Other major north – south routes in Fayetteville include US 71B , which was the predecessor to I-49 / US 71 . This route is now mostly designated College Avenue in Fayetteville and features dozens of restaurants and stores , with many aimed at the University of Arkansas student demographic . To the east of College Avenue is the oldest road in Fayetteville , Arkansas Highway 265 . This route first was used by Native Americans as the Great Osage Trail , followed by Civil War troops bound for Fort Smith , Arkansas , the Trail of Tears , the Butterfield Overland Mail stagecoach route , and later still the telegraph . To the west of College Avenue is Gregg Avenue , which contains many student-oriented apartments along its shoulders and further west is Garland Avenue . This route runs along the campus of the University of Arkansas in south Fayetteville , with apartments and duplexes along its northern routing
Trail of Tears
Trail of Tears
Fayetteville, Arkansas