Since the 1989 NFL season, when the Bills are playing as a Home Favorite of (-8.5) or greater against a non-division opponent, their record is:

SU: 27-1 (96.4%)
ATS: 19-9 (67.9%)
O/U: 19-9 (67.9%)

Bills (-8.5) are in this spot against the Broncos in the Wild Card round of the NFL Playoffs