Sean Burns wrote in the '' Philadelphia Weekly '' that Levine " knows how to stay out of the way long enough to let a very talented cast shine , and Rogen 's fundamental , unexpected decency , which can often only be expressed through shoulder-punching obscenities , grows more quietly moving as the picture wears on . " David Schmader , writing in the '' Stranger '' , praises " ' 50/50 's stellar cast , from the omnipresent lead Joseph Gordon-Levitt ( whose Rankin/Bass puppet face is put to beautifully nuanced use ) to the all-star supporting cast : Anjelica Huston roars back to prominence with a twisty performance as Adam 's barely contained mess of a mom , and Anna Kendrick 's young doctoral student makes the film 's rom-com aspirations not-ridiculous with her intelligent spontaneity and cute smile . But the comedy star is Seth Rogen , cast in the same role he played in screenwriter Reiser 's life . " The film was nominated for two awards at the 69th Golden Globe Awards . Gordon-Levitt received a nomination for Best Actor ( Musical or Comedy ) and the film itself was nominated for Best Picture ( Musical or Comedy )
69th Golden Globe Awards
69th Golden Globe Awards
50/50 (2011 film)