 43. 44 is a pipe which extends through'th-e bottom plate l2 within the flange l3 into communication with the interior of the strainer element 30. 45 is a valve in the pipe 44. Another pipe 46 controlled by a valve 41 is connected to the pipe 44 between its upper end and the valve 45.
The strainer element is made of comparatively thin flexible perforated sheet metal or other maare: designated-bythe numeral 35;. They arezprefzerably smallrcircularr orifices? relatively spaced-in the mannernshownr and: separated. by solid? porjuxtaposed. that: the, perforations. in. each: regisr terial, two layers of which areshown in Figs. 2,
3 and 4 designated by 34 and 31;. Theperforations in the upper layer 34 (as'seen in Fig. 3)
terj with: the solid portion-s; ofa'the; other; Thus,
there are;- overlapping solid; portions:- of: the sheet material betweensalli ofithe: perforations;
Thezfiitering element-3.0rmay bemadeiofa sin- 15 glesheetof perforated: materials wound; to; form aicylinder: of multiplezthickness'; two bieingrshown in-iFi i. 4;. The layerss may be:v spotr-weldedi. to..- getherxatiintervals; to. maintain: their perforations and solid portions in the desired relative positions just described. The cylinder thus formed is held preferably in a vertical position between the flange I3 of thebottom plate and the annular flange 32 of the plate 3|.
The fluid to be clarified is led through the pipe into the casing l0, preferably under pressure. It passes through the wall of the strainer element 30 and escapes through the pipe 4-4. During this operation the valves 43 and 4'! are closed.
In passing into thestrainer the fluid passes through the perforations 35 in the outer layer of the sheet material, between overlapping solid portions of the two layers and through the perforations 38 of the inner layer. This is indicated by dotted-line arrows in' Fig. 3. In doing this, any particlesof foreign matter which are in the fluid admitted to the casing 10 are arrested at the peripheries of the perforations 35 in the outer layer.
A convenient way of cleaning the filtering element is by a reverse flow of a fluid. This is accomplished by closing valves 4! and and opening valves 43 and 41. Air, water or other fluid is admitted through the pipes 46 and 44 to the inside of the filtering element and passes through the two layers thereof into the casing In in the reverse direction from that first described. This dislodges such particles as have been arrested at p and do occur to others, especially after benefltting from knowledge of such a disclosure as said sheet being constructed to form a plurality of equally spaced openings with intermediate solid portions disposed to position the solid portions of each layer permanently over the openings in the proximate layer, said strainer resting upon the bottom closure plate within its up-* standing flange, a third plate over the upper end of the strainer having adownwardly extending edge surrounding said upper end of the strainer, means for interconnecting said bottom closure plate and said third plate, and means for forcing liquid under pressure alternately from the shell into the strainer and from the strainer into the shell.
2. A filtering apparatus comprising a cylindrical shell, a bottom closure plate having an upstanding annular flange of less diameter than that of the shell and a top closure plate, a hollow cylindrical strainer having a wall formed of a single elongated piece of sheet material wound into a plurality of layers lying upon one another, said sheet being constructed to form a plurality of equally spaced circular openings with intermediate solid portions disposed to position the solid portions of each layer permanently over the openings in the proximate layer, said strainer resting upon the bottom closure plate within its upstanding flange, a third plate over the upper end of the strainer having a downwardly extending edge surrounding said upper end of the strainer, means for interconnecting said bottom closure plate and said third plate, a valved inlet conduit communicating with the part of the shell outside of the strainer, a Valveddrain conduit communicating with the part of the shell outside of the strainer, a pipe passing through the bottom closure plate into the strainer, said pipe having a valved discharge portion, and a valved inlet conduit communicating with said pipe between the discharge portion thereof and said bottom closure plate.
BERNARD I. BLICKMAN.
UNITED STATES PATENTS Number Name Date 632,570 Howard Sept. 5, 1899 744,060 Frye Nov. 17, 1903 772,389 Webb Oct. 18, 1904 810,250 Barth Jan. 16, 1906 1,201,268 Davis Oct. 17, 1916 1,456,095 Collins May 22, 1923 2,269,031 MacArthur Jan. 6, 1942 2,339,703 'Kamrath Jan. 18, 1944 2,354,481 Russell July 25, 1944 FOREIGN PATENTS 7 Number Country Date 324,034 Great Britain Jan. 13,1930
US632570 * May 24, 1899 Sep 5, 1899 Thomas Howard Filter.
US744060 * Mar 20, 1903 Nov 17, 1903 james Frye Sieve or strainer.
US772389 * Dec 12, 1903 Oct 18, 1904 Jean F Webb Ore drainage and leaching tank.
US810250 * Apr 17, 1905 Jan 16, 1906 Otto B Barth Sugar-machine.
US1201268 * Jan 2, 1915 Oct 17, 1916 Charles B Davis Mash-tun or the like.
US1456095 * May 3, 1920 May 22, 1923 Collins Francis E Pressure oil filter
US2269031 * Jul 1, 1939 Jan 6, 1942 William J Macarthur Tank bleeder valve
US2339703 * Dec 9, 1940 Jan 18, 1944 Gen Motors Corp Coiled paper filter
US2354481 * Oct 5, 1942 Jul 25, 1944 Luber Finer Inc Filter shell
US2895102 * Apr 5, 1957 Jul 14, 1959 Dow Chemical Co Determination of conductivity of liquids
US6959817 * May 22, 2002 Nov 1, 2005 Orion Power Holdings Cooling makeup water intake cartridge filter for industry
US9138665 * Jul 20, 2012 Sep 22, 2015 Xylem Water Solutions Zelienople Llc Filter media retainer assembly
US20030010704 * May 22, 2002 Jan 16, 2003 Claypoole George T. Cooling makeup water intake cartridge filter for industry
US20140021121 * Jul 20, 2012 Jan 23, 2014 Xylem Water Solutions Zelienople Llc Filter media retainer assembly
U.S. Classification 210/411, 210/422, 210/494.1, 210/488, 210/453
International Classification B01D29/33, B01D29/31


text:
Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. - PubMed - NCBI
1 selected item: 24929951
Nat Med. 2014 Jul;20(7):759-63. doi: 10.1038/nm.3579. Epub 2014 Jun 15.
Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis.
Perry RJ1, Zhang XM2, Zhang D3, Kumashiro N2, Camporez JP2, Cline GW2, Rothman DL4, Shulman GI5.
1] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [3] Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA.
1] Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut, USA.
1] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [3] Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA. [4] Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Leptin treatment reverses hyperglycemia in animal models of poorly controlled type 1 diabetes (T1D), spurring great interest in the possibility of treating patients with this hormone. The antidiabetic effect of leptin has been postulated to occur through suppression of glucagon production, suppression of glucagon responsiveness or both; however, there does not appear to be a direct effect of leptin on the pancreatic alpha cell. Thus, the mechanisms responsible for the antidiabetic effect of leptin remain poorly understood. We quantified liver-specific rates of hepatic gluconeogenesis and substrate oxidation in conjunction with rates of whole-body acetate, glycerol and fatty acid turnover in three rat models of poorly controlled diabetes, including a model of diabetic ketoacidosis. We show that the higher rates of hepatic gluconeogenesis in all these models could be attributed to hypoleptinemia-induced activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in higher rates of adipocyte lipolysis, hepatic conversion of glycerol to glucose through a substrate push mechanism and conversion of pyruvate to glucose through greater hepatic acetyl-CoA allosteric activation of pyruvate carboxylase flux. Notably, these effects could be dissociated from changes in plasma insulin and glucagon concentrations and hepatic gluconeogenic protein expression. All the altered systemic and hepatic metabolic fluxes could be mimicked by infusing rats with Intralipid or corticosterone and were corrected by leptin replacement. These data demonstrate a critical role for lipolysis and substrate delivery to the liver, secondary to hypoleptinemia and HPA axis activity, in promoting higher hepatic gluconeogenesis and hyperglycemia in poorly controlled diabetes.
Absence of leptin triggers type 1 diabetes. [Nat Med. 2014]
Diabetes: how does leptin decrease hyperglycaemia in T1DM and T2DM? [Nat Rev Endocrinol. 2014]
24929951
PMC4344321
10.1038/nm.3579
Leptin reverses hyperglycemia and excess gluconeogenesis from pyruvate and glycerol in streptozotocin-induced type 1 diabetic (T1D) rats. (a)–(d) Fasting plasma glucose, insulin, glucagon, and leptin concentrations. In panel (d), n=16 for all groups. (e) Hepatic gluconeogenesis from pyruvate (lower bars) and glycerol (upper bars). P-values over the bars represent comparisons of total gluconeogenic flux. Gluconeogenesis from both pyruvate and glycerol was increased (P<0.05 and P<0.0001, respectively) in T1D rats vs. controls, and decreased (P<0.001 and P<0.0001, respectively) in T1D-leptin treated vs. T1D rats. (f)–(h) Whole-body glycerol, fatty acid (palmitate), and acetate turnover. (i) Liver acetyl CoA concentration. (j) 12 p.m. plasma corticosterone concentrations. Data are mean ± S.E. If not otherwise specified, n=6–8 per group. *P<0.05, ***P<0.001, ****P<0.0001 vs. control; ##P<0.01, ###P<0.001, ####P<0.0001 vs. T1D; §§§P<0.001 vs. T1D-leptin 6 hr.
Mechanism for the Anti-Diabetic Effect of Leptin
Nat Med. ;20(7):759-763.
24 hr lipid infusion in 3-day high fat fed rats replicates the perturbations to fluxes seen in T1D and hyperinsulinemic-diabetic rats and implicates increased substrate supply in the excess gluconeogenesis of T1D. (a) Plasma glucose. (b) Hepatic gluconeogenesis from pyruvate (lower bars) and glycerol (upper bars). Gluconeogenesis from both pyruvate and glycerol was increased (P<0.001 and P<0.01, respectively) in lipid-infused rats. (c) TCA cycle flux from fatty acid oxidation (lower bars) and through PDH (upper bars). VTCA from fatty acid oxidation was increased and VTCA through PDH was decreased (P<0.05) in lipid-infused rats. (d), (e) Whole-body glycerol and fatty acid (palmitate) turnover. (f) Liver acetyl CoA concentration. In all panels, data are mean ± S.E. of n=6 per group. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.
Substrate (Intralipid/heparin) infusion blocks leptin’s effect to suppress hepatic gluconeogenesis in T1D rats. (a) Fasting plasma glucose. (b) Hepatic gluconeogenesis from pyruvate (lower bars) and glycerol (upper bars). Gluconeogenesis from both pyruvate and glycerol was increased (P<0.01 and P<0.001, respectively) in lipid-infused rats. (c) VTCA from fatty acid oxidation (lower bars) and through pyruvate dehydrogenase (upper bars). VTCA through PDH was increased (P<0.05) in lipid-infused rats. (d), (e) Whole-body glycerol and palmitic acid oxidation. (f) Liver acetyl CoA concentration. In all panels, data are mean ± S.E. of n=6 per group. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.
Matching plasma corticosterone in high fat fed-corticosterone infused rats to that of T1D animals drives excess lipolysis, gluconeogenesis, and hyperglycemia. (a) Fasting plasma glucose. (b) Hepatic gluconeogenesis from pyruvate (solid bars) and glycerol (dashed bars). Gluconeogenesis from glycerol was increased (P<0.01) in corticosterone-infused rats. (c) Fasting plasma insulin. (d) TCA cycle flux from fatty acid oxidation (solid bars) and through PDH (dashed bars). (e)–(g) Whole-body glycerol, fatty acid (palmitate) and acetate turnover. (h) Liver acetyl CoA concentration. In all panels, data are mean ± S.E.M., n=6 per group. *P<0.05, **P<0.01, ****P<0.0001.
Leptin/therapeutic use*
R24 DK-085638/DK/NIDDK NIH HHS/United States

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Don't stop believe me.
76,057 Members
Kawan ke kaseh ke. Pegi mam la belakeee. Napok sangat la selama ni mg berlakon je depan aku. Sikit pon xjeles mg bahagia ke mg sedih ke mg nages air mata daroh ke. Aku ade sebab aku kenapa aku kecewa ngn awok mg! Tapi sory la, aku nak jeles atas kebahagi...
bulatsayangsaya.blogspot.my
Post ni didedikasikan khas untuk NUR HATIN BINTI ABDUL RAHIM. Terima kasih atas segalanya sepanjang persahabatan kita. Terima kasih sebab sudi jadi telinga yang baik dengar semua masalah aku. Terima kasih sebab ada disisi aku disaat aku perlukan mg. Terima ...
Hmm aku silap.
Mg xtgok aku pon.
Aku yg perasan lebih.
Once again aku rendahkan ego aku.
Memudahkan lagi org pijak kepala aku.
Hurm, nk mengalah? Bukan aku wt salah pon.
Aku just sedih, kecewa, makan hati dgn sikap dia.
Dia tak pikir perasaan aku kan? Xpe lah.
Saya akan terus senyap.
Kenapa mg ego sgtttt!
Langsung xboh mengalah!
Erm, selamat pagi ke ape eh? Heee tak tahu nak cakap apa. Lamanya tak update blog, bersawang lah blog ni hahaha. Macam lah ade org kisah. Lama tak bukak blogger, banyak betul komen. Tapinya pasal nama dalam bahasa korea lah. Bukan pasal iiolss pon. Hahha, ...
bulatsayangsaya.blogspot.com
Happy birthday chingu!!!
Xsempat nk bg ni kt awak.
Anggap jelah antara kita xdok jodohhhhh
Lamanya tak update blog. Heeee, Nak cakap buzy takdelah buzy pon. Duk rumah makan tido makan tido je.Tak buat apa pon. Hahaha. Tapi selalu datang jenguk. Heeee. Especially statistics. Hamboiii korang ni, Rancak bebenor pasal nama dalam bahasa korea. Antara...

value: This website .


text: _.Ek=function(){this.R=[];this.H=[]};_.Sia=function(a){_.Hb(a.R)&&(a.R=a.H,a.R.reverse(),a.H=[])};_.Fk=function(a){_.Sia(a);return a.R.pop()};_.h=_.Ek.prototype;_.h.Ue=function(){return this.R.length+this.H.length};_.h.de=function(){return _.Hb(this.R)&&_.Hb(this.H)};_.h.clear=function(){this.R=[];this.H=[]};_.h.contains=function(a){return _.Gb(this.R,a)||_.Gb(this.H,a)};_.h.remove=function(a){var b=this.R;var c=(0,_.wb)(b,a);0<=c?(_.Jb(b,c),b=!0):b=!1;return b||_.Kb(this.H,a)}; _.h.he=function(){for(var a=[],b=this.R.length-1;0<=b;--b)a.push(this.R[b]);for(var c=this.H.length,b=0;bBay Strength - Google+Press question mark to see available shortcut keysHomeCollectionsJoin Google+Send FeedbackHelpRegionPrivacy Policy - Terms of Service - Maps Terms©2017 GoogleSearchSign inAboutSearchSign inBay Strength3 followers3 followersAboutBay Strength's postsLooks like you've reached the endLooks like you've reached the endUnable to load more. RetryWait while more posts are being loaded


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 Bed Breakfast and Cappuccino - НАЙ-НИСКИ ЦЕНИ от agoda.com
Street Livorno 1, Номентано, Рим, Италия, 00162 - Покажи на картата
"A super pleasant experience! Nice staff, nice room, and brea..."
В близост Номентано Номентано Северен Рим Южен Рим
Метростанция Sant'Agnese - Annibaliano
Построен през 2008, Bed Breakfast and Cappuccino е важно допълнение към Рим и разумен избор за пътуващи. Вълнуващият център на града е само на 2.0 Km оттук. С удобното си местоположение хотелът предлага лесен достъп до всички градски забележителности, които задължително трябва да се видят.
Предлагайки висококачествени услуги и широка гама от удобства, Bed Breakfast and Cappuccino Ви осигурява възможно най-комфортния престой. Хотелът е оборудван със съоръжения като безплатен WiFi достъп във всички стаи, съхраняване на багаж, Wi-Fi връзка в общите части, летищен трансфер, семейна стая.
Bed Breakfast and Cappuccino разполага с 4 стаи, които са обзаведени с вкус. Много от тях предлагат удобства като телевизор с плосък екран, безжичен интернет достъп (безплатен), стаи за непушачи, климатик, отопление. Освен това в хотела можете да се възползвате от множество предложения за приятно прекарване на свободното време. Bed Breakfast and Cappuccino е идеално място за туристи, търсещи чар, комфорт и удобство в Рим.
Всички типове туристи (125) Двойка (57) Самостоятелно пътуващ (31) Семейство с малки деца (15) Семейство с големи деца (5) Група (17)
This apartment is located in a mixed use building (as in the apartments are located on one floor, the other floor are occupies by other businesses &/or residents), <5 min walk from Bologna Metro. A supermarket is located in the next building. The elevator is the old fashioned type where you have to to manually open / close 2 sets of doors to operate. And you do have to remember to close the doors after exiting otherwise people on other floors cannot use the elevator! Still an elevator is better than no elevator. You are given 4 keys to unlock a gate, the building door, the common door to 4 apartments managed by the same proprietor, & finally your own apartment door. These set of keys you have to carry around with you otherwise you cannot get in after office hours. The rooms (there are only 4) are generally small & dingy. The bed (for the single room) is a narrow single bed, not twin or double. There is a fridge, air-conditioning, & a small dining table with a grimy plastic sheet on which you take your breakfast every morning. The water, even boiled, from the taps at this place tastes rather metallic - don't know whether it is plumbing related. Note that one of the rooms has an exterior (non-attached) bathroom - this is clearly stated on the booking page so beware if you are particular. I think the prices for the rooms with attached bathroom & non-attached bathroom are roughly similar. The walls of the apartment are paper thin, so you can hear your neighbours opening & shutting the door, etc. The single room I stayed in was next to the exterior bathroom, so it was particularly annoying when the guests next door used their bathroom. Breakfast was standard fare - croissant, juice/ coffee. Not very filling, but that seems to be standard for B&Bs in Rome. The proprietor is friendly & would do her best to cater to your needs, but she speaks little English, so you might have difficulty communicating. For the price I paid, I would choose the B&B Il Viandante Romano

value: This website is a Singaporean online travel agency and metasearch engine for hotels, vacation rentals, flights, and airport transfer. It is owned by Agoda Company Pte.


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Dell Optiplex 990 790 Tower Desktop CPU Cooling Heatsink+ Fan,DP/N 0D0W1H D0W014 | eBay
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Details about Dell Optiplex 990 790 Tower Desktop CPU Cooling Heatsink+ Fan,DP/N 0D0W1H D0W014
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Last updated on 02 Sep, 2019 18:45:57 BST View all revisions
by graysolus_0 17 Apr, 2017
Fast, quiet, and just as advertised. If I ever need components like this again, I know who to go to!
by tomcat_65023 24 Nov, 2017
OEM CPU fan/Heatsink
by electrician230 27 Aug, 2019
it works well and removed another unit from trash.
Verified purchase: Yes | Condition: pre-owned | Sold by: lombeephre
by jeffchan-8 06 Aug, 2018
Won’t return closed return
Just asked for a return but they closed the return on me. Whatever.
Dell 12V CPU CPU Fan with Heatsinks,
Dell 3-Pin CPU CPU Fan with Heatsinks


text:
Sorry to hear the news about Jim. As a neighborhood kid growing up with your family, I always remember that if I was standing to close to the car on the driveway, Jim would stick a rag in my hand and tell me (and anyone else standing around) to wipe down the car. To this day, I sitll think of him when I wash my car! He may have been gruff on the outside, but deep down he was a softie. May his memory be a blessing to all.
He called me "the farmer" when we showed up to golf. When we left he would tell us I'll see you tomorrow. I shall miss his joking with us. Our prayers are with him and his family.
Jack & Becky Bowles,
To the Family and Special Friends of "Big Daddy" Jim Africa. My heart is with each and eveyone of you. I enjoyed doing my business with Big Daddy and his Partners at the Jiffy Mart.
Jim was family,my kids loved him as we all did.We played golf many times and there was no better friend than "BIG DADDY"
I am very sorry for your loss.I always looked forward to seeing Jim when I went to play golf.He always had a big smile and welcome glad to see you here. I will miss him and remember him everytime I pick up my clubs. May God's love and peace sustain you at this time of grief.
John Birka-White,

value: This website is a United States-based website founded in 1998, the world's largest commercial provider of online memorials. The Web site hosts obituaries and memorials for more than 70 percent of all U.S. deaths.


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Confrimed $7.000.00 For Life | eBay Please enable JavaScript Our new search experience requires JavaScript to be enabled. Please enable JavaScript on your browser, then try again.
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Confrimed $7.000.00 For Life: This is the median price based on sales of this product in the same condition from all listings on ebay.com in the past 14 days, or if there are any insufficient number of listings for a meaningful calculation, the past 90 days.


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Practice & Pass 11+. Level 1 Discover Maths by Peter Williams 9781844552580 | eBay
Practise Pass 11 Level 1 Discover Verbal Reasoning
Maths Level 6: Learn and Practise (Letts Key Stage 3 Success) (Letts Key Stage 3
Practise & Pass 11+ Level Two: Develop Maths (Practise & Pass 11+).
Details about Practice & Pass 11+. Level 1 Discover Maths by Peter Williams
Practice & Pass 11+. Level 1 Discover Maths by Peter Williams
333357571211
Author: Peter Williams Language: English
Publication Year: 2010 Title: Practice & Pass 11+. Level 1 Discover Maths
ISBN: 9781844552580 EAN: 9781844552580
eBay Product ID (ePID) 107624710


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Dai-Ming Fan64
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MicroRNAs are small non-coding RNA molecules that control expression of target genes. Previous studies showed that microRNA-107 (miR-107) is overexpressed in gastric cancer tissues compared with the… (More)

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Changes Salon - Conyers, GA | Groupon
All Deals 9428 Automotive 223 Beauty & Spas 2832 Food & Drink 530 Health & Fitness 1503 Home Services 570
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text:
9781402505393: Founding Brothers: The Revolutionary Generation - Joseph J Ellis
13892911810
13968061320
13524956387
Good. Discs have light scratches/scuffs. Case has wear on edges/corners.
13938825188
13751226905
13852908215
13919057859
13458265469
Good. 1402505396 Thousands of satisfied customers, 100% money back guarantee! Used books may contain some notes or highlighting, also MAY NOT contain CDs, DVDs or access codes.
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text:
Words that start with finmar | Words starting with finmar
Words that start with finmar | Words starting with finmar http://www.thefreedictionary.com/words-that-start-with-finmarPrinter Friendly
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Words that start with finmar
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value: This website is an American online dictionary and encyclopedia that aggregates information from various sources.