The accompanying music video for " Me Against the Music " shows Spears and Madonna playing opposites in a nightclub . A cat-and-mouse chase ensues , and Spears finds Madonna in the end , only for the latter to disappear before they kiss . The video received positive reviews from critics , who noted it as symbolic of the sexual roles between the women . Spears has performed the song in a number of live appearances including the 2003 NFL Kickoff Live , '' Saturday Night Live '' , 2003 American Music Awards and '' TRL '' . She has also performed remixed versions with elements of bhangra music at The Onyx Hotel Tour ( 2004 ) and The Circus Starring Britney Spears ( 2009 ) . Spears performed the song on her Las Vegas residency show Britney : Piece of Me . " Me Against the Music " has been sampled by Justice , while the music video was recreated by television series '' Glee '' and included an appearance by Spears
2003 American Music Awards
American Music Awards of 2003 (November)
Me Against the Music