Shortly after it departed from Asheville Regional Airport in Asheville , North Carolina , on July 19 , 1967 , Piedmont Airlines Flight 22 collided with a twin-engine Cessna 310 on approach to Asheville . At the time of the accident , the Piedmont Boeing 727 was en route to Roanoke . There were 82 fatalities and no survivors , making this the deadliest accident associated with Roanoke Regional Airport
Piedmont Airlines Flight 22
Piedmont Airlines Flight 22
Roanoke–Blacksburg Regional Airport