Among the cities in the region , Varaždin and Zagreb occupy particularly prominent places in terms of culture . Varaždin is often considered the most significant centre of baroque culture and heritage in Croatia . That claim is reflected in the city 's historical architecture and cultural events , based on traditions of the city from the era . Zagreb , on the other hand , is the largest cultural centre , not only in the region , but also in Croatia as a whole . It is home to dozens of galleries , museums , and theatres as well as being the site of numerous landmarks . The landmarks include the Zagreb Cathedral , founded in 1093 and rebuilt numerous times since , the last major reconstruction being after the 1880 earthquake . The cathedral is the tallest structure in Croatia . Zagreb is the most significant centre of scientific work and education in the region and the entire country . It is the site of the University of Zagreb — the oldest place of higher education in Croatia and Southeast Europe , operating continuously since 1669 . It is also home to the Ruđer Bošković Institute — the leading Croatia 's scientific research institute — and to the Croatian Academy of Sciences and Arts
1880 earthquake
1880 Zagreb earthquake
Croatia proper