Is it possible for remote workers to replace IT jobs currently performed by H1-B visa holders, wherever applicable, while giving priority to local workers? 

Recent trends show about 20% of U.S. workers work remotely at least part-time, including those on H-1B visas. However, H-1B visa regulations require that the work location aligns with the Labor Condition Application (LCA), and remote work might necessitate amendments if outside the commuting distance of the listed worksite. Thus, while many IT roles might be suitable for remote work, stating that the majority are without considering these legal nuances might not be entirely accurate.