Armenian Mesopotamia was a region in Northern Mesopotamia that was inhabited partly by Armenians , Tigranes the Great seized Northern Mesopotamia , and from 401 BC , to 387 AD was part of Kingdom of Armenia . Later it became part of Sassanid Empire , Arab Caliphate , Buyids , County of Edessa , Timurids , Kara Koyunlu , Ak Koyunlu , and the Safavids . Then , following the 1639 Treaty of Zuhab , it became part of the Ottoman Empire ( although briefly taken by Nader Shah of the Iranian Afsharid dynasty ) and Turkey . Armenian population remained until 1915 's Armenian Genocide
Armenian Genocide
Armenian Genocide
Armenian Mesopotamia