He was parodied in the '' South Park '' episode " Smug Alert ! " , which mocks his acceptance speech at the 78th Academy Awards . Clooney has also lent his voice to '' South Park '' as Sparky the Dog in " Big Gay Al 's Big Gay Boat Ride " and as the emergency room doctor in '' South Park : Bigger , Longer & Uncut '' . Clooney was caricatured in the '' American Dad ! '' episode " Tears of a Clooney " , in which Francine Smith plans to destroy him
78th Academy Awards
78th Academy Awards
George Clooney