After Wahunsenacawh 's death , his younger brother , Opitchapam , briefly became chief , followed by their younger brother Opechancanough . In 1622 ( Indian massacre of 1622 ) and 1644 he attacked the English to force them from Powhatan territories . Both these attempts were met with strong reprisals from the English , ultimately resulting in the near destruction of the tribe . The Second Anglo – Powhatan War that followed the 1644 incident ended in 1646 , after Royal Governor of Virginia William Berkeley 's forces captured Opechancanough , thought to be between 90 and 100 years old . While a prisoner , Opechancanough was killed , shot in the back by a soldier assigned to guard him . He was succeeded as '' Weroance '' by Necotowance , and later by Totopotomoi and by his daughter Cockacoeske
Indian massacre of 1622
Indian massacre of 1622
Powhatan