265 : On November 12 , 2001 , American Airlines Flight 587 , an Airbus A300 , crashed in the Belle Harbor neighborhood of Queens , New York , just after departing John F. Kennedy International Airport bound for Las Américas International Airport , Santo Domingo . The first officer 's overuse of the rudder in response to wake turbulence from a Japan Airlines 747 was cited as cause . All 260 people on board , as well as five people on the ground , died from the crash . It is the second-deadliest aviation accident on U.S. soil , after American Airlines Flight 191
American Airlines Flight 191
American Airlines Flight 191
Aviation accidents and incidents