In 1622 , battles continued between neighboring tribes and English Settlers . This eventually became known as the Indian Massacre of 1622 . Three years later in 1625 , a smallpox and measles outbreak killed many Native Indians who did not have natural immunity to such illnesses . In 1650 , European presence increased as more and more settlers arrived in North Carolina . With such large numbers of men arriving , the male to female ratio in the Albemarle region of North Carolina was close to 8 to 1 . In 1670 , marriages between British settlers and Indian women started to occur . This encouraged the exchange of cultures and prompted negotiations to end the constant battles. : During negotiations the battles continued and as a result the tribe 's population dramatically decrease . By 1700 , it is believed that the Weapemeoc tribe only had a population of around 200 people
Indian Massacre of 1622
Indian massacre of 1622
Weapemeoc Indians