The song also appears on the soundtrack of the 2001 film '' Moulin Rouge ! '' and is sung by the characters Harold Zidler , played by Jim Broadbent , and The Duke of Monroth , played by Richard Roxburgh . In 2004 , The Meat Purveyors covered the song in a bluegrass medley , pairing it with Madonna 's " Lucky Star " and " Burning Up . " In the 2004 film '' Bridget Jones : The Edge of Reason '' , the title character teaches the song to women in a Thai prison , after becoming annoyed that they are singing the song badly . She tells them , " Madonna is nothing if not a perfectionist ! " In one of the episodes of the TV show '' Grey 's Anatomy '' , the character of Cristina Yang hums the song during surgery to take the focus off herself . However , when her assisting surgery , Lexie Grey starts singing along , Christina looks venomously at her until she quiets down . Katy Perry , Travis Barker and DJ AM covered the song at the 2008 MTV Video Music Awards . In 2009 , the song was namechecked in the Train hit single " Hey , Soul Sister " with the lyric " I believe in you/Like a virgin you 're Madonna/And I 'm always gon na wan na blow your mind "
2008 MTV Video Music Awards
2008 MTV Video Music Awards
Like a Virgin (song)