Near the end of her husband 's presidency , Clinton became the first first lady to run for political office . During the campaign , her daughter , Chelsea , took over much of the first lady 's role . Victorious , Clinton served as U.S. Senator from New York from 2001 to 2009 , when she resigned in order to become President Obama 's Secretary of State until 2013 . Clinton was the Democratic Party nominee for president in the 2016 election , but lost to Donald Trump
Democratic Party
2016 Democratic National Convention
First Lady of the United States