Construction of I-380 took 12 years to complete , ending in 1985 . After the interstate opened , US 218 was moved onto the new freeway . In the 1990s , the I-380 corridor was selected as part of the Avenue of the Saints corridor , which Iowa designated as Iowa 27 in 2001 . I-380 has been affected by two major floods , the Great Flood of 1993 and the Iowa flood of 2008 , both of which closed the road at the Iowa River for two weeks
Great Flood of 1993
Great Flood of 1993
Interstate 380 (Iowa)