Zubsolv will be given to you in one to four doses over the course of the day. If your doctor prescribes more than one dose on day 1, you'll likely take Zubsolv every 1.5 to 2 hours. On day 2, your doctor will prescribe one dose of Zubsolv. The maximum dose on this day is 11.4 mg buprenorphine/2.9 mg naloxone.