Run ( I 'm a Natural Disaster ) " , also known more commonly as " Run " , is a song written and recorded by Gnarls Barkley . It is the first single to be released from the band 's second album '' The Odd Couple '' . Released in February 2008 as a digital download in the UK and the US via the iTunes Store , a physical release of the single followed in the UK on March 31 . The song features a sample from Keith Mansfield 's " Junior Jet Set " from the KPM LP '' Flamboyant Themes '' and " Starting Out the Day " by Strawberry Alarm Clock . The song is featured in the film '' X-Men : First Class '' , as a playable song in the video game '' Dance Central 2 '' , and is heard in promos for Disney-Pixar 's '' Cars 2 '' . This song was number 34 on '' Rolling Stone '' s list of the 100 Best Songs of 2008 . The video premiered on MTV Overdrive on February 29 , 2008 . The video features Cee-Lo and Danger Mouse performing on a TV show called " City Vibin ' " , reminiscent of '' Graffiti Rock '' . Cee-Lo Green sings the song behind a microphone stand , while Danger Mouse plays the song 's music on a turntable . Justin Timberlake appears in a cameo as the host of the show . The video features dizzying special effects such as hypnotic spirals , and as a result was banned from airplay in the United States after failing the Harding test ( a test designed to protect sufferers of photosensitive epilepsy ) . The hypnotic spirals were later toned down upon request and the video premiered on '' TRL '' March 6 , 2008 . The video won for Best Choreography as well as Best Art Direction in a Video at the 2008 MTV Video Music Awards
2008 MTV Video Music Awards
2008 MTV Video Music Awards
Run (I'm a Natural Disaster)