history of Rome , Georgia extends to thousands of years of human settlement by ancient Native Americans . Spanish explorers recorded reaching the area in the later 16th century , and European Americans of the United States founded the city named Rome in 1834 , when the residents of the area were still primarily Cherokee , before their removal on the Trail of Tears to Indian Territory . The competition for resources among its diverse inhabitants led to both innovation and strife . Its location at the confluence of three rivers enabled Rome to develop as a crossroads for trade and transportation . The city was later designated as the county seat of Floyd County , Georgia . Today , Rome is the largest city in Northwest Georgia , and is a regional center of healthcare , education , and manufacturing
Trail of Tears
Trail of Tears
History of Rome, Georgia